The University of Newcastle, Researcher report.

Researcher: Conjoint A/Prof Renate Griffith
School: School of Environmental and Life Science
Commenced with Institution: 22-JAN-2001
Personal URL:

Funded Projects

Please note, only grants administered through the University of Newcastle Research Office are recorded here. For a more complete picture of the researcher's grant history a Personal URL may be supplied, above.

Research Team Initial Year Duration (Years) Funding Body/Client Award Type Title of Project Collaborating Partners Total Cash $ Total Inkind $
Conjoint A/Prof Renate Griffith 2007 1 University of Newcastle Travel - Travel Grant AIMECS 07 (6th AFMC International Medicinal Chemistry Sympoium), Istanbul Turkey, 8/7/2007 - 11/7/2007   2500  
Conjoint A/Prof Renate Griffith;Professor Leonie Ashman 2006 2 University of Newcastle Project - Pilot Grant Structural studies of the binding of clinically relevant small-molecule injibitors to wildtype and mutant receptor tyrosine kinases   20000  
Assoc. Prof Peter Lewis;Conjoint A/Prof Renate Griffith;Dr Richard Lewis 2006 3 Australian Research Council Project - Discovery Projects Structural analysis and functional inactivation of bacterial transcription complexes   273000  
Conjoint A/Prof Renate Griffith 2005 1 University of Newcastle Travel - Travel Grant CONNECT 2005 - Chemical Challenges for the 21st Century. The 12th RACI National Convention, 3-7 July 2005   635  
Conjoint A/Prof Renate Griffith 2005 1 University of Newcastle Equipment/Infrastructure - Research Infrastructure Block Grant (RIBG) 2005 RIBG allocation   19000  
Assoc. Prof Eileen McLaughlin;Conjoint A/Prof Renate Griffith 2005 1 University of Newcastle Project - Project Grant SOCS-4 - modulation of cytokine and growth factor signalling in the mammalian ovary   10000  
Assoc. Prof Peter Lewis;Conjoint A/Prof Renate Griffith 2005 1 University of Newcastle Project - Project Grant Structural Analysis and Functional Inactivation of Bacillus Subtilis RNA Polymerase   13000  
Laureate Pr Robert Aitken;Assoc. Prof Eileen McLaughlin;Assoc. Prof Peter Lewis;Conjoint A/Prof Renate Griffith;Professor Raymond Rose;Emeritus Pr John Patrick;Assoc. Prof David McCurdy;Assoc. Prof Adam McCluskey;Professor Ellak Von Nagy-Felsobuki;Professor Peter Dunkley;Assoc. Prof Phillip Dickson;Professor John Rostas;Professor Leonie Ashman;Professor Gordon Burns;Professor Paul Foster;Conjoint Pr Peter Gibson;Professor Roger Smith;Professor Alistair Sim;Dr Paul Tooney;Dr Fraser Ross 2005 1 Australian Research Council Equipment/Infrastructure - Linkage Infrastructure Equipment & Facilities (LIEF) High throughput proteomics - Thermo Finnigan ProteomeX LCQ Integrated Proteomicis Workstation   207189  
Assoc. Prof Peter Lewis;Conjoint A/Prof Renate Griffith 2004 1 University of Newcastle Project - Project Grant Investigation of transcript factor interaction with RNA polymerase in Bacillus subtilis   6000  
Laureate Pr Robert Aitken;Conjoint A/Prof Renate Griffith 2003 3 National Health & Medical Research Council Project - Project Grant Redox cycling of quinones by human spermatozoa: a potential strategy for the dual regulation of fertility and STDs   300000  
Assoc. Prof Peter Lewis;Conjoint A/Prof Renate Griffith 2003 1 University of Newcastle Project - Project Grant Protein-protein interactions in Bacillus subtilis.   8500  
Conjoint A/Prof Renate Griffith 2003 1 National Health & Medical Research Council Equipment/Infrastructure - Equipment Grant 1. Silicon Graphics Octane 2 Visual Workstation; 2. Additional licenses for Tripos Drug Discovery software; 3. Spartan 02 molecular modelling software   16000  
Assoc. Prof Peter Lewis;Conjoint A/Prof Renate Griffith 2002 1 University of Newcastle Project - Project Grant Investigation of Protein-Protein Interactions in Bacillus subtillis   10000  
Conjoint A/Prof Renate Griffith 2002 1 University of Newcastle Travel - Travel Grant 5th Australia / Japan Symposium on Drug Design Nara, Japan, 13 - 16 May 2002   1842  
Conjoint A/Prof Renate Griffith 2001 3 National Health & Medical Research Council Project - Project Grant (SHARED) Integrated Drug Design for a New Generation of Adrenergic Therapeutics.   118000  
Conjoint A/Prof Renate Griffith 2001 1 University of Newcastle Travel - Travel Grant ACS 221st National Meeting, USA 1-5 April 2001   2229  
Conjoint A/Prof Renate Griffith 2000 1 University of Newcastle Project - New Staff Grant Novel Integrated Computer-Aided Molecular Design Methodologies.   15000  

Research Higher Degree Supervision

For a more complete picture of the researcher's supervision history a Personal URL may be supplied at the top of this page.

Current Student Supervision

Program Supervision Level Research Topic
PhD (Biological Sciences) Co-Supervisor Design and testing of anti-RNA polymerase compounds
PhD (Biological Sciences) Principal Supervisor Inhibitors of KIT Receptor Tyrosine Kinase
PhD (Biological Sciences) Sole Supervisor Computational Investigation into the Human alpha-1 Adrenoceptors
PhD (Medical Biochemistry) Co-Supervisor Small Molecule Inhibitors of Oncogenic Protein Kinases
PhD (Medical Biochemistry) Co-Supervisor C-Kit Polymorphism in Pediatric Mastocytosis and Comparative Analysis of Wild Type c-KIT and the Asp816Val Mutant

Total Equivalent Full-time Student Units (EFTSU):

Supervision Level EFTSU
PhD 1.500

Student Completions

NB - the completions shown here are only those for the University of Newcastle obtained since 2001.

Program Year Research Topic
PhD (Biological Sciences) 2007 Mechanisms of Quinone Spermostatic Activity and Toxicity

Research Publications

Please note, the publications listed here:
(1) relate to the researcher's position at the University of Newcastle only
(2) are for selected categories of publications, and
(3) relate to publication year 1998, onwards.
For a more complete picture of the researcher's publication history a Personal URL may be supplied at the top of this page.

Journal Article

Foster Rowan Clare, Byrnes Ellen Maree, Meldrum C, Griffith Renate, Ross G, Upjohn E, Braue A, Scott Rodney, Varigos G, Ferrao Petranel Theresa, Ashman Leonie Kay, ’Association of paediatric mastocytosis with a polymorphism resulting in an amino acid substitution (M541L) in the transmembrane domain of c-KIT’, British Journal of Dermatology, 159 1160-1169 (2008) [C1]

Aitken Robert John, Hughes Louise Mary, Griffith Renate, Baker Mark Andrew, ’Bridging the gap between male and female fertility control; contraception-on-demand’, Contraception, 78 S28-S35 (2008) [C1]

Garner J, Deadman J, Rhodes D, Griffith Renate, Keller P A, ’A new methodology for the simulation of flexible protein-ligand interactions’, Journal of Molecular Graphics and Modelling, 26 187-197 (2007) [C1]

Gordon C P, Griffith Renate, Keller P A, ’Control of HIV through the inhibition of HIV-1 integrase: A medicinal chemistry perspective’, Medicinal Chemistry, 3 199-220 (2007) [C1]

Hughes Louise, Wingate Jordana Kate, Griffith Renate, Aitken Robert John, ’Modelling and measuring redox cycling and cytotoxicity of quinones’, Drug Metabolism Letters, 1 245-253 (2007) [C2]

Roberts Kathryn Grace, Odell Adam Francis, Byrnes Ellen Maree, Baleato Rosa, Griffith Renate, Lyons A B, Ashman Leonie Kay, ’Resistance to c-KIT kinase inhibitors conferred by V654A mutation’, Molecular Cancer Therapeutics, 6 1159-1166 (2007) [C1]

Hughes L M, Griffith Renate, Aitken Robert John, ’The search for a topical dual action spermicide/microbicide’, Current Medicinal Chemistry, 14 775-786 (2007) [C1]

MacDougall Iain James Ashford, Griffith Renate, ’Selective pharmacophore design for adrenoceptor subtypes’, Journal of Molecular Graphics and Modelling, 25 146-157 (2006) [C1]

Griffith Renate, Brown Michael Nicholas, McCluskey Adam, Ashman Leonie Kay, ’Small molecule inhibitors of protein kinases in cancer - How to overcome resistance’, Mini-Reviews in Medicinal Chemistry, 6 1101-1110 (2006) [C1]

Yepuri N R, Haritakul R, Griffith Renate, Leach S P, Keller P A, ’The synthesis and testing of arenearylpyrimidylmethanes as antimalarial agents’, ChemMedChem, 1 715-717 (2006) [C2]

Griffith Renate, Luu T T T, Garner J, Keller P A, ’Combining structure-based drug design and pharmacophores’, Journal of Molecular Graphics & Modelling, 23 439-446 (2005) [C1]

MacDougall Iain James Ashford, Lewis Peter John, Griffith Renate, ’Homology modelling of RNA polymerase and associated transcription factors from Bacillus subtilis’, Journal of Molecular Graphics & Modelling, 23 297-303 (2005) [C1]

Foster Rowan Clare, Griffith Renate, Ferrao Petranel Theresa, Ashman Leonie Kay, ’Molecular basis of the constitutive activity and STI571 resistance of Asp816Val mutant KIT receptor tyrosine kinase’, Journal of Molecular Graphics and Modelling, 23 139-152 (2004) [C1]

McGinty Susan J, Finch Angela, Griffith Renate, Graham Robert M, Bremmer John B, ’Synthesis and biological evaluation of bicyclic and tricyclic substituted nortropane derivatives: discovery of a novel selective alpha 1D-adrenergic receptor ligand’, Bioorganic and Medicinal Chemistry, 12 5639-5650 (2004) [C1]

Faragalla Jane, Bremner John, Brown David, Griffith Renate, Heaton Andrew, ’Comparative pharmacophore development for inhibitors of human and rat 5-α-reductase’, Journal of Molecular Graphics & Modelling, 83-92 (2003) [C1]

Keller Paul A, Birch Chris, Leach Scott P, Tyssen David, Griffith Renate, ’Novel pharmacophore-based methods reveal gossypol as a reverse transcriptase inhibitor’, Journal of Molecular Graphics & Modelling, 365-373 (2003) [C1]

Bremner Jb, Castle K, Griffith Renate, Keller Pa, Ridley Dd, ’Mining the chemical abstracts database with pharmacophore-based queries’, Journal of Molecular Graphics & Modelling, 21 185-194 (2002) [C1]

Conference Publication

Griffith Renate, MacDougall Iain James Ashford, ’Pharmacophores for selective monoamine transporter ligands’, AIMECS 07. 6th International Medicinal Chemistry Symposium. Posters and Poster Groups, Istanbul, Turkey (2007) [E3]

Johnston Elecia Brooke, Griffith Renate, Lewis Peter John, ’The design and testing of inhibitors of interactions between essential transcription factors and RNA polymerase’, BacPath 9 : The Molecular Biology of Bacterial Pathogens. Abstracts, Lorne, VIC (2007) [E3]

Johnston Elecia Brooke, Griffith Renate, Lewis Peter John, ’The design and testing of inhibitors of interactions between essential transcription factors and RNA polymerase’, 32nd Lorne Conference on Protein Structure and Function. Abstracts, Lorne, Vic (2007) [E3]

Bremmer John B, Faragalla Jane, Griffith Renate, Heaton Andrew, ’Comparative inhibitory pharmacophore development for human and rat 5-alpha-reductase’, MM2004: 9th Molecular Modelling Workshop, Sydney, Australia (2004) [E3]

Griffith Renate, Foster Rowan Clare, Brown Michael Nicholas, Ashman Leonie Kay, ’Design of inhibitors of the KIT receptor tyrosine kinase’, EuroQSAR 2004 Proceedings, Instanbul, Turkey (2004) [E1]

Garner James, Griffith Renate, Keller Paul A, ’Developing a molecular modelling technique for flexible enzyme targets - new anti-HIV agents’, MM2004: 9th Molecular Modelling Workshop, Sydney, Australia (2004) [E3]

Martin Shelagh, MacDougall Iain James Ashford, Griffith Renate, Lewis Peter John, ’Investigation of the interactions between transcription factor NusA with RNA polymerase in Bacillus subtilis’, ASM 2004 Sydney National Conference, Sydney, Australia (2004) [E3]

Foster Rowan Clare, Griffith Renate, Ferrao Petranel Theresa, Ashman Leonie Kay, ’Molecular Modelling of c-Kit Kinase Domains’, MM2004: 9th Molecular Modelling Workshop, Sydney, Australia (2004) [E3]

De Iuliis Geoffry Nunzio, MacDougall Iain James Ashford, Griffith Renate, ’Molecular modelling of alpha 1b and alpha 1d adrenoceptors and investigations into the effects of water and adrenaline’, MM2004: 9th Molecular Modelling Workshop, Sydney, Australia (2004) [E3]

MacDougall Iain James Ashford, Lewis Peter John, Griffith Renate, ’Molecular modelling of the RNA polymerase complex in Bacillus subtilis’, MM2004: 9th Molecular Modelling Workshop, Sydney, Australia (2004) [E3]

Gordon C P, Griffith Renate, Keller P A, ’Towards a working model of HIV-1 integrase’, MM2004: 9th Molecular Modelling Workshop, Sydney, Australia (2004) [E3]

Ashman Leonie Kay, Ferrao Petranel Theresa, Foster Rowan Clare, Griffith Renate, ’Analysis of the Structure of the Kinase Domain of the Stem Cell Factor Receptor Tyrosin Kinase (c-Kit) - Constitutive Activation by a D816V Mutation and Inhibition by STI571’, Fifth AFMC International Medicinal Chemistry Symposium AIMECS 03, Kyoto, Japan (2003) [E3]

De Iuliis Geoffry Nunzio, Griffith Renate, ’Molecular Dynamics Studies On A Model Of The a1b-Adrenergic Receptor: The Effects Of Water, Adrenaline And Site Directed Mutagenesis’, TOMECS International Symposium AIMECS 03 Post Symposium Meeting Abstracts, Sunforte, Japan (2003) [E3]

Bremner John B, Castle Kao, Fraser Barbara Anne, Griffith Renate, Keller Paul A, ’Telomerase - a new target for antimalarial agents?’, Bioactive Discovery in the New Millennium, Lorne, Victoria (2003) [E3]

Bremner Jb, Castle K, Griffith Renate, Keller Pa, Ridley Dd, ’Mining the chemical abstracts database with pharmacophore-based queries’, Fifth Australia/Japan Symposium on Drug Design and Development, Nara, JAPAN (2002) [E3]

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