Staff Profile

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Career Summary

Biography

I completed my PhD studies with Dr Kelly McNagny at The Biomedical Research Centre, University of British Columbia in Vancouver, BC, Canada. My research focused on the role of CD34 (and the related molecule podocalyxin) in immune responses, using mouse models of disease. Those studies identified the importance of CD34 for efficient eosinophil and mast cell migration to sites of inflammation during disease. Further, I demonstrated that loss of CD34 expression (using transgenic Cd34-/- animals) resulted in reduced disease severity in mouse models of asthma and ulcerative colitis.

My current research focus is aimed at characterizing changes in the bone marrow during disease and infection. The aim of these studies is to identify key molecules involved in feedback from sites of infection/inflammation to the bone marrow and alterations to hematopoietic stem and progenitor cells.

Qualifications

  • PhD, University of British Columbia - Canada, 17/11/2010
  • Bachelor of Science, University of British Columbia - Canada, 19/05/2004

Research

Research keywords

  • Asthma
  • Disease Models
  • Eosinophils
  • Hematopoiesis
  • Immunology

Research expertise

Main Research Focus Areas:

Bone Marrow Responses to Infection and Disease

MicroRNA

Immune Cell Activation and Migration

Eosinophil Regulation

Languages

  • English

Fields of Research

CodeDescriptionPercentage
110700Immunology50
110309Infectious Diseases30
110316Pathology20

Awards

Research Award.

2012Postdoctoral Research Fellowship
Canadian Institute of Health Research (CIHR) (Canada)
Canadian national research fellowship
2012Postdoctoral Research Fellowship
University of Newcastle (Australia)
University of Newcastle research fellowship

Teaching

Teaching keywords

  • Immunology

Teaching expertise

Immunology

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Highlighted Publications

For publications that are currently unpublished or in-press, details are shown in italics.

YearCitationAltmetricsLink
2011Maltby SJ, Freeman S, Gold MJ, Baker JH, Minchinton AI, Gold MR, et al., 'Opposing Roles for CD34 in B16 Melanoma Tumor Growth Alter Early Stage Vasculature and Late Stage Immune Cell Infiltration', PLoS One, 6 (2011) [C1]
2010Maltby SJ, Wohlfarth C, Gold M, Zbytnuik L, Hughes MR, McNagny KM, 'CD34 is required for infiltration of eosinophils into the colon and pathology associated with DSS-induced ulcerative colitis', American Journal of Pathology, 177 1244-1254 (2010) [C1]
2009Maltby SJ, Hughes MR, Zbytnuik L, Paulson RF, McNagny KM, 'Podocalyxin selectively marks erythroid-committed progenitors during anemic stress but is dispensable for efficient recovery', Experimental Hematology, 37 10-18 (2009) [C1]
2009Maltby SJ, Khash K, McNagny KM, 'Mast cells in tumor growth: angiogenesis, tissue remodeling and immune-modulation', Biochimica et biophysica acta - Reviews on Cancer (2009) [D1]
2007Blanchet M-R, Maltby SJ, Haddon DJ, Merkens H, Zbytnuik L, McNagny KM, 'CD34 facilitates the development of allergic asthma', Blood, 110 2005-2012 (2007) [C1]

Publications

For publications that are currently unpublished or in-press, details are shown in italics.

Click on a category title below to expand the list of citations for that specific category.

Chapter (1 outputs)

YearCitationAltmetricsLink
2013Maltby S, McNagny KM, Ackerman SJ, Du J, Mori Y, Iwasaki H, et al., 'Eosinophilopoiesis', Eosinophils in Health and Disease, Elsevier Inc. 73-119 (2013) [B2]

Journal article (11 outputs)

YearCitationAltmetricsLink
2014Maltby S, Hansbro NG, Tay HL, Stewart J, Plank M, Donges B, et al., 'Production and differentiation of myeloid cells driven by proinflammatory cytokines in response to acute pneumovirus infection in mice.', J Immunol, 193 4072-4082 (2014)
2014Mateer S, Maltby S, Marks E, Goggins B, Horvat J, Hansbro P, Keely S, 'Immune cell mis-homing drives secondary organ inflammation in inflammatory bowel disease; a focus on the respiratory system', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 29 19-20 (2014)
2013Plank M, Maltby S, Mattes J, Foster PS, 'Targeting translational control as a novel way to treat inflammatory disease: the emerging role of microRNAs.', Clinical and Experimental Allergy, 43 981-999 (2013) [C1]
2013Plank M, Maltby S, Mattes J, Foster PS, 'Targeting translational control as a novel way to treat inflammatory disease: The emerging role of MicroRNAs', Clinical and Experimental Allergy, 43 981-999 (2013) [C1]
2012Maltby SJ, Debruin EJ, Bennett J, Gold MJ, Tunis MC, Jian Z, et al., 'IL-7Ra and L-selectin, but not CD103 or CD34, are required for murine peanut-induced anaphylaxis', Allergy Asthma and Clinical Immunology, 8 15-25 (2012) [C1]
2011Maltby SJ, Freeman S, Gold MJ, Baker JH, Minchinton AI, Gold MR, et al., 'Opposing Roles for CD34 in B16 Melanoma Tumor Growth Alter Early Stage Vasculature and Late Stage Immune Cell Infiltration', PLoS One, 6 (2011) [C1]
2010Maltby SJ, Wong J, Berberovic Z, Birkenmeier CS, Haddon DJ, Garcha K, et al., 'A novel ENU-generated truncation mutation lacking the spectrin-binding and C-terminal regulatory domains of Ank1 models severe, hemolytic hereditary spherocytosis', Experimental Hematology, 39 601-610 (2010) [C1]
2010Maltby SJ, Wohlfarth C, Gold M, Zbytnuik L, Hughes MR, McNagny KM, 'CD34 is required for infiltration of eosinophils into the colon and pathology associated with DSS-induced ulcerative colitis', American Journal of Pathology, 177 1244-1254 (2010) [C1]
2010Blanchet M-R, Gold M, Maltby SJ, Bennett J, Petri B, Kubes P, et al., 'Loss of CD34 leads to exacerbated autoimmune arthritis through increased vascular permeability', Journal of Immunology, 184 1292-1299 (2010) [C1]
2009Maltby SJ, Hughes MR, Zbytnuik L, Paulson RF, McNagny KM, 'Podocalyxin selectively marks erythroid-committed progenitors during anemic stress but is dispensable for efficient recovery', Experimental Hematology, 37 10-18 (2009) [C1]
2007Blanchet M-R, Maltby SJ, Haddon DJ, Merkens H, Zbytnuik L, McNagny KM, 'CD34 facilitates the development of allergic asthma', Blood, 110 2005-2012 (2007) [C1]
Show 8 more

Review (1 outputs)

YearCitationAltmetricsLink
2009Maltby SJ, Khash K, McNagny KM, 'Mast cells in tumor growth: angiogenesis, tissue remodeling and immune-modulation', Biochimica et biophysica acta - Reviews on Cancer (2009) [D1]

Conference (5 outputs)

YearCitationAltmetricsLink
2012McNagny K, Debruin E, Gold M, Bennett J, Blanchet M-R, Maltby S, Hughes M, 'CD34 family proteins are key regulators of inflammatory cell migration and vascular integrity', JOURNAL OF IMMUNOLOGY, Boston, MA (2012) [E3]
2011Maltby S, Gold M, Wohlfarth C, Blanchet M, McNagny KM, 'CD34 LOCALIZATION IN EOSINOPHILS AT STEADY STATE AND DURING DISEASE', EXPERIMENTAL HEMATOLOGY (2011) [E3]
2008Blanchet M-R, Maltby S, Bennett J, McNagny K, 'Mouse models to study the role of CD34 in allergy and inflammatory diseases', FASEB JOURNAL (2008) [E3]
2007Hughes MR, Anderson N, Maltby S, Wong J, Milenkovic Z, Wang C, et al., 'A new model of hereditary spherocytosis demonstrates profound homeostatic compensation in severely anemic mice.', BLOOD, Atlanta, GA (2007)
2007Hughes MR, Maltby S, Zbytnuik L, Paulson R, McNagny KM, 'Podocalyxin is a selective marker of erythroid progenitors but is dispensable for anemia recovery.', BLOOD, Atlanta, GA (2007)
Show 2 more
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Grants and Funding

Summary

Number of grants6
Total funding$410,834

- Indicates that the researcher may be seeking students for this project.

Click on a grant title below to expand the full details for that specific grant.

2014 (2 grants)

Virus Infections Change the Bone Marrow: Effects on Immunity, Bone Development and Inflammatory Disease$20,000
Funding Body: Hunter Medical Research Institute

Project Team
Doctor Steven Maltby, Mr Max Plank, Doctor Hock Tay, Professor Paul Foster
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$20,00020142014
GNo:G1401394

Inaugural Future of Experimental Medicine Conference: Inflammation in Disease and Ageing, Sydney Australia, 16-19 March 2014$650
Funding Body: University of Newcastle - Faculty of Health and Medicine

Project Team
Doctor Steven Maltby
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$65020142014
GNo:G1400166

2013 (2 grants)

DP73 Digital colour and monochrome camera + cellSens software + Xcite120 fluorescence lamp illuminator$20,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Paul Foster, Doctor Alan Hsu, Professor Phil Hansbro, Professor Joerg Mattes, Doctor Katie Baines, Associate Professor Jodie Simpson, Professor Rakesh Kumar, Doctor Nicole Hansbro, Doctor Steven Maltby, Doctor Ming Yang, Doctor Gerard Kaiko, Doctor Jay Horvat, Doctor Simon Keely, Doctor Andrew Jarnicki, Doctor Michael Fricker
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$20,00020132013
GNo:G1201186

43rd Annual Scientific meeting of the Australasian Society for Immunology (ASI), Wellington New Zealand, 2 - 5 December 2013$1,500
Funding Body: University of Newcastle - Faculty of Health and Medicine

Project Team
Doctor Steven Maltby
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$1,50020132014
GNo:G1300439

2012 (2 grants)

2011 Research Fellowship - DVCR Strategic Appointment (PRCARD)$348,315
Funding Body: University of Newcastle

Project Team
Doctor Steven Maltby
SchemeRole
Research FellowshipChief Investigator
Total AmountFunding StartFunding Finish
$348,31520122015
GNo:G1100534

Fellowship Start-up Grant$20,369
Funding Body: University of Newcastle

Project Team
Doctor Steven Maltby
SchemeRole
Fellowship GrantChief Investigator
Total AmountFunding StartFunding Finish
$20,36920122012
GNo:G1200114
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Research Supervision

Number of current supervisions2
Total current UoN PhD EFTSL0.4

For supervisions undertaken at an institution other that the University of Newcastle, the institution name is listed below the program name.

Current Supervision

CommencedProposed
Completion
ProgramSupervisor TypeResearch Title
20122016PhD (Immunology & Microbiol)Co-SupervisorRoles of Bromodomain and extra terminal (BET) proteins in Suppression of Airway Inflammation
20122016PhD (Immunology & Microbiol)Co-SupervisorUnderstanding the mechanisms of airway hyper-responsiveness in a mouse model of asthma
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Dr Steven Maltby

Work Phone(02) 404 20173
Fax(02) 404 20025
Email
PositionPostdoctoral Research Fellow
FOSTER GROUP
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine
The University of Newcastle, Australia
Office
HMRI 2 East,
HMRI,
NEWCASTLE
URL:www.newcastle.edu.au/profile/steven-maltby