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Dr Pradeep Tanwar

ARC Future Fellow

School of Biomedical Sciences and Pharmacy (Medical Biochemistry)

Career Summary

Biography

Dr Pradeep Tanwar is an ARC Future Fellow, a Cancer Institute NSW Career Development Fellow and an investigator of the Hunter Cancer Research Alliance.  Throughout his research career, Dr Tanwar’s research work has focussed on defining molecular footsteps involved in the pathogenesis of the reproductive tract cancers. In the last 5 years, Dr Tanwar’s work resulted in 15 research publications in high impact journals including PNAS x2, Cancer Research, Human Molecular Genetics, PLos Genetics, Nature Genetics and Carcinogenesis x3, and led to invitations to speak at various conferences/symposiums such as Gordon Conference on Reproductive Tract Biology and Reproductive and Endocrine-related Cancer Symposium jointly organised by the Society of Reproductive Biology and the Endocrine Society of Australia.  His group is using genetically modified mouse models, cancer patient-derived xenograft models and primary human tissue samples to define the molecular and cellular events involved in carcinogenesis and then using this knowledge to develop targeted therapies to improve clinical outcomes in human patients.

Research Expertise
1. Role of Microenvironment in Endometrial cancer 2. Wnt-PI3K-mTOR signaling axis, EMT (Epithelial Mesenchymal Transition), and ovarian cancer 3. Cancer stem cells in ovarian cancer 3. Pathogenesis of Genitourinary cancers

Teaching Expertise
Course coordinator for HUBS2107: Mammalian Growth and Development

Collaborations
Professor Patricia Donahoe, Harvard Medical School, USA Professor Jose Teixeira, Michigan State University, USA


Keywords

  • Cancer biology
  • Cancer stem cells
  • Endometrial cancer
  • Genetics
  • Genitourinary cancers
  • Gynecologic oncology
  • PCOS
  • ovarian cancer

Languages

  • English (Fluent)

Fields of Research

CodeDescriptionPercentage
060403Developmental Genetics (incl. Sex Determination)20
111201Cancer Cell Biology50
111203Cancer Genetics30

Professional Experience

UON Appointment

DatesTitleOrganisation / Department
1/01/2015 - LecturerUniversity of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Journal article (17 outputs)

YearCitationAltmetricsLink
2014Tanwar PS, Mohapatra G, Chiang S, Engler DA, Zhang L, Kaneko-Tarui T, et al., 'Loss of LKB1 and PTEN tumor suppressor genes in the ovarian surface epithelium induces papillary serous ovarian cancer', CARCINOGENESIS, 35 546-553 (2014) [C1]
DOI10.1093/carcin/bgt357Author URL
CitationsScopus - 7Web of Science - 4
2013Tanwar PS, Kaneko-Tarui T, Lee H, Zhang L, Teixeira JM, 'PTEN loss and HOXA10 expression are associated with ovarian endometrioid adenocarcinoma differentiation and progression', Carcinogenesis, 34 893-901 (2013) [C1]

Epithelial ovarian cancer is a heterogeneous disease that is subdivided into five major histotypes but the mechanisms driving their differentiation are not clear. Mutations in adenomatous polyposis coli (APC) and ß-catenin are commonly observed in the human ovarian endometrioid adenocarcinoma (OEA) patients. However, the mechanisms subsequent to APC deletion in ovarian tumorigenesis have not been well characterized. We have conditionally deleted APC in the murine ovarian surface epithelium (OSE) and showed that its loss leads to development of epithelial inclusion cysts. High-grade OEAs with tightly packed villoglandular histology were observed in older APC-deleted mice. Phosphatase and tensin homolog (PTEN) expression was elevated in the early lesions but lost after progression to the more advanced tumors. Knockdown of APC or expression of a gain-of-function ß-catenin similarly induced human OSE cells to develop tumors with endometrioid histology in xenografts. Expression of HOXA10 was induced in both the advanced APC-deleted murine tumors and in the tumor xenografts of human OSE cells with knocked-down APC. These results show that reduced APC activity is sufficient to induce formation of epithelial inclusion cysts and support OEA development and suggest that induced HOXA10 expression and loss of PTEN are key mechanisms driving endometrioid histotype differentiation and progression. © The Author 2012.Published by Oxford University Press. All rights reserved.

DOI10.1093/carcin/bgs405
CitationsScopus - 6Web of Science - 5
2012Tanaka Y, Park JH, Tanwar PS, Kaneko-Tarui T, Mittal S, Lee H-J, Teixeira JM, 'Deletion of Tuberous Sclerosis 1 in Somatic Cells of the Murine Reproductive Tract Causes Female Infertility', ENDOCRINOLOGY, 153 404-416 (2012) [C1]
DOI10.1210/en.2011-1191Author URL
CitationsScopus - 12Web of Science - 11
2012Meirelles K, Benedict LA, Dombkowski D, Pepin D, Preffer FI, Teixeira J, et al., 'Human ovarian cancer stem/progenitor cells are stimulated by doxorubicin but inhibited by Mullerian inhibiting substance', PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109 2358-2363 (2012) [C1]
DOI10.1073/pnas.1120733109Author URL
CitationsScopus - 31Web of Science - 25
2012Tanwar PS, Commandeur AE, Zhang L, Taketo MM, Teixeira JM, 'The Mullerian inhibiting substance type 2 receptor suppresses tumorigenesis in testes with sustained beta-catenin signaling', CARCINOGENESIS, 33 2351-2361 (2012) [C1]
DOI10.1093/carcin/bgs281Author URL
CitationsScopus - 2Web of Science - 1
2012Tanwar PS, Kaneko-Tarui T, Zhang L, Teixeira JM, 'Altered LKB1/AMPK/TSC1/TSC2/mTOR signaling causes disruption of sertoli cell polarity and spermatogenesis', Human Molecular Genetics, 21 4394-4405 (2012) [C1]
CitationsScopus - 15Web of Science - 15
2012Tanwar PS, Kaneko-Tarui T, Zhang L, Tanaka Y, Crum CP, Teixeira JM, 'Stromal liver kinase B1 STK11 signaling loss induces oviductal adenomas and endometrial cancer by activating mammalian target of Rapamycin Complex 1', PLOS Genetics, 8 1-14 (2012) [C1]
CitationsScopus - 12Web of Science - 9
2011Tanwar PS, Zhang L, Kaneko-Tarui T, Curley MD, Taketo MM, Rani P, et al., 'Mammalian Target of Rapamycin Is a Therapeutic Target for Murine Ovarian Endometrioid Adenocarcinomas with Dysregulated Wnt/beta-Catenin and PTEN', PLOS ONE, 6 (2011) [C1]
DOI10.1371/journal.pone.0020715Author URL
CitationsScopus - 17Web of Science - 18
2011Tanwar PS, Zhang L, Roberts DJ, Teixeira JM, 'Stromal Deletion of the APC Tumor Suppressor in Mice Triggers Development of Endometrial Cancer', CANCER RESEARCH, 71 1584-1596 (2011) [C1]
DOI10.1158/0008-5472.CAN-10-3166Author URL
CitationsScopus - 23Web of Science - 18
2011Tanwar PS, Zhang L, Teixeira JM, 'Adenomatous Polyposis Coli (APC) Is Essential for Maintaining the Integrity of the Seminiferous Epithelium', MOLECULAR ENDOCRINOLOGY, 25 1725-1739 (2011) [C1]
DOI10.1210/me.2011-0057Author URL
CitationsScopus - 12Web of Science - 11
2011Tanwar PS, McFarlane JR, 'Dynamic expression of bone morphogenetic protein 4 in reproductive organs of female mice', REPRODUCTION, 142 573-579 (2011) [C1]
DOI10.1530/REP-10-0299Author URL
CitationsScopus - 9Web of Science - 9
2010Tanwar PS, Kaneko-Tarui T, Zhang L, Rani P, Taketo MM, Teixeira J, 'Constitutive WNT/Beta-Catenin Signaling in Murine Sertoli Cells Disrupts Their Differentiation and Ability to Support Spermatogenesis', BIOLOGY OF REPRODUCTION, 82 422-432 (2010) [C1]
DOI10.1095/biolreprod.109.079335Author URL
CitationsScopus - 43Web of Science - 41
2010Tanwar PS, Zhang L, Tanaka Y, Taketo MM, Donahoe PK, Teixeira JM, 'Focal Mullerian duct retention in male mice with constitutively activated beta-catenin expression in the Mullerian duct mesenchyme', PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 107 16142-16147 (2010) [C1]
DOI10.1073/pnas.1011606107Author URL
CitationsScopus - 10Web of Science - 10
2009Tanwar PS, Lee H-J, Zhang L, Zukerberg LR, Taketo MM, Rueda BR, Teixeira JM, 'Constitutive Activation of Beta-Catenin in Uterine Stroma and Smooth Muscle Leads to the Development of Mesenchymal Tumors in Mice', BIOLOGY OF REPRODUCTION, 81 545-552 (2009) [C1]
DOI10.1095/biolreprod.108.075648Author URL
CitationsScopus - 40Web of Science - 36
2009Viswanathan SR, Powers JT, Einhorn W, Hoshida Y, Ng TL, Toffanin S, et al., 'Lin28 promotes transformation and is associated with advanced human malignancies', NATURE GENETICS, 41 843-U109 (2009) [C1]
DOI10.1038/ng.392Author URL
CitationsScopus - 323Web of Science - 303
2008Wu X, Tanwar PS, Raftery LA, 'Drosophila follicle cells: Morphogenesis in an eggshell', SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 19 271-282 (2008) [C1]
DOI10.1016/j.semcdb.2008.01.004Author URL
CitationsScopus - 46Web of Science - 47
2008Wu X, Yamada-Mabuchi M, Morris EJ, Tanwar PS, Dobens L, Gluderer S, et al., 'The Drosophila homolog of human tumor suppressor TSC-22 promotes cellular growth, proliferation, and survival', PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 105 5414-5419 (2008) [C1]
DOI10.1073/pnas.0800945105Author URL
CitationsScopus - 13Web of Science - 11
Show 14 more journal articles

Conference (9 outputs)

YearCitationAltmetricsLink
2014Kumar M, Sahoo SS, Tanwar P, 'MTOR: A NOVEL TARGET FOR TESTICULAR CANCER', ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, Newcastle, NSW (2014) [E3]
Author URL
2014Tanwar PS, Kaneko-Tarui T, Teixeira JM, 'Constitutive Wnt/B-Catenin Signaling in Mice in the Absence of Mullerian Inhibiting Substance/AntiMulleiran Hormone Signaling Leads to the Development of a Polycystic Ovary Phenotype', REPRODUCTIVE SCIENCES (2014) [E3]
Author URL
2013Tanwar PS, 'Frequent alterations in mTOR signaling in human ovarian serous carcinomas', 25th Lorne Cancer Conference, Lorne, Victoria, Australia (2013) [E3]
2013Tanwar PS, 'The Müllerian Inhibiting Substance type 2 receptor is an endogenous tumor suppressor and its loss phenocopies PTEN loss or activation of Kras in testes with sustained ßcatenin signaling', Society of Reproductive Biology Endocrine Society of Australia Annual Scientific Meeting, Sydney, NSW, Australia (2013) [E3]
2013Tanwar PS, 'Preclinical models of ovarian cancer: PI3K-mTOR signalling axis', Translational Cancer Research Conference, Newcastle, NSW, Australia (2013) [E3]
2011Tanwar PS, Zhang L, Teixeira J, 'APC (Adenomatous Polyposis Coli), a Tumor Suppressor Gene, Is Required for Maintenance of Sertoli Cell Polarity and Microtubules Integrity.', BIOLOGY OF REPRODUCTION, Portland, OR (2011) [E3]
Author URL
2010Tanwar PS, Zhang L, Tanaka Y, Taketo MM, Donahoe PK, Teixeira J, 'Mullerian Mesenchyme-Specific Activation of Wnt/Beta-Catenin Signaling Inhibits Mullerian Duct Regression and Contributes to Male Infertility', BIOLOGY OF REPRODUCTION, Milwaukee, WI (2010) [E3]
Author URL
2010Tanaka Y, Park JH, Tanwar PS, Kaneko-Tarui T, Mittal S, Teixeira J, 'DELETION OF TSC1 IN OVARIAN SOMATIC CELLS OF THE FEMALE REPRODUCTIVE TRACT CAUSES INFERTILITY.', FERTILITY AND STERILITY, Denver, CO (2010) [E3]
Author URL
2009Tanwar PS, Kaneko-Tarui T, Zhang L, Rani P, Taketo MM, Teixeira J, 'Progressive Spermatogonial Stem Cell Loss in Mice with Constitutively Activated Beta-Catenin in Postpubertal Sertoli Cells is Associated with Persistent Expression or GDNF and MIS.', BIOLOGY OF REPRODUCTION, Pittsburgh, PA (2009) [E3]
Author URL
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Grants and Funding

Summary

Number of grants11
Total funding$2,098,905

Click on a grant title below to expand the full details for that specific grant.


20153 grants / $900,695

Targeting chemoresistant ovarian cancer cells$508,396

Funding body: Cancer Institute NSW

Funding bodyCancer Institute NSW
Project TeamDoctor Pradeep Tanwar
SchemeCareer Development Fellowship
RoleLead
Funding Start2015
Funding Finish2015
GNoG1400754
Type Of FundingOther Public Sector - State
Category2OPS
UONY

Contribution of ovarian cancer stem cells to chemoresistance and recurrent disease.$367,077

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamDoctor Pradeep Tanwar
SchemeProject Grant
RoleLead
Funding Start2015
Funding Finish2015
GNoG1400046
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Uterine fibroids: Molecular basis of pathogenesis of uterine leiomyoma$25,222

Funding body: John Hunter Hospital Charitable Trust Fund

Funding bodyJohn Hunter Hospital Charitable Trust Fund
Project TeamDoctor Pradeep Tanwar, Doctor Pravin Nahar
SchemeResearch Grant
RoleLead
Funding Start2015
Funding Finish2015
GNoG1500010
Type Of FundingOther Public Sector - State
Category2OPS
UONY

20142 grants / $61,500

DVC(R) Research Support for Future Fellow (FT13)$60,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Pradeep Tanwar
SchemeSpecial Project Grant
RoleLead
Funding Start2014
Funding Finish2014
GNoG1301419
Type Of FundingInternal
CategoryINTE
UONY

Transforming Women's Health via Translational Investigation, Florence Italy, 26-29 March 2014$1,500

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding bodyUniversity of Newcastle - Faculty of Health and Medicine
Project TeamDoctor Pradeep Tanwar
SchemeTravel Grant
RoleLead
Funding Start2014
Funding Finish2014
GNoG1400204
Type Of FundingInternal
CategoryINTE
UONY

20135 grants / $844,410

mTOR signalling in serous ovarian cancer$749,814

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamDoctor Pradeep Tanwar
SchemeFuture Fellowships
RoleLead
Funding Start2013
Funding Finish2013
GNoG1300140
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

High Resolution Triple Fluorescence Stereomicroscope$30,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamDoctor Pradeep Tanwar
SchemeEquipment Grant
RoleLead
Funding Start2013
Funding Finish2013
GNoG1301311
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

Role of Wnt-P13K-mTOR signalling reproductive functions and gynecology/genitourinary cancers$5,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Pradeep Tanwar
SchemeNew Staff Grant
RoleLead
Funding Start2013
Funding Finish2013
GNoG1300983
Type Of FundingInternal
CategoryINTE
UONY

20121 grants / $292,300

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Research Supervision

Current Supervision

CommencedResearch Title / Program / Supervisor Type
2015Understanding the Development of Ovarian Granulosa Cell Cancer Using a Mouse Model with Mutation in APC Gene in Granulosa Cells
Medical Science, Faculty of Health and Medicine
Principal Supervisor
2015Investigating Novel Co-molecular Lesions of TP-53 in Serous Adeno Carcinomas and Their Role in DNA Damage
Medical Science, Faculty of Health and Medicine
Principal Supervisor
2015Biomarkers for Circulating Ovarian Cancer Cells: A Prognostic and Therapeutic Approach
Medical Science, Faculty of Health and Medicine
Principal Supervisor
2014To Investigate the Interaction of Bone Marrow Derived Endothelial Progenitor Cells (EPCs) with Ovarian Cancer Stem Cells (CSCs) in Tumor Angiogenesis Invasion
Medical Science, Faculty of Health and Medicine
Principal Supervisor
2014Investigating Genetic Alteration in Pathogenesis of Urine Endometrial Cancers
Medical Science, Faculty of Health and Medicine
Principal Supervisor
2014WNT Signaling in Uterine Cancer
Medical Science, Faculty of Health and Medicine
Principal Supervisor
2013Role of Wnt Signalling in Testicular Morphogenesis and Carcinogenesis
Medical Science, Faculty of Health and Medicine
Principal Supervisor
2013Role of Wnt Signalling in Endometrial Homeostasis and Cancer
Medical Science, Faculty of Health and Medicine
Principal Supervisor
2013Endometrial Stem/Progenitor Cells in Endometrial Regeneration, Carcinogenesis and Aging
Medical Science, Faculty of Health and Medicine
Principal Supervisor
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News

Dr Pradeep Tanwar

New approach to chemo-resistant ovarian cancer

March 12, 2015

Dr Pradeep Tanwar is working on a protein that has the potential to treat chemotherapy-resistant ovarian cancer.

Dr Mark Lock

$8.8M ARC funding

November 8, 2013

The Australian Research Council (ARC) has today awarded $8.8 million in Discovery Project research funding to the University of Newcastle. The funding will extend across 19 projects, an increase of 6 projects and $4.2 million since last year.

Dr Pradeep Tanwar

Position

ARC Future Fellow
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

Focus area

Medical Biochemistry

Contact Details

Emailpradeep.tanwar@newcastle.edu.au
Phone(02) 4921 5148

Office

RoomLS2-36
BuildingLife Sciences Building: 236
LocationCallaghan
University Drive
Callaghan, NSW 2308
Australia
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