Profile Image

Dr Simon Keely

Senior Lecturer

School of Biomedical Sciences and Pharmacy (Immunology and Microbiology)

Career Summary

Biography

Dr. Keely graduated with a Ph.D. from University College Dublin. He undertook postdoctoral research training at the Mucosal Inflammation Program in University of Colorado Denver before being promoted to junior faculty positions (Instructor and Senior Instructor) in the School of Medicine and receiving a prestigious fellowship from the Crohn's and Colitis Foundation of America. Dr. Keely is chief investigator of the Hunter Medical Research Institute (HMRI) Gastrointestinal Research Group. The group's current research examines molecular mechanisms of disease in the gastrointestinal tract. Dr. Keely is particularly interested in how the mucosal tissues function and repair with reduced oxygen availability during inflammation. Dr. Keely is also interested in the changes that occur with microbial interactions during inflammation and how these interactions influence the progression and resolution of mucosal diseases. The ultimate goal of this research is understanding how these factors may be pharmacologically manipulated for therapeutic benefit.

Research Expertise
The Gastrointestinal Research Group is focused on studying the cellular processes of digestive disease and infection. The group is particularly interested in mucosal inflammation and how tissues adapt to conditions of oxygen deficiency (hypoxia) in inflamed tissue. This is particularly relevant to chronic inflammatory diseases such as the inflammatory bowel diseases (IBD); Crohn's disease & ulcerative colitis. To achieve this, we study cellular mechanisms of inflammation and adaption to inflammation in vitro. We give our findings physiological context by applying them to in vivo models of IBD and then, through our collaborators at John Hunter Hospital, examine human context in patient samples. With this approach, we hope to identify strategies for new therapeutic approaches to treating IBD. Our current, ongoing research: 1) Investigates how wound healing is regulated in the intestine during the inflammation associated with Crohn's disease. 2) Examines the mechanisms leading to IBD-related disease that occurs outside of the gastrointestinal tract. 3) Explores how a new experimental drug, which promotes accelerated remission, regulates the immune system in models of IBD. 4) Examines how pain is regulated in the intestines in chronic IBD.

Teaching Expertise
My teaching covers topics of Immunology, Microbiology and Scientific Skills and Development across a range of degree courses and modules. For 2012 I teach into the following Biomedical Science courses: http://www.newcastle.edu.au/course/HUBS1404.html HUBS1404 Biomedical Science 2 http://www.newcastle.edu.au/course/HUBS1416.html HUBS1416 Advanced Human Bioscience http://www.newcastle.edu.au/course/HUBS2601.html HUBS2601 Human Infection and Immunity 1 http://www.newcastle.edu.au/course/HUBS3602.html HUBS3602 Human Infection and Immunity 2 http://www.newcastle.edu.au/course/HUBS3204.html HUBS3204 Advanced Professional Skills in Biomedical Science In addition I present courses into: http://www.newcastle.edu.au/course/MEDI1015.html MEDI1015 Medical Science 1 http://www.newcastle.edu.au/course/MEDI2014.html MEDI2014 Medical Science 2 http://www.newcastle.edu.au/course/MEDI3018.html MEDI3018 Medical Science 3

Administrative Expertise
Broad expertise and experience in administration and committee panels. Served on international conference and workshop review committees, school and faculty executives and focus group panels. Member of Institutional Biosafety Committee Course Co-ordinator for HUBS3204 NHMRC Grant Review Panel Member 2012

Collaborations
Professor Phil Hansbro, University of Newcastle Professor Alan Baird, University College Dublin, Ireland Professor Sean Colgan, University of Colorado Denver, Colorado, USA Professor Robert Callister, University of Newcastle Dr. Jay Horvat, University of Newcastle


Keywords

  • Cell Biology
  • Crohn's Disease
  • Epithelial Biology
  • Hypoxia
  • Immunology
  • Infection
  • Inflammatory Bowel Disease
  • Microbiology
  • Molecular Biology
  • Mucosal Inflammation
  • Ulcerative Colitis

Languages

  • Irish (Fluent)

Fields of Research

CodeDescriptionPercentage
060199Biochemistry and Cell Biology not elsewhere classified35
110307Gastroenterology and Hepatology35
110799Immunology not elsewhere classified30

Professional Experience

UON Appointment

DatesTitleOrganisation / Department
1/04/2015 - Senior LecturerUniversity of Newcastle
School of Biomedical Sciences and Pharmacy
Australia

Academic appointment

DatesTitleOrganisation / Department
1/01/2012 - Membership - NHMRC GRPNHMRC GRP
Australia
1/01/2011 - Membership - Australian Society for ImmunologyAustralian Society for Immunology
Australia
1/01/2011 - Membership - Gastroenterological Society of AustraliaGastroenterological Society of Australia
1/01/2010 - 1/02/2011Senior InstructorUniversity of Colorado, Denver
Mucosal Inflammation Program
United States
1/12/2009 - 1/02/2011Senior Instructor
Crohn's & Colitis Foundation of America Research Fellow
University of Colorado, Denver
United States
1/12/2008 - 1/12/2009InstructorUniversity of Colorado, Denver
United States
1/11/2008 - 1/01/2010Instructor
Junior Faculty
University of Colorado, Denver
Mucosal Inflammation Program
United States
1/07/2006 - 1/11/2008Postdoctoral Research FellowUniversity of Colorado, Denver
Mucosal Inflammation Program
United States
1/10/2005 - 1/07/2006Postdoctoral Research FellowUniversity College Dublin
School of Veterinary Medicine
Ireland

Awards

Research Award

YearAward
2009Research Fellowship
Unknown
Edit

Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Journal article (24 outputs)

YearCitationAltmetricsLink
2015Marks E, Goggins BJ, Cardona J, Cole S, Minahan K, Mateer S, et al., 'Oral delivery of prolyl hydroxylase inhibitor: AKB-4924 promotes localized mucosal healing in a mouse model of colitis.', Inflamm Bowel Dis, 21 267-275 (2015)
DOI10.1097/MIB.0000000000000277Author URL
Co-authorsMarjorie Walker
2014Keely S, Hansbro PM, 'Lung-Gut Cross Talk A Potential Mechanism for Intestinal Dysfunction in Patients With COPD', CHEST, 145 199-200 (2014) [C3]
DOI10.1378/chest.13-2077Author URL
CitationsScopus - 1Web of Science - 1
Co-authorsPhilip Hansbro
2014Ward JBJ, Keely SJ, Keely SJ, 'Oxygen in the regulation of intestinal epithelial transport', Journal of Physiology, 592 2473-2489 (2014) [C1]

The transport of fluid, nutrients and electrolytes to and from the intestinal lumen is a primary function of epithelial cells. Normally, the intestine absorbs approximately 9 l of fluid and 1 kg of nutrients daily, driven by epithelial transport processes that consume large amounts of cellular energy and O2. The epithelium exists at the interface of the richly vascularised mucosa, and the anoxic luminal environment and this steep O2 gradient play a key role in determining the expression pattern of proteins involved in fluid, nutrient and electrolyte transport. However, the dynamic nature of the splanchnic circulation necessitates that the epithelium can evoke co-ordinated responses to fluctuations in O2 availability, which occur either as a part of the normal digestive process or as a consequence of several pathophysiological conditions. While it is known that hypoxia-responsive signals, such as reactive oxygen species, AMP-activated kinase, hypoxia-inducible factors, and prolyl hydroxylases are all important in regulating epithelial responses to altered O2 supply, our understanding of the molecular mechanisms involved is still limited. Here, we aim to review the current literature regarding the role that O2 plays in regulating intestinal transport processes and to highlight areas of research that still need to be addressed. © 2014 The Physiological Society.

DOI10.1113/jphysiol.2013.270249
CitationsScopus - 1
2014Farrell KE, Keely S, Graham BA, Callister R, Callister RJ, 'A Systematic Review of the Evidence for Central Nervous System Plasticity in Animal Models of Inflammatory-mediated Gastrointestinal Pain', INFLAMMATORY BOWEL DISEASES, 20 176-195 (2014) [C1]
DOI10.1097/01.MIB.0000437499.52922.b1Author URL
CitationsScopus - 2Web of Science - 2
Co-authorsRobert Callister, Robin Callister, Brett Graham
2014Farrell KE, Callister RJ, Keely S, 'Understanding and targeting centrally mediated visceral pain in inflammatory bowel disease', Frontiers in Pharmacology, 5 1-4 (2014) [C3]
DOI10.3389/fphar.2014.00027
Co-authorsRobert Callister
2014Keely S, Campbell EL, Baird AW, Hansbro PM, Shalwitz RA, Kotsakis A, et al., 'Contribution of epithelial innate immunity to systemic protection afforded by prolyl hydroxylase inhibition in murine colitis', Mucosal Immunology, 7 114-123 (2014) [C1]

Pharmacological stabilization of hypoxia-inducible factor (HIF) through prolyl hydroxylase (PHD) inhibition limits mucosal damage associated with models of murine colitis. However, little is known about how PHD inhibitors (PHDi) influence systemic immune function during mucosal inflammation or the relative importance of immunological changes to mucosal protection. We hypothesized that PHDi enhances systemic innate immune responses to colitis-associated bacteremia. Mice with colitis induced by trinitrobenzene sulfonic acid were treated with AKB-4924, a new HIF-1 isoform-predominant PHDi, and clinical, immunological, and biochemical endpoints were assessed. Administration of AKB-4924 led to significantly reduced weight loss and disease activity compared with vehicle controls. Treated groups were pyrexic but did not become subsequently hypothermic. PHDi treatment augmented epithelial barrier function and led to an approximately 50-fold reduction in serum endotoxin during colitis. AKB-4924 also decreased cytokines involved in pyrogenesis and hypothermia, significantly reducing serum levels of interleukin (IL)-1ß, IL-6, and tumor necrosis factor (TNF)-a while increasing IL-10. Treatment offered no protection against colitis in epithelial-specific HIF-1a-deficient mice, strongly implicating epithelial HIF-1a as the tissue target for AKB-4924-mediated protection. Taken together, these results indicate that inhibition of prolyl hydroxylase with AKB-4924 enhances innate immunity and identifies that the epithelium is a central site of inflammatory protection afforded by PHDi in murine colitis. © 2014 Society for Mucosal Immunology.

DOI10.1038/mi.2013.29
CitationsScopus - 8Web of Science - 7
Co-authorsPhilip Hansbro
2013Goggins BJ, Chaney C, Radford-Smith GL, Horvat JC, Keely S, 'Hypoxia and Integrin-Mediated Epithelial Restitution during Mucosal Inflammation.', Front Immunol, 4 272 (2013) [C1]
DOI10.3389/fimmu.2013.00272Author URL
CitationsScopus - 6
Co-authorsJay Horvat
2013Beckett EL, Stevens RL, Jarnicki AG, Kim RY, Hanish I, Hansbro NG, et al., 'A new short-term mouse model of chronic obstructive pulmonary disease identifies a role for mast cell tryptase in pathogenesis', The Journal of Allergy and Clinical Immunology, 131 752-762 (2013) [C1]
CitationsScopus - 29Web of Science - 30
Co-authorsPaul Foster, Jay Horvat, Peter Wark, Nicole Hansbro, Ming Yang, Philip Hansbro
2012Keely S, Talley NJ, Hansbro PM, 'Pulmonary-intestinal cross-talk in mucosal inflammatory disease', Mucosal Immunology, 5 7-18 (2012) [C1]
CitationsScopus - 26Web of Science - 27
Co-authorsNicholas Talley, Philip Hansbro
2012Keely S, Kelly C, Weissmueller T, Burgess A, Wagner B, Robertson CE, et al., 'Activated fluid transport regulates bacterial-epithelial interactions and significantly shifts the murine colonic microbiome', Gut Microbes, 3 250-260 (2012) [C1]
DOI10.4161/gmic.20529
CitationsScopus - 10
2011Kominsky D, Keely S, Macmanus C, Glover L, Scully M, Collins C, et al., 'An Endogenously Anti-Inflammatory Role for Methylation in Mucosal Inflammation Identified through Metabolite Profiling.', Journal of Immunology, 186 6505-6514 (2011) [C1]
DOI10.4049/jimmunol.1002805
CitationsScopus - 18Web of Science - 17
2011Macmanus C, Campbell E, Keely S, Adrienne B, Kominsky D, Colgan S, 'Anti-inflammatory actions of adrenomedullin through fine tuning of HIF stabilization', The FASEB Journal, 25 1856-1864 (2011) [C1]
DOI10.1096/fj.10-170316
CitationsScopus - 20Web of Science - 18
2011Keely S, Feighery L, Campion DP, O'Brien L, Brayden DJ, Baird AW, 'Chloride-led disruption of the intestinal mucous layer impedes salmonella invasion: Evidence for an 'enteric tear' mechanism', Cellular Physiology and Biochemistry, 28 743-752 (2011) [C1]
CitationsScopus - 3Web of Science - 3
2010Campbell E, Macmanus C, Kominsky D, Keely S, Glover L, Scully M, et al., 'Resolvin E1-induced Intestinal Alkaline Phosphatase Promotes Resolution of Inflammation through LPS detoxification.', Proceedings of the National Academy of Sciences of USA, 107 4298-4303 (2010) [C1]
DOI10.1073/pnas.0914730107
CitationsScopus - 50Web of Science - 39
2010Keely S, Glover L, Weissmueller T, Macmanus C, Fillon S, Fennimore B, Colgan S, 'Hypoxia-inducible factor-dependent regulation of platelet-activating factor receptor as a route for gram-positive bacterial translocation across epithelia', Molecular Biology of the Cell, 21 538-546 (2010) [C1]
DOI10.1091/mbc.E09-07-0573
CitationsScopus - 23Web of Science - 22
2009Keely S, Ryan S, Haddleton D, Limer A, Mantovani G, Murphy E, Brayden D, 'Dexamethasone-pDMAEMA polymeric conjugates reduce inflammatory biomarkers in human intestinal epithelial monolayers.', Journal of Controlled Release, 135 35-43 (2009) [C1]
DOI10.1016/j.jconrel.2008.12.001
CitationsScopus - 17Web of Science - 18
2009Keely S, Glover L, Macmanus C, Campbell E, Scully M, Furuta G, Colgan S, 'Selective induction of integrin beta1 by hypoxia-inducible factor: implications for wound healing.', The FASEB Journal, 23 1338-1346 (2009) [C1]
DOI10.1096/fj.08-125344
CitationsScopus - 28
2008Fanning R, Campion D, Collins C, Keely S, Briggs L, O'Connor J, Carey M, 'A comparison of the inhibitory effects of bupivacaine and levobupivacaine on isolated human pregnant myometrium contractility.', Anesthesia and Analgesia, 107 1303-1307 (2008) [C1]
DOI10.1213/ane.0b013e3181804245
CitationsScopus - 6Web of Science - 4
2008Boland T, Hayes L, Sweeney T, Callanan J, Baird A, Keely S, Crosby T, 'The effects of cobalt and iodine supplementation of the pregnant ewe diet on immunoglobulin G, vitamin E, T-3 and T-4 levels in the progeny.', Animal: the international journal of animal biosciences, 2 197-206 (2008) [C1]
DOI10.1017/S175173110700105X
CitationsScopus - 9Web of Science - 9
2008Robinson A, Keely S, Karhausen J, Gerich M, Furuta G, Colgan S, 'Mucosal protection by hypoxia-inducible factor prolyl hydroxylase inhibition.', Gastroenterology, 134 346-348 (2008) [C1]
DOI10.1053/j.gastro.2007.09.033
CitationsScopus - 146Web of Science - 139
2008Feighery L, Smyth A, Keely S, Baird A, O'Connor W, Callanan J, Brayden D, 'Increased intestinal permeability in rats subjected to traumatic frontal lobe percussion brain injury.', Journal of Trauma: Injury Infection and Critical Care, 64 131-137 (2008) [C1]
DOI10.1097/TA.0b013e3181568d9f
CitationsScopus - 14Web of Science - 14
2008Keely S, Rawlinson L-AB, Haddleton DM, Brayden DJ, 'A tertiary amino-containing polymethacrylate polymer protects mucus-covered intestinal epithelial monolayers against pathogenic challenge', Pharmaceutical Research, 25 1193-1201 (2008) [C1]
DOI10.1007/s11095-007-9501-3
CitationsScopus - 11Web of Science - 10
2006Limer A, Attvinder R, San Miguel V, Peinado C, Keely S, Fitzpatrick E, et al., 'Fluorescently tagged star polymers by living radical polymerisation for mucoadhesion and bioadhesion.', Reactive and Functional Polymers, 66 51-64 (2006) [C1]
DOI10.1016/j.reactfunctpolym.2005.07.024
2005Keely S, Atvinder R, Wilson C, Carmichael A, Carrington S, Corfield A, et al., 'In vitro and ex vivo intestinal tissue models to measure mucoadhesion of poly (methacrylate) and N-trimethylated chitosan polymers.', Pharmaceutical Research, 22 38-49 (2005) [C1]
DOI10.1007/s11095-004-9007-1
Show 21 more journal articles

Conference (16 outputs)

YearCitationAltmetricsLink
2014Cardona J, Marks E, Goggins B, Mateer S, Minahan K, Horvat J, Keely S, 'The role of antibiotics in the development of food allergy', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2014) [E3]
Author URL
Co-authorsJay Horvat
2014Marks E, Nolan G, Mateer S, Minahan K, Goggins B, Cardona J, Keely S, 'Hypoxia inducible factor 1 alpha (HIF-1 alpha) regulates anti-inflammatory lymphoid responses during colitis', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2014) [E3]
Author URL
2014Mateer S, Maltby S, Marks E, Goggins B, Horvat J, Hansbro P, Keely S, 'Immune cell mis-homing drives secondary organ inflammation in inflammatory bowel disease; a focus on the respiratory system', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2014) [E3]
Author URL
Co-authorsPhilip Hansbro, Steven Maltby, Jay Horvat
2014Farrell KE, Graham BA, Keely S, Callister RJ, 'Understanding the mechanisms underlying chronic pain in IBD: A new method for studying visceral inputs from the gastrointestinal tract', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2014) [E3]
Author URL
Co-authorsRobert Callister, Brett Graham
2014Fathi F, Hsu A, Parsons K, Keely S, Wood L, Wark P, 'OXIDATIVE STRESS IMPAIRS MITOCHONDRIAL FUNCTION AND LEADS TO DEFICIENT ANTIVIRAL RESPONSES IN PRIMARY BRONCHIAL EPITHELIAL CELLS', RESPIROLOGY (2014) [E3]
DOI10.1111/resp.12263_3Author URL
Co-authorsAlan Hsu, Lisa Wood, Peter Wark
2013Hansbro P, Beckett E, Stevens R, Jarnicki A, Kim R, Hanish I, et al., 'A short-term model of COPD identifies a role for mast cell tryptase', JOURNAL OF IMMUNOLOGY, Honolulu, HI (2013) [E3]
Author URL
Co-authorsMing Yang, Philip Hansbro, Nicole Hansbro, Paul Foster, Jay Horvat, Peter Wark
2012Farrell KE, Keely S, Graham BA, Minahan KL, Madden JF, Callister RJ, 'Spinal cord signalling in a mouse model of inflammatory bowel disease', Journal of Gastroenterology and Hepatology, Adelaide, SA (2012) [E3]
Co-authorsBrett Graham, Robert Callister
2012Nolan GM, Minahan KL, Farrell KE, Chaney C, Mateer S, Talley NJ, Keely S, 'Hypoxia-inducible factor-1 a promotes mucosal protection in colitis via the IL-12 signalling pathway', Journal of Gastroenterology and Hepatology, Adelaide, S.A. (2012) [E3]
Co-authorsNicholas Talley
2012Mateer S, Hansbro PM, Nolan GM, Chaney C, Minahan KL, Keely S, 'Development of pulmonary inflammation and altered lung function in a mouse model of colitis', Journal of Gastroenterology and Hepatology, Adelaide, S.A. (2012) [E3]
Co-authorsPhilip Hansbro
2012Keely S, Baird AW, Colgan S, 'Epithelial HIF-1 a is critical to the protective action of prolyl hydroxylase inhibition in a murine model of inflammatory bowel disease', Journal of Gastroenterology and Hepatology, Adelaide, S.A. (2012) [E3]
2012Chaney C, Minahan KL, Mateer S, Nolan GM, Talley NJ, Keely S, 'Hypoxic regulation of ß1 integrin during mucosal wound healing', Journal of Gastroenterology and Hepatology, Adelaide, S.A. (2012) [E3]
Co-authorsNicholas Talley
2012Keely S, Baird A, Kominsky D, McNamee EN, Hansbro PM, Shalwitz RA, Colgan SP, 'Immune modulation by prolyl hydroxylase inhibition contributes to the prevention of endotoxemia in a murine model of inflammatory bowel disease', FASEB Journal, San Diego, California (2012) [E3]
Co-authorsPhilip Hansbro
2011Kominsky D, Keely S, Macmanus C, Glover L, Scully M, Collins C, et al., 'Cellular methylation plays an anti-inflammatory role in Mucosal Inflammation', Inflammatory Bowel Diseases, Hollywood, Florida (2011) [E3]
2011Keely S, Baird A, Kominsky D, Campbell E, Burgess A, Colgan S, 'HIF prolyl hydroxylase inhibition reverses disease symptoms in established TNBS colitis', Inflammatory Bowel Diseases, Hollywood, Florida (2011) [E3]
2011Campbell E, Macmanus C, Kominsky D, Keely S, Glover L, Bowers B, et al., 'Resolvin E1-induced intestinal alkaline phosphatase promotes resolution of inflammation through LPS detoxification', Inflammatory Bowel Diseases, Hollywood, Florida (2011) [E3]
2011Kominsky D, Keely S, Campbell E, Christopher M, Scully M, Collins C, et al., 'A central role of methylation in mucosal inflammation', Inflammatory Bowel Diseases, Hollywood, Florida (2011) [E3]
Show 13 more conferences
Edit

Grants and Funding

Summary

Number of grants17
Total funding$1,903,478

Click on a grant title below to expand the full details for that specific grant.


20153 grants / $492,026

Chlamydia and reproductive health $475,526

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project Team
SchemeProject Grant
RoleInvestigator
Funding Start2015
Funding Finish2018
GNo
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Too Much of a Good Thing: Application for a triple-gas incubator to allow cell culture under normal conditions$14,500

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Craig Gedye, Professor Rodney Scott, Doctor Nikola Bowden, Doctor Simon Keely, Doctor Kathryn Skelding
SchemeResearch Grant
RoleInvestigator
Funding Start2015
Funding Finish2015
GNoG1500730
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

Experimental Biology 2015, Boston USA, 26 March-1 April 2015$2,000

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding bodyUniversity of Newcastle - Faculty of Health and Medicine
Project TeamDoctor Simon Keely
SchemeTravel Grant
RoleLead
Funding Start2015
Funding Finish2015
GNoG1500204
Type Of FundingInternal
CategoryINTE
UONY

20144 grants / $583,226

Spinal processing of sensory signals from the gut$536,226

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Robert Callister, Doctor Simon Keely, Doctor Brett Graham, Professor Alan Brichta, Dr David Hughes
SchemeProject Grant
RoleInvestigator
Funding Start2014
Funding Finish2014
GNoG1300361
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Activating natural protective and healing responses in chronic inflammatory bowel disease$25,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Simon Keely, Doctor Ellen Marks, Associate Professor Martin Veysey
SchemeResearch Grant
RoleLead
Funding Start2014
Funding Finish2014
GNoG1401453
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

The role of the microbiome in the development of food allergy$20,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Simon Keely, Doctor Jay Horvat
SchemeProject Grant
RoleLead
Funding Start2014
Funding Finish2014
GNoG1301344
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

Experimental Biology 2014, San Diego USA, 26-30 April 2014$2,000

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding bodyUniversity of Newcastle - Faculty of Health and Medicine
Project TeamDoctor Simon Keely
SchemeTravel Grant
RoleLead
Funding Start2014
Funding Finish2014
GNoG1400253
Type Of FundingInternal
CategoryINTE
UONY

20132 grants / $22,000

DP73 Digital colour and monochrome camera + cellSens software + Xcite120 fluorescence lamp illuminator$20,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamLaureate Professor Paul Foster, Doctor Alan Hsu, Professor Phil Hansbro, Professor Joerg Mattes, Doctor Katie Baines, Associate Professor Jodie Simpson, Professor Rakesh Kumar, Doctor Nicole Hansbro, Doctor Steven Maltby, Doctor Ming Yang, Doctor Gerard Kaiko, Doctor Jay Horvat, Doctor Simon Keely, Doctor Andrew Jarnicki, Doctor Michael Fricker
SchemeEquipment Grant
RoleInvestigator
Funding Start2013
Funding Finish2013
GNoG1201186
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

United European Gastroenterology Week, Berlin, 12 -16 October 2013$2,000

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding bodyUniversity of Newcastle - Faculty of Health and Medicine
Project TeamDoctor Simon Keely
SchemeTravel Grant
RoleLead
Funding Start2013
Funding Finish2013
GNoG1300842
Type Of FundingInternal
CategoryINTE
UONY

20123 grants / $364,226

The Role of Hypoxia in Wound Healing During Mucosal Inflammation$312,726

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamDoctor Simon Keely
SchemeProject Grant
RoleLead
Funding Start2012
Funding Finish2012
GNoG1100095
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

SpectraMax M5e Multi-Mode Microplate Reader$50,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamLaureate Professor Paul Foster, Professor Phil Hansbro, Professor Joerg Mattes, Professor Rakesh Kumar, Doctor Nicole Hansbro, Doctor Ming Yang, Doctor Jay Horvat, Doctor Simon Keely, Doctor Andrew Jarnicki, Doctor Linda Howland, Doctor Kelly Asquith
SchemeEquipment Grant
RoleInvestigator
Funding Start2012
Funding Finish2012
GNoG1100975
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

Experimental Biology 2012, San Diego, USA, 21 - 25 April 2012$1,500

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding bodyUniversity of Newcastle - Faculty of Health and Medicine
Project TeamDoctor Simon Keely
SchemeTravel Grant
RoleLead
Funding Start2012
Funding Finish2012
GNoG1200426
Type Of FundingInternal
CategoryINTE
UONY

20112 grants / $46,500

SCIREQ FlexiVentFX system + FlexiVentFX extension$45,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Phil Hansbro, Laureate Professor Paul Foster, Professor Joerg Mattes, Doctor Simon Keely, Doctor Jay Horvat, Doctor Nicole Hansbro, Doctor Ming Yang, Doctor Catherine Ptaschinski, Doctor Kelly Asquith, Doctor Gough Au, Conjoint Professor Peter Wark, Laureate Professor John Aitken, Conjoint Professor Keith Jones, Professor Roger Smith, Professor Judith Black, Professor Rakesh Kumar, Professor Paul Hertzog
SchemeEquipment Grant
RoleInvestigator
Funding Start2011
Funding Finish2011
GNoG1100037
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

Gastrointestinal Tract: XIV: Stems Cells, Adaptation, Inflammation and Cancer, Steamboat Sprngs, Colorado, USA, 14 - 18 August 2011$1,500

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding bodyUniversity of Newcastle - Faculty of Health and Medicine
Project TeamDoctor Simon Keely
SchemeTravel Grant
RoleLead
Funding Start2011
Funding Finish2011
GNoG1100679
Type Of FundingInternal
CategoryINTE
UONY

20092 grants / $335,500

Influence of Hypoxia and HIF Activation on Intestinal Epithelial Restitution via Integrin Signaling$175,500

Funding body: Crohn's and Colitis Foundation of America

Funding bodyCrohn's and Colitis Foundation of America
Project Team
SchemeResearch Fellowship
RoleLead
Funding Start2009
Funding Finish2011
GNo
Type Of FundingInternational - Competitive
Category3IFA
UONY

Microbiome adaption during intestinal fluid transport$160,000

Funding body: Takeda Pharmaceuticals North America, Inc

Funding bodyTakeda Pharmaceuticals North America, Inc
Project Team
SchemeInvestigator Initiated - Sponsored Research
RoleInvestigator
Funding Start2009
Funding Finish2011
GNo
Type Of FundingNot Known
CategoryUNKN
UONY

20071 grants / $60,000

Influence of intestinal fluid transport on bacterial invasion.$60,000

Funding body: Takeda Pharmaceuticals North America, Inc

Funding bodyTakeda Pharmaceuticals North America, Inc
Project Team
SchemeInvestigator Initiated - Sponsored Research
RoleInvestigator
Funding Start2007
Funding Finish2008
GNo
Type Of FundingInternational - Competitive
Category3IFA
UONY
Edit

Research Supervision

Current Supervision

CommencedResearch Title / Program / Supervisor Type
2014Hypoxia Inducible Factor (HIF)-1 mediates epithelial wound healing through integrin regulation
Microbiology, Faculty of Health and Medicine
Principal Supervisor
2014Peripheral Opioid Receptor Targeting for the Relief of Pain, Inflammation and Disease Progression in Rheumatoid Arthritis
Pharmacy, Faculty of Health and Medicine
Co-Supervisor
2013Investigation of the pathogenesis and potential therapeutic interventions of influenza in Asthma and COPD
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2011Spinal Cord Signalling in a Mouse Model of IBD
Human Biology, Faculty of Health and Medicine
Co-Supervisor
2011Mechanisms of Predisposition to Secondary Bacterial Pneumonia
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2011The Role of Innate Cells in Infectious Exacerbation of COPD
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2011Investigation of Pathogenesis of Chronic Obstructive Pulmonary Disease (COPD)
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2011Identifying the Mechanisms of Lung Inflammation Associated with Inflammatory Bowel Disease
Microbiology, Faculty of Health and Medicine
Principal Supervisor
2010The Role of PAFr in Intestinal Inflammation
Medical Science, Unknown
Co-Supervisor
Edit

Dr Simon Keely

Position

Senior Lecturer
Gastrointestinal Research Group
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

Focus area

Immunology and Microbiology

Contact Details

Emailsimon.keely@newcastle.edu.au
Phone(02) 4042 0229 (HMRI)
Fax(02) 4042 0026 (HMRI)

Office

RoomRm 2413, Level 2 East Wing (HMRI) LS2-39 (Callaghan)
BuildingHMRI - Life Sciences Building (Callaghan)
LocationHunter Medical Research Institute and Callaghan Campus
University Drive
Callaghan, NSW 2308
Australia
Edit