Dr Zoe Yates

Lecturer

School of Biomedical Sciences and Pharmacy (Applied Sciences)

Career Summary

Biography

Zoe is a Research Fellow in Human Molecular Nutrition in the Discipline of Applied Sciences, in the School of Environmental & Life Sciences.

Over the last decade I have developed a career in nutritional genetics. In 1999, I became a British Heart Foundation PhD Scholar at Leeds University, and as a graduate student studied the important interaction between folate status, single nucleotide polymorphisms (SNPs) of genes that code for B-vitamin dependent enzymes and human health. The focus of my research endeavours was the role of C677T MTHFR and vascular complications. Between 2005 and 2007 I worked at the University of Nottingham examining the biological basis of foetal programming and adult disease. The study investigated the early life programming of disease, addressing the molecular mechanisms that may link foetal nutrition to later life atherosclerosis. In particular, it considered the effect of maternal under-nutrition (particularly a low protein diet) and the effect of maternal hyperlipidaemia (induced by a high fat/high cholesterol diet) during pregnancy on the subsequent development of atherosclerosis in the offspring of apoE*Leiden mice.

Currently I am appointed as a University of Newcastle Research Fellow within the School of Environmental & Life Sciences, Ourimbah campus (commenced June 2007). The purpose of this appointment is to broaden the Molecular Nutrition research portfolio to encompass a range of degenerative disorders, both related to vascular disease and cancer. More specifically I aim to develop in vitro and in vivo methodologies that examine genomic integrity and provide a simple functional measure of nutritional adequacy along with a measure of modulatory pressures exerted by common SNPs in B-vitamin related genes. Essentially, my research interests cover nutritional biochemistry, molecular biology and genetics of disease processes, in particularly how folate bioavailability, metabolism, nutritional status and genetics modulate risk of serious human conditions such as heart disease, stroke, cancer, dementia, spina bifida and other conditions affecting pregnancy outcomes. In addition, I am interested in the very topical issues associated with mandatory fortification of grain at source with synthetic folic acid.

Since being in Australia I have been invited to speak at several conferences including the 3rd Asia Pacific Nutrigenomics Conference in Melbourne (2008) and the 2nd Meeting of Nutrition Society Australia (Newcastle, 2008). I have authored/co-authored over 35 peer-reviewed scientific publications including several in extremely high impact factor journals such as Nature Reviews Genetics, Lancet, and Journal of the National Cancer Institute, and also have a chapter in Folate and Development. Last year I obtained a Ramaciotti Foundation Establishment Grant to pursue my line of research, and in 2007 was successful in obtaining a University of Newcastle Strategic Pilot Grant to look at bitter taste phenotype, dietary pattern and nutritional genetics in the aetiopathology of human colonic adenoma/cancer.

My professional activities include being a committee member of Nutrition Society of Australia (Newcastle) and an active member of University of Newcastle's Institutional Biosafety Committee.

Research Expertise

Over the last decade I have developed a career in nutritional biochemistry, molecular biology and genetics of disease processes, in particularly how folate bioavailability, metabolism, nutritional status and genetics modulate risk of serious human conditions such as heart disease, stroke, cancer, dementia, spina bifida and other conditions affecting pregnancy outcomes.

An expert in several laboratory techniques.

Other research skills include; project design and management, article preparation and review, grant preparation and submission.



Teaching Expertise

To date has specialized in teaching Research Methods. Essentially providing a detailed view of the methods used in scientific research. Covering access to and critical evaluation of literature, design and conduct of experiments, handling and analysis of experimental data and the reporting and publication of results. Aspects such as generation and testing of hypotheses based on existing knowledge, generation of aims, animal and human ethics considerations and applications, health and safety issues, importance and choice of methodology including power analyses, preparation of data and statistical analyses, interpretation and publishing of results, the grant application process and the patent application process.

Also teach RHD & Honour students principles of good research practice within the laboratory.



Administrative Expertise

Laboratory management

Health & Safety



Collaborations

Research interests cover nutritional biochemistry, molecular biology and genetics of disease processes, in particularly how folate bioavailability, metabolism, nutritional status and genetics modulate risk of serious human conditions such as heart disease, stroke, cancer, dementia, spina bifida and other conditions affecting pregnancy outcomes.

I am also very interested in the topical issues associated with mandatory fortification of grain at source with synthetic folic acid.

In conjunction with the above I am interested in the biological basis of foetal programming and adult disease, particularly the molecular mechanisms that may link foetal nutrition to later life atherosclerosis.


Qualifications

  • PhD, University of Leeds - UK
  • Bachelor of Science (Honours), University of Leeds - UK

Keywords

  • Folic Acid
  • Genetic variations
  • Nutrition
  • Research Methods

Languages

  • English (Fluent)

Fields of Research

CodeDescriptionPercentage
110399Clinical Sciences not elsewhere classified55
111199Nutrition and Dietetics not elsewhere classified20
111599Pharmacology and Pharmaceutical Sciences not elsewhere classified25

Professional Experience

UON Appointment

DatesTitleOrganisation / Department
23/05/2015 - 24/05/2015Casual LecturerUniversity of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
1/01/2015 - LecturerUniversity of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
1/07/2013 - 31/12/2013Research AcademicUniversity of Newcastle
School of Medicine and Public Health
Australia
4/03/2013 - 21/06/2013Casual AcademicUniversity of Newcastle
School of Environmental and Life Sciences
Australia
21/07/2008 - 19/12/2008Casual AcademicUniversity of Newcastle
School of Environmental and Life Sciences
Australia

Academic appointment

DatesTitleOrganisation / Department
1/06/2007 - 1/06/2012Fellow UON
UoN Research Fellowship
University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
1/01/2005 - 1/05/2007Postdoctoral ResearcherThe University of Nottingham
Department of Nutritional Sciences
United Kingdom
1/12/2003 - 1/03/2004Research Assistant
Applied Sciences
University of Newcastle
School of Environmental and Life Sciences
Australia

Membership

DatesTitleOrganisation / Department
Member - Nutrition Society of Australia (Newcastle)Nutrition Society of Australia
Australia

Professional appointment

DatesTitleOrganisation / Department
1/03/2003 - 1/11/2003Research ScientistUniversity of Leeds
Unit of Peadiatrics, Obstetrics & Gynaecology
United Kingdom

Invitations

Participant

YearTitle / Rationale
20083rd Asia Pacific Nutrigenomics Conference
Organisation: Nutrigenomics & Nutrigenetics Description: An invited speaker and chair of a session. 30 minute presentation entitled "Folate and the C677T MTHFR variant - Impact on population health.

Speaker

YearTitle / Rationale
2010Nutrition Society Australia (Sydney AGM)
Organisation: Sydney Group Description: 45 minute seminar entitled "Folate - Nutrient - gene interactions. What does the future hold?
20082nd Meeting of Nutrition Society Australia
Organisation: Newcastle Group Description: Presented at the local Nutrition Society Australia meeting on Minor Nutrients - Major Impact. Expenses were paid.
Edit

Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Journal article (51 outputs)

YearCitationAltmetricsLink
2015Lucock M, Yates Z, Martin C, Choi J-H, Beckett E, Boyd L, et al., 'Methylation diet and methyl group genetics in risk for adenomatous polyp occurrence', BBA Clinical, 3 107-112 (2015)

Purpose: The aim of this study is to explore whether a methylation diet influences risk for adenomatous polyps (AP) either independently, or interactively with one-carbon metabolism-dependent gene variants, and whether such a diet modifies blood homocysteine, a biochemical phenotype closely related to the phenomenon of methylation. Methods: 249 subjects were examined using selective fluorescence, PCR and food frequency questionnaire to determine homocysteine, nine methylation-related gene polymorphisms, dietary methionine, 5-methyltetrahydrofolate, vitamins B6 and B12. Results: 1). Both dietary methionine and 5-methyltetrahydrofolate intake are significantly associated with plasma homocysteine. 2). Dietary methionine is related to AP risk in 2R3R-TS wildtype subjects, while dietary B12 is similarly related to this phenotype in individuals heterozygous for C1420T-SHMT, A2756G-MS and 844ins68-CBS, and in those recessive for 2R3R-TS. 3). Dietary methionine has a marginal influence on plasma homocysteine level in C1420T-SHMT heterozygotes, while B6 exhibits the same effect on homocysteine in C776G-TCN2 homozygote recessive subjects. Natural 5-methyltetrahydrofolate intake is interesting: Wildtype A1298C-MTHFR, heterozygote C677T-MTHFR, wildtype A2756G-MS and recessive A66G-MSR individuals all show a significant reciprocal association with homocysteine. 4). Stepwise regression of all genotypes to predict risk for AP indicated A2756G-MS and A66G-MSR to be most relevant (p= 0.0176 and 0.0408 respectively). Results were corrected for age and gender. Conclusion: A methylation diet influences methyl group synthesis in the regulation of blood homocysteine level, and is modulated by genetic interactions. Methylation-related nutrients also interact with key genes to modify risk of AP, a precursor of colorectal cancer. Independent of diet, two methylation-related genes (A2756G-MS and A66G-MSR) were directly associated with AP occurrence.

DOI10.1016/j.bbacli.2014.11.005
Co-authorsMark Lucock, Martin Veysey
2015Choi JH, Yates Z, Martin C, Boyd L, Ng X, Skinner V, et al., 'Genetic Variation in Glutamate Carboxypeptidase II and Interaction with Dietary Natural Vitamin C May Predict Risk for Adenomatous Polyp Occurrence.', Asian Pac J Cancer Prev, 16 4383-4386 (2015)
Author URL
Co-authorsMartin Veysey, Mark Lucock
2015Lucock M, Jones P, Martin C, Beckett E, Yates Z, Furst J, Veysey M, 'Vitamin D: Beyond Metabolism.', J Evid Based Complementary Altern Med, (2015)
DOI10.1177/2156587215580491Author URL
Co-authorsJohn Furst, Martin Veysey, Mark Lucock
2014Beckett EL, Yates Z, Veysey M, Duesing K, Lucock M, 'The role of vitamins and minerals in modulating the expression of microRNA.', Nutr Res Rev, 27 94-106 (2014) [C1]
DOI10.1017/S0954422414000043Author URL
Co-authorsMark Lucock, Martin Veysey
2014Beckett EL, Martin C, Duesing K, Jones P, Furst J, Yates Z, et al., 'Vitamin D Receptor Genotype Modulates the Correlation between Vitamin D and Circulating Levels of let-7a/b and Vitamin D Intake in an Elderly Cohort.', J Nutrigenet Nutrigenomics, 7 264-273 (2014)
DOI10.1159/000381676Author URL
Co-authorsJohn Furst, Martin Veysey, Mark Lucock
2014Beckett EL, Yates Z, Veysey M, Duesing K, Lucock M, 'The role of vitamins and minerals in modulating the expression of microRNA', Nutrition Research Reviews, 27 94-106 (2014) [C1]

A growing number of studies in recent years have highlighted the importance of molecular nutrition as a potential determinant of health and disease. In particular, the ability of micronutrients to regulate the final expression of gene products via modulation of transcription and translation is now being recognised. Modulation of microRNA (miRNA) by nutrients is one pathway by which nutrition may mediate gene expression. MiRNA, a class of non-coding RNA, can directly regulate gene expression post-transcriptionally. In addition, miRNA are able to indirectly influence gene expression potential at the transcriptional level via modulation of the function of components of the epigenetic machinery (DNA methylation and histone modifications). These mechanisms interact to form a complex, bi-directional regulatory circuit modulating gene expression. Disease-specific miRNA profiles have been identified in multiple disease states, including those with known dietary risk factors. Therefore, the role that nutritional components, in particular, vitamins and minerals, play in the modulation of miRNA profiles, and consequently health and disease, is increasingly being investigated, and as such is a timely subject for review. The recently posited potential for viable exogenous miRNA to enter human blood circulation from food sources adds another interesting dimension to the potential for dietary miRNA to contribute to gene modulation. © 2014 The Authors.

DOI10.1017/S0954422414000043
CitationsScopus - 1
Co-authorsMark Lucock, Martin Veysey
2014Beckett EL, Yates Z, Veysey M, Duesing K, Lucock M, 'The role of vitamins and minerals in modulating the expression of microRNA', Nutrition Research Reviews, 27 94-106 (2014)
DOI10.1017/S0954422414000043
Co-authorsMark Lucock, Martin Veysey
2014Beckett EL, Martin C, Yates Z, Veysey M, Duesing K, Lucock M, 'Bitter taste genetics-the relationship to tasting, liking, consumption and health', Food and Function, 5 3040-3054 (2014) [C1]

Bitter is the most complex of human tastes, and is arguably the most important. Aversion to bitter taste is important for detecting toxic compounds in food; however, many beneficial nutrients also taste bitter and these may therefore also be avoided as a consequence of bitter taste. While many polymorphisms in TAS2R genes may result in phenotypic differences that influence the range and sensitivity of bitter compounds detected, the full extent to which individuals differ in their abilities to detect bitter compounds remains unknown. Simple logic suggests that taste phenotypes influence food preferences, intake and consequently health status. However, it is becoming clear that genetics only plays a partial role in predicting preference, intake and health outcomes, and the complex, pleiotropic relationships involved are yet to be fully elucidated. This journal is

DOI10.1039/c4fo00539b
Co-authorsMark Lucock, Martin Veysey
2014Lucock MD, Martin CE, Yates ZR, Veysey M, 'Diet and Our Genetic Legacy in the Recent Anthropocene: A Darwinian Perspective to Nutritional Health', Journal of Evidence-Based Complementary and Alternative Medicine, 19 68-83 (2014) [C1]

Nutrient-gene research tends to focus on human disease, although such interactions are often a by-product of our evolutionary heritage. This review explores health in this context, reframing genetic variation/epigenetic phenomena linked to diet in the framework of our recent evolutionary past. This "Darwinian/evolutionary medicine" approach examines how diet helped us evolve among primates and to adapt (or fail to adapt) our metabolome to specific environmental conditions leading to major diseases of civilization. This review presents updated evidence from a diet-gene perspective, portraying discord that exists with respect to health and our overall nutritional, cultural, and activity patterns. While Darwinian theory goes beyond nutritional considerations, a significant component within this concept does relate to nutrition and the mismatch between genes, modern diet, obesogenic lifestyle, and health outcomes. The review argues that nutritional sciences should expand knowledge on the evolutionary connection between food and disease, assimilating it into clinical training with greater prominence. © The Author(s) 2013.

DOI10.1177/2156587213503345
CitationsScopus - 3
Co-authorsMark Lucock, Martin Veysey
2014Choi J-H, Yates Z, Veysey M, Heo Y-R, Lucock M, 'Contemporary issues surrounding folic acid fortification initiatives', Preventive Nutrition and Food Science, 19 247-260 (2014) [C1]

The impact of folate on health and disease, particularly pregnancy complications and congenital malformations, has been extensively studied. Mandatory folic acid fortification therefore has been implemented in multiple countries, resulting in a reduction in the occurrence of neural tube defects. However, emerging evidence suggests increased folate intake may also be associated with unexpected adverse effects. This literature review focuses on contemporary issues of concern, and possible underlying mechanisms as well as giving consideration the future direction of mandatory folic acid fortification. Folate fortification has been associated with the presence of unmetabolized folic acid (PteGlu) in blood, masking of vitamin B12 deficiency, increased dosage for anti-cancer medication, photo-catalysis of PteGlu leading to potential genotoxicity, and a role in the pathoaetiology of colorectal cancer. Increased folate intake has also been associated with twin birth and insulin resistance in offspring, and altered epigenetic mechanisms of inheritance. Although limited data exists to elucidate potential mechanisms underlying these issues, elevated blood folate level due to the excess use of PteGlu without consideration of an individual's specific phenotypic traits (e.g. genetic background and undiagnosed disease) may be relevant. Additionally, the accumulation of unmetabolized PteGlu may lead to inhibition of dihydrofolate reductase and other enzymes. Concerns notwithstanding, folic acid fortification has achieved enormous advances in public health. It therefore seems prudent to target and carefully monitor high risk groups, and to conduct well focused further research to better understand and to minimize any risk of mandatory folic acid fortification.

DOI10.3746/pnf.2014.19.4.247
Co-authorsMark Lucock, Martin Veysey
2014Lucock M, Yates Z, Martin C, Choi JH, Boyd L, Tang S, et al., 'Vitamin D, folate, and potential early lifecycle environmental origin of significant adult phenotypes.', Evolution, Medicine, and Public Health, 2014 69-91 (2014) [C1]
DOI10.1093/emph/eou013
Co-authorsPaul Roach, Mark Lucock, John Furst, Martin Veysey
2014Beckett EL, Martin C, Yates Z, Veysey M, Duesing K, Lucock M, 'Bitter taste genetics--the relationship to tasting, liking, consumption and health.', Food Funct, 5 3040-3054 (2014) [C1]
DOI10.1039/c4fo00539bAuthor URL
Co-authorsMark Lucock, Martin Veysey
2014Martin CE, Veysey M, Yates Z, Lucock MD, 'Vitamin D: Genetics, Environment & Health', Food and Nutritional Disorders, 3 1-19 (2014) [C1]
DOI10.4172/2324-9323.1000155
Co-authorsMark Lucock, Martin Veysey
2013Lucock MD, Martin C, Boyd L, Naumovski N, Roach P, Yates Z, Veysey M, 'Response to 'calcium, phosphate and the risk of cardiovascular events and all-cause mortality in a population with stable coronary heart disease'', HEART, 99 349-350 (2013) [C3]
DOI10.1136/heartjnl-2012-302480Author URL
Co-authorsMark Lucock, Paul Roach, Martin Veysey
2013Lucock M, Yates Z, Boyd L, Naylor C, Choi J, Ng X, et al., 'Vitamin C-related nutrient-nutrient and nutrient-gene interactions that modify folate status', European Journal of Nutrition, 52 569-582 (2013) [C1]
DOI10.1007/s00394-012-0359-8Author URL
CitationsScopus - 8Web of Science - 3
Co-authorsMartin Veysey, Paul Roach, Mark Lucock
2013Lucock M, Yates Z, Martin C, Choi J, Boyd L, Tang S, et al., 'Hydrogen sulphide-related thiol metabolism and nutrigenetics in relation to hypertension in an elderly population', Genes & Nutrition, 8 221-229 (2013) [C1]
DOI10.1007/s12263-012-0317-3Author URL
CitationsScopus - 2Web of Science - 1
Co-authorsMartin Veysey, Paul Roach, Mark Lucock
2012Lucock MD, Glanville T, Yates ZR, Walker J, Furst JE, Simpson N, 'Solar cycle predicts folate-sensitive neonatal genotypes at discrete phases of the first trimester of pregnancy: A novel folate-related human embryo loss hypothesis', Medical Hypotheses, 79 210-215 (2012) [C1]
CitationsScopus - 5Web of Science - 4
Co-authorsMark Lucock, John Furst
2011Lucock MD, Ng X, Boyd L, Skinner VM, Wai R, Tang S, et al., 'TAS2R38 bitter taste genetics, dietary vitamin C, and both natural and synthetic dietary folic acid predict folate status, a key micronutrient in the pathoaetiology of adenomatous polyps', Food & Function, 2 457-465 (2011) [C1]
DOI10.1039/c1fo10054h
CitationsScopus - 7Web of Science - 5
Co-authorsMark Lucock, Paul Roach, Martin Veysey
2010Lucock MD, Glanville T, Ovadia L, Yates ZR, Walker J, Simpson N, 'Photoperiod at conception predicts C677T-MTHFR genotype: A novel gene-environment interaction', American Journal of Human Biology, 22 484-489 (2010) [C1]
DOI10.1002/ajhb.21022
CitationsScopus - 11Web of Science - 7
Co-authorsMark Lucock
2010Naumovski N, Veysey M, Ng X, Boyd L, Dufficy L, Blades BL, et al., 'The folic acid endophenotype and depression in an elderly population', Journal of Nutrition, Health and Aging, 14 829-833 (2010) [C1]
DOI10.1007/s12603-010-0135-5
CitationsScopus - 3Web of Science - 2
Co-authorsMaureen Townley-Jones, Mark Lucock, Paul Roach, Martin Veysey
2009Ng X, Boyd L, Dufficy L, Naumovski N, Blades BL, Travers C, et al., 'Folate nutritional genetics and risk for hypertension in an elderly population sample', Journal of Nutrigenetics and Nutrigenomics, 2 1-8 (2009) [C1]
DOI10.1159/000160079
CitationsScopus - 11Web of Science - 9
Co-authorsMark Lucock, Martin Veysey, Maureen Townley-Jones, Paul Roach
2009Yates Z, Tarling E, Langely-Evans S, Salter A, 'Maternal undernutrition programmes atherosclerosis in the APOE3 Leiden mouse', The British Journal of Nutrition: an international journal of nutritional science, 101 1185-1195 (2009) [C1]
DOI10.1017/S0007114508066786
CitationsScopus - 22Web of Science - 18
2009Sohn K-J, Jang H, Campan M, Weisenberger DJ, Dickhout J, Wang Y-C, et al., 'The methylenetetrahydrofolate reductase C677T mutation induces cell-specific changes in genomic DNA methylation and uracil misincorporation: A possible molecular basis for the site-specific cancer risk modification', International Journal of Cancer, 124 1999-2005 (2009) [C1]
DOI10.1002/ijc.24003
CitationsScopus - 42Web of Science - 42
Co-authorsMark Lucock
2009Lucock MD, Yates ZR, 'Folic acid fortification: A double-edged sword', Current Opinion in Clinical Nutrition & Metabolic Care, 12 555-564 (2009) [C1]
DOI10.1097/mco.0b013e32833192bc
CitationsScopus - 39Web of Science - 31
Co-authorsMark Lucock
2008Palep-Singh M, Picton HM, Yates ZR, Barth J, Balen AH, 'Plasma homocysteine concentrations and the single nucleotide polymorphism in the methionine synthase gene (MTR 2756A>G): Associations with the polycystic ovary syndrome An observational study', European Journal of Obstetrics Gynecology and Reproductive Biology, 138 180-186 (2008) [C1]
DOI10.1016/j.ejogrb.2007.12.015
CitationsScopus - 9Web of Science - 7
2007Palep-Singh M, Picton H, Yates Z, Barth J, Balen A, 'Polycystic ovary syndrome and the single nucleotide polymorphisms of methylenetetrahydrofolate reductase: a pilot observational study.', Human Fertility: an international multidisciplinary journal dedicated to furthering research and promoting good practice, 10 33-41 (2007) [C1]
DOI10.1080/14647270600950157
2007Lucock MD, Yates ZR, Ng X, Veysey MJ, Blades BL, Travers C, et al., 'Preliminary evidence for genetic selection of 677T-MTHFR by natural annual cycle of folate abundance', Journal of Nutrigenetics and Nutrigenomics, 1 24-29 (2007) [C1]
DOI10.1159/000109872
CitationsScopus - 10Web of Science - 8
Co-authorsPaul Roach, Martin Veysey, Mark Lucock
2006Dufficy L, Naumovski N, Ng X, Blades BL, Yates ZR, Travers C, et al., 'G80A reduced folate carrier SNP influences the absorption and cellular translocation of dietary folate and its association with blood pressure in an elderly population', Life Sciences, 79 957-966 (2006) [C1]
DOI10.1016/j.lfs.2006.05.009
CitationsScopus - 19Web of Science - 19
Co-authorsMartin Veysey, Paul Roach, Mark Lucock
2006Glanville T, Yates ZR, Ovadia L, Walker JJ, Lucock MD, Simpson NAB, 'Fetal folate C677T methylenetetrahydrofolate reductase gene polymorphism and low birth weight', Journal of Obstetrics and Gynaecology, 26 11-14 (2006) [C1]
DOI10.1080/01443610500363865
CitationsScopus - 10
Co-authorsMark Lucock
2006Lucock MD, Yates ZR, 'Synergy between 677 TT MTHFR genotype and related folate SNPs regulates homocysteine level', Nutrition Research, 26 180-185 (2006) [C1]
DOI10.1016/j.nutres.2006.01.001
CitationsScopus - 6Web of Science - 6
Co-authorsMark Lucock
2005Lucock MD, Ng X, Veysey MJ, Yates ZR, 'Folic acid: An essential nutrient with added health benefits', Biologist, 52 21-27 (2005) [C1]
CitationsScopus - 2
Co-authorsMark Lucock, Martin Veysey
2005Yates ZR, Lucock MD, 'G80A reduced folate carrier SNP modulates cellular uptake of folate and affords protection against thrombosis via a non homocysteine related mechanism', Life Sciences, 77 2735-2742 (2005) [C1]
DOI10.1016/j.lfs.2005.02.029
CitationsScopus - 31Web of Science - 31
Co-authorsMark Lucock
2005Lucock MD, Yates ZR, 'Human genetic selection by folates', Nature Reviews Genetics, 6 online (2005) [C3]
Co-authorsMark Lucock
2004Sohn K-J, Smirnakis F, Moskovitz DN, Novakovic P, Yates ZR, Lucock MD, et al., 'Effects of folylpolyglutamate synthetase modulation on chemosensitivity of colon cancer cells to 5-fluorouracil and methotrexate', GUT, 53 1825-1831 (2004) [C1]
DOI10.1136/gut.2004.042713
CitationsScopus - 18Web of Science - 17
Co-authorsMark Lucock
2004Sohn K-J, Croxford R, Yates ZR, Lucock MD, Kim Y-I, 'Effect of the methylenetetrahydrofolate reductase C677T polymorphism on chemosensitivity of colon and breast cancer cells to 5-fluorouracil and methotrexate', Journal of the National Cancer Institute, 96 134-144 (2004) [C1]
DOI10.1093/jnci/djh
CitationsScopus - 155Web of Science - 148
Co-authorsMark Lucock
2003Lucock MD, Yates ZR, Glanville T, Leeming R, Simpson N, Daskalakis I, 'A critical role for B-vitamin nutrition in human developmental and evolutionary biology', Nutrition Research, 23 1463-1475 (2003) [C1]
DOI10.1016/S0271-5317(03)00156-8
CitationsScopus - 40Web of Science - 26
Co-authorsMark Lucock
2003Fenton J, Pratt G, Rawstron A, Sibley K, Rothwell D, Yates Z, et al., 'Genomic characterisation of the chromosomal breakpoints of t(4; 14) of multiple myeloma suggests more than one possible aetiological mechanism', Oncogene, 22 1103-1113 (2003) [C1]
DOI10.1038/sj.onc.1206335
2003Yates Z, Lucock M, 'Interaction between common folate polymorphisms and B-vitamin nutritional status modulates homocysteine and risk for a thrombotic event', MOLECULAR GENETICS AND METABOLISM, 79 201-213 (2003) [C1]
DOI10.1016/S1096-7192(03)00093-3Author URL
CitationsScopus - 16Web of Science - 15
Co-authorsMark Lucock
2002Lucock M, Yates Z, 'Measurement of red blood cell methylfolate', LANCET, 360 1021-1022 (2002) [C1]
DOI10.1016/S0140-6736(02)11105-6Author URL
CitationsScopus - 8Web of Science - 5
Co-authorsMark Lucock
2002Yates Z, Lucock M, 'Methionine synthase, polymorphism A2756G is associated with susceptibility for thromboembolic events and altered B vitamin/thiol metabolism', HAEMATOLOGICA, 87 751-756 (2002) [C1]
Author URL
CitationsScopus - 18Web of Science - 18
Co-authorsMark Lucock
2002Lucock M, Yates Z, Hall K, Leeming R, Rylance G, MacDonald A, Green A, 'The impact of phenylketonuria on folate metabolism', MOLECULAR GENETICS AND METABOLISM, 76 305-312 (2002) [C1]
DOI10.1016/S1096-7192(02)00113-0Author URL
CitationsScopus - 12Web of Science - 10
Co-authorsMark Lucock
2001Lucock M, Daskalakis I, Yates Z, 'C677T MTHFR genotypes show graded response to vitamin B-12 dependent regeneration of tetrahydrofolate, the main congener of all cellular folates', NUTRITION RESEARCH, 21 1357-1362 (2001) [C1]
DOI10.1016/S0271-5317(01)00345-1Author URL
CitationsScopus - 2Web of Science - 1
Co-authorsMark Lucock
2001Lucock M, Daskalakis I, Hinkins M, Yates Z, 'An examination of polymorphic genes and folate metabolism in mothers affected by a spina bifida pregnancy', MOLECULAR GENETICS AND METABOLISM, 73 322-332 (2001) [C1]
DOI10.1006/mgme.2001.3205Author URL
CitationsScopus - 26Web of Science - 25
Co-authorsMark Lucock
2001Lucock M, Yates Z, 'Update on folic acid and neural tube defects: 'Comment' article', Clinical Nutrition, 10 25-33 (2001) [C1]
2000Lucock M, Daskalakis I, Briggs D, Yates Z, Levene M, 'Altered folate metabolism and disposition in mothers affected by a spina bifida pregnancy: Influence of 677c -> t methylenetetrahydrofolate reductase and 2756a -> g methionine synthase genotypes', MOLECULAR GENETICS AND METABOLISM, 70 27-44 (2000) [C1]
DOI10.1006/mgme.2000.2994Author URL
CitationsScopus - 36Web of Science - 36
Co-authorsMark Lucock
1999Pratt G, Fenton J, Proffitt J, Yates Z, Davies F, Rawstron A, et al., 'Molecular characterisation of chromosome 14q32 translocations in patients with multiple myeloma.', Blood 94, 2435., (1999) [C1]
1999Fenton J, Proffitt J, Pratt G, Rawstron A, Yates Z, Davies F, et al., 'Identification of a novel translocation t(14;22)(q32;q12) in multiple myeloma.', British Journal of Cancer, (1999) [C1]
1999Pratt G, Fenton J, Proffitt J, Yates Z, Davies F, Rawstron A, et al., 'Rawstron A., Child J., Morgan G. (1999) A novel translocation t(14;22)(q32;q12) in multiple myeloma.', British Journal of Haematology, (1999) [C1]
1999Cunningham J, Yates Z, Hamilton J, Mason G, Muller R, Miller D, 'Non-invasive RNA-based determination of fetal Rhesus D type: a prospective study based on 96 pregnancies.', British Journal of Obstetrics and Gynaecology, 1023-1028 (1999) [C1]
1999Proffitt J, Fenton J, Pratt G, Yates Z, Morgan G, 'Isolation and characterisation of recombination events involving immunoglobulin heavy chain switch regions in multiple myeloma using long distance vectorette PCR (LDV-PCR)', Leukemia, 1100-1107 (1999) [C1]
1998Pratt G, Fenton J, Proffitt J, Yates Z, Davies F, Rawstron A, et al., 'Rapid characterisation of switch recombination events from patients with multiple myeloma and the characterisation of a novel translocation t(14;22)(q32;q12): Implications for the process of switch recombination and the pathogenesis of myeloma.', Blood 92, 278., (1998) [C1]
Show 48 more journal articles

Conference (18 outputs)

YearCitationAltmetricsLink
2014Veysey M, Siow W, Niblett S, King K, Yates Z, Lucock M, 'Hepatic fibrosis in an elderly population', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2014) [E3]
Author URL
Co-authorsMark Lucock, Martin Veysey, Katrina King
2014Veysey M, Siow W, Niblett S, King K, Yates Z, Lucock M, 'White cell counts and non-alcoholic fatty liver disease', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2014) [E3]
Author URL
Co-authorsMartin Veysey, Mark Lucock
2013Veysey M, Siow W, Choi J-H, Martin C, Tang S, Yates ZR, Lucock M, 'A Bitter Taste Gene (P49a Variant of Tas2r38) Interacts With A1298c-MTHFR to Modify Risk for Adenomas in an Australian Population', GASTROENTEROLOGY, Orlando, FL (2013) [E3]
Author URL
Co-authorsMartin Veysey, Mark Lucock
2013Choi J, Siow W, Yates Z, Lucock M, Veysey M, 'Influence of synthetic folic acid concentration on Caco-2 cell growth', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2013) [E3]
Author URL
Co-authorsMark Lucock, Martin Veysey
2013Siow W, Niblett S, King K, Yates Z, Hampe T, Lucock M, Veysey M, 'Prevalence of non-alcoholic fatty liver disease in an elderly Australian population', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2013) [E3]
Author URL
Co-authorsKatrina King, Martin Veysey, Mark Lucock
2013Siow W, Niblett S, King K, Yates Z, Martin C, Lucock M, Veysey M, 'A community-based study of dietary macro and micronutrients and the risk of colorectal cancer in an elderly Australian population', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2013) [E3]
Author URL
Co-authorsMark Lucock, Katrina King, Martin Veysey
2011Choi J-H, Yates ZR, Boyd L, Veysey MJ, Lucock MD, 'Dietary folate vitamers as potential risk factors in the aetiology of adenomatous polyps', Australasian Medical Journal, Queenstown, NZ (2011) [E3]
Co-authorsMark Lucock, Martin Veysey
2011Yates ZR, Kho J, Choi J-H, Boyd L, Ng X, Skinner V, et al., 'C776G TCNII genotype influences the relationship between blood vitamin B12 and cellular folate', Australasian Medical Journal, Queenstown, NZ (2011) [E3]
Co-authorsMark Lucock, Martin Veysey
2011Naylor C, Lucock MD, Veysey MJ, Naumovski N, Boyd L, Dufficy L, et al., 'Folate nutritional genetics and degenerative disorders in the elderly with special reference to hypertension and depression', Australasian Medical Journal, Queenstown, NZ (2011) [E3]
Co-authorsPaul Roach, Martin Veysey, Mark Lucock
2010Chang J, Lucock MD, Wai R, Boyd L, Ng X, Skinner VM, et al., 'Dietary folic acid, red cell folate and the risk of adenomatous polyps in an Australian population', Journal of Gastroenterology and Hepatology. Special Issue: Australian Gastroenterology Week 2010, Gold Coast, QLD (2010) [E3]
Co-authorsMartin Veysey, Mark Lucock, Paul Roach
2009Veysey MJ, Boyd L, Wai R, Ng X, Skinner V, Tang S, et al., 'Preliminary data to support a relationship between taste genetics, folate status, folate genes and the development of colonic adenomas: A novel nutrigenomic circuit', Gastro 2009 UEGW/WCOG: Scientific Programme & EACCME, London, UK (2009) [E3]
Co-authorsMartin Veysey, Paul Roach, Mark Lucock
2009Boyd L, Lucock MD, Wai R, Ng X, Yates ZR, Skinner V, et al., 'Folate status: A recognised determinant of colorectal neoplasia may be modified by bitter taste perception and genetics', Proceedings of the Nutrition Society of Australia, Newcastle, NSW (2009) [E3]
Co-authorsPaul Roach, Martin Veysey, Mark Lucock
2008Yates ZR, Lucock MD, 'Folate and the C677T-MTHFR variant: Impact on population health', Journal of Nutrigenetics and Nutrigenomics, Melbourne, VIC (2008) [E3]
DOI10.1159/000128589
Co-authorsMark Lucock
2008Ng X, Boyd L, Dufficy L, Naumovski N, Blades BL, Travers C, et al., 'Folate genes and risk for hypertension in an elderly population sample', 3rd Asia Pacific Nutrigenomics Conference: Conference Program & Information, Melbourne, VIC (2008) [E3]
Co-authorsMark Lucock, Martin Veysey, Paul Roach
2008Wai RKH, Boyd L, Ng X, King K, Skinner V, Roach PD, et al., 'Preliminary evidence that bitter taste perception can modify folate status: A recognised risk factor for colorectal neoplasia', Journal of Gastroenterology and Hepatology, Brisbane, QLD (2008) [E3]
Co-authorsMark Lucock, Paul Roach, Martin Veysey
2008Boyd L, Wai RKH, Ng X, King K, Skinner V, Roach PD, et al., 'A preliminary study to examine whether common folate polymorphisms are risk factors for the development of adenomatous polyps', Journal of Gastroenterology and Hepatology, Brisbane, QLD (2008) [E3]
Co-authorsMark Lucock, Paul Roach, Martin Veysey
2004Novakovic P, Sohn KJ, Chiang EP, Dickhout J, Yates Z, Lucock M, et al., 'Effect of MTHFR C677T polymorphism on the intracellular methionine cycle and DNA methylation in colon cancer cells', FASEB JOURNAL, Washington, DC (2004)
Author URL
Co-authorsMark Lucock
2004Moskovitz DN, Sohn KJ, Smirnakis F, Novakovic P, Yates ZR, Lucock MD, et al., 'Effects of folylpolyglutamyl synthetase modulation on chemosensitivity of colon cancer cells to 5 fluorouracil and methotrexate', CDDW Abstracts, Canada (2004) [E3]
Co-authorsMark Lucock
Show 15 more conferences
Edit

Grants and Funding

Summary

Number of grants6
Total funding$686,150

Click on a grant title below to expand the full details for that specific grant.


20121 grants / $24,500

Phase I and II detoxification genes; the correlation of epigenetic modifications with nutritional status, lifestyle factors, health and disease$24,500

Funding body: CSIRO - Energy Technology

Funding bodyCSIRO - Energy Technology
Project TeamAssociate Professor Mark Lucock, Associate Professor Martin Veysey, Doctor Zoe Yates, Miss Emma Beckett, Dr Konsta Duesing
SchemePostgraduate Research Scholarship
RoleInvestigator
Funding Start2012
Funding Finish2012
GNoG1200845
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

20092 grants / $91,281

The Association between Folate Nutritional Status and Folate Gene Polymorphisms in an Elderly Australian Population$61,281

Funding body: Central Coast Local Health District

Funding bodyCentral Coast Local Health District
Project TeamAssociate Professor Martin Veysey, Doctor Zoe Yates, Associate Professor Mark Lucock, Doctor Paul Roach
SchemeResearch Sponsorship Scholarship
RoleInvestigator
Funding Start2009
Funding Finish2009
GNoG0190658
Type Of FundingOther Public Sector - State
Category2OPS
UONY

Development of a model to study the B-vitamin related nutritional genetics of human aging$30,000

Funding body: Ramaciotti Foundations

Funding bodyRamaciotti Foundations
Project TeamDoctor Zoe Yates
SchemeEstablishment Grant
RoleLead
Funding Start2009
Funding Finish2009
GNoG0189324
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

20073 grants / $570,369

2007 Research Fellowship$550,618

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Zoe Yates
SchemeResearch Fellowship
RoleLead
Funding Start2007
Funding Finish2007
GNoG0187072
Type Of FundingInternal
CategoryINTE
UONY

2007 Research Fellowship Project grant$15,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Zoe Yates
SchemeFellowship Grant
RoleLead
Funding Start2007
Funding Finish2007
GNoG0188077
Type Of FundingInternal
CategoryINTE
UONY

Bitter taste phenotype, dietary pattern and nutritional genetics in the aetiopathology of human colonic adenoma/cancer$4,751

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Zoe Yates
SchemePilot Grant
RoleLead
Funding Start2007
Funding Finish2007
GNoG0187909
Type Of FundingInternal
CategoryINTE
UONY
Edit

Research Supervision

Current Supervision

CommencedResearch Title / Program / Supervisor Type
2012The Association of MIRNA Profiles and DNA Methylation with Micronutrient Intake & Status
Food Science & Biotechnology, Faculty of Science and Information Technology
Co-Supervisor
2010Genotype-Phenotype Relationships Relevant to the Lifecycle with Special Reference to Vitamin Nutrition
Food Science & Biotechnology, Faculty of Science and Information Technology
Principal Supervisor

Past Supervision

YearResearch Title / Program / Supervisor Type
2014In Vitro and In Vivo Approaches to the Examination of Folate-Related Nutritional Genetics in Health and Disease
Food Science & Biotechnology, Faculty of Science and Information Technology
Principal Supervisor
Edit

News

The Conversation

Superfoods: not so super after all?

June 16, 2013

By Emma Beckett and Zoe Yates, University of Newcastle

Superfoods is a buzzword now part of mainstream food and health language, often touted as miracle foods that cure all ills, stave off ageing and disease, or aid weight loss.

Dr Zoe Yates

Position

Lecturer
Human Molecular Nutrition
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

Focus area

Applied Sciences

Contact Details

Emailzoe.yates@newcastle.edu.au
Phone(02) 4349 4560
Fax(02) 4348 4145

Office

RoomBE 137
BuildingHealth Precinct
LocationOurimbah
10 Chittaway Road
Ourimbah, NSW 2258
Australia
Edit