Staff Profile

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Career Summary

Biography

Dr. Rick Thorne (PhD 1999) is a postdoctoral researcher sponsored by the HMRI Cancer Research Program and contracted lecturer in the School of Biomedical Sciences & Pharmacy at the University of Newcastle. His major interest involves different families of cell adhesion molecules and how these engage signalling pathways, particularly how these contribute to the development and progression of cancer. These interests overlap with CD36, another signalling molecule with disease functions outside cancer, particularly the metabolic syndrome and related disorders such as diabetes.

Dr. Thorne has over ten years postdoctoral experience beginning with the award of a two year competitive postdoctoral fellowship Brawn Postdoctoral Research Fellow undertaken at the UoN under Prof. Gordon Burns. During that period he was awarded two competitive overseas training schemes through the UICC, an International Cancer Technology Transfer Fellowships undertaken at the ICRF in London, UK (2000) and a Cancer Research Training Course held in Toronto, Canada (2001). Pursing further training he then relocated the UK to take up a three year post as a Postdoctoral Fellow in Training (2002-2004) at the 5* Institute of Cancer Research (ICR, London). This appointment also led to a number of quality publications and first-hand experience as a PhD supervisor and supervisor of graduate student projects for Imperial College (honours equivalent). Following the ICR appointment he returned to UoN under an ARC Australian Postdoctoral Fellowship awarded from 2004-2007 in connection with an ARC Discovery Project. Subsequent to this award he received a three year Cancer Institute NSW fellowship for the period 2008-2010. After a number of years acting as laboratory manager for the Cancer Research Unit, Dr. Thorne inherited the facilities’ of Prof. Burns and now runs this laboratory on an independent basis.

Over the last five years Dr. Thorne has contributed 27 original research articles and one review article. For ten of these publications he is the first, equal contributory or senior author. Within this body of work there is a strong indication of productive collaborations with local, national and international colleagues.

Qualifications

  • PhD, University of Newcastle, 27/08/1999
  • Bachelor of Science (Honours), University of Newcastle, 30/04/1988
  • Bachelor of Science, University of Newcastle, 02/05/1987

Research

Research keywords

  • apoptosis
  • cell adhesion
  • cell signaling

Research expertise

I have been working in laboratory-based science for nearly twenty years with direct hands on experience in vast array of techniques. I have a strong interest in the technical aspects of science, and have been instrumental in obtaining key equipment for my own research work and for the greater benefit of my research colleagues.

A summary of my technical skills and experience is as follows.

Molecular Biology: All DNA manipulations associated with the construction of expression vectors including epitope tagged molecules, fusion proteins, mutants and chimeras, recombinant adenoviruses. DNA and RNA preparation and analysis by southern and northern blotting, PCR, screening assays for cDNA libraries, yeast-2-hybrid assays etc.

Protein analysis and biochemistry: SDS-PAGE, 2D gels, immunoprecipitation, GST-pulldown, immunoblotting, use of radioisotopes, kinase assays, metabolic labeling studies, N-glycan analysis, chromatographic and related biochemical methods, flow cytometry, ELISA assays, protein and enzyme assays.

Imaging: I have developed and manage a microscope facility consisting of a trio of three Zeiss microscopes freely available to all subject to appropriate training. All utilise a common software package (Axiovision) that helps in training of users. I have a great deal of experience in immunofluorescence and confocal microscopic imaging.

The Axioplan 2 is a standard upright miscroscope equipped with colour and monochrome cameras, Apotome imaging device, Colibri 2 illumination system. This is powerful system fitted with a large number of epifluorescence filter sets and high performance objectives. This system is adaptable to almost any specimen on a slide.

The Axiovert 200 is a manual inverted fluorescence microscope fitted with a high resolution monochrome camera. Suitable for general work using cultured cells.

The Cell Observer System is for live cell imaging and more complex scanning tasks. It consists of an automated inverted microscope with scanning stage and an integrated incubator system.

Cell culture and in vitro assays: derivation and maintenance of cell lines, cryopreservation, mycoplasma screening, cell transfection methods, cloning and cell sorting, production and characterization of monoclonal antibodies, cell adhesion, migration and chemotaxis assays, drug toxicity, apoptosis, phagocytosis and cell-mediated immunity assays.

In vivo models: I have developed experimental models for cancer metastasis and immunoscintography in human xenograft models of melanoma, and experimental chemotherapy protocols for an rodent model of acquired drug-resistance in mammary cancer.

Fields of Research

CodeDescriptionPercentage
060100Biochemistry And Cell Biology40
110399Clinical Sciences Not Elsewhere Classified30
110199Medical Biochemistry And Metabolomics Not Elsewhere Classified30

Memberships

Committee/Associations (relevant to research).

  • Member - American Association of Cancer Research
  • Lifetime fellow of organisation - International Union against Cancer (UICC)

Appointments

Gladys M Brawn Memorial Fellowship
The University of Newcastle (Australia)
01/01/2000 - 01/04/2001

Awards

Research Award.

2007
UICC (Australia)
International award to undertake UICC Cancer Research Training Course: Molecular Biology of Solid Tumour Therapeutics. (2001) Sponsored travel and accommodation to Toronto, Ontario, Canada.

Invitations

Dr. A. Obaidat, Department of Pharmacy
Jordan University of Science and Technology, King Abdullah II Hospital, Jordan (Invitation to give lectures in Jordan to JUST and to the affiliated King Abdullah II Hospital)
2006

Administrative

Administrative expertise

Membership of the Steering committee of the HMRI Cancer Research Program (2005-current)

Organising committee member and session chairs for the HMRI Translational Cancer Conferences held in 2006 and 2008

Convener of the HMRI CRP seminar program from 2005-2009

HMRI Grant Review Panel Member 2009

Ad hoc representation on various committees at the School and Faculty level acting on behalf of Cancer Researchers and/or the discipline of Medical Biochemistry

Reviewer of project grant applications in Research Infrastructure Block Grant (RIBG) Scheme (2006)

Peer reviewer for both ARC Discovery and NHMRC Project grants since 2007

Peer reviewer for a number of scientific journals including Biochemical Journal, Journal of Lipid Research, Experimental Cell Research, Immunology and Cell Biology, Journal of Signal Transduction, Stem Cell Reviews & Reports and the British Journal of Cancer

Member of the NHMRC GRPs in 2011 and 2012 assessing grants for Cancer Biology & Oncology

Teaching

Teaching expertise

Research Higher Degree Completions

Mr. George Tzircotis (PhD 2005, University of London, UK) co-supervisor

Ms. Kristy Shipman (PhD 2009, University of Newcastle, Australia) co-supervisor

Mr. Mohammad Alkhatatbeh (thesis accepted December, 2012) primary supervisor

Current Research Higher Degree Students

As primary supervisor

Ms. Camila Oliveira (enrolment confirmed, thesis submission due November 2012)

Mr. Alireza Arjmand (enrolment confirmed, thesis submission due February 2012)

Ms. Elham Sadeqzadeh (enrolment confirmed, thesis submission due February 2012)

Mr. Abdulrzag Ahmed (enrolment confirmed, thesis submission due February 2014)

As co-supervisor

Ms. Jiao Li (other supervisors A/Prof. Derek Laver and A/Prof. Dirk Van Helden)

Additionally I have sat on a number of RHD confirmation panels for students from both the School of Biological Sciences and the School of Medicine and Public Health.

Honours (and equivalent) supervision

Ms. Ka Man Emily Chu (Final Year Project, Imperial College London, 2003)

Ms. Dale Anne Boyce (Honours, Bachelor of Biomedical Sciences, University of Newcastle, 2005)

Mr. Andrew James William Weir (Honours, Bachelor of Biomedical Sciences, University of Newcastle, 2007)

Mr. Simon Bone (Honours, Bachelor of Biomedical Sciences, University of Newcastle, 2007)

Mr. Steven Alley (Honours, Bachelor of Biomedical Sciences, University of Newcastle, 2009)

Mr. Tim Kelso (Honours, Bachelor of Biomedical Sciences, University of Newcastle, 2010)

Ms. Anna Timofeeva (Final Year Project, Karolinska Institute, Sweden, 2011)

Undergraduate Teaching experience

Contracted 0.5 lecturing appointment for undergraduate teaching in the School of Biomedical Sciences Bachelor’s program in 2001 and 2012 where I lectured major components of HUBS 2206 (Human Biochemistry and Cell Biology), HUBS 2209 (Human Molecular Science) and supervised associated Laboratory Practical Classes

Course coordinator of HUBS 3409 (Project in Biomedical Sciences) in 2011 and 2012

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Highlighted Publications

For publications that are currently unpublished or in-press, details are shown in italics.

YearCitationAltmetricsLink
2006Tzircotis G, Thorne RF, Isacke CM, 'Directional sensing of a phorbol ester gradient requires CD44 and is regulated by CD44 phosphorylation', Oncogene, 25 7401-7410 (2006) [C1]
2005Tzircotis G, Thorne RF, Isacke CM, 'Chemotaxis towards hyaluronan is dependent on CD44 expression and modulated by cell type variation in CD44-hyaluronan binding', Journal of Cell Science, 118 5119-5128 (2005) [C1]

Publications

For publications that are currently unpublished or in-press, details are shown in italics.

Click on a category title below to expand the list of citations for that specific category.

Journal article (62 outputs)

YearCitationAltmetricsLink
2014Mhaidat NM, Bouklihacene M, Thorne RF, '5-Fluorouracil-induced apoptosis in colorectal cancer cells is caspase-9-dependent and mediated by activation of protein kinase C-d', Oncology Letters, 8 699-704 (2014) [C1]
2014Wojtalewicz N, Sadeqzadeh E, Weiss JV, Tehrani MM, Klein-Scory S, Hahn S, et al., 'A Soluble Form of the Giant Cadherin Fat1 Is Released from Pancreatic Cancer Cells by ADAM10 Mediated Ectodomain Shedding', PLOS ONE, 9 (2014) [C1]
2014Oliveira CS, de Bock CE, Molloy TJ, Sadeqzadeh E, Geng XY, Hersey P, et al., 'Macrophage migration inhibitory factor engages PI3K/Akt signalling and is a prognostic factor in metastatic melanoma.', BMC Cancer, 14 630 (2014)
2014Sadeqzadeh E, de Bock CE, Thorne RF, 'Sleeping Giants: Emerging Roles for the Fat Cadherins in Health and Disease', MEDICINAL RESEARCH REVIEWS, 34 190-221 (2014)
2014Sadeqzadeh E, de Bock CE, Wojtalewicz N, Holt JE, Smith ND, Dun MD, et al., 'Furin processing dictates ectodomain shedding of human FAT1 cadherin.', Exp Cell Res, 323 41-55 (2014)
2014Sadeqzadeh E, De Bock CE, Wojtalewicz N, Holt JE, Smith ND, Dun MD, et al., 'Furin processing dictates ectodomain shedding of human FAT1 cadherin', Experimental Cell Research, 323 41-55 (2014)
2014Sadeqzadeh E, De Bock CE, Thorne RF, 'Sleeping Giants: Emerging Roles for the Fat Cadherins in Health and Disease', Medicinal Research Reviews, 34 190-221 (2014)
2014Sadeqzadeh E, de Bock CE, O'Donnell MR, Timofeeva A, Burns GF, Thorne RF, 'FAT1 cadherin is multiply phosphorylated on its ectodomain but phosphorylation is not catalysed by the four-jointed homologue.', FEBS Lett, 588 3511-3517 (2014)
2013Ye Y, Jin L, Wilmott JS, Hu WL, Yosufi B, Thorne RF, et al., 'PI(4,5)P2 5-phosphatase A regulates PI3K/Akt signalling and has a tumour suppressive role in human melanoma', NATURE COMMUNICATIONS, 4 (2013) [C1]
2013Ardjmand A, de Bock CE, Shahrokhi S, Lincz LF, Boyd AW, Burns GF, Thorne RF, 'Fat1 cadherin provides a novel minimal residual disease marker in acute lymphoblastic leukemia', HEMATOLOGY, 18 315-321 (2013) [C1]
2013Alkhatatbeh MJ, Enjeti AK, Acharya S, Thorne RF, Lincz LF, 'The origin of circulating CD36 in type 2 diabetes', NUTRITION & DIABETES, 3 (2013) [C1]
2013Li J, Imtiaz MS, Beard NA, Dulhunty AF, Thorne R, vanHelden DF, Laver DR, 'ß-Adrenergic stimulation increases RyR2 activity via intracellular Ca2+ and Mg2+ regulation.', PLoS One, 8 e58334 (2013) [C1]
2013Guo ST, Jiang CC, Wang GP, Li YP, Wang CY, Guo XY, et al., 'MicroRNA-497 targets insulin-like growth factor 1 receptor and has a tumour suppressive role in human colorectal cancer', ONCOGENE, 32 1910-1920 (2013) [C1]
2013Mhaidat NM, Qandil AM, Al-Balas QA, Hassan MA, Jaradat SA, Matalkah AM, Thorne RT, 'Methoxyphenylcipro induces antitumor activity in human cancer cells', Archives of Pharmacal Research, 36 1023-1028 (2013) [C1]
2012Tay KH, Jin L, Tseng HY, Jiang CC, Ye Y, Thorne RF, et al., 'Suppression of PP2A is critical for protection of melanoma cells upon endoplasmic reticulum stress', Cell Death and Disease, 3 e337 (2012) [C1]
2012De Bock CE, Ardjmand Ghahestani A, Molloy TJ, Bone SM, Johnstone DM, Campbell DM, et al., 'The Fat1 cadherin is overexpressed and an independent prognostic factor for survival in paired diagnosis-relapse samples of precursor B-cell acute lymphoblastic leukemia', Leukemia, 26 918-926 (2012) [C1]

Co-authors: Lisa Lincz

2012Mhaidat NM, Abdul-Razzak KK, Alkofahi AS, Alsarhan AM, Aldaher AN, Thorne RF, 'Altholactone induces apoptotic cell death in human colorectal cancer cells', Phytotherapy Research, 26 926-931 (2012) [C1]
2011Jiang CC, Lai F, Thorne RF, Yang F, Liu H, Hersey P, Zhang XD, 'MEK-independent survival of B-RAFV600E melanoma cells selected for resistance to apoptosis induced by the RAF inhibitor PLX4720', Clinical Cancer Research, 17 721-730 (2011) [C1]

Co-authors: Xu Zhang

2011Alkhatatbeh MJ, Mhaidat NM, Enjeti AK, Lincz L, Thorne RF, 'The putative diabetic plasma marker, soluble CD36, is non-cleaved, non-soluble and entirely associated with microparticles', Journal of Thrombosis and Haemostasis, 9 844-851 (2011) [C1]
2011Sadeqzadeh E, De Bock CE, Zhang XD, Shipman KL, Scott NM, Song C, et al., 'Dual processing of FAT1 cadherin protein by human melanoma cells generates distinct protein products', Journal of Biological Chemistry, 286 28181-28191 (2011) [C1]
2011Jin L, Hu WL, Jiang CC, Wang JX, Han CC, Chu P, et al., 'MicroRNA-149*, a p53-responsive microRNA, functions as an oncogenic regulator in human melanoma', Proceedings of the National Academy of Sciences, 108 15840-15845 (2011) [C1]

Co-authors: Xu Zhang

2011Dong L, Jiang CC, Thorne RF, Croft A, Yang F, Liu H, et al., 'Ets-1 mediates upregulation of Mcl-1 downstream of XBP-1 in human melanoma cells upon ER stress', Oncogene, 30 3716-3726 (2011) [C1]
2010Thorne RF, Ralston KJ, De Bock CE, Mhaidat NM, Zhang XD, Boyd AW, Burns GF, 'Palmitoylation of CD36/FAT regulates the rate of its post-transcriptional processing in the endoplasmic reticulum', Biochimica et Biophysica Acta - Molecular Cell Research, 1803 1298-1307 (2010) [C1]
2010Tseng H-Y, Jiang CC, Croft A, Croft A, Thorne RF, Yang F, et al., 'Contrasting effects of Nutlin-3 on TRAIL - and Docetaxel-induced Apoptosis due to upregulation of TRAIL-R2 and Mcl-1 in human melanoma cells', Molecular Cancer Therapeutics, 9 3363-3374 (2010) [C1]
2010Mao ZG, Jiang CC, Thorne RF, Hersey P, Zhang XD, 'TRAIL-induced apoptosis of human melanoma cells involves activation of caspase-4', Apoptosis, 15 1211-1222 (2010) [C1]
2010Jiang CC, Lai F, Tay KH, Croft A, Rizos H, Becker TM, et al., 'Apoptosis of human melanoma cells induced by inhibition of B-RAF(V600E) involves preferential splicing of bim(S)', Cell Death & Disease, 1 e69 (2010) [C1]
2010Yang F, Tay KH, Dong L, Thorne RF, Jiang CC, Yang E, et al., 'Cystatin B inhibition of TRAIL-induced apoptosis is associated with the protection of FLIPL from degradation by the E3 ligase itch in human melanoma cells', Cell Death and Differentiation, 17 1354-1367 (2010) [C1]
2010Zhang X, Thorne RF, Wagner TE, Wei Y, 'Regulatory T cells and cancer therapy: An old story with a new hope', Current Cancer Therapy Reviews, 6 34-40 (2010) [C1]
2009Jiang CC, Yang F, Thorne RF, Zhu BK, Hersey P, Zhang XD, 'Human melanoma cells under endoplasmic reticulum stress acquire resistance to microtubule-targeting drugs through XBP-1-mediated activation of Akt', Neoplasia, 11 436-447 (2009) [C1]

DOI: 10.1593/neo.09208

Co-authors: Xu Zhang

2009Zhang LJ, Chen S, Wu P, Hu CS, Thorne RF, Luo CM, et al., 'Inhibition of MEK blocks GRP78 up-regulation and enhances apoptosis induced by ER stress in gastric cancer cells', Cancer Letters, 274 40-46 (2009) [C1]
2009Mhaidat NM, Alali FQ, Matalqah SM, Matalka II, Jaradat SA, Al-Sawalha NA, Thorne RF, 'Inhibition of MEK sensitizes paclitaxel-induced apoptosis of human colorectal cancer cells by downregulation of GRP78', Anti-Cancer Drugs, 20 601-606 (2009) [C1]
2008Mhaidat NM, Thorne RF, Zhang XD, Hersey P, 'Involvement of endoplasmic reticulum stress in Docetaxel-induced JNK-dependent apoptosis of human melanoma', Apoptosis, 13 1505-1512 (2008) [C1]
2008Zhang LJ, Hao YZ, Hu CS, Ye Y, Xie QP, Thorne RF, et al., 'Inhibition of apoptosis facilitates necrosis induced by cisplatin in gastric cancer cells', Anti-Cancer Drugs, 19 159-166 (2008) [C1]
2008Jiang CC, Lucas K, Kiejda KA, Wade M, Debock CE, Thorne RF, et al., 'Up-regulation of Mcl-1 is critical for survival of human melanoma cells upon endoplasmic reticulum stress', Cancer Research, 68 6708-6717 (2008) [C1]
2008Mhaidat NM, Thorne RF, De Bock CE, Zhang XD, Hersey P, 'Melanoma cell sensitivity to docetaxal-induced apoptosis is determined by class III beta-tubulin levels', FEBS Letters, 582 267-272 (2008) [C1]
2008Chen LH, Jiang CC, Watts R, Thorne RF, Kiejda KA, Zhang XD, Hersey P, 'Inhibition of endoplasmic reticulum stress-induced apoptosis of melanoma cells by the ARC protein', Cancer Research, 68 834-842 (2008) [C1]
2008Mhaidat NM, Thorne RF, De Bock CE, Zhang XD, Hersey P, 'Melanoma cell sensitivity to Docetaxel-induced apoptosis is determined by class III ß-tubulin levels', FEBS Letters, 582 267-272 (2008) [C1]
2007Thorne RF, Mhaidat N, Ralston KJ, Burns GF, 'CD36 is a receptor for oxidized high density lipoprotein: Implications for the development of atherosclerosis', FEBS Letters, 581 1227-1232 (2007) [C1]
2007Mhaidat NM, Thorne RF, Zhang XD, Hersey P, 'Regulation of docetaxel-induced apoptosis of human melanoma cells by different isoforms of protein kinase C', Molecular Cancer Research, 5 1073-1081 (2007) [C1]
2007Chen LH, Jiang CC, Kiejda KA, Wang YF, Thorne RF, Zhang XD, Hersey P, 'Thapsigargin sensitizes human melanoma cells to TRAIL-induced apoptosis by up-regulation of TRAIL-R2 through the unfolded protein response', Carcinogenesis, 28 2328-2336 (2007) [C1]
2007Thorne RF, Mhaidat N, Ralston KJ, Burns GF, 'Shed gangliosides provide detergent-independent evidence for type-3 glycosynapses', Biochemical and Biophysical Research Communications, 356 306-311 (2007) [C1]
2007Gillespie S, Kiejda KA, Mhaidat N, Yu FW, Thorne RF, Zhang XD, et al., 'Tunicamycin sensitizes human melanoma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by up-regulation of TRAIL-R2 via the unfolded protein response', Cancer Research, 67 5880-5888 (2007) [C1]
2006Thorne RF, Law E, Elith CA, Ralston KJ, Bates RC, Burns GF, 'The association between CD36 and Lyn protein tyrosine kinase is mediated by lipid', Biochemical and Biophysical Research Communications, 351 51-56 (2006) [C1]
2006Thorne RF, Zhang XH, Song CJ, Jin BQ, Burns GF, 'Novel immunoblotting monoclonal antibodies against human and rat CD36/fat used to identify an isoform of CD36 in rat muscle', DNA and Cell Biology, 25 302-311 (2006) [C1]
2006Tzircotis G, Thorne RF, Isacke CM, 'Directional sensing of a phorbol ester gradient requires CD44 and is regulated by CD44 phosphorylation', Oncogene, 25 7401-7410 (2006) [C1]
2005Tzircotis G, Thorne RF, Isacke CM, 'Chemotaxis towards hyaluronan is dependent on CD44 expression and modulated by cell type variation in CD44-hyaluronan binding', Journal of Cell Science, 118 5119-5128 (2005) [C1]
2004Thorne RF, Legg JW, Isacke CM, 'The role of the CD44 transmembrane and cytoplasmic domains in co-ordinating adhesive and signalling events', JOURNAL OF CELL SCIENCE, 117 373-380 (2004) [C1]
2004Ralston KJ, Hird S, Zhang X, Scott JL, Jin B, Thorne RF, et al., 'The LFA-1-associated molecule PTA-1 (CD226) on T cells forms a dynamic molecular complex with protein 4.1G and human discs large', Journal of Biological Chemistry, 279 33816-33828 (2004) [C1]
2003Sullivan A, Uff CR, Isacke CM, Thorne RF, 'PACE-1, a novel protein that interacts with the C-terminal domain of ezrin', EXPERIMENTAL CELL RESEARCH, 284 224-238 (2003) [C1]
2000Gruarin P, Thorne R, Dorahy DJ, Burns G, Sitia R, Alessio M, 'CD36 is a Ditopic Glycoprotein with the N-Terminal Domain Implicated in Intracellular Transport', Biochemical and Biophysical Research Communications, 275 446-454 (2000) [C1]
2000Shafren D, Dorahy DJ, Thorne R, Barry R, 'Cytoplasmic interactions between decay-accelerating factor and intercellular adhesion molecule-1 are not required for coxsackievirus A21 cell infection', Journal of General Virology, 81 889-894 (2000) [C1]

Co-authors: Darren Shafren

2000Gruarin P, Ulliers D, Thorne RF, Alessio M, 'Methionine 156 in the immunodominant domain on CD36 contributes to define the epitope recognized by the NL07 MoAb', Molecular and Cellular Biochemistry, 214 89-95 (2000) [C1]
2000Thorne RF, Marshall J, Shafren D, Gibson P, Hart I, Burns GF, 'The Integrins (alpha)3(beta)1 Physically and functionally Associate with CD36 in Human Melanoma Cells', The Journal of Biological Chemistry, 275 No. 45 35264-35275 (2000) [C1]
2000Thorne R, Marshall J, Shafren D, Gibson PG, Hart I, Burns G, 'The Integrins a3B1 and a6B1 Physically and Functionally Associate with CD36 in Human Melanoma Cells', Journal of Biological Chemistry, 275 35264-35275 (2000) [C1]

Co-authors: Peter Gibson

1998Shafren DR, Dorahy DJ, Thorne RF, Kinoshita T, Barry RD, Burns GF, 'Antibody binding to individual short consensus repeats of decay-accelerating factor enhances enterovirus cell attachment and infectivity', The Journal of Immunology, 160 2318-2323 (1998) [C1]

Co-authors: Darren Shafren

1998Bates RC, Elith CA, Thorne RF, Burns GF, 'Engagement of Variant CD44 confers resistance to anti-integrin antibody-mediated apoptosis in a colon carcinoma cell line', Cell Adhesion and Communication, 6 (1) 21-38 (1998) [C1]
1998Gruarin P, Sitia R, Thorne RF, Burns GF, Alessio M, 'CD36 is a ditopic glycoprotein with both transmembrane domains implicated in intracellular transport.', MOLECULAR BIOLOGY OF THE CELL, 9 456A-456A (1998)
1997Radford KJ, Thorne RF, Hersey P, 'Regulation of tumor cell motility and migration by CD63 in a human melanoma cell line', JOURNAL OF IMMUNOLOGY, 158 3353-3358 (1997)
1997Thorne RF, Meldrum CJ, Harris SJ, Dorahy DJ, Shafren DR, Berndt MC, et al., 'CD36 forms covalently associated dimers and multimers in platelets and transfected COS-7 cells', BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 240 812-818 (1997)
1997Dorahy DJ, Thorne RF, Fecondo JV, Burns GF, 'Stimulation of platelet activation and aggregation by a carboxyl-terminal peptide from thrombospondin binding to the integrin-associated protein receptor', JOURNAL OF BIOLOGICAL CHEMISTRY, 272 1323-1330 (1997)
1996Radford KJ, Thorne RF, Hersey P, 'CD63 associates with transmembrane 4 superfamily members, CD9 and CD81, and with beta 1 integrins in human melanoma', BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 222 13-18 (1996)
1989SMART YC, STEVENSON KL, THORNE RF, THOMAS WD, HSU LH, BURTON RC, 'EXPRESSION OF NATURAL-KILLER (NK) CELL-SPECIFIC ALLOANTIGENS ON A MOUSE NK-LIKE CELL-LINE', IMMUNOLOGY AND CELL BIOLOGY, 67 239-242 (1989)
Show 59 more

Conference (15 outputs)

YearCitationAltmetricsLink
2013Ahmed AF, De Bock CE, Sontag E, Hondermarck H, Thorne RF, 'The functional role of Fat1 cadherin in the differentiation and proliferation of SH-SY5Y neuroblastoma cells', -, Pokolbin, NSW, Australia (2013) [E3]
2012Li J, Imtiaz MS, Beard NA, Dulhunty AF, Thorne RF, Van Helden DF, Laver DR, 'Adrenergic stimulation alters RyR2 regulation by Ca2+ and Mg2+', Heart, Lung and Circulation: Abstracts of ISHR Auckland Workshop, Auckland, NZ (2012) [E3]
2012Li J, Imtiaz MS, Beard NA, Dulhunty AF, Thorne RF, Van Helden DF, Laver DR, 'Adrenergic stimulation increases RYR2 activity via intracellular Ca2+ and Mg2+ regulation', Sydney 2012 Joint AuPS/PSNZ/ASB Meeting. Programme, Sydney, NSW (2012) [E3]
2011Ardjmand Ghahestani A, De Bock CE, Molloy TJ, Bone SM, Johnstone DM, Campbell DM, et al., 'Altered expression of Fat1 cadherin, a novel tumor marker for acute lymphoblastic leukemia', Clinical Biochemistry, Mashhad, Iran (2011) [E3]

Co-authors: Lisa Lincz

2011Ye Y, Jin L, Wilmott J, Hu WL, Thorne RF, Dong L, et al., 'Phosphatidylinositol 4,5-Bisphosphate 5-Phosphatase A regulates PI3K/Akt signaling in human melanoma cells', Pigment Cell & Melanoma Research, Tampa, FL (2011) [E3]

Co-authors: Xu Zhang

2011Sadeqzadeh E, Hersey P, Zhang XD, Debock C, Boyd A, Burns GF, Thorne RF, 'Aberrant processing of Fat1 Cadherin in human cancer', Clinical Biochemistry, Mashhad, Iran (2011) [E3]

Co-authors: Xu Zhang

2011Alkhatatbeh MJ, Mhaidat NM, Enjeti AK, Lincz LF, Thorne RF, 'Circulating plasma CD36+microparticles as a marker of type 2 diabetes and its complications', Clinical Biochemistry, Mashhad, Iran (2011) [E3]

Co-authors: Lisa Lincz

2010Zhang XD, Jiang CC, Lai F, Croft A, Tay KH, Thorne RF, et al., 'Apoptotic response of mutant B-RAF human melanoma cells to a B-RAF inhibitor involves increased splicing production of BimS', AACR 101st Annual Meeting 2010. Abstracts, Washington, DC (2010) [E3]

Co-authors: Xu Zhang

2010Jiang CC, Zhuang LQ, Dong L, Thorne RF, Lavis CJ, Hersey P, Zhang XD, 'Adaptation to ER stress as a driver of increased expression of Mcl-1 with melanoma progression', AACR 101st Annual Meeting 2010. Abstracts, Washington, DC (2010) [E3]

Co-authors: Xu Zhang

2010Yang XM, Chen LH, Jiang CC, De Bock CE, Thorne RF, Hersey P, Zhang XD, '40p53 is up-regulated and plays a role in antagonizing p53-mediated apoptosis in human melanoma', Pigment Cell & Melanoma Research, Sydney, Australia (2010) [E3]

Co-authors: Xu Zhang

2010Dong L, Jiang CC, Thorne RF, Yang F, Liu H, De Bock CE, et al., 'Transcriptional up-regulation of Mcl-1 by ETS1 down-stream of XBP-1 in melanoma cells upon ER stress', Pigment Cell & Melanoma Research, Sydney, Australia (2010) [E3]

Co-authors: Xu Zhang

2010Salum De Oliveira C, Yan XG, Hersey P, Zhang XD, Thorne RF, 'The role of MIF signaling in melanoma progression', AACR 101st Annual Meeting 2010. Abstracts, Washington, DC (2010) [E3]

Co-authors: Xu Zhang

2010Chen LH, Yang F, Tay KH, Dong L, Thorne RF, Jiang CC, et al., 'Cystatin B inhibition of TRAIL-induced apoptosis is associated with protection of FLIPLfrom degradation by the E3 ligase itch human melanoma cells', Pigment Cell & Melanoma Research, Sydney, Australia (2010) [E3]
2010Tseng HY, Jiang CC, Croft A, Tay KH, Yang F, Liu H, et al., 'Contrasting effects of nutlin-3 on TRAIL- and docetaxel-induced apoptosis in human melanoma cells', Melanoma 2010 Congress. Oral and Poster Abstracts, Sydney, NSW (2010) [E3]
2001Law E, Thorne RF, Zhang XY, Burns GF, Boyd A, 'Fat Protocadherin as a Mechanical Regulator of Melanoma Cell Migration', Melanoma Research, Venice - 28 February to 3 March 2001 (2001) [E3]
Show 12 more
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Grants and Funding

Summary

Number of grants39
Total funding$5,855,482

- Indicates that the researcher may be seeking students for this project.

Click on a grant title below to expand the full details for that specific grant.

2014 (2 grants)

High Throughput Image Capture Platform for Translational Cancer Research$282,614
Funding Body: Cancer Institute NSW

Project Team
Conjoint Professor Stephen Ackland, Professor Rodney Scott, Professor John Forbes, Professor Xu Dong Zhang, Professor Marjorie Walker, Professor Hubert Hondermarck, Doctor Craig Gedye, Doctor Rick Thorne, Mr Loui Rassam, Doctor Stephen Braye
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$282,61420142014
GNo:G1400626

What is different about red blood cells in people with type 2 diabetes?$50,000
Funding Body: Hunter Medical Research Institute

Project Team
Doctor Lisa Lincz, Doctor Rick Thorne
SchemeRole
Project GrantInvestigator
Total AmountFunding StartFunding Finish
$50,00020142014
GNo:G1401416

2013 (3 grants)

Functional consequences of epigenetic repression of PIB5PA in melanoma$359,250
Funding Body: Cancer Council NSW

Project Team
Professor Xu Dong Zhang, Dr Helen Rizos, Doctor Rick Thorne, Doctor Chen Chen Jiang
SchemeRole
Research GrantInvestigator
Total AmountFunding StartFunding Finish
$359,25020132015
GNo:G1200386

Ultra-Low Temperature Cryogenic Freezer$24,596
Funding Body: NHMRC (National Health & Medical Research Council)

Keystone Meeting: The Hippo Tumor Suppressor Network, Monterey USA, 19-23 May 2013$2,000
Funding Body: University of Newcastle - Faculty of Health and Medicine

Project Team
Doctor Rick Thorne
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$2,00020132013
GNo:G1300652

2012 (5 grants)

Targeting Histone Deacetylases to Overcome Resistance of BRAFV600E Melanoma Cells to Apoptosis$346,974
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Xu Dong Zhang, Conjoint Professor Peter Hersey, Dr Tao Liu, Doctor Chen Chen Jiang, Doctor Rick Thorne
SchemeRole
Project GrantInvestigator
Total AmountFunding StartFunding Finish
$346,97420122014
GNo:G1100133

High-Resolution Isoelectric Phosphoprotein Signalling System for Signalling Research, Biomarker Validation and Drug Development – Equipment Grant$143,394
Funding Body: Hunter Medical Research Institute

Project Team
Doctor Rick Thorne, Professor Xu Dong Zhang, Professor Hubert Hondermarck, Conjoint Professor Stephen Ackland, Doctor Lisa Lincz, Doctor Jennette Sakoff, Emeritus Professor Leonie Ashman
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$143,39420122012
GNo:G1200555

Microscopic illumination system for advanced fluorescent protein technology$34,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Doctor Rick Thorne, Professor Xu Dong Zhang, Conjoint Associate Professor Murray Cairns, Doctor Nikki Verrills, Doctor Charles De Bock, Doctor Jude Weidenhofer, Doctor Severine Roselli, Doctor Kathryn Skelding, Emeritus Professor Leonie Ashman, Professor Hubert Hondermarck
SchemeRole
Equipment GrantChief Investigator
Total AmountFunding StartFunding Finish
$34,00020122012
GNo:G1100983

A p53-Mediated Pro-Survival Signaling Pathway in Human Melanoma Progression and Resistance to Treatment$20,000
Funding Body: University of Newcastle

Project Team
Professor Xu Dong Zhang, Doctor Rick Thorne, Doctor Chen Chen Jiang
SchemeRole
Near Miss GrantInvestigator
Total AmountFunding StartFunding Finish
$20,00020122012
GNo:G1200672

Establishment of Fat1 cadherin as biomarker and unique target for anti-cancer therapy in paediatric acute lymphoblastic leukaemia$20,000
Funding Body: Hunter Medical Research Institute

Project Team
Doctor Rick Thorne, Doctor Charles De Bock, Doctor Lisa Lincz
SchemeRole
Research GrantChief Investigator
Total AmountFunding StartFunding Finish
$20,00020122012
GNo:G1200222

2011 (1 grants)

IMPLEN NanoPhotometer pearl$10,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Conjoint Associate Professor Murray Cairns, Associate Professor Paul Tooney, Associate Professor Alan Brichta, Emeritus Professor John Rostas, Emeritus Professor Patricia Michie, Conjoint Professor Keith Jones, Professor Ulli Schall, Associate Professor Phillip Dickson, Doctor Frederick Walker, Doctor Rick Thorne, Doctor Chris Dayas, Doctor Nikki Verrills, Doctor Janet Holt, Doctor Severine Roselli, Doctor Kathryn Skelding, Doctor Jude Weidenhofer, Associate Professor Liz Milward, Doctor Charles De Bock, Doctor Julie Merriman-Jones, Doctor Jing Qin Wu, Doctor Bing Liu, Mr Dan Johnstone, Ms Belinda Goldie, Ms Natalie Beveridge
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$10,00020112011
GNo:G1100030

2010 (6 grants)

Laser microdissection microscopy system for cell and development biology$350,000
Funding Body: ARC (Australian Research Council)

Laser microdissection microscopy system for cell and development biology$215,000
Funding Body: University of Newcastle

Pathogenic Function of Plasma CD36 Mircroparticles in Mediating Complications of Type 2 Diabetes$98,000
Funding Body: Hunter Medical Research Institute

Project Team
Doctor Rick Thorne, Doctor Lisa Lincz
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$98,00020102011
GNo:G0900121

ABI 7500 Real Time PCR System $34,000
Funding Body: NHMRC (National Health & Medical Research Council)

Electron Multiplier Charge-Coupled Device Camera. Hamamatsu EM-CCD Camera C9100-13$29,079
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Conjoint Professor Keith Jones, Professor Eileen McLaughlin, Professor Dirk Van Helden, Doctor Rick Thorne
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$29,07920102010
GNo:G1000052

AACR 101st Annual Meeting, Washington DC, 17 - 21st April 2010$2,000
Funding Body: University of Newcastle - Faculty of Health and Medicine

Project Team
Doctor Rick Thorne
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$2,00020102010
GNo:G1000133

2009 (7 grants)

An Advanced Mass Spectrometry Facility for Applications in Proteomics and Organic Chemistry$495,000
Funding Body: ARC (Australian Research Council)

Targeting adaptive mechanisms to endoplasmic reticulum stress in melanoma$491,250
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Xu Dong Zhang, Conjoint Professor Peter Hersey, Doctor Rick Thorne
SchemeRole
Project GrantInvestigator
Total AmountFunding StartFunding Finish
$491,25020092011
GNo:G0188902

Confocal Laser Scanning Microscopy for Live Cell Imaging$275,000
Funding Body: ARC (Australian Research Council)

An Advanced Mass Spectrometry Facility for Applications in Proteomics and Organic Chemistry$50,000
Funding Body: ARC (Australian Research Council)

FACSAria$30,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Doctor Rick Thorne, Doctor Severine Roselli, Professor Xu Dong Zhang, Dr Charles De Bock, Conjoint Professor Peter Hersey, Professor Gordon Burns
SchemeRole
Equipment GrantChief Investigator
Total AmountFunding StartFunding Finish
$30,00020092009
GNo:G0189846

Identification of leukaemic stem cells based upon their expression of a novel surface marker, Fat1$25,000
Funding Body: Hunter Medical Research Institute

Project Team
Doctor Rick Thorne, Doctor Lisa Lincz
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$25,00020092009
GNo:G0189791

Hunter Cell Biology Meeting, Pokolbin, 24-27 March 2009$600
Funding Body: University of Newcastle - Faculty of Health and Medicine

Project Team
Doctor Rick Thorne
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$60020092009
GNo:G0190131

2008 (4 grants)

Involvement of the MIF-CD74-CD44 signalling complex in melanoma progression$600,000
Funding Body: Cancer Institute NSW

Project Team
Doctor Rick Thorne
SchemeRole
Career Development FellowshipChief Investigator
Total AmountFunding StartFunding Finish
$600,00020082010
GNo:G0188173

Colibri high-performance LED illumination system for fluorescence live cell microscopy$23,225
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Doctor Rick Thorne, Dr Charles De Bock, Professor Xu Dong Zhang, Doctor Lisa Lincz, Professor Gordon Burns, Conjoint Professor Peter Hersey, Professor Dirk Van Helden, Conjoint Professor Keith Jones, Professor Roger Smith
SchemeRole
Equipment GrantChief Investigator
Total AmountFunding StartFunding Finish
$23,22520082008
GNo:G0188545

Biogenesis of circulating plasma microparticles in the metabolic syndrome$8,450
Funding Body: University of Newcastle

Project Team
Doctor Rick Thorne, Doctor Lisa Lincz
SchemeRole
Pilot GrantChief Investigator
Total AmountFunding StartFunding Finish
$8,45020082008
GNo:G0189072

Biogenesis of circulating plasma microparticles in the metabolic syndrome$8,450
Funding Body: University of Newcastle - Faculty of Health and Medicine

Project Team
Doctor Rick Thorne, Doctor Lisa Lincz
SchemeRole
Pilot GrantChief Investigator
Total AmountFunding StartFunding Finish
$8,45020082008
GNo:G0189385

2007 (5 grants)

Characterisation and antibody - mediated targeting of a novel specific marker for T cell all/lymphoblastic lymphoma$564,500
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Gordon Burns, Professor Andrew Boyd, Doctor Rick Thorne, Assoc. Prof Alpha Yap
SchemeRole
Project GrantInvestigator
Total AmountFunding StartFunding Finish
$564,50020072009
GNo:G0186374

FACSAria - Fluorescence activated cell sorter$300,000
Funding Body: Cancer Institute NSW

Project Team
Doctor Nikki Verrills, Emeritus Professor Leonie Ashman, Laureate Professor John Aitken, Professor Eileen McLaughlin, Professor Alistair Sim, Doctor Rick Thorne, Doctor Jennette Sakoff
SchemeRole
Infrastructure GrantsInvestigator
Total AmountFunding StartFunding Finish
$300,00020072007
GNo:G0187666

HMRI Contribution toward FACSAria - Fluorescence activated cell sorter$52,000
Funding Body: Hunter Medical Research Institute

Project Team
Doctor Nikki Verrills, Emeritus Professor Leonie Ashman, Laureate Professor John Aitken, Professor Eileen McLaughlin, Professor Alistair Sim, Doctor Rick Thorne, Doctor Jennette Sakoff
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$52,00020072007
GNo:G0188207

High speed/sensitivity CCD camera$30,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Dirk Van Helden, Professor Eileen McLaughlin, Professor Gordon Burns, Doctor Rick Thorne, Dr Marcus Howlett, Doctor Mohammad Imtiaz, Associate Professor Alan Brichta, Professor Robert Callister, Doctor Brett Graham, Associate Professor Derek Laver, Associate Professor Liz Milward, Doctor John Holdsworth
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$30,00020072007
GNo:G0188196

A novel adhesive target involved in the survival of leukaemia cells$20,000
Funding Body: Hunter Medical Research Institute

Project Team
Doctor Rick Thorne, Doctor Lisa Lincz
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$20,00020072007
GNo:G0187243

2006 (2 grants)

Live cell imaging facility$149,100
Funding Body: Cancer Institute NSW

Project Team
Doctor Rick Thorne, Doctor Nikki Verrills, Professor Alistair Sim, Professor Gordon Burns
SchemeRole
Infrastructure GrantsChief Investigator
Total AmountFunding StartFunding Finish
$149,10020062006
GNo:G0186146

High speed computer for a live cell imaging system$3,000
Funding Body: Hunter Medical Research Institute

Project Team
Doctor Rick Thorne, Professor Gordon Burns, Doctor Nikki Verrills, Professor Alistair Sim
SchemeRole
Equipment GrantChief Investigator
Total AmountFunding StartFunding Finish
$3,00020062006
GNo:G0187279

2005 (2 grants)

2005 RIBG allocation$32,000
Funding Body: University of Newcastle

Project Team
Doctor Rick Thorne
SchemeRole
Research Infrastructure Block Grant (RIBG)Chief Investigator
Total AmountFunding StartFunding Finish
$32,00020052005
GNo:G0185802

Understanding how some cancer cells survive low oxygen tension$8,000
Funding Body: University of Newcastle

Project Team
Doctor Rick Thorne
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$8,00020052005
GNo:G0184753

2004 (1 grants)

Investigation of a phagocytic-synapse in the uptake of apoptotic cells$660,000
Funding Body: ARC (Australian Research Council)

Project Team
Professor Gordon Burns, Professor M Berndt, Professor Andrew Boyd, Professor P Hogg, Doctor Rick Thorne
SchemeRole
Discovery ProjectsInvestigator
Total AmountFunding StartFunding Finish
$660,00020042006
GNo:G0182803

2001 (1 grants)

Analysis of a Novel Membrane Insertion Motif in the CD36 Glycoprotein$9,000
Funding Body: University of Newcastle

Project Team
Doctor Rick Thorne
SchemeRole
New Staff GrantChief Investigator
Total AmountFunding StartFunding Finish
$9,00020012001
GNo:G0180732
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Research Supervision

Number of current supervisions3
Total current UoN PhD EFTSL0.4

For supervisions undertaken at an institution other that the University of Newcastle, the institution name is listed below the program name.

Current Supervision

CommencedProposed
Completion
ProgramSupervisor TypeResearch Title
20112015PhD (Medical Biochemistry)Principal SupervisorRole of FAT1 Cadherin in Neuronal differentiation
20072007Honours Biochemistry & Cell Biology
University of Newcastle
Principal SupervisorRole of Fat1 cadherin in melanoma progression
20072007Honours Biochemistry & Cell Biology
University of Newcastle
Co-SupervisorA novel adhesive target involved in acute lympohoblastic leukemia

Past Supervision

YearProgramSupervisor TypeResearch Title
2014PhD (Medical Biochemistry)Principal SupervisorAnalysis of Fat1 Cadherin and Identification of Novel Biomarkers for Acute Leukemia
2014PhD (Medical Biochemistry)Principal SupervisorAnalysis of Post-Translational Modifications of Fat1 Cadherin
2013PhD(Experimental Pharmacology)Principal SupervisorBiogenesis of Plasma CD36+Microparticles in Human Diabetes and the Metabolic Syndrome
2013PhD (Medical Biochemistry)Principal SupervisorThe Role of MIF in Melanoma Progression
2008PhD (Medicine)Co-SupervisorCharacterisation of the Multifunctional Protein, CREAP
2005Honours Biochemistry & Cell Biology
University of Newcastle
Principal SupervisorRole of Fat1 cadherin in breast cancer metastasis
2005PHD Medical Science
Institute of Cancer Research, UK (Affilitated to Univeristy of London)
Co-SupervisorTBA
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Dr Rick Thorne

Work Phone(02) 4921 7860
Fax(02) 4921 7867
Email
PositionsHMRI Research Fellow
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine
The University of Newcastle, Australia
Conjoint Senior Lecturer
School of Environmental and Life Sciences
Faculty of Science and Information Technology
The University of Newcastle, Australia
Focus AreaMedical Biochemistry
Office
LS3-33,
Life Sciences,
Callaghan
University Drive
Callaghan NSW 2308
Australia
URL:www.newcastle.edu.au/profile/rick-thorne