A/Prof. Darren Shafren

Work Phone	(02) 4913 8158
Fax	(02) 4913 8814
Email	Darren.Shafren@newcastle.edu.au
Office	DMB305, David Maddison Clinical Sciences Building

Highlighted Publications

Year	Citation	Nova
2005	Au Gough Geoffrey, Lindberg A M, Barry Richard Desmond, Shafren Darren Raymond, 'Oncolysis of vascular malignant human melanoma tumors by Coxsackievirus A21', International Journal of Oncology, 26 1471-1476 (2005) [C1]
2005	Shafren Darren Raymond, Sylvester Dianne Elizabeth, Johansson Eva Susanne, Campbell I G, Barry Richard Desmond, 'Oncolysis of human ovarian cancers by echovirus type 1', International Journal of Cancer, 115 320-328 (2005) [C1]
2004	Johansson Eva Susanne, Xing L, Cheng Rh, Shafren Darren Raymond, 'Enhanced cellular receptor usage by a bioselected variant of Coxsackievirus A21', Journal of Virology, 78, No.22 12603-12612 (2004) [C1]
2004	Shafren Darren Raymond, Au Gough Geoffrey, Nguyen Tam, Barry Richard Desmond, Hansbro Nicole Gower, Harvey Erin Susannah, Beagley Leone, Johansson Eva Susanne, Hersey Peter, 'Systemic therapy of malignant human melanoma tumors by a common cold-producing enterovirus, Coxsackievirus A21', Clinical Cancer Research, 10 53-60 (2004) [C1]

Publications

For items published while at an institution other that the University of Newcastle, details are shown in italics.

Click on a category title below to expand the list of citations for that specific category.

Journal Articles (22 outputs)

Refereed Article in a Scholarly Journal (C1) (22 outputs)

Year	Citation	Nova
2012	Skelding Kathryn Anne, Barry Richard Desmond, Shafren Darren Raymond, 'Enhanced oncolysis mediated by Coxsackievirus A21 in combination with doxorubicin hydrochloride', Investigational New Drugs, 30 568-581 (2012) [C1]
2011	Au Gough Geoffrey, Beagley Leone G, Haley Erin Susannah, Barry Richard D, Shafren Darren Raymond, 'Oncolysis of malignant human melanoma tumors by Coxsackieviruses A13, A15 and A18', Virology Journal, 8 1-6 (2011) [C1]
2011	Wood Lisa Gai, Powell Heather, Grissell Terry Vincent, Davies Bronwyn Lee, Shafren Darren Raymond, Whitehead Bruce Foster, Hensley Michael John, Gibson Peter Gerard, 'Persistence of rhinovirus RNA and IP-10 gene expression after acute asthma', Respirology, 16 291-299 (2011) [C1]
2009	Haley Erin Susannah, Au Gough Geoffrey, Carlton Brian Richard, Barry Richard Desmond, Shafren Darren Raymond, 'Regional administration of oncolytic Echovirus 1 as a novel therapy for the peritoneal dissemination of gastric cancer', Journal of Molecular Medicine, 87 385-399 (2009) [C1]
2009	Skelding Kathryn Anne, Barry Richard Desmond, Shafren Darren Raymond, 'Systemic targeting of metastatic human breast tumor xenografts by Coxsackievirus A21', Breast Cancer Research and Treatment, 113 21-30 (2009) [C1]
2008	Howland Linda Jean, Au Gough Geoffrey, Barry Richard Desmond, Shafren Darren Raymond, 'Potent oncolytic activity of human enteroviruses against human prostate cancer', Prostate, 68 577-587 (2008) [C1]
2008	Powell Heather, Smart Joanne Margaret, Wood Lisa Gai, Grissell Terry Vincent, Shafren Darren Raymond, Hensley Michael John, Gibson Peter Gerard, 'Validity of the common cold questionnaire (CCQ) in asthma exacerbations', PLoS ONE, 3 e1802 (2008) [C1]
2007	Au Gough Geoffrey, Lincz Lisa, Enno Arno, Shafren Darren Raymond, 'Oncolytic Coxsackievirus A21 as a novel therapy for multiple myeloma', British Journal of Haematology, 137 133-141 (2007) [C1]
2005	Au Gough Geoffrey, Lindberg A M, Barry Richard Desmond, Shafren Darren Raymond, 'Oncolysis of vascular malignant human melanoma tumors by Coxsackievirus A21', International Journal of Oncology, 26 1471-1476 (2005) [C1]
2005	Grissell Terry Vincent, Powell Heather, Shafren Darren Raymond, Boyle Michael J, Hensley Michael John, Jones Peter Dominic, Whitehead Bruce Foster, Gibson Peter Gerard, 'Interleukin-10 gene expression in acute virus-induced asthma', American Journal of Respiratory and Critical Care Medicine, 172 433-439 (2005) [C1]
2005	Shafren Darren Raymond, Sylvester Dianne Elizabeth, Johansson Eva Susanne, Campbell I G, Barry Richard Desmond, 'Oncolysis of human ovarian cancers by echovirus type 1', International Journal of Cancer, 115 320-328 (2005) [C1]
2004	Hansbro Nicole Gower, Beagley Leone G, Christiansen Dale, Loveland Bruce E, Johansson Eva Susanne, Beagley Kenneth William, Barry Richard Desmond, Shafren Darren Raymond, 'Novel role for decay-accelerating factor in Coxsackievirus A21-mediated cell infectivity', Journal of Virology, 78 12677-12682 (2004) [C1]
2004	Hansbro Nicole Gower, Johansson Eva Susanne, Au Gough Geoffrey, Lindberg Am, Barry Richard Desmond, Shafren Darren Raymond, 'Enterovirus capsid interactions with decay-accelerating factor mediate lytic cell infection', Journal of Virology, 78 1431-1439 (2004) [C1]
2004	Johansson Es, Ekstrom J-O, Shafren Darren Raymond, Frisk G, Hyypia T, Edman K, Lindberg Am, 'Cell culture propagation and biochemical analysis of the Ljungan virus prototype strain', Biochemical and Biophysical Research Communications, 317 1023-1029 (2004) [C1]
2004	Johansson Eva Susanne, Xing L, Cheng Rh, Shafren Darren Raymond, 'Enhanced cellular receptor usage by a bioselected variant of Coxsackievirus A21', Journal of Virology, 78, No.22 12603-12612 (2004) [C1]
2004	Shafren Darren Raymond, Au Gough Geoffrey, Nguyen Tam, Barry Richard Desmond, Hansbro Nicole Gower, Harvey Erin Susannah, Beagley Leone, Johansson Eva Susanne, Hersey Peter, 'Systemic therapy of malignant human melanoma tumors by a common cold-producing enterovirus, Coxsackievirus A21', Clinical Cancer Research, 10 53-60 (2004) [C1]
2003	Johansson Susanne E, Niklasson Bo, Tesh Robert, Shafren Darren Raymond, Travassos Amelia P A, Lindberg Michael A, 'Molecular characterization of M1146, an American isolate of Ljungan virus (LV) reveals the presence of a new LV genotype', Journal of General Virology, 84 837-844 (2003) [C1]
2000	Shafren Darren Raymond, Dorahy D J, Thorne R F, Barry Richard Desmond, 'Cytoplasmic interactions between decay-accelerating factor and intercellular adhesion molecule-1 are not required for coxsackievirus A21 cell infection', Journal of General Virology, 81 889-894 (2000) [C1]
2000	Thorne R F, Marshall J F, Shafren Darren Raymond, Gibson P G, Hart I R, Burns G F, 'The integrins alpha 3 beta 1 and alpha 6 beta 1 physically and functionally associate with CD36 in human melanoma cells', Journal of Biological Chemistry, 275 (45) 35264-35275 (2000) [C1]
1999	Shafren Darren Raymond, Gardner J, Mann Vh, Antalis Tm, Suhrbier A, 'Picornavirus receptor down-regulation by plasminogen activator inhibitor type 2', Journal of Virology, 73,No.9 7193-7198 (1999) [C1]
1998	Shafren Darren Raymond, 'Viral cell entry induced by cross-linked decay-accelerating factor', Journal of Virology, 72(11) 9407-9412 (1998) [C1]
1998	Shafren Darren Raymond, Dorahy Dj, Thorne Rf, Kinoshita T, Barry Rd, Burns Gordon Frood, 'Antibody binding to individual short consensus repeats of decay-accelerating factor enhances enterovirus cell attachment and infectivity', The Journal of Immunology, 160 2318-2323 (1998) [C1]

Conference Publication (12 outputs)

Extract of Paper (E3) (12 outputs)

Year	Citation	Nova
2011	Shafren Darren Raymond, Au Gough Geoffrey, Davies Bronwyn, Chan Eric, Stewart Jaclyn, 'Pre-clinical oncolytic activity of coxsackievirus a21 in pancreatic cancer', Annals of Oncology, Barcelona, Spain (2011) [E3]
2011	Shafren Darren Raymond, Farrelly M, Croft Amanda J, Davies B, Stewart J, Ingham R, Quah M Y, Au Gough Geoffrey, Hersey Peter, 'CAVATAK (Coxsackievirus A21) displays potent oncolytic activity in BRAFV600E mutant melanoma cells resistant to selective BRAF kinase inhibitors', Pigment Cell & Melanoma Research, Tampa, FL (2011) [E3]
2011	Yee Yvonne W Vern, Chan Su Han Eric, Shafren Darren Raymond, Au Gough Geoffrey, 'Oncolytic activity of coxsackievirus A21 in human lung cancer: A novel targeted anti-cancer strategy', Journal of Thoracic Oncology, Amsterdam, The Netherlands (2011) [E3]
2010	Shafren Darren Raymond, Hersey Peter, Smithers Mark, 'Phase I evaluation of the intralesional administration of the oncolytic Picornavirus, Coxsackievirus A21 (CAVATAKTM) in patients with late stage melanoma', Melanoma 2010 Congress. Oral and Poster Abstracts, Sydney, NSW (2010) [E3]
2007	Skelding Kathryn Anne, Johansson Eva Susanne, Au Gough Geoffrey, Barry Richard Desmond, Shafren Darren Raymond, 'CAVATAK TM has anti-cancer properties against human metastatic breast cancer', Fourth International Conference on Oncolytic Viruses as Cancer Therapeutics, Carefree, Arizona (2007) [E3]
2007	Wark Peter Alexander, Grissell Terry Vincent, Davies B, Mimica J, Oldham R, Shafren Darren Raymond, Gibson Peter Gerard, 'Bronchial epithelial cell (BEC) response to clinical rhinovirus (clin-RV) isolates from ASTHMATICS compared to laboratory (lab-RV) strains', American Journal of Respiratory and Critical Care Medicine (American Thoracic Society 2007 International Conference Abstracts), San Francisco (2007) [E3]
2006	Au Gough Geoffrey, Johansson Eva Susanne, Berry Linda, Skelding Kathryn Anne, Haley Erin Susannah, Barry Richard Desmond, Shafren Darren Raymond, 'Coxsackievirus A21 as an oncolytic virotherapy agent for human cancers', Northern Lights EUROPIC 2006, Inari, Finland (2006) [E3]
2006	Grissell Terry Vincent, Davies B, Mimica J L, Shafren Darren Raymond, Gibson Peter Gerard, Wark Peter Alexander, 'Bronchial epithelial cell response to clinical rhinoviruses isolated from asthmatics compared to laboratory rhinovirus strains', Respirology, Canberra (2006) [E3]
2006	Wark Peter Alexander, Wood Lisa Gai, Grissell Terry Vincent, Davies B, Shafren Darren Raymond, Powell Helen Gaye, Hensley Michael John, Gibson Peter Gerard, 'Acute virus-induced asthma is characterised by increased expression of toll-like receptors (TLR)-2', Respirology, Canberra (2006) [E3]
2005	Berry Linda J, Haley Erin Susannah, Skelding Kathryn Anne, Au Gough Geoffrey, Barry Richard Desmond, Shafren Darren Raymond, 'Oncolytic activity of enteroviruses across a spectrum of human cancer types', Third Annual Australian Virology Group Meeting, Phillip Island, VIC (2005) [E3]
2005	Shafren Darren Raymond, Au Gough Geoffrey, Berry Linda J, Haley Erin Susannah, Skelding Kathryn Anne, Barry Richard Desmond, 'The human enterovirus, Coxsackievirus A21, exhibits oncolytic activity across a spectrum of cancer types', Proceedings of the 96th American Association for Cancer Research Annual Meeting, Anaheim, California (2005) [E3]
2004	Skelding Kathryn Anne, Haley Erin Susannah, Shafren Darren Raymond, Barry Richard Desmond, 'Viral oncolysis of human breast cancer', The Hunter Medical Research Institute Inaugural Cancer Conference, - (2004) [E3]