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Professor Phil Hansbro

Professor, NHMRC Fellow and Brawn Fellow

School of Biomedical Sciences and Pharmacy (Immunology and Microbiology)

Of mice and mending

Professor Phil Hansbro is unconventional but effective, employing a number of experimental mouse models to investigate – and manipulate – the hallmark features of respiratory disease.

Professor Phil HansbroHansbro's plan of attack on the diseases of our airways is quite simple – understand their pathogenesis to identify new avenues of therapy. Equal parts scientific and artistic, the ambitious academic's two-pronged approach is recognised internationally as a valuable, ongoing contribution to the field, affording researchers the opportunity to dissect and study the intricate architecture of multiple chronic inflammation disorders.

'Examining their development in humans is expensive and labour intensive,' he concedes.

'People can smoke for 10, 25, 50 years before they get emphysema.'

'Inducing them in laboratory mice, which are inbred and so identical, means that our work is well controlled.'

'We can be specific about the things we test for and find.'

The integration of molecular biology theory and practice, these novel models allow Hansbro and his team to explore respiratory disease and infection from several cellular angles. With expertise and particular emphasis on immunity, physiology and lung function analysis, their simulations of key pathogenic events excite those both in and out of the laboratory.

'Our research outcomes have a translational goal,' Hansbro explains.

'We aim to show that what we discover is important for human diseases too.'

Similarly acknowledging the importance of sticking to a realistic timeframe, the Hunter Medical Research Institute innovator employs both short-term and long-term studies.

'We're focused on identifying potential treatments for severe asthma and chronic obstructive pulmonary disease (COPD), also known as emphysema,' he declares. 

'Existing treatments only partially suppress exacerbations and some don't work at all.' 

'Sufferers are more susceptible to respiratory infections too, so we need to work out why this is and find ways to manage them – or better yet – prevent this co-morbidity altogether.'

Dynamic networks

Taking a 'very roundabout route' to get to this point, Hansbro began his research career in organic chemistry. The English native completed a PhD in the discipline at the University of Leeds in the early 90s, principally using it to investigate intracellular signalling pathways relevant to cancer.

'This involved isolating enzymes and using them to make compounds to produce biomembranes that release molecules, which when over-produced, are important in cancer,' he instructs.

The energetic scholar then headed across the ocean to Australia to undertake post-doctoral studies into protein biochemistry.  Also involving elements of microbiology and molecular biology, this endeavour inspired a widening of research fields and goals.

'This allowed us to explore the functions of these and other enzymes and molecules involved in muscle disease and respiration in some depth,' he states.

After these studies he moved back to England, taking up residency at the University of Cambridge in 1997 to design and test new vaccines against infection with the bacteria Streptococcus pneumoniae. The three-year appointment proved to be a mix of new and old for Hansbro, piquing his scientific curiosity in airway inflammation while also enabling him to continue using a range of microbiological and molecular techniques.

'Streptococcus pneumoniae is a major respiratory pathogen,' he reveals.

'It is the commonest cause of pneumonia and is also an important inducer of meningitis, blood and ear infections.'

Hansbro continued exploring the pathogenic bacterium after being recruited to the University of Newcastle, Australia, in the late 90s, impressively identifying a number of factors that protect against asthma. Developing them into therapeutic strategies for the last 15 years, the research leader is set to go into clinical trials with them 'some time' in 2015.

Gut reaction

In a simultaneous attempt to produce novel treatments for other respiratory diseases, Hansbro is conducting an extensive series of studies of the lower respiratory tract. The immunologist is investigating the role of inflammatory features and immune cells involved in the disease and is hoping his studies will help firm up understanding of the pathogenesis of COPD.

'In some experiments we're trying to determine the bacterial changes that occur in the lung and gut during the development of COPD,' he clarifies.

'So far we've found that smoking can alter the bacteria that make up the microbiome in the gut.'

'It also might be possible to 'drown out' emphysema-related bacteria using faecal transplants.'

Comically labelled 'transpoosion,' the unsavoury science involves taking faeces from healthy mice and putting them in the guts of those with COPD. No laughing matter though, this 'repoopulation' remedy may treat the symptoms of the disorder and/or protect against its development.

'We're in the process of studying bacteria that may be involved and discovering exactly what they do and what they are,' Hansbro divulges.

'The idea is that we'll eventually be able to develop new antibiotics or other therapies against them.'

Damage control

A master of many disciplines, Hansbro is concurrently running an experimental trial of epigenetic inhibitors. Acknowledging the increased production of inflammatory genes when people are overexposed to smoke and air pollution, the esteemed educator and investigator is looking to find ways to prevent harmful DNA modifications from occurring.

'Nicotine-induced acetylation causes DNA to unravel, which means it opens up more and allows enzymes to generate greater amounts of these genes,' he explains.

'We're looking at ways of stopping this in mice.'

'Then we can try to work out precisely how the inhibitors suppress disease.'

Exploring the possibilities of therapeutic gene silencing inherent in another form of epigenetics, Hansbro is also in the middle of specifying the function of microRNAs. Once thought to be junk byproducts of RNA, these small pieces are now widely thought to serve as on/off switches for inflammation.

'Some of them potentially target and destroy anti-inflammatory factors,' he claims.

'Knowing exactly how and why they're implicated in respiratory disease will help us to develop effective inhibitors.'

With oxidative stress from smoking similarly linked to pro-inflammatory environments, Hansbro is undertaking a research project on cellular respiration as well.

'We need to work out how mitochondria become altered to produce it,' he asserts.  

'Then we can develop inhibitors.'

Two diseases, one knockout blow

Other new therapeutic targets for COPD are being imagined using a system of elimination, with Hansbro and his team 'knocking out' a number of genes in mast cells to infer probable function and identify novel roles. Observing physiological variances between wild mice and the mice that are deficient in particular factors, their current research implicates mast cells as pathological mediators of several inflammatory conditions.

'Our recent studies show knocking out two different genes causes the mice to get less COPD,' he affirms.

'This tells us how important they are in the disorder.'  

Hansbro is also using the mice to explore and understand the pathogenesis of lung cancer. One-upping previous experimental models of the disease, which induce lung cancer in tissues in 9 months, the expert has got it down to just sixteen weeks.

'But we're hoping to cut that time in half,' he shares.

'We can find good treatments for lung cancer if we're aware of how it develops.'

The next phase

 Set to translate this research into practice, Hansbro is looking forward to applying his therapies to humans.

'Proving their effectiveness takes a long time,' he admits.

'Once we're sure, we can start exposing our own respiratory cells to allergens or cigarette smoke and using the treatments to suppress elevated inflammatory responses.'

The Associate Director of the University's Priority Research Centre for Asthma and Respiratory Disease is similarly looking forward to celebrating the achievements of his young collaborators at the Hunter Medical Research Institute.

'We really believe in our students and early career researchers,' he avows.

'They're the next generation of scientists.'

Professor Phil Hansbro

Of mice and mending

and infections and is developing interests in lung cancer.

Read more

Career Summary

Biography

Professor Phil Hansbro is an internationally recognised research leader in the study of respiratory diseases, such as asthma, chronic obstructive airway disease (COPD, aka emphysema) and infections and is developing interests in lung cancer. His work is substantially contributing to understanding the pathogenesis and developing new therapies for these diseases. Indeed his work has made internationally important contributions and led to the identification of novel avenues for therapy that are under further study. This is achieved through the development of novel mouse models that recapitulate the hallmark features of human disease, including infections, asthma and COPD and now lung cancer. He employs these models in integrated approaches (infection, immunity & physiology with particular expertise in lung function analysis) to understand human diseases, and develop new treatment strategies. Research outcomes have a translational goal and his studies are conducted in parallel with collaborative human studies with clinical researchers. Major achievements:

1. Identified that the age, timing and nature of infection is critical in determining effects on asthma.

2. Determined that Chlamydia infection induces severe asthma in early life and adults.

3. Showed that combination of Haemophilus influenzae or Chlamydia respiratory infection and asthma drives a severe steroid-resistant asthma phenotype and chronic infection in adults.

4. Showed that Streptococcus pneumoniae exposure is protective against asthma.

5. Identified potential novel asthma therapeutic strategies that either target or utilise bacteria.

6. Created a short-term mouse model of COPD with the hallmark features of the human disease.

7. Identified novel roles for mast cell tryptases in experimental COPD.

8. Demonstrated critical roles for constitutive IFN responses and viral proteins in influenza.

9. Discovered that a new interferon, IFNε, protects against Chlamydia reproductive tract infection.

10. Developed a novel model of lung cancer that is induced by cigarette smoke.

11. He is also an expert in the study of avian influenza viruses (AIVs) in wild birds and to date his group has collected over 240,000 samples and identified ~250 AIVs.

His group has been recognized by the award of numerous nationally competitive grants, particularly from the NHMRC. Since 2004 he has published ~100 peer reviewed journal articles, with an average impact factor of 5+. These include publications in the leading general (Science [IF=31], Nature Immunology [IF=26]), respiratory (Am J Respir Crit Care Med [IF=12]), allergy (J Allergy Clin Immunol [IF=11]), infection (PLoS Pathog [IF=9]) and immunology journals (J Immunol [IF=6]). He is frequently invited to write reviews in prestigious journals (Pharmacol Ther [IF=8.0], Am J Respir Cell Mol Biol [IF=4.5], Immunology [IF=3.4]), which make substantial contributions to the fields. He is a regular reviewer for national granting bodies and leading international journals.

Prof Hansbro has a high level record of achievement & performance as a research leader recognised by high level appointments (Deputy director of the Centre for Asthma & Respiratory Disease (CARD) & the CRC for Asthma & Airways [CRCAA, UoN 2005-12], Head, Discipline of Immunology & Microbiology [2007-11], joint leader of Infection & Immunity Research Cluster, Director of School Research Committee). These Centres & Groups are internationally recognised for contributions to respiratory & infectious diseases. With Profs P. Foster & P. Gibson has built an internationally recognised, world leading research program with a reputation for excellence in respiratory research; CARD, with state-of-the-art facilities for the study of infection, immunity, histology, respiratory physiology & function.

Research Expertise
Expertise in the inevstigation of the relationship between bacterial and viral infections and obstructive airway diseases such as asthma and COPD. Expertise in the collection and analysis of avian influenza viruses from wild birds.

Teaching Expertise
Extensive undergraduate and postgraduate teaching experience into a wide variety of courses using teh full range of educational tools. Particular expertise in teaching Biomedical Sciences, Medicine, Nursing.

Administrative Expertise
Extensive expertise and experience in University administration and governance. head of Discipline of Immunology & Microbiology, Deputy Head of School of bIomedical Sciences Research Committee and various teaching administration bodies.



Qualifications

  • PhD, University of Leeds - UK
  • Bachelor of Science (Honours), Hallamshire University

Keywords

  • Allergy
  • Asthma
  • Avian influenza
  • Bacteriology
  • COPD
  • Epigenetics
  • Immunology
  • Infectious diseases
  • Inflammasome
  • Inflammation
  • Lung cancer
  • Microbiology
  • Microbiome
  • Reproductive tract diseases
  • Respiratory diseases
  • Virology

Fields of Research

CodeDescriptionPercentage
110299Cardiorespiratory Medicine and Haematology not elsewhere classified25
110799Immunology not elsewhere classified75

Professional Experience

UON Appointment

DatesTitleOrganisation / Department
1/01/2015 - ProfessorUniversity of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
25/03/2013 - 19/06/2013Casual LecturerUniversity of Newcastle
School of Biomedical Sciences and Pharmacy
Australia

Academic appointment

DatesTitleOrganisation / Department
Head - Discipline of Immunology & MicrobiologyUniversity of Newcastle
Australia
Co-director Infection and Immunity Research ClusterUniversity of Newcastle
School of Biomedical Sciences
Australia
Deputy Program Leader - Priority Research Centre for Asthma and Airways, UNEWUniversity of Newcastle
Australia
1/07/2011 - ProfessorUniversity of Newcastle
Immunology & Microbiology
Australia
1/07/2007 - 1/06/2011Associate ProfessorUniversity of Newcastle
Immunology & Microbiology
Australia
1/01/2007 - Head of Discipline of Immunology & MicrobiologyUniversity of Newcastle
Australia
1/01/2005 - 31/12/2007Organiser and Convenor - Newcastle Asthma MeetingUniversity of Newcastle
Australia
1/01/2005 - 1/06/2007Senior LecturerUniversity of Newcastle
Immunology & Microbiology
Australia
1/10/1999 - Group leader Microbiology Research GroupUniversity of Newcastle
Australia
1/10/1999 - 1/12/2004Lecturer in MicrobiologyUniversity of Newcastle
Australia
1/10/1999 - 1/12/2004LecturerUniversity of Newcastle
Immunology & Microbiology
Australia

Membership

DatesTitleOrganisation / Department
Membership - School of Biomedical Sciences ExecutiveUniversity of Newcastle
Australia
Member - Organising Committee of the International Symposium on Pneumococci and Pneumococcal DiseasesOrganising Committee of the International Symposium on Pneumococci and Pneumococcal Diseases
Australia
Invited Academic Member - Nuways Committee for Streamlining Research ProcessesUniversity of Newcastle
Deputy HeadSchool of Biomedical Sciences Research Committee
Australia
External Member - Mater Hospital Grant Review PanelMater Hospital Grant Review Panel
Australia
Member - National Avian Influenza Stearing CommitteeNational Avian Influenza Stearing Committee
Australia
Member - NHMRC Grant Review Panel (GRP2e inflammation)NHMRC Grant Review Panel
Australia
Associate Director - Priority Research Centre for Asthma and Airways, UNEWUniversity of Newcastle
Australia
Representative of UNEW and HMRI nodes - CRC for Asthma and Airways Education CommitteeCRC for Asthma and Airways
Australia

Awards

Research Award

YearAward
2005Brawn fellowship
University of Newcastle
2002Leo Dintenfass Award
Rebecca L Cooper Medical Research Foundation Ltd

Invitations

External Reviewer - Programs

YearTitle / Rationale
2006 research grants review panel
Organisation: Mater Hospital Description: research leader

Participant

YearTitle / Rationale
2007CRC for asthma and airways
Organisation: CRC for asthma and airways Description: Contribution to asthma research
2006Influenza symposium
Organisation: Influenza symposium Description: Ledaer in bird flu research
2006National avian influenza conference
Organisation: National avian influenza conference Description: Leader in influenza research
2006Various including Asthma Think tank and a variety of other invited talks at departments and conferences
Organisation: Many Description: Resaerch leader in asthma
2006CRC for asthma and airways
Organisation: CRC for asthma and airways Description: Contribution to asthma research
2005CRC for asthma and airways
Organisation: CRC for asthma and airways Description: Contribution to asthma research
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Chapter (3 outputs)

YearCitationAltmetricsLink
2014Hsu A, Zhong H, Hansbro P, Wark P, 'Innate Immunity in the Airways to Respiratory Viruses', Virology II - Advanced Issues, iConcept Press, Hong Kong 1-32 (2014) [B1]
Author URL
Co-authorsAlan Hsu, Peter Wark
2014Hsu A, Loo S, Fathi Aghdam F, Parsons K, Hansbro P, Wark P, 'Airway Epithelial and Early Innate Immune Responses to Virus Infections', Human Respiratory Viral Infections, CRC Press, Boca Raton, FL 29-44 (2014) [B1]
DOI10.1201/b16778-5Author URL
Co-authorsAlan Hsu, Peter Wark
2010Hansbro PM, 'Migratory birds at Hunter Valley Gardens', Beautiful Birds: From Hunter Valley Gardens, Panographs Publishing, Wamberal, NSW 47 (2010) [B2]

Journal article (129 outputs)

YearCitationAltmetricsLink
2015Jones B, Jarnicki A, Smithers N, Knight D, Wark P, Adcock I, Hansbro P, 'EPIGENETIC CHANGES IN HATS AND HDACS DRIVE PATHOGENESIS THAT CAN BE REVERSED USING BET INHIBITORS IN EXPERIMENTAL COPD', RESPIROLOGY, 20 30-30 (2015)
Author URL
2015Tang F, Hansbro P, Burgess J, Baines K, Oliver B, 'NEUTROPHILS DISPLAY IMMUNOREGULATORY ROLES IN RHINOVIRUS INFECTIONS', RESPIROLOGY, 20 128-128 (2015)
Author URL
2015Vanders RL, Murphy VE, Gibson PG, Hansbro PM, Wark PAB, 'CD8 T cells and dendritic cells: Key players in the attenuated maternal immune response to influenza infection', Journal of Reproductive Immunology, 107 1-9 (2015)

Pregnancy provides a unique challenge for maternal immunity, requiring the ability to tolerate the presence of a semi-allogeneic foetus, and yet still being capable of inducing an immune response against invading pathogens. To achieve this, numerous changes must occur in the activity and function of maternal immune cells throughout the course of pregnancy. Respiratory viruses take advantage of these changes, altering the sensitive balance of maternal immunity, leaving the mother with increased susceptibility to viral infections and increased disease severity. Influenza virus is one of the most common respiratory virus infections during pregnancy, leading to an increased risk of ICU hospitalisations, pneumonia, acute respiratory distress syndrome and even death. Whilst much research has been performed to understand the changes that must take place in maternal immunity during pregnancy, considerable work is still needed to fully comprehend this tremendous feat. To date, few studies have focused on the alterations that occur in maternal immunity during respiratory virus infections. This review highlights the role of dendritic cells (DCs) and CD8 T cells during pregnancy, and the changes that occur in these antiviral cells following influenza virus infections.

DOI10.1016/j.jri.2014.09.051
Co-authorsPeter Gibson, Vanessa Murphy, Peter Wark
2015Zouikr I, Ahmed AF, Horvat JC, Beagley KW, Clifton VL, Ray A, et al., 'Programming of formalin-induced nociception by neonatal LPS exposure: Maintenance by peripheral and central neuroimmune activity', Brain, Behavior, and Immunity, 44 235-246 (2015)

The immune and nociceptive systems are shaped during the neonatal period where they undergo fine-tuning and maturation. Painful experiences during this sensitive period of development are known to produce long-lasting effects on the immune and nociceptive responses. It is less clear, however, whether inflammatory pain responses are primed by neonatal exposure to mild immunological stimuli, such as with lipopolysaccharide (LPS). Here, we examine the impact of neonatal LPS exposure on inflammatory pain responses, peripheral and hippocampal interleukin-1ß (IL-1ß), as well as mast cell number and degranulation in preadolescent and adult rats. Wistar rats were injected with LPS (0.05 mg/kg IP, Salmonella enteritidis) or saline on postnatal days (PNDs) 3 and 5 and later subjected to the formalin test at PNDs 22 and 80-97. At both time-points, and one-hour after formalin injection, blood and hippocampus were collected for measuring circulating and central IL-1ß levels using ELISA and Western blot, respectively. Paw tissue was also isolated to assess mast cell number and degree of degranulation using Toluidine Blue staining. Behavioural analyses indicate that at PND 22, LPS-challenged rats displayed enhanced flinching (p<.01) and licking (p<.01) in response to formalin injection. At PNDs 80-97, LPS-challenged rats exhibited increased flinching (p<.05), an effect observed in males only. Furthermore, neonatal LPS exposure enhanced circulating IL-1ß and mast cell degranulation in preadolescent but not adult rats following formalin injection. Hippocampal IL-1ß levels were increased in LPS-treated adult but not preadolescent rats in response to formalin injection. These data suggest neonatal LPS exposure produces developmentally regulated changes in formalin-induced behavioural responses, peripheral and central IL-1ß levels, as well as mast cell degranulation following noxious stimulation later in life. These findings highlight the importance of immune activation during the neonatal period in shaping immune response and pain sensitivity later in life. This is of clinical relevance given the high prevalence of bacterial infection during the neonatal period, particularly in the vulnerable population of preterm infants admitted to neonatal intensive care units.

DOI10.1016/j.bbi.2014.10.014
CitationsScopus - 1
Co-authorsRick Thorne, Jay Horvat, Deborah Hodgson
2015Hirota JA, Gold MJ, Hiebert PR, Parkinson LG, Wee T, Smith D, et al., 'The nucleotide-binding domain, leucine-rich repeat protein 3 inflammasome/IL-1 receptor I axis mediates innate, but not adaptive, immune responses after exposure to particulate matter under 10 µm', American Journal of Respiratory Cell and Molecular Biology, 52 96-105 (2015) [C1]

Exposure to particulate matter (PM), a major component of air pollution, contributes to increased morbidity and mortality worldwide. Inhaled PM induces innate immune responses by airway epithelial cells that may lead to the exacerbation or de novo development of airway disease. We have previously shown that 10-mm PM (PM10) activates the nucleotide-binding domain, leucine-rich repeat protein (NLRP) 3 inflammasome in human airway epithelial cells. Our objective was to determine the innate and adaptive immune responses mediated by the airway epithelium NLRP3 inflammasome in response to PM10 exposure. Using in vitro cultures of human airway epithelial cells and in vivo studies with wild-type and Nlrp3-/- mice, we investigated the downstream consequences of PM10-induced NLPR3 inflammasome activation on cytokine production, cellular inflammation, dendritic cell activation, and PM10-facilitated allergic sensitization. PM10 activates an NLRP3 inflammasome/IL-1 receptor I (IL-1RI) axis in airway epithelial cells, resulting in IL-1b, CC chemokine ligand-20, and granulocyte/macrophage colony-stimulating factor production, which is associated with dendritic cell activation and lung neutrophilia. Despite these profound innate immune responses in the airway epithelium, the NLRP3 inflammasome/IL-1RI axis is dispensable for PM10-facilitated allergic sensitization. We demonstrate the importance of the lung NLRP3 inflammasome in mediating PM10 exposure-associated innate, but not adaptive, immune responses. Our study highlights a mechanism by which PM10 exposure can contribute to the exacerbation of airway disease, but not PM10-facilitated allergic sensitization.

DOI10.1165/rcmb.2014-0158OC
Co-authorsDarryl Knight
2015Wark P, Tolosa J, Parsons K, Hansbro P, Smith R, 'THE PLACENTAL PROTEIN SYNCYTIN-1 IMPAIRS ANTIVIRAL RESPONSES AND EXAGGERATES INFLAMMATORY RESPONSES TO INFLUENZA', RESPIROLOGY, 20 28-28 (2015)
Author URL
Co-authorsRoger Smith
2015Hsu A, Parsons K, Hansbro P, Wark P, 'ENHANCED PI3K ACTIVITY LEADS TO DECREASED INTERFERON-beta RESPONSE TO INFLUENZA INFECTION IN COPD', RESPIROLOGY, 20 45-45 (2015)
Author URL
Co-authorsAlan Hsu
2015Loo S, Hsu A, Hansbro P, Wark P, 'THE ROLE OF PI3 KINASE IN INFLUENZA H1N1 AND RHINOVIRUS VIRAL ENTRY INTO PRIMARY BRONCHIAL EPITHELIAL CELLS', RESPIROLOGY, 20 128-128 (2015)
Author URL
Co-authorsAlan Hsu
2015Essilfie A-T, Horvat JC, Kim RY, Mayall JR, Pinkerton JW, Beckett EL, et al., 'Macrolide therapy suppresses key features of experimental steroid-sensitive and steroid-insensitive asthma', THORAX, 70 458-U151 (2015)
DOI10.1136/thoraxjnl-2014-206067Author URL
CitationsWeb of Science - 1
Co-authorsJay Horvat, Peter Gibson, Paul Foster, Malcolm Starkey, Jodie Simpson
2015Tay HL, Kaiko GE, Plank M, Li J, Maltby S, Essilfie AT, et al., 'Antagonism of miR-328 increases the antimicrobial function of macrophages and neutrophils and rapid clearance of non-typeable Haemophilus influenzae (NTHi) from infected lung.', PLoS pathogens, 11 e1004549 (2015)
DOI10.1371/journal.ppat.1004549
Co-authorsPaul Foster, Steven Maltby
2015Hirota JA, Gold MJ, Hiebert PR, Parkinson LG, Wee T, Smith D, et al., 'The Nucleotide-Binding Domain, Leucine-Rich Repeat Protein 3 Inflammasome/IL-1 Receptor I Axis Mediates Innate, but Not Adaptive, Immune Responses after Exposure to Particulate Matter under 10 mu m', AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 52 96-105 (2015) [C1]
DOI10.1165/rcmb.2014-0158OCAuthor URL
Co-authorsDarryl Knight
2015King PT, Sharma R, O'Sullivan K, Selemidis S, Lim S, Radhakrishna N, et al., 'Nontypeable Haemophilus influenzae Induces Sustained Lung Oxidative Stress and Protease Expression', PLOS ONE, 10 (2015)
DOI10.1371/journal.pone.0120371Author URL
2015Chen-Yu Hsu A, Starkey MR, Hanish I, Parsons K, Haw TJ, Howland LJ, et al., 'Targeting PI3K-p110a Suppresses Influenza Virus Infection in Chronic Obstructive Pulmonary Disease.', Am J Respir Crit Care Med, 191 1012-1023 (2015)
DOI10.1164/rccm.201501-0188OCAuthor URL
Co-authorsDarryl Knight, Peter Wark, Malcolm Starkey, Alan Hsu, Paul Foster
2015Baillet AC, Rehaume LM, Benham H, O'Meara CP, Armitage CW, Ruscher R, et al., 'High Chlamydia Burden Promotes Tumor Necrosis Factor-Dependent Reactive Arthritis in SKG Mice.', Arthritis Rheumatol, 67 1535-1547 (2015)
DOI10.1002/art.39041Author URL
2015Singanayagam A, Glanville N, Walton RP, Aniscenko J, Pearson RM, Pinkerton JW, et al., 'A short-term mouse model that reproduces the immunopathological features of rhinovirus-induced exacerbation of COPD.', Clin Sci (Lond), 129 245-258 (2015)
DOI10.1042/CS20140654Author URL
Co-authorsJay Horvat
2015Tolosa JM, Parsons KS, Hansbro PM, Smith R, Wark PA, 'The placental protein syncytin-1 impairs antiviral responses and exaggerates inflammatory responses to influenza.', PLoS One, 10 e0118629 (2015)
DOI10.1371/journal.pone.0118629Author URL
CitationsScopus - 1
Co-authorsPeter Wark, Roger Smith
2015Ge Q, Chen L, Jaffar J, Argraves WS, Twal WO, Hansbro P, et al., 'Fibulin1C peptide induces cell attachment and extracellular matrix deposition in lung fibroblasts.', Sci Rep, 5 9496 (2015)
DOI10.1038/srep09496Author URL
2014Starkey MR, Nguyen DH, Essilfie AT, Kim RY, Hatchwell LM, Collison AM, et al., 'Tumor necrosis factor-related apoptosis-inducing ligand translates neonatal respiratory infection into chronic lung disease.', Mucosal Immunol, 7 478-488 (2014) [C1]
DOI10.1038/mi.2013.65Author URL
CitationsScopus - 1
Co-authorsMalcolm Starkey, Joerg Mattes, Paul Foster, Jay Horvat
2014Franklin BS, Bossaller L, De Nardo D, Ratter JM, Stutz A, Engels G, et al., 'The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation.', Nat Immunol, 15 727-737 (2014) [C1]
DOI10.1038/ni.2913Author URL
CitationsScopus - 34Web of Science - 33
2014Olson SH, Parmley J, Soos C, Gilbert M, Latorre-Margalef N, Hall JS, et al., 'Sampling strategies and biodiversity of influenza A subtypes in wild birds', PLoS ONE, 9 (2014) [C1]

Wild aquatic birds are recognized as the natural reservoir of avian influenza A viruses (AIV), but across high and low pathogenic AIV strains, scientists have yet to rigorously identify most competent hosts for the various subtypes. We examined 11,870 GenBank records to provide a baseline inventory and insight into patterns of global AIV subtype diversity and richness. Further, we conducted an extensive literature review and communicated directly with scientists to accumulate data from 50 non-overlapping studies and over 250,000 birds to assess the status of historic sampling effort. We then built virus subtype sample-based accumulation curves to better estimate sample size targets that capture a specific percentage of virus subtype richness at seven sampling locations. Our study identifies a sampling methodology that will detect an estimated 75% of circulating virus subtypes from a targeted bird population and outlines future surveillance and research priorities that are needed to explore the influence of host and virus biodiversity on emergence and transmission.

DOI10.1371/journal.pone.0090826
CitationsScopus - 4Web of Science - 4
2014Grafton KT, Moir LM, Black JL, Hansbro NG, Hansbro PM, Burgess JK, Oliver BG, 'LF-15 & T7, synthetic peptides derived from tumstatin, attenuate aspects of airway remodelling in a murine model of chronic OVA-induced allergic airway disease', PLoS ONE, 9 (2014) [C1]

Background: Tumstatin is a segment of the collagen-IV protein that is markedly reduced in the airways of asthmatics. Tumstatin can play an important role in the development of airway remodelling associated with asthma due to its antiangiogenic properties. This study assessed the anti-angiogenic properties of smaller peptides derived from tumstatin, which contain the interface tumstatin uses to interact with the aVb3 integrin. Methods: Primary human lung endothelial cells were exposed to the LF-15, T3 and T7 tumstatin-derived peptides and assessed for cell viability and tube formation in vitro. The impact of the anti-angiogenic properties on airways hyperresponsiveness (AHR) was then examined using a murine model of chronic OVA-induced allergic airways disease. Results: The LF-15 and T7 peptides significantly reduced endothelial cell viability and attenuated tube formation in vitro. Mice exposed to OVA+ LF-15 or OVA+T7 also had reduced total lung vascularity and AHR was attenuated compared to mice exposed to OVA alone. T3 peptides reduced cell viability but had no effect on any other parameters. Conclusion: The LF-15 and T7 peptides may be appropriate candidates for use as novel pharmacotherapies due to their small size and anti-angiogenic properties observed in vitro and in vivo. © 2014 Grafton et al.

DOI10.1371/journal.pone.0085655
Co-authorsNicole Hansbro
2014Keely S, Hansbro PM, 'Lung-Gut Cross Talk A Potential Mechanism for Intestinal Dysfunction in Patients With COPD', CHEST, 145 199-200 (2014) [C3]
DOI10.1378/chest.13-2077Author URL
CitationsScopus - 1Web of Science - 1
Co-authorsSimon Keely
2014Jaffer J, Unger S, Corte TJ, Keller M, Wolters PJ, Richeldi L, et al., 'Fibulin-1 Predicts Disease Progression in Patients With Idiopathic Pulmonary Fibrosis', CHEST, 146 1055-1063 (2014) [C1]
DOI10.1378/chest.13-2688Author URL
CitationsWeb of Science - 1
2014Hansbro PM, Hamilton MJ, Fricker M, Gellatly SL, Jarnicki AG, Zheng D, et al., 'Importance of mast cell Prss31/transmembrane tryptase/tryptase-¿ in lung function and experimental chronic obstructive pulmonary disease and colitis', Journal of Biological Chemistry, 289 18214-18227 (2014) [C1]

Protease serine member S31 (Prss31)/transmembrane tryptase/tryptase-¿ is a mast cell (MC)-restricted protease of unknown function that is retained on the outer leaflet of the plasma membrane when MCs are activated. We determined the nucleotide sequences of the Prss31 gene in different mouse strains and then used a Cre/loxP homologous recombination approach to create a novel Prss31 -/- C57BL/6 mouse line. The resulting animals exhibited no obvious developmental abnormality, contained normal numbers of granulated MCs in their tissues, and did not compensate for their loss of the membrane tryptase by increasing their expression of other granule proteases. When Prss31-null MCs were activated with a calcium ionophore or by their high affinity IgE receptors, they degranulated in a pattern similar to that of WT MCs. Prss31-null mice had increased baseline airway reactivity to methacholine but markedly reduced experimental chronic obstructive pulmonary disease and colitis, thereby indicating both beneficial and adverse functional roles for the tryptase. In a cigarette smokeinduced model of chronic obstructive pulmonary disease, WT mice had more pulmonary macrophages, higher histopathology scores, and more fibrosis in their small airways than similarly treated Prss31-null mice. In a dextran sodium sulfate-induced acute colitis model, WT mice lost more weight, had higher histopathology scores, and contained more Cxcl-2 and IL-6 mRNA in their colons than similarly treated Prss31-null mice. The accumulated data raise the possibility that inhibitors of this membrane tryptase may provide additional therapeutic benefit in the treatment of humans with these MC-dependent inflammatory diseases. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

DOI10.1074/jbc.M114.548594
CitationsScopus - 4Web of Science - 3
Co-authorsMichael Fricker, Paul Foster
2014Chevalier N, Thorburn AN, Macia L, Tan J, Juglair L, Yagita H, et al., 'Inflammation and lymphopenia trigger autoimmunity by suppression of il-2-controlled regulatory t cell and increase of il-21-mediated effector t cell expansion', Journal of Immunology, 193 4845-4858 (2014) [C1]

The dynamic interplay between regulatory T cells (Tregs) and effector T cells (Teffs) governs the balance between tolerance and effector immune responses. Perturbations of Treg frequency and function or imbalances in Treg/Teff levels are associated with the development of autoimmunity. The factors that mediate these changes remain poorly understood and were investigated in this study in murine autoimmune arthritis. Tregs displayed a stable phenotype in arthritic mice and were fully functional in in vitro suppression assays. However, their expansion was delayed relative to Teffs (T follicular helper cells and Th17 cells) during the early stages of autoimmune reactivity. This imbalance is likely to have led to insufficient Treg control of Teffs and induced autoimmunity. Moreover, a counterregulatory and probably IL-7-driven increase in thymic Treg production and recruitment to inflamed tissues was too slow for disease prevention. Increased Teff over Treg expansion was further aggravated by inflammation and lymphopenia. Both these conditions contribute to autoimmune pathogenesis and were accompanied by decreases in the availability of IL-2 and increases in levels of IL-21. IL-2 neutralization or supplementation was used to show that Treg expansion mainly depended on this cytokine. IL-21R2/2 cells were used to demonstrate that IL-21 promoted the maintenance of Teffs. Thus, at inflammatory sites in experimental arthritis, a deficit in IL-2 hampers Treg proliferation, whereas exaggerated IL-21 levels overwhelm Treg control by supporting Teff expansion. This identifies IL-2 and IL-21 as targets for manipulation in therapies for autoimmunity.

DOI10.4049/jimmunol.1302966
2014McIlroy DJ, Jarnicki AG, Au GG, Lott N, Smith DW, Hansbro PM, Balogh ZJ, 'Mitochondrial DNA neutrophil extracellular traps are formed after trauma and subsequent surgery', Journal of Critical Care, 29 1133.e1-1133.e5 (2014)
DOI10.1016/j.jcrc.2014.07.013
Co-authorsGough Au, Zsolt Balogh, Douglas Smith
2014McIlroy DJ, Jarnicki AG, Au GG, Lott N, Smith DW, Hansbro PM, Balogh ZJ, 'Mitochondrial DNA neutrophil extracellular traps are formed after trauma and subsequent surgery', Journal of Critical Care, 29 1133.e1-1133.e5 (2014) [C1]

Introduction: Neutrophil extracellular traps (NETs) have not been demonstrated after trauma and subsequent surgery. Neutrophil extracellular traps are formed from pure mitochondrial DNA (mtDNA) under certain conditions, which is potently proinflammatory. We hypothesized that injury and orthopedic trauma surgery would induce NET production with mtDNA as a structural component. Methods: Neutrophils were isolated 8 trauma patients requiring orthopedic surgery postinjury and up to 5 days postoperatively. Four healthy volunteers provided positive and negative controls. Total hip replacement patients acted as an uninjured surgical control group. Neutrophil extracellular traps were visualized with DNA (Hoechst 33342TM/Sytox Green/MitoSox/MitoTracker) stains using live cell fluorescence microscopy with downstream quantitative polymerase chain reaction analysis of DNA composition. Results: Neutrophil extracellular traps were present after injury in all 8 trauma patients. They persisted for 5 days postoperatively. Delayed surgery resulted in NET resolution, but they reformed postoperatively. Total hip replacement patients developed NETs postoperatively, which resolved by day 5. Quantitative polymerase chain reaction analysis of NET-DNA composition revealed that NETs formed after injury and surgery were made of mtDNA with no detectable nuclear DNA component. Conclusions: Neutrophil extracellular traps formed after major trauma and subsequent surgery contain mtDNA and represent a novel marker of heightened innate immune activation. They could be considered when timing surgery after trauma to prevent systemic NET-induced inflammatory complications.

DOI10.1016/j.jcrc.2014.07.013
CitationsScopus - 3
Co-authorsGough Au, Douglas Smith, Zsolt Balogh
2014Prieto-García A, Castells MC, Hansbro PM, Stevens RL, 'Mast cell-restricted tetramer-forming tryptases and their beneficial roles in hemostasis and blood coagulation', Immunology and Allergy Clinics of North America, 34 263-281 (2014)
DOI10.1016/j.iac.2014.01.001
2014Prieto-García A, Castells MC, Hansbro PM, Stevens RL, 'Mast cell-restricted tetramer-forming tryptases and their beneficial roles in hemostasis and blood coagulation', Immunology and Allergy Clinics of North America, 34 263-281 (2014) [C1]

Tetramer-forming tryptase (hTryptase-ß) was recently discovered to have a prominent role in preventing the internal accumulation of life-threatening fibrin deposits and fibrin-platelet clots. The anticoagulant activity of hTryptase-ß is an explanation for the presence of hemorrhagic disorders in some patients with anaphylaxis or mastocytosis. The fragments of hFibrinogen formed by the proteolysis of this prominent protein by hTryptase-ß could be used as biomarkers in the blood and/or urine for the identification and monitoring of patients with mast cell-dependent disorders. Recombinant hTryptase-ß has potential to be used in clinical settings where it is desirable to inhibit blood coagulation. © 2014 Elsevier Inc.

DOI10.1016/j.iac.2014.01.001
CitationsScopus - 1Web of Science - 1
2014Hirota JA, Alexis NE, Pui M, Wong S, Fung E, Hansbro P, et al., 'PM10-stimulated airway epithelial cells activate primary human dendritic cells independent of uric acid: Application of an in vitro model system exposing dendritic cells to airway epithelial cell-conditioned media', Respirology, 19 881-890 (2014) [C1]

Background and objective Airway epithelial cells represent the first line of defence against inhaled insults, including air pollution. Air pollution can activate innate immune signalling in airway epithelial cells leading to the production of soluble mediators that can influence downstream inflammatory cells. Our objective was to develop and validate a model of dendritic cell exposure to airway epithelial cell-conditioned media. After establishing the model, we explored how soluble mediators released from airway epithelial cells in response to air pollution influenced the phenotype of dendritic cells. Methods Human airway epithelial cells were cultured under control and urban particulate matter (PM10) exposure conditions with or without pharmacological inhibitors of the uric acid pathway. Culture supernatants were collected for conditioned media experiments with peripheral blood mononuclear cell-derived dendritic cells analysed by flow cytometry. Results Monocytes derived from peripheral blood mononuclear cells cultured in interleukin-4 and granulocyte macrophage colony stimulating factor differentiated into immature dendritic cells that phenotypically differentiated into mature dendritic cells in response to conditioned media from phorbol myristate acetate-activated THP-1 monocytes. Exposure of immature dendritic cells to conditioned media from airway epithelial cells exposed to PM10 resulted in dendritic cell maturation that was independent of uric acid. Conclusions We present a conditioned media model useful for interrogating the contribution of soluble mediators produced by airway epithelial cells to dendritic cell phenotype and function. Furthermore, we demonstrate that PM10 exposure induces airway epithelial cell production of soluble mediators that induce maturation of dendritic cells independent of uric acid. We developed and validated a model of airway epithelial cell conditioned media exposure to primary human dendritic cells. Using this model, we then tested the hypothesis that urban particulate matter exposure to airway epithelial cells resulted in production of soluble mediators capable of inducing dendritic cell maturation. © 2014 Asian Pacific Society of Respirology.

DOI10.1111/resp.12316
CitationsScopus - 1Web of Science - 1
Co-authorsDarryl Knight
2014Hirota JA, Sin DD, Pui M, Wong S, Fung E, Carlsten C, et al., 'PM10-stimulated airway epithelial cells activate primary human dendritic cells independent of uric acid: Application of an in vitro model system exposing dendritic cells to airway epithelial cell-conditioned media', Respirology, 19 881-890 (2014)
DOI10.1111/resp.12316
Co-authorsDarryl Knight
2014Hallstrand TS, Hackett TL, Altemeier WA, Matute-Bello G, Hansbro PM, Knight DA, 'Airway epithelial regulation of pulmonary immune homeostasis and inflammation', Clinical Immunology, 151 1-15 (2014) [C1]

Recent genetic, structural and functional studies have identified the airway and lung epithelium as a key orchestrator of the immune response. Further, there is now strong evidence that epithelium dysfunction is involved in the development of inflammatory disorders of the lung. Here we review the characteristic immune responses that are orchestrated by the epithelium in response to diverse triggers such as pollutants, cigarette smoke, bacterial peptides, and viruses. We focus in part on the role of epithelium-derived interleukin (IL)-25, IL-33 and thymic stromal lymphopoietin (TSLP), as well as CC family chemokines as critical regulators of the immune response. We cite examples of the function of the epithelium in host defense and the role of epithelium dysfunction in the development of inflammatory diseases. © 2013 Elsevier Inc.

DOI10.1016/j.clim.2013.12.003
CitationsScopus - 15Web of Science - 15
Co-authorsDarryl Knight
2014Fricker M, Deane A, Hansbro PM, 'Animal models of chronic obstructive pulmonary disease', Expert Opinion on Drug Discovery, 9 629-645 (2014) [C1]

Introduction: Chronic obstructive pulmonary disease (COPD) is a leading global cause of mortality and chronic morbidity. Inhalation of cigarette smoke is the principal risk factor for development of this disease. COPD is a progressive disease that is typically characterised by chronic pulmonary inflammation, mucus hypersecretion, airway remodelling and emphysema that collectively reduce lung function. There are currently no therapies that effectively halt or reverse disease progression. It is hoped that the development of animal models that develop the hallmark features of COPD, in a short time frame, will aid in the identifying and testing of new therapeutic approaches. Areas covered: The authors review the recent developments in mouse models of chronic cigarette smoke-induced COPD as well as the principal findings. Furthermore, the authors discuss the use of mouse models to understand the pathogenesis and the contribution of infectious exacerbations. They also discuss the investigations of the systemic co-morbidities of COPD (pulmonary hypertension, cachexia and osteoporosis). Expert opinion: Recent advances in the field mark a point where animal models recapitulate the pathologies of COPD patients in a short time frame. They also reveal novel insights into the pathogenesis and potential treatment of this debilitating disease. © 2014 Informa UK, Ltd.

DOI10.1517/17460441.2014.909805
CitationsScopus - 5Web of Science - 6
Co-authorsMichael Fricker
2014Simpson JL, Powell H, Baines KJ, Milne D, Coxson HO, Hansbro PM, Gibson PG, 'The Effect of Azithromycin in Adults with Stable Neutrophilic COPD: A Double Blind Randomised, Placebo Controlled Trial', PLOS ONE, 9 (2014) [C1]
DOI10.1371/journal.pone.0105609Author URL
CitationsScopus - 3Web of Science - 1
Co-authorsPeter Gibson, Katherine Baines, Jodie Simpson
2014O'Reilly M, Hansbro PM, Horvat JC, Beckett EL, Harding R, Sozo F, 'Bronchiolar Remodeling in Adult Mice Following Neonatal Exposure to Hyperoxia: Relation to Growth', Anatomical Record, 297 758-769 (2014) [C1]

Preterm infants who receive supplemental oxygen for prolonged periods are at increased risk of impaired lung function later in life. This suggests that neonatal hyperoxia induces persistent changes in small conducting airways (bronchioles). Although the effects of neonatal hyperoxia on alveolarization are well documented, little is known about its effects on developing bronchioles. We hypothesized that neonatal hyperoxia would remodel the bronchiolar walls, contributing to altered lung function in adulthood. We studied three groups of mice (C57BL/6J) to postnatal day 56 (P56; adulthood) when they either underwent lung function testing or necropsy for histological analysis of the bronchiolar wall. One group inhaled 65% O2 from birth until P7, after which they breathed room air; this group experienced growth restriction (HE+GR group). We also used a group in which hyperoxia-induced GR was prevented by dam rotation (HE group). A control group inhaled room air from birth. At P56, the bronchiolar epithelium of HE mice contained fewer Clara cells and more ciliated cells, and the bronchiolar wall contained ~25% less collagen than controls; in HE+GR mice the bronchiolar walls had ~13% more collagen than controls. Male HE and HE+GR mice had significantly thicker bronchiolar epithelium than control males and altered lung function (HE males: greater dynamic compliance; HE+GR males: lower dynamic compliance). We conclude that neonatal hyperoxia remodels the bronchiolar wall and, in adult males, affects lung function, but effects are altered by concomitant growth restriction. Our findings may partly explain the reports of poor lung function in ex-preterm children and adults. Anat Rec, 297:758-769, 2014. © 2014 Wiley Periodicals, Inc.

DOI10.1002/ar.22867
CitationsWeb of Science - 1
Co-authorsJay Horvat
2014O'Reilly M, Harding R, Sozo F, Hansbro PM, Horvat JC, Beckett EL, 'Bronchiolar Remodeling in Adult Mice Following Neonatal Exposure to Hyperoxia: Relation to Growth', Anatomical Record, 297 758-769 (2014)
DOI10.1002/ar.22867
Co-authorsJay Horvat
2014Keely S, Campbell EL, Baird AW, Hansbro PM, Shalwitz RA, Kotsakis A, et al., 'Contribution of epithelial innate immunity to systemic protection afforded by prolyl hydroxylase inhibition in murine colitis', Mucosal Immunology, 7 114-123 (2014) [C1]

Pharmacological stabilization of hypoxia-inducible factor (HIF) through prolyl hydroxylase (PHD) inhibition limits mucosal damage associated with models of murine colitis. However, little is known about how PHD inhibitors (PHDi) influence systemic immune function during mucosal inflammation or the relative importance of immunological changes to mucosal protection. We hypothesized that PHDi enhances systemic innate immune responses to colitis-associated bacteremia. Mice with colitis induced by trinitrobenzene sulfonic acid were treated with AKB-4924, a new HIF-1 isoform-predominant PHDi, and clinical, immunological, and biochemical endpoints were assessed. Administration of AKB-4924 led to significantly reduced weight loss and disease activity compared with vehicle controls. Treated groups were pyrexic but did not become subsequently hypothermic. PHDi treatment augmented epithelial barrier function and led to an approximately 50-fold reduction in serum endotoxin during colitis. AKB-4924 also decreased cytokines involved in pyrogenesis and hypothermia, significantly reducing serum levels of interleukin (IL)-1ß, IL-6, and tumor necrosis factor (TNF)-a while increasing IL-10. Treatment offered no protection against colitis in epithelial-specific HIF-1a-deficient mice, strongly implicating epithelial HIF-1a as the tissue target for AKB-4924-mediated protection. Taken together, these results indicate that inhibition of prolyl hydroxylase with AKB-4924 enhances innate immunity and identifies that the epithelium is a central site of inflammatory protection afforded by PHDi in murine colitis. © 2014 Society for Mucosal Immunology.

DOI10.1038/mi.2013.29
CitationsScopus - 8Web of Science - 8
Co-authorsSimon Keely
2014Chambers DC, Gellatly SL, Hugenholtz P, Hansbro PM, 'JTD special edition 'Hot Topics in COPD'-The microbiome in COPD', Journal of Thoracic Disease, 6 1525-1531 (2014) [C1]

The pathogenesis of chronic obstructive pulmonary disease (COPD) and its exacerbations, are intricately linked to colonisation and infection with bacteria and other microbes. Despite their undeniable importance, we have a poor understanding of the complex relationships between COPD phenotypes, physiology, cellular and molecular biology and the roles of colonising microbe or infecting pathogens. The management algorithms for the care of patients with COPD that include microbial influences, have almost exclusively been developed using microbial methods that were entirely dependent on the ability to grow bacteria on suitable media. The shortcomings of this approach are becoming clear now that it is possible to completely and accurately define the microbial ecology of ecosystems using genomic methods, which do not rely on the ability to cultivate the organisms present. Whilst our appreciation of the relationships between some bacterial ecosystems and the organ in which they reside in humans is now relatively advanced, this is not true for lung. This perspective serves to highlight the growing importance of including an accurate description of bacterial ecology in any attempt to decipher the pathobiology of COPD. While this field is in its infancy, there is significant potential to gain new insights which will translate into more rational and effective treatment algorithms for patients with COPD.

DOI10.3978/j.issn.2072-1439.2014.11.08
CitationsScopus - 3Web of Science - 3
2014Hansbro PM, Starkey MR, Mattes J, Horvat JC, 'Pulmonary immunity during respiratory infections in early life and the development of severe asthma', Annals of the American Thoracic Society, 11 S297-S302 (2014) [C1]

Asthma affects 10% of the population in Westernized countries, being most common in children. It is a heterogeneous condition characterized by chronic allergic airway inflammation, mucus hypersecretion, and airway hyperresponsiveness (AHR) to normally innocuous antigens. Combination therapies with inhaled corticosteroids and bronchodilators effectively manage mild to moderate asthma, but there are no cures, and patients with severe asthma do not respond to these treatments. The inception of asthma is linked to respiratory viral (respiratory syncytial virus, rhinovirus) and bacterial (Chlamydia, Mycoplasma) infections. The examination of mouse models of early-life infections and allergic airway disease (AAD) provides valuable insights into the mechanisms of disease inception that may lead to the development of more effective therapeutics. For example, early-life, but not adult, Chlamydia respiratory infections in mice permanently modify immunity and lung physiology. This increases the severity of AAD by promoting IL-13 expression, mucus hypersecretion, and AHR. We have identified novel roles for tumor necrosis factor-related apoptosisinducing ligand (TRAIL) and IL-13 in promoting infection-induced pathology in early life and subsequent chronic lung disease. Genetic deletion of TRAIL or IL-13 variously protected against neonatal infection-induced inflammation, mucus hypersecretion, altered lung structure, AHR, and impaired lung function. Therapeutic neutralization of these factors prevented infection-induced severe AAD. Other novel mechanisms and avenues for intervention are also being explored. Such studies indicate the immunological mechanisms that may underpin the association between early-life respiratory infections and the development of more severe asthma and may facilitate the development of tailored preventions and treatments.

DOI10.1513/AnnalsATS.201402-086AW
Co-authorsMalcolm Starkey, Joerg Mattes, Jay Horvat
2014Rehaume LM, Mondot S, Aguirre De Cárcer D, Velasco J, Benham H, Hasnain SZ, et al., 'ZAP-70 genotype disrupts the relationship between microbiota and host, leading to spondyloarthritis and ileitis in SKG mice', Arthritis and Rheumatology, 66 2780-2792 (2014) [C1]
DOI10.1002/art.38773
CitationsScopus - 3Web of Science - 4
2014McIlroy DJ, Jarnicki AG, Au GG, Lott N, Smith DW, Hansbro PM, Balogh ZJ, 'Mitochondrial DNA neutrophil extracellular traps are formed after trauma and subsequent surgery.', Journal of critical care, 29 1133.e1-1133.e5 (2014) [C1]
DOI10.1016/j.jcrc.2014.07.013
CitationsScopus - 1
Co-authorsGough Au, Douglas Smith, Zsolt Balogh
2014Sobinoff AP, Sutherland JM, Beckett EL, Stanger SJ, Johnson R, Jarnicki AG, et al., 'Damaging legacy: maternal cigarette smoking has long-term consequences for male offspring fertility.', Hum Reprod, 29 2719-2735 (2014) [C1]
DOI10.1093/humrep/deu235Author URL
CitationsScopus - 2Web of Science - 2
Co-authorsAdam Mccluskey, Eileen Mclaughlin
2013Starkey MR, Nguyen DH, Kim RY, Nair PM, Brown AC, Essifie A-T, et al., 'Programming of the Lung in Early Life by Bacterial Infections Predisposes to Chronic Respiratory Disease', CLINICAL OBSTETRICS AND GYNECOLOGY, 56 566-576 (2013) [C1]
DOI10.1097/GRF.0b013e3182993a0cAuthor URL
CitationsScopus - 2Web of Science - 1
Co-authorsJay Horvat, Malcolm Starkey
2013Hansbro P, Beckett E, Stevens R, Jarnicki A, Wark P, Foster P, 'A short-term model of COPD identifies a role for mast cell tryptase', EUROPEAN RESPIRATORY JOURNAL, 42 (2013)
Author URL
Co-authorsPeter Wark, Paul Foster
2013Thorburn AN, Brown AC, Nair PM, Chevalier N, Foster PS, Gibson PG, Hansbro PM, 'Pneumococcal Components Induce Regulatory T Cells That Attenuate the Development of Allergic Airways Disease by Deviating and Suppressing the Immune Response to Allergen', JOURNAL OF IMMUNOLOGY, 191 4112-4120 (2013) [C1]
DOI10.4049/jimmunol.1201232Author URL
CitationsScopus - 4Web of Science - 3
Co-authorsPeter Gibson, Paul Foster
2013Vijaykrishna D, Deng Y-M, Su YCF, Fourment M, Iannello P, Arzey GG, et al., 'The Recent Establishment of North American H10 Lineage Influenza Viruses in Australian Wild Waterfowl and the Evolution of Australian Avian Influenza Viruses', JOURNAL OF VIROLOGY, 87 10182-10189 (2013) [C1]
DOI10.1128/JVI.03437-12Author URL
CitationsScopus - 9Web of Science - 8
2013Fung KY, Mangan NE, Cumming H, Horvat JC, Mayall JR, Stifter SA, et al., 'Interferon-epsilon Protects the Female Reproductive Tract from Viral and Bacterial Infection', SCIENCE, 339 1088-1092 (2013) [C1]
DOI10.1126/science.1233321Author URL
CitationsScopus - 29Web of Science - 35
Co-authorsJay Horvat
2013Sobinoff AP, Beckett EL, Jarnicki AG, Sutherland JM, McCluskey A, Hansbro PM, McLaughlin EA, 'Scrambled and fried: Cigarette smoke exposure causes antral follicle destruction and oocyte dysfunction through oxidative stress', TOXICOLOGY AND APPLIED PHARMACOLOGY, 271 156-167 (2013) [C1]
DOI10.1016/j.taap.2013.05.009Author URL
CitationsScopus - 8Web of Science - 7
Co-authorsAdam Mccluskey, Eileen Mclaughlin
2013Beckett EL, Stevens RL, Jarnicki AG, Kim RY, Hanish I, Hansbro NG, et al., 'A new short-term mouse model of chronic obstructive pulmonary disease identifies a role for mast cell tryptase in pathogenesis', The Journal of Allergy and Clinical Immunology, 131 752-762 (2013) [C1]
CitationsScopus - 29Web of Science - 30
Co-authorsPaul Foster, Jay Horvat, Peter Wark, Nicole Hansbro, Simon Keely, Ming Yang
2013Foster PS, Plank MW, Collison AM, Tay HL, Kaiko GE, Li J, et al., 'The emerging role of microRNAs in regulating immune and inflammatory responses in the lung', Immunological Reviews, 253 198-215 (2013) [C1]
CitationsScopus - 8Web of Science - 11
Co-authorsJoerg Mattes, Ming Yang, Paul Foster
2013Balogh ZJ, McIlroy DJ, Smith DW, Hansbro PM, 'The origin and the role of mitochondrial DNA in postinjury inflammation', Journal of Critical Care, 28 1099-1100 (2013) [C3]
DOI10.1016/j.jcrc.2013.08.027
CitationsScopus - 2Web of Science - 2
Co-authorsZsolt Balogh, Douglas Smith
2013Griekspoor P, Colles FM, Mccarthy ND, Hansbro PM, Ashhurst-Smith C, Olsen B, et al., 'Marked host specificity and lack of phylogeographic population structure of Campylobacter jejuni in wild birds', MOLECULAR ECOLOGY, 22 1463-1472 (2013) [C1]
DOI10.1111/mec.12144Author URL
CitationsScopus - 16Web of Science - 13
2013Simpson JL, McDonald VM, Baines KJ, Oreo KM, Wang F, Hansbro PM, Gibson PG, 'Influence of Age, Past Smoking, and Disease Severity on TLR2, Neutrophilic Inflammation, and MMP-9 Levels in COPD', MEDIATORS OF INFLAMMATION, (2013) [C1]
DOI10.1155/2013/462934Author URL
CitationsScopus - 6Web of Science - 6
Co-authorsVanessa Mcdonald, Katherine Baines, Jodie Simpson, Peter Gibson
2013Hansbro PM, Knight DA, 'Are Lymphoid Follicles Important in the Pathogenesis of Chronic Obstructive Pulmonary Disease?', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 188 267-269 (2013) [C3]
DOI10.1164/rccm.201306-1073EDAuthor URL
CitationsScopus - 1Web of Science - 1
Co-authorsDarryl Knight
2013Hansbro PM, Scott GV, Essilfie A-T, Kim RY, Starkey MR, Nguyen D, et al., 'Th2 cytokine antagonists: Potential treatments for severe asthma', Expert Opinion on Investigational Drugs, 22 49-69 (2013) [C1]
CitationsScopus - 18Web of Science - 13
Co-authorsPaul Foster, Ming Yang, Malcolm Starkey, Jay Horvat
2013Starkey MR, Jarnicki AG, Essilfie A-T, Gellatly SL, Kim RY, Brown AC, et al., 'Murine models of infectious exacerbations of airway inflammation', CURRENT OPINION IN PHARMACOLOGY, 13 337-344 (2013) [C1]
DOI10.1016/j.coph.2013.03.005Author URL
CitationsScopus - 6Web of Science - 7
Co-authorsJay Horvat, Paul Foster, Malcolm Starkey
2013Li JJ, Tay HL, Plank M, Essilfie A-T, Hansbro PM, Foster PS, Yang M, 'Activation of Olfactory Receptors on Mouse Pulmonary Macrophages Promotes Monocyte Chemotactic Protein-1 Production', PLOS ONE, 8 (2013) [C1]
DOI10.1371/journal.pone.0080148Author URL
CitationsScopus - 2Web of Science - 1
Co-authorsPaul Foster, Ming Yang
2013Starkey MR, Essilfie A-T, Horvat JC, Kim RY, Nguyen DH, Beagley KW, et al., 'Constitutive production of IL-13 promotes early-life Chlamydia respiratory infection and allergic airway disease', Mucosal Immunology, 6 569-579 (2013) [C1]
CitationsScopus - 8Web of Science - 4
Co-authorsPaul Foster, Joerg Mattes, Malcolm Starkey, Jay Horvat
2012Wynne OL, Horvat JC, Smith R, Hansbro PM, Clifton VL, Hodgson DM, 'Effect of neonatal respiratory infection on adult BALB/c hippocampal glucocorticoid and mineralocorticoid receptors', Developmental Psychobiology, 54 568-575 (2012) [C1]
CitationsScopus - 1Web of Science - 1
Co-authorsDeborah Hodgson, Olivia Wynne, Jay Horvat, Vicki Clifton, Roger Smith
2012Prieto-Garcia A, Zheng D, Adachi R, Xing W, Xing W, Chung K, et al., 'Mast cell restricted mouse and human tryptase-heparin complexes hinder thrombin-induced coagulation of plasma and the generation of fibrin by proteolytically destroying fibrinogen', Journal of Biological Chemistry, 287 7834-7844 (2012) [C1]
CitationsScopus - 16Web of Science - 15
2012Thorburn AN, Foster PS, Gibson PG, Hansbro PM, 'Components of streptococcus pneumoniae suppress allergic airways disease and NKT cells by inducing regulatory T cells', The Journal of Immunology, 188 4611-4620 (2012) [C1]
CitationsScopus - 23Web of Science - 19
Co-authorsPeter Gibson, Paul Foster
2012Essilfie A-T, Simpson JL, Dunkley ML, Morgan LC, Oliver BG, Gibson PG, et al., 'Combined haemophilus influenzae respiratory infection and allergic airways disease drives chronic infection and features of neutrophilic asthma', Thorax, 67 588-599 (2012) [C1]
CitationsScopus - 32Web of Science - 29
Co-authorsJodie Simpson, Margaret Dunkley, Peter Gibson, Paul Foster
2012Suthers B, Hansbro PM, Thambar S, McEvoy MA, Peel R, Attia JR, 'Pneumococcal vaccination may induce anti-oxidized low-density lipoprotein antibodies that have potentially protective effects against cardiovascular disease', Vaccine, 30 3983-3985 (2012) [C1]
CitationsScopus - 4Web of Science - 5
Co-authorsJohn Attia, Roseanne Peel
2012Yang M, Kumar RK, Hansbro PM, Foster PS, 'Emerging roles of pulmonary macrophages in driving the development of severe asthma', Journal of Leukocyte Biology, 91 557-569 (2012) [C1]
CitationsScopus - 19Web of Science - 18
Co-authorsPaul Foster, Ming Yang
2012Hansbro PM, Jarnicki AG, 'Macrolides for macrophages in chronic obstructive pulmonary disease', Respirology, 17 739-740 (2012) [C3]
CitationsScopus - 4Web of Science - 4
2012Hsu A, See HV, Hansbro PM, Wark PA, 'Innate immunity to influenza in chronic airways diseases', Respirology, 17 1166-1175 (2012) [C1]
CitationsScopus - 12Web of Science - 10
Co-authorsAlan Hsu, Peter Wark
2012Beckett EL, Phipps S, Starkey MR, Horvat JC, Beagley KW, Foster PS, Hansbro PM, 'TLR2, but not TLR4, is required for effective host defence against chlamydia respiratory tract infection in early life', PLOS One, 7 e39460 (2012) [C1]
CitationsScopus - 17Web of Science - 16
Co-authorsPaul Foster, Malcolm Starkey, Jay Horvat
2012Hsu A, Parsons KS, Barr I, Lowther S, Middleton D, Hansbro PM, Wark PA, 'Critical role of constitutive type I interferon response in bronchial epithelial cell to influenza infection', PLoS One, 7 e32947 (2012) [C1]
DOI10.1371/journal.pone.0032947
CitationsScopus - 18Web of Science - 20
Co-authorsAlan Hsu, Peter Wark
2012Starkey MR, Kim RY, Beckett EL, Schilter HC, Shim D, Essilfie A-T, et al., 'Chlamydia muridarum lung infection in infants alters hematopoietic cells to promote allergic airway disease in mice', PLoS One, 7 e42588 (2012) [C1]
CitationsScopus - 7Web of Science - 6
Co-authorsJay Horvat, Joerg Mattes, Malcolm Starkey
2012Keely S, Talley NJ, Hansbro PM, 'Pulmonary-intestinal cross-talk in mucosal inflammatory disease', Mucosal Immunology, 5 7-18 (2012) [C1]
CitationsScopus - 26Web of Science - 27
Co-authorsSimon Keely, Nicholas Talley
2012Hansbro PM, Starkey MR, Kim RY, Stevens RL, Foster PS, Horvat JC, 'Programming of the lung by early-life infection', Journal of Developmental Origins of Health and Disease, 3 153-158 (2012) [C1]
CitationsScopus - 4Web of Science - 4
Co-authorsMalcolm Starkey, Paul Foster, Jay Horvat
2011Essilfie A-T, Simpson JL, Horvat JC, Preston JA, Dunkley ML, Foster PS, et al., 'Haemophilus influenzae infection drives IL-17-mediated neutrophilic allergic airways disease', PLoS Pathogens, 7 e1002244 (2011) [C1]
Co-authorsMargaret Dunkley, Jay Horvat, Paul Foster, Peter Gibson, Jodie Simpson
2011Asquith KL, Horvat JC, Kaiko GE, Carey AJ, Beagley KW, Hansbro PM, Foster PS, 'Interleukin-13 promotes susceptibility to chlamydial infection of the respiratory and genital tracts', PLoS Pathogens, 7 e1001339 (2011) [C1]
CitationsScopus - 24Web of Science - 20
Co-authorsJay Horvat, Paul Foster
2011Temple SEL, Hansbro PM, 'New insights into the immune response to pneumococci', Current Respiratory Medicine Reviews, 7 257-261 (2011) [C1]
DOI10.2174/157339811798281188
2011Wang W, Hansbro PM, Foster PS, Yang M, 'An alternate STAT6-independent pathway promotes eosinophil influx into blood during allergic airway inflammation', PLoS ONE, 6 e17766 (2011) [C1]
DOI10.1371/journal.pone.0017766
CitationsScopus - 7Web of Science - 6
Co-authorsMing Yang, Paul Foster
2011Hansbro PM, Kaiko GE, Foster PS, 'Cytokine/anti-cytokine therapy - Novel treatments for asthma?', British Journal of Pharmacology, 163 81-95 (2011) [C2]
DOI10.1111/j.1476-5381.2011.01219.x
CitationsScopus - 48Web of Science - 42
Co-authorsPaul Foster
2011Jennings PC, Merriman-Jones JA, Beckett EL, Hansbro PM, Jones KT, 'Increased zona pellucida thickness and meiotic spindle disruption in oocytes from cigarette smoking mice', Human Reproduction, 26 878-884 (2011) [C1]
DOI10.1093/humrep/deq393
CitationsScopus - 16Web of Science - 13
Co-authorsKeith Jones
2011Wynne OL, Horvat JC, Kim RY, Ong LK, Smith R, Hansbro PM, et al., 'Neonatal respiratory infection and adult re-infection: Effect on glucocorticoid and mineralocorticoid receptors in the hippocampus in BALB/c mice', Brain Behavior and Immunity, 25 1214-1222 (2011) [C1]
DOI10.1016/j.bbi.2011.03.014
CitationsScopus - 3Web of Science - 3
Co-authorsOlivia Wynne, Linkooi Ong, Roger Smith, Vicki Clifton, Deborah Hodgson, Jay Horvat
2011Preston JA, Thorburn AN, Starkey MR, Beckett EL, Horvat JC, Wade MA, et al., 'Streptococcus pneumoniae infection suppresses allergic airways disease by inducing regulatory T-cells', European Respiratory Journal, 37 53-64 (2011) [C1]
DOI10.1183/09031936.00049510
CitationsScopus - 31Web of Science - 29
Co-authorsMalcolm Starkey, Peter Gibson, Paul Foster, Jay Horvat
2011Hazlewood LC, Wood LG, Hansbro PM, Foster PS, 'Dietary lycopene supplementation suppresses Th2 responses and lung eosinophilia in a mouse model of allergic asthma', Journal of Nutritional Biochemistry, 22 95-100 (2011) [C1]
DOI10.1016/j.jnutbio.2009.12.003
CitationsScopus - 18Web of Science - 15
Co-authorsPaul Foster, Lisa Wood
2011Wynne OL, Horvat JC, Osei-Kumah A, Smith R, Hansbro PM, Clifton VL, Hodgson DM, 'Early life infection alters adult BALB/c hippocampal gene expression in a sex specific manner', Stress-the International Journal on the Biology of Stress, 14 247-261 (2011) [C1]
DOI10.3109/10253890.2010.532576
CitationsScopus - 9Web of Science - 9
Co-authorsDeborah Hodgson, Roger Smith, Olivia Wynne, Jay Horvat, Vicki Clifton
2011Hsu A, Barr I, Hansbro PM, Wark PA, 'Human influenza is more effective than Avian influenza at antiviral suppression in airway cells', American Journal of Respiratory Cell and Molecular Biology, 44 906-913 (2011) [C1]
DOI10.1165/rcmb.2010-0157OC
CitationsScopus - 12Web of Science - 9
Co-authorsAlan Hsu, Peter Wark
2011Hansbro PM, Hurt AC, 'Influenza surveillance in wild birds in Australia', Microbiology Australia, 32 48-51 (2011) [C1]
2010Lau JY, Oliver BG, Baraket M, Beckett EL, Hansbro NG, Moir LM, et al., 'Fibulin-1 Is increased in asthma - A novel mediator of airway remodeling?', Plos One, 5 1-13 (2010) [C1]
DOI10.1371/journal.pone.0013360
CitationsScopus - 15Web of Science - 12
Co-authorsNicole Hansbro, Paul Foster
2010Horvat JC, Starkey MR, Kim RY, Beagley KW, Preston JA, Gibson PG, et al., 'Chlamydial respiratory infection during allergen sensitization drives neutrophilic allergic airways disease', Journal of Immunology, 184 4159-4169 (2010) [C1]
DOI10.4049/jimmunol.0902287
CitationsScopus - 40Web of Science - 35
Co-authorsJay Horvat, Paul Foster, Peter Gibson, Malcolm Starkey
2010Li J, Wang W, Baines KJ, Bowden NA, Hansbro PM, Gibson PG, et al., 'IL-27/IFN-y induce MyD88-dependent steroid-resistant airway hyperresponsiveness by inhibiting glucocorticoid signaling in macrophages', Journal of Immunology, 185 4401-4409 (2010) [C1]
DOI10.4049/jimmunol.1001039
CitationsScopus - 35Web of Science - 32
Co-authorsKatherine Baines, Nikola Bowden, Ming Yang, Peter Gibson, Paul Foster
2010Thorburn AN, O'Sullivan BJ, Thomas R, Kumar RK, Foster PS, Gibson PG, Hansbro PM, 'Pneumococcal conjugate vaccine-induced regulatory T cells suppress the development of allergic airways disease', Thorax, 65 1053-1060 (2010) [C1]
DOI10.1136/thx.2009.131508
CitationsScopus - 29Web of Science - 28
Co-authorsPaul Foster, Peter Gibson
2010Horvat JC, Starkey MR, Kim RY, Phipps S, Gibson PG, Beagley KW, et al., 'Early-life chlamydial lung infection enhances allergic airways disease through age-dependent differences in immunopathology', Journal of Allergy and Clinical Immunology, 125 617-625 (2010) [C1]
DOI10.1016/j.jaci.2009.10.018
Co-authorsJay Horvat, Peter Gibson, Malcolm Starkey, Paul Foster
2010Starkey MR, Horvat JC, Kim RY, Hansbro PM, 'Reply', Journal of Allergy and Clinical Immunology, 125 1415 (2010) [C3]
DOI10.1016/j.jaci.2010.03.033
Co-authorsMalcolm Starkey, Jay Horvat
2010Wood LG, Hazlewood LC, Foster PS, Hansbro PM, 'Lyprinol reduces inflammation and improves lung function in a mouse model of allergic airways disease', Clinical and Experimental Allergy, 40 1785-1793 (2010) [C1]
DOI10.1111/j.1365-2222.2010.03503.x
CitationsScopus - 8Web of Science - 7
Co-authorsPaul Foster, Lisa Wood
2010Thorburn AN, Hansbro PM, 'Harnessing regulatory T cells to suppress asthma: From Potential to therapy', American Journal of Respiratory Cell and Molecular Biology, 43 511-519 (2010) [C1]
DOI10.1165/rcmb.2009-0342TR
CitationsScopus - 29Web of Science - 25
2010Wood LG, Simpson JL, Hansbro PM, Gibson PG, 'Potentially pathogenic bacteria cultured from the sputum of stable asthmatics are associated with increased 8-isoprostane and airway neutrophilia', Free Radical Research, 44 146-154 (2010) [C1]
DOI10.3109/10715760903362576
CitationsScopus - 23Web of Science - 18
Co-authorsLisa Wood, Peter Gibson, Jodie Simpson
2010Burgess JK, Boustany S, Moir LM, Weckmann M, Lau JY, Grafton K, et al., 'Reduction of tumstatin in asthmatic airways contributes to angiogenesis, inflammation, and hyperresponsiveness', American Journal of Respiratory and Critical Care Medicine, 181 106-115 (2010) [C1]
DOI10.1164/rccm.200904-0631oc
CitationsScopus - 21Web of Science - 18
Co-authorsPaul Foster, Nicole Hansbro
2010Hansbro PM, Warner S, Tracey JP, Arzey KE, Selleck P, O'Riley K, et al., 'Surveillance and analysis of avian influenza viruses, Australia', Emerging Infectious Diseases, 16 1896-1904 (2010) [C1]
DOI10.3201/eid1612.100776
CitationsScopus - 22Web of Science - 22
2010Wang W, Li J, Foster PS, Hansbro PM, Yang M, 'Potential therapeutic targets for steroid-resistant asthma', Current Drug Targets, 11 957-970 (2010) [C1]
DOI10.2174/138945010791591412
CitationsScopus - 25Web of Science - 24
Co-authorsPaul Foster, Ming Yang
2009Thorburn AN, Hansbro PM, Gibson PG, 'Pneumococcal vaccines for allergic airways diseases', Expert Opinion on Biological Therapy, 9 621-629 (2009) [C1]
DOI10.1517/14712590902916999
CitationsScopus - 14Web of Science - 12
Co-authorsPeter Gibson
2009Haynes L, Arzey E, Bell C, Buchanan N, Burgess G, Cronan V, et al., 'Australian surveillance for avian influenza viruses in wild birds between July 2005 and June 2007', Australian Veterinary Journal, 87 266-272 (2009) [C1]
DOI10.1111/j.1751-0813.2009.00446.x
CitationsScopus - 24Web of Science - 22
2009Beagley K, Huston WM, Hansbro PM, Timms P, 'Chlamydial infection of immune cells: Altered function and implications for disease', Critical Reviews in Immunology, 29 275-305 (2009) [C1]
DOI10.1615/CritRevImmunol.v29.i4.10
CitationsScopus - 35Web of Science - 33
2008Kaiko GE, Horvat JC, Beagley KW, Hansbro PM, 'Immunological decision-making: How does the immune system decide to mount a helper T-cell response?', Immunology, 123 326-338 (2008) [C1]
DOI10.1111/j.1365-2567.2007.02719.x
CitationsScopus - 125Web of Science - 116
Co-authorsJay Horvat
2008Kaiko GE, Phipps S, Hickey DK, Lam CE, Hansbro PM, Foster PS, Beagley KW, 'Chlamydia muridarum infection subverts dendritic cell function to promote Th2 immunity and airways hyperreactivity', Journal of Immunology, 180 2225-2232 (2008) [C1]
CitationsScopus - 30Web of Science - 29
Co-authorsPaul Foster
2008Asquith KL, Ramshaw HS, Hansbro PM, Beagley KW, Lopez AF, Foster PS, 'The IL-3/IL-5/GM-CSF common beta receptor plays a pivotal role in the regulation of Th2 immunity and allergic airway inflammation', Journal of Immunology, 180 1199-1206 (2008) [C1]
CitationsScopus - 58Web of Science - 57
Co-authorsPaul Foster
2008Hansbro NG, Horvat JC, Wark PA, Hansbro PM, 'Understanding the mechanisms of viral induced asthma: New therapeutic directions', Pharmacology & Therapeutics, 117 313-353 (2008) [C1]
DOI10.1016/j.pharmthera.2007.11.002
CitationsScopus - 57Web of Science - 50
Co-authorsNicole Hansbro, Jay Horvat, Peter Wark
2007Ashhurst-Smith CIJ, Hall ST, Walker PJ, Stuart JE, Hansbro PM, Blackwell CC, 'Isolation of Alloiococcus otitidis from Indigenous and non-Indigenous Australian children with chronic otitis media with effusion', FEMS Immunology and Medical Microbiology, 51 163-170 (2007) [C1]
DOI10.1111/j.1574-695X.2007.00297.x
CitationsScopus - 19Web of Science - 17
Co-authorsCaroline Blackwell, Sharron Hall, John Stuart
2007Horvat JC, Beagley KW, Wade MA, Preston JA, Hansbro NG, Hickey DK, et al., 'Neonatal chlamydial infection induces mixed T-cell responses that drive allergic airway disease', American Journal of Respiratory and Critical Care Medicine, 176 556-564 (2007) [C1]
DOI10.1164/rccm.200607-1005OC
CitationsScopus - 45Web of Science - 44
Co-authorsPeter Gibson, Jay Horvat, Paul Foster, Nicole Hansbro
2007Preston JA, Essilfie AT, Horvat JC, Wade MA, Beagley KW, Gibson PG, et al., 'Inhibition of allergic airways disease by immunomodulatory therapy with whole killed Streptococcus pneumoniae', Vaccine, 25 8154-8162 (2007) [C1]
DOI10.1016/j.vaccine.2007.09.034
CitationsScopus - 28Web of Science - 27
Co-authorsPaul Foster, Jay Horvat, Peter Gibson
2006Skelding KA, Hickey DK, Horvat JC, Bao SS, Roberts KG, Read JM, et al., 'Comparison of intranasal and transcutaneous immunization for induction of protective immunity against Chlamydia muridarum respiratory tract infection', Vaccine, 24 355-366 (2006) [C1]
DOI10.1016/j.vaccine.2005.07.104
CitationsScopus - 28Web of Science - 26
Co-authorsJay Horvat, Kathryn Skelding
2006Hurt AC, Hansbro PM, Selleck P, Olsen B, Minton C, Hampson AW, Barr IG, 'Isolation of avian influenza viruses from two different transhemispheric migratory shorebird species in Australia', Archives of Virology, 151 2301-2309 (2006) [C1]
DOI10.1007/s00705-006-0784-1
CitationsScopus - 30Web of Science - 27
2006Gasanov U, Koina CA, Beagley KW, Aitken RJ, Hansbro PM, 'Identification of the insulin-like growth factor II receptor as a novel receptor for binding and invasion by Listeria monocytogenes', Infection and Immunity, 74 566-577 (2006) [C1]
DOI10.1128/IAI.74.1.566-577.2006
CitationsScopus - 6Web of Science - 5
Co-authorsJohn Aitken
2006Sharkhuu T, Matthaei KI, Forbes E, Mahalingam S, Hogan SP, Hansbro PM, Foster PS, 'Mechanism of interleukin-25 (IL-17E)-induced pulmonary inflammation and airways hyper-reactivity', Clinical and Experimental Allergy, 36 1575-1583 (2006) [C1]
DOI10.1111/j.1365-2222.2006.02595.x
CitationsScopus - 62Web of Science - 54
Co-authorsPaul Foster
2006Yang M, Mattes J, Hansbro PM, Foster PS, 'Employment of microRNA profiles and RNA interference and antagomirs for the characterization and treatment of respiratory disease', Drug Discovery Today: Therapeutic Strategies, 3 325-332 (2006) [C1]
DOI10.1016/j.ddstr.2006.10.001
CitationsScopus - 4
Co-authorsPaul Foster, Ming Yang, Joerg Mattes
2005Stephenson J, Budd GM, Manning J, Hansbro PM, 'Major eruption-induced changes to the McDonald Islands, southern Indian Ocean', Antarctic Science, 17 259-266 (2005) [C1]
DOI10.1017/S095410200500266X
CitationsScopus - 2Web of Science - 2
2004Howland LJ, Hickey DK, Skelding KA, Bao S, Rendina AM, Hansbro PM, et al., 'Transcutaneous immunization with combined cholera toxin and CpG adjuvant protects against Chlamydia muridarum genital tract infection', Infection and Immunity, 72 1019-1028 (2004) [C1]
DOI10.1128/IAI.72.2.1019-1028.2004
CitationsScopus - 107Web of Science - 97
Co-authorsKathryn Skelding
2004Hansbro PM, Beagley KW, Horvat JC, Gibson PG, 'Role of atypical bacterial infection of the lung in predisposition/protection of asthma', Pharmacology and Therapeutics, 101 193-210 (2004) [C1]
DOI10.1016/j.pharmthera.2003.10.007
CitationsScopus - 63Web of Science - 54
Co-authorsJay Horvat, Peter Gibson
2004Preston JA, Beagley KW, Gibson PG, Hansbro PM, 'Genetic background affects susceptibility in nonfatal pneumococcal bronchopneumonia', Eur Respir J, 23 224-231 (2004) [C1]
DOI10.1183/09031936.03.00081403
CitationsScopus - 19Web of Science - 16
Co-authorsPeter Gibson
2002Badcock D, Hansbro PM, Hanniffy S, Clarke V, Schofield K, Robinson K, et al., 'Identification of Pneumoccal Vaccine Antigens Using a Gram-positive Secretion Reporter Screen in Lactococcus lactis', 3rd International Symposium on Pneumococci and Pneumococcal Diseases, n/a 103 (2002) [C3]
2002Preston JA, Beagley KW, Gibson PG, Hansbro PM, 'Development of a Pneumococcal Pneumonia Recovery Model in Mice', 3rd International Symposium on Pneumococci and Pneumococcal Diseases, n/a 91 (2002) [C3]
Co-authorsPeter Gibson
2001Preston JA, Beagley KW, Gibson PG, Hansbro PM, 'Effects of Infections by Streptococcus pneumoniae on Eosinophilic Immune Responses', Official Journal of the Australian Society for Microbiology, 22 A82 (2001) [C3]
Co-authorsPeter Gibson
2001Hansbro PM, Wells JM, Le Page RWF, Kyd J, 'Characterisation of a 37 kDa surface protein of Streptococcus pneumoniae that is protective against pneumococcal challenge', Final Program American Society for Microbiology, 101 General Meeting, 101 74 (2001) [C3]
2000Clark-Walker GD, Hansbro PM, Gibson F, Chen XJ, 'Mutant residues suppressing rho(0)-lethality in Kluyveromyces lactis occur at contact sites between subunits of F-1-ATPase', BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY, 1478 125-137 (2000)
DOI10.1016/S0167-4838(00)00003-0Author URL
CitationsWeb of Science - 22
1998Chen XJ, Hansbro PM, Clark-Walker GD, 'Suppression of rho(0) lethality by mitochondrial ATP synthase F-1 mutations in Kluyveromyces lactis occurs in the absence of F-0', MOLECULAR AND GENERAL GENETICS, 259 457-467 (1998)
Author URL
CitationsWeb of Science - 14
1998Hansbro PM, Chen XJ, Clark-Walker GD, 'Allele specific expression of the Mgi(-) phenotype on disruption of the F-1-ATPase delta-subunit gene in Kluyveromyces lactis', CURRENT GENETICS, 33 46-51 (1998)
DOI10.1007/s002940050307Author URL
CitationsWeb of Science - 6
1995O'Brien R, Taske N, Hansbro P, Matthaei K, Hogan S, Denborough M, Foster PS, 'Exclusion of defects in the skeletal muscle specific regions of the DHPR alpha 1 subunit as frequent causes of malignant hyperthermia', Journal of Medical Genetics, 32 913-914 (1995) [C1]
CitationsScopus - 5Web of Science - 7
Co-authorsPaul Foster
1994Hansbro P, Foster PS, Hogan S, Ozaki S, Denborough M, 'Purification and characterization of D-myo-Inositol (1,4,5)/(1,3,4,5)-polyphosphate 5-phosphatase from skeletal muscle', Archives of Biochemistry and Biophysics, 311 47-54 (1994) [C1]
CitationsScopus - 3Web of Science - 5
Co-authorsPaul Foster
1994Foster PS, Hansbro P, Liu C, Potter B, Denborough M, 'Kinetic analysis of novel inhibitors of inositol polyphosphate metabolism', Biochemical and Biophysical Research Communications, 200 8-15 (1994) [C1]
CitationsScopus - 2Web of Science - 2
Co-authorsPaul Foster
1994Foster PS, Hogan S, Hansbro P, O'Brien R, Potter B, Ozaki S, Denborough M, 'The metabolism of D-myo-inositol 1,4,5-trisphosphate and D-myo-inositol 1,3,4,5-tetrakisphosphate by porcine skeletal muscle', European Journal of Biochemistry, 222 955-964 (1994) [C1]
CitationsScopus - 12Web of Science - 12
Co-authorsPaul Foster
1994Hogan S, Foster PS, Hansbro P, Ozaki S, Denborough M, 'Detection and partial purification of inositol 1,4,5-trisphosphate 3-kinase from porcine skeletal muscle', Cellular Signalling, 6 233-243 (1994) [C1]
CitationsScopus - 5Web of Science - 4
Co-authorsPaul Foster
1992HANSBRO PM, BYARD SJ, BUSHBY RJ, TURNBULL PJH, BODEN N, SAUNDERS MR, et al., 'THE CONFORMATIONAL BEHAVIOR OF PHOSPHATIDYLINOSITOL IN MODEL MEMBRANES - H-2-NMR STUDIES', BIOCHIMICA ET BIOPHYSICA ACTA, 1112 187-196 (1992)
DOI10.1016/0005-2736(92)90391-XAuthor URL
CitationsScopus - 22Web of Science - 24
1990BUSHBY RJ, BYARD SJ, HANSBRO PM, REID DG, 'THE CONFORMATIONAL BEHAVIOR OF PHOSPHATIDYLINOSITOL', BIOCHIMICA ET BIOPHYSICA ACTA, 1044 231-236 (1990)
DOI10.1016/0005-2760(90)90307-JAuthor URL
CitationsWeb of Science - 14
1988SCHORAH CJ, BISHOP N, WALES JK, HANSBRO PM, HABIBZADEH N, 'BLOOD VITAMIN-C CONCENTRATIONS IN PATIENTS WITH DIABETES-MELLITUS', INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH, 58 312-318 (1988)
Author URL
CitationsScopus - 13Web of Science - 16
Show 126 more journal articles

Conference (115 outputs)

YearCitationAltmetricsLink
2015Kim R, Horvat J, Pinkerton J, Starkey M, Essilfie A, Mayall J, et al., 'INFECTION-INDUCED MICRORNA-21 DRIVES SEVERE, STEROID-INSENSITIVE EXPERIMENTAL ASTHMA BY AMPLIFYING PI3K-MEDIATED SUPPRESSION OF HDAC2', RESPIROLOGY (2015)
Author URL
2015Tay H, Kaiko G, Plank M, Li J, Essilfie A, Maltby S, et al., 'THE ROLE OF MIR-328 IN RESPIRATORY DISEASES', RESPIROLOGY (2015)
Author URL
Co-authorsSteven Maltby
2015Moheimani F, Roth H, Cross J, Reid A, Shaheen F, Warner S, et al., 'SUPPRESSION OF beta-CATENIN/CBP SIGNALING INHIBITS EPITHELIAL-MESENCHYMAL TRANSITION AND MIGRATION OF HUMAN AIRWAY EPITHELIUM', RESPIROLOGY (2015)
Author URL
Co-authorsFatemeh Moheimani
2014Mateer S, Maltby S, Marks E, Goggins B, Horvat J, Hansbro P, Keely S, 'Immune cell mis-homing drives secondary organ inflammation in inflammatory bowel disease; a focus on the respiratory system', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2014) [E3]
Author URL
Co-authorsSteven Maltby, Jay Horvat, Simon Keely
2014Hsu A, Parsons K, Fujita T, Hansbro P, Wark P, 'Critical role of PKR in antiviral stress granule and IFN-beta enhanceosome formation, and is impaired in chronic obstructive pulmonary disease', CYTOKINE, Melbourne, AUSTRALIA (2014) [E3]
DOI10.1016/j.cyto.2014.07.088Author URL
Co-authorsPeter Wark, Alan Hsu
2014Hsu A, Parsons K, Hansbro P, Wark P, 'Enhanced PI3K activity leads to decreased IFN-beta response to influenza infection in chronic obstructive pulmonary disease', CYTOKINE, Melbourne, AUSTRALIA (2014) [E3]
DOI10.1016/j.cyto.2014.07.089Author URL
Co-authorsPeter Wark, Alan Hsu
2014Starkey M, Hanish I, Dua K, Nair P, Haw T, Hsu A, et al., 'Interleukin-13 predisposes mice to more severe influenza infection by suppressing interferon responses and activating microRNA-21/PI3K', CYTOKINE, Melbourne, AUSTRALIA (2014) [E3]
DOI10.1016/j.cyto2014.07.182Author URL
Co-authorsPeter Wark, Jay Horvat, Paul Foster, Alan Hsu, Darryl Knight, Malcolm Starkey
2014Horvat J, Kim R, Mayall J, Pinkerton J, Starkey M, Essilfie A, et al., 'ANTIOXIDANT-BASED THERAPY FOR THE SUPPRESSION OF EARLY- LIFE INFECTION-INDUCED SEVERE ASTHMA', RESPIROLOGY (2014) [E3]
DOI10.1111/resp.12263_2Author URL
Co-authorsMalcolm Starkey, Lisa Wood, Jay Horvat
2014Jones B, Hansbro P, 'THE INVOLVEMENT OF HISTONE ACETYLATION ENZYMES IN A MOUSE MODEL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE', RESPIROLOGY (2014) [E3]
Author URL
2014Girkin J, Sokulsky L, Hatchwell L, Starkey M, Collison A, Hansbro P, Mattes J, 'IDENTIFICATION OF A NOVEL INTERLEUKIN-13 SIGNALLING PATHWAY', RESPIROLOGY (2014) [E3]
Author URL
Co-authorsMalcolm Starkey, Joerg Mattes
2014Hsu A, Parsons K, Hansbro P, Wark P, Wark P, 'IMPAIRED FORMATION OF ANTIVIRAL STRESS GRANULE AND INTERFERON-BETA ENHANCEOSOME LEADS TO REDUCED ANTIVIRAL RESPONSES TO INFLUENZA IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE', RESPIROLOGY (2014) [E3]
Author URL
Co-authorsPeter Wark, Alan Hsu
2013Rehaume L, Mondot S, de Carcer DA, Velasco J, Benham H, Hasnain S, et al., 'Host Genetic Background Disrupts The Relationship Between Microbiota and Gut Mucosal Tolerance Leading To Spondyloarthritis and Ileitis After a Dectin-1 Trigger.', ARTHRITIS AND RHEUMATISM, San Diego, CA (2013) [E3]
Author URL
2013Tay H, Kaiko G, Hansbro P, Foster P, 'The role of miRNA in regulating bacterial clearance', JOURNAL OF IMMUNOLOGY, Honolulu, HI (2013) [E3]
Author URL
Co-authorsPaul Foster
2013Hansbro P, Beckett E, Stevens R, Jarnicki A, Kim R, Hanish I, et al., 'A short-term model of COPD identifies a role for mast cell tryptase', JOURNAL OF IMMUNOLOGY, Honolulu, HI (2013) [E3]
Author URL
Co-authorsNicole Hansbro, Simon Keely, Paul Foster, Jay Horvat, Peter Wark, Ming Yang
2013Hansbro P, Horvat J, Essilfie A-T, Kim R, Mayall J, Starkey M, Foster P, 'Macrolides suppress key features of experimental steroid-sensitive and steroid-resistant asthma', JOURNAL OF IMMUNOLOGY, Honolulu, HI (2013) [E3]
Author URL
Co-authorsJay Horvat, Paul Foster, Malcolm Starkey
2013Kim RY, Horvat JC, Starkey MR, Essilfie A-T, Foster PS, Hansbro PM, 'MICRORNA INHIBITION IN NEONATAL CHLAMYDIA LUNG INFECTION PREVENTS INFECTION-INDUCED LUNG PATHOLOGY IN LATER LIFE', RESPIROLOGY (2013) [E3]
Author URL
Co-authorsMalcolm Starkey, Paul Foster, Jay Horvat
2013Horvat JC, Essilfie A-T, Kim RY, Mayall JR, Starkey MR, Beckett EL, et al., 'MACROLIDES SUPPRESS KEY FEATURES OF EXPERIMENTAL STEROID-SENSITIVE AND STEROID-RESISTANT ASTHMA', RESPIROLOGY (2013) [E3]
Author URL
CitationsScopus - 1
Co-authorsMalcolm Starkey, Jay Horvat, Peter Gibson, Paul Foster
2012Sobinoff AP, Beckett EL, Nixon B, Roman SD, Hansbro PM, McLaughlin EA, 'The impact of maternal cigarette smoke exposure on the male germline', Abstracts. The Annual Scientific Meeting of the Endocrine Society of Australia and the Society for Reproductive Biology 2012, Gold Coast, QLD (2012) [E3]
Co-authorsBrett Nixon, Shaun Roman, Eileen Mclaughlin
2012Stifter SA, Fung K, Horvat JC, Hansbro PM, De Weerd NA, Hertzog PJ, 'Expression, purification and biological characterisation of a novel type I interferon, IFN epsilon', Immunology, Glasgow, Scotland (2012) [E3]
Co-authorsJay Horvat
2012Kaiko GE, Tay HL, Plank MW, Hansbro PM, Foster PS, 'MicroRNA regulate bacterial phagocytosis in the lung', Immunology: Abstracts of the European Congress of Immunology, Glasgow, Scotland (2012) [E3]
Co-authorsPaul Foster
2012Starkey M, Kim R, Horvat J, Essilfie A-T, Beagley K, Mattes J, et al., 'Constitutive IL-13 promotes respiratory chlamydial infection and infection-induced chronic airway hyper-responsiveness', JOURNAL OF IMMUNOLOGY, Boston, MA (2012) [E3]
Author URL
Co-authorsJoerg Mattes, Paul Foster
2012Mateer S, Hansbro PM, Nolan GM, Chaney C, Minahan KL, Keely S, 'Development of pulmonary inflammation and altered lung function in a mouse model of colitis', Journal of Gastroenterology and Hepatology, Adelaide, S.A. (2012) [E3]
Co-authorsSimon Keely
2012Horvat JC, Essilfie A-T, Kim RY, Mayall JR, Starkey MR, Beckett EL, et al., 'Efficacy of antibiotic-based therapeutic strategies for the treatment of infection-induced, steroid-resistant allergic airways disease', Respirology, Canberra, ACT (2012) [E3]
Co-authorsMalcolm Starkey, Jay Horvat, Paul Foster
2012Hsu A, Parsons KS, Barr I, Hansbro PM, Wark PA, 'Deficient antiviral responses to influenza in primary bronchial epithelial cells of chronic obstructive pulmonary disease', Respirology, Canberra, ACT (2012) [E3]
Co-authorsPeter Wark, Alan Hsu
2012Plank MW, Kaiko GE, Luck H, Li J, Mattes J, Hansbro PM, Foster PS, 'The role of micrornas in CD4 T cell function', Respirology, Canberra, ACT (2012) [E3]
Co-authorsJoerg Mattes, Paul Foster
2012See HV, Simpson JL, Hansbro PM, Wark PA, 'Stable COPD patients have less rhinovirus-induced intracellular innate cytokines detected in PBMCS compared to healthy adults', Respirology, Canberra, ACT (2012) [E3]
Co-authorsJodie Simpson, Peter Wark
2012Starkey MR, Kim RY, Horvat JC, Essilfie A-T, Beagley KW, Mattes J, et al., 'Constitutive IL-13 promotes respiratory chlamydial infection-induced chronic airway hyperresponsiveness', Respirology, Canberra, ACT (2012) [E3]
Co-authorsJay Horvat, Paul Foster, Joerg Mattes, Malcolm Starkey
2012Tay HL, Kaiko GE, Plank MW, Mattes J, Hansbro PM, Foster PS, 'MiRNAs regulate bacterial infection in lungs', Respirology, Canberra, ACT (2012) [E3]
Co-authorsJoerg Mattes, Paul Foster
2012Keely S, Baird A, Kominsky D, McNamee EN, Hansbro PM, Shalwitz RA, Colgan SP, 'Immune modulation by prolyl hydroxylase inhibition contributes to the prevention of endotoxemia in a murine model of inflammatory bowel disease', FASEB Journal, San Diego, California (2012) [E3]
Co-authorsSimon Keely
2011O'Reilly M, Hansbro PM, Horvat JC, Sozo F, Harding R, 'Inhalation of hyperoxic gas in the neonatal period has long-term effects on the pulmonary airways', Journal of Developmental Origins of Health and Disease, Portland, Oregon (2011) [E3]
Co-authorsJay Horvat
2011Foster P, Li J, Wang W, Baines K, Bowden N, Hansbro P, et al., 'IL-27 underpins steroid resistant airway hyperresponsiveness via MyD88 dependent pathways', ALLERGY, Istanbul, TURKEY (2011) [E3]
Author URL
Co-authorsNikola Bowden
2011Wynnea O, Horvat JC, Kim RY, Ong LK, Smith R, Hansbro PM, et al., 'Sex differences in the effect of neonatal infection and adult re-infection on hippocampal corticosterone receptors and stress response outcomes', Brain, Behavior, and Immunity, Chicago, Illinois (2011) [E3]
Co-authorsLinkooi Ong, Jay Horvat, Roger Smith, Deborah Hodgson
2011O'Reilly M, Harding R, Hansbro PM, Sozo F, 'Exposure to hyperoxic gas in the neonatal period can cause long-term changes in lung function', Journal of Paediatrics and Child Health, Hobart, Tasmania (2011) [E3]
2011Foster PS, Tay HL, Kaiko GE, Plank MW, Mattes J, Hansbro PM, 'MiRNA and its roles in regulating bacterial infection in lungs', American Journal of Respiratory and Critical Care Medicine, Denver, CO (2011) [E3]
Co-authorsJoerg Mattes, Paul Foster
2011Hansbro PM, Horvat JC, Essilfie A-T, Kim RY, Simpson JL, Dunkley ML, et al., 'Infection-induced neutrophilic allergic airways disease is resistant to steroid treatment', American Journal of Respiratory and Critical Care Medicine, Denver, CO (2011) [E3]
Co-authorsPeter Gibson, Paul Foster, Jay Horvat, Margaret Dunkley, Jodie Simpson
2011Horvat JC, Essilfie A-T, Kim RY, Simpson JL, Dunkley ML, Beagley KW, et al., 'Investigation of infection-induced steroid resistant asthma', Respirology, Perth, WA (2011) [E3]
Co-authorsMargaret Dunkley, Peter Gibson, Paul Foster, Jay Horvat, Jodie Simpson
2011Oreo K, Baines KJ, Gibson PG, Hansbro PM, 'Pro-inflammatory cytokine production is impaired in response to TLR2 activation in healthy ageing and COPD', Respirology, Perth, WA (2011) [E3]
Co-authorsKatherine Baines, Peter Gibson
2011See HV, Simpson JL, Hansbro PM, Wark PA, 'COPD patients PBMCS have an impaired immune response to phinovirus-infected bronchial epithelium', Respirology, Perth, WA (2011) [E3]
Co-authorsJodie Simpson, Peter Wark
2010Hansbro PM, Essilfie A-T, Simpson JL, Dunkley ML, Horvat JC, Gibson PG, Foster PS, 'Haemophilus influenzae induces IL-17-mediated neutrophilic allergic airways disease', American Journal of Respiratory and Critical Care Medicine, New Orleans (2010) [E3]
CitationsScopus - 37Web of Science - 34
Co-authorsMargaret Dunkley, Jodie Simpson, Peter Gibson, Paul Foster, Jay Horvat
2010Thorburn AN, Foster PS, Gibson PG, Hansbro PM, 'Development of a streptococcus pneumoniae-based immunoregulatory therapy for asthma', American Journal of Respiratory and Critical Care Medicine, New Orleans (2010) [E3]
Co-authorsPeter Gibson, Paul Foster
2010Thorburn AN, Foster PS, Gibson PG, Hansbro PM, 'Streptococcus pneumoniae vaccine, prevenar, induces regulatory T cells and prevents allergic airways disease', American Journal of Respiratory and Critical Care Medicine, New Orleans (2010) [E3]
Co-authorsPeter Gibson, Paul Foster
2010O'Reilly M, Harding R, Beckett EL, Horvat JC, Hansbro PM, Sozo F, 'Exposure of the immature mouse lung to hyperoxic gas: do structural changes in the lung cause long-term changes in lung function?', 24th Fetal and Neonatal Physiology Workshop of Australia and New Zealand. Program and Abstracts, Wellington, NZ (2010) [E3]
Co-authorsJay Horvat
2010Fung K, Cumming H, Mangan N, Horvat JC, Hansbro PM, Hertzog P, 'Interferon epsilon regulates reproductive tract immunity to Chlamydia infection', Journal of Reproductive Immunology, Palm Cove, QLD (2010) [E3]
Co-authorsJay Horvat
2010Lam CE, Foo A, Essilfie A-T, Hansbro PM, Matthaei KI, Foster PS, Phipps S, 'Chemerin derived peptide reduces LPS and haemophilus influenza-induced emphysema in mice', Respirology, Brisbane, QLD (2010) [E3]
Co-authorsPaul Foster
2009Hansbro PM, Starkey MR, Horvat JC, Kim RY, Phipps S, Gibson PG, Foster PS, 'Early life chlamydial infection enhances allergic airways disease through age-dependent differences in immunopathology', Journal of Immunology, Seattle, WASH. (2009) [E3]
DOI10.1016/j.jaci.2009.10.018
Co-authorsMalcolm Starkey, Peter Gibson, Paul Foster, Jay Horvat
2009Hansbro PM, Thorburn AN, Foster PS, Gibson PG, 'Streptococcus pneumoniae vaccine, Prevenar, utilises Tregs to suppress asthma', Journal of Immunology, Seattle, WASH. (2009) [E3]
Co-authorsPeter Gibson, Paul Foster
2009Horvat JC, Starkey MR, Beagley KW, Gibson PG, Foster PS, Hansbro PM, 'Chlamydial respiratory infection predisposes to neutrophil dominated allergic airways disease (AAD)', Journal of Immunology, Seattle, WASH. (2009) [E3]
Co-authorsMalcolm Starkey, Peter Gibson, Paul Foster, Jay Horvat
2009Wark PA, Hsu A, Hansbro PM, 'Innate immune response of bronchial epithelial cells to infection with influenza', Journal of Immunology, Seattle, WASH. (2009) [E3]
Co-authorsPeter Wark, Alan Hsu
2009Wark PA, See HV, Simpson JL, Vanders RL, Hansbro PM, 'Peripheral blood monocytes (PBMCs) display innate antiviral response to rhinovirus (RV) infected bronchial epithelial cells', Journal of Immunology, Seattle, WASH. (2009) [E3]
Co-authorsJodie Simpson, Peter Wark
2009Fung KY, Cumming H, Mangan N, Stifter S, Horvat JC, Hansbro PM, Hertzog PJ, 'Characterisation of a novel, constitutive cytokine that regulates mucosal immunity in the reproductive tract', Cytokine, Lisbon, Portugal (2009) [E3]
DOI10.1016/j.cyto.2009.07.324
Co-authorsJay Horvat
2009Oldham RA, Simpson JL, Hansbro PM, Gibson PG, 'Increased bacterial load and colonisation in COPD', Respirology, Darwin, NT (2009) [E3]
DOI10.1111/j.1440-1843.2009.01503_1.x
Co-authorsJodie Simpson, Peter Gibson
2009Parsons KS, Gangireddy SR, Hansbro PM, Barr I, Wark PA, 'Response of primary bronchial epithelial cells to infection with human influenza virus', Respirology, Darwin, NT (2009) [E3]
DOI10.1111/j.1440-1843.2009.01502_7.x
Co-authorsPeter Wark
2009Thorburn AN, O'Sullivan B, Thomas R, Foster PS, Gibson PG, Hansbro PM, 'Prevenar suppresses allergic airways disease through the expansion of regulatory T cells', Respirology, Darwin, NT (2009) [E3]
DOI10.1111/j.1440-1843.2009.01503_1.x
Co-authorsPeter Gibson, Paul Foster
2009Oreo K, Baines KJ, Gibson PG, Hansbro PM, Simpson JL, 'Toll-like receptor agonists stimulate cytokine release from blood but not airway cells', Respirology, Darwin, NT (2009) [E3]
DOI10.1111/j.1440-1843.2009.01503_1.x
Co-authorsPeter Gibson, Katherine Baines, Jodie Simpson
2009Essilfie A-T, Simpson JL, Dunkley ML, Foster PS, Gibson PG, Hansbro PM, 'Haemophilus influenzae infection induces features of neutrophilic asthma', Respirology, Darwin, NT (2009) [E3]
DOI10.1111/j.1440-1843.2009.01503_1.x
Co-authorsPaul Foster, Peter Gibson, Jodie Simpson, Margaret Dunkley
2009Horvat JC, Starkey MR, Beagley KW, Preston JA, Gibson PG, Foster PS, Hansbro PM, 'Neutrophil influx during chlamydial lung infection determines the phenotype of allergic airways disease (AAD)', Respirology, Darwin, NT (2009) [E3]
DOI10.1111/j.1440-1843.2009.01503_1.x
Co-authorsJay Horvat, Paul Foster, Peter Gibson, Malcolm Starkey
2009Starkey MR, Horvat JC, Kim RY, Phipps S, Gibson PG, Beagley KW, et al., 'Early life chlamydial lung infection enhances allergic airways disease through age-dependent differences in immunopathology', Respirology, Darwin, NT (2009) [E3]
DOI10.1016/j.jaci.2009.10.018
CitationsScopus - 46Web of Science - 46
Co-authorsPeter Gibson, Malcolm Starkey, Paul Foster, Jay Horvat
2009Hsu A, Hansbro PM, Barr I, Wark PA, 'Innate immune response of bronchial epithelial cells to human and avian influenza virus', Respirology, Darwin, NT (2009) [E3]
Co-authorsPeter Wark, Alan Hsu
2009Weckmann M, Lau J, Grafton K, Oliver B, Hansbro NG, Foster PS, et al., 'Tumstatin: A non-collagenous domain of collagen IV: Effects on inflammation and angiogenesis', Respirology, Darwin, NT (2009) [E3]
Co-authorsNicole Hansbro, Paul Foster
2009Schilter HC, Shum B, Shim D, Maslowski K, Tsai L, Kim R, et al., 'Fatty acid binding proteins: A link between metabolism and airway inflammation?', Respirology, Darwin, NT (2009) [E3]
Co-authorsNicole Hansbro
2008Wynne OL, Horvat JC, Smith R, Hansbro PM, Clifton VL, Hodgson DM, 'Impact of neonatal infection on adult hippocampal glucocorticoid receptor, mineralocorticoid receptor and corticotrophin releasing hormone mRNA abundance', Proceedings of the Australian Neuroscience Society, Hobart, TAS (2008) [E3]
Co-authorsDeborah Hodgson, Roger Smith, Olivia Wynne, Jay Horvat, Vicki Clifton
2008Burgess JK, Boustany S, Oliver BG, Moir LM, Baraket M, Hansbro PM, et al., 'The absence of tumstatin in asthma may lead to angiogenesis and airway hyperresponsiveness', American Journal of Respiratory and Critical Care Medicine, Toronto, ONT (2008) [E3]
Co-authorsPaul Foster, Nicole Hansbro
2008Hansbro PM, Essilfie A-T, Foster PS, Gibson PG, 'Haemophilus influenzae (Hi) infection in asthma may drive the development of neutrophilic asthma (NA)', American Journal of Respiratory and Critical Care Medicine, Toronto, ONT (2008) [E3]
Co-authorsPeter Gibson, Paul Foster
2008Hansbro PM, Horvat JC, Beagley KW, Gibson PG, Foster PS, 'Neutrophil influx during chlamydial lung infection determines the phenotype of allergic airways disease', American Journal of Respiratory and Critical Care Medicine, Toronto, ONT (2008) [E3]
Co-authorsJay Horvat, Paul Foster, Peter Gibson
2008Hansbro PM, Thorburn AN, Foster PS, Gibson PG, 'Streptococcus Pneumoniae vaccine prevenar: A potential therapy for the suppression of asthma', American Journal of Respiratory and Critical Care Medicine, Toronto, ONT (2008) [E3]
Co-authorsPeter Gibson, Paul Foster
2008Simpson JL, Hansbro PM, McDonald VM, Gibson PG, 'Age and disease related changes in airway inflammation and inflammatory subtype in older people with COPD', American Journal of Respiratory and Critical Care Medicine, Toronto, ONT (2008) [E3]
Co-authorsVanessa Mcdonald, Jodie Simpson, Peter Gibson
2008Thorburn AN, Foster PS, Gibson PG, Hansbro PM, 'Streptococcus pneumoniae vaccine prevenar: A potential therapy for the suppression of asthma', Respirology, Melbourne, VIC (2008) [E3]
DOI10.1111/j.1440-1843.2008.01252.x
Co-authorsPaul Foster, Peter Gibson
2008Horvat JC, Beagley KW, Gibson PG, Foster PS, Hansbro PM, 'Neutrophil influx during chlamydial lung infection determines the phenotype of allergic airways disease', Respirology, Melbourne, VIC (2008) [E3]
DOI10.1111/j.1440-1843.2008.01252.x
Co-authorsPeter Gibson, Paul Foster, Jay Horvat
2008Essilfie A-T, Preston JA, Horvat JC, Dunkley ML, Foster PS, Gibson PG, et al., 'Haemophilus influenzae (Hi) infection in asthma may drive the development of neutrophilic asthma (NA)', Respirology, Melbourne, VIC (2008) [E3]
DOI10.1111/j.1440-1843.2008.01252.x
Co-authorsJay Horvat, Paul Foster, Peter Gibson, Jodie Simpson, Margaret Dunkley
2008Hansbro NG, Boustany S, Oliver B, Burgess J, Black J, Rosenberg H, et al., 'Early life pneumoviral infection induces the development of pulmonary angiogenesis', Respirology, Melbourne, VIC (2008) [E3]
DOI10.1111/j.1440-1843.2008.01252.x
Co-authorsPaul Foster, Nicole Hansbro
2008Simpson JL, Hansbro PM, McDonald VM, Gibson PG, 'Age and disease related changes in airway inflammation in older people with COPD', Respirology, Melbourne, VIC (2008) [E3]
DOI10.1111/j.1440-1843.2008.01252.x
Co-authorsJodie Simpson, Peter Gibson, Vanessa Mcdonald
2008Boustany S, Oliver BG, Moir LM, Black JL, Hansbro PM, Hansbro NG, et al., 'Tumstatin, an angiogenic inhibitor, modulates airway angiogenesis', Respirology, Melbourne, VIC (2008) [E3]
DOI10.1111/j.1440-1843.2008.01252_4.x
Co-authorsPaul Foster, Nicole Hansbro
2008Wynne OL, Horvat JC, Smith R, Hansbro PM, Clifton VL, Hodgson DM, 'Impact of neonatal infection on adult hippocampal glucocorticoid receptor and mineralocorticoid receptor abundance', 15th Annual Meeting of the Psychoneuroimmunology Research Society: Program, Madison, WISC (2008) [E3]
Co-authorsRoger Smith, Olivia Wynne, Jay Horvat, Deborah Hodgson, Vicki Clifton
2008Hansbro PM, Essilfie A-T, Simpson JL, Dunkley ML, Gibson PG, Foster PS, 'Haemophilus influenzae (HI) infection induces features of neutrophilic asthma', Australasian Society for Immunology 38th Annual Scientific Meeting: Delegate Book, Canberra, ACT (2008) [E3]
Co-authorsPaul Foster, Peter Gibson, Jodie Simpson, Margaret Dunkley
2008Hazelwood L, Wood LG, Hansbro PM, Foster PS, 'High fat diet reduces eosinophilic lung inflammation via nicotinic acetylcholine-dependent signaling', Australasian Society for Immunology 38th Annual Scientific Meeting: Delegate Book, Canberra, ACT (2008) [E3]
Co-authorsPaul Foster, Lisa Wood
2008Schilter H, Shim D, Maslowski K, Tsai L, Shum B, Kim RY, et al., 'A role for fatty acid binding proteins in respiratory inflammation', Australasian Society for Immunology 38th Annual Scientific Meeting: Delegate Book, Canberra, ACT (2008) [E3]
Co-authorsNicole Hansbro
2008Starkey MR, Horvat JC, Kim RY, Phipps S, Gibson PG, Beagley KW, et al., 'Early life chlamydial lung infection enhances allergic airways disease through age-dependent differences in immunopathology', Australasian Society for Immunology 38th Annual Scientific Meeting: Delegate Book, Canberra, ACT (2008) [E3]
Co-authorsJay Horvat, Paul Foster, Malcolm Starkey, Peter Gibson
2008Thorburn AN, O'Sullivan BJ, Thomas R, Foster PS, Gibson PG, Hansbro PM, 'Suppression of allergic airways disease by the Streptococcus pneumoniae vaccine prevenar through the induction of regulatory T cells', Australasian Society for Immunology 38th Annual Scientific Meeting: Delegate Book, Canberra, ACT (2008) [E3]
Co-authorsPeter Gibson, Paul Foster
2008Schilter HC, Shum BOV, Maslowski K, Sewell WA, Hotamisligil GS, Rolph MS, et al., 'Crucial role for fatty acid binding proteins in airway mediated immune responses', Final Programme and Abstracts: World Immune Regulation Meeting II, Davos, Switzerland (2008) [E3]
2008Hsu A, Hansbro PM, Wark PA, 'Innate immune response of bronchial epithelial cells to human and avian influenza virus', The 4th Congress of the Federation of Immunology Societies of Asia-Oceania: Conference Program, Taipei, Taiwan (2008) [E3]
Co-authorsPeter Wark, Alan Hsu
2008Asquith KL, Ramshaw H, Lopez A, Foster PS, 'The IL-3/IL-5/GM-CSF Common beta Receptor Plays a Pivotal Role in Regulating Th2 Immunity and Allergic Airway Inflammation', FASEB JOURNAL (2008) [E3]
Author URL
Co-authorsPaul Foster
2007Horvat JC, Preston JA, Gibson PG, Beagley KW, Foster PS, Hansbro PM, 'Development of allergic airways disease (AAD) is differentially affected by the timing of chlamydial infection relative to allergic sensitization', American Journal of Respiratory and Critical Care Medicine, San Francisco, Calif. (2007) [E3]
Co-authorsPaul Foster, Peter Gibson, Jay Horvat
2007Horvat JC, Garside CG, Wade MA, Preston JA, Hansbro NG, Gibson PG, et al., 'Development of allergic airways disease is differentially affected by chlamydial respiratory infection at different ages', American Journal of Respiratory and Critical Care Medicine, San Francisco, Calif. (2007) [E3]
Co-authorsJay Horvat, Peter Gibson, Nicole Hansbro, Paul Foster
2007Hansbro PM, 'Chlamydia pneumoniae and asthma', 2007 National Chlamydia Conference. Program, Brisbane, QLD (2007) [E3]
2007Wark PA, See HV, Oldham R, Timmins N, Gibson PG, Hansbro PM, 'Response by peripheral blood monocytes (PBMCs) to rhinovirus (RV) is greater in cells exposed to infected epithelium in coculture than exposed to RV alone', American Journal of Respiratory and Critical Care Medicine (American Thoracic Society 2007 International Conference Abstracts), San Francisco (2007) [E3]
Co-authorsPeter Wark, Peter Gibson
2007Wynne OL, Horvat JC, Smith R, Hansbro PM, Clifton VL, Hodgson DM, 'Impact of neonatal infection on adult hippocampal corticosterone receptor abundance and circulating corticosterone', Early Human Development, Perth (2007) [E3]
Co-authorsDeborah Hodgson, Olivia Wynne, Roger Smith, Jay Horvat, Vicki Clifton
2007Wynne OL, Horvat JC, Hansbro PM, Clifton VL, Hodgson DM, 'Impact of postnatal stress on neuroendocrine development and function in adulthood in the mouse', Fetal & Neonatal Workshop of Australia and New Zealand 21st Annual Meeting. Abstracts, Melbourne, VIC (2007) [E3]
Co-authorsOlivia Wynne, Deborah Hodgson, Jay Horvat, Vicki Clifton
2007Hansbro NG, Boustany S, Oliver BG, Burgess JK, Black JL, Hansbro PM, Foster PS, 'Viral-induced angiogenesis', Immuno 2007: 13th International Congress of Immunology. Abstracts and Posters, Rio de Janeiro, Brazil (2007) [E3]
Co-authorsPaul Foster, Nicole Hansbro
2007Essiflie A, Preston JA, Horvat JC, Dunkley ML, Foster PS, Gibson PG, et al., 'Elucidating the association between Haemophilus influenzae infection and neutrophilic allergic airways disease using mouse models', Immuno 2007: 13th International Congress of Immunology. Abstracts and Posters, Rio de Janeiro, Brazil (2007) [E3]
Co-authorsJay Horvat, Paul Foster, Peter Gibson, Jodie Simpson, Margaret Dunkley
2007Ferguson AL, Beagley KW, Hansbro PM, Foster PS, 'CD4+ T-cell programming by adult and neonatal bacterial infections inhibit the development of allergic airway inflammation in later life', Immuno 2007: 13th International Congress on Immunology. Abstracts and Posters, Rio de Janeiro, Brazil (2007) [E3]
Co-authorsPaul Foster
2007Horvat JC, Moller CG, Wade MA, Preston JA, Hansbro NG, Gibson PG, et al., 'Allergic airways disease (AAD) is differentially affected by chlamydial lung infection at different stages of life', Respirology (TSANZ Abstracts-Posters), Auckland (2007) [E3]
DOI10.1111/j.1440-1843.2007.001050.x
Co-authorsNicole Hansbro, Paul Foster, Jay Horvat, Peter Gibson
2007Horvat JC, Preston JA, Gibson PG, Beagley KW, Foster PS, Hansbro PM, 'Timing of chlamydial infection relative to allergen exposure differentially affects allergic airways disease', Respirology (TSANZ Abstracts-Posters), Auckland (2007) [E3]
Co-authorsPaul Foster, Jay Horvat, Peter Gibson
2007See H, Oldham R, Timmins N, Hansbro PM, Wark PA, Gibson PG, 'Rhinovirus (RV) induced inflammatory response in mononuclear cells is enhanced by coculture with airway epithelium', Respirology (TSANZ Abstracts-Posters), Auckland (2007) [E3]
DOI10.1111/j.1440-1843.2007.001050.x
Co-authorsPeter Gibson, Peter Wark
2007Simpson JL, Hansbro PM, Kenyon ME, Gibson PG, 'Remodelled asthma in the elderly: is asthma turning into COPD?', Respirology (TSANZ Abstracts-Posters), Auckland (2007) [E3]
Co-authorsJodie Simpson, Peter Gibson
2007Hansbro PM, Warner S, Hurt A, Curran J, 'Carriage of avian influenza viruses by shorebirds in Australia', Sixth Australasian Shorebird Conference 2007: Program and Abstracts, Newcastle, N.S.W. (2007) [E3]
2006Horvat JC, Preston JA, Gibson PG, Beagley KW, Foster PS, Hansbro PM, 'Exacerbation of Allergic Airways Disease (AAD) by Chlamydia is Differentially Affected by the Timing of Infection Relative to Allergen Exposure', Immunology and Cell Biology, Auckland, NZ (2006) [E3]
Co-authorsJay Horvat, Paul Foster, Peter Gibson
2006Preston JA, Horvat JC, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'Streptococcus pneumoniae (SPN) lung infection suppresses hallmark features of a mouse model of asthma', Immunology and Cell Biology, Auckland, NZ (2006) [E3]
Co-authorsPaul Foster, Peter Gibson, Jay Horvat
2006Horvat JC, Moller CG, Wade MA, Preston JA, Hansbro NG, Gibson PG, et al., 'The development of allergic airways disease (AAD) is differently affected by chlamydial lung infection at different stages of life', Immunology and Cell Biology, Auckland, NZ (2006) [E3]
Co-authorsPeter Gibson, Paul Foster, Jay Horvat, Nicole Hansbro
2006Horvat JC, Wade MA, Preston JA, Hansbro NG, Gibson PG, Beagley KW, et al., 'Early life chlamydial lung infection enhances allergic airways disease (AAD)', Respirology, Canberra (2006) [E3]
Co-authorsNicole Hansbro, Peter Gibson, Paul Foster, Jay Horvat
2006Preston JA, Horvat JC, Wade MA, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'Inhibition of allergic lung disease by respiratory streptococcus pneumoniae infection', Respirology, Canberra (2006) [E3]
Co-authorsPeter Gibson, Jay Horvat, Paul Foster
2006Horvat JC, Wade MA, Preston JA, Hansbro NG, Gibson PG, Beagley KW, et al., 'Neonatal chlamydial infection exacerbates allergic airways disease', Abstracts ATS 2006 International Conference, San Diego, California (2006) [E3]
Co-authorsPeter Gibson, Paul Foster, Jay Horvat, Nicole Hansbro
2006Preston JA, Horvat JC, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'Respiratory Streptococcus pneumoniae infection decreases key inflammatory responses in a mouse model of asthma', Abstracts ATS 2006 International Conference, San Diego, California (2006) [E3]
Co-authorsPeter Gibson, Paul Foster, Jay Horvat
2006Gadil E, Morris PS, Beissbarth J, Chang A, Gibson PG, Hare K, et al., 'Use of ototopical antibiotic treatment on chronic suppurative otitis media: A randomized placebo controlled trial and feasibility study', 5th International Symposim on Pneumoccoci and Pneumococcal Diseases, Alice Springs (2006) [E3]
Co-authorsPeter Gibson
2006Preston JA, Horvat JC, Wade MA, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'Inhibition of allergic lung disease by respiratory Streptococcus pneumoniae infection', 5th International Symposium on Pneumococci and Pneumococcal Diseases, Alice Springs (2006) [E3]
Co-authorsPaul Foster, Peter Gibson, Jay Horvat
2006Preston JA, Horvat JC, Wade MA, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'The influence of allergic airways disease on the immune response to respiratory Streptococcus pneumoniae infection', 5th International Symposium on Pneumococci and Pneumococcal Diseases, Alice Springs (2006) [E3]
Co-authorsPeter Gibson, Paul Foster, Jay Horvat
2005Preston JA, Horvat JC, Wade MA, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'Respiratory streptococcus pneumoniae infection decreases key inflammatory responses in a mouse model of asthma', TISSUE ANTIGENS, Melbourne, AUSTRALIA (2005)
Author URL
Co-authorsPaul Foster, Jay Horvat, Peter Gibson
2005Horvat JC, Wade MA, Preston JA, Newcombe N, Ferguson AL, Kaiko G, et al., 'Neonatal But Not Adult Chlamydial Infection Induces the Development of Allergic Airways Disease Through Novel Mechanisms Involving Inflammation of Mixed Phenotype', Tissue Antigens, Melbourne, Australia (2005) [E3]
CitationsWeb of Science - 1
Co-authorsPaul Foster, Jay Horvat, Peter Gibson
2005Horvat JC, Preston JA, Hansbro NG, Ferguson AL, Gibson PG, Beagley KW, et al., 'Neonatal chlamydial infection inhibits the development of allergic airway inflammation in adult mice', Inflammation Research, Melbourne, Australia (2005) [E3]
Co-authorsNicole Hansbro, Peter Gibson, Paul Foster, Jay Horvat
2005Wynne OL, Clifton VL, Murphy VE, Hodyl NA, Krivanek K, Smith D, et al., 'The Effects of Prenatal Endotoxin Exposure on Placental 11-HSD2 Activity and the Developing HPA Axis in the Fischer 344 Rat', Australian Neuroscience Society: Proceedings of the 25th Annual, Perth, Australia (2005) [E3]
Co-authorsOlivia Wynne, Vicki Clifton, Deborah Hodgson, Vanessa Murphy
2005Preston JA, Horvat JC, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'Timing of Streptococcus Pneumoniae (pnc) infection determines the magnitute of the effect on allergic airways inflammation (AAI) in a mouse model of asthma', Respirology, Perth Convention Exhibition Centre (2005) [E3]
Co-authorsPeter Gibson, Jay Horvat, Paul Foster
2005Preston JA, Horvat JC, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'Respiratory Streptococcus Pneumoniae Infection Decreases Eosinophilia and Mucus Cell Hyperplasia in a Mouse Model of Asthma', Respirology, Perth Convention Exhibition Centre (2005) [E3]
Co-authorsPeter Gibson, Paul Foster, Jay Horvat
2005Hurt AC, Hansbro PM, Selleck P, Olsen B, Barr IG, Hampson AW, 'Isolation of Avian Influenza Viruses from two different Transhemispheric migratory shorebird Species in Australia', Australian Virology Group, Phillip Island, Australia (2005) [E3]
2005Skelding KA, Hickey DK, Horvat JC, Hansbro PM, Bao S, Beagley KW, 'Combined transcutaneous and intranasal immunisation protects against genital tract Chlamydial infection', Proceedings of the Twelfth International Congress of Mucosal Immunology, Boston, Massachusetts, USA. (2005) [E3]
Co-authorsKathryn Skelding, Jay Horvat
2005Skelding KA, Hickey DK, Horvat JC, Hansbro PM, Bao S, Beagley KW, 'Comparison of intranasal and transcutaneous immunisation for the protection against Chlamydial pneumonia', Proceedings of the Twelfth International Congress of Mucosal Immunology, Boston, Massachusetts (2005) [E3]
Co-authorsJay Horvat, Kathryn Skelding
2003Berry L, Hickey DK, Skelding KA, Bao S, Hansbro PM, Beagley KW, 'Transcutaneous immunisation prevents Chlamydia muridarum genital tract infection', American Journal of Reproductive Immunology, - (2003) [E3]
Co-authorsKathryn Skelding
Show 112 more conferences

Patent (3 outputs)

YearCitationAltmetricsLink
2008Hansbro PM, Gibson PG, Vaccine compositions (2008) [I3]
Co-authorsPeter Gibson
2007Gibson PG, Hansbro PM, Treatment and prevention of allergic airways diseases (2007) [I3]
Co-authorsPeter Gibson
2001Hanniffy SB, Hansbro PM, Wells JM, Le Page RW, Lactococcal expression of exported protein-based discovery of Streptococcus pneumoniae genes encoding surface proteins. (2001) [I1]

Report (1 outputs)

YearCitationAltmetricsLink
2008Kirkland PD, Arzey KE, Tracey J, Hansbro PM, Rose K, 'Surveillance of wild birds in NSW for avian influenze viruses. Report to the Department of Agriculture, Fisheries and Forestry', NSW Department of Primary Industries, 15 (2008) [R2]
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Grants and Funding

Summary

Number of grants136
Total funding$17,109,264

Click on a grant title below to expand the full details for that specific grant.


20161 grants / $309,436

Investigation and therapeutic targeting of the immune mechanisms that predispose to and increase the severity of influenza in pregnancy$309,436

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamMs Rebecca Vanders, Professor Phil Hansbro
SchemeEarly Career Fellowships
RoleInvestigator
Funding Start2016
Funding Finish2016
GNoG1400642
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

20155 grants / $2,393,676

Modifying epigenetics as a novel treatment in COPD$1,076,254

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Phil Hansbro, Professor Darryl Knight, Conjoint Professor Peter Wark, Professor Ian Adcock
SchemeProject Grant
RoleLead
Funding Start2015
Funding Finish2015
GNoG1400006
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Development of new therapies for respiratory diseases and infection$828,300

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Phil Hansbro
SchemeResearch Fellowships
RoleLead
Funding Start2015
Funding Finish2015
GNoG1400019
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Elucidating the post-transcriptional regulation of mast cell proteases$443,900

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamProfessor Phil Hansbro, Professor Paul Hertzog, Professor Richard Stevens
SchemeDiscovery Projects
RoleLead
Funding Start2015
Funding Finish2015
GNoG1400517
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Characterising the airway and gut microbiome in severe asthma$25,222

Funding body: John Hunter Hospital Charitable Trust Fund

Funding bodyJohn Hunter Hospital Charitable Trust Fund
Project TeamAssociate Professor Jodie Simpson, Conjoint Associate Professor Nick Saltos, Professor Phil Hansbro
SchemeResearch Grant
RoleInvestigator
Funding Start2015
Funding Finish2015
GNoG1500009
Type Of FundingOther Public Sector - State
Category2OPS
UONY

Investigation of the progression of Alzheimers Disease: Identification of potential drivers of disease$20,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Jay Horvat, Associate Professor Liz Milward, Professor Phil Hansbro, Dr Daniel Johnstone
SchemeProject Grant
RoleInvestigator
Funding Start2015
Funding Finish2015
GNoG1500589
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

201410 grants / $1,679,026

Interferon epsilon for Chlamydia RTIs $729,817

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Phil Hansbro, Doctor Jay Horvat, Professor Paul Hertzog
SchemeProject Grant
RoleLead
Funding Start2014
Funding Finish2014
GNoG1300071
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

A novel approach to understanding Asthma: Focus on the epithelium $617,209

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Darryl Knight, Professor Phil Hansbro, Professor Stephen Stick, Dr Anthony Kicic
SchemeProject Grant
RoleInvestigator
Funding Start2014
Funding Finish2014
GNoG1300212
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Investigating the role of microbiomes in COPD$120,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamProfessor Phil Hansbro
SchemeProject Grant
RoleLead
Funding Start2014
Funding Finish2014
GNoG1400891
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

The Nanostring nCounter System$75,000

Funding body: Ramaciotti Foundations

Funding bodyRamaciotti Foundations
Project TeamProfessor Darryl Knight, Professor Phil Hansbro, Laureate Professor Paul Foster, Professor Rodney Scott, Conjoint Professor Peter Gibson, Professor Michael Nilsson
SchemeMajor Equipment Award
RoleInvestigator
Funding Start2014
Funding Finish2014
GNoG1300853
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

High Throughput Cell Genomics Centre$50,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Paul Hertzog, Professor James Whisstock, Professor Fabienne Mackay, Professor William Charman, Dr Jose Polo, Professor Elizabeth Hartland, Professor Martin Pera, Professor Phil Hansbro
SchemeEquipment Grant
RoleLead
Funding Start2014
Funding Finish2014
GNoG1300642
Type Of FundingInternal
CategoryINTE
UONY

The Nanostring nCounter System$40,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamProfessor Darryl Knight, Professor Phil Hansbro, Laureate Professor Paul Foster, Professor Rodney Scott, Conjoint Professor Peter Gibson, Professor Michael Nilsson
SchemeEquipment Grant
RoleInvestigator
Funding Start2014
Funding Finish2014
GNoG1301083
Type Of FundingOther Public Sector - State
Category2OPS
UONY

The Nanostring nCounter System$20,000

Funding body: John Hunter Hospital Charitable Trust Fund

Funding bodyJohn Hunter Hospital Charitable Trust Fund
Project TeamProfessor Darryl Knight, Professor Phil Hansbro, Laureate Professor Paul Foster, Professor Rodney Scott, Conjoint Professor Peter Gibson, Professor Michael Nilsson
SchemeResearch Grant
RoleInvestigator
Funding Start2014
Funding Finish2014
GNoG1301084
Type Of FundingOther Public Sector - State
Category2OPS
UONY

HMRI Award for Research Excellence$15,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamProfessor Phil Hansbro
SchemeSparke Helmore/NBN Television Corporate Triathlon Award for Research Excellence
RoleLead
Funding Start2014
Funding Finish2014
GNoG1301343
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

2014 International Visitor from Imperial College London, UK$10,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Phil Hansbro, Professor Ian Adcock
SchemeInternational Research Visiting Fellowship
RoleLead
Funding Start2014
Funding Finish2014
GNoG1400869
Type Of FundingInternal
CategoryINTE
UONY

American Thoracic Society, San Diego USA, 17-21 May 2014$2,000

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding bodyUniversity of Newcastle - Faculty of Health and Medicine
Project TeamProfessor Phil Hansbro
SchemeTravel Grant
RoleLead
Funding Start2014
Funding Finish2014
GNoG1400567
Type Of FundingInternal
CategoryINTE
UONY

20136 grants / $588,552

Enhancing innate immune responses to influenza in chronic obstructive pulmonary disease$504,552

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamConjoint Professor Peter Wark, Professor Phil Hansbro, Professor James Mahony
SchemeProject Grant
RoleInvestigator
Funding Start2013
Funding Finish2013
GNoG1200206
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Whitley DG250 Workstation – Anaerobic Incubator; MouseOxPlus® 230V – Pulse Oximeter for mice, rats, and other small laboratory animals$30,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Phil Hansbro
SchemeEquipment Grant
RoleLead
Funding Start2013
Funding Finish2013
GNoG1301307
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

Protecting Pregnant Women from Death during influenza epidemics$25,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamProfessor Roger Smith, Professor Phil Hansbro, Conjoint Professor Peter Wark
SchemeProject Grant
RoleInvestigator
Funding Start2013
Funding Finish2013
GNoG1301181
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

DP73 Digital colour and monochrome camera + cellSens software + Xcite120 fluorescence lamp illuminator$20,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamLaureate Professor Paul Foster, Doctor Alan Hsu, Professor Phil Hansbro, Professor Joerg Mattes, Doctor Katie Baines, Associate Professor Jodie Simpson, Professor Rakesh Kumar, Doctor Nicole Hansbro, Doctor Steven Maltby, Doctor Ming Yang, Doctor Gerard Kaiko, Doctor Jay Horvat, Doctor Simon Keely, Doctor Andrew Jarnicki, Doctor Michael Fricker
SchemeEquipment Grant
RoleInvestigator
Funding Start2013
Funding Finish2013
GNoG1201186
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

Australia-Harvard Fellowship$7,000

Funding body: Harvard Club of Australia Foundation

Funding bodyHarvard Club of Australia Foundation
Project TeamProfessor Phil Hansbro
SchemeAustralia-Harvard Fellowships
RoleLead
Funding Start2013
Funding Finish2013
GNoG1300903
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

International Congress of Immunology European Respiratory Society. 22-27 Aug 13 & 7-11 Sep 13$2,000

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding bodyUniversity of Newcastle - Faculty of Health and Medicine
Project TeamProfessor Phil Hansbro
SchemeTravel Grant
RoleLead
Funding Start2013
Funding Finish2013
GNoG1300797
Type Of FundingInternal
CategoryINTE
UONY

20128 grants / $801,879

Elucidating the role of mast cell tryptases in chronic obstructive pulmonary disease and Crohn's disease$609,879

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Phil Hansbro, Laureate Professor Nick Talley, Dr Brian Oliver
SchemeProject Grant
RoleLead
Funding Start2012
Funding Finish2012
GNoG1100239
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

SpectraMax M5e Multi-Mode Microplate Reader$50,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamLaureate Professor Paul Foster, Professor Phil Hansbro, Professor Joerg Mattes, Professor Rakesh Kumar, Doctor Nicole Hansbro, Doctor Ming Yang, Doctor Jay Horvat, Doctor Simon Keely, Doctor Andrew Jarnicki, Doctor Linda Howland, Doctor Kelly Asquith
SchemeEquipment Grant
RoleInvestigator
Funding Start2012
Funding Finish2012
GNoG1100975
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

Emphysema Research$50,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Phil Hansbro
SchemeSpecial Project Grant
RoleLead
Funding Start2012
Funding Finish2012
GNoG1201088
Type Of FundingInternal
CategoryINTE
UONY

Novel strategies to boost tristetraprolin function: a critical anti-inflammatory protein in asthma$30,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamAssociate Professor Alaina Ammit, Associate Professor Andrew Clark, Professor Phil Hansbro
SchemeProject Grant
RoleLead
Funding Start2012
Funding Finish2012
GNoG1200372
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

COPD-induced systemic inflammation activates mast cell specific tryptases which lead to cardiovascular disease $25,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamProfessor Phil Hansbro, Doctor Andrew Jarnicki
SchemeResearch Grant
RoleLead
Funding Start2012
Funding Finish2012
GNoG1200028
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Coordinated targeting of immune pathways to suppress infection-associated inflammatory diseases.$20,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Phil Hansbro, Professor Joerg Mattes
SchemeNear Miss Grant
RoleLead
Funding Start2012
Funding Finish2012
GNoG1200671
Type Of FundingInternal
CategoryINTE
UONY

Elucidating the mechanisms of steroid-resistant asthma$15,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Jay Horvat, Professor Phil Hansbro, Laureate Professor Paul Foster
SchemeResearch Grant
RoleInvestigator
Funding Start2012
Funding Finish2012
GNoG1200190
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

American Thoracic Society, San Francisco, 18 - 23 May 2012$2,000

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding bodyUniversity of Newcastle - Faculty of Health and Medicine
Project TeamProfessor Phil Hansbro
SchemeTravel Grant
RoleLead
Funding Start2012
Funding Finish2012
GNoG1200498
Type Of FundingInternal
CategoryINTE
UONY

201111 grants / $2,289,735

Identifying new therapeutic targets for preventing the induction and progression of COPD$626,732

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Phil Hansbro, Conjoint Professor Peter Wark
SchemeProject Grant
RoleLead
Funding Start2011
Funding Finish2011
GNoG1000252
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Understanding the mechanisms of respiratory viral infection- and COPD-induced predisposition to secondary bacterial pneumonia $573,390

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Phil Hansbro, Conjoint Professor Peter Wark
SchemeProject Grant
RoleLead
Funding Start2011
Funding Finish2011
GNoG1000248
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

A novel reproductive tract factor that protects against chlamydia$522,456

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Phil Hansbro, Professor Paul Hertzog
SchemeProject Grant
RoleLead
Funding Start2011
Funding Finish2011
GNoG1000251
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Development of microbial bioproducts for the suppression of inflammation$285,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamProfessor Phil Hansbro, Laureate Professor Paul Foster, Professor Rakesh Kumar
SchemeDiscovery Projects
RoleLead
Funding Start2011
Funding Finish2011
GNoG1000021
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Research microscope, confocal ready nikon eclipse 90i microscope$69,157

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Roger Smith, Conjoint Professor Tam Zakar, Professor Jon Hirst, Doctor Kaushik Maiti, Doctor Gemma Madsen, Professor Rodney Scott, Conjoint Professor Peter Wark, Laureate Professor Paul Foster, Professor Phil Hansbro, Conjoint Professor Ian Wright
SchemeEquipment Grant
RoleInvestigator
Funding Start2011
Funding Finish2011
GNoG1100024
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

DVCR Special Equipment Grant 2011$66,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Phil Hansbro
SchemeSpecial Project (Equipment) Grant
RoleLead
Funding Start2011
Funding Finish2011
GNoG1101126
Type Of FundingInternal
CategoryINTE
UONY

Maitland Cancer Appeal Committee Donation - Lung Cancer Mouse Model$50,000

Funding body: Maitland Cancer Appeal Committee

Funding bodyMaitland Cancer Appeal Committee
Project TeamProfessor Phil Hansbro, Laureate Professor Paul Foster, Doctor Gough Au
SchemeResearch Project
RoleLead
Funding Start2011
Funding Finish2011
GNoG1100246
Type Of FundingDonation - Aust Non Government
Category3AFD
UONY

SCIREQ FlexiVentFX system + FlexiVentFX extension$45,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Phil Hansbro, Laureate Professor Paul Foster, Professor Joerg Mattes, Doctor Simon Keely, Doctor Jay Horvat, Doctor Nicole Hansbro, Doctor Ming Yang, Doctor Catherine Ptaschinski, Doctor Kelly Asquith, Doctor Gough Au, Conjoint Professor Peter Wark, Laureate Professor John Aitken, Conjoint Professor Keith Jones, Professor Roger Smith, Professor Judith Black, Professor Rakesh Kumar, Professor Paul Hertzog
SchemeEquipment Grant
RoleLead
Funding Start2011
Funding Finish2011
GNoG1100037
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

Streptococcus pneumoniae-based immunoregulatory therapy for asthma$35,000

Funding body: Asthma Foundation of New South Wales

Funding bodyAsthma Foundation of New South Wales
Project TeamProfessor Phil Hansbro
SchemeInnovation Grants
RoleLead
Funding Start2011
Funding Finish2011
GNoG1000788
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

Antioxidant therapies for suppressing infection-induced asthma in children$15,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Jay Horvat, Associate Professor Lisa Wood, Professor Phil Hansbro
SchemeYouth Research Project Grant
RoleInvestigator
Funding Start2011
Funding Finish2011
GNoG1001002
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

American Thoracic Society, Colorado Convention Centre, 15 - 18 May 2010$2,000

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding bodyUniversity of Newcastle - Faculty of Health and Medicine
Project TeamProfessor Phil Hansbro
SchemeTravel Grant
RoleLead
Funding Start2011
Funding Finish2011
GNoG1100298
Type Of FundingInternal
CategoryINTE
UONY

20104 grants / $107,500

Refining Streptococcus pneumoniae-based immunoregulatory therapy to suppress asthma$44,500

Funding body: Asthma Foundation of New South Wales

Funding bodyAsthma Foundation of New South Wales
Project TeamProfessor Phil Hansbro, Professor Rakesh Kumar
SchemeResearch Grant
RoleLead
Funding Start2010
Funding Finish2010
GNoG0900076
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

Buxco FinePointe software and FinePointe RC system for mice $39,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamLaureate Professor Paul Foster, Professor Phil Hansbro, Professor Joerg Mattes, Doctor Nicole Hansbro, Doctor Simon Phipps, Doctor Ming Yang, Doctor Kelly Asquith, Doctor Catherine Ptaschinski, Professor Rakesh Kumar, Professor Judith Black
SchemeEquipment Grant
RoleInvestigator
Funding Start2010
Funding Finish2010
GNoG1000053
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

Targeting CXCR7 for fibrosis$22,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Phil Hansbro
SchemeDevelopment Grants
RoleLead
Funding Start2010
Funding Finish2010
GNoG1000682
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

American Thoracic Society, New Orleans, 14 - 19th May 2010$2,000

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding bodyUniversity of Newcastle - Faculty of Health and Medicine
Project TeamProfessor Phil Hansbro
SchemeTravel Grant
RoleLead
Funding Start2010
Funding Finish2010
GNoG1000126
Type Of FundingInternal
CategoryINTE
UONY

20098 grants / $1,266,230

Mechanisms and treatment of early life chlamydial infection and associated asthma$592,125

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Phil Hansbro, Professor Kenneth Beagley, Professor Joerg Mattes
SchemeProject Grant
RoleLead
Funding Start2009
Funding Finish2009
GNoG0188845
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

The Development of New and Effective Immunotherapies for Asthma$45,455

Funding body: Asthma Foundation of New South Wales

Funding bodyAsthma Foundation of New South Wales
Project TeamProfessor Phil Hansbro
SchemeAsthma Research Sustainability Grant
RoleLead
Funding Start2009
Funding Finish2009
GNoG0189728
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

Coulter counter$41,150

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamLaureate Professor Paul Foster, Professor Phil Hansbro, Professor Joerg Mattes, Doctor Simon Phipps, Doctor Ming Yang, Doctor Nicole Hansbro, Doctor Kelly Asquith
SchemeEquipment Grant
RoleInvestigator
Funding Start2009
Funding Finish2009
GNoG0189851
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

Immunisation against chlamydia-associated asthma$20,000

Funding body: Rebecca L Cooper Medical Research Foundation Ltd

Funding bodyRebecca L Cooper Medical Research Foundation Ltd
Project TeamDoctor Jay Horvat, Professor Phil Hansbro, Laureate Professor Paul Foster
SchemeResearch Grant
RoleInvestigator
Funding Start2009
Funding Finish2009
GNoG0189629
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

Prevention and treatment of asthma using streptococcus pneumoniae-based immunomododulatory therapy$20,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Phil Hansbro
SchemeNear Miss Grant
RoleLead
Funding Start2009
Funding Finish2009
GNoG0189815
Type Of FundingInternal
CategoryINTE
UONY

American Association of Immunologists and American Thoracic Society, Seattle USA, 8-12 May 2009$2,500

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding bodyUniversity of Newcastle - Faculty of Health and Medicine
Project TeamProfessor Phil Hansbro
SchemeTravel Grant
RoleLead
Funding Start2009
Funding Finish2009
GNoG0189963
Type Of FundingInternal
CategoryINTE
UONY

20085 grants / $502,150

The mechanisms of infection of bronchial epithelial cells by human & avian influenza viruses in chronic airways disease$379,650

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamConjoint Professor Peter Wark, Professor Phil Hansbro, Dr Ian Barr
SchemeProject Grant
RoleInvestigator
Funding Start2008
Funding Finish2008
GNoG0187593
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

The use of the components of the bacteria, streptococcus pneumoniae, as novel immunotherapies for asthma$50,000

Funding body: Asthma Foundation of New South Wales

Funding bodyAsthma Foundation of New South Wales
Project TeamProfessor Phil Hansbro, Professor Rakesh Kumar, Conjoint Professor Peter Wark
SchemeResearch Grant
RoleLead
Funding Start2008
Funding Finish2008
GNoG0188434
Type Of FundingDonation - Aust Non Government
Category3AFD
UONY

Individually ventilated cages (IVC) and associated ventilator, holding boxes and water bottles$35,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamLaureate Professor Paul Foster, Professor Phil Hansbro, Professor Joerg Mattes, Doctor Simon Phipps, Doctor Ming Yang, Doctor Nicole Hansbro, Doctor Kelly Asquith
SchemeEquipment Grant
RoleInvestigator
Funding Start2008
Funding Finish2008
GNoG0188541
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

Becton Dickinson high throughout sampler for the FACSCanto II cytometry system$35,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamConjoint Professor Peter Wark, Conjoint Professor Peter Gibson, Associate Professor Jodie Simpson, Associate Professor Lisa Wood, Doctor Vanessa Murphy, Professor Phil Hansbro
SchemeEquipment Grant
RoleInvestigator
Funding Start2008
Funding Finish2008
GNoG0188547
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

American Thoracic Society, Metro Toronto Convention Centre, 16/5/2008 - 21/5/2008$2,500

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Phil Hansbro
SchemeTravel Grant
RoleLead
Funding Start2008
Funding Finish2008
GNoG0188983
Type Of FundingInternal
CategoryINTE
UONY

200720 grants / $1,261,550

Characterisation and Treatment of Innate Immune Dysfunction in Older People with Obstructive Airway Disease$416,875

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamAssociate Professor Jodie Simpson, Conjoint Professor Peter Gibson, Professor Phil Hansbro
SchemeProject Grant
RoleInvestigator
Funding Start2007
Funding Finish2007
GNoG0186426
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Viruses, Infection/Immunology, vaccines and Asthma, Hunter medical Research Institute$230,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project Team
SchemeResearch Infrastructure
RoleInvestigator
Funding Start2007
Funding Finish2007
GNo
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Surveillance of wild birds for avian influenza viruses in NSW$180,024

Funding body: Department of Agriculture, Fisheries and Forestry Australia

Funding bodyDepartment of Agriculture, Fisheries and Forestry Australia
Project TeamDr Peter Kirkland, Professor Phil Hansbro
SchemeNew Industries Development Programme
RoleLead
Funding Start2007
Funding Finish2007
GNoG0186812
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

Investigation of chlamydial infection and asthma$68,000

Funding body: Faculty of Health

Funding bodyFaculty of Health
Project Team
SchemePostdoctoral Award
RoleLead
Funding Start2007
Funding Finish2007
GNo
Type Of FundingInternal
CategoryINTE
UONY

In vitro response of bronchial epithelial cells and activation of lymphocytes to infection with rhinovirus$58,848

Funding body: John Hunter Hospital Charitable Trust Fund

Funding bodyJohn Hunter Hospital Charitable Trust Fund
Project TeamConjoint Professor Peter Wark, Professor Phil Hansbro, Associate Professor Jodie Simpson
SchemeResearch Grant
RoleInvestigator
Funding Start2007
Funding Finish2007
GNoG0188095
Type Of FundingDonation - Aust Non Government
Category3AFD
UONY

Prevention of heart disease by pneumococcal vaccination$50,000

Funding body: Pfizer Australia

Funding bodyPfizer Australia
Project TeamProfessor Phil Hansbro, Dr Sukumaran Thambar, Professor John Attia, Mr Mark McEvoy
SchemeCardiovascular Lipid Research Grants
RoleLead
Funding Start2007
Funding Finish2007
GNoG0186642
Type Of FundingAust Competitive - Non Commonwealth
Category1NS
UONY

Nitric Oxide Monitoring System (NIOX)$45,000

Funding body: NHMRC (National Health & Medical Research Council)

In vitro response of bronchial epithelial cells and activation of lymphocytes from COPD patients by infection with rhinovirus, respiratory syncytial virus and haemophilus influenza$25,000

Funding body: GlaxoSmithKline Australia

Funding bodyGlaxoSmithKline Australia
Project TeamConjoint Professor Peter Wark, Professor Phil Hansbro, Associate Professor Jodie Simpson
SchemeSupport Grant
RoleInvestigator
Funding Start2007
Funding Finish2007
GNoG0188309
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Prevention and treatment of asthma by bacterial vaccination$22,500

Funding body: CRC for Asthma and Airways

Funding bodyCRC for Asthma and Airways
Project Team
SchemeUnknown
RoleInvestigator
Funding Start2007
Funding Finish2007
GNo
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

Elucidation of the association between Haemophilus influenzae infection and neutrophilic asthma.$20,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamProfessor Phil Hansbro, Associate Professor Jodie Simpson, Laureate Professor Paul Foster, Conjoint Professor Margaret Dunkley
SchemeProject Grant
RoleLead
Funding Start2007
Funding Finish2007
GNoG0187206
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

The role of tumstatin in angiogenesis and asthma$20,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamLaureate Professor Paul Foster, Doctor Nicole Hansbro, Doctor Simon Phipps, Professor Phil Hansbro
SchemeProject Grant
RoleInvestigator
Funding Start2007
Funding Finish2007
GNoG0187238
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Hewlett Packard 7890 series gas chromatograph with accessories$20,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamAssociate Professor Lisa Wood, Conjoint Professor Peter Wark, Conjoint Professor Peter Gibson, Associate Professor Jodie Simpson, Doctor Vanessa Murphy, Laureate Professor Paul Foster, Professor Phil Hansbro, Conjoint Associate Professor Vicki Clifton, Professor Clare Collins, Conjoint Professor Wayne Smith, Professor John Attia
SchemeEquipment Grant
RoleInvestigator
Funding Start2007
Funding Finish2007
GNoG0188191
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

Class II biohazard containment hood and carbon dioxide cell culture incubator$20,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamConjoint Professor Peter Wark, Conjoint Professor Peter Gibson, Associate Professor Jodie Simpson, Doctor Vanessa Murphy, Associate Professor Lisa Wood, Laureate Professor Paul Foster, Professor Phil Hansbro
SchemeEquipment Grant
RoleInvestigator
Funding Start2007
Funding Finish2007
GNoG0188192
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

Prevention of asthma by antibiotic treatment/vaccination against chlamydia$20,000

Funding body: Rebecca L Cooper Medical Research Foundation Ltd

Funding bodyRebecca L Cooper Medical Research Foundation Ltd
Project Team
SchemeResearch Award
RoleLead
Funding Start2007
Funding Finish2007
GNo
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

The prevention and treatment of Asthma with a diet high in seafood content$15,525

Funding body: Seafood Services Australia

Funding bodySeafood Services Australia
Project TeamProfessor Phil Hansbro, Laureate Professor Paul Foster
SchemeSeafood Industry Development Fund
RoleLead
Funding Start2007
Funding Finish2007
GNoG0185404
Type Of FundingAust Competitive - Non Commonwealth
Category1NS
UONY

Miccroarrays to identify novel therapeutic targets for bird flu$14,500

Funding body: John Hunter Hospital Charitable Trust Fund

Funding bodyJohn Hunter Hospital Charitable Trust Fund
Project TeamConjoint Professor Peter Wark, Professor Phil Hansbro
SchemeResearch Grant
RoleInvestigator
Funding Start2007
Funding Finish2007
GNoG0187337
Type Of FundingOther Public Sector - State
Category2OPS
UONY

Microarrays to identify novel therapeutic targets for bird flu$14,500

Funding body: John Hunter Hospital Charitable Trust Fund

Funding bodyJohn Hunter Hospital Charitable Trust Fund
Project Team
SchemeResearch Award
RoleLead
Funding Start2007
Funding Finish2007
GNo
Type Of FundingOther Public Sector - Local
Category2OPL
UONY

BioSafety Cabinet$10,778

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamProfessor Phil Hansbro
SchemeEquipment Grant
RoleLead
Funding Start2007
Funding Finish2007
GNoG0188049
Type Of FundingOther Public Sector - State
Category2OPS
UONY

The association between Chlamydial infection and asthma$7,500

Funding body: CRC for Asthma and Airways

Funding bodyCRC for Asthma and Airways
Project Team
SchemeResearch Scholars Award
RoleInvestigator
Funding Start2007
Funding Finish2007
GNo
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

International Congress on Immunology, Riocentro, Rio de Janeiro, 20/8/2007 - 24/8/2007$2,500

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Phil Hansbro
SchemeTravel Grant
RoleLead
Funding Start2007
Funding Finish2007
GNoG0187944
Type Of FundingInternal
CategoryINTE
UONY

200615 grants / $1,955,769

PRC Priority Research Centre for Asthma & Respiratory Diseases$524,282

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamLaureate Professor Paul Foster, Conjoint Professor Peter Gibson, Conjoint Professor Kenneth Beagley, Emeritus Professor Michael Hensley, Professor Phil Hansbro, Professor Joerg Mattes, Professor Alistair Sim, Conjoint Professor Peter Wark
SchemePriority Research Centre
RoleInvestigator
Funding Start2006
Funding Finish2006
GNoG0186914
Type Of FundingInternal
CategoryINTE
UONY

Investigation of the association between chlamydial infection and asthma in different age groups$362,625

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Phil Hansbro, Conjoint Professor Kenneth Beagley, Conjoint Professor Peter Gibson
SchemeProject Grant
RoleLead
Funding Start2006
Funding Finish2006
GNoG0185145
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Surveillance and Analysis of Avian Influenza Viruses in Migratory Birds in Australia$249,625

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Phil Hansbro, Dr Ian Barr, Conjoint Professor Peter Wark, Dr Paul Selleck, Dr Simone Warner, Laureate Professor Paul Foster, Dr Aeron Hurt, Dr Irene Peroulis, Dr John Curran, Conjoint Professor Peter Gibson
SchemePotential Avian Influenza-Induced Pandemic
RoleLead
Funding Start2006
Funding Finish2006
GNoG0186000
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

The Newcastle Asthma Meeting (NAMe)$210,000

Funding body: Astra Zeneca

Funding bodyAstra Zeneca
Project Team
SchemeConference support
RoleLead
Funding Start2006
Funding Finish2007
GNo
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Characterisation of novel immune signals as targets for the treatment of asthma$160,000

Funding body: Commonwealth serum laboratories

Funding bodyCommonwealth serum laboratories
Project Team
SchemeUnknown
RoleInvestigator
Funding Start2006
Funding Finish2006
GNo
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Priority Research Centre for Asthma and Respiratory Disease$120,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project Team
SchemePRC
RoleInvestigator
Funding Start2006
Funding Finish2007
GNo
Type Of FundingInternal
CategoryINTE
UONY

Development of mouse models of angiogenesis$115,000

Funding body: CRC for Asthma and Airways

Funding bodyCRC for Asthma and Airways
Project Team
SchemeResearch Scholars Award
RoleLead
Funding Start2006
Funding Finish2007
GNo
Type Of FundingInternal
CategoryINTE
UONY

Prevention of heart disease by pneumococcal vaccination$55,000

Funding body: CVL - Pfiser

Funding bodyCVL - Pfiser
Project Team
SchemeUnknown
RoleLead
Funding Start2006
Funding Finish2007
GNo
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Surveillance for avian influenza viruses in wild birds in Australia$50,000

Funding body: Perpetual Limited

Funding bodyPerpetual Limited
Project TeamProfessor Phil Hansbro
SchemeCharitable Trusts and Foundations Project
RoleLead
Funding Start2006
Funding Finish2006
GNoG0186511
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Surveillance of microbial carriage by different feeding guilds of birds$30,000

Research council of SE Sweden &amp; Swedish council for forestry &amp; agriculture
Funding body: Research council of SE Sweden & Swedish council for forestry & agriculture

Funding bodyResearch council of SE Sweden & Swedish council for forestry & agriculture
Project Team
SchemeResearch council of SE Sweden & Swedish council for forestry & agriculture
RoleLead
Funding Start2006
Funding Finish2006
GNo
Type Of FundingInternational - Non Competitive
Category3IFB
UONY

Identification of early-life signals induced in response to infection that predispose to asthma in later life$20,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Phil Hansbro, Laureate Professor Paul Foster, Conjoint Professor Kenneth Beagley, Professor Alistair Sim
SchemePilot Grant
RoleLead
Funding Start2006
Funding Finish2006
GNoG0186699
Type Of FundingInternal
CategoryINTE
UONY

Characterisation of chronic bacterial colonisation and the innate immune response in patients with neutrophilic asthma.$20,000

Funding body: Asthma Foundation of New South Wales

Funding bodyAsthma Foundation of New South Wales
Project Team
SchemeResearch Scholars Award
RoleInvestigator
Funding Start2006
Funding Finish2006
GNo
Type Of FundingOther Public Sector - State
Category2OPS
UONY

Characterisation of chronic bacterial colonisation and innate immune response in patients with neutrophilic Asthma$18,837

Funding body: Asthma Foundation of New South Wales

Funding bodyAsthma Foundation of New South Wales
Project TeamMrs Melanie Forster, Professor Phil Hansbro
SchemePhD Scholarships
RoleInvestigator
Funding Start2006
Funding Finish2006
GNoG0185993
Type Of FundingDonation - Aust Non Government
Category3AFD
UONY

-80¿C freezer$18,000

Funding body: Faculty of Health

Funding bodyFaculty of Health
Project Team
SchemeRIBG
RoleLead
Funding Start2006
Funding Finish2006
GNo
Type Of FundingInternal
CategoryINTE
UONY

American Thoracijavascript:closeProject();c Society 19-24 th of may 2006$2,400

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Phil Hansbro
SchemeTravel Grant
RoleLead
Funding Start2006
Funding Finish2006
GNoG0186495
Type Of FundingInternal
CategoryINTE
UONY

200512 grants / $2,758,219

Drug targets from new animal models$2,030,948

Funding body: CRC for Asthma

Funding bodyCRC for Asthma
Project TeamLaureate Professor Paul Foster, Professor Phil Hansbro, Professor Joerg Mattes, Doctor Ming Yang, Dr Simon Phipps
SchemeResearch Grant
RoleInvestigator
Funding Start2005
Funding Finish2005
GNoG0185860
Type Of FundingCRC - Cooperative Research Centre
Category4CRC
UONY

Viruses, Infection/Immunology, vaccines and Asthma, Hunter medical Research Institute$321,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project Team
SchemeResearch Infrastructure
RoleInvestigator
Funding Start2005
Funding Finish2007
GNo
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

CD4 T cell programming by neonatal and early-life infection$250,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamLaureate Professor Paul Foster, Conjoint Professor Kenneth Beagley, Professor Phil Hansbro
SchemeDiscovery Projects
RoleInvestigator
Funding Start2005
Funding Finish2005
GNoG0184398
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Modulation of inflammatory responses in the asthmatic lung by Chlamydial infection$50,000

Funding body: Asthma Foundation of New South Wales

Funding bodyAsthma Foundation of New South Wales
Project TeamProfessor Phil Hansbro, Laureate Professor Paul Foster, Conjoint Professor Kenneth Beagley
SchemeResearch Grant
RoleLead
Funding Start2005
Funding Finish2005
GNoG0185208
Type Of FundingDonation - Aust Non Government
Category3AFD
UONY

Flexivent complete system solution for measurement of lung function$25,000

Funding body: Ramaciotti Foundations

Funding bodyRamaciotti Foundations
Project TeamProfessor Phil Hansbro
SchemeMajor Equipment Award
RoleLead
Funding Start2005
Funding Finish2005
GNoG0185625
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

2005 RIBG allocation$23,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Phil Hansbro
SchemeResearch Infrastructure Block Grant (RIBG)
RoleLead
Funding Start2005
Funding Finish2005
GNoG0185803
Type Of FundingInternal
CategoryINTE
UONY

CD4 T cell programming by neonatal and early life infection$18,837

Funding body: Asthma Foundation of New South Wales

Funding bodyAsthma Foundation of New South Wales
Project TeamProfessor Phil Hansbro
SchemePhD Scholarships
RoleLead
Funding Start2005
Funding Finish2005
GNoG0184978
Type Of FundingDonation - Aust Non Government
Category3AFD
UONY

Chlamydia infection of dendritic cells drives the development of pro-asthmatic Th2 cells$15,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project Team
SchemeUnknown
RoleInvestigator
Funding Start2005
Funding Finish2005
GNo
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Prevention of asthma by immunisation with pneumococcal cell walls$10,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Phil Hansbro, Laureate Professor Paul Foster, Conjoint Professor Kenneth Beagley, Conjoint Professor Peter Gibson
SchemeProject Grant
RoleLead
Funding Start2005
Funding Finish2005
GNoG0184712
Type Of FundingInternal
CategoryINTE
UONY

Efficacy of anti-microbial strategies$7,275

Funding body: Whiteley Corporation Pty Ltd

Funding bodyWhiteley Corporation Pty Ltd
Project TeamProfessor Phil Hansbro
SchemeStudent Support Project
RoleLead
Funding Start2005
Funding Finish2005
GNoG0186017
Type Of FundingNot Known
CategoryUNKN
UONY

The effect of maternal infection on predisposition towards asthma in adulthood$6,029

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Deborah Hodgson, Conjoint Associate Professor Vicki Clifton, Professor Phil Hansbro
SchemeProject Grant
RoleInvestigator
Funding Start2005
Funding Finish2005
GNoG0184735
Type Of FundingInternal
CategoryINTE
UONY

World Inflammation Conference, 20-24 August 2005$1,130

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Phil Hansbro
SchemeTravel Grant
RoleLead
Funding Start2005
Funding Finish2005
GNoG0185614
Type Of FundingInternal
CategoryINTE
UONY

20048 grants / $145,300

Modulation of Asthma by bacterial infection or vaccination in different age groups$60,000

Funding body: Rebecca L Cooper Medical Research Foundation Ltd

Funding bodyRebecca L Cooper Medical Research Foundation Ltd
Project TeamProfessor Phil Hansbro, Laureate Professor Paul Foster, Conjoint Professor Kenneth Beagley
SchemeResearch Grant
RoleLead
Funding Start2004
Funding Finish2004
GNoG0184154
Type Of FundingDonation - Aust Non Government
Category3AFD
UONY

ELISA reader/Fluorimeter/Luminometer$31,900

Funding body: Faculty of Health

Funding bodyFaculty of Health
Project Team
SchemeRIBG
RoleInvestigator
Funding Start2004
Funding Finish2004
GNo
Type Of FundingInternal
CategoryINTE
UONY

Modulation of immune responses in asthma by bacterial infections during early life.$15,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Phil Hansbro, Laureate Professor Paul Foster, Conjoint Professor Peter Gibson
SchemeProject Grant
RoleLead
Funding Start2004
Funding Finish2004
GNoG0183512
Type Of FundingInternal
CategoryINTE
UONY

ELISA reader/Fluorimeter/Luminometer$11,000

Funding Body: Faculty of Health Funding Scheme: RIBG

Funding bodyUnknown
Project Team
SchemeUnknown
RoleLead
Funding Start2004
Funding Finish2004
GNo
Type Of FundingInternal
CategoryINTE
UONY

The effect of maternal inflammation on fetal development, placental function and neonatal immune competence: An animal model of asthma during pregnancy$10,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Deborah Hodgson, Conjoint Associate Professor Vicki Clifton, Professor Phil Hansbro
SchemeProject Grant
RoleInvestigator
Funding Start2004
Funding Finish2004
GNoG0183352
Type Of FundingInternal
CategoryINTE
UONY

Surveillance of microbial carriage by different feeding guilds of birds$10,000

Funding Body: Research council of SE Sweden & Swedish council for forestry & agriculture Funding Scheme: Research Award

Funding bodyUnknown
Project Team
SchemeUnknown
RoleLead
Funding Start2004
Funding Finish2005
GNo
Type Of FundingInternational - Non Competitive
Category3IFB
UONY

Modulation of asthma by chlamydial infection at different ages$5,000

Funding body: Asthma Foundation of New South Wales

Funding bodyAsthma Foundation of New South Wales
Project TeamDoctor Jay Horvat, Professor Phil Hansbro, Conjoint Professor Kenneth Beagley
SchemePhD Scholarships
RoleInvestigator
Funding Start2004
Funding Finish2004
GNoG0183717
Type Of FundingDonation - Aust Non Government
Category3AFD
UONY

International Symposium on the Pneumococcus & Pneumococcal Diseases, 9-13 May 2004$2,400

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Phil Hansbro
SchemeTravel Grant
RoleLead
Funding Start2004
Funding Finish2004
GNoG0183956
Type Of FundingInternal
CategoryINTE
UONY

20034 grants / $404,000

Viruses, Infection/Immunology, vaccines and Asthma, Hunter medical Research Institute$321,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project Team
SchemeResearch Infrastructure
RoleInvestigator
Funding Start2003
Funding Finish2005
GNo
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Modulation of immune responses in the asthmatic lung by bacterial infections.$50,000

Funding body: Asthma Foundation of New South Wales

Funding bodyAsthma Foundation of New South Wales
Project TeamProfessor Phil Hansbro, Conjoint Professor Peter Gibson, Conjoint Professor Kenneth Beagley, Dr Paul Foster
SchemeResearch Grant
RoleLead
Funding Start2003
Funding Finish2003
GNoG0183600
Type Of FundingDonation - Aust Non Government
Category3AFD
UONY

Treatment of asthma by vaccination with bacterial antigens.$17,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamProfessor Phil Hansbro, Conjoint Professor Peter Gibson, Conjoint Professor Kenneth Beagley
SchemeResearch Grant
RoleLead
Funding Start2003
Funding Finish2003
GNoG0182627
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Prevention and treatment of asthma by immunisation with bacterial vaccines.$16,000

Funding body: Rebecca L Cooper Medical Research Foundation Ltd

Funding bodyRebecca L Cooper Medical Research Foundation Ltd
Project TeamProfessor Phil Hansbro
SchemeResearch Grant
RoleLead
Funding Start2003
Funding Finish2003
GNoG0183365
Type Of FundingDonation - Aust Non Government
Category3AFD
UONY

20027 grants / $113,309

Refrigerated Microfuge & Ultracentrifuge Buckets$40,967

Funding body: Faculty of Medicine and Health Sciences

Funding bodyFaculty of Medicine and Health Sciences
Project Team
SchemeRIBG
RoleInvestigator
Funding Start2002
Funding Finish2002
GNo
Type Of FundingInternal
CategoryINTE
UONY

Modulation of inflammatory responses in the asthmatic lung by bacterial infection and vaccination.$24,842

Funding body: Asthma Foundation of New South Wales

Funding bodyAsthma Foundation of New South Wales
Project TeamMs Julie Preston, Conjoint Professor Peter Gibson, Professor Phil Hansbro
SchemePhD Scholarships
RoleInvestigator
Funding Start2002
Funding Finish2002
GNoG0181606
Type Of FundingDonation - Aust Non Government
Category3AFD
UONY

Development of new and improved pneumococcal vaccines.$16,000

Funding body: Rebecca L Cooper Medical Research Foundation Ltd

Funding bodyRebecca L Cooper Medical Research Foundation Ltd
Project TeamProfessor Phil Hansbro
SchemeResearch Grant
RoleLead
Funding Start2002
Funding Finish2002
GNoG0181997
Type Of FundingDonation - Aust Non Government
Category3AFD
UONY

Treatment of asthma by vaccination with bacterial antigens$12,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Phil Hansbro, Conjoint Professor Peter Gibson, Conjoint Professor Kenneth Beagley
SchemeProject Grant
RoleLead
Funding Start2002
Funding Finish2002
GNoG0181356
Type Of FundingInternal
CategoryINTE
UONY

PCR machine$10,000

Funding body: Faculty of Health

Funding bodyFaculty of Health
Project Team
SchemeEquipment grant
RoleInvestigator
Funding Start2002
Funding Finish2002
GNo
Type Of FundingInternal
CategoryINTE
UONY

Treatment of asthma by vaccination with bacterial antigens$7,000

Funding body: John Hunter Hospital Charitable Trust Fund

Funding bodyJohn Hunter Hospital Charitable Trust Fund
Project Team
SchemeResearch Award
RoleInvestigator
Funding Start2002
Funding Finish2002
GNo
Type Of FundingOther Public Sector - Local
Category2OPL
UONY

International Symposium on the Pneumococcus and Pneumococcal Diseases Anchorage, Alaska, 5 - 9 May, 2002$2,500

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Phil Hansbro
SchemeTravel Grant
RoleLead
Funding Start2002
Funding Finish2002
GNoG0181730
Type Of FundingInternal
CategoryINTE
UONY

20017 grants / $323,811

Development of new generation vaccines including DNA vaccines, for mucosal disease Eg respiratory and reproductive tract infection$210,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project Team
SchemeResearch Infrastructure
RoleInvestigator
Funding Start2001
Funding Finish2003
GNo
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Development of an Elisa-based detection system for Listeria spp. and Listeria monocytogenes utilizing recombinant antibodies$45,000

Funding body: Tecra International Pty Ltd

Funding bodyTecra International Pty Ltd
Project TeamProfessor Phil Hansbro, Associate Professor Darren Shafren
SchemeUniversity Grant Partner funding
RoleLead
Funding Start2001
Funding Finish2001
GNoG0181526
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Animal technician$38,045

Funding body: Faculty of Medicine and Health Sciences

Funding bodyFaculty of Medicine and Health Sciences
Project Team
SchemeRIBG
RoleInvestigator
Funding Start2001
Funding Finish2001
GNo
Type Of FundingInternal
CategoryINTE
UONY

Development of new and improved Pneumococcal vaccines.$12,000

Funding body: Ramaciotti Foundations

Funding bodyRamaciotti Foundations
Project TeamProfessor Phil Hansbro
SchemeResearch Grant
RoleLead
Funding Start2001
Funding Finish2001
GNoG0180651
Type Of FundingAust Competitive - Non Commonwealth
Category1NS
UONY

Development of an Elisa-based detection system for Listeria spp. and Listeria monocytogenes utilizing recombinant antibodies$10,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Phil Hansbro, Associate Professor Darren Shafren
SchemeCollaborative Research Grant
RoleLead
Funding Start2001
Funding Finish2001
GNoG0181525
Type Of FundingInternal
CategoryINTE
UONY

Effects of infections by Streptococcus pneumoniae on eosinophilic immune responses$7,000

Funding body: John Hunter Hospital

Funding bodyJohn Hunter Hospital
Project Team
SchemeRespiratory SP&T Research Funds
RoleLead
Funding Start2001
Funding Finish2001
GNo
Type Of FundingScheme excluded from IGS
CategoryEXCL
UONY

American Society for Microbiology, USA 20-24 May 2001$1,766

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Phil Hansbro
SchemeTravel Grant
RoleLead
Funding Start2001
Funding Finish2001
GNoG0180835
Type Of FundingInternal
CategoryINTE
UONY

20005 grants / $209,122

Gene Pulser II Electroporator$160,000

Funding body: Faculty of Medicine and Health Sciences

Funding bodyFaculty of Medicine and Health Sciences
Project Team
SchemeEquipment grant
RoleLead
Funding Start2000
Funding Finish2000
GNo
Type Of FundingInternal
CategoryINTE
UONY

Gel Doc 2000 UV Flourescent Gel Documentation System$21,522

Funding body: Faculty of Medicine and Health Sciences

Funding bodyFaculty of Medicine and Health Sciences
Project Team
SchemeEquipment grant
RoleLead
Funding Start2000
Funding Finish2000
GNo
Type Of FundingInternal
CategoryINTE
UONY

Development of new and improved pneumococcal vaccines$15,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project Team
SchemeEstablishment grant
RoleLead
Funding Start2000
Funding Finish2000
GNo
Type Of FundingScheme excluded from IGS
CategoryEXCL
UONY

Investigation of potential pneumococcal vaccine candidate antigens.$12,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Phil Hansbro
SchemeNew Staff Grant
RoleLead
Funding Start2000
Funding Finish2000
GNoG0179329
Type Of FundingInternal
CategoryINTE
UONY

Joint Annual Scientific Meeting & Exhibition of the Australian Society for Microbiology, Cairns QLD.$600

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Phil Hansbro
SchemeTravel Grant
RoleLead
Funding Start2000
Funding Finish2000
GNoG0180224
Type Of FundingInternal
CategoryINTE
UONY
Edit

Research Supervision

Current Supervision

CommencedResearch Title / Program / Supervisor Type
2015Fatty Acids and Bronchodilator Responses
Microbiology, Faculty of Health and Medicine
Principal Supervisor
2015Neuropathological Effects of Putative Modifiers of Alzheimer's Disease Risk and Progression: Investigation in Mouse Models
Health, Faculty of Health and Medicine
Co-Supervisor
2015Contribution of Cell Death to the Pathogenesis of Chronic Obstructive Pulmonary Disease (COPD)
Microbiology, Faculty of Health and Medicine
Principal Supervisor
2015Investigation of Novel Immune Molecules in the Pathogenesis of Female Chlamydia Genital Tract Infections
Microbiology, Faculty of Health and Medicine
Principal Supervisor
2015To assess the role of IFNe in modulating innate immune responses and protecting against Chlamydia infection in human tissues
Microbiology, Faculty of Health and Medicine
Principal Supervisor
2014Utilisation of Microbial Products as New Therapies for COPD/Emphysema
Microbiology, Faculty of Health and Medicine
Principal Supervisor
2014Effect of Iron loading on vision in a mouse model of haemochromatosis
Health, Faculty of Health and Medicine
Co-Supervisor
2014Chronic Obstructive Pulmonary Disease (COPD)
Microbiology, Faculty of Health and Medicine
Principal Supervisor
2014Investigating the Inter-Relationship between Iron Homeostasis and Infection in the Pathogenesis of Disease
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2013The Role of the PI3K Signalling Pathway in the Innate Antiviral Response of Airway Epithelial Cells
General Medicine, Faculty of Health and Medicine
Co-Supervisor
2013Role of TLR/IL-13/STAT6/PI3K Response in Early-life Respiratory Infection and Infection-Induced Chronic Lung Disease
Microbiology, Faculty of Health and Medicine
Principal Supervisor
2013Elucidating the Mechanisms of Infection-Induced, Steroid-Resistant Asthma
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2013Investigation of the pathogenesis and potential therapeutic interventions of influenza in Asthma and COPD
Microbiology, Faculty of Health and Medicine
Principal Supervisor
2012Investigating the Mechanisms of Tobacco Cigarette Smoke-Induced Lung Cancer
Microbiology, Faculty of Health and Medicine
Principal Supervisor
2012Roles of Bromodomain and extra terminal (BET) proteins in Suppression of Airway Inflammation
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2012Understanding the mechanisms of airway hyper-responsiveness in a mouse model of asthma
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2012Assessing the Epigenetic Involvement in the Development and Progression of Chronic Obstructive Pulmonary Disease (COPD)
Microbiology, Faculty of Health and Medicine
Principal Supervisor
2011The Role of Interferon Epsilon in Protection Against Chlamydial Reproductive Tract Infections
Microbiology, Faculty of Health and Medicine
Principal Supervisor
2011Mechanisms of Predisposition to Secondary Bacterial Pneumonia
Microbiology, Faculty of Health and Medicine
Principal Supervisor
2011The Role of Innate Cells in Infectious Exacerbation of COPD
Microbiology, Faculty of Health and Medicine
Principal Supervisor
2011Investigation of Pathogenesis of Chronic Obstructive Pulmonary Disease (COPD)
Microbiology, Faculty of Health and Medicine
Principal Supervisor
2011Immunoregulatory Therapies for Inflammatory Diseases
Microbiology, Faculty of Health and Medicine
Principal Supervisor
2011The Roles of Fibulin-1 in Airway Remodelling in Lung Diseases
Microbiology, Faculty of Health and Medicine
Principal Supervisor
2011Identifying the Mechanisms of Lung Inflammation Associated with Inflammatory Bowel Disease
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2010Indentification of New Therapeutics in COPD/ Emphysema
Microbiology, Faculty of Health and Medicine
Principal Supervisor
2009Mechanisms of Increased Susceptibility to Influenza Infection in Mouse Models of Chronic Lung Disease
Microbiology, Faculty of Health and Medicine
Principal Supervisor
2007Chlamydia and asthma II
Microbiology, University of Newcastle
Co-Supervisor
2007Chlamydia and asthma
Microbiology, University of Newcastle
Principal Supervisor
2007Rhinoviruses and asthma
Microbiology, University of Newcastle
Co-Supervisor
2006Investigation of fatty acid binding proteins and asthma
Microbiology, University of Sydney
Co-Supervisor

Past Supervision

YearResearch Title / Program / Supervisor Type
2015Investigation of the Mechanisms of Respiratory Infection- Induced Lung Disease
Microbiology, Faculty of Health and Medicine
Principal Supervisor
2015Characterising Innate Immune Responses and the Role of PD-1 in Patients with COPD
General Medicine, Faculty of Health and Medicine
Co-Supervisor
2014Immune Mechanisms that Underpin Early-Life Chlamydia Respiratory Infection-Induced Chronic Lung Disease
Microbiology, Faculty of Health and Medicine
Principal Supervisor
2014The Role of microRNAs in Allergic Airways Disease and T Cell Biology
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2014The Role of MicroRNA in Regulating Anti-Bacterial Responses in Innate Immune Cells
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2013The Role of Early Life Infection on the Programming of CD4+ T-cells
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2012Modulation of Responses in Allergic Airways Disease by Haemophilus Influenzae Infection
Microbiology, Faculty of Health and Medicine
Principal Supervisor
2012The Distribution, Abundance and Conservation of Avian Biodiversity in Yellow Sea Habitats in the Republic of Korea
Microbiology, Faculty of Health and Medicine
Principal Supervisor
2011The Innate Immune Mechanisms Underlying the Interplay Between Respiratory Infections and Asthma
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2011A Streptococcus pneumoniae-based Immunoregulatory Therapy for Asthma
Microbiology, Faculty of Health and Medicine
Principal Supervisor
2010Mechanism of Infection of Bronchial Epithelial Cells by Human and Avian Influenza Viruses
General Medicine, Faculty of Health and Medicine
Co-Supervisor
2009Nutritional Modulation of Lung Inflammation
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2008Modulation of Responses in the Asthmatic Lung by Chlamydial Infection
Microbiology, Faculty of Health and Medicine
Principal Supervisor
2007campylobacter carriage in birds
Microbiology, University of Newcastle
Principal Supervisor
2007Prevention and treatment of asthma using pneumococcal infection
Microbiology, University of Newcastle
Co-Supervisor
2007Modulation of Responses in the Asthmatic Lung by Streptococcus Pneumoniae
Microbiology, Faculty of Health and Medicine
Principal Supervisor
2006Investigation of Surface Components of Listeria spp. by Phage Display
Microbiology, Faculty of Health and Medicine
Principal Supervisor
2006Association of Haemophilus influenzae infection and asthma
Accounting, University of Newcastle
Principal Supervisor
2006Interaction of chlamydia with NOD proteins
Accounting, University of Newcastle
Co-Supervisor
2006Rhinoviruses and asthma
Microbiology, University of Newcastle
Co-Supervisor
2003Association of Chlamydia infection and asthma
Accounting, University of Newcastle
Principal Supervisor
2003Chlamydia in teh reproductive tract
Microbiology, University of Newcastle
Co-Supervisor
2001HIV infcetions
Microbiology, University of Newcastle
Co-Supervisor
2001Identification of novel surface proteins of Streptococcus pneumoniae
Microbiology, Unknown
Principal Supervisor
2001Prevention of asthma by pneumococcal infection
Microbiology, University of Newcastle
Principal Supervisor
Edit

News

Australian Research Council (ARC)

ARC Discovery Project funding success

November 19, 2014

Professor Phil Hansbro has been awarded more than $443,000 in ARC Discovery Project funding commencing in 2015 for his research project Elucidating the post-transcriptional regulation of mast cell proteases.

Modifying epigenetics as a novel treatment in COPD

NHMRC funding success

November 18, 2014

Professor Phil Hansbro and his team have been awarded over $1 million from the NHMRC to investigate modifying epigenetics as a novel treatment in COPD.

Professor Phil Hansbro

UON researcher awarded NHMRC Fellowship

September 2, 2014

UON researcher Professor Phil Hansbro has received a highly competitive NHMRC Principal Research Fellowship for a project titled Development of new therapies for respiratory diseases and infection.

‘transpoosion’ for a healthy gut

‘transpoosion’ for a healthy gut

August 25, 2014

Professor Phil Hansbro's research on the devastating lung disease emphysema, and the role of the microbiome in the gut in this disease, was featured on the ABC's Catalyst program.

Asthma discovery

Respiratory disease breakthrough

July 1, 2014

Sinister specks of a molecule known as ASC are escaping from cells then coursing through the body to exacerbate the biological inflammatory response in major airway diseases such as asthma and emphysema.

Phil Hansbro

HMRI 2013 Awards Night

November 7, 2013

Respiratory researcher Professor Phil Hansbro won the prestigious 2013 Award for Research Excellence tonight as more than $1.4 million in grant funding was awarded and acknowledged in the Hunter Medical Research Institute's 2013 Awards Night.

HMRI logo

Newcastle researchers help in fight against STDs

March 1, 2013

Newcastle researchers have contributed to the discovery of a protein in the female reproductive tract that protects against sexually transmitted diseases (STDs) such as chlamydia and herpes simplex virus (HSV).

Professor Phil Hansbro

Position

Professor, NHMRC Fellow and Brawn Fellow
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

Focus area

Immunology and Microbiology

Contact Details

Emailphilip.hansbro@newcastle.edu.au
Phone(02) 4042 0187
Mobile0427263084
Fax(02) 4042 0024

Office

RoomHMRI 2406
BuildingHMRI Building
LocationHMRI Building

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