Profile Image

Dr Shaun Roman

Senior Lecturer

School of Environmental and Life Sciences (Biological Sciences)

Career Summary

Biography

I arrived at the University of Newcastle in 1998 to take up a part time teaching appointment and was promoted to Lecturer as of 1 Jan 2005. Since arriving at the University, as well as developing a teaching profile based on 200+ contact hours per annum, I have established myself as a researcher in the area of early male germ cell differentiation. I am now producing consistent output: I have coauthored 1 book chapter and 9 manuscripts in the last 4 years as well as 28 conference presentations. I have presented my work nationally and internationally (American Society of Andrology, USA, Phoenix USA 2003, UK Environmental Mutagenesis Society & 3rd International Congress on Male Mediated Developmental Toxicity, Bradford UK, 2005). As an indication of the continual rise in my profile I recently chaired a session at a national meeting (Australian Society of Reproductive Biology).

I currently serve on the Program Organising Committee for the 2007 annual meeting of the Society. I regularly review manuscripts for journals in both the Reproductive and Developmental biology fields. Student outcomes: I have successfully cosupervised Honours students with 7/10 awarded First Class since 1999. I have successfully supervised, as sole supervisor, one PhD student to completion (R. Baleato, PhD awarded 2005) with a publication in a high impact journal. Dr Baleatos thesis was unanimously praised by the assessors as being of a high standard. I have cosupervised two PhD students to completion M Wade (PhD awarded 2004) and J Holt (PhD awarded 2006). Both students have generated significant publications from their PhD projects. I currently cosupervise one student who is generating a manuscript for submission. I have been interviewed by various media (Fairfax 2004, 2006, NBN television 2005, The Medical Journal of Australia 2005). I have briefed government authorities on the neglected role of the male in the health of the offspring: Presentation to the Dept of Health and Aging, Office of Chemical Safety, Science Forum: Endocrine Disruptors: A Human Health Problem? Canberra, 2005.

Research Expertise
My experience is in gene expression and regulation, initially in breast cancer (Clarke et. al., 1990, 1991, Roman et. al., 1992, 1993). That work was focused on the role of retinoids in regulating gene expression in breast cancer and includes the initial description of the relationship between retinoid receptors and steroid hormone receptor status (Roman et. al., 1992). Retinoids are now part of the clinical arsenal employed in breast cancer treatment. On the basis of my interest in retinoids, I became interested in retinoids and stem cell biology (Lane et. al, 1999). That work involved metabolic profiling of embryonic stem cells. After a brief hiatus in the field of immunology, I arrived in Newcastle. My experience in the regulation of gene expression lead me to establish a number of techniques if use in Reproductive Science such as subtractive hybridisation and microarray analysis. Using these approaches and a number of other techniques we have cloned and characterised a number of genes (e.g. Curry et. al., 2004, Holt et. al., 2006).

In summary I have moved across fields, in the majority of cases employing new techniques to generate outcomes. I have now established a group focused on early germ cell differentiation. We have isolated spermatogonia and characterised gene expression in these cells. In particular we have sought to explain the arrested spermatogenesis found with vitamin A deficiency (Baleato et. al., 2005). Along with Prof R. John Aitken and Dr Eileen McLaughlin, I represent the Newcastle hub of the ARC Centre of Excellence in Biotechnology and Development. Dr McLaughlin and I supervise a programme within the Centre that has the immortalisation of spermatogonial stem cells as its goal. I also cosupervise a PhD project with Prof David Jans (Monash) addressing the role DNA packaging in DNA damage. Prof Aitken and I collaborate on the role of environmental exposure in generating DNA damage in the male germ line (Aitken et. al., 2006, 2007).

Teaching Expertise
I am engaged in extensive teaching. I coordinate 3 courses of which ones is a core second year Biotech course (60+ students), one is the molecular lab skills course (80+ students) and one is a core 3rd year Biotech course (30+ students). I also teach into the 3rd year molecular biology course. I believe students are engaged by inquiry-based learning. My teaching approach involves the use of innovative teaching techniques to encourage inquiry-based learning. I believe that I am achieving this in all my courses. My student evaluation of teaching scores and comments suggest students perceive me as being enthusiastic, approachable and someone who will explain difficult concepts to the students. In general the students are motivated towards self-learning. One outcome is the students choose to do research placements and Honours with me and the outcome from that path is a graduate highly skilled in research. Students who do not go onto research have acquired life skills. In particular critical analysis and presentation skills are enhanced by the students exposure to my teaching.

Since my arrival at the University of Newcastle I have been extensively involved in curriculum design. I have generated or revised curriculum in at least one course per annum for the last eight years. I have introduced courses. In the last 2 years I have been the initiator of, and one of the driving forces behind, the extensive changes in the Biology curricula such that separate theoretical and practical courses are now taught. This separation has allowed for greater capacity, flexibility and a more focused learning experience. While it is too early for a complete evaluation all early feedback from students has been positive. I have generated both problem-based learning and inquiry-based learning curriculum. I presented on Peer Evaluation in Groupwork at the UniServe Science Symposium (Oct 2004).

Administrative Expertise
I coordinate 3 courses with all the associated administration that entails. I have acted as chair of an informal Biology Discipline Curriculum Committee. The Committee developed and implemented the changes to the Biology curriculum detailed in the teaching statement. As part of the implementation I also act as informal timetabling officer for the Biology Discipline. I was an active participant in the informal meetings within the then Faculty of Science and Mathematics that ultimately lead to the Early Career Researcher Proposal. I was one of the original signatories to that proposal, which lead to recognition and support of ECRs by the Faculty of Science and IT. I served as the Early Career Researcher representative on the Faculty Research Committee of the Faculty of Science and IT for 12 months from February 2002. I organised and chaired the 2002 ForefronT conference, showcasing the research of ECRs within the Faculty of Science and IT. The conference was attended by the VC. I presented at the 2003 conference. I drafted, in collaboration with Dr. Michelle Adams, the Guidelines for Scientific Evaluation of Animal Ethics Applications by the FRC of the Faculty of Science and IT. I served on the selection committee for two research appointments within the Reproductive Science group.


Qualifications

  • PhD, University of New South Wales
  • Bachelor of Science, Flinders University
  • Bachelor of Science (Honours), Flinders University

Keywords

  • Cellular Biotechnology
  • Gene Expression
  • Molecular Biology
  • Reproductive Biology
  • Signal Transduction
  • Spermatogenesis
  • Stem Cell Biology
  • Vitamin A metabolism

Fields of Research

CodeDescriptionPercentage
060699Physiology not elsewhere classified50
110199Medical Biochemistry and Metabolomics not elsewhere classified15
060199Biochemistry and Cell Biology not elsewhere classified35

Professional Experience

UON Appointment

DatesTitleOrganisation / Department
1/01/2015 - Senior LecturerUniversity of Newcastle
School of Environmental and Life Sciences
Australia
11/09/2008 - 25/09/2008Casual AcademicUniversity of Newcastle
School of Environmental and Life Sciences
Australia

Academic appointment

DatesTitleOrganisation / Department
1/05/1999 - 1/12/2004Associate LecturerUniversity of Newcastle
School of Environmental and Life Sciences
Australia
1/06/1998 - 1/05/1999Part time Associate LecturerUniversity of Newcastle
School of Environmental and Life Sciences
Australia

Membership

DatesTitleOrganisation / Department
Past Member - Aust Society for Medical ResearchAustralian Society for Medical Research (ASMR)
Australia
Member - Aust Society for Biochemistry & Molecular BiologyAustralian Society for Biochemistry and Molecular Biology
Australia
1/01/2007 - 31/12/2007Program Organising Committee MemberAustralian Society for Reproductive Biology
Australia

Invitations

Participant

YearTitle / Rationale
2006Cytochrome P450 2E2 Mediates Acrylamide Damage to the Male Germ Line
Organisation: Lorne Genome Description: This abstract was chosen for oral presentation at the opening session of the 2006 Lorne Genome Conference.
2005Science Forum: Endocrine Disruptors: A Human Health Problem?
Organisation: Dept of Health and Aging, Office of Chemical Safety Description: Invited to present at briefing session.
Edit

Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Chapter (2 outputs)

YearCitationAltmetricsLink
2008Aitken RJ, Roman SD, 'Antioxidant systems and oxidative stress in the testes', Molecular Mechanisms in Spermatogenesis, Landes Bioscience, Austin, Texas 154-171 (2008) [B1]
CitationsWeb of Science - 25
Co-authorsJohn Aitken
2007Aitken RJ, Roman SD, Baker MA, De Iuliis GN, 'Redox regulation of DNA damage in the male germ line', Male-Mediated Developmental Toxicity, Royal Society of Chemistry, London, United Kingdom 197-209 (2007) [B1]
CitationsWeb of Science - 2
Co-authorsMark Baker, Geoffry DeiuliIs, John Aitken

Journal article (32 outputs)

YearCitationAltmetricsLink
2015Katen AL, Roman SD, 'The genetic consequences of paternal acrylamide exposure and potential for amelioration', Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 777 91-100 (2015)

Acrylamide is a toxin that humans are readily exposed to due to its formation in many carbohydrate rich foods cooked at high temperatures. Acrylamide is carcinogenic, neurotoxic a... [more]

Acrylamide is a toxin that humans are readily exposed to due to its formation in many carbohydrate rich foods cooked at high temperatures. Acrylamide is carcinogenic, neurotoxic and causes reproductive toxicity when high levels of exposure are reached in mice and rats. Acrylamide induced effects on fertility occur predominantly in males. Acrylamide exerts its reproductive toxicity via its metabolite glycidamide, a product which is only formed via the cytochrome P450 detoxifying enzyme CYP2E1. Glycidamide is highly reactive and forms adducts with DNA. Chronic low dose acrylamide exposure in mice relevant to human exposure levels results in significantly increased levels of DNA damage in terms of glycidamide adducts in spermatocytes, the specific germ cell stage where Cyp2e1 is expressed. Since cells in the later stages of spermatogenesis are unable to undergo DNA repair, and this level of acrylamide exposure causes no reduction in fertility, there is potential for this damage to persist until sperm maturation and fertilisation. Cyp2e1 is also present within epididymal cells, allowing for transiting spermatozoa to be exposed to glycidamide. This could have consequences for future generations in terms of predisposition to diseases such as cancer, with growing indications that paternal DNA damage can be propagated across multiple generations. Since glycidamide is the major contributor to DNA damage, a mechanism for preventing these effects is inhibiting the function of Cyp2e1. Resveratrol is an example of an inhibitor of Cyp2e1 which has shown success in reducing damage caused by acrylamide treatment in mice.

DOI10.1016/j.mrfmmm.2015.04.008
2015Reid AT, Anderson AL, Roman SD, McLaughlin EA, McCluskey A, Robinson PJ, et al., 'Glycogen synthase kinase 3 regulates acrosomal exocytosis in mouse spermatozoa via dynamin phosphorylation.', FASEB J, 29 2872-2882 (2015)
DOI10.1096/fj.14-265553Author URL
Co-authorsEileen Mclaughlin, Adam Mccluskey, John Aitken, Brett Nixon
2014Nixon BJ, Katen AL, Stanger SJ, Schjenken JE, Nixon B, Roman SD, 'Mouse spermatocytes express CYP2E1 and respond to acrylamide exposure', PLoS ONE, 9 (2014) [C1]

Metabolism of xenobiotics by cytochrome P450s (encoded by the CYP genes) often leads to bio-activation, producing reactive metabolites that interfere with cellular processes and c... [more]

Metabolism of xenobiotics by cytochrome P450s (encoded by the CYP genes) often leads to bio-activation, producing reactive metabolites that interfere with cellular processes and cause DNA damage. In the testes, DNA damage induced by xenobiotics has been associated with impaired spermatogenesis and adverse effects on reproductive health. We previously reported that chronic exposure to the reproductive toxicant, acrylamide, produced high levels of DNA damage in spermatocytes of Swiss mice. CYP2E1 metabolises acrylamide to glycidamide, which, unlike acrylamide, readily forms adducts with DNA. Thus, to investigate the mechanisms of acrylamide toxicity in mouse male germ cells, we examined the expression of the CYP, CYP2E1, which metabolises acrylamide. Using Q-PCR and immunohistochemistry, we establish that CYP2E1 is expressed in germ cells, in particular in spermatocytes. Additionally, CYP2E1 gene expression was upregulated in these cells following in vitro acrylamide exposure (1 µM, 18 h). Spermatocytes were isolated and treated with 1 µM acrylamide or 0.5 µM glycidamide for 18 hours and the presence of DNA-adducts was investigated using the comet assay, modified to detect DNA-adducts. Both compounds produced significant levels of DNA damage in spermatocytes, with a greater response observed following glycidamide exposure. A modified comet assay indicated that direct adduction of DNA by glycidamide was a major source of DNA damage. Oxidative stress played a small role in eliciting this damage, as a relatively modest effect was found in a comet assay modified to detect oxidative adducts following glycidamide exposure, and glutathione levels remained unchanged following treatment with either compound. Our results indicate that the male germ line has the capacity to respond to xenobiotic exposure by inducing detoxifying enzymes, and the DNA damage elicited by acrylamide in male germ cells is likely due to the formation of glycidamide adducts. © 2014 Nixon et al.

DOI10.1371/journal.pone.0094904
CitationsScopus - 1
Co-authorsBrett Nixon
2013McIver SC, Roman SD, Nixon B, McLaughlin EA, Loveland KL, 'The rise of testicular germ cell tumours: The search for causes, risk factors and novel therapeutic targets [v1; ref status: Indexed, http://f1000r.es/md]', F1000 Research, 2 1-12 (2013) [C1]
DOI10.12688/f1000research.2-55.v2
Co-authorsEileen Mclaughlin, Brett Nixon
2013McIver SM, Roman SD, Nixon B, Loveland KL, McLaughlin EA, 'The rise of testicular germ cell tumours: the search for causes, risk factors and novel therapeutic targets', F1000Research, 2:55 (doi: 10.12688/f1000research.2-55.v1) 55-66 (2013)
CitationsScopus - 1
Co-authorsBrett Nixon, Eileen Mclaughlin
2013McIver SC, Loveland KL, Roman SD, Nixon B, Kitazawa R, McLaughlin EA, 'The chemokine CXCL12 and its receptor CXCR4 are implicated in human seminoma metastasis', ANDROLOGY, 1 517-529 (2013) [C1]
DOI10.1111/j.2047-2927.2013.00081.xAuthor URL
CitationsScopus - 8Web of Science - 9
Co-authorsEileen Mclaughlin, Brett Nixon
2012Reid AT, Lord T, Stanger SJ, Roman SD, McCluskey A, Robinson PJ, et al., 'Dynamin regulates specific membrane fusion events necessary for acrosomal exocytosis in mouse spermatozoa', Journal of Biological Chemistry, 287 37659-37672 (2012) [C1]
CitationsScopus - 10Web of Science - 9
Co-authorsBrett Nixon, John Aitken, Adam Mccluskey
2012Sutherland JM, Keightley RA, Nixon B, Roman SD, Robker RL, Russell DL, McLaughlin EA, 'Suppressor of cytokine signaling 4 (SOCS4): Moderator of ovarian primordial follicle activation', Journal of Cellular Physiology, 227 1188-1198 (2012) [C1]
CitationsScopus - 8Web of Science - 7
Co-authorsBrett Nixon, Eileen Mclaughlin
2012Sobinoff AP, Pye VJ, Nixon B, Roman SD, McLaughlin EA, 'Jumping the gun: Smoking constituent BaP causes premature primordial follicle activation and impairs oocyte fusibility through oxidative stress', Toxicology and Applied Pharmacology, 260 70-80 (2012) [C1]
CitationsScopus - 21Web of Science - 19
Co-authorsBrett Nixon, Eileen Mclaughlin
2012Sobinoff AP, Nixon B, Roman SD, McLaughlin EA, 'Staying alive: PI3K pathway promotes primordial follicle activation and survival in response to 3MC-induced ovotoxicity', Toxicological Sciences, 128 258-271 (2012) [C1]
CitationsScopus - 15Web of Science - 14
Co-authorsBrett Nixon, Eileen Mclaughlin
2012Nixon BJ, Stanger SJ, Nixon B, Roman SD, 'Chronic exposure to acrylamide induces DNA damage in male germ cells of mice', Toxicological Sciences, 129 135-145 (2012) [C1]
CitationsScopus - 10Web of Science - 7
Co-authorsBrett Nixon
2012McIver SC, Roman SD, Nixon B, McLaughlin EA, 'miRNA and mammalian male germ cells', Human Reproduction Update, 18 44-59 (2012) [C1]
CitationsScopus - 39Web of Science - 37
Co-authorsBrett Nixon, Eileen Mclaughlin
2012McIver SC, Stanger SJ, Santarelli DMF, Roman SD, Nixon B, McLaughlin EA, 'A unique combination of male germ cell mirnas coordinates gonocyte differentiation', PLoS One, 7 1-14 (2012) [C1]
CitationsScopus - 19Web of Science - 15
Co-authorsBrett Nixon, Eileen Mclaughlin
2011Sobinoff AP, Mahony M, Nixon B, Roman SD, McLaughlin EA, 'Understanding the villain: DMBA-induced preantral ovotoxicity involves selective follicular destruction and primordial follicle activation through PI3K/Akt and mTOR signaling', Toxicological Sciences, 123 563-575 (2011) [C1]
CitationsScopus - 21Web of Science - 20
Co-authorsBrett Nixon, Eileen Mclaughlin
2010Sobinoff AP, Pye VJ, Nixon B, Roman SD, McLaughlin EA, 'Adding insult to injury: Effects of xenobiotic-induced preantral ovotoxicity on ovarian development and oocyte fusibility', Toxicological Sciences, 118 653-666 (2010) [C1]
DOI10.1093/toxsci/kfq272
CitationsScopus - 17Web of Science - 16
Co-authorsEileen Mclaughlin, Brett Nixon
2008Aitken RJ, Roman SD, 'Antioxidant systems and oxidative stress in the testes (Reprinted from Molecular Mechanisms in Spermatogenesis, 2007)', OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 1 15-24 (2008) [C3]
Author URL
CitationsScopus - 91Web of Science - 70
Co-authorsJohn Aitken
2006Holt JE, Roman SD, Aitken RJ, McLaughlin EA, 'Identification and characterization of a novel Mt-retrotransposon highly represented in the female mouse germline', Genomics, 87 490-499 (2006) [C1]
DOI10.1016/j.ygeno.2005.08.015
CitationsScopus - 3Web of Science - 3
Co-authorsJanet Holt, John Aitken, Eileen Mclaughlin
2006Aitken RJ, Skakkebaek NE, Roman SD, 'Male reproductive health and the environment (Editorial)', Medical Journal of Australia, 185 414-415 (2006) [C3]
CitationsScopus - 14Web of Science - 14
Co-authorsJohn Aitken
2006Holt JE, Jackson A, Roman SD, Aitken RJ, Koopman PA, McLaughlin EA, 'CXCR4/SDF1 interaction inhibits the primordial to primary follicle transition in the neonatal mouse ovary', Developmental Biology, 293 449-460 (2006) [C1]
DOI10.1016/j.ydbio.2006.02.012
CitationsScopus - 47Web of Science - 44
Co-authorsJohn Aitken, Janet Holt, Eileen Mclaughlin
2006Prabhu SM, Meistrich ML, McLaughlin EA, Roman SD, Warne S, Mendis S, et al., 'Expression of c-Kit receptor mRNA and protein in the developing, adult and irradiated rodent testis', Reproduction, 131 489-499 (2006) [C1]
DOI10.1530/rep.1.00968
CitationsScopus - 34Web of Science - 37
Co-authorsEileen Mclaughlin
2005Roman SD, Baleato RM, Aitken RJ, 'Interaction between BMP4 and retinoid signaling in mouse spermatogenesis', MECHANISMS OF DEVELOPMENT, 122 S126-S126 (2005)
Author URL
Co-authorsJohn Aitken
2004Baker MA, Hetherington L, Ecroyd HW, Roman SD, Aitken RJ, 'Analysis of the mechanism by which calcium negatively regulates the tyrosine phoshorylation cascade associated with sperm capacitation', Journal of Cell Science, 117 211-222 (2004) [C1]
DOI10.1242/jcs.00842
Co-authorsJohn Aitken, Mark Baker
2004Curry BJ, Roman SD, Wallace C, Scott RJ, Miriami E, Aitken RJ, 'Identification and characterisation of a novel splice variant of mouse and rat cytochrome b5/cytochrome b5 reductase', Genomics, 83 425-438 (2004) [C1]
DOI10.1016/j.ygeno.2003.08.020
CitationsScopus - 5Web of Science - 5
Co-authorsJohn Aitken, Ben Curry
2003Sutton KA, Roman SD, 'Progesterone Responses in Human Spermatozoa', Chemtracts-Biochemistry and Molecular Biology, 183-187 (2003) [C2]
CitationsScopus - 1
2003Wade MA, Roman SD, Jones RC, Aitken RJ, 'Adenylyl cyclase isoforms in rat testis and spermatozoa from the cauda epididymidis', Cell and Tissue Research, 314 411-419 (2003) [C1]
DOI10.1007/s00441-003-0801-6
CitationsScopus - 16Web of Science - 16
Co-authorsJohn Aitken
2001Sawyer DE, Roman SD, Aitken RJ, 'Relative susceptibilities of mitochondrial and nuclear DNA to damage induced by hydrogen peroxide in two mouse germ cell lines', Redox Report, 6 No. 3 182-184 (2001) [C1]
DOI10.1179/135100001101536157
CitationsScopus - 31Web of Science - 33
Co-authorsJohn Aitken
1999Lane MA, Chen AC, Roman SD, Derguini F, Gudas LJ, 'Removal of LIF (leukemia inhibitory factor) results in increased vitamin A (retinol) metabolism to 4-oxoretinol in embryonic stem cells', Proceedings of the National Academy of Sciences of the United States of America, 96 13524-13529 (1999)

Retinoids, vitamin A (retinol) and its metabolic derivatives, are required for normal vertebrate development. In murine embryonic stem (ES) cells, which remain undifferentiated wh... [more]

Retinoids, vitamin A (retinol) and its metabolic derivatives, are required for normal vertebrate development. In murine embryonic stem (ES) cells, which remain undifferentiated when cultured in the presence of LIF (leukemia inhibitory factor), little metabolism of exogenously added retinol takes place. After LIF removal, ES cells metabolize exogenously added retinol to 4-hydroxyretinol and 4-oxoretinol and concomitantly differentiate. The conversion of retinol to 4-oxoretinol is a high-capacity reaction because most of the exogenous retinol is metabolized rapidly, even when cells are exposed to physiological (¿1 µM) concentrations of retinol in the medium. No retinoic acid or 4-oxoRA synthesis from retinol was detected in ES cells cultured with or without LIF. The cytochrome P450 enzyme CYP26 (retinoic acid hydroxylase) is responsible for the metabolism of retinol to 4-oxoretinol, and CYP26 mRNA is greatly induced (>15-fold) after LIF removal. Concomitant with the expression of CYP26, differentiating ES cells grown in the absence of LIF activate the expression of the differentiation marker gene FGF-5 whereas the expression of the stem cell marker gene FGF-4 decreases. The strong correlation between the production of polar metabolites of retinol and the differentiation of ES cells upon removal of LIF suggests that one important action of LIF in these cells is to prevent retinol metabolism to biologically active, polar metabolites such as 4-oxoretinol.

DOI10.1073/pnas.96.23.13524
CitationsScopus - 48Web of Science - 49
1995Graham JD, Roman SD, McGowan E, Sutherland RL, Clarke CL, 'Preferential stimulation of human progesterone receptor B expression by estrogen in T-47D human breast cancer cells', JOURNAL OF BIOLOGICAL CHEMISTRY, 270 30693-30700 (1995)
Author URL
CitationsWeb of Science - 60
1993ROMAN SD, ORMANDY CJ, MANNING DL, BLAMEY RW, NICHOLSON RI, SUTHERLAND RL, CLARKE CL, 'ESTRADIOL INDUCTION OF RETINOIC ACID RECEPTORS IN HUMAN BREAST-CANCER CELLS', CANCER RESEARCH, 53 5940-5945 (1993)
Author URL
CitationsWeb of Science - 73
1992ROMAN SD, CLARKE CL, HALL RE, ALEXANDER IE, SUTHERLAND RL, 'EXPRESSION AND REGULATION OF RETINOIC ACID RECEPTORS IN HUMAN BREAST-CANCER CELLS', CANCER RESEARCH, 52 2236-2242 (1992)
Author URL
CitationsWeb of Science - 149
1991CLARKE CL, GRAHAM J, ROMAN SD, SUTHERLAND RL, 'DIRECT TRANSCRIPTIONAL REGULATION OF THE PROGESTERONE-RECEPTOR BY RETINOIC ACID DIMINISHES PROGESTIN RESPONSIVENESS IN THE BREAST-CANCER CELL-LINE T-47D', JOURNAL OF BIOLOGICAL CHEMISTRY, 266 18969-18975 (1991)
Author URL
CitationsWeb of Science - 46
1990CLARKE CL, ROMAN SD, GRAHAM J, KOGA M, SUTHERLAND RL, 'PROGESTERONE-RECEPTOR REGULATION BY RETINOIC ACID IN THE HUMAN BREAST-CANCER CELL-LINE T-47D', JOURNAL OF BIOLOGICAL CHEMISTRY, 265 12694-12700 (1990)
Author URL
CitationsWeb of Science - 59
Show 29 more journal articles

Conference (44 outputs)

YearCitationAltmetricsLink
2012Sobinoff AP, Beckett EL, Nixon B, Roman SD, Hansbro PM, McLaughlin EA, 'The impact of maternal cigarette smoke exposure on the male germline', Abstracts. The Annual Scientific Meeting of the Endocrine Society of Australia and the Society for Reproductive Biology 2012, Gold Coast, QLD (2012) [E3]
Co-authorsBrett Nixon, Eileen Mclaughlin, Philip Hansbro
2012Nixon BJ, Katen AL, Stanger SJ, Nixon B, Roman SD, 'Identifying biomarkers of chronic acrylamide exposure in the male germ line', Abstracts. The Annual Scientific Meeting of the Endocrine Society of Australia and the Society for Reproductive Biology 2012, Gold Coast, QLD (2012) [E3]
Co-authorsBrett Nixon
2010Fraser BA, Sobinoff AP, Pye VJ, Roman SD, Hime GR, Siddall NA, et al., 'Targets of RNA-binding protein Musashi-1 in mouse germ cell development', OzBio 2010: The Molecules of Life - from Discovery to Biotechnology. Poster Abstracts, Melbourne, Australia (2010) [E3]
Co-authorsEileen Mclaughlin
2010McIver SC, Roman SD, Nixon B, McLaughlin EA, 'MicroRNA signalling in early male germ cells', OzBio 2010: The Molecules of Life - from Discovery to Biotechnology. Poster Abstracts, Melbourne, Vic (2010) [E3]
Co-authorsBrett Nixon, Eileen Mclaughlin
2010Nixon BJ, Nixon B, Roman SD, 'The effect of acrylamide exposure on early male germ cells', OzBio 2010: The Molecules of Life - from Discovery to Biotechnology. Poster Abstracts, Melbourne, Vic (2010) [E3]
Co-authorsBrett Nixon
2010Pye VJ, Sobinoff AP, Nixon B, Roman SD, McLaughlin EA, 'Xenobiotics; influence on long term oocyte viability', OzBio 2010: The Molecules of Life - from Discovery to Biotechnology. Poster Abstracts, Melbourne, Vic (2010) [E3]
Co-authorsBrett Nixon, Eileen Mclaughlin
2010Reid AT, McEwan K, Campbell DM, Jans DA, Roman SD, 'Consistent nucleosome retention during chromatin packaging in human spermatozoa', OzBio 2010: The Molecules of Life - from Discovery to Biotechnology. Poster Abstracts, Melbourne, Vic (2010) [E3]
2010Reid AT, Roman SD, Aitken RJ, Nixon B, 'Investigation of the role of dynamin in sperm surface remodelling', OzBio 2010: The Molecules of Life - from Discovery to Biotechnology. Poster Abstracts, Melbourne, Vic (2010) [E3]
Co-authorsJohn Aitken, Brett Nixon
2010Sobinoff AP, Pye VJ, Nixon B, Roman SD, McLaughlin EA, 'Consistent mechanism of primordial follicle activation in neonatal mouse ovotoxicity', OzBio 2010: The Molecules of Life - from Discovery to Biotechnology. Poster Abstracts, Melbourne, Vic (2010) [E3]
Co-authorsBrett Nixon, Eileen Mclaughlin
2010Roman SD, Reid AT, McEwan K, Campbell DM, Jans DA, 'Nucleosome Retention During Chromatin Packaging in Spermatozoa', Reproduction, Fertility and Development, Sydney (2010) [E3]
2010Sobinoff AP, Pye VJ, Nixon B, Roman SD, McLaughlin EA, 'Short Term Xenobiotic Exposure Compromises Long Term Oocyte Viability', Reproduction, Fertility and Development, Sydney (2010) [E3]
Co-authorsBrett Nixon, Eileen Mclaughlin
2010McIver SC, Roman SD, Nixon B, McLaughlin EA, 'Microrna and Early Male Germ Cells', Reproduction, Fertility and Development, Sydney (2010) [E3]
Co-authorsEileen Mclaughlin, Brett Nixon
2010Nixon BJ, Nixon B, Roman SD, 'The Consequences of Acrylamide Exposure on the Male Germline', Reproduction, Fertility and Development, Sydney (2010) [E3]
Co-authorsBrett Nixon
2010Tannock SJ, McLaughlin EA, Aitken RJ, Roman SD, 'SPIF - A Novel Testis-Specific Gene and its Interaction with PKA', Reproduction, Fertility and Development, Sydney (2010) [E3]
Co-authorsEileen Mclaughlin, John Aitken
2010Reid AT, Roman SD, Aitken RJ, Nixon B, 'Characterisation of the GTPASE dynamin throughout murine sperm maturation', Reproduction, Fertility and Development, Sydney, NSW (2010) [E3]
Co-authorsJohn Aitken, Brett Nixon
2009Campbell DM, Roman SD, 'Chromatin packaging in human spermatozoa', Chromatin: Histones, Nucleosomes, Chromosomes & Genomes: Program & Abstract Book, Singapore (2009) [E3]
2009Roman SD, Stanger SJ, Borg Z, Low JL, McClymont SL, McLaughlin EA, 'Characterisation of spermatogonial stem cells', Regulatory Networks in Stem Cells: Program & Abstract Book, Singapore (2009) [E3]
Co-authorsEileen Mclaughlin
2008Fraser BA, Sobinoff A, Hime G, Siddall N, Roman SD, McLaughlin EA, 'The role of the RNA-binding protein, Musashi-1 in murine spermatogonial stem cell maintenance', Proceedings of 41st Annual Meeting of the Society for the Study of Reproduction., Kailua-Kona, Hawaii (2008) [E3]
Co-authorsEileen Mclaughlin
2008McLaughlin EA, Gunter KM, Woollett K, Roman SD, 'Chemokines: Role in germ cell migration and survival', Proceedings of 41st Annual Meeting of the Society for the Study of Reproduction. "Reproductive Biology: Basic Discoveries that Affect Our Lives", Kailua-Kona, Hawaii (2008) [E3]
Co-authorsEileen Mclaughlin
2008Aitken RJ, De Iuliis GN, Nixon B, Roman SD, 'Causes and clinical significance of DNA damage in the male germ line', Proceedings of 41st Annual Meeting of the Society for the Study of Reproduction. "Reproductive Biology: Basic Discoveries that Affect Our Lives", Kailua-Kona, Hawaii (2008) [E3]
Co-authorsJohn Aitken, Geoffry DeiuliIs, Brett Nixon
2008Aitken R, Do Iuliis G, Nixon B, Roman S, 'Causes and clinical significance of DNA damage in the male germ line', BIOLOGY OF REPRODUCTION, Kona, HI (2008) [E3]
Author URL
Co-authorsBrett Nixon, John Aitken
2008Roman SD, Nixon BJ, Stanger SJ, Schjenken JE, 'Expression and activity of phase I detoxifying enzymes in the male germ line of the mouse', Biology of Reproduction, Kailua-Kona, Hawaii (2008) [E3]
2007Gunter KM, Fraser BA, Holt JE, Stanger SJ, Aitken RJ, Roman SD, McLaughlin EA, 'CXCR4/SDF1 interaction in the neonatal mouse testes', 7th Hunter Cellular Biology Meeting. Program, Hunter Valley, NSW (2007) [E3]
Co-authorsEileen Mclaughlin, John Aitken, Janet Holt
2007Schjenken JE, Stanger SJ, Smith V, Douglas A, De Iuliis GN, Depaz I, et al., 'Expression and activity of phase 1 detoxifying enzymes in the male sperm line of the mouse', 7th Hunter Cellular Biology Meeting. Program, Hunter Valley, NSW (2007) [E3]
Co-authorsBrett Nixon, Geoffry DeiuliIs, John Aitken
2007Campbell DM, Roman SD, 'Use of chromatin immunoprecipitation (CHIP) on the genomes of human spermatozoa', Combined Conference Abstracts - ComBio 2007 Conference, Sydney (2007) [E3]
2007Roman SD, 'Expression and activity of phase 1 detoxifying enzymes in the male germ line of the mouse', Proceedings of the Thirty-Eighth Annual Conference Society for Reproductive Biology, Christchurch, New Zealand (2007) [E3]
2007Roman SD, Stanger SJ, Fraser BA, Borg Z, Low JL, McClymont SL, McLaughlin EA, 'Isolating and genotyping spermatogonial stem cells', Proceedings of the Thirty-Eighth Annual Conference Society for Reproductive Biology, Christchurch, New Zealand (2007) [E3]
Co-authorsEileen Mclaughlin
2006Fraser BA, Holt JE, Andrew J, Roman SD, Stanger SJ, Aitken RJ, et al., 'CXCR4/SDF1 Interactionin the Embryonic and Neonatal Mpise Testes', Abstracts, Brisbane Convention Centre, QLD, Australia (2006) [E3]
Co-authorsEileen Mclaughlin, Janet Holt, John Aitken
2006McLaughlin EA, Dorey RA, Roman SD, Aitken RJ, 'Xenobiotis and Fertility: Expression Profiling of Defence Mechanisms Present in Murine Ovary', Abstract Book, Lorne, VIC, Australia (2006) [E3]
Co-authorsJohn Aitken, Eileen Mclaughlin
2006Schjenken JE, Gilliam E, Borg Z, Aitken RJ, McLaughlin EA, Roman SD, 'Cytocrome P450 2E2 Mediates Acrylamide Damage to the Male Germ Line', Abstract Book, Lorne, VIC, Australia (2006) [E3]
Co-authorsJohn Aitken, Eileen Mclaughlin
2006Holt JE, Andrew J, Roman SD, Stanger SJ, Aitken RJ, Peter K, McLaughlin EA, 'CXCR4/SDF-1 interaction in the embryonic and neonatal mouse tests', Book of Abstracts, Chicago, Illinois (2006) [E3]
Co-authorsJohn Aitken, Janet Holt, Eileen Mclaughlin
2005Holt JE, Aitken RJ, Roman SD, McLaughlin E, 'Use of RNA interference for the functional analysis of genes involved in ovarian development', MECHANISMS OF DEVELOPMENT (2005) [E3]
Author URL
Co-authorsEileen Mclaughlin, Janet Holt, John Aitken
2005Hime G, Marriner N, McLaughlin E, Roman S, Loveland K, Siddall N, 'The RNA-binding protein musashi is required for stem cell maintenance in the Drosophila testis', MECHANISMS OF DEVELOPMENT (2005) [E3]
Author URL
Co-authorsEileen Mclaughlin
2004Holt JE, Aitken RJ, Roman SD, McLaughlin EA, 'Expression of the Chemokine CXCL12 and its receptor CXCR4 in the activating Mammalian Ovarian follicle', Reproduction, Fertility and Development, Sydney (2004) [E3]
Co-authorsJanet Holt, John Aitken, Eileen Mclaughlin
2004Baleato R, Aitken RJ, Roman SD, 'Interaction between bone morphogenetic protein 4 and retinoid signalling in mouse spermatogenesis', Reproduction, Fettility and Development, Darling Harbour, NSW, Australia (2004) [E3]
Co-authorsJohn Aitken
2004Roman SD, McLaughlin EA, 'Peer pressure and performance: meaningful team work', Proceedings of Scholarly Inquiry into Science Teaching and Leaning, University of Sydney (2004) [E3]
Co-authorsEileen Mclaughlin
2003Holt JE, Aitken RJ, Roman SD, McLaughlin EA, 'Gene expression in the activating mammalian ovarian follicle', ComBio Combined Conference Abstracts, Melbourne (2003) [E3]
Co-authorsJohn Aitken, Eileen Mclaughlin, Janet Holt
2003Baker MA, Hetherington L, Ecroyd HW, Roman SD, Aitken RJ, 'Analysis of the mechanism by which calcium negatively regulates the tyrosine phosphorylation cascade associated with sperm capacitation', ComBio Combined Conference Abstracts, Melbourne (2003) [E3]
CitationsScopus - 63Web of Science - 56
Co-authorsJohn Aitken, Mark Baker
2003Baleato R, Aitken RJ, Roman SD, 'Regulation of gene expression in mouse germ cells by retinoids', ComBio Combined Conference Abstracts, Melbourne (2003) [E3]
Co-authorsJohn Aitken
2003Roman SD, Baleato R, Aitken RJ, 'Retinoid responsiveness of the murine spermatogonial cell line GC-1', Functional Genomics of Male Reproductions, Phoenix, Arizona (2003) [E3]
Co-authorsJohn Aitken
2003Wade MA, Roman SD, Jones RC, Aitken RJ, 'Gene Expression of Adenylyl Cyclase in Rat Testis', The Third International Conference on the Epididymis, Charlottesville, Virginia (2003) [E3]
Co-authorsJohn Aitken
2002Wade MA, Roman SD, Jones RC, Aitken RJ, 'Gene expression of adenylyl cyclase in rat testis and caudal epididymal sperm', Reproduction, Fertility and Development, Adelaide, SA (2002) [E3]
Co-authorsJohn Aitken
2002Baleato R, Aitken RJ, Roman SD, 'Retinoid Responsiveness of Adult Murine Germ Cells', Proceedings of the Australian Society for Biochemistry and Molecular Biology, Sydney, NSW (2002) [E3]
Co-authorsJohn Aitken
2002Sutton KA, Wallace C, Aitken RJ, Roman SD, 'Identifying markers of the mammalian male germ line using subtractive hybridisation', Proceedings of the Australian Society for Biochemistry and Molecular Biology, Sydney, NSW (2002) [E3]
Co-authorsJohn Aitken
Show 41 more conferences
Edit

Grants and Funding

Summary

Number of grants39
Total funding$20,778,602

Click on a grant title below to expand the full details for that specific grant.


20141 grants / $10,000

Ameliorating the DNA damaging effects of acrylamide on the male germline.$10,000

Funding body: University of Newcastle - Faculty of Science & IT

Funding bodyUniversity of Newcastle - Faculty of Science & IT
Project TeamDoctor Shaun Roman
SchemeStrategic Initiative Research Fund (SIRF)
RoleLead
Funding Start2014
Funding Finish2014
GNoG1401044
Type Of FundingInternal
CategoryINTE
UONY

20132 grants / $26,000

NucleoCounter SP100$14,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamLaureate Professor John Aitken, Associate Professor Brett Nixon, Doctor Shaun Roman, Doctor Mark Baker, Doctor Geoffry De Iuliis, Doctor Lisa Mitchell, Doctor Matthew Jobling, Doctor Zamira Gibb, Mr Nenad Naumovski
SchemeEquipment Grant
RoleInvestigator
Funding Start2013
Funding Finish2013
GNoG1201175
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

Ameliorating male germline toxicology.$12,000

Funding body: University of Newcastle - Faculty of Science & IT

Funding bodyUniversity of Newcastle - Faculty of Science & IT
Project TeamDoctor Shaun Roman
SchemeStrategic Small Grant
RoleLead
Funding Start2013
Funding Finish2013
GNoG1401070
Type Of FundingInternal
CategoryINTE
UONY

20123 grants / $37,000

BMG SPECTROstar Nano$15,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamLaureate Professor John Aitken, Professor Eileen McLaughlin, Ms Belinda Nixon, Doctor Shaun Roman, Doctor Mark Baker, Doctor Geoffry De Iuliis, Doctor Lisa Mitchell, Doctor Matthew Jobling
SchemeEquipment Grant
RoleInvestigator
Funding Start2012
Funding Finish2012
GNoG1100971
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

Developing a model to assess the effects of chronic chemical exposure on the male germ line$12,000

Funding body: University of Newcastle - Faculty of Science & IT

Funding bodyUniversity of Newcastle - Faculty of Science & IT
Project TeamDoctor Shaun Roman
SchemeStrategic Small Grant
RoleLead
Funding Start2012
Funding Finish2012
GNoG1401104
Type Of FundingInternal
CategoryINTE
UONY

Ultrasonic Homogenizer System and -80 ºC Freezers for chemical and biological sample storage$10,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Adam McCluskey, Professor Eileen McLaughlin, Professor Peter Lewis, Ms Belinda Nixon, Doctor Shaun Roman, Doctor Jennette Sakoff, Doctor Ian Grainge
SchemeEquipment Grant
RoleInvestigator
Funding Start2012
Funding Finish2012
GNoG1100986
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

20112 grants / $459,961

Chemical Biology$444,961

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Adam McCluskey, Doctor Warwick Belcher, Doctor Ian Grainge, Professor Christopher Grof, Professor Peter Lewis, Professor Eileen McLaughlin, Doctor Shaun Roman, Conjoint Professor Ray Rose, Doctor Jennette Sakoff, Doctor Nikki Verrills
SchemePriority Research Centre
RoleInvestigator
Funding Start2011
Funding Finish2011
GNoG1100052
Type Of FundingInternal
CategoryINTE
UONY

Eppendorf mastercycler pro with thermomixer comfort and 5430R centrifuge$15,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Eileen McLaughlin, Professor Peter Lewis, Professor Adam McCluskey, Conjoint Professor Keith Jones, Associate Professor Brett Nixon, Doctor Shaun Roman, Doctor Jennette Sakoff, Doctor Ian Grainge, Doctor Janet Holt, Doctor Xiao Yang
SchemeEquipment Grant
RoleInvestigator
Funding Start2011
Funding Finish2011
GNoG1100028
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

20106 grants / $2,061,472

Sex Ratio and Sterility for Commercial animal production - round 5 Cluster$700,000

Funding body: CSIRO - Commonwealth Scientific and Industrial Research Organisation

Funding bodyCSIRO - Commonwealth Scientific and Industrial Research Organisation
Project TeamLaureate Professor John Aitken, Professor Eileen McLaughlin, Doctor Shaun Roman
SchemeNational Research Flagship Cluster
RoleInvestigator
Funding Start2010
Funding Finish2010
GNoG1000045
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

An Integrated LC-MS-NMR facility for Applications in Proteomics and Organic Chemistry$500,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamProfessor Adam McCluskey, Laureate Professor John Aitken, Professor Paul Dastoor, Professor Phillip Robinson, Professor Eileen McLaughlin, Emeritus Professor Geoffrey Lawrance, Professor Marcel Maeder, Professor Hugh Dunstan, Doctor Shaun Roman, Professor Rob Atkin, Doctor Clovia Holdsworth, Doctor Mark Baker, Doctor Nikki Verrills, Professor Gottfried Otting, Associate Professor Brett Nixon, Doctor Xiaojing Zhou, Ms Megan Chircop, Doctor Warwick Belcher
SchemeLinkage Infrastructure Equipment & Facilities (LIEF)
RoleInvestigator
Funding Start2010
Funding Finish2010
GNoG0190402
Type Of FundingScheme excluded from IGS
CategoryEXCL
UONY

An Integrated LC-MS-NMR facility for Applications in Proteomics and Organic Chemistry$280,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Adam McCluskey, Laureate Professor John Aitken, Professor Paul Dastoor, Professor Phillip Robinson, Professor Eileen McLaughlin, Emeritus Professor Geoffrey Lawrance, Professor Marcel Maeder, Professor Hugh Dunstan, Doctor Shaun Roman, Professor Rob Atkin, Doctor Clovia Holdsworth, Doctor Mark Baker, Doctor Nikki Verrills, Professor Gottfried Otting, Associate Professor Brett Nixon, Doctor Xiaojing Zhou, Ms Megan Chircop, Doctor Warwick Belcher
SchemeEquipment Grant
RoleInvestigator
Funding Start2010
Funding Finish2010
GNoG1000873
Type Of FundingInternal
CategoryINTE
UONY

Identifying vulnerable sites in the male genome$16,472

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Shaun Roman
SchemeProject Grant
RoleLead
Funding Start2010
Funding Finish2010
GNoG0900133
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

20094 grants / $845,000

Confocal Laser Scanning Microscopy for Live Cell Imaging$275,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamConjoint Professor Keith Jones, Professor Eileen McLaughlin, Laureate Professor John Aitken, Conjoint Professor Ray Rose, Emeritus Professor John Patrick, Conjoint Professor Christina Offler, Associate Professor David McCurdy, Emeritus Professor Leonie Ashman, Professor Gordon Burns, Professor Dirk Van Helden, Doctor Nikki Verrills, Associate Professor Brett Nixon, Doctor Shaun Roman, Associate Professor Yong-Ling Ruan, Doctor Rick Thorne, Professor Mike Calford
SchemeLinkage Infrastructure Equipment & Facilities (LIEF)
RoleInvestigator
Funding Start2009
Funding Finish2009
GNoG0189038
Type Of FundingScheme excluded from IGS
CategoryEXCL
UONY

LAS-4000 Chemiluminescence imaging system$25,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Eileen McLaughlin, Laureate Professor John Aitken, Professor Peter Lewis, Associate Professor Brett Nixon, Doctor Shaun Roman
SchemeEquipment Grant
RoleInvestigator
Funding Start2009
Funding Finish2009
GNoG0189852
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

20083 grants / $7,079,898

Centre for Biotechnology and Development$6,420,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamLaureate Professor John Aitken, Dr Gary Hime, Professor M Holland, Professor D Jans, Professor P Koopman, Dr Kate Loveland, Professor Eileen McLaughlin, Dr M O'Bryan, Doctor Shaun Roman, Assoc. Prof A Sinclair
SchemeARC Centres of Excellence
RoleInvestigator
Funding Start2008
Funding Finish2008
GNoG0188624
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Xenobiotics - ocidative stress in the mammalian ovary$362,625

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Eileen McLaughlin, Associate Professor Brett Nixon, Doctor Shaun Roman
SchemeProject Grant
RoleInvestigator
Funding Start2008
Funding Finish2008
GNoG0187620
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Centre for Biotechnology and Development$297,273

Funding body: NSW Department of State and Regional Development

Funding bodyNSW Department of State and Regional Development
Project TeamLaureate Professor John Aitken, Dr Gary Hime, Professor M Holland, Professor D Jans, Professor P Koopman, Dr Kate Loveland, Professor Eileen McLaughlin, Dr M O'Bryan, Doctor Shaun Roman, Assoc. Prof A Sinclair
SchemeCentres of Excellence (Partner)
RoleInvestigator
Funding Start2008
Funding Finish2008
GNoG0189183
Type Of FundingOther Public Sector - State
Category2OPS
UONY

20073 grants / $117,920

Centre for Biotechnology and Development.$96,220

Funding body: NSW Department of State and Regional Development

Funding bodyNSW Department of State and Regional Development
Project TeamLaureate Professor John Aitken, Dr Kate Loveland, Professor P Koopman, Assoc. Prof A Sinclair, Professor D De Krester, Dr M O'Bryan, Dr Gary Hime, Professor D Jans, Doctor Shaun Roman, Professor Eileen McLaughlin, Professor C Goodnow, Professor M Holland
SchemeCentres of Excellence (Partner)
RoleInvestigator
Funding Start2007
Funding Finish2007
GNoG0187937
Type Of FundingOther Public Sector - State
Category2OPS
UONY

Chemokines and spermatogenesis: roles of SDF-1 and CXCR-4 in the establishment of spermatogenesis$20,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Eileen McLaughlin, Doctor Shaun Roman, Associate Professor Brett Nixon
SchemeNear Miss Grant
RoleInvestigator
Funding Start2007
Funding Finish2007
GNoG0187197
Type Of FundingInternal
CategoryINTE
UONY

Annual Scientific Meeting of the Society for Reproductive Biology, Christchurch NZ, 2/9/2007 - 5/9/2007$1,700

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Shaun Roman
SchemeTravel Grant
RoleLead
Funding Start2007
Funding Finish2007
GNoG0188087
Type Of FundingInternal
CategoryINTE
UONY

20063 grants / $571,555

PRC - Priority Research Centre for Reproductive Science$544,282

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamLaureate Professor John Aitken, Professor Roger Smith, Professor Eileen McLaughlin, Associate Professor Brett Nixon, Doctor Shaun Roman, Conjoint Associate Professor Vicki Clifton, Conjoint Professor Warwick Giles, Professor Jon Hirst, Conjoint Associate Professor Rick Nicholson, Professor Ian Symonds
SchemePriority Research Centre
RoleInvestigator
Funding Start2006
Funding Finish2006
GNoG0186945
Type Of FundingInternal
CategoryINTE
UONY

Environmental impacts on female fertility and the menopause$17,273

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamProfessor Eileen McLaughlin, Laureate Professor John Aitken, Doctor Shaun Roman
SchemeResearch Grant
RoleInvestigator
Funding Start2006
Funding Finish2006
GNoG0186620
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Elucidating the mechanics of transgenerational toxicity in the ageing male$10,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Shaun Roman, Professor John Attia, Dr Elizabeth Gillam
SchemeNear Miss Grant
RoleLead
Funding Start2006
Funding Finish2006
GNoG0186080
Type Of FundingInternal
CategoryINTE
UONY

20051 grants / $15,000

Gene profiling of the detoxifying enzymes in the male germ line$15,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Shaun Roman, Laureate Professor John Aitken
SchemeProject Grant
RoleLead
Funding Start2005
Funding Finish2005
GNoG0184897
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

20041 grants / $8,000

In vivo regulation of spermatogonial gene expression by Vitamin A$8,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Shaun Roman, Laureate Professor John Aitken
SchemeProject Grant
RoleLead
Funding Start2004
Funding Finish2004
GNoG0183416
Type Of FundingInternal
CategoryINTE
UONY

20034 grants / $9,495,296

Centre for Biotechnology and Development.$9,458,900

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamLaureate Professor John Aitken, Dr Kate Loveland, Professor P Koopman, Assoc. Prof A Sinclair, Professor D De Krester, Dr M O'Bryan, Dr Gary Hime, Professor D Jans, Doctor Shaun Roman, Professor Eileen McLaughlin, Professor C Goodnow, Professor M Holland
SchemeARC Centres of Excellence
RoleInvestigator
Funding Start2003
Funding Finish2003
GNoG0182214
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

The origin and control of oxidative stress in the placenta$29,666

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamLaureate Professor John Aitken, Professor Roger Smith, Doctor Shaun Roman
SchemeMulti-Year Project Grant Scholarship
RoleInvestigator
Funding Start2003
Funding Finish2003
GNoG0182393
Type Of FundingInternal
CategoryINTE
UONY

Profiling germ cell gene expression during spermatogonial differentiation$5,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Shaun Roman, Professor Eileen McLaughlin
SchemeProject Grant
RoleLead
Funding Start2003
Funding Finish2003
GNoG0182402
Type Of FundingInternal
CategoryINTE
UONY

American Society of Andrology annual Meeting and associated workshops, Phoenix, Arizona, USA 26 March - 2 April, 2003$1,730

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Shaun Roman
SchemeTravel Grant
RoleLead
Funding Start2003
Funding Finish2003
GNoG0182915
Type Of FundingInternal
CategoryINTE
UONY

20022 grants / $13,000

Regulation of gene expression during spermatogonial development$8,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Shaun Roman
SchemeProject Grant
RoleLead
Funding Start2002
Funding Finish2002
GNoG0181441
Type Of FundingInternal
CategoryINTE
UONY

Characterisation of a non-genomic progesterone receptor in round spermatids$5,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Shaun Roman, Laureate Professor John Aitken
SchemeProject Grant
RoleLead
Funding Start2002
Funding Finish2002
GNoG0181445
Type Of FundingInternal
CategoryINTE
UONY

20011 grants / $8,500

Interaction of Smad and Retinoid signalling pathways.$8,500

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Shaun Roman
SchemeProject Grant
RoleLead
Funding Start2001
Funding Finish2001
GNoG0180093
Type Of FundingInternal
CategoryINTE
UONY

20001 grants / $10,000

Molecular basis of spermatogenesis$10,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDr Keith Sutton, Laureate Professor John Aitken, Doctor Shaun Roman
SchemeProject Grant
RoleInvestigator
Funding Start2000
Funding Finish2000
GNoG0178860
Type Of FundingInternal
CategoryINTE
UONY

19992 grants / $20,000

Culture and genetic manipulation of male germ-line stem cells$11,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Shaun Roman
SchemeNew Staff Grant
RoleLead
Funding Start1999
Funding Finish1999
GNoG0178424
Type Of FundingInternal
CategoryINTE
UONY

Isolation of genetic markers to follow male germ cell progression from birth to spermatocyte.$9,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Shaun Roman
SchemeEarly Career Researcher Grant
RoleLead
Funding Start1999
Funding Finish1999
GNoG0179147
Type Of FundingInternal
CategoryINTE
UONY
Edit

Research Supervision

Current Supervision

CommencedResearch Title / Program / Supervisor Type
2013Genetic Consequences of Paternal Acrylamide Exposure and Potential for Amelioration
Biological Sciences, Faculty of Science and Information Technology
Principal Supervisor
2013Post-Meiotic Sperm DNA Damage and Consequences to Offspring
Biological Sciences, Faculty of Science and Information Technology
Co-Supervisor
2009The Influence of Peroxisomes on Reactive Oxygen Species Regulation and Regeneration Induction in Plants
Biological Sciences, Faculty of Science and Information Technology
Co-Supervisor
2007The role of SDF-1/CXCR4 in spermatogenesis
Biol Sc Not Elsewhere Classifd, University of Newcastle
Co-Supervisor

Past Supervision

YearResearch Title / Program / Supervisor Type
2015Functional Characterisation of Dynamin in Mouse Spermatozoa
Biological Sciences, Faculty of Science and Information Technology
Co-Supervisor
2014The Consequences of Acrylamide Exposure of the Male Germ Line
Biological Sciences, Faculty of Science and Information Technology
Principal Supervisor
2013Regulation of the Transition from Gonocytes to Spermatogonia
Biological Sciences, Faculty of Science and Information Technology
Co-Supervisor
2013Investigation of the Transcription Complex in Acinetobacter baylyi ADP1 and the Identification of the Novel Small Acidic Transcription Factor AtfA
Biological Sciences, Faculty of Science and Information Technology
Co-Supervisor
2012Xenobiotics; Effects on Female Fertility
Biological Sciences, Faculty of Science and Information Technology
Co-Supervisor
2009The Nature of Chromatin Packaging in Human Spermatozoa
Biological Sciences, Faculty of Science and Information Technology
Principal Supervisor
2006Gene Expression During Development of the Mammalian Ovarian Primordial Follicle
Biological Sciences, Faculty of Science and Information Technology
Co-Supervisor
2005Cytochrome P450 gene expression in the male germ line
Biol Sc Not Elsewhere Classifd, University of Newcastle
Sole Supervisor
2005The Regulation of Gene Expression by Vitamin A during Mouse Spermatogenesis
Biological Sciences, Faculty of Science and Information Technology
Sole Supervisor
2004SOCS expression in the ovary
Biol Sc Not Elsewhere Classifd, University of Newcastle
Co-Supervisor
2003Sperm Motility
Biol Sc Not Elsewhere Classifd, University of Newcastle
Co-Supervisor
2003Characterisation of the sperm progesterone receptor
Biol Sc Not Elsewhere Classifd, University of Newcastle
Co-Supervisor
2003DNA damage and chromatin packaging in human spermatozoa
Biol Sc Not Elsewhere Classifd, University of Newcastle
Co-Supervisor
2001TGF-b signalling
Biol Sc Not Elsewhere Classifd, University of Newcastle
Principal Supervisor
2000Foetal Organ Culture
Biol Sc Not Elsewhere Classifd, University of Newcastle
Co-Supervisor
2000Factors Regulating Spermatogenesis
Biol Sc Not Elsewhere Classifd, University of Newcastle
Co-Supervisor
2000Oxidases in Aradopsis
Biol Sc Not Elsewhere Classifd, University of Newcastle
Co-Supervisor
1999Oxidases in Wallaby Spermatozoa
Biol Sc Not Elsewhere Classifd, University of Newcastle
Co-Supervisor
1999Mammalian Sex Determination
Biol Sc Not Elsewhere Classifd, University of Newcastle
Co-Supervisor
Edit

Dr Shaun Roman

Position

Senior Lecturer
School of Environmental and Life Sciences
Faculty of Science and Information Technology

Focus area

Biological Sciences

Contact Details

Emailshaun.roman@newcastle.edu.au
Phone(02) 4921 6818
Fax(02) 4921 6923

Office

RoomLS4-37
BuildingLife Sciences
LocationCallaghan
University Drive
Callaghan, NSW 2308
Australia
Edit