Dr Rachel Wong
School of Biomedical Sciences and Pharmacy
- Phone:(02) 4921 6408
Rachel recently obtained her doctorate degree at the University of South Australia. She is currently a postdoctoral research fellow at the Clinical Nutrition Research Centre, The University of Newcastle. She is a member of International Society of Hypertension, High Blood Pressure Research Council of Australia and the Nutrition Society of Australia. Her research focuses on the effects of bioactive nutrients in human circulatory function and cognitive performance. She was among the first to investigate the acute effects of trans-resveratrol supplementation in human vascular function. Since then Rachel has evaluated effects of chronic consumption of an oat extract on vasodilator function in systemic and cerebral arteries of older adults and its relationship with cognition. Her most recent work follows on from the acute resveratrol study to look at chronic resveratrol supplementation on vasodilator function and its impact on cognitive performance in obese adults. Rachel is currently investigating the relationships between ceberal blood flow haemodynamics and cognitive performance in adults with type 2 diabetes.Research Expertise
Dr Rachel Wong was already recognised as a high performing student during her undergraduate and subsequent Honours research on the clinical evaluation of cardiovascular benefits of a nutrient intervention and subsequently extending into clinical assessment of cognitive functions during her PhD training. Nutrients evaluated were trans-resveratrol and wild green oat extract. Rachel has expertise in vascular imaging of the systemic and cerebral arteries using ultrasound techniques (flow-mediated dilatation of the brachial artery and transCranial Doppler ultrasound) that enable quantification of the responsiveness of blood vessels to meet specific demands of the body. She also has extensive experience in clinical trials management including knowledge on subject recruitment and retention, ability to conduct clinical trials in accordance with principles of Good Clinical Practice and maintaining rigour in all aspects of research performance and analysis. She has recently completed a clinical evaluation of the olive leaf extract combination on 24-hr ambulatory blood pressure in hypertensive adults.
Undergraduate teaching: (1) Appointed as a tutor and practical demonstrator for Human Physiology and Human Nutrition courses offered to undergraduate students in the Division of Health Sciences. (2) Examined an honours thesis: ‘Effects of exercise on systemic and cerebral vascular function’. Training of research students in: (1) ultrasound imaging and analysis of flow-mediated dilatation in the brachial artery and cerebrovascular responsiveness to hypercapnic and cognitive stimuli using transCranial Doppler ultrasound. (2) administration of dementia status test and cognitive tests. (3) clinical trial management in accordance with the ICH-GCP Standard. Co-Supervision at University of Newcastle: (1) Neuropsychology Research Masters graduate (thesis: 'Cerebral blood flow and cognition in diabetes’). (2) PhD candidate in ‘Cerebral hemodynamics following visuo-vestibular-invoked nausea’. (3) Overseas exchange undergraduate students
Clinical Research Coordinator (CCRC, Association of Clinical Research Professionals) - conduct clinical trials under ICH-GCP guidelines.
- PhD (Health Sciences), University of South Australia
- Bachelor of Applied Science (Human Movement), University of South Australia
- Bachelor of Health Sciences (Honours), University of South Australia
- Cardiovascular health
- Human Nutrition
- Human Physiology
- Transcranial Doppler ultrasound
- Mandarin (Fluent)
Fields of Research
|110201||Cardiology (incl. Cardiovascular Diseases)||30|
|170299||Cognitive Sciences not elsewhere classified||30|
|Dates||Title||Organisation / Department|
|1/07/2015 - 31/12/2015||Research Associate||University of Newcastle|
School of Biomedical Sciences and Pharmacy
|Dates||Title||Organisation / Department|
|1/01/2009 -||Membership - Nutritional Society of Australia||Nutritional Society of Australia|
For publications that are currently unpublished or in-press, details are shown in italics.
Journal article (7 outputs)
|2014||Wong R, Garg M, Wood L, Howe P, 'Antihypertensive Potential of Combined Extracts of Olive Leaf, Green Coffee Bean and Beetroot: A Randomized, Double-Blind, Placebo-Controlled Crossover Trial', Nutrients, 6 4881-4894 (2014) [C1]|
|2014||Wong RHX, Scholey A, Howe PRC, 'Assessing Premorbid Cognitive Ability in Adults With Type 2 Diabetes Mellitus-a Review With Implications for Future Intervention Studies', CURRENT DIABETES REPORTS, 14 (2014) [C1]|
|2013||Wong RHX, Coates AM, Buckley JD, Howe PR, 'Evidence for circulatory benefits of resveratrol in humans', Annals of the New York Academy of Sciences, 1290 52-58 (2013) [C1]|
|2013||Wong RHX, Berry NM, Coates AM, Buckley JD, Bryan J, Kunz I, Howe PRC, 'Chronic resveratrol consumption improves brachial flow-mediated dilatation in healthy obese adults', Journal of Hypertension, 31 1819-1827 (2013) [C1]|
Background: We have previously demonstrated acute dose-dependent increases of flow-mediated dilatation (FMD) in the brachial artery after resveratrol consumption in mildly hyperte... [more]
Background: We have previously demonstrated acute dose-dependent increases of flow-mediated dilatation (FMD) in the brachial artery after resveratrol consumption in mildly hypertensive, overweight/obese adults. Resveratrol supplementation has also been shown to increase cerebral blood flow acutely, without affecting cognition. Objectives: To evaluate the effects of chronic resveratrol supplementation on both FMD and cognitive performance. Method: Twenty-eight obese but otherwise healthy adults (BMI: 33.3Â±0.6kg/m 2) were randomized to take a single 75 mg capsule of trans-resveratrol (Resvida) or placebo daily for 6 weeks each in a double-blind crossover supplementation trial. Blood pressure, arterial compliance, FMD, and performance on the Stroop Color-Word Test were assessed at the end of each 6-week intervention period while fasted and at least 18 h after taking the last daily capsule. An additional capsule of the same supplement was then taken. FMD assessment was repeated 1 h later. Results: Chronic resveratrol supplementation for 6 weeks was well tolerated and resulted in a 23% increase in FMD compared with placebo (P = 0.021, paired t-test). The extent of increase correlated negatively with baseline FMD (r= -0.47, P=0.01). A single dose of resveratrol (75 mg) following chronic resveratrol supplementation resulted in a 35% greater acute FMD response than the equivalent placebo supplementation. These FMD improvements remained significant after adjusting for baseline FMD. Blood pressure, arterial compliance, and all components of the Stroop Color-Word Test were unaffected by chronic resveratrol supplementation. Conclusion: Daily resveratrol consumption was well tolerated and has the potential to maintain healthy circulatory function in obese adults. Â© 2013 Wolters Kluwer Health Lippincott Williams & Wilkins.
|Show 4 more journal articles|
Grants and Funding
|Number of grants||6|
Click on a grant title below to expand the full details for that specific grant.
20151 grants / $35,000
Effects of long-chain Omega-3 polyunsaturated fatty acid (LCn-3PUFA) supplementation on cerebral circulation and cognitive function$35,000
Funding body: Westfund Health
20144 grants / $143,860
Funding body: CRC for High Integrity Australian Pork
Dose response evaluation of resveratrol supplementation on cerebrovascular function, mood and cognitive performance in type 2 diabetes mellitus$45,000
Funding body: NHMRC (National Health & Medical Research Council)
|Funding body||NHMRC (National Health & Medical Research Council)|
|Project Team||Professor Peter Howe, Doctor Rachel Wong, Professor Andrew Scholey|
|Scheme||Dementia Collaborative Research Centres (DCRC)|
|Type Of Funding||Other Public Sector - Commonwealth|
Assisting post-menopausal women towards healthy ageing - can resveratrol enhance mood and counteract cognitive decline?$25,000
Funding body: Hunter Medical Research Institute
Dose response evaluation of resveratrol supplementation on cerebrovascular function, mood and cognitive performance in type 2 diabetes mellitus$23,560
Funding body: DSM Nutritional Products AG
20131 grants / $165,000
Funding body: Newcastle Innovation
|Commenced||Research Title / Program / Supervisor Type|
|2014||Lifestyle interventions to counteract cognitive decline in diabetes|
Human Biology, Faculty of Health and Medicine
April 27, 2015
Can the health supplement resveratrol curb the notorious hot flushes, insomnia, irritability and occasional mental lapses that often accompany menopause?
January 8, 2015
Researchers in the Clinical Nutrition Research Centre at the University of Newcastle are seeking people with type 2 diabetes to take a new nutritional supplement designed to stimulate blood flow in the brain and reduce the threat of mental impairment.
August 24, 2014
40-85 year old volunteers with slightly elevated blood pressure are needed.