Prof. Alistair Sim

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Email	Alistair.Sim@newcastle.edu.au

Highlighted Publications

Year	Citation	Nova
2003	Baldwin Monique Louise, Rostas John Andrew, Sim Alistair Thomas, 'Two modes of excytosis from synaptosomes are differentially regulated by protein phosphatase types 2A and 2B', Journal of Neurochemistry, 85 1190-1199 (2003) [C1]
2002	Holst J, Sim Alistair Thomas, Ludowyke Ri, 'Protein Phosphatases 1 and 2A Transiently Associate with Myosin during the Peak Rate of Secretion from Mast Cells', Molecular Biology of the Cell, 13 1083-1098 (2002) [C1]
2001	Michell Bj, Chen Z-P, Tiganis T, Stapleton D, Katsis F, Power Da, Sim Alistair Thomas, Kemp Be, 'Coordinated Control of Endothelial Nitric-oxide Synthase Phosphorylation by Protein Kinase C and the cAMP-dependent Protein Kinase', Journal of Biological Chemistry, 276 17625-17628 (2001) [C1]
2001	Schillace Rv, Voltz Jw, Sim Alistair Thomas, Shenolikar S, Scott Jd, 'Multiple Interactions within the AKAP220 Signaling Complex Contribute to Protein Phosphatase 1 Regulation', Journal of Biological Chemistry, 276 No. 15 12128-12134 (2001) [C1]

Publications

For items published while at an institution other that the University of Newcastle, details are shown in italics.

Click on a category title below to expand the list of citations for that specific category.

Journal Articles (25 outputs)

Refereed Article in a Scholarly Journal (C1) (25 outputs)

Year	Citation	Nova
2011	Verrills Nicole Margaret, Irwin Jennifer Anne, He Xiao Yan, Wood Lisa Gai, Powell Heather, Simpson Jodie Louise, McDonald Vanessa Marie, Sim Alistair Thomas, Gibson Peter Gerard, 'Identification of novel diagnostic biomarkers for asthma and chronic obstructive pulmonary disease', American Journal of Respiratory and Critical Care Medicine, 183 1633-1643 (2011) [C1]
2010	Kranias Gregory, Watt Lauren, Carpenter Helen Christine, Holst Jeff, Ludowyke Russell, Strack Stefan, Sim Alistair Thomas, Verrills Nicole Margaret, 'Protein phosphatase 2A carboxymethylation and regulatory B subunits differentially regulate mast cell degranulation', Cellular Signalling, 22 1882-1890 (2010) [C1]
2010	Roberts Kathryn Grace, Smith Amanda Melanie, McDougall Fiona Karen, Carpenter Helen Christine, Horan Martin Patrick, Neviani Paolo, Powell Jason A, Thomas Daniel, Guthridge Mark A, Perrotti Danilo, Sim Alistair Thomas, Ashman Leonie Kay, Verrills Nicole Margaret, 'Essential requirement for PP2A inhibition by the oncogenic receptor c-KIT suggests PP2A reactivation as a strategy to treat c-KIT+ cancers', Cancer Research, 70 5438-5447 (2010) [C1]
2006	Baldwin Monique Louise, Cammarota Martin Pablo, Sim Alistair Thomas, Rostas John Andrew, 'Src family tyrosine kinases differentially modulate exocytosis from rat brain nerve terminals', Neurochemistry International, 49 80-86 (2006) [C1]
2006	Migues Paola Virginia, Lehmann Ingo Tobias, Fluechter Lisa, Cammarota Martin Pablo, Gurd J W, Sim Alistair Thomas, Dickson Phillip Wesley, Rostas John Andrew, 'Phosphorylation of CaMKII at Thr253 occurs in vivo and enhances binding to isolated postsynaptic densities', Journal of Neurochemistry, 98 289-299 (2006) [C1]
2006	Sim Alistair Thomas, Herd Lynn Michelle, Proctor D T, Baldwin Monique Louise, Meunier F A, Rostas John Andrew, 'High throughput analysis of endogenous glutamate release using a fluorescence plate reader', Journal of Neuroscience Methods, 153 43-47 (2006) [C1]
2006	Sim Alistair Thomas, Ludowyke Russell I, Verrills Nicole Margaret, 'Mast cell function: Regulation of degranulation by serine/threonine phosphatases', Pharmacology & Therapeutics, 112 425-439 (2006) [C1]
2003	Baldwin Monique Louise, Rostas John Andrew, Sim Alistair Thomas, 'Two modes of excytosis from synaptosomes are differentially regulated by protein phosphatase types 2A and 2B', Journal of Neurochemistry, 85 1190-1199 (2003) [C1]
2003	Bevilaqua Lia, Cammarota Martin Pablo, Dickson Phillip Wesley, Sim Alistair Thomas, Dunkley Peter Robert, 'Role of protein phosphatase 2C from bovine adrenal chromaffin cells in the dephosphorylation of phospho-serine 40 tyrosine hydroxylase', Journal of Neurochemistry, 85 1368-1373 (2003) [C1]
2003	Sim Alistair Thomas, Baldwin Monique Louise, Rostas John Andrew, Holst Jeff, Ludowyke Russell I, 'The role of serine/threonine protein phosphatases in exocytosis', Biochemical Journal, 373 641-659 (2003) [C1]
2002	Holst J, Sim Alistair Thomas, Ludowyke Ri, 'Protein Phosphatases 1 and 2A Transiently Associate with Myosin during the Peak Rate of Secretion from Mast Cells', Molecular Biology of the Cell, 13 1083-1098 (2002) [C1]
2002	Leal Rb, Sim Alistair Thomas, Goncalves Cas, Dunkley Peter Robert, 'Tyrosine Hydroxylase Dephosphorylation by Protein Phosphatase 2A in Bovine Adrenal Chromaffin Cells', Neurochemical Research, 27, No 3 207-213 (2002) [C1]
2002	McCluskey A, Keane Ma, Walkom Cc, Bowyer Mc, Sim Alistair Thomas, Young Dj, Sakoff Ja, 'The First Two Cantharidin Analogues Displaying PP1 Selectivity', Bioorganic & Medicinal Chemistry Letters, 12 391-393 (2002) [C1]
2002	McCluskey A, Sim Alistair Thomas, Sakoff Ja, 'Serine-Threonine Protein Phosphatase Inhibitors: Development of Potential Therapeutic Strategies', Journal of Medicinal Chemistry, 45, No 6 1151-1175 (2002) [C1]
2002	Sim Alistair Thomas, Ludowyke Ri, 'The Complex Nature of Protein Phosphatases', IUBMB Life, 53 283-286 (2002) [C1]
2001	Michell Bj, Chen Z-P, Tiganis T, Stapleton D, Katsis F, Power Da, Sim Alistair Thomas, Kemp Be, 'Coordinated Control of Endothelial Nitric-oxide Synthase Phosphorylation by Protein Kinase C and the cAMP-dependent Protein Kinase', Journal of Biological Chemistry, 276 17625-17628 (2001) [C1]
2001	Schillace Rv, Voltz Jw, Sim Alistair Thomas, Shenolikar S, Scott Jd, 'Multiple Interactions within the AKAP220 Signaling Complex Contribute to Protein Phosphatase 1 Regulation', Journal of Biological Chemistry, 276 No. 15 12128-12134 (2001) [C1]
2001	Sim Alistair Thomas, 'Protein Phosphatases: Regulating the Regulators', Australian Biochemist, 32 No. 1 13-15 (2001) [C1]
2000	Lengyel Imre, Fieuw-Makaroff Sabine, Hall Alison Louise, Sim Alistair Thomas, Rostas John Andrew, Dunkley Peter Robert, 'Modulation of the Phosphorylation and Activity of Calcium/Calmodulin-Dependent Protein Kinase II by Zinc', Journal of Neurochemistry, 75 No. 2 594-605 (2000) [C1]
2000	Ludowyke R I, Holst J, Mudge L-M, Sim Alistair Thomas, 'Transient Translocation and Activation of Protein Phosphatase 2A during Mast Cell Secretion', The Journal of Biological Chemistry, 275 No. 9 March 3 6144-6152 (2000) [C1]
2000	McCluskey A, Bowyer M C, Collins Elizabeth, Sim Alistair Thomas, Sakoff J A, Baldwin Monique Louise, 'Anhydride Modified Cantharidin Analogues: Synthesis, Inhibition of Protein Phosphatases 1 and 2A and Anticancer Activity', Bioorganic & Medicinal Chemistry Letters, 10 1687-1690 (2000) [C1]
2000	McCluskey A, Keane M A, Mudgee L-M, Sim Alistair Thomas, Sakoff J, Quinn R J, 'Anhydride modified cantharidin analogues. Is ring opening important in the inhibition of protein phosphatase 2A?', European Journal of Medicinal Chemistry, 35 957-964 (2000) [C1]
1999	Sim Alistair Thomas, Scott Jd, 'Targeting of PKA, PKC and protein phosphatases to cellular microdomains', Cell Calcium, 26 No. 5 209-217 (1999) [C1]
1998	Capon R J, Rooney F, Murray L M, Collins Elizabeth, Sim Alistair Thomas, Rostas John Andrew, Butler M S, Carroll A R, 'Dragmacidins: New protein phosphatase inhibitors from a Southern Australian deep-water marine sponge Spongosorites sp', Journal of Natural Products, 61 660-662 (1998) [C1]
1998	Sim Alistair Thomas, Collins Elizabeth, Mudge L M, Rostas John Andrew, 'Developmental regulation of protein phosphatase types 1 and 2A in post-hatch chicken brain', Neurochemical Research, 23(4) 487-491 (1998) [C1]

Review (1 outputs)

A Substantial Review of an Entire Field of Study (D1) (1 outputs)

Year	Citation	Nova
2003	Sim Alistair Thomas, Holst Jeff, Ludowyke Russell I, 'Protein Phosphatase Translocation in RBL-2H3 Cells', Methods in Enzymology (2003) [D1]

Conference Publication (10 outputs)

Extract of Paper (E3) (10 outputs)

Year	Citation	Nova
2010	Verrills Nicole Margaret, Roberts Kathryn Grace, Smith Amanda Melanie, McDougall Fiona Karen, Carpenter Helen Christine, Neviani Paolo, Sim Alistair Thomas, Perrotti Danio, Ashman Leonie Kay, 'Targeting the tumour suppressor, PP2A, as a novel therapy for acute myeloid leukaemia', Sydney Cancer Conference 2010. Profiling Risk, Personalising Treatment and Predicting Outcomes. Conference Program and Abstract Book, Sydney, NSW (2010) [E3]
2009	Kranias Gregory, Cottrell L F, Carpenter Helen Christine, Sim Alistair Thomas, Verrills Nicole Margaret, 'Protein phosphatase 2A carboxymethylation and regulatory B subunits differentially regulate mast cell degranulation', FEBS Journal, Prague, Czech Republic (2009) [E3]
2009	Skelding Kathryn Anne, Liao X, Verrills Nicole Margaret, Fluechter Lisa, Sim Alistair Thomas, Dickson Phillip Wesley, Rostas John Andrew, 'Functional consequences of CaMKII phosphorylation at THR253 in neurons', ANS 2009 Abstracts: Posters, Canberra, ACT (2009) [E3]
2008	Skelding Kathryn Anne, Verrills Nicole Margaret, Fluechter Lisa, Sim Alistair Thomas, Dickson Phillip Wesley, Rostas John Andrew, 'Development of a novel method for the identification of CaMKII binding proteins', Journal of Neurochemistry, Shanghai, China (2008) [E3]
2008	Skelding Kathryn Anne, Verrills Nicole Margaret, Fluechter Lisa, Sim Alistair Thomas, Dickson Phillip Wesley, Rostas John Andrew, 'Identification of CaMKII binding proteins in brain sensitive to CaMKII phosphorylation state', Proceedings of the Australian Neuroscience Society, Hobart, TAS (2008) [E3]
2007	Roberts Kathryn Grace, Ashman Leonie Kay, Sim Alistair Thomas, Verrills Nicole Margaret, 'Regulation of protein phosphatase 2A (PP2A) B subunits by Bcr/Abl: Potential targets for chronic myeloid leukemia', AACR Meeting Abstracts Online (Abstracts of the 98th AACR Annual Meeting), Los Angeles (2007) [E3]
2006	Rostas John Andrew, Migues Paola Virginia, Fluechter Lisa, Dickson Phillip Wesley, Sim Alistair Thomas, Rawoff S, Bissoon N, Wallace M C, Gurd James Wood, 'Phosphorylation of CAMKII at T253 induced by transient global ischaemia', Proceedings of the Australian Neuroscience Society, Sydney (2006) [E3]
2006	Verrills Nicole Margaret, Carpenter Helen Christine, Sim Alistair Thomas, 'Disruption of Actin-containing Protein Phosphatase 2A Complexes Regulates Cell Motility in Neuroblastoma Cells', Molecular & Cellular Proteomics, California, USA (2006) [E3]
2004	Migues Paola Virginia, Sim Alistair Thomas, Rostas John Andrew, 'Changes in KCI-induced phosphorylation of AMPA and NMDA receptors during chicken brain maturation', Journal of Neurochemistry, Hong Kong (2004) [E3]
2004	Rostas John Andrew, Baldwin Monique Louise, Cammarota Martin Pablo, Sim Alistair Thomas, 'The regulation of synaptosomal exocytosis by Src tyrosine kinases', Journal of Neurochemistry, Hong Kong (2004) [E3]

The University of Newcastle, Australia