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Associate Professor Phillip Dickson

Associate Professor

School of Biomedical Sciences and Pharmacy (Medical Biochemistry)

Career Summary

Biography

Research Expertise
The focus of my work has been the enzyme tyrosine hydroxylase which controls the rate of synthesis of the catecholamines dopamine, noradrenaline and adrenaline. I have examined the control of tyrosine hydroxylase activity by phosphorylation and have shown that hierarchical phosphorylation(the phosphorylation one site affecting the rate of phosphorylation of another site on the same molecule) exists in tyrosine hydroxylase and plays an important role in the control of tyrosine hydroxylase activity. More recently my work has focused on how this regulation of tyrosine hydroxylase plays a role in Parkinson's disease. We have now found that there is a selective loss of one of the human TH isoforms in Parkinson's disease. Therefore the expression of particular TH isoforms may render the cells more susceptible to death in Parkinson's disease.

Teaching Expertise
The focus of my teaching has been biochemistry and molecular biology. I have taught into the general areas of cell organelle structure, enzymology, cell communication and signal transduction, DNA replication, DNA transcription and protein synthesis and molecular biological techniques.

Administrative Expertise
I was the foundation program coordinator for the Bachelor of Biomedical Sciences Honours program. Since 2004 I have been Head of the Discipline of Medical Biochemistry and in 2006 took up the position as the Research Higher Degrees Coordinator for the School of Biomedical Sciences. I have been a member of both the School Research Executive and the School Teaching Committee. In 2009 I was appointed Deputy Head of School in charge of infrastructure.

Qualifications

  • PhD, University of Melbourne
  • Bachelor of Science (Honours), University of Melbourne

Keywords

  • Parkinson's disease
  • catecholamines
  • cellular biochemistry
  • dopamine
  • hierarchical phosphorylation
  • molecular biology
  • signal transduction
  • tyrosine hydroxylase

Fields of Research

Code Description Percentage
110199 Medical Biochemistry and Metabolomics not elsewhere classified 40
060199 Biochemistry and Cell Biology not elsewhere classified 35
110999 Neurosciences not elsewhere classified 25

Professional Experience

UON Appointment

Title Organisation / Department
Associate Professor University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia

Invitations

Participant

Year Title / Rationale
2006 13th International Symposium on Chromaffin Cell Biology
Organisation: International Society for Neurochemistry (ISN) Description: Invited speaker to the conference
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Chapter (1 outputs)

Year Citation Altmetrics Link
2013 Dickson PW, Briggs GD, 'Tyrosine hydroxylase. Regulation by feedback inhibition and phosphorylation.', Advances in Pharmacology: A New Era of Catecholamines in the Laboratory and Clinic, Academic Press, San Diego 13-21 (2013) [B1]
DOI 10.1016/B978-0-12-411512-5.00002-6
Citations Scopus - 3

Journal article (45 outputs)

Year Citation Altmetrics Link
2015 Quinn RK, Brown AL, Goldie BJ, Levi EM, Dickson PW, Smith DW, et al., 'Distinct miRNA expression in dorsal striatal subregions is associated with risk for addiction in rats.', Transl Psychiatry, 5 e503 (2015)
DOI 10.1038/tp.2014.144
Co-authors Murray Cairns, Christopher Dayas
2014 James MH, Quinn RK, Ong LK, Levi EM, Charnley JL, Smith DW, et al., 'mTORC1 inhibition in the nucleus accumbens 'protects' against the expression of drug seeking and 'relapse' and is associated with reductions in GluA1 AMPAR and CAMKIIa levels.', Neuropsychopharmacology, 39 1694-1702 (2014) [C1]
DOI 10.1038/npp.2014.16
Citations Scopus - 2
Co-authors Christopher Dayas, Douglas Smith, Linkooi Ong
2014 Briggs GD, Bulley J, Dickson PW, 'Catalytic domain surface residues mediating catecholamine inhibition in tyrosine hydroxylase', Journal of Biochemistry, 155 183-193 (2014) [C1]
DOI 10.1093/jb/mvt110
Citations Scopus - 1
2014 Ong LK, Guan L, Damanhuri H, Goodchild AK, Bobrovskaya L, Dickson PW, Dunkley PR, 'Neurobiological consequences of acute footshock stress: effects on tyrosine hydroxylase phosphorylation and activation in the rat brain and adrenal medulla', JOURNAL OF NEUROCHEMISTRY, 128 547-560 (2014) [C1]
DOI 10.1111/jnc.12482
Citations Scopus - 3Web of Science - 2
Co-authors Peter Dunkley, Linkooi Ong
2014 Stutz B, Lima da Conceicao FS, Santos LE, Cadilhe DV, Fleming RL, Acquarone M, et al., 'Murine dopaminergic Muller cells restore motor function in a model of Parkinson's disease', JOURNAL OF NEUROCHEMISTRY, 128 829-840 (2014) [C1]
DOI 10.1111/jnc.12475
Citations Scopus - 2Web of Science - 2
Co-authors Peter Dunkley
2014 Hoffman A, Carpenter H, Kahl R, Watt LF, Dickson PW, Rostas JAP, et al., 'Dephosphorylation of CaMKII at T253 controls the metaphase-anaphase transition', Cellular Signalling, 26 748-756 (2014) [C1]

Calcium/calmodulin-stimulated protein kinase II (CaMKII) is a multi-functional serine/threonine protein kinase that controls a range of cellular functions, including proliferation... [more]

Calcium/calmodulin-stimulated protein kinase II (CaMKII) is a multi-functional serine/threonine protein kinase that controls a range of cellular functions, including proliferation. The biological properties of CaMKII are regulated by multi-site phosphorylation and targeting via interactions with specific proteins. To investigate the role specific CaMKII phosphorylation sites play in controlling cell proliferation and cell cycle progression, we examined phosphorylation of CaMKII at two sites (T253 and T286) at various stages of the cell cycle, and also examined the effects of overexpression of wild-type (WT), T286D phosphomimic, T253D phosphomimic and T253V phosphonull forms of CaMKIIa in MDA-MB-231 breast cancer and SHSY5Y neuroblastoma cells on cellular proliferation and cell cycle progression. We demonstrate herein that whilst there is no change in total CaMKII expression or T286 phosphorylation throughout the cell cycle, a marked dephosphorylation of CaMKII at T253 occurs during the G2 and/or M phases. Additionally, we show by molecular inhibition, as well as pharmacological activation, that protein phosphatase 2A (PP2A) is the phosphatase responsible for this dephosphorylation. Furthermore, we show that inducible overexpression of WT, T286D and T253V forms of CaMKIIa in MDA-MB-231 and SHSY5Y cells increases cellular proliferation, with no alteration in cell cycle profiles. By contrast, overexpression of a T253D phosphomimic form of CaMKIIa significantly decreases proliferation, and cells accumulate in mitosis, specifically in metaphase. Taken together, these results strongly suggest that the dephosphorylation of CaMKII at T253 is involved in controlling the cell cycle, specifically the metaphase-anaphase transition. © 2014 Elsevier Inc.

DOI 10.1016/j.cellsig.2013.12.015
Citations Scopus - 2Web of Science - 1
Co-authors Kathryn Skelding, John Rostas, Nikki Verrills
2014 Abdul Majeed ABB, Pearsall E, Carpenter H, Brzozowski J, Dickson PW, Rostas JAP, Skelding KA, 'CaMKII Kinase Activity, Targeting and Control of Cellular Functions: Effect of Single and Double Phosphorylation of CaMKIIa', Calcium Signaling, 1 36-51 (2014) [C1]
Co-authors Kathryn Skelding, John Rostas
2013 Briggs G, Bulley J, Dunkley PR, Dickson PW, 'Structural Basis for Regulation of Tyrosine Hydroxlyase by the Catecholamines 8-9 (2013) [E3]
DOI 10.1016/B978-0-12-800044-1.00006-4
Co-authors Peter Dunkley
2013 Briggs GD, Nagy GM, Dickson PW, 'Mechanism of action of salsolinol on tyrosine hydroxylase', Neurochemistry International, 63 726-731 (2013) [C1]

Tyrosine hydroxylase (TH) is the first and rate-limiting enzyme in dopamine synthesis. Dopamine regulates TH as an end-product inhibitor through its binding to a high and low affi... [more]

Tyrosine hydroxylase (TH) is the first and rate-limiting enzyme in dopamine synthesis. Dopamine regulates TH as an end-product inhibitor through its binding to a high and low affinity site, the former being abolished by Ser40 phosphorylation only, and the latter able to bind and dissociate according to intracellular dopamine levels. Here, we have investigated TH inhibition by a dopamine metabolite found in dopaminergic brain regions, salsolinol (SAL). SAL is known to decrease dopamine in the nigrostriatal pathway and mediobasal hypothalamus, and to also decrease plasma catecholamines in rat stress models, however a target and mechanism for the effects of SAL have not been found. We found that SAL inhibits TH activity in the nanomolar range in vitro, by binding to both the high and low affinity dopamine binding sites. SAL produces the same level of inhibition as dopamine when TH is non-phosphorylated. However, it produces 3.7-fold greater inhibition of Ser40-phosphorylated TH compared to dopamine by competing more strongly with tetrahydrobiopterin, the cofactor of this enzymatic reaction. SAL's potent inhibition of phosphorylated TH would prevent TH from being fully activated to synthesise dopamine. Crown Copyright © 2013 Published by Elsevier Ltd. All rights reserved.

DOI 10.1016/j.neuint.2013.09.016
Citations Scopus - 2Web of Science - 1
2013 Sominsky L, Fuller EA, Bondarenko E, Ong LK, Averell L, Nalivaiko E, et al., 'Functional Programming of the Autonomic Nervous System by Early Life Immune Exposure: Implications for Anxiety', PLOS ONE, 8 (2013) [C1]
DOI 10.1371/journal.pone.0057700
Citations Scopus - 11Web of Science - 10
Co-authors Deborah Hodgson, Peter Dunkley, Eugene Nalivaiko, Linkooi Ong
2012 Skelding KA, Dickson PW, Verrills NM, Rostas JA, 'Progression through mitosis can be controlled by dephosphorylation of CaMKII at T253', JOURNAL OF NEUROCHEMISTRY, 123 31-31 (2012) [E3]
Co-authors Nikki Verrills, John Rostas, Kathryn Skelding
2012 Majeed ABA, Rostas JAP, Carpenter H, Dickson PW, Skelding KA, 'Multi-site phosphorylation of CaMKII regulates CaMKII function co-operatively', JOURNAL OF NEUROCHEMISTRY, 123 116-116 (2012) [E3]
Co-authors John Rostas, Kathryn Skelding
2012 Skelding KA, Spratt NJ, Fluechter L, Dickson PW, Rostas JA, 'alpha CaMKII is differentially regulated in brain regions that exhibit differing sensitivities to ischemia and excitotoxicity', Journal of Cerebral Blood Flow and Metabolism, 32 2181-2192 (2012) [C1]
Citations Scopus - 5Web of Science - 6
Co-authors Neil Spratt, Kathryn Skelding, John Rostas
2012 Ong LK, Sominsky L, Dickson PW, Hodgson DM, Dunkley PR, 'The sustained phase of Tyrosine hydroxylase activation in vivo', Neurochemical Research, 37 1938-1943 (2012) [C1]
Citations Scopus - 6Web of Science - 5
Co-authors Peter Dunkley, Linkooi Ong, Deborah Hodgson
2012 Damanhuri HA, Burke PGR, Ong LK, Bobrovskaya L, Dickson PW, Dunkley PR, Goodchild AK, 'Tyrosine hydroxylase phosphorylation in catecholaminergic brain regions: A marker of activation following acute hypotension and glucoprivation', Plos One, 7 1-19 (2012) [C1]
Citations Scopus - 10Web of Science - 8
Co-authors Linkooi Ong, Peter Dunkley
2011 Briggs GD, Gordon SL, Dickson PW, 'Mutational analysis of catecholamine binding in tyrosine hydroxylase', Biochemistry, 50 1545-1555 (2011) [C1]
DOI 10.1021/bi101455b
Citations Scopus - 8Web of Science - 6
2011 Aumann TD, Egan K, Lim J, Boon WC, Bye CR, Chua HK, et al., 'Neuronal activity regulates expression of tyrosine hydroxylase in adult mouse substantia nigra pars compacta neurons', Journal of Neurochemistry, 116 646-658 (2011) [C1]
DOI 10.1111/j.1471-4159.2010.07151.x
Citations Scopus - 12Web of Science - 10
2011 Ong LK, Guan L, Stutz B, Dickson PW, Dunkley PR, Bobrovskaya L, 'The effects of footshock and immobilization stress on tyrosine hydroxylase phosphorylation in the rat locus coeruleus and adrenal gland', Neuroscience, 192 20-27 (2011) [C1]
DOI 10.1016/j.neuroscience.2011.06.087
Citations Scopus - 7Web of Science - 7
Co-authors Linkooi Ong, Peter Dunkley
2011 Ong LK, Bobrovskaya L, Walker FR, Day TA, Dickson PW, Dunkley PR, 'The effect of social defeat on tyrosine hydroxylase phosphorylation in the rat brain and adrenal gland', Neurochemical Research, 36 27-33 (2011) [C1]
DOI 10.1007/s11064-010-0255-7
Citations Scopus - 7Web of Science - 7
Co-authors Linkooi Ong, Peter Dunkley, Rohan Walker
2010 Bobrovskaya L, Damanhuri HA, Ong LK, Schneider JJ, Dickson PW, Dunkley PR, Goodchild AK, 'Signal transduction pathways and tyrosine hydroxylase regulation in the adrenal medulla following glucoprivation: An in vivo analysis', Neurochemistry International, 57 162-167 (2010) [C1]
DOI 10.1016/j.neuint.2010.05.009
Citations Scopus - 11Web of Science - 11
Co-authors Peter Dunkley, Linkooi Ong, Jennifer Schneider
2010 Double KL, Halliday GM, Dunkley PR, Dickson PW, Gerlach M, Riederer P, 'Pigmentation in the human brain and risk of Parkinson's Disease', Annals of Neurology, 67 553-554 (2010) [C3]
Citations Scopus - 2Web of Science - 1
Co-authors Peter Dunkley
2010 Posser T, Dunkley PR, Dickson PW, Franco JL, 'Human neuroblastoma cells transfected with tyrosine hydroxylase gain increased resistance to methylmercury-induced cell death', Toxicology in Vitro, 24 1498-1503 (2010) [C1]
DOI 10.1016/j.tiv.2010.07.015
Citations Scopus - 8Web of Science - 9
Co-authors Peter Dunkley
2010 Skelding KA, Suzuki T, Gordon SL, Xue J, Verrills NM, Dickson PW, Rostas JA, 'Regulation of CaMKII by phospho-Thr253 or phospho-Thr286 sensitive targeting alters cellular function', Cellular Signalling, 22 759-769 (2010) [C1]
DOI 10.1016/j.cellsig.2009.12.011
Citations Scopus - 9Web of Science - 9
Co-authors John Rostas, Kathryn Skelding, Nikki Verrills
2010 Franco JL, Posser T, Gordon SL, Bobrovskaya L, Schneider JJ, Farina M, et al., 'Expression of tyrosine hydroxylase increases the resistance of human neuroblastoma cells to oxidative insults', Toxicological Sciences, 113 150-157 (2010) [C1]
DOI 10.1093/toxsci/kfp245
Citations Scopus - 10Web of Science - 9
Co-authors Jennifer Schneider, Peter Dunkley
2009 Posser T, Franco JL, Bobrovskaya L, Leal RB, Dickson PW, Dunkley PR, 'Manganese induces sustained Ser40 phosphorylation and activation of tyrosine hydroxylase in PC12 cells', Journal of Neurochemistry, 110 848-856 (2009) [C1]
DOI 10.1111/j.1471-4159.2009.06185.x
Citations Scopus - 18Web of Science - 14
Co-authors Peter Dunkley
2009 Gordon SL, Bobrovskaya L, Dunkley PR, Dickson PW, 'Differential regulation of human tyrosine hydroxylase isoforms 1 and 2 in situ: Isoform 2 is not phosphorylated at Ser35', Biochimica et Biophysica Acta - Molecular Cell Research, 1793 1860-1867 (2009) [C1]
DOI 10.1016/j.bbamcr.2009.10.001
Citations Scopus - 21Web of Science - 21
Co-authors Peter Dunkley
2009 Gordon SL, Webb JK, Shehadeh J, Dunkley PR, Dickson PW, 'The low affinity dopamine binding site on tyrosine hydroxylase: The role of the N-Terminus and in situ regulation of enzyme activity', Neurochemical Research, 34 1830-1837 (2009) [C1]
DOI 10.1007/s11064-009-9989-5
Citations Scopus - 7Web of Science - 6
Co-authors Peter Dunkley
2009 Franco JL, Posser T, Dunkley PR, Dickson PW, Mattos JJ, Martins R, et al., 'Methylmercury neurotoxicity is associated with inhibition of the antioxidant enzyme glutathione peroxidase', Free Radical Biology and Medicine, 47 449-457 (2009) [C1]
DOI 10.1016/j.freeradbiomed.2009.05.013
Citations Scopus - 70Web of Science - 66
Co-authors Peter Dunkley
2008 Gordon SL, Quinsey NS, Dunkley PR, Dickson PW, 'Tyrosine hydroxylase activity is regulated by two distinct dopamine-binding sites', Journal of Neurochemistry, 106 1614-1623 (2008) [C1]
DOI 10.1111/j.1471-4159.2008.05509.x
Citations Scopus - 19Web of Science - 18
Co-authors Peter Dunkley
2007 Bobrovskaya L, Gelain DP, Gilligan C, Dickson PW, Dunkley PR, 'PACAP stimulates the sustained phosphorylation of tyrosine hydroxylase at serine 40', Cellular Signalling, 19 1141-1149 (2007) [C1]
DOI 10.1016/j.cellsig.2006.12.006
Citations Web of Science - 33
Co-authors Conor Gilligan, Peter Dunkley
2007 Bobrovskaya L, Gilligan C, Bolster EK, Flaherty JJ, Dickson PW, Dunkley PR, 'Sustained phosphorylation of tyrosine hydroxylase at serine 40: a novel mechanism for maintenance of catecholamine synthesis', Journal of Neurochemistry, 100 479-489 (2007) [C1]
DOI 10.1111/j.1471-4159.2006.04213.x
Citations Scopus - 49Web of Science - 48
Co-authors Peter Dunkley, Conor Gilligan
2007 Gelain DP, Moreira JCF, Bevilaqua LRM, Dickson PW, Dunkley PR, 'Retinol activates tyrosine hydroxylase acutely by increasing the phosphorylation of serine40 and then serine31 in bovine adrenal chromaffin cells', Journal of Neurochemistry, 103 2369-2379 (2007) [C1]
DOI 10.1111/j.1471-4159.2007.04935.x
Citations Scopus - 15Web of Science - 14
Co-authors Peter Dunkley
2006 Migues PV, Lehmann IT, Fluechter L, Cammarota MP, Gurd JW, Sim AT, et al., 'Phosphorylation of CaMKII at Thr253 occurs in vivo and enhances binding to isolated postsynaptic densities', Journal of Neurochemistry, 98 289-299 (2006) [C1]
DOI 10.1111/j.1471-4159.2006.03876.x
Citations Scopus - 24Web of Science - 22
Co-authors Alistair Sim, John Rostas
2006 Lehmann IT, Bobrovskaya L, Gordon SL, Dunkley PR, Dickson PW, 'Differential regulation of the human tyrosine hydroxylase isoforms via hierarchical phosphorylation', Journal of Biological Chemistry, 281 17644-17651 (2006) [C1]
DOI 10.1074/jbc.M512194200
Citations Scopus - 45Web of Science - 45
Co-authors Peter Dunkley
2005 Graham ME, Dickson PW, Dunkley PR, Von Nagy-Felsobuki EI, 'Characterisation of tryptic peptides of phosphorylated tyrosine hydroxylase by high-pressure liquid chromatography electrospray ionisation mass spectrometry', Journal of Electron Spectroscopy and Related Phenomena, 142 271-276 (2005) [C1]
DOI 10.1016/j.elspec.2004.09.008
Citations Scopus - 2Web of Science - 2
Co-authors Ellak, Peter Dunkley
2004 Dunkley PR, Bobrovskaya L, Graham ME, Von Nagy-Felsobuki EI, Dickson PW, 'Tyrosine hydroxylase phosphorylation: regulation and consequences', Journal of Neurochemistry, 91 1025-1043 (2004) [C1]
DOI 10.1111/j.1471-4159.2004.02797.x
Citations Scopus - 229Web of Science - 229
Co-authors Ellak, Peter Dunkley
2003 Bevilaqua L, Cammarota MP, Dickson PW, Sim AT, Dunkley PR, 'Role of protein phosphatase 2C from bovine adrenal chromaffin cells in the dephosphorylation of phospho-serine 40 tyrosine hydroxylase', Journal of Neurochemistry, 85 1368-1373 (2003) [C1]
DOI 10.1046/j.1471-4159.2003.01792.x
Citations Scopus - 18Web of Science - 18
Co-authors Alistair Sim, Peter Dunkley
2001 Bevilaqua L, Graham ME, Dunkley PR, Von Nagy-Felsobuki EI, Dickson PW, 'Phosphorylation of Ser19 Alters the Conformation of Tyrosine Hydroxylase to Increase the Rate of Phosphorylation of Ser40*', The Journal of Biological Chemistry, 276 No. 44 40411-40416 (2001) [C1]
Citations Scopus - 62Web of Science - 63
Co-authors Peter Dunkley
2001 Bevilaqua L, Graham ME, Von Nagy-Felsobuki EI, Dunkley PR, Dickson PW, 'Effect of phosphorylation on tyrosine hydroxylase shape', Journal of Neurochemistry, 78 Supt. 1 143 (2001) [C3]
Co-authors Peter Dunkley
2001 Graham ME, Bevilaqua L, Dunkley PR, Von Nagy-Felsobuki EI, Dickson PW, 'The Kinetics of CAMKII Phosphorylation of Dopamine Bound-Tyrosine Hydroxylase Determined by Electrospray Mass Spectrometry', ComBio 2001, 0 (2001) [C3]
Co-authors Peter Dunkley
2000 Graham ME, Dickson PW, Dunkley PR, Von Nagy-Felsobuki EI, 'Determination of Phosphorylation Levels of Tyrosine Hydroxylase by Electrospray Mass Spectrometry', Analytical Biochemistry, 280 1-7 (2000) [C1]
Citations Web of Science - 8
Co-authors Peter Dunkley, Ellak
1999 Dickson PW, Wong Z, Harrap S, Abramson M, Walters E, 'Mutational analysis of the high affinity immunoglobulin E receptor Beta subunit gene in asthma', Thorax (The Journal of the British Thoracic Society), 54 409-412 (1999) [C1]
Citations Scopus - 19Web of Science - 17
1998 Quinsey NS, Luong AQ, Dickson PW, 'Mutational analysis of substrate inhibition in tyrosine hydroxylase', Journal of Neurochemistry, 71 2132-2138 (1998) [C1]
Citations Scopus - 13Web of Science - 12
1998 Graham ME, Dickson PW, Dunkley PR, Von Nagy-Felsobuki EI, 'Characterisation of the phosphorylation of rat tyrosine hydroxylase using electrospray mass spectrometry', Rapid Communications in Mass Spectrometry, 12 746-748 (1998) [C1]
Co-authors Peter Dunkley
1998 Graham ME, Dickson P, Dunkley P, Von Nagy-Felsobuki EI, 'Characterization of the Phosphorylation of Rat Tyrosine Hydroxylase using Electrospray Mass Spectrometry', Rapid Communications in Mass Spectrometry, 12 746-748 (1998) [C1]
Citations Web of Science - 6
Co-authors Ellak, Peter Dunkley
Show 42 more journal articles

Conference (49 outputs)

Year Citation Altmetrics Link
2014 Ong LK, Briggs GD, Dunkley PR, Dickson PW, 'The role of inflammation and dopamine synthesis in Parkinson's disease', JOURNAL OF NEUROCHEMISTRY, Kaohsiung, TAIWAN (2014) [E3]
Co-authors Peter Dunkley, Linkooi Ong
2013 Skelding KA, Majeed ABA, Carpenter H, Dickson PW, Rostas JA, 'Can functional outcomes of CaMKII double phosphorylation be predicted from outcomes following single phosphorylation of CaMKII?', JOURNAL OF NEUROCHEMISTRY, Cancun, MEXICO (2013) [E3]
Co-authors John Rostas, Kathryn Skelding
2013 Guan L, Werno M, Gordon SL, Dunkley P, Dickson PW, 'The effect of tyrosine hydroxylase on alpha-synuclein aggregation', JOURNAL OF NEUROCHEMISTRY, Cancun, MEXICO (2013) [E3]
Co-authors Peter Dunkley
2012 Skelding KA, Abdul Majeed ABB, Dickson PW, Spratt NJ, Rostas JA, 'CAMKII is regulated differently in brains regions with differing sensitivities to ischaemia/excitotoxicity', Abstracts. Australian Neuroscience Society 32nd Annual Meeting, Gold Coast, Queensland (2012) [E3]
Co-authors Kathryn Skelding, John Rostas, Neil Spratt
2012 Briggs GD, Smith T, Hickey S, Dickson PW, 'A channel extending from the catalytic cleft of tyrosine hydroxylase is involved in high affinity catecholamine inhibition', Abstracts. Australian Neuroscience Society 32nd Annual Meeting, Gold Coast, Queensland (2012) [E3]
2012 Skelding KA, Dickson PW, Verrills NM, Rostas JA, 'Dephosphorylation of CAMKII at T253 controls progression through metaphase', Abstracts. Australian Neuroscience Society 32nd Annual Meeting, Gold Coast, Queensland (2012) [E3]
Co-authors Kathryn Skelding, John Rostas, Nikki Verrills
2012 Abdul Majeed ABB, Skelding KA, Dickson PW, Rostas JA, 'Does phosphorylation of CaMKII at multiple sites regulate CaMKII targeting co-operatively or independently?', Abstracts. Australian Neuroscience Society 32nd Annual Meeting, Gold Coast, Queensland (2012) [E3]
Co-authors John Rostas, Kathryn Skelding
2012 Guan L, Werno M, Gordon SL, Dunkley PR, Dickson PW, 'Effect of tyrosine hydroxylase on alphasynuclein aggregation', Abstracts. Australian Neuroscience Society 32nd Annual Meeting, Gold Coast, Queensland (2012) [E3]
Co-authors Peter Dunkley
2012 James MH, Charnley JL, Levi EM, Dunkley PR, Smith DW, Dickson PW, Dayas CV, 'A role for the mTOR pathway in the development of addiction', Abstracts. Australian Neuroscience Society 32nd Annual Meeting, Gold Coast, Queensland (2012) [E3]
Co-authors Douglas Smith, Peter Dunkley, Christopher Dayas
2012 Rostas JA, Skelding KA, Fluechter L, Dickson PW, Spratt NJ, 'CaMKII is Differentially Regulated in Striatum and Cortex', JOURNAL OF NEUROCHEMISTRY (2012) [E3]
Co-authors John Rostas, Kathryn Skelding, Neil Spratt
2012 Ong LK, Guan L, Bobrovskaya L, Dickson PW, Dunkley PR, 'Neurobiological consequences of acute footshock stress', Journal of Neurochemistry, Kobe, Japan (2012) [E3]
Co-authors Peter Dunkley, Linkooi Ong
2012 Rostas JA, Skelding KA, Fluechter L, Dickson PW, Spratt NJ, 'CaMKII is differentially regulated in striatum and cortex', Journal of Molecular Neuroscience: Abstracts The 21st Annual Meeting of the Israel Society for Neuroscience & The First Binational Australian-Israeli Meeting in Neuroscience, Eilat, Israel (2012) [E3]
Co-authors Kathryn Skelding, Neil Spratt, John Rostas
2010 Ong LK, Guan L, Stutz B, Dickson PW, Dunkley PR, Bobrovskaya L, 'Tyrosine hydroxylase phosphorylation in response to footshock and restraint stress', Journal of Neurochemistry, Phuket, Thailand (2010) [E3]
DOI 10.1093/jac/dkq221
Citations Scopus - 1
Co-authors Peter Dunkley, Linkooi Ong
2010 Skelding KA, Verrills NM, Dickson PW, Rostas JA, 'Regulation of proliferation of neuroblastoma cells by CaMKII', Proceding of the Australian Neuroscience Society, Sydney, NSW (2010) [E3]
Co-authors Kathryn Skelding, Nikki Verrills, John Rostas
2010 Skelding KA, Xue J, Suzuki T, Verrills NM, Dickson PW, Rostas JA, 'Mechanisms of phosphorylation-sensitive CaMKII targeting', Proceding of the Australian Neuroscience Society, Sydney, NSW (2010) [E3]
Co-authors Kathryn Skelding, Nikki Verrills, John Rostas
2009 Bobrovskaya L, Damanhuri H, Ong LK, Dickson PW, Dunkley PR, Goodchild AK, 'The effect of glucoprivation on tyrosine hydroxylase phosphorylation in adrenals of Sprague-Dawley rats', Autonomic Neuroscience: Basic and Clinical, Sydney, NSW (2009) [E3]
DOI 10.1016/j.autneu.2009.05.191
Co-authors Peter Dunkley, Linkooi Ong
2009 Bobrovskaya L, Ong LK, Walker RA, Day TA, Dickson PW, Dunkley PR, 'The effect of social stress on tyrosine hydroxylase phosphorylation', ANS 2009 Abstracts: Posters, Canberra, ACT (2009) [E3]
Co-authors Peter Dunkley, Linkooi Ong
2009 Gordon SL, Dunkley PR, Dickson PW, 'The low affinity dopamine binding site regulates tyrosine hydroxylase activity in situ: Implications for the regulation of cytosolic catecholamine levels', ANS 2009 Abstracts: Posters, Canberra, ACT (2009) [E3]
Co-authors Peter Dunkley
2009 Briggs GD, Gordon SL, Dunkley PR, Dickson PW, 'Localisation of the low affinity catecholamine binding site in tyrosine hydroxylase', ANS 2009 Abstracts: Posters, Canberra, ACT (2009) [E3]
Co-authors Peter Dunkley
2009 Skelding KA, Liao X, Verrills NM, Fluechter L, Sim AT, Dickson PW, Rostas JA, 'Functional consequences of CaMKII phosphorylation at THR253 in neurons', ANS 2009 Abstracts: Posters, Canberra, ACT (2009) [E3]
Co-authors Alistair Sim, Nikki Verrills, John Rostas, Kathryn Skelding
2009 Rostas JA, Skelding KA, Liao X, Verrills NM, Dickson PW, 'Regulation of CaMKII by targeting', Proceedings of the 2nd Australia-China Biomedical Research Conference, - (2009) [E3]
Co-authors Kathryn Skelding, John Rostas, Nikki Verrills
2009 Gordon SL, Bobrovskaya L, Dunkley PR, Dickson PW, 'Differential regulation of the two major isoforms of human tyrosine hydroxylase in situ', Journal of Neurochemistry, Busan, Korea (2009) [E3]
DOI 10.1111/j.1471-4159.2009.06242.x
Co-authors Peter Dunkley
2009 Skelding KA, Liao X, Verrills NM, Fluechter L, Dickson PW, Rostas JA, 'CaMKII phosphorylation at T253 alters neuronal growth rates and morphology', Journal of Neurochemistry, Busan, Korea (2009) [E3]
DOI 10.1111/j.1471-4159.2009.06238.x
Co-authors Kathryn Skelding, Nikki Verrills, John Rostas
2009 Ong LK, Bobrovskaya L, Walker FR, Day TA, Dickson PW, Dunkley PR, 'The effect of social conflict on tyrosine hydroxylase phosphorylation in catecholamine-producing cells from sprague-dawley rats', Journal of Neurochemistry, Busan, Korea (2009) [E3]
DOI 10.1111/j.1471-4159.2009.06242.x
Co-authors Peter Dunkley, Rohan Walker, Linkooi Ong
2009 Dickson PW, Shehadeh J, Double KL, Bobrovskaya L, Reyes S, Dunkley PR, Halliday GM, 'Distribution of tyrosine hydroxylase isoforms in the human brain', Journal of Neurochemistry, Busan, Korea (2009) [E3]
DOI 10.1111/j.1471-4159.2009.06239.x
Co-authors Peter Dunkley
2009 Shehadeh J, Double K, Murphy K, Bobrovskaya L, Reyes S, Dunkley PR, et al., 'Differential distribution of tyrosine hydroxylase isoforms in the human brain', Parkinsonism & Related Disorders, Miami Beach, FL (2009) [E3]
Co-authors Peter Dunkley
2008 Gelain DP, Mareira JC, Bevilaqua LRM, Dickson PW, Dunkley PR, 'Retinol stimulates tyrosine hydroxylase activity by increasing ser40 phosphorylation in bovine adrenal chromaffin cells', Proceedings of the Australian Neuroscience Society, Hobart, TAS (2008) [E3]
Co-authors Peter Dunkley
2008 Lonergan T, Bobrovskaya L, Dunkley PR, Dickson PW, Pilowsky PM, Goodchild A, 'Intracellular signaling pathways in catecholaminergic cells activitated by glucoprivation', Proceedings of the Australian Neuroscience Society, Hobart, TAS (2008) [E3]
Co-authors Peter Dunkley
2008 Posser T, Franco JL, Bobrovskaya L, Leal RB, Dickson PW, Dunkley PR, 'Sustained tyrosine hydroxylase phosphorylation in pc12 cells exposed to manganese', Proceedings of the Australian Neuroscience Society, Hobart, TAS (2008) [E3]
Co-authors Peter Dunkley
2008 Skelding KA, Verrills NM, Fluechter L, Sim AT, Dickson PW, Rostas JA, 'Identification of CaMKII binding proteins in brain sensitive to CaMKII phosphorylation state', Proceedings of the Australian Neuroscience Society, Hobart, TAS (2008) [E3]
Co-authors Alistair Sim, Nikki Verrills, Kathryn Skelding, John Rostas
2008 Gelain DP, Moreira JC, Bevilaqua LRM, Dickson PW, Dunkley PR, 'Retinol stimulates tyrosine hydroxylase activity by increasing ser40 and then ser 31 phosphorylation in bovine adrenal chromaffin cells', Journal of Neurochemistry, Shanghai, China (2008) [E3]
Co-authors Peter Dunkley
2008 Skelding KA, Verrills NM, Fluechter L, Sim AT, Dickson PW, Rostas JA, 'Development of a novel method for the identification of CaMKII binding proteins', Journal of Neurochemistry, Shanghai, China (2008) [E3]
Co-authors Alistair Sim, John Rostas, Kathryn Skelding, Nikki Verrills
2007 Bobrovskaya L, Gelain D, Gilligan C, Flaherty J, Bolster EK, Dickson PW, Dunkley PR, 'Nicotine and Pacap stimulate the sustained phosphorylation of tyrosine hydroxylase at serine 40 (Poster)', 7th IBRO 2007 World Congress of Neuroscience Program, Melbourne (2007) [E3]
Co-authors Conor Gilligan, Peter Dunkley
2007 Gordon SL, Quinsey NS, Dunkley PR, Dickson PW, 'Tyrosine hydroxylase activity is regulated by two distinct dopamine binding sites (Poster)', 7th IBRO 2007 World Congress of Neuroscience Program, Melbourne (2007) [E3]
Co-authors Peter Dunkley
2007 Gelain DP, Moreira JC, Bevilaqua LR, Dickson PW, Dunkley PR, 'Retinol stimulates tyrosine hydroxylase activity by increasing Ser40 phosphorylation in bovine adrenal chromaffin cells', JOURNAL OF NEUROCHEMISTRY, Cancun, MEXICO (2007)
Co-authors Peter Dunkley
2006 Rostas JAP, Migues P, Lehmann IT, Fluechter L, Cammarota M, Gurd JW, et al., 'Phosphorylation of CAMKII at Thr253 occurs in vivo and enhances binding to isolated post synaptic densities', JOURNAL OF NEUROCHEMISTRY, Singapore, SINGAPORE (2006)
Co-authors John Rostas
2006 Dunkley PR, Bobrovskaya L, Gilligan C, Bolster EK, Flaherty J, Dickson PW, 'Sustained phosphorylation of tyrosine hydroxylase at serine 40 is inhibited by the antidepressant imipramine', Proceedings of the Australian Neuroscience Society, Sydney, NSW (2006) [E3]
Co-authors Peter Dunkley, Conor Gilligan
2006 Lehmann IT, Bobrovskaya L, Dunkley PR, Dickson PW, 'Differential regulation of the human tyrosine hydroxylase isoforms via hierarchical phosphorylation', Proceedings of the Australian Neuroscience Society, Sydney (2006) [E3]
Co-authors Peter Dunkley
2006 Rostas JA, Migues PV, Fluechter L, Dickson PW, Sim AT, Rawoff S, et al., 'Phosphorylation of CAMKII at T253 induced by transient global ischaemia', Proceedings of the Australian Neuroscience Society, Sydney (2006) [E3]
Co-authors Alistair Sim, John Rostas
2005 Dunkley PR, Bobrovskaya L, Gilligan C, Soster E, Dickson PW, 'Sustained phosphorylation of tyrosine hydroxylase at Ser40', JOURNAL OF NEUROCHEMISTRY, Innsbruck, AUSTRIA (2005) [E1]
Co-authors Peter Dunkley, Conor Gilligan
2005 Lehmann IT, Bobrovskaya L, Dunkley PR, Dickson PW, 'Phosphorylation of Ser31 increases the activation of tyrosine hydroxylase via hierarchical phosphorylation', JOURNAL OF NEUROCHEMISTRY, Innsbruck, AUSTRIA (2005) [E1]
Co-authors Peter Dunkley
2005 Migues PV, Lehmann IT, Fluechter L, Cammarota M, Sim AT, Gurd JW, et al., 'Phosphorylation of CaMKII on T253 enhances its association with postsynaptic densities', JOURNAL OF NEUROCHEMISTRY, Innsbruck, AUSTRIA (2005)
Co-authors John Rostas
2004 Bobrovskaya L, Dunkley PR, Dickson PW, 'Phosphorylation of Ser19 increases both Ser40 phosphorylation and enzyme activity of tyrosine hydroxylase in intact cells', Journal of Neurochemistry, England (2004) [E1]
DOI 10.1111/j.1471-4159.2004.02550.x
Citations Scopus - 40Web of Science - 42
Co-authors Peter Dunkley
2004 Bobrovskaya L, Bolster EK, Dickson PW, Dunkley PR, 'Angiotensin II-Stimulated phosphorylation of tyrosine hydroxylase in bovine adrenal chromaffin cells: The role of PKC isozymes', Proceedings of the Australian Neuroscience Society, Melbourne, Australia (2004) [E3]
Co-authors Peter Dunkley
2004 Dunkley PR, Bobrovskaya L, Dickson PW, Rose J, Lehmann IT, 'Hierarchical phosphorylation of tyrosine hydroxylase in bovine adrenal chromaffin cells', Journal of Neurochemistry, Hong Kong (2004) [E3]
Co-authors Peter Dunkley
2003 Bobrovskaya L, Dickson PW, Dunkley PR, 'Hierarchical Phosphorylation of SER19 and SER40 on Tyrosine Hydroxylase in Bovine Adrenal Chromaffin Cells', Proccedings of the Australian Neuroscience Society, Adelaide, Australia (2003) [E3]
Co-authors Peter Dunkley
2003 Bobrovskaya L, Dunkley PR, Dickson PW, 'Phosphorylation of Ser19 increases both Ser40 phosphorylation and enzyme activity of tyrosine hydroxylase in intact cells', JOURNAL OF NEUROCHEMISTRY, WANCHAI, PEOPLES R CHINA (2003) [E1]
Co-authors Peter Dunkley
2001 Graham ME, Dickson PW, Dunkley PR, Von Nagy-Felsobuki EI, 'Quantification of phosphorylation levels of tyrosine hydroxylase utilkizing protein cleavage and electrospray mass spectrometry', Advances in Mass Spectrometry, Barcelona, Spain (2001) [E3]
Co-authors Peter Dunkley, Ellak
2001 Bevilaqua LRM, Graham ME, Von Nagy-Felsobuki EI, Dunkley RR, Dickson PW, 'Effect of phosphorylation on tyrosine hydroxylase shape', JOURNAL OF NEUROCHEMISTRY (2001) [E1]
Co-authors Ellak
Show 46 more conferences
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Grants and Funding

Summary

Number of grants 41
Total funding $4,487,592

Click on a grant title below to expand the full details for that specific grant.


20151 grants / $1,000

1st Neurodegeneration and dementia conference, Melbourne Brian Centre Australia, 20 - 21 August 2015$1,000

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Associate Professor Phillip Dickson
Scheme Travel Grant
Role Lead
Funding Start 2015
Funding Finish 2015
GNo G1501073
Type Of Funding Internal
Category INTE
UON Y

20144 grants / $595,500

Role of infection in the development of Parkinson's Disease $245,679

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Associate Professor Phillip Dickson, Emeritus Professor Peter Dunkley
Scheme Project Grant
Role Lead
Funding Start 2014
Funding Finish 2014
GNo G1301295
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Expanding the Genomic Frontier - from Species to Strains and Individuals to Populations$150,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Marc Wilkins, Professor Rick Cavicchioli, Professor Brett Neilan, Professor Rodney Scott, Laureate Professor Paul Foster, Associate Professor Phillip Dickson, Professor Ian Charles, Associate Professor Elizabeth Harry, Associate Professor Steven Djordjevic, Associate Professor Cynthia Whitchurch, Professor Ian Paulsen, Professor Nicolle Packer, Professor Michael Gillings
Scheme Equipment Grant
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1300426
Type Of Funding Internal
Category INTE
UON Y

Expanding the Genomic Frontier - from Species to Strains and Individuals to Populations$128,147

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Professor Marc Wilkins, Professor Rick Cavicchioli, Professor Brett Neilan, Professor Rodney Scott, Laureate Professor Paul Foster, Associate Professor Phillip Dickson, Professor Ian Paulsen, Professor Nicolle Packer, Professor Michael Gillings, Professor Ian Charles, Associate Professor Elizabeth Harry, Associate Professor Steven Djordjevic, Associate Professor Cynthia Whitchurch
Scheme Linkage Infrastructure Equipment & Facilities (LIEF)
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1301339
Type Of Funding Scheme excluded from IGS
Category EXCL
UON Y

JuLI Stage $71,674

Funding body: NHMRC (National Health & Medical Research Council)

20133 grants / $61,596

42nd Annual Meeting of the Brazilian Society of Biochemistry and Molecular Biology, Brazil 18-21 May 13.$2,000

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Associate Professor Phillip Dickson
Scheme Travel Grant
Role Lead
Funding Start 2013
Funding Finish 2013
GNo G1300791
Type Of Funding Internal
Category INTE
UON Y

20124 grants / $396,463

Human tyrosine hydroxylase isoforms and susceptibility of dopaminergic neurons to degeneration in Parkinson's disease$354,601

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Associate Professor Phillip Dickson, Emeritus Professor Peter Dunkley, Associate Professor Kay Double
Scheme Project Grant
Role Lead
Funding Start 2012
Funding Finish 2012
GNo G1100113
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Role of CaMKII targeting in neuronal susceptibility to excitotoxic cell death$20,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Emeritus Professor John Rostas, Doctor Neil Spratt, Associate Professor Phillip Dickson, Doctor Nikki Verrills
Scheme Near Miss Grant
Role Investigator
Funding Start 2012
Funding Finish 2012
GNo G1200673
Type Of Funding Internal
Category INTE
UON Y

Regulation of the cell cycle by phosphorylation dependent targeting of CaMKII$20,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Doctor Nikki Verrills, Doctor Kathryn Skelding, Emeritus Professor John Rostas, Associate Professor Phillip Dickson, Conjoint Professor Keith Jones
Scheme Near Miss Grant
Role Investigator
Funding Start 2012
Funding Finish 2012
GNo G1200679
Type Of Funding Internal
Category INTE
UON Y

10th International catecholamine symposium, pacific Grove, California, 9 - 13 September 2012$1,862

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Associate Professor Phillip Dickson
Scheme Travel Grant
Role Lead
Funding Start 2012
Funding Finish 2012
GNo G1200814
Type Of Funding Internal
Category INTE
UON Y

20111 grants / $10,000

IMPLEN NanoPhotometer pearl$10,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Associate Professor Murray Cairns, Associate Professor Paul Tooney, Professor Alan Brichta, Emeritus Professor John Rostas, Emeritus Professor Patricia Michie, Conjoint Professor Keith Jones, Professor Ulli Schall, Associate Professor Phillip Dickson, Doctor Frederick Walker, Doctor Rick Thorne, Doctor Chris Dayas, Doctor Nikki Verrills, Doctor Janet Holt, Doctor Severine Roselli, Doctor Kathryn Skelding, Doctor Jude Weidenhofer, Associate Professor Liz Milward, Doctor Charles De Bock, Doctor Julie Merriman-Jones, Doctor Jing Qin Wu, Doctor Bing Liu, Mr Dan Johnstone, Ms Belinda Goldie, Doctor Natalie Beveridge
Scheme Equipment Grant
Role Investigator
Funding Start 2011
Funding Finish 2011
GNo G1100030
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

20102 grants / $94,000

Repair of the nigrostriatal pathway by phenotype shift of dopamine neurones$60,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Associate Professor Phillip Dickson, Professor Malcolm Horne
Scheme Project Grant
Role Lead
Funding Start 2010
Funding Finish 2010
GNo G1000068
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

ABI 7500 Real Time PCR System $34,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Doctor Rick Thorne, Doctor Nikki Verrills, Conjoint Associate Professor Murray Cairns, Associate Professor Paul Tooney, Doctor Doug Smith, Professor Gordon Burns, Emeritus Professor Leonie Ashman, Conjoint Professor Keith Jones, Doctor Charles De Bock, Doctor Chris Dayas, Doctor Brett Graham, Doctor Martin Horan, Doctor Rebecca Lim, Doctor Severine Roselli, Doctor Larisa Bobrovskaya, Doctor Kathryn Skelding, Doctor Frederick Walker, Doctor Jude Weidenhofer, Associate Professor Philip Bolton, Professor Alan Brichta, Professor Robert Callister, Professor Trevor Day, Associate Professor Phillip Dickson, Professor Manohar Garg, Doctor Phil Jobling, Associate Professor Derek Laver, Associate Professor Eugene Nalivaiko, Emeritus Professor John Rostas
Scheme Equipment Grant
Role Investigator
Funding Start 2010
Funding Finish 2010
GNo G1000055
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

20092 grants / $545,000

20072 grants / $839,250

Functional Characterisation of a New Regulatory Mechanism for CaMKII at Synapses in Vivo$526,500

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Emeritus Professor John Rostas, Associate Professor Phillip Dickson, Professor Alistair Sim
Scheme Project Grant
Role Investigator
Funding Start 2007
Funding Finish 2007
GNo G0186415
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Differential regulation of human tyrosine hydroxylase isoforms and the development of Parkinson's disease$312,750

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Associate Professor Phillip Dickson, Emeritus Professor Peter Dunkley, Associate Professor Kay Double
Scheme Project Grant
Role Lead
Funding Start 2007
Funding Finish 2007
GNo G0186394
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

20064 grants / $652,138

Functional Characterisation of CaMKII Phosphorylate at a New Site in vivo$20,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Emeritus Professor John Rostas, Associate Professor Phillip Dickson, Professor Alistair Sim
Scheme Near Miss Grant
Role Investigator
Funding Start 2006
Funding Finish 2006
GNo G0186059
Type Of Funding Internal
Category INTE
UON Y

Differential regulation of human tyrosine hydroxyase isoforms and susceptibility of dopaminergic neurons to degeneration$10,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Associate Professor Phillip Dickson, Emeritus Professor Peter Dunkley, Associate Professor Kay Double
Scheme Near Miss Grant
Role Lead
Funding Start 2006
Funding Finish 2006
GNo G0186079
Type Of Funding Internal
Category INTE
UON Y

BioRad Mini-PROTEAN3 Electrophoresis system$995

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Emeritus Professor Leonie Ashman, Associate Professor Phillip Dickson, Emeritus Professor Peter Dunkley, Emeritus Professor John Rostas, Professor Judith Scott, Professor Alistair Sim, Doctor Nikki Verrills
Scheme Equipment Grant
Role Investigator
Funding Start 2006
Funding Finish 2006
GNo G0187280
Type Of Funding Not Known
Category UNKN
UON Y

20055 grants / $578,349

A novel mechanism for the maintenance of catecholamine synthesis$351,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Emeritus Professor Peter Dunkley, Associate Professor Phillip Dickson
Scheme Project Grant
Role Investigator
Funding Start 2005
Funding Finish 2005
GNo G0184211
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Control of Dopamine synthesis and Parkinsons' disease$10,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Associate Professor Phillip Dickson, Emeritus Professor Peter Dunkley
Scheme Project Grant
Role Lead
Funding Start 2005
Funding Finish 2005
GNo G0185977
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Regulation of Human Tyrosine Hydroxylase Isoforms by Hierarchical Phosphorylation$8,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Associate Professor Phillip Dickson, Emeritus Professor Peter Dunkley
Scheme Project Grant
Role Lead
Funding Start 2005
Funding Finish 2005
GNo G0184779
Type Of Funding Internal
Category INTE
UON Y

ISN 20th Biennial Meeting of the International Society for Neurochemistry, 21-26 August 2005$2,160

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Associate Professor Phillip Dickson
Scheme Travel Grant
Role Lead
Funding Start 2005
Funding Finish 2005
GNo G0185672
Type Of Funding Internal
Category INTE
UON Y

20042 grants / $191,481

Biacore3000-Expansion of Proteomics Facility$187,341

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Professor Alistair Sim, Laureate Professor John Aitken, Emeritus Professor Peter Dunkley, Emeritus Professor John Rostas, Associate Professor Phillip Dickson, Emeritus Professor Leonie Ashman, Professor Roger Smith, Professor Gordon Burns, Professor Adam McCluskey, Associate Professor Paul Tooney, Dr Fraser Ross, Conjoint Professor Ray Rose
Scheme Linkage Infrastructure Equipment & Facilities (LIEF)
Role Investigator
Funding Start 2004
Funding Finish 2004
GNo G0183030
Type Of Funding Scheme excluded from IGS
Category EXCL
UON Y

Wide Gel Format Western Blot Apparatus for the Medical Biochemistry Group$4,140

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Associate Professor Phillip Dickson
Scheme Project Grant
Role Lead
Funding Start 2004
Funding Finish 2004
GNo G0184540
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

20032 grants / $146,000

Hierarchical Phosphorylation of Tyrosine Hydroxylase is Dependent on the Activation Sequence of Signaling Pathways.$135,000

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Associate Professor Phillip Dickson, Emeritus Professor Peter Dunkley
Scheme Discovery Projects
Role Lead
Funding Start 2003
Funding Finish 2003
GNo G0182096
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Dephosphorylation of tyrosine hydroxylase$11,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Associate Professor Phillip Dickson
Scheme Project Grant
Role Lead
Funding Start 2003
Funding Finish 2003
GNo G0182434
Type Of Funding Internal
Category INTE
UON Y

20024 grants / $314,315

Control of catecholamine synthesis and secretion by angiotensin II$270,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Emeritus Professor Peter Dunkley, Associate Professor Phillip Dickson
Scheme Project Grant
Role Investigator
Funding Start 2002
Funding Finish 2002
GNo G0180883
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Peltier Thermal Cycler and associated equipment essential for establishing cDNA Retroviral Libraries$21,315

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Emeritus Professor Leonie Ashman, Dr Petranel Ferrao, Professor Gordon Burns, Professor Alistair Sim, Emeritus Professor Peter Dunkley, Emeritus Professor John Rostas, Associate Professor Phillip Dickson, Professor Dirk Van Helden, Dr Perry Hartfield
Scheme Equipment Grant
Role Investigator
Funding Start 2002
Funding Finish 2002
GNo G0181919
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Elucidation of the mechanism of tyrosine hydroxylase regulation by the use on mass spectrometry$12,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Associate Professor Phillip Dickson
Scheme Project Grant
Role Lead
Funding Start 2002
Funding Finish 2002
GNo G0181403
Type Of Funding Internal
Category INTE
UON Y

Dephosphorylation of tyrosine hydroxylase in vitro and in vivo$11,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Associate Professor Phillip Dickson, Dr Martin Cammarota
Scheme Project Grant
Role Lead
Funding Start 2002
Funding Finish 2002
GNo G0181404
Type Of Funding Internal
Category INTE
UON Y

20011 grants / $13,000

Control of Catecholamine Synthesis by Tyrosine Hydroxylase.$13,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Emeritus Professor Peter Dunkley, Associate Professor Phillip Dickson, Emeritus Professor Ellak Von Nagy-Felsobuki, Professor Alistair Sim
Scheme Project Grant
Role Investigator
Funding Start 2001
Funding Finish 2001
GNo G0180125
Type Of Funding Internal
Category INTE
UON Y

20002 grants / $24,500

Control of Catecholamine Synthesis by Tyrosine Hydroxylase.$14,500

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Emeritus Professor Peter Dunkley, Associate Professor Phillip Dickson, Emeritus Professor Ellak Von Nagy-Felsobuki
Scheme Small Grant
Role Investigator
Funding Start 2000
Funding Finish 2000
GNo G0178980
Type Of Funding Scheme excluded from IGS
Category EXCL
UON Y

Loss of control of dopamine synthesis and induction of neurodegeneration in Parkinson' Disease.$10,000

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Associate Professor Phillip Dickson, Conjoint Professor David Powis
Scheme Small Grant
Role Lead
Funding Start 2000
Funding Finish 2000
GNo G0178912
Type Of Funding Scheme excluded from IGS
Category EXCL
UON Y

19992 grants / $25,000

FPLC Protein Purification System$16,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Alistair Sim, Emeritus Professor John Rostas, Emeritus Professor Peter Dunkley, Associate Professor Phillip Dickson
Scheme Equipment Grant
Role Investigator
Funding Start 1999
Funding Finish 1999
GNo G0180790
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Development of a cellular model to study regulation of neurotransmitter synthesis$9,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Associate Professor Phillip Dickson, Emeritus Professor Peter Dunkley
Scheme Project Grant
Role Lead
Funding Start 1999
Funding Finish 1999
GNo G0178050
Type Of Funding Internal
Category INTE
UON Y
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Research Supervision

Number of supervisions

Completed6
Current1

Total current UON EFTSL

PhD0.6

Current Supervision

Commenced Level of Study Research Title / Program / Supervisor Type
2015 PhD Role of Inflammation in Parkinson's Disease
Medical Science, Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor

Past Supervision

Year Level of Study Research Title / Program / Supervisor Type
2015 PhD Regulation of Tyrosine Hydroxylase in Stress and Parkinson's Disease
Medical Science, Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2013 PhD Investigation of Catecholamine Inhibition in Tyrosine Hydroxylase
Medical Science, Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2013 Masters Effects of Multi-site Phosphorylation on CaMKII Function
Medical Science, Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2012 PhD Neurobiological Consequences of Stress: Tyrosine Hydroxylase Phosphorylation in Response to Stress
Medical Science, Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2010 PhD Differential Distribution of Tyrosine Hydroxylase Isoforms and Phosphorylation in Parkinson Disease
Medical Science, Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2009 PhD Acute Regulation of Tyrosine Hydroxylase
Medical Science, Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
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Associate Professor Phillip Dickson

Position

Associate Professor
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

Focus area

Medical Biochemistry

Contact Details

Email phil.dickson@newcastle.edu.au
Phone (02) 4921 7031
Fax (02) 4921 6903

Office

Room LS3-47
Building Life Sciences Building
Location Callaghan
University Drive
Callaghan, NSW 2308
Australia
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