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Career Summary

Qualifications

  • PhD, University of Melbourne
  • Bachelor of Science (Honours), University of Melbourne

Research

Research keywords

  • Parkinson's disease
  • catecholamines
  • dopamine
  • hierarchical phosphorylation
  • signal transduction
  • tyrosine hydroxylase

Research expertise

The focus of my work has been the enzyme tyrosine hydroxylase which controls the rate of synthesis of the catecholamines dopamine, noradrenaline and adrenaline. I have examined the control of tyrosine hydroxylase activity by phosphorylation and have shown that hierarchical phosphorylation(the phosphorylation one site affecting the rate of phosphorylation of another site on the same molecule) exists in tyrosine hydroxylase and plays an important role in the control of tyrosine hydroxylase activity. More recently my work has focused on how this regulation of tyrosine hydroxylase plays a role in Parkinson's disease. We have now found that there is a selective loss of one of the human TH isoforms in Parkinson's disease. Therefore the expression of particular TH isoforms may render the cells more susceptible to death in Parkinson's disease.

Fields of Research

CodeDescriptionPercentage
110199Medical Biochemistry And Metabolomics Not Elsewhere Classified40
060100Biochemistry And Cell Biology35
110900Neurosciences25

Invitations

13th International Symposium on Chromaffin Cell Biology
International Society for Neurochemistry (ISN), Chile (Conference Presentation - non published.)
2006

Administrative

Administrative expertise

I was the foundation program coordinator for the Bachelor of Biomedical Sciences Honours program. Since 2004 I have been Head of the Discipline of Medical Biochemistry and in 2006 took up the position as the Research Higher Degrees Coordinator for the School of Biomedical Sciences. I have been a member of both the School Research Executive and the School Teaching Committee. In 2009 I was appointed Deputy Head of School in charge of infrastructure.

Teaching

Teaching keywords

  • cellular biochemistry
  • molecular biology

Teaching expertise

The focus of my teaching has been biochemistry and molecular biology. I have taught into the general areas of cell organelle structure, enzymology, cell communication and signal transduction, DNA replication, DNA transcription and protein synthesis and molecular biological techniques.

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Highlighted Publications

For publications that are currently unpublished or in-press, details are shown in italics.

YearCitationAltmetricsLink
2006Lehmann IT, Bobrovskaya L, Gordon SL, Dunkley PR, Dickson PW, 'Differential regulation of the human tyrosine hydroxylase isoforms via hierarchical phosphorylation', Journal of Biological Chemistry, 281 17644-17651 (2006) [C1]
2001Bevilaqua L, Graham ME, Dunkley PR, Von Nagy-Felsobuki EI, Dickson PW, 'Phosphorylation of Ser19 Alters the Conformation of Tyrosine Hydroxylase to Increase the Rate of Phosphorylation of Ser40*', The Journal of Biological Chemistry, 276 No. 44 40411-40416 (2001) [C1]

Co-authors: Peter Dunkley

2004Dunkley PR, Bobrovskaya L, Graham ME, Von Nagy-Felsobuki EI, Dickson PW, 'Tyrosine hydroxylase phosphorylation: regulation and consequences', Journal of Neurochemistry, 91 1025-1043 (2004) [C1]

Publications

For publications that are currently unpublished or in-press, details are shown in italics.

Click on a category title below to expand the list of citations for that specific category.

Chapter (1 outputs)

YearCitationAltmetricsLink
2013Dickson PW, Briggs GD, 'Tyrosine hydroxylase. Regulation by feedback inhibition and phosphorylation.', 13-21 (2013) [B1]

Journal article (45 outputs)

YearCitationAltmetricsLink
2014James MH, Quinn RK, Ong LK, Levi EM, Charnley JL, Smith DW, et al., 'mTORC1 inhibition in the nucleus accumbens 'protects' against the expression of drug seeking and 'relapse' and is associated with reductions in GluA1 AMPAR and CAMKIIa levels.', Neuropsychopharmacology, 39 1694-1702 (2014) [C1]
2014Briggs GD, Bulley J, Dickson PW, ' Catalytic domain surface residues mediating catecholamine inhibition in tyrosine hydroxylase', Journal of Biochemistry, 155 183-193 (2014) [C1]
2014Stutz B, Da Conceição FSL, Santos LE, Cadilhe DV, Fleming RL, Acquarone M, et al., 'Murine dopaminergic Müller cells restore motor function in a model of Parkinson's disease', Journal of Neurochemistry, 128 829-840 (2014)
2014Abdul Majeed ABB, Pearsall E, Carpenter H, Brzozowski J, Dickson PW, Rostas JAP, Skelding KA, 'CaMKII Kinase Activity, Targeting and Control of Cellular Functions: Effect of Single and Double Phosphorylation of CaMKIIa', Calcium Signaling, 1 36-51 (2014)
2014Hoffman A, Carpenter H, Kahl R, Watt LF, Dickson PW, Rostas JAP, et al., 'Dephosphorylation of CaMKII at T253 controls the metaphase-anaphase transition', Cellular Signalling, 26 748-756 (2014)
2014Ong LK, Guan L, Damanhuri H, Goodchild AK, Bobrovskaya L, Dickson PW, Dunkley PR, 'Neurobiological consequences of acute footshock stress: Effects on tyrosine hydroxylase phosphorylation and activation in the rat brain and adrenal medulla', Journal of Neurochemistry, 128 547-560 (2014)
2013Sominsky L, Fuller EA, Bondarenko E, Ong LK, Averell L, Nalivaiko E, et al., 'Functional Programming of the Autonomic Nervous System by Early Life Immune Exposure: Implications for Anxiety', PLOS ONE, 8 (2013) [C1]
2013Briggs GD, Nagy GM, Dickson PW, 'Mechanism of action of salsolinol on tyrosine hydroxylase', Neurochemistry International, 63 726-731 (2013) [C1]
2013Briggs G, Bulley J, Dunkley PR, Dickson PW, 'Structural Basis for Regulation of Tyrosine Hydroxlyase by the Catecholamines 8-9 (2013) [E3]
2013Stutz B, Santos LE, Fleming RL, Gardino PF, de Melo Reis RA, de Mello FG, et al., 'Murine dopaminergic Müller cells restore motor function in a model of Parkinson's disease', Journal of Neurochemistry, (2013)
2012Ong LK, Sominsky L, Dickson PW, Hodgson DM, Dunkley PR, 'The sustained phase of Tyrosine hydroxylase activation in vivo', Neurochemical Research, 37 1938-1943 (2012) [C1]
2012Damanhuri HA, Burke PGR, Ong LK, Bobrovskaya L, Dickson PW, Dunkley PR, Goodchild AK, 'Tyrosine hydroxylase phosphorylation in catecholaminergic brain regions: A marker of activation following acute hypotension and glucoprivation', Plos One, 7 1-19 (2012) [C1]
2012Skelding KA, Spratt NJ, Fluechter L, Dickson PW, Rostas JA, 'alpha CaMKII is differentially regulated in brain regions that exhibit differing sensitivities to ischemia and excitotoxicity', Journal of Cerebral Blood Flow and Metabolism, 32 2181-2192 (2012) [C1]
2012Skelding KA, Dickson PW, Verrills NM, Rostas JA, 'Progression through mitosis can be controlled by dephosphorylation of CaMKII at T253', JOURNAL OF NEUROCHEMISTRY, 123 31-31 (2012) [E3]
2012Majeed ABA, Rostas JAP, Carpenter H, Dickson PW, Skelding KA, 'Multi-site phosphorylation of CaMKII regulates CaMKII function co-operatively', JOURNAL OF NEUROCHEMISTRY, 123 116-116 (2012) [E3]
2011Aumann TD, Egan K, Lim J, Boon WC, Bye CR, Chua HK, et al., 'Neuronal activity regulates expression of tyrosine hydroxylase in adult mouse substantia nigra pars compacta neurons', Journal of Neurochemistry, 116 646-658 (2011) [C1]
2011Ong LK, Bobrovskaya L, Walker FR, Day TA, Dickson PW, Dunkley PR, 'The effect of social defeat on tyrosine hydroxylase phosphorylation in the rat brain and adrenal gland', Neurochemical Research, 36 27-33 (2011) [C1]
2011Ong LK, Guan L, Stutz B, Dickson PW, Dunkley PR, Bobrovskaya L, 'The effects of footshock and immobilization stress on tyrosine hydroxylase phosphorylation in the rat locus coeruleus and adrenal gland', Neuroscience, 192 20-27 (2011) [C1]
2011Briggs GD, Gordon SL, Dickson PW, 'Mutational analysis of catecholamine binding in tyrosine hydroxylase', Biochemistry, 50 1545-1555 (2011) [C1]
2010Posser T, Dunkley PR, Dickson PW, Franco JL, 'Human neuroblastoma cells transfected with tyrosine hydroxylase gain increased resistance to methylmercury-induced cell death', Toxicology in Vitro, 24 1498-1503 (2010) [C1]
2010Bobrovskaya L, Damanhuri HA, Ong LK, Schneider JJ, Dickson PW, Dunkley PR, Goodchild AK, 'Signal transduction pathways and tyrosine hydroxylase regulation in the adrenal medulla following glucoprivation: An in vivo analysis', Neurochemistry International, 57 162-167 (2010) [C1]
2010Franco JL, Posser T, Gordon SL, Bobrovskaya L, Schneider JJ, Farina M, et al., 'Expression of tyrosine hydroxylase increases the resistance of human neuroblastoma cells to oxidative insults', Toxicological Sciences, 113 150-157 (2010) [C1]
2010Skelding KA, Suzuki T, Gordon SL, Xue J, Verrills NM, Dickson PW, Rostas JA, 'Regulation of CaMKII by phospho-Thr253 or phospho-Thr286 sensitive targeting alters cellular function', Cellular Signalling, 22 759-769 (2010) [C1]
2010Double KL, Halliday GM, Dunkley PR, Dickson PW, Gerlach M, Riederer P, 'Pigmentation in the human brain and risk of Parkinson's Disease', Annals of Neurology, 67 553-554 (2010) [C3]

Co-authors: Peter Dunkley

2009Franco JL, Posser T, Dunkley PR, Dickson PW, Mattos JJ, Martins R, et al., 'Methylmercury neurotoxicity is associated with inhibition of the antioxidant enzyme glutathione peroxidase', Free Radical Biology and Medicine, 47 449-457 (2009) [C1]
2009Gordon SL, Bobrovskaya L, Dunkley PR, Dickson PW, 'Differential regulation of human tyrosine hydroxylase isoforms 1 and 2 in situ: Isoform 2 is not phosphorylated at Ser35', Biochimica et Biophysica Acta - Molecular Cell Research, 1793 1860-1867 (2009) [C1]
2009Posser T, Franco JL, Bobrovskaya L, Leal RB, Dickson PW, Dunkley PR, 'Manganese induces sustained Ser40 phosphorylation and activation of tyrosine hydroxylase in PC12 cells', Journal of Neurochemistry, 110 848-856 (2009) [C1]
2009Gordon SL, Webb JK, Shehadeh J, Dunkley PR, Dickson PW, 'The low affinity dopamine binding site on tyrosine hydroxylase: The role of the N-Terminus and in situ regulation of enzyme activity', Neurochemical Research, 34 1830-1837 (2009) [C1]
2008Gordon SL, Quinsey NS, Dunkley PR, Dickson PW, 'Tyrosine hydroxylase activity is regulated by two distinct dopamine-binding sites', Journal of Neurochemistry, 106 1614-1623 (2008) [C1]
2007Gelain DP, Moreira JCF, Bevilaqua LRM, Dickson PW, Dunkley PR, 'Retinol activates tyrosine hydroxylase acutely by increasing the phosphorylation of serine40 and then serine31 in bovine adrenal chromaffin cells', Journal of Neurochemistry, 103 2369-2379 (2007) [C1]
2007Bobrovskaya L, Gilligan C, Bolster EK, Flaherty JJ, Dickson PW, Dunkley PR, 'Sustained phosphorylation of tyrosine hydroxylase at serine 40: a novel mechanism for maintenance of catecholamine synthesis', Journal of Neurochemistry, 100 479-489 (2007) [C1]
2007Bobrovskaya L, Gelain DP, Gilligan C, Dickson PW, Dunkley PR, 'PACAP stimulates the sustained phosphorylation of tyrosine hydroxylase at serine 40', Cellular Signalling, 19 1141-1149 (2007) [C1]
2006Migues PV, Lehmann IT, Fluechter L, Cammarota MP, Gurd JW, Sim AT, et al., 'Phosphorylation of CaMKII at Thr253 occurs in vivo and enhances binding to isolated postsynaptic densities', Journal of Neurochemistry, 98 289-299 (2006) [C1]
2006Lehmann IT, Bobrovskaya L, Gordon SL, Dunkley PR, Dickson PW, 'Differential regulation of the human tyrosine hydroxylase isoforms via hierarchical phosphorylation', Journal of Biological Chemistry, 281 17644-17651 (2006) [C1]
2005Graham ME, Dickson PW, Dunkley PR, Von Nagy-Felsobuki EI, 'Characterisation of tryptic peptides of phosphorylated tyrosine hydroxylase by high-pressure liquid chromatography electrospray ionisation mass spectrometry', Journal of Electron Spectroscopy and Related Phenomena, 142 271-276 (2005) [C1]
2004Dunkley PR, Bobrovskaya L, Graham ME, Von Nagy-Felsobuki EI, Dickson PW, 'Tyrosine hydroxylase phosphorylation: regulation and consequences', Journal of Neurochemistry, 91 1025-1043 (2004) [C1]
2003Bevilaqua L, Cammarota MP, Dickson PW, Sim AT, Dunkley PR, 'Role of protein phosphatase 2C from bovine adrenal chromaffin cells in the dephosphorylation of phospho-serine 40 tyrosine hydroxylase', Journal of Neurochemistry, 85 1368-1373 (2003) [C1]
2001Bevilaqua L, Graham ME, Dunkley PR, Von Nagy-Felsobuki EI, Dickson PW, 'Phosphorylation of Ser19 Alters the Conformation of Tyrosine Hydroxylase to Increase the Rate of Phosphorylation of Ser40*', The Journal of Biological Chemistry, 276 No. 44 40411-40416 (2001) [C1]

Co-authors: Peter Dunkley

2001Bevilaqua L, Graham ME, Von Nagy-Felsobuki EI, Dunkley PR, Dickson PW, 'Effect of phosphorylation on tyrosine hydroxylase shape', Journal of Neurochemistry, 78 Supt. 1 143 (2001) [C3]

Co-authors: Peter Dunkley

2001Graham ME, Bevilaqua L, Dunkley PR, Von Nagy-Felsobuki EI, Dickson PW, 'The Kinetics of CAMKII Phosphorylation of Dopamine Bound-Tyrosine Hydroxylase Determined by Electrospray Mass Spectrometry', ComBio 2001, 0 (2001) [C3]

Co-authors: Peter Dunkley

2000Graham ME, Dickson PW, Dunkley PR, Von Nagy-Felsobuki EI, 'Determination of Phosphorylation Levels of Tyrosine Hydroxylase by Electrospray Mass Spectrometry', Analytical Biochemistry, 280 1-7 (2000) [C1]

Co-authors: Ellak, Peter Dunkley

1999Dickson PW, Wong Z, Harrap S, Abramson M, Walters E, 'Mutational analysis of the high affinity immunoglobulin E receptor Beta subunit gene in asthma', Thorax (The Journal of the British Thoracic Society), 54 409-412 (1999) [C1]
1998Graham ME, Dickson PW, Dunkley PR, Von Nagy-Felsobuki EI, 'Characterisation of the phosphorylation of rat tyrosine hydroxylase using electrospray mass spectrometry', Rapid Communications in Mass Spectrometry, 12 746-748 (1998) [C1]

Co-authors: Peter Dunkley

1998Quinsey NS, Luong AQ, Dickson PW, 'Mutational analysis of substrate inhibition in tyrosine hydroxylase', Journal of Neurochemistry, 71 2132-2138 (1998) [C1]
1998Graham ME, Dickson P, Dunkley P, Von Nagy-Felsobuki EI, 'Characterization of the Phosphorylation of Rat Tyrosine Hydroxylase using Electrospray Mass Spectrometry', Rapid Communications in Mass Spectrometry, 12 746-748 (1998) [C1]

Co-authors: Ellak, Peter Dunkley

Show 42 more

Conference (49 outputs)

YearCitationAltmetricsLink
2014Ong LK, Briggs GD, Dunkley PR, Dickson PW, 'The role of inflammation and dopamine synthesis in Parkinson's disease', JOURNAL OF NEUROCHEMISTRY, Kaohsiung, TAIWAN (2014)
2013Guan L, Werno M, Gordon SL, Dunkley P, Dickson PW, 'The effect of tyrosine hydroxylase on alpha-synuclein aggregation', JOURNAL OF NEUROCHEMISTRY, Cancun, MEXICO (2013) [E3]
2013Skelding KA, Majeed ABA, Carpenter H, Dickson PW, Rostas JA, 'Can functional outcomes of CaMKII double phosphorylation be predicted from outcomes following single phosphorylation of CaMKII?', JOURNAL OF NEUROCHEMISTRY, Cancun, MEXICO (2013) [E3]
2012Guan L, Werno M, Gordon SL, Dunkley PR, Dickson PW, 'Effect of tyrosine hydroxylase on alphasynuclein aggregation', Abstracts. Australian Neuroscience Society 32nd Annual Meeting, Gold Coast, Queensland (2012) [E3]

Co-authors: Peter Dunkley

2012Rostas JA, Skelding KA, Fluechter L, Dickson PW, Spratt NJ, 'CaMKII is differentially regulated in striatum and cortex', Journal of Molecular Neuroscience: Abstracts The 21st Annual Meeting of the Israel Society for Neuroscience & The First Binational Australian-Israeli Meeting in Neuroscience, Eilat, Israel (2012) [E3]
2012Skelding KA, Dickson PW, Verrills NM, Rostas JA, 'Dephosphorylation of CAMKII at T253 controls progression through metaphase', Abstracts. Australian Neuroscience Society 32nd Annual Meeting, Gold Coast, Queensland (2012) [E3]
2012Skelding KA, Abdul Majeed ABB, Dickson PW, Spratt NJ, Rostas JA, 'CAMKII is regulated differently in brains regions with differing sensitivities to ischaemia/excitotoxicity', Abstracts. Australian Neuroscience Society 32nd Annual Meeting, Gold Coast, Queensland (2012) [E3]
2012Ong LK, Guan L, Bobrovskaya L, Dickson PW, Dunkley PR, 'Neurobiological consequences of acute footshock stress', Journal of Neurochemistry, Kobe, Japan (2012) [E3]
2012Abdul Majeed ABB, Skelding KA, Dickson PW, Rostas JA, 'Does phosphorylation of CaMKII at multiple sites regulate CaMKII targeting co-operatively or independently?', Abstracts. Australian Neuroscience Society 32nd Annual Meeting, Gold Coast, Queensland (2012) [E3]
2012James MH, Charnley JL, Levi EM, Dunkley PR, Smith DW, Dickson PW, Dayas CV, 'A role for the mTOR pathway in the development of addiction', Abstracts. Australian Neuroscience Society 32nd Annual Meeting, Gold Coast, Queensland (2012) [E3]
2012Rostas JA, Skelding KA, Fluechter L, Dickson PW, Spratt NJ, 'CaMKII is Differentially Regulated in Striatum and Cortex', JOURNAL OF NEUROCHEMISTRY (2012) [E3]
2012Briggs GD, Smith T, Hickey S, Dickson PW, 'A channel extending from the catalytic cleft of tyrosine hydroxylase is involved in high affinity catecholamine inhibition', Abstracts. Australian Neuroscience Society 32nd Annual Meeting, Gold Coast, Queensland (2012) [E3]
2010Skelding KA, Xue J, Suzuki T, Verrills NM, Dickson PW, Rostas JA, 'Mechanisms of phosphorylation-sensitive CaMKII targeting', Proceding of the Australian Neuroscience Society, Sydney, NSW (2010) [E3]
2010Ong LK, Guan L, Stutz B, Dickson PW, Dunkley PR, Bobrovskaya L, 'Tyrosine hydroxylase phosphorylation in response to footshock and restraint stress', Journal of Neurochemistry, Phuket, Thailand (2010) [E3]
2010Skelding KA, Verrills NM, Dickson PW, Rostas JA, 'Regulation of proliferation of neuroblastoma cells by CaMKII', Proceding of the Australian Neuroscience Society, Sydney, NSW (2010) [E3]
2009Bobrovskaya L, Damanhuri H, Ong LK, Dickson PW, Dunkley PR, Goodchild AK, 'The effect of glucoprivation on tyrosine hydroxylase phosphorylation in adrenals of Sprague-Dawley rats', Autonomic Neuroscience: Basic and Clinical, Sydney, NSW (2009) [E3]
2009Gordon SL, Dunkley PR, Dickson PW, 'The low affinity dopamine binding site regulates tyrosine hydroxylase activity in situ: Implications for the regulation of cytosolic catecholamine levels', ANS 2009 Abstracts: Posters, Canberra, ACT (2009) [E3]

Co-authors: Peter Dunkley

2009Gordon SL, Bobrovskaya L, Dunkley PR, Dickson PW, 'Differential regulation of the two major isoforms of human tyrosine hydroxylase in situ', Journal of Neurochemistry, Busan, Korea (2009) [E3]
2009Skelding KA, Liao X, Verrills NM, Fluechter L, Sim AT, Dickson PW, Rostas JA, 'Functional consequences of CaMKII phosphorylation at THR253 in neurons', ANS 2009 Abstracts: Posters, Canberra, ACT (2009) [E3]
2009Shehadeh J, Double K, Murphy K, Bobrovskaya L, Reyes S, Dunkley PR, et al., 'Differential distribution of tyrosine hydroxylase isoforms in the human brain', Parkinsonism & Related Disorders, Miami Beach, FL (2009) [E3]

Co-authors: Peter Dunkley

2009Ong LK, Bobrovskaya L, Walker FR, Day TA, Dickson PW, Dunkley PR, 'The effect of social conflict on tyrosine hydroxylase phosphorylation in catecholamine-producing cells from sprague-dawley rats', Journal of Neurochemistry, Busan, Korea (2009) [E3]
2009Briggs GD, Gordon SL, Dunkley PR, Dickson PW, 'Localisation of the low affinity catecholamine binding site in tyrosine hydroxylase', ANS 2009 Abstracts: Posters, Canberra, ACT (2009) [E3]

Co-authors: Peter Dunkley

2009Skelding KA, Liao X, Verrills NM, Fluechter L, Dickson PW, Rostas JA, 'CaMKII phosphorylation at T253 alters neuronal growth rates and morphology', Journal of Neurochemistry, Busan, Korea (2009) [E3]
2009Bobrovskaya L, Ong LK, Walker RA, Day TA, Dickson PW, Dunkley PR, 'The effect of social stress on tyrosine hydroxylase phosphorylation', ANS 2009 Abstracts: Posters, Canberra, ACT (2009) [E3]
2009Dickson PW, Shehadeh J, Double KL, Bobrovskaya L, Reyes S, Dunkley PR, Halliday GM, 'Distribution of tyrosine hydroxylase isoforms in the human brain', Journal of Neurochemistry, Busan, Korea (2009) [E3]
2009Rostas JA, Skelding KA, Liao X, Verrills NM, Dickson PW, 'Regulation of CaMKII by targeting', Proceedings of the 2nd Australia-China Biomedical Research Conference, - (2009) [E3]
2008Posser T, Franco JL, Bobrovskaya L, Leal RB, Dickson PW, Dunkley PR, 'Sustained tyrosine hydroxylase phosphorylation in pc12 cells exposed to manganese', Proceedings of the Australian Neuroscience Society, Hobart, TAS (2008) [E3]

Co-authors: Peter Dunkley

2008Skelding KA, Verrills NM, Fluechter L, Sim AT, Dickson PW, Rostas JA, 'Development of a novel method for the identification of CaMKII binding proteins', Journal of Neurochemistry, Shanghai, China (2008) [E3]
2008Gelain DP, Mareira JC, Bevilaqua LRM, Dickson PW, Dunkley PR, 'Retinol stimulates tyrosine hydroxylase activity by increasing ser40 phosphorylation in bovine adrenal chromaffin cells', Proceedings of the Australian Neuroscience Society, Hobart, TAS (2008) [E3]

Co-authors: Peter Dunkley

2008Lonergan T, Bobrovskaya L, Dunkley PR, Dickson PW, Pilowsky PM, Goodchild A, 'Intracellular signaling pathways in catecholaminergic cells activitated by glucoprivation', Proceedings of the Australian Neuroscience Society, Hobart, TAS (2008) [E3]

Co-authors: Peter Dunkley

2008Gelain DP, Moreira JC, Bevilaqua LRM, Dickson PW, Dunkley PR, 'Retinol stimulates tyrosine hydroxylase activity by increasing ser40 and then ser 31 phosphorylation in bovine adrenal chromaffin cells', Journal of Neurochemistry, Shanghai, China (2008) [E3]

Co-authors: Peter Dunkley

2008Skelding KA, Verrills NM, Fluechter L, Sim AT, Dickson PW, Rostas JA, 'Identification of CaMKII binding proteins in brain sensitive to CaMKII phosphorylation state', Proceedings of the Australian Neuroscience Society, Hobart, TAS (2008) [E3]
2007Bobrovskaya L, Gelain D, Gilligan C, Flaherty J, Bolster EK, Dickson PW, Dunkley PR, 'Nicotine and Pacap stimulate the sustained phosphorylation of tyrosine hydroxylase at serine 40 (Poster)', 7th IBRO 2007 World Congress of Neuroscience Program, Melbourne (2007) [E3]
2007Gordon SL, Quinsey NS, Dunkley PR, Dickson PW, 'Tyrosine hydroxylase activity is regulated by two distinct dopamine binding sites (Poster)', 7th IBRO 2007 World Congress of Neuroscience Program, Melbourne (2007) [E3]

Co-authors: Peter Dunkley

2007Gelain DP, Moreira JC, Bevilaqua LR, Dickson PW, Dunkley PR, 'Retinol stimulates tyrosine hydroxylase activity by increasing Ser40 phosphorylation in bovine adrenal chromaffin cells', JOURNAL OF NEUROCHEMISTRY, Cancun, MEXICO (2007)
2006Rostas JA, Migues PV, Fluechter L, Dickson PW, Sim AT, Rawoff S, et al., 'Phosphorylation of CAMKII at T253 induced by transient global ischaemia', Proceedings of the Australian Neuroscience Society, Sydney (2006) [E3]
2006Dunkley PR, Bobrovskaya L, Gilligan C, Bolster EK, Flaherty J, Dickson PW, 'Sustained phosphorylation of tyrosine hydroxylase at serine 40 is inhibited by the antidepressant imipramine', Proceedings of the Australian Neuroscience Society, Sydney, NSW (2006) [E3]
2006Lehmann IT, Bobrovskaya L, Dunkley PR, Dickson PW, 'Differential regulation of the human tyrosine hydroxylase isoforms via hierarchical phosphorylation', Proceedings of the Australian Neuroscience Society, Sydney (2006) [E3]

Co-authors: Peter Dunkley

2006Rostas JAP, Migues P, Lehmann IT, Fluechter L, Cammarota M, Gurd JW, et al., 'Phosphorylation of CAMKII at Thr253 occurs in vivo and enhances binding to isolated post synaptic densities', JOURNAL OF NEUROCHEMISTRY, Singapore, SINGAPORE (2006)
2005Dunkley PR, Bobrovskaya L, Gilligan C, Soster E, Dickson PW, 'Sustained phosphorylation of tyrosine hydroxylase at Ser40', JOURNAL OF NEUROCHEMISTRY, Innsbruck, AUSTRIA (2005) [E1]
2005Lehmann IT, Bobrovskaya L, Dunkley PR, Dickson PW, 'Phosphorylation of Ser31 increases the activation of tyrosine hydroxylase via hierarchical phosphorylation', JOURNAL OF NEUROCHEMISTRY, Innsbruck, AUSTRIA (2005) [E1]
2005Migues PV, Lehmann IT, Fluechter L, Cammarota M, Sim AT, Gurd JW, et al., 'Phosphorylation of CaMKII on T253 enhances its association with postsynaptic densities', JOURNAL OF NEUROCHEMISTRY, Innsbruck, AUSTRIA (2005)
2004Bobrovskaya L, Dunkley PR, Dickson PW, 'Phosphorylation of Ser19 increases both Ser40 phosphorylation and enzyme activity of tyrosine hydroxylase in intact cells', Journal of Neurochemistry, England (2004) [E1]
2004Dunkley PR, Bobrovskaya L, Dickson PW, Rose J, Lehmann IT, 'Hierarchical phosphorylation of tyrosine hydroxylase in bovine adrenal chromaffin cells', Journal of Neurochemistry, Hong Kong (2004) [E3]

Co-authors: Peter Dunkley

2004Bobrovskaya L, Bolster EK, Dickson PW, Dunkley PR, 'Angiotensin II-Stimulated phosphorylation of tyrosine hydroxylase in bovine adrenal chromaffin cells: The role of PKC isozymes', Proceedings of the Australian Neuroscience Society, Melbourne, Australia (2004) [E3]

Co-authors: Peter Dunkley

2003Bobrovskaya L, Dunkley PR, Dickson PW, 'Phosphorylation of Ser19 increases both Ser40 phosphorylation and enzyme activity of tyrosine hydroxylase in intact cells', JOURNAL OF NEUROCHEMISTRY, WANCHAI, PEOPLES R CHINA (2003) [E1]
2003Bobrovskaya L, Dickson PW, Dunkley PR, 'Hierarchical Phosphorylation of SER19 and SER40 on Tyrosine Hydroxylase in Bovine Adrenal Chromaffin Cells', Proccedings of the Australian Neuroscience Society, Adelaide, Australia (2003) [E3]

Co-authors: Peter Dunkley

2001Bevilaqua LRM, Graham ME, Von Nagy-Felsobuki EI, Dunkley RR, Dickson PW, 'Effect of phosphorylation on tyrosine hydroxylase shape', JOURNAL OF NEUROCHEMISTRY (2001) [E1]

Author URL

Co-authors: Ellak

2001Graham ME, Dickson PW, Dunkley PR, Von Nagy-Felsobuki EI, 'Quantification of phosphorylation levels of tyrosine hydroxylase utilkizing protein cleavage and electrospray mass spectrometry', Advances in Mass Spectrometry, Barcelona, Spain (2001) [E3]

Co-authors: Ellak, Peter Dunkley

Show 46 more
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Grants and Funding

Summary

Number of grants39
Total funding$4,294,918

- Indicates that the researcher may be seeking students for this project.

Click on a grant title below to expand the full details for that specific grant.

2014 (3 grants)

Expanding the Genomic Frontier - from Species to Strains and Individuals to Populations$150,000
Funding Body: University of Newcastle

Project Team
Professor Marc Wilkins, Professor Rick Cavicchioli, Professor Brett Neilan, Professor Rodney Scott, Professor Paul Foster, Associate Professor Phillip Dickson, Professor Ian Charles, Associate Professor Elizabeth Harry, Associate Professor Steven Djordjevic, Associate Professor Cynthia Whitchurch, Professor Ian Paulsen, Professor Nicolle Packer, Professor Michael Gillings
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$150,00020142014
GNo:G1300426

Expanding the Genomic Frontier - from Species to Strains and Individuals to Populations$128,147
Funding Body: ARC (Australian Research Council)

Project Team
Professor Marc Wilkins, Professor Rick Cavicchioli, Professor Brett Neilan, Professor Rodney Scott, Professor Paul Foster, Associate Professor Phillip Dickson, Professor Ian Paulsen, Professor Nicolle Packer, Professor Michael Gillings, Professor Ian Charles, Associate Professor Elizabeth Harry, Associate Professor Steven Djordjevic, Associate Professor Cynthia Whitchurch
SchemeRole
Linkage Infrastructure Equipment & Facilities (LIEF)Investigator
Total AmountFunding StartFunding Finish
$128,14720142014
GNo:G1301339

Role of infection in the development of Parkinson's Disease $125,679
Funding Body: Hunter Medical Research Institute

Project Team
Associate Professor Phillip Dickson, Emeritus Professor Peter Dunkley
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$125,67920142014
GNo:G1301295

2013 (3 grants)

Leica TP 1020 Automatic Tissue Processor for histology applications$35,000
Funding Body: NHMRC (National Health & Medical Research Council)

Ultra-Low Temperature Cryogenic Freezer$24,596
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Doctor Jude Weidenhofer, Doctor Rick Thorne, Doctor Kathryn Skelding, Doctor Nikki Verrills, Doctor Pradeep Tanwar, Associate Professor Phillip Dickson, Conjoint Associate Professor Murray Cairns, Professor Hubert Hondermarck, Professor Xu Dong Zhang, Associate Professor Estelle Sontag, Doctor Chen Chen Jiang, Associate Professor Liz Milward, Doctor Jean-Marie Sontag, Associate Professor Paul Tooney, Doctor Severine Roselli, Doctor Matt Dun, Doctor Chris Dayas, Doctor Lin Kooi Ong, Professor Dirk Van Helden, Mr Ben Copeland, Doctor Gabrielle Briggs, Emeritus Professor Leonie Ashman, Emeritus Professor John Rostas
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$24,59620132013
GNo:G1201189

42nd Annual Meeting of the Brazilian Society of Biochemistry and Molecular Biology, Brazil 18-21 May 13.$2,000
Funding Body: University of Newcastle - Faculty of Health and Medicine

Project Team
Associate Professor Phillip Dickson
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$2,00020132013
GNo:G1300791

2012 (4 grants)

Human tyrosine hydroxylase isoforms and susceptibility of dopaminergic neurons to degeneration in Parkinson's disease$354,601
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Associate Professor Phillip Dickson, Emeritus Professor Peter Dunkley, Associate Professor Kay Double
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$354,60120122014
GNo:G1100113

Regulation of the cell cycle by phosphorylation dependent targeting of CaMKII$20,000
Funding Body: University of Newcastle

Project Team
Doctor Nikki Verrills, Doctor Kathryn Skelding, Emeritus Professor John Rostas, Associate Professor Phillip Dickson, Conjoint Professor Keith Jones
SchemeRole
Near Miss GrantInvestigator
Total AmountFunding StartFunding Finish
$20,00020122012
GNo:G1200679

Role of CaMKII targeting in neuronal susceptibility to excitotoxic cell death$20,000
Funding Body: University of Newcastle

Project Team
Emeritus Professor John Rostas, Doctor Neil Spratt, Associate Professor Phillip Dickson, Doctor Nikki Verrills
SchemeRole
Near Miss GrantInvestigator
Total AmountFunding StartFunding Finish
$20,00020122012
GNo:G1200673

10th International catecholamine symposium, pacific Grove, California, 9 - 13 September 2012$1,862
Funding Body: University of Newcastle - Faculty of Health and Medicine

Project Team
Associate Professor Phillip Dickson
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$1,86220122012
GNo:G1200814

2011 (1 grants)

IMPLEN NanoPhotometer pearl$10,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Conjoint Associate Professor Murray Cairns, Associate Professor Paul Tooney, Associate Professor Alan Brichta, Emeritus Professor John Rostas, Emeritus Professor Patricia Michie, Conjoint Professor Keith Jones, Professor Ulli Schall, Associate Professor Phillip Dickson, Doctor Frederick Walker, Doctor Rick Thorne, Doctor Chris Dayas, Doctor Nikki Verrills, Doctor Janet Holt, Doctor Severine Roselli, Doctor Kathryn Skelding, Doctor Jude Weidenhofer, Associate Professor Liz Milward, Doctor Charles De Bock, Doctor Julie Merriman-Jones, Doctor Jing Qin Wu, Doctor Bing Liu, Mr Dan Johnstone, Ms Belinda Goldie, Ms Natalie Beveridge
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$10,00020112011
GNo:G1100030

2010 (2 grants)

Repair of the nigrostriatal pathway by phenotype shift of dopamine neurones$60,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Associate Professor Phillip Dickson, Professor Malcolm Horne
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$60,00020102012
GNo:G1000068

ABI 7500 Real Time PCR System $34,000
Funding Body: NHMRC (National Health & Medical Research Council)

2009 (2 grants)

An Advanced Mass Spectrometry Facility for Applications in Proteomics and Organic Chemistry$495,000
Funding Body: ARC (Australian Research Council)

An Advanced Mass Spectrometry Facility for Applications in Proteomics and Organic Chemistry$50,000
Funding Body: ARC (Australian Research Council)

2007 (2 grants)

Functional Characterisation of a New Regulatory Mechanism for CaMKII at Synapses in Vivo$526,500
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Emeritus Professor John Rostas, Associate Professor Phillip Dickson, Professor Alistair Sim
SchemeRole
Project GrantInvestigator
Total AmountFunding StartFunding Finish
$526,50020072009
GNo:G0186415

Differential regulation of human tyrosine hydroxylase isoforms and the development of Parkinson's disease$312,750
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Associate Professor Phillip Dickson, Emeritus Professor Peter Dunkley, Associate Professor Kay Double
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$312,75020072009
GNo:G0186394

2006 (4 grants)

PRC - Priority Research Centre for Bioinformatics, Biomarker Discovery & Information-Based Medicine (CIBM)$621,143
Funding Body: University of Newcastle

Project Team
Professor Pablo Moscato, Professor Rodney Scott, Emeritus Professor John Rostas, Professor John Forbes, Conjoint Professor Peter Hersey, Conjoint Professor Stephen Ackland, Conjoint Professor Wayne Smith, Emeritus Professor Peter Dunkley, Emeritus Professor Leonie Ashman, Professor John Attia, Associate Professor Phillip Dickson, Associate Professor Liz Milward, Professor Alistair Sim, Associate Professor Paul Tooney, Associate Professor Regina Berretta, Conjoint Professor David Sibbritt, Conjoint Professor Chris Levi, Professor Xu Dong Zhang, Conjoint Associate Professor Patricia Crock, Conjoint Associate Professor Jeannette Lechner-Scott
SchemeRole
Priority Research CentreInvestigator
Total AmountFunding StartFunding Finish
$621,14320062013
GNo:G0186919

Functional Characterisation of CaMKII Phosphorylate at a New Site in vivo$20,000
Funding Body: University of Newcastle

Project Team
Emeritus Professor John Rostas, Associate Professor Phillip Dickson, Professor Alistair Sim
SchemeRole
Near Miss GrantInvestigator
Total AmountFunding StartFunding Finish
$20,00020062006
GNo:G0186059

Differential regulation of human tyrosine hydroxyase isoforms and susceptibility of dopaminergic neurons to degeneration$10,000
Funding Body: University of Newcastle

Project Team
Associate Professor Phillip Dickson, Emeritus Professor Peter Dunkley, Associate Professor Kay Double
SchemeRole
Near Miss GrantChief Investigator
Total AmountFunding StartFunding Finish
$10,00020062006
GNo:G0186079

BioRad Mini-PROTEAN3 Electrophoresis system$995
Funding Body: Hunter Medical Research Institute

Project Team
Emeritus Professor Leonie Ashman, Associate Professor Phillip Dickson, Emeritus Professor Peter Dunkley, Emeritus Professor John Rostas, Professor Judith Scott, Professor Alistair Sim, Doctor Nikki Verrills
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$99520062006
GNo:G0187280

2005 (5 grants)

A novel mechanism for the maintenance of catecholamine synthesis$351,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Emeritus Professor Peter Dunkley, Associate Professor Phillip Dickson
SchemeRole
Project GrantInvestigator
Total AmountFunding StartFunding Finish
$351,00020052007
GNo:G0184211

High throughput proteomics - Thermo Finnigan ProteomeX LCQ Integrated Proteomicis Workstation$207,189
Funding Body: ARC (Australian Research Council)

Control of Dopamine synthesis and Parkinsons' disease$10,000
Funding Body: Hunter Medical Research Institute

Project Team
Associate Professor Phillip Dickson, Emeritus Professor Peter Dunkley
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$10,00020052005
GNo:G0185977

Regulation of Human Tyrosine Hydroxylase Isoforms by Hierarchical Phosphorylation$8,000
Funding Body: University of Newcastle

Project Team
Associate Professor Phillip Dickson, Emeritus Professor Peter Dunkley
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$8,00020052005
GNo:G0184779

ISN 20th Biennial Meeting of the International Society for Neurochemistry, 21-26 August 2005$2,160
Funding Body: University of Newcastle

Project Team
Associate Professor Phillip Dickson
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$2,16020052005
GNo:G0185672

2004 (2 grants)

Biacore3000-Expansion of Proteomics Facility$187,341
Funding Body: ARC (Australian Research Council)

Project Team
Professor Alistair Sim, Laureate Professor John Aitken, Emeritus Professor Peter Dunkley, Emeritus Professor John Rostas, Associate Professor Phillip Dickson, Emeritus Professor Leonie Ashman, Professor Roger Smith, Professor Gordon Burns, Professor Adam McCluskey, Associate Professor Paul Tooney, Dr Fraser Ross, Conjoint Professor Ray Rose
SchemeRole
Linkage Infrastructure Equipment & Facilities (LIEF)Investigator
Total AmountFunding StartFunding Finish
$187,34120042004
GNo:G0183030

Wide Gel Format Western Blot Apparatus for the Medical Biochemistry Group$4,140
Funding Body: Hunter Medical Research Institute

Project Team
Associate Professor Phillip Dickson
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$4,14020042004
GNo:G0184540

2003 (2 grants)

Hierarchical Phosphorylation of Tyrosine Hydroxylase is Dependent on the Activation Sequence of Signaling Pathways.$135,000
Funding Body: ARC (Australian Research Council)

Project Team
Associate Professor Phillip Dickson, Emeritus Professor Peter Dunkley
SchemeRole
Discovery ProjectsChief Investigator
Total AmountFunding StartFunding Finish
$135,00020032004
GNo:G0182096

Dephosphorylation of tyrosine hydroxylase$11,000
Funding Body: University of Newcastle

Project Team
Associate Professor Phillip Dickson
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$11,00020032003
GNo:G0182434

2002 (4 grants)

Control of catecholamine synthesis and secretion by angiotensin II$270,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Emeritus Professor Peter Dunkley, Associate Professor Phillip Dickson
SchemeRole
Project GrantInvestigator
Total AmountFunding StartFunding Finish
$270,00020022004
GNo:G0180883

Peltier Thermal Cycler and associated equipment essential for establishing cDNA Retroviral Libraries$21,315
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Emeritus Professor Leonie Ashman, Dr Petranel Ferrao, Professor Gordon Burns, Professor Alistair Sim, Emeritus Professor Peter Dunkley, Emeritus Professor John Rostas, Associate Professor Phillip Dickson, Professor Dirk Van Helden, Dr Perry Hartfield
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$21,31520022002
GNo:G0181919

Elucidation of the mechanism of tyrosine hydroxylase regulation by the use on mass spectrometry$12,000
Funding Body: University of Newcastle

Project Team
Associate Professor Phillip Dickson
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$12,00020022002
GNo:G0181403

Dephosphorylation of tyrosine hydroxylase in vitro and in vivo$11,000
Funding Body: University of Newcastle

Project Team
Associate Professor Phillip Dickson, Dr Martin Cammarota
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$11,00020022002
GNo:G0181404

2001 (1 grants)

Control of Catecholamine Synthesis by Tyrosine Hydroxylase.$13,000
Funding Body: University of Newcastle

Project Team
Emeritus Professor Peter Dunkley, Associate Professor Phillip Dickson, Emeritus Professor Ellak Von Nagy-Felsobuki, Professor Alistair Sim
SchemeRole
Project GrantInvestigator
Total AmountFunding StartFunding Finish
$13,00020012001
GNo:G0180125

2000 (2 grants)

Control of Catecholamine Synthesis by Tyrosine Hydroxylase.$14,500
Funding Body: ARC (Australian Research Council)

Project Team
Emeritus Professor Peter Dunkley, Associate Professor Phillip Dickson, Emeritus Professor Ellak Von Nagy-Felsobuki
SchemeRole
Small GrantInvestigator
Total AmountFunding StartFunding Finish
$14,50020002000
GNo:G0178980

Loss of control of dopamine synthesis and induction of neurodegeneration in Parkinson' Disease.$10,000
Funding Body: ARC (Australian Research Council)

Project Team
Associate Professor Phillip Dickson, Conjoint Professor David Powis
SchemeRole
Small GrantChief Investigator
Total AmountFunding StartFunding Finish
$10,00020002000
GNo:G0178912

1999 (2 grants)

FPLC Protein Purification System$16,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Alistair Sim, Emeritus Professor John Rostas, Emeritus Professor Peter Dunkley, Associate Professor Phillip Dickson
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$16,00019991999
GNo:G0180790

Development of a cellular model to study regulation of neurotransmitter synthesis$9,000
Funding Body: University of Newcastle

Project Team
Associate Professor Phillip Dickson, Emeritus Professor Peter Dunkley
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$9,00019991999
GNo:G0178050
Edit

Research Supervision

Number of current supervisions1
Total current UoN PhD EFTSL0.6

For supervisions undertaken at an institution other that the University of Newcastle, the institution name is listed below the program name.

Current Supervision

CommencedProposed
Completion
ProgramSupervisor TypeResearch Title
20112015PhD (Medical Biochemistry)Principal SupervisorThe Interaction of Tyrosine Hydroxylase with Alpha Synuclein: a Role in Parkinson's Disease

Past Supervision

YearProgramSupervisor TypeResearch Title
2013M Philosophy (Medical Biochem)Co-SupervisorEffects of Multi-site Phosphorylation on CaMKII Function
2013PhD (Medical Biochemistry)Principal SupervisorInvestigation of Catecholamine Inhibition in Tyrosine Hydroxylase
2012PhD (Medical Biochemistry)Co-SupervisorNeurobiological Consequences of Stress: Tyrosine Hydroxylase Phosphorylation in Response to Stress
2010PhD (Medical Biochemistry)Principal SupervisorDifferential Distribution of Tyrosine Hydroxylase Isoforms and Phosphorylation in Parkinson Disease
2009PhD (Medical Biochemistry)Principal SupervisorAcute Regulation of Tyrosine Hydroxylase
Edit

Associate Professor Phillip Dickson

Work Phone(02) 4921 7031
Fax(02) 4921 6903
Email
PositionAssociate Professor
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine
The University of Newcastle, Australia
Focus AreaMedical Biochemistry
Office
LS3-47,
Life Sciences Building,
Callaghan
University Drive
Callaghan NSW 2308
Australia
URL:www.newcastle.edu.au/profile/phil-dickson