A/Prof. Derek Laver

Work Phone	(02) 4921 8732
Fax	(02) 4921 7406
Email	Derek.Laver@newcastle.edu.au
Office	MS407, Medical Sciences

Highlighted Publications

Year	Citation	Link
2005	Beard N A, Casarotto M G, Wei L, Varsanyi Magdolna, Laver Derek Rowland, Dulhunty A F, 'Regulation of ryanodine receptors by calsequestrin: Effect of high luminal Ca2+ and phosphorylation', Biophysical Journal, 88 3444-3454 (2005) [C1]
2003	Haarmann C, Green D, Casarotto M G, Laver Derek Rowland, Dalhunty A F, 'The Random-Coil 'C' fragment of the dihydropyridine receptor II-III loop can activate or inhibit native skeletal ryanodine receptors', Biochemical journal, 375 305-316 (2003) [C1]
2004	Laver Derek Rowland, O'Neill Erin Rowena, Lamb Graham D, 'Luminal Ca2+ - regulated Mg2+ inhibition of skeletal RyRs reconstituted as isolated channels or coupled clusters', J Gen Physiol, 124 741-758 (2004) [C1]
2008	Laver Derek Rowland, Honen Bonny Nicole, 'Luminal Mg2+, a key factor controlling RYR2-mediated Ca2+ release: Cytoplasmic and luminal regulation modeled in a tetrameric channel', Journal of General Physiology, 132 429-446 (2008) [C1]
2007	Laver Derek Rowland, 'Ca2+ stores regulate ryanodine receptor Ca2+ release channels via luminal and cytosolic Ca2+ sites', Biophysical Journal, 92 3541-3555 (2007) [C1]
2007	Laver Derek Rowland, Hamada Tomoyo, Fessenden James D, Ikemoto Noriaki, 'The ryanodine receptor pore blocker neomycin also inhibits channel activity via a previously undescribed high-affinity Ca2+ binding site', Journal of Membrane Biology, 220 11-20 (2007) [C1]
2006	Laver Derek Rowland, Bradley Katherine Michelle, 'Disulfonic stilbene permeation and block of the anion channel from the sarcoplasmic reticulum of rabbit skeletal muscle', American Journal of Physiology-Cell Physiology, 290 C1666-C1677 (2006) [C1]
2005	Haarmann Claudia S, Dulhunty A F, Laver Derek Rowland, 'Regulation of skeletal ryanodine receptors by dihydropyridine receptor II-III loop C-region peptides: relief of Mg2+ inhibition', Biochemical Journal, 387 429-436 (2005) [C1]
2005	Lindquist C E L, Laver Derek Rowland, Birnir B, 'The mechanism of SR95531 inhibition at GABA(A) receptors examined in human alpha(1)beta(1) and alpha(1)beta(1)gamma(2S) receptors', Journal of Neurochemistry, 94 491-501 (2005) [C1]
2009	Watanabe Hiroshi, Chopra Nagesh, Laver Derek Rowland, Hwang Hyun Seok, Davies Sean S, Roach Daniel E, Duff Henry J, Roden Dan M, Wilde Arthur A M, Knollmann Bjorn C, 'Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans', Nature Medicine, 15 380-383 (2009) [C1]

Publications

For items published while at an institution other that the University of Newcastle, details are shown in italics.

Click on a category title below to expand the list of citations for that specific category.

Chapters In A Book (2 outputs)

Chapter in A1 Book (B1) (2 outputs)

Year	Citation	Link
2010	Laver Derek Rowland, 'Regulation of RyR Channel Gating by Ca2+, Mg2+ and ATP', Structure and Function of Calcium Release Channels, Academic Press, Waltham, 69-89 (2010) [B1]
2009	Laver Derek Rowland, 'Electrical methods for determining surface charge density and electrolyte composition at the lipid bilayer-solution interface', Advances in Planar Lipid Bilayers and Liposomes, Elsevier, Amsterdam, 87-105 (2009) [B1]

Journal Articles (33 outputs)

Refereed Article in a Scholarly Journal (C1) (32 outputs)

Year	Citation	Link
2012	Seymour Victoria A L, Curmi John P, Howitt Susan M, Casarotto Marco G, Laver Derek Rowland, Tierney M Louise, 'Selective modulation of different GABA A receptor isoforms by diazepam and etomidate in hippocampal neurons', International Journal of Biochemistry and Cell Biology, 44 1491-1500 (2012) [C1]
2011	Hwang Hyun Seok, Hasdemir Can, Laver Derek Rowland, Mehra Divya Rajendra, Turhan Kutsal, Faggioni Michela, Yin Huiyong, Knollmann Bjorn C, 'Inhibition of Cardiac Ca2+ Release Channels (RyR2) Determines Efficacy of Class I Antiarrhythmic Drugs in Catecholaminergic Polymorphic Ventricular Tachycardia', Circulation: Arrhythmia and Electrophysiology, 4 128-135 (2011) [C1]
2011	Laver Derek Rowland, Van Helden Dirk Ferdinand, 'Three independent mechanisms contribute to tetracaine inhibition of cardiac calcium release channels', Journal of Molecular and Cellular Cardiology, 51 357-369 (2011) [C1]
2010	Hilliard Fredrick A, Steele Derek S, Laver Derek Rowland, Yang Zhaokang, Le Marchand Sylvain J, Chopra Nagesh, Piston David W, Huke Sabine, Knollmann Bjorn C, 'Flecainide inhibits arrhythmogenic Ca2+ waves by open state block of ryanodine receptor Ca2+ release channels and reduction of Ca2+ spark mass', Journal of Molecular and Cellular Cardiology, 48 293-301 (2010) [C1]
2010	Imtiaz Mohammad S, Von Der Weid Pierre-Yves, Laver Derek Rowland, Van Helden Dirk Ferdinand, 'SR Ca2+ store refill-a key factor in cardiac pacemaking', Journal of Molecular and Cellular Cardiology, 49 412-426 (2010) [C1]
2010	Shtifman Alexander, Ward Christopher W, Laver Derek Rowland, Bannister Mark L, Lopez Jose R, Kitazawa Masashi, Laferla Frank M, Ikemoto Noriaki, Querfurth Henry W, 'Amyloid-β protein impairs Ca²⁺ release and contractility in skeletal muscle', Neurobiology of Aging, 31 2080-2090 (2010) [C1]
2010	Van Helden Dirk Ferdinand, Laver Derek Rowland, Holdsworth John Lionel, Imtiaz Mohammad S, 'Generation and propagation of gastric slow waves', Clinical and Experimental Pharmacology and Physiology, 37 516-524 (2010) [C1]
2009	Chopra Nagesh, Laver Derek Rowland, Davies Sean S, Knollmann Bjorn C, 'Amitriptyline activates cardiac ryanodine channels and causes spontaneous sarcoplasmic reticulum calcium release', Molecular Pharmacology, 75 183-195 (2009) [C1]
2009	Everitt Andrea B, Seymour Victoria A L, Curmi John, Laver Derek Rowland, Gage Peter W, Tierney M Louise, 'Protein interactions involving the gamma 2 large cytoplasmic loop of GABA(A) receptors modulate conductance', FASEB Journal, 23 4361-4369 (2009) [C1]
2009	Laver Derek Rowland, 'Luminal Ca2+ activation of cardiac ryanodine receptors by luminal and cytoplasmic domains', European Biophysics Journal, 39 19-26 (2009) [C1]
2009	Watanabe Hiroshi, Chopra Nagesh, Laver Derek Rowland, Hwang Hyun Seok, Davies Sean S, Roach Daniel E, Duff Henry J, Roden Dan M, Wilde Arthur A M, Knollmann Bjorn C, 'Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans', Nature Medicine, 15 380-383 (2009) [C1]
2008	Laver Derek Rowland, Honen Bonny Nicole, 'Luminal Mg2+, a key factor controlling RYR2-mediated Ca2+ release: Cytoplasmic and luminal regulation modeled in a tetrameric channel', Journal of General Physiology, 132 429-446 (2008) [C1]
2008	Laver Derek Rowland, Honen Bonny Nicole, Lamb Graham D, Ikemoto Noriaki, 'A domain peptide of the cardiac ryanodine receptor regulates channel sensitivity to luminal Ca2+ via cytoplasmic Ca2+ sites', European Biophysics Journal with Biophysics Letters, 37 455-467 (2008) [C1]
2007	Laver Derek Rowland, 'Ca2+ stores regulate ryanodine receptor Ca2+ release channels via luminal and cytosolic Ca2+ sites', Biophysical Journal, 92 3541-3555 (2007) [C1]
2007	Laver Derek Rowland, 'Ca2+ stores regulate ryanodine receptor Ca2+ release channels via luminal and cytosolic Ca2+ sites', Clinical and Experimental Pharmacology and Physiology, 34 889-896 (2007) [C1]
2007	Laver Derek Rowland, Hamada Tomoyo, Fessenden James D, Ikemoto Noriaki, 'The ryanodine receptor pore blocker neomycin also inhibits channel activity via a previously undescribed high-affinity Ca2+ binding site', Journal of Membrane Biology, 220 11-20 (2007) [C1]
2006	Laver Derek Rowland, 'Regulation of ryanodine receptors from skeletal and cardiac muscle during rest and excitation', Clinical and Experimental Pharmacology & Physiology, 33 1107-1113 (2006) [C1]
2006	Laver Derek Rowland, Bradley Katherine Michelle, 'Disulfonic stilbene permeation and block of the anion channel from the sarcoplasmic reticulum of rabbit skeletal muscle', American Journal of Physiology-Cell Physiology, 290 C1666-C1677 (2006) [C1]
2005	Beard N A, Casarotto M G, Wei L, Varsanyi Magdolna, Laver Derek Rowland, Dulhunty A F, 'Regulation of ryanodine receptors by calsequestrin: Effect of high luminal Ca2+ and phosphorylation', Biophysical Journal, 88 3444-3454 (2005) [C1]
2005	Haarmann Claudia S, Dulhunty A F, Laver Derek Rowland, 'Regulation of skeletal ryanodine receptors by dihydropyridine receptor II-III loop C-region peptides: relief of Mg2+ inhibition', Biochemical Journal, 387 429-436 (2005) [C1]
2005	Laver Derek Rowland, 'Coupled calcium release channels and their regulation by luminal and cytosolic ions', European Biophysics Journal with Biophysics Letters, 34 359-368 (2005) [C1]
2005	Lindquist C E L, Laver Derek Rowland, Birnir B, 'The mechanism of SR95531 inhibition at GABA(A) receptors examined in human alpha(1)beta(1) and alpha(1)beta(1)gamma(2S) receptors', Journal of Neurochemistry, 94 491-501 (2005) [C1]
2004	Beard N A, Laver Derek Rowland, Dulhunty A F, 'Calsequestrin and the calcium release challen of skeletal and cardiac muscle', Progress in Biophysics & Molecular Biology, 85 33-69 (2004) [C1]
2004	Laver Derek Rowland, O'Neill Erin Rowena, Lamb Graham D, 'Luminal Ca2+ - regulated Mg2+ inhibition of skeletal RyRs reconstituted as isolated channels or coupled clusters', J Gen Physiol, 124 741-758 (2004) [C1]
2003	Haarmann C S, Green D, Casarotto M G, Laver D R, Dulhunty A F, 'The random-coil ‘C’ fragment of the dihydropyridine receptor II–III loop can activate or inhibit native skeletal ryanodine receptors', Biochemical Journal, 372 305-316 (2003) [C1]
2003	Haarmann C, Green D, Casarotto M G, Laver Derek Rowland, Dalhunty A F, 'The Random-Coil 'C' fragment of the dihydropyridine receptor II-III loop can activate or inhibit native skeletal ryanodine receptors', Biochemical journal, 375 305-316 (2003) [C1]
2003	Honen B N, Saint D A, Laver Derek Rowland, 'Supression of Calcium Sparks in Rat Ventricular Myocytes and Direct Inhitition of Sheep Cardiac RyR Channels by EPA, DHA and Oleic Acid', Journal of Membrane Biology, 196 95-103 (2003) [C1]
2003	O'Neill Erin Rowena, Sakowska Magdalena M, Laver Derek Rowland, 'Regulation of the Calcium Release Channel from Skeletal Muscle by Suramin and the Disulfonated Stilbene Derivatives DIDS, DBDS, and DNDS', Biophysical Journal, 84 1674-1689 (2003) [C1]
2002	Beard N A, Sakowska M M, Dulhunty A F, Laver D R, 'Calsequestrin is an Inhibitor of Skeletal Muscle Ryanodine Receptor Calcium Release Channels', Biophysical Journal, 82 310-320 (2002) [C1]
1997	Laver D R, Baynes T M, Dulhunty A F, 'Mg2+-Inhibition of Ryanodine-sensitive Ca2+ Channels: Evidence for Two Independent Mechanisms', Journal of Membrane Biology, 156 213-229 (1997) [C1]
1997	Laver D R, Owen V J, Junankar P R, Taske N L, Dulhunty A F, Lamb G D, 'Ca2+- and Mg2+-Regulation of Calcium Release Channels from Normal and Malignant Hyperthermia Susceptible Pigs', Biophysical Journal, 73 1913-1924 (1997) [C1]
1995	Laver D R, Roden L D, Ahem G P, Eager K R, Junankar P R, Dulhunty A F, 'Cytoplasmic Ca2+ Inhibits the Ryanodine Receptor from Cardiac Muscle', Journal of Membrane Biology, 147 7-22 (1995) [C1]
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Non Refereed Article in a Professional Journal (C3) (1 outputs)

Year	Citation	Link
2006	Lindquist C E L, Laver Derek Rowland, Birnir B, 'The mechanism of SR95531 inhibition at GABA(A) receptors examined in human alpha(1)beta(1) and alpha(1)beta(1)gamma(2S) receptors (vol 94, pg 491, 2005) (Errartum)', Journal of Neurochemistry, 97 302-302 (2006) [C3]

Conference Publication (18 outputs)

Extract of Paper (E3) (18 outputs)

Year	Citation	Link
2012	Li Jiao, Imtiaz Mohammad Sahariq, Beard N A, Dulhunty A F, Thorne Rick Francis, Van Helden Dirk Ferdinand, Laver Derek Rowland, 'Adrenergic stimulation alters RyR2 regulation by Ca2+ and Mg2+', Heart, Lung and Circulation: Abstracts of ISHR Auckland Workshop, Auckland, NZ (2012) [E3]
2011	Mehra Divya Rajendra, Van Helden Dirk Ferdinand, Hwang H S, Knollmann B, Laver Derek Rowland, 'Role of cardiac Na+ channel blockers in inhibiting the cardiac calcium release channel', Proceedings of the Australian Physiological Society 2011, Perth (2011) [E3]
2011	Morris D, Saint D, Laver Derek Rowland, 'Negative inotropic effect of riluzole: Blockade of the ryanadine receptor?', Heart, Lung and Circulation, Perth, WA (2011) [E3]
2011	Walweel K, Li Jingjing, Van Helden Dirk Ferdinand, Imtiaz Mohammad Sahariq, Molenaar P, Laver Derek Rowland, 'Regulation of RyRs by intracellular Ca2+ and Mg2+ compared in sheep, rat and human heart', Proceedings of the Australian Physiological Society 2011, Perth (2011) [E3]
2009	Hilliard Frederick A, Laver Derek Rowland, Le Marchand Sylvain J, Piston David W, Knollmann Bjorn G, 'Flecainide inhibits arrhythmogenic Ca2+ waves by open state block of ryanodine receptor Ca2+ release channels and reduction of Ca2+ spark mass', Circulation, Orlando, FL (2009) [E3]
2009	Hollins Sharon Lee, Johnstone Daniel McKenzie, Graham Ross, Van Helden Dirk Ferdinand, Kerr Karen Patricia, Laver Derek Rowland, Metelerkamp Kirsty Meredith, Trinder Deborah, Fleming Robert, Scott Rodney, Olynyk John, Milward Adrienne Elizabeth, 'Cardiac gene expression in mouse models of iron loading disorders', 2009 International Biolron Society Meeting: Program Book, Porto, Portugal (2009) [E3]
2009	Hollins Sharon Lee, Johnstone Daniel McKenzie, Van Helden Dirk Ferdinand, Kerr Karen Patricia, Laver Derek Rowland, Metelerkamp Kirsty Meredith, Scott Rodney, Milward Adrienne Elizabeth, 'Cardiac gene expression in mouse models of iron loading', ASMR XVII NSW Scientific Meeting: Programme and Abstracts, Sydney, NSW (2009) [E3]
2009	Laver Derek Rowland, Quail Anthony Walker, Sitsapesan Holly, Van Helden Dirk Ferdinand, 'The effect of volatile anaesthetics on the cardiac ryanodine receptor', Biophysical Journal, Boston, MA (2009) [E3]
2009	Mehra Divya Rajendra, Van Helden Dirk Ferdinand, Knollmann Bjorn, Laver Derek Rowland, 'Flecainide inhibits CPVT induced cardiac arrhythmias by open state block of ryanodine receptor Ca2+ release channels and reduction of Ca2+ spark mass', 33rd Annual Meeting of the Australian Society for Biophysics: Program, Ballarat, VIC (2009) [E3]
2008	Chopra Nagesh, Watanabe Hiroshi, Laver Derek Rowland, Hwang Hyun S, Roden Dan M, Knollmann Bjorn C, 'Flecainide blocks cardiac ryanodine channels and prevents catecholaminergic ventricular tachycardia in cardiac calsequestrin null mice', Circulation, - (2008) [E3]
2008	Laver Derek Rowland, Quail Anthony Walker, Sitsapesan H, Van Helden Dirk Ferdinand, 'Effect of volatile anaesthetics on the calcium release channel in the heart', Proceedings of the Australian Physiological Society, Melbourne, VIC (2008) [E3]
2008	Van Helden Dirk Ferdinand, Laver Derek Rowland, Imtiaz Mohammad Sahariq, 'Ca2+ phase waves: A fundamental mechanism underlying propagation of gastric slow waves', Proceedings of the Australian Physiological Society, Melbourne, VIC (2008) [E3]
2007	Chopra Nagesh, Laver Derek Rowland, Watanabe Hiroshi, Nair Usha B, Stein C M, Knollmann Bjorn C, 'Amitriptyline activates cardiac ryanodine receptors independently of its action on cardiac calsequestrin: Role for amitriptyline linked sudden cardiac death', Circulation, Orlando, FL. (2007) [E3]
2007	Tierney M L, Everitt A B, Seymour V A L, Laver Derek Rowland, 'Subunit-specific interactions between gabaa receptors underlie diazepam modulated high conductance gaba channels (Poster)', 7th IBRO 2007 World Congress of Neuroscience Program, Melbourne (2007) [E3]
2005	Honen Bonny Nicole, Dalton Rebecca Louise, Van Helden Dirk Ferdinand, Laver Derek Rowland, 'Acute application of n-3 polyunsaturated fatty acids modify calcium sparks in permeabilised rat cardiac myocytes', Proceedings of the Australian Physiological Society, Canberra (2005) [E3]
2005	Laver Derek Rowland, 'Regulation of ryanodine receptors from skeletal and cardiac muscle by components of the cytoplasm and lumen', Proceedings of the Australian Physiological Society, Canberra (2005) [E3]
2004	Haarmann Claudia S, Dulhunty Angela F, Laver Derek Rowland, 'The manifold effects of peptide C region of the DHPR II-III loop on RyRs', Biophysical Journal, Maryland, USA (2004) [E3]
2004	Honen Bonny Nicole, Saint David A, Van Helden Dirk Ferdinand, Laver Derek Rowland, 'The effects of fatty acids on SR calcium release channels from cardiac muscle', Biophysical Journal, Maryland, USA (2004) [E3]
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The University of Newcastle, Australia