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Dr Susan Hua

Senior Lecturer

School of Biomedical Sciences and Pharmacy (Pharmacy and Experimental Pharmacology)

Career Summary


Keywords

  • Acute and chronic pain
  • Arthritis
  • Inflammation
  • Nano-delivery systems
  • Nanomedicines
  • Opioids
  • Peripheral analgesia
  • Pharmaceutical dosage form design
  • Pharmacotherapeutics
  • Pharmacy Practice
  • Targeted drug delivery

Fields of Research

CodeDescriptionPercentage
100709Nanomedicine30
110322Rheumatology and Arthritis50
111504Pharmaceutical Sciences20

Professional Experience

UON Appointment

DatesTitleOrganisation / Department
1/01/2015 - Senior LecturerUniversity of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Book (1 outputs)

YearCitationAltmetricsLink
2015Hua SH, Cabot PC, PAIN - Novel Targets and New Technologies, Frontiers in Pharmacology, Switzerland, 95 (2015)

Journal article (19 outputs)

YearCitationAltmetricsLink
2015Paul J, Hua S, Smith R, 'A Targeted Drug Delivery System for the Uterus', REPRODUCTIVE SCIENCES, 22 57A-57A (2015)
Author URL
2015Hua S, Marks E, Schneider JJ, Keely S, 'Advances in oral nano-delivery systems for colon targeted drug delivery in inflammatory bowel disease: Selective targeting to diseased versus healthy tissue.', Nanomedicine, 11 1117-1132 (2015)
DOI10.1016/j.nano.2015.02.018Author URL
Co-authorsJennifer Schneider
2014Jobling P, O'Hara K, Hua S, 'Female reproductive tract pain: Targets, challenges, and outcomes', Frontiers in Pharmacology, 5 FEB (2014) [C1]

Pain from the female reproductive tract (FRT) is a significant clinical problem for which there are few effective therapies. The complex neuroanatomy of pelvic organs not only makes diagnosis of pelvic pain disorders difficult but represents a challenge to development of targeted therapies. A number of potential therapeutic targets have been identified on sensory neurons supplying the FRT but our knowledge on the basic neurophysiology of these neurons is limited compared with other viscera. Until this is addressed we can only guess if the new experimental therapies proposed for somatic, gastrointestinal, or bladder pain will translate to the FRT. Once suitable therapeutic targets become clear, the next challenge is drug delivery. The FRT represents a promising system for topical drug delivery that could be tailored to act locally or systemically depending on formulation. Development of these therapies and their delivery systems will need to be done in concert with more robust in vivo and in vitro models of FRT pain. © 2014 Jobling, O'Hara and Hua.

DOI10.3389/fphar.2014.00017
CitationsScopus - 1Web of Science - 1
Co-authorsPhillip Jobling
2014Hua S, 'Comparison of in vitro dialysis release methods of loperamide-encapsulated liposomal gel for topical drug delivery', International Journal of Nanomedicine, 9 735-744 (2014) [C1]

Background: The purpose of this study was to determine the most appropriate dialysis equilibrium method to assess liposomal gel formulations containing hydrophobic drugs, to give the most accurate indication of drug release. Methods: Loperamide hydrochloride-encapsulated liposomes, composed of L-a-phosphatidylcholine and cholesterol (molar ratio of 2:1), were prepared according to the method of dried lipid film hydration. The liposomes were incorporated into a carbopol gel (0.5%, weight/weight). The release of the drug from the nanoparticles was assessed using a number of variations of the dialysis technique, taking into account solubility parameters and formulation. Method 1 (below saturation point) and Method 2 (above saturation point) used a dilution method to evaluate how drug concentration and solubility affects the in vitro drug-release profile of loperamide hydrochloride, while Methods 3 (below saturation point) and 4 (above saturation point) evaluated how drug concentration and the gel base affect the release profile. Results: In Method 1, the liposomes showed a rapid release of just over 60% in the first 3 hours and then a slower, sustained release to just over 70% at 24 hours. Method 2 showed a gradual, sustained release profile with the liposomes with 55% release at 24 hours. In Method 3, the liposomes showed a rapid burst release of 98% at 2 hours. In Method 4, the liposomal gel had a rapid release of 60% within 3 hours and then a more gradual, sustained release with 86% release at 24 hours. The free drug suspension in Methods 2 and 4 showed a limited release across the dialysis membrane, in comparison to Methods 1 and 3, which showed a complete release in a timely manner. Conclusion: This study has demonstrated that the actual method used for equilibrium dialysis plays a significant role in determining the true characteristics of a topical nanoformulation, with Method 3 providing the most accurate indication of the release of a hydrophobic drug from a topical liposomal formulation. © 2014 Hua.

DOI10.2147/IJN.S55805
CitationsScopus - 2Web of Science - 1
2014Iwaszkiewicz KS, Hua S, 'Development of an effective topical liposomal formulation for localized analgesia and antiinflammatory actions in the Complete Freund¿s Adjuvant rodent model of acute inflammatory pain', Pain Physician, 17 E719-E735 (2014) [C1]
2014Jobling P, O'Hara K, Hua S, 'Female reproductive tract pain: targets, challenges, and outcomes.', Front Pharmacol, 5 17 (2014) [C1]
DOI10.3389/fphar.2014.00017Author URL
CitationsScopus - 1Web of Science - 1
Co-authorsPhillip Jobling
2014Hua S, Cabot PJ, 'PAIN - Novel targets and new technologies', Frontiers in Pharmacology, 5 (2014) [C3]
DOI10.3389/fphar.2014.00211
2014Hua S, 'Orally administered liposomal formulations for colon targeted drug delivery', Frontiers in Pharmacology, 5 JUN 1-4 (2014) [C2]
DOI10.3389/fphar.2014.00138
CitationsScopus - 1
2013Hua S, 'Targeting sites of inflammation: intercellular adhesion molecule-1 as a target for novel inflammatory therapies.', Front Pharmacol, 4 127 (2013) [C1]
DOI10.3389/fphar.2013.00127Author URL
CitationsScopus - 12Web of Science - 10
2013Iwaszkiewicz KS, Schneider JJ, Hua S, 'Targeting peripheral opioid receptors to promote analgesic and anti-inflammatory actions.', Front Pharmacol, 4 132 (2013) [C1]
DOI10.3389/fphar.2013.00132Author URL
CitationsWeb of Science - 8
Co-authorsJennifer Schneider
2013Hua S, Wu SY, 'The use of lipid-based nanocarriers for targeted pain therapies', Frontiers in Pharmacology, 4 NOV (2013) [C1]
DOI10.3389/fphar.2013.00143
CitationsScopus - 7Web of Science - 7
2013Iwaszkiewicz KS, Schneider JJ, Hua S, 'Targeting peripheral opioid receptors to promote analgesic and anti-inflammatory actions', FRONTIERS IN PHARMACOLOGY, 4 (2013) [C1]
DOI10.3389/fphar.2013.00132Author URL
CitationsWeb of Science - 6
Co-authorsJennifer Schneider
2013Hua S, Cabot PJ, 'Targeted Nanoparticles that Mimic Immune Cells in Pain Control Inducing Analgesic and Anti-inflammatory Actions: A Potential Novel Treatment of Acute and Chronic Pain Conditions', PAIN PHYSICIAN, 16 E199-E216 (2013) [C1]
Author URL
CitationsScopus - 11Web of Science - 12
2011Witting PK, Song C, Hsu K, Hua S, Parry SN, Rye K, et al., 'The acute phase protein serum amyloid A induces endothelial dysfunction that is inhibited by high-density lipoprotein.', Free Radical Biology and Medicine, 51 1390-1398 (2011) [C1]
CitationsScopus - 16Web of Science - 15
2011Hua S, Chang H-I, Davies N, Cabot PJ, 'Targeting of ICAM-1-directed immunoliposomes specifically to activated endothelial cells with low cellular uptake: use of an optimized procedure for the coupling of low concentrations of antibody to liposomes.', Journal of Liposome Research, 21 95-105 (2011) [C1]
CitationsScopus - 7Web of Science - 6
2010Hua S, Cabot PJ, 'Mechanisms of peripheral immune-cell-mediated analgesia in inflammation: Clinical and therapeutic implications', Trends in Pharmacological Sciences, 31 427-433 (2010) [C1]
DOI10.1016/j.tips.2010.05.008
CitationsScopus - 24Web of Science - 23
2009Rayner BS, Hua S, Sabaretnam T, Witting PK, 'Nitric oxide stimulates myoglobin gene and protein expression in vascular smooth muscle.', Biochemical Journal, 423 169-177 (2009) [C1]
CitationsScopus - 12Web of Science - 11
2009Hua S, Geczy CL, Freedman SB, Witting PK, 'A role for acute-phase serum amyloid A and high-density lipoprotein in oxidative stress, endothelial dysfunction and atherosclerosis.', Redox Report, 14 187-196 (2009) [C1]
CitationsScopus - 23Web of Science - 19
2006Hua S, Hermanussen S, Tang L, Monteith GR, Cabot PJ, 'The neural cell adhesion molecule antibody blocks cold water swim stress-induced analgesia and cell adhesion between lymphocytes and cultured dorsal root ganglion neurons', Anesthesia and Analgesia, 103 1558-1564 (2006) [C1]
DOI10.1213/01.ane.0000243410.61451.c1
CitationsScopus - 18Web of Science - 18
Show 16 more journal articles

Conference (4 outputs)

YearCitationAltmetricsLink
2015Nguyen TS, Nguyen TLH, Hua S, Li SC, 'Enhancing the role of hospital pharmacists in a developing country - the current scenario in Vietnam', ACCP, Bangkok, Thailand (2015)
2014Hua S, 'The use of lipid-based nanocarriers for targeting sites of inflammation', 4th Annual Symposium of Drug Delivery Systems, Suzhou, China (2014) [E3]
2014Hua SH, 'Targeting peripheral opioid receptors to induce analgesic and anti-inflammatory actions', 5th Annual International Congress of Medichem, Suzhou, China (2014) [E3]
2012Hua S, Cabot PJ, 'Loperamide-formulated immunoliposomes directed towards intercellular adhesion molecule-1 (ICAM-1): A potential tool for specific drug delivery to peripheral inflammatory pain', Abstracts of the 39th Annual Meeting and Exposition of the Controlled Release Society, Quebec, ON (2012) [E3]
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Grants and Funding

Summary

Number of grants9
Total funding$687,037

Click on a grant title below to expand the full details for that specific grant.


20142 grants / $27,000

Achieving Targeted Delivery of Drugs to Uterine Muscle in Women for the Prevention of Preterm Labour$25,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Jonathan Paul, Doctor Susan Hua, Professor Roger Smith
SchemeProject Grant
RoleInvestigator
Funding Start2014
Funding Finish2014
GNoG1401504
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

The 4th Annual Symposium of drug Delivery System 2014 (SDDS-2014), Suzhou China, 17 - 20 November 2014$2,000

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding bodyUniversity of Newcastle - Faculty of Health and Medicine
Project TeamDoctor Susan Hua
SchemeTravel Grant
RoleLead
Funding Start2014
Funding Finish2014
GNoG1400807
Type Of FundingInternal
CategoryINTE
UONY

20132 grants / $612,956

Understanding the regulation of hERG potassium channel in the myometrium at the time of labour$577,956

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Roger Smith, Professor Nick Europe-Finner, Doctor Susan Hua
SchemeProject Grant
RoleInvestigator
Funding Start2013
Funding Finish2013
GNoG1200367
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

20122 grants / $21,500

Peripheral immune-derived analgesia: A new target for the treatment of rheumatoid arthritis$20,000

Funding body: Pharmacy Research Trust of NSW

Funding bodyPharmacy Research Trust of NSW
Project TeamDoctor Susan Hua
SchemeResearch Grant
RoleLead
Funding Start2012
Funding Finish2012
GNoG1101131
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

The 39th Annual Meeting and Exposition of the Controlled Release Society, Quebec City, Canada, 15 - 18 July 2012$1,500

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding bodyUniversity of Newcastle - Faculty of Health and Medicine
Project TeamDoctor Susan Hua
SchemeTravel Grant
RoleLead
Funding Start2012
Funding Finish2012
GNoG1200581
Type Of FundingInternal
CategoryINTE
UONY

20111 grants / $15,581

Development of novel targeted drug delivery systems specifically to sites of inflammation and its application to peripheral analgesia and inflammation in chronic arthritic pathologies$15,581

Funding body: Rebecca L Cooper Medical Research Foundation Ltd

Funding bodyRebecca L Cooper Medical Research Foundation Ltd
Project TeamDoctor Susan Hua
SchemeResearch Grant
RoleLead
Funding Start2011
Funding Finish2011
GNoG1000741
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

20102 grants / $10,000

Development of Novel Targeted Drug Delivery Systems to Sites of Inflammation$7,395

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Susan Hua
SchemeEarly Career Researcher Grant
RoleLead
Funding Start2010
Funding Finish2010
GNoG1000970
Type Of FundingInternal
CategoryINTE
UONY

Development of Novel Targeted Drug Delivery Systems to Sites of Inflammation$2,605

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Susan Hua
SchemeEarly Career Researcher (Equipment) Grant
RoleLead
Funding Start2010
Funding Finish2010
GNoG1000683
Type Of FundingInternal
CategoryINTE
UONY
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Research Supervision

Current Supervision

CommencedResearch Title / Program / Supervisor Type
2014Improvement of Quality Use of Medicine in Chronic Respiratory Diseases
Pharmacy, Faculty of Health and Medicine
Co-Supervisor
2014Peripheral Opioid Receptor Targeting for the Relief of Pain, Inflammation and Disease Progression in Rheumatoid Arthritis
Pharmacy, Faculty of Health and Medicine
Principal Supervisor
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Dr Susan Hua

Position

Senior Lecturer
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

Focus area

Pharmacy and Experimental Pharmacology

Contact Details

Emailsusan.hua@newcastle.edu.au
Phone(02) 49854063
Fax(02) 49217903

Office

RoomMS126
BuildingMedical Science Building
LocationCallaghan
University Drive
Callaghan, NSW 2308
Australia
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