The Centre for Chemical Biology seeks to unravel the causes of disease by identifying crucial biological targets and pioneering the rapid development of novel drugs for the fight against disease.

Priority Research Centre for
CHEMICAL BIOLOGY AND
CLINICAL PHARMACOLOGY

People

Directors

Professor Peter Lewis

Biological Sciences

Professor Peter Lewis' research career has focused on the gram positive bacterium Bacillus subtilis.es.

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Professor Jennifer Martin

Clinical pharmacology

Optimising choice, dose and timing of medicines for a particular patient are the focus of Professor Jennifer Martin's clinical work and research career.

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Researchers

Professor Adam McCluskey

Chemistry

Professor Adam McCluskey is the Director of the University of Newcastle’s Priority Research Centre for Chemical Biology. He is involved in research resulting in four key drug discovery areas being pursued: epilepsy, kidney disease, cancer, and anti-viral.

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Dr Jennette Sakoff

Chemistry

Dr Jennette Sakoff is an experienced cell biologist and Chief Hospital Scientist in the Department of Medical Oncology at the Calvary Mater Newcastle Hospital.  She has made significant contributions to cancer research particularly in the development of small molecules for the treatment of cancer. Areas of expertise includes cell culture, drug screening, cell biology, proteomics, cell cycle analysis, drug combination studies, clinical toxicity.

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Dr Ian Grainge

Biochemistry and Cell Biology

Dr Ian Grainge is interested in all aspects of how bacteria pass on their genetic information, from DNA replication to chromosome segregation and accurate cell division.

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Associate Professor Christopher Scarlett

Applied Sciences

Associate Professor Christopher Scarlett's research interests have primarily focused on signalling pathways in pancreatic cancer to identify novel therapeutic and chemopreventative strategies, as well as defining the role of bone marrow derived cells in the development of the normal pancreas, pancreatic injury and regeneration, and pancreatic cancer.

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Dr Shaun Roman

Biological Sciences

Dr Shaun Roman’s research expertise is in gene expression and regulation, focussing on the role of retinoids in regulating gene expression in breast cancer and including the initial description of the relationship between retinoid receptors and steroid hormone receptor status.

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Dr Michela Simone

Chemistry

Dr Michela Simone’s research interests lie under the broad umbrella of medicinal chemistry with a glycobiological spin! She is interested in the synthesis and evaluation of novel classes of glycosidase inhibitors from carbohydrate starting materials to molecular recognition and supramolecular chemistry. Recently she has also moved into the area of bioinorganic chemistry primarily as relating to cancer research, and the field of renewable energy from chemical manipulations of biomass.

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Dr Peter Galettis

Clinical Pharmacology

Dr Peter Galettis's research interests are entirely within the field of clinical pharmacology and toxicology, specializing in assay development for use in drug monitoring for the last 25 years, focussing on anticancer agents and drugs of abuse .

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Conjoint Professor Stephen Ackland

Pharmacy and Experimental Pharmacology

Conjoint Professor Stephen Ackland’s research expertise are in the areas of basic and clinical pharmacology of anticancer drugs, including drug measurement, pharmacokinetics pharmacodynamics, and relevant genetics/genomics. Clinical trials in cancer mainly medical oncology.

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Dr Clovia Holdsworth

Chemistry

Dr Clovia Holdsworth trained as a polymer chemist with considerable experience and knowledge in controlled free radical polymer synthesis with focus on polymer functionalisation, regulation of molecular weight and its distribution, and the use of these synthetic methodologies for the synthesis of specialised polymers for various applications.

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Dr Xiao Yang

Spanning all levels of biological organisation, Dr Xiao Yang's research into intricate antibiotic-disease relationships is helping to combat the spread of multi-drug resistant bacteria.

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Conjoint Professor Phillip Robinson

Conjoint Professor Phillip Robinson research focuses on understanding aspects of regulating nerve cell communication, principally the process of endocytosis and the protein dynamin, along with other nerve terminal proteins.

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