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Conjoint Professor Peter Wark

Conjoint Professor

School of Medicine and Public Health (Immunology and Microbiology)

Career Summary

Biography

Peter Wark is a senior staff specialist in Respiratory and Sleep Medicine at John Hunter Hospital, Newcastle and a conjoint Associate Professor with the University of Newcastle. In addition he is co-director of the Priority Research Centre for Asthma and Respiratory Diseases and a member of the Vaccines Immunology Viruses and Asthma research group at the Hunter Medical Research Institute. He has been a member of the TSANZ executive board since and chairman of the clinical care and resources subcommittee since 2011.

His research interests are in the area of infection and the impact this has on inflammatory airways disease, with a particular interest in viral respiratory infections. His group has developed expertise in identifying respiratory viruses in airway secretions and developing an in-vitro cell culture model of the airway epithelium that we use to model the effect of infection and inflammation. He is the centre director for the John Hunter Adult Cystic Fibrosis clinic that manages 75 adult patients with CF in the context of a multidisciplinary team. He is area director for the oxygen and related products scheme and lead physician for the advanced respiratory failure clinic. He is chairperson for the Hunter New England Local Hospital network respiratory stream, responsible for the provision of respiratory services throughout the Hunter New England area, with a catchment population of 840,000.

Peter qualified as a Bachelor of Medicine at the University of Newcastle, Australia in 1991 and qualified as a specialist in Respiratory and Sleep Medicine as a Fellow of the Royal Australasian College of Physicians in 1999. From 2001-2005 he was a post doctoral research fellow under an NHMRC Neil Hamilton Fairley Travelling Fellowship at the University of Southampton and University College London, under the supervision of Professors Stephen Holgate, Donna Davies and Sebastian Johnston. From 1998-2001 he completed a PhD under the supervision of Professors Peter Gibson and Michael Hensley at the University of Newcastle, Australia. Peter is married to Katrina, and parents to Kirsty, Marden, Jasmine, Sarah, David, Charlotte and Eliza.

Research Expertise
My current research interests include the role of virus infection in acute exacerbations of airways disease and their influence on airway inflammation. Active research programmes include the investigation of innate immune function of the airway epithelium in response to virus infection and the interaction with other components of the cellular immune system. These projects involve the use of invitro cell culture models to study mechanisms of disease and inflammation especially in respect to viral and bacterial infection, the isolation, sequencing and characterisation of respiratory viruses from clinical specimens. Clinical studies currently focus on the effect of infection in acute exacerbations of asthma, COPD and cystic fibrosis lung disease. I undertook a post-doctoral research project that is collaboration between Professor Stephen Holgate and Professor Sebastian Johnston. The project is titled “Mechanisms of bronchial epithelial cell activation in response to rhinovirus infection in asthma COPD and normal airways. The aim is to characterise the response and interaction of cultured human bronchial epithelial and mesenchymal cells to experimental rhinovirus infection. The aim is to contrast and compare the inflammatory and reparative response in cells from subjects with varying severities of asthma, COPD and normal controls. During this time I have established expertise with in-vitro culture of tissue cell lines and primary bronchial epithelial cells. In collaboration with Professor Sebastian Johnston I have also established techniques that have enabled me to culture Rhinovirus and infect epithelial cells. We assessed the cytotoxic effect of infection on epithelial cells and determined the mechanisms of cell death using flow cytometry and Annexin binding. In addition the inflammatory response between asthmatic epithelial cells and healthy controls was compared in terms of release of pro-inflammatory mediators, type I interferons and factors that may influence myofibroblast proliferation, by measuring mRNA production using quantifiable PCR in conjunction with protein expression as measured by ELISA. This data has presented at international meetings and is awaiting publication. In the last eighteen months we have received further funding from the UK National Asthma Campaign and the British Medical Association to extend this work examining the effect of infection on an epithelial-mesenchymal co-culture model to determine if there is a relationship between infection and airway wall remodelling and are exploring in greater detail early epithelial intracellular signalling events following infection, particularly in reference to oxidative pathways and interferon ?/? signalling. My research group specialises in: 1. Primary airway epithelial cell culture, especially in regard to responses to infection and inflammation. 2. Basic mechanisms of innate immune responses pathways, with an emphaisis on epithelial cell responses, dendritic cell responses and innate lymphoid responses. 3. Innate and adaptive immune responses to respiratory virus infection, with a special interest in influenza and rhinovirus

Teaching Expertise
Supervison of honours and PhD students in the areas airway inflammation, infection and respiratory disease. I am responsible for funding and supervising 2.0 FTE research assistants and 2.0 FTE post-doctoral research fellows. I have supervised two students who have completed and been awarded their PhD, 2 further students who have completed their doctoral studies and will submit their thesis in 2012 and 3 students that completed their honours year. I am currently the primary supervisor for two PhD students and a secondary supervisor for another three. For the School of Medicine and Public Health, Faculty of Health, University of Newcastle I have regular lecture commitments to years 2, 3, 4 and 5. In addition I act as a clinical tutor for students in year 3, 4 and 5. My direct University teaching commitments are 2.5 hours per week. Supervision of post graduate students: I currently supervise 3 students enrolled in PhDs and one student enrolled in a masters degree with the Faculty of Health, University of Newcastle. I have supervised the following students that have completed and been awarded PhD with the University of Newcastle. 1. Dr Rebecca Forbes awarded 2012 2. Dr Alan Hsu, awarded 2011 2. Dr Shen Yun Adeline Foo, awarded 2011 3. Dr Ahmed Saedsomaelia, awarded 2009 I have supervised the following students that have completed and been awarded honours with the University of Newcastle. 1. Ms Su Ling Loo, First class Honours awarded 2010. 2. Ms Hayley See,


Collaborations
Our clinical studies currently focus on the effect of infection in acute exacerbations of asthma, COPD and cystic fibrosis lung disease. Ongoing clinical research programmes are active with Prof Peter Gibson, Dr L Wood. We are currently taking part in a multi-centre RCt of non-CF bronchiectasis in collaboration with Royal Prince Alfred Hospital Sydney and Prince Charles Hospital Brisbane. We are an active site involved in the national influenza surveillance programme "Flucan". This works involves an effective collaboration between other members of the VIVA group and priority research centre in the areas of clinical research and translational research using animal models with Prof P Hansbro, Prof J Mattes, Prof P Forster. We have an active NHMRC grant looking at the immunology and susceptibility of virus infection in pregnancy with Prof R Smith.


Qualifications

  • PhD, University of Newcastle
  • Bachelor of Medicine, University of New South Wales

Keywords

  • Airway inflammation
  • Asthma
  • COPD
  • Immunolgy
  • Internal medicine
  • Respiratory Medicine
  • Sleep medicine
  • Virology

Fields of Research

CodeDescriptionPercentage
110799Immunology not elsewhere classified25
110203Respiratory Diseases50
110804Medical Virology25

Professional Experience

UON Appointment

DatesTitleOrganisation / Department
6/08/2002 - 1/08/2003Neil Hamilton Fairley FellowshipUniversity of Newcastle
School of Medicine and Public Health
Australia

Academic appointment

DatesTitleOrganisation / Department
1/01/2010 - Editor - Clinical and Experimental AllergyClinical and Experimental Allergy
Australia
1/01/2005 - Conjoint Associate ProfessorUniversity of Newcastle
School of Medicine and Public Health
Australia
1/01/2003 - Fellow - American Thoracic SocietyAmerican Thoracic Society
United States
1/01/2000 - Editor - Cochrane CollaborationCochrane Collaboration
United Kingdom
1/01/1996 - Fellow - Thoracic Society of Australia and New ZealandThe Thoracic Society of Australia and New Zealand
Australia
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Chapter (4 outputs)

YearCitationAltmetricsLink
2014Hsu A, Zhong H, Hansbro P, Wark P, 'Innate Immunity in the Airways to Respiratory Viruses', Virology II - Advanced Issues, iConcept Press, Hong Kong 1-32 (2014) [B1]
Author URL
Co-authorsAlan Hsu, Philip Hansbro
2014Hsu A, Loo S, Fathi Aghdam F, Parsons K, Hansbro P, Wark P, 'Airway Epithelial and Early Innate Immune Responses to Virus Infections', Human Respiratory Viral Infections, CRC Press, Boca Raton, FL 29-44 (2014) [B1]
DOI10.1201/b16778-5Author URL
Co-authorsPhilip Hansbro, Alan Hsu
2011Wark PA, Hayes M, 'Respiratory examination', Clinical Examination: A Problem Based Approach, World Scientific Publishing, Singapore 17-40 (2011) [B2]
2010Wark PA, Gibson PG, 'Pathogenesis of ABPA', Aspergillosis: From diagnosis to prevention, Springer, Berlin 695-706 (2010) [B1]
Co-authorsPeter Gibson
Show 1 more chapter

Journal article (73 outputs)

YearCitationAltmetricsLink
2015Vanders RL, Murphy VE, Gibson PG, Hansbro PM, Wark PAB, 'CD8 T cells and dendritic cells: Key players in the attenuated maternal immune response to influenza infection', Journal of Reproductive Immunology, 107 1-9 (2015)

Pregnancy provides a unique challenge for maternal immunity, requiring the ability to tolerate the presence of a semi-allogeneic foetus, and yet still being capable of inducing an immune response against invading pathogens. To achieve this, numerous changes must occur in the activity and function of maternal immune cells throughout the course of pregnancy. Respiratory viruses take advantage of these changes, altering the sensitive balance of maternal immunity, leaving the mother with increased susceptibility to viral infections and increased disease severity. Influenza virus is one of the most common respiratory virus infections during pregnancy, leading to an increased risk of ICU hospitalisations, pneumonia, acute respiratory distress syndrome and even death. Whilst much research has been performed to understand the changes that must take place in maternal immunity during pregnancy, considerable work is still needed to fully comprehend this tremendous feat. To date, few studies have focused on the alterations that occur in maternal immunity during respiratory virus infections. This review highlights the role of dendritic cells (DCs) and CD8 T cells during pregnancy, and the changes that occur in these antiviral cells following influenza virus infections.

DOI10.1016/j.jri.2014.09.051
Co-authorsPhilip Hansbro, Vanessa Murphy, Peter Gibson
2015Kumar RK, Shadie AM, Bucknall MP, Rutlidge H, Garthwaite L, Herbert C, et al., 'Differential injurious effects of ambient and traffic-derived particulate matter on airway epithelial cells', RESPIROLOGY, 20 73-79 (2015)
DOI10.1111/resp.12381Author URL
CitationsWeb of Science - 1
2015Chen-Yu Hsu A, Starkey MR, Hanish I, Parsons K, Haw TJ, Howland LJ, et al., 'Targeting PI3K-p110a Suppresses Influenza Virus Infection in Chronic Obstructive Pulmonary Disease.', Am J Respir Crit Care Med, 191 1012-1023 (2015)
DOI10.1164/rccm.201501-0188OCAuthor URL
Co-authorsMalcolm Starkey, Paul Foster, Philip Hansbro, Darryl Knight, Alan Hsu
2015Tolosa JM, Parsons KS, Hansbro PM, Smith R, Wark PA, 'The placental protein syncytin-1 impairs antiviral responses and exaggerates inflammatory responses to influenza.', PLoS One, 10 e0118629 (2015)
DOI10.1371/journal.pone.0118629Author URL
CitationsScopus - 1
Co-authorsRoger Smith, Philip Hansbro
2014Wark PAB, Murphy V, Mattes J, 'The interaction between mother and fetus and the development of allergic asthma', Expert Review of Respiratory Medicine, 8 57-66 (2014) [C1]

The rising prevalence of asthma and atopic disease in industrialized countries in the last 50 years has raised important questions about how and why the disease develops in susceptible populations. Most asthma begins in childhood in association with allergic sensitization and the development of a TH2 phenotype. It is recognized that asthma arises in the context of a complex interaction between genetic factors and the evolving immune system of the infant and the environment to which it is exposed, which now includes its in utero exposure. Early life exposures that lead to allergen sensitization and airway damage, especially in the form of viral respiratory tract infections, may lead to disease induction that commence the process that leads in some to asthma. Asthma models and early life observations suggest that repeated exposure to allergens and viral infection perpetuate a state of chronic airway inflammation leading to a maladaptive innate immune response that fails to resolve, characterized by chronic airway inflammation, airway remodeling and airway hyperresponsiveness. This article will concentrate on the development of asthma in the context of early life and maternal influences, including the effect of asthma on both the fetus and the mother. © 2014 Informa UK Ltd.

DOI10.1586/17476348.2014.848795
CitationsScopus - 3Web of Science - 3
Co-authorsVanessa Murphy, Joerg Mattes
2014Parsons KS, Hsu AC, Wark PAB, 'TLR3 and MDA5 signalling, although not expression, is impaired in asthmatic epithelial cells in response to rhinovirus infection', Clinical and Experimental Allergy, 44 91-101 (2014) [C1]

Summary: Background: Rhinoviruses (RV) are the most common acute triggers of asthma, and airway epithelial cells are the primary site of infection. Asthmatic bronchial epithelial cells (BECs) have been found to have impaired innate immune responses to RV. RV entry and replication is recognized by pathogen recognition receptors (PRRs), specifically toll-like receptor (TLR)3 and the RNA helicases; retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5). Objective: Our aim was to assess the relative importance of these PRRs in primary bronchial epithelial cells (pBEC) from healthy controls and asthmatics following RV infection and determine whether deficient innate immune responses in asthmatic pBECs were due to abnormal signalling via these PRRs. Methods: The expression patterns and roles of TLR3 and MDA5 were investigated using siRNA knock-down, with subsequent RV1B infection in pBECs from each patient group. We also used BX795, a specific inhibitor of TBK1 and IKKi. Results: Asthmatic pBECs had significantly reduced release of IL-6, CXCL-8 and IFN-¿ in response to RV1B infection compared with healthy pBECs. In healthy pBECs, siMDA5, siTLR3 and BX795 all reduced release of IL-6, CXCL-10 and IFN-¿ to infection. In contrast, in asthmatic pBECs where responses were already reduced, there was no further reduction in IL-6 and IFN-¿, although there was in CXCL-10. Conclusion and Clinical Relevance: Impaired antiviral responses in asthmatic pBECs are not due to deficient expression of PRRs; MDA5 and TLR3, but an inability to later activate types I and III interferon immune responses to RV infection, potentially increasing susceptibility to the effects of RV infection. © 2013 John Wiley & Sons Ltd.

DOI10.1111/cea.12218
CitationsScopus - 4Web of Science - 4
Co-authorsAlan Hsu
2014Djukanovic R, Harrison T, Johnston SL, Gabbay F, Wark P, Thomson NC, et al., 'The Effect of Inhaled IFN-beta on Worsening of Asthma Symptoms Caused by Viral Infections A Randomized Trial', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 190 145-154 (2014) [C1]
DOI10.1164/rccm.201312-2235OCAuthor URL
CitationsWeb of Science - 12
2013Murphy VE, Powell H, Wark PAB, Gibson PG, 'A Prospective Study of Respiratory Viral Infection in Pregnant Women With and Without Asthma', CHEST, 144 420-427 (2013) [C1]
DOI10.1378/chest.12-1956Author URL
CitationsScopus - 6Web of Science - 2
Co-authorsPeter Gibson, Vanessa Murphy
2013Hansbro P, Beckett E, Stevens R, Jarnicki A, Wark P, Foster P, 'A short-term model of COPD identifies a role for mast cell tryptase', EUROPEAN RESPIRATORY JOURNAL, 42 (2013)
Author URL
Co-authorsPaul Foster, Philip Hansbro
2013Vanders RL, Gibson PG, Murphy VE, Wark PAB, 'Plasmacytoid Dendritic Cells and CD8 T Cells From PregnantWomen Show Altered Phenotype and Function Following H1N1/09 Infection', JOURNAL OF INFECTIOUS DISEASES, 208 1062-1070 (2013) [C1]
DOI10.1093/infdis/jit296Author URL
CitationsScopus - 4Web of Science - 4
Co-authorsPeter Gibson, Vanessa Murphy
2013Beckett EL, Stevens RL, Jarnicki AG, Kim RY, Hanish I, Hansbro NG, et al., 'A new short-term mouse model of chronic obstructive pulmonary disease identifies a role for mast cell tryptase in pathogenesis', The Journal of Allergy and Clinical Immunology, 131 752-762 (2013) [C1]
CitationsScopus - 29Web of Science - 30
Co-authorsMing Yang, Philip Hansbro, Nicole Hansbro, Simon Keely, Paul Foster, Jay Horvat
2013Collison AM, Hatchwell LM, Verrills NM, Wark PA, Pereira De Siqueira AL, Tooze MK, et al., 'The E3 ubiquitin ligase midline 1 promotes allergen and rhinovirus-induced asthma by inhibiting protein phosphatase 2A activity', Nature Medicine, 19 232-237 (2013) [C1]
CitationsScopus - 32Web of Science - 27
Co-authorsPaul Foster, Nikki Verrills, Joerg Mattes
2013Vanders RL, Gibson PG, Wark PAB, Murphy VE, 'Alterations in inflammatory, antiviral and regulatory cytokine responses in peripheral blood mononuclear cells from pregnant women with asthma', RESPIROLOGY, 18 827-833 (2013) [C1]
DOI10.1111/resp.12068Author URL
CitationsScopus - 7Web of Science - 4
Co-authorsPeter Gibson, Vanessa Murphy
2013Wark PAB, Tooze M, Powell H, Parsons K, 'Viral and bacterial infection in acute asthma and chronic obstructive pulmonary disease increases the risk of readmission', RESPIROLOGY, 18 996-1002 (2013) [C1]
DOI10.1111/resp.12099Author URL
CitationsScopus - 11Web of Science - 9
2013Baines KJ, Hsu AC-Y, Tooze M, Gunawardhana LP, Gibson PG, Wark PAB, 'Novel immune genes associated with excessive inflammatory and antiviral responses to rhinovirus in COPD', RESPIRATORY RESEARCH, 14 (2013) [C1]
DOI10.1186/1465-9921-14-15Author URL
CitationsScopus - 7Web of Science - 8
Co-authorsAlan Hsu, Katherine Baines, Peter Gibson
2013Cheng AC, Holmes M, Irving LB, Brown SGA, Waterer GW, Korman TM, et al., 'Influenza Vaccine Effectiveness against Hospitalisation with Confirmed Influenza in the 2010-11 Seasons: A Test-negative Observational Study', PLOS ONE, 8 (2013) [C1]
DOI10.1371/journal.pone.0068760Author URL
CitationsScopus - 8Web of Science - 8
2012Sukkar MB, Ullah MA, Gan WJ, Wark PA, Chung KF, Hughes JM, et al., 'RAGE: a new frontier in chronic airways disease', British Journal of Pharmacology, 167 1161-1176 (2012) [C1]
CitationsScopus - 20Web of Science - 16
2012Hurt AC, Hardie K, Wilson NJ, Deng YM, Osbourn M, Leang SK, et al., 'Characteristics of a widespread community cluster of H275Y Oseltamivir-Resistant A (H1N1)pdm09 influenza in Australia', Journal of Infectious Diseases, 206 148-157 (2012) [C1]
CitationsScopus - 52Web of Science - 47
Co-authorsDavid Durrheim, Craig Dalton
2012Vanders RL, Wark PA, Murphy VE, Gibson PG, 'Pregnant women have attenuated innate interferon responses to 2009 pandemic influenza a virus subtype H1N1', Journal of Infectious Diseases, 206 646-653 (2012) [C1]
CitationsScopus - 13Web of Science - 12
Co-authorsVanessa Murphy, Peter Gibson
2012Bozinovski S, Uddin M, Vlahos R, Thompson M, McQualter JL, Merritt A-S, et al., 'Serum amyloid A opposes lipoxin A(4) to mediate glucocorticoid refractory lung inflammation in chronic obstructive pulmonary disease', Proceedings of the National Academy of Sciences of the United States of America, 109 935-940 (2012) [C1]
DOI10.1073/pnas.1109382109
CitationsScopus - 37Web of Science - 37
2012Vanders RL, Gibson PG, Murphy VE, Wark PAB, 'Impaired type I and III interferon response to rhinovirus infection during pregnancy and asthma', Thorax, 67 209-214 (2012) [C1]
CitationsScopus - 28Web of Science - 21
Co-authorsPeter Gibson, Vanessa Murphy
2012Sukkar MB, Wood LG, Tooze MK, Simpson JL, McDonald VM, Gibson PG, Wark PA, 'Soluble RAGE is deficient in neutrophilic asthma and COPD', European Respiratory Journal, 39 721-729 (2012) [C1]
Co-authorsJodie Simpson, Peter Gibson, Lisa Wood, Vanessa Mcdonald
2012Wark PA, Tooze M, Cheese L, Whitehead BF, Gibson PG, Wark K, McDonald VM, 'Viral infections trigger exacerbations of cystic fibrosis in adults and children', European Respiratory Journal, 40 510-512 (2012) [C1]
DOI10.1183/09031936.00202311
CitationsScopus - 6Web of Science - 7
Co-authorsVanessa Mcdonald, Peter Gibson
2012Ryan NM, Vertigan AE, Ferguson JK, Wark PA, Gibson PG, 'Clinical and physiological features of postinfectious chronic cough associated with H1N1 infection', Respiratory Medicine, 106 138-144 (2012) [C1]
DOI10.1016/j.rmed.2011.10.007
CitationsScopus - 4Web of Science - 4
Co-authorsNicole Ryan, Peter Gibson, John Ferguson
2012Wark PA, 'Airway inflammation in asthma, a single measurement is not enough', Respirology, 17 393-394 (2012) [C3]
CitationsScopus - 1Web of Science - 1
2012Hsu A, See HV, Hansbro PM, Wark PA, 'Innate immunity to influenza in chronic airways diseases', Respirology, 17 1166-1175 (2012) [C1]
CitationsScopus - 12Web of Science - 10
Co-authorsAlan Hsu, Philip Hansbro
2012Pretto JJ, McDonald VM, Wark PA, Hensley MJ, 'Multicentre audit of inpatient management of acute exacerbations of chronic obstructive pulmonary disease: Comparison with clinical guidelines', Internal Medicine Journal, 42 380-387 (2012) [C1]
DOI10.1111/j.1445-5994.2011.02475.x
CitationsScopus - 7Web of Science - 7
Co-authorsVanessa Mcdonald, Michael Hensley
2012Vlahos R, Wark PAB, Anderson GP, Bozinovski S, 'Glucocorticosteroids Differentially Regulate MMP-9 and Neutrophil Elastase in COPD', PLOS ONE, 7 (2012) [C1]
DOI10.1371/journal.pone.0033277Author URL
CitationsScopus - 20Web of Science - 16
2012Hsu A, Parsons KS, Barr I, Lowther S, Middleton D, Hansbro PM, Wark PA, 'Critical role of constitutive type I interferon response in bronchial epithelial cell to influenza infection', PLoS One, 7 e32947 (2012) [C1]
DOI10.1371/journal.pone.0032947
CitationsScopus - 18Web of Science - 20
Co-authorsPhilip Hansbro, Alan Hsu
2011Wark PA, 'Tiotropium reduced exacerbations more than salmeterol in moderate-to-very severe COPD', Annals of Internal Medicine, 155 3 (2011) [C3]
2011Cheng AC, Kotsimbos T, Kelly HA, Irving LB, Bowler SD, Brown SGA, et al., 'Effectiveness of H1N1/09 monovalent and trivalent influenza vaccines against hospitalization with laboratory-confirmed H1N1/09 influenza in Australia: A test-negative case control study', Vaccine, 29 7320-7325 (2011) [C1]
DOI10.1016/j.vaccine.2011.07.087
CitationsScopus - 26Web of Science - 24
2011Wood LG, Simpson JL, Wark PA, Powell H, Gibson PG, 'Characterization of innate immune signalling receptors in virus-induced acute asthma', Clinical and Experimental Allergy, 41 640-648 (2011) [C1]
DOI10.1111/j.1365-2222.2010.03669.x
CitationsScopus - 14Web of Science - 13
Co-authorsLisa Wood, Peter Gibson, Jodie Simpson
2011Katelaris CH, Linneberg A, Magnan A, Thomas WR, Wardlaw AJ, Wark PA, 'Developments in the field of allergy in 2010 through the eyes of Clinical and Experimental Allergy', Clinical and Experimental Allergy, 41 1690-1710 (2011) [C3]
DOI10.1111/j.1365-2222.2011.03892.x
CitationsScopus - 4Web of Science - 5
2011Hsu A, Barr I, Hansbro PM, Wark PA, 'Human influenza is more effective than Avian influenza at antiviral suppression in airway cells', American Journal of Respiratory Cell and Molecular Biology, 44 906-913 (2011) [C1]
DOI10.1165/rcmb.2010-0157OC
CitationsScopus - 12Web of Science - 9
Co-authorsPhilip Hansbro, Alan Hsu
2010Wood LG, Wark PA, Garg ML, 'Antioxidant and anti-inflammatory effects of resveratrol in airway disease', Antioxidants & Redox Signaling, 13 1535-1548 (2010) [C1]
DOI10.1089/ars.2009.3064
CitationsScopus - 39Web of Science - 40
Co-authorsLisa Wood, Manohar Garg
2010Wark PA, 'Viral and bacterial interactions in pneumonia', Expert Review of Respiratory Medicine, 4 221-228 (2010) [C1]
DOI10.1586/ers.10.5
CitationsScopus - 5
2010Reddel HK, Gibson PG, Peters MJ, Wark PA, Sand IB, Hoyos CM, Jenkins CR, 'Down-titration from high-dose combination therapy in asthma: Removal of long-acting b2-agonist', Respiratory Medicine, 104 1110-1120 (2010) [C1]
DOI10.1016/j.rmed.2010.04.003
CitationsScopus - 32Web of Science - 26
Co-authorsPeter Gibson
2010Osei-Kumah A, Wark PA, Smith R, Clifton VL, 'Asthma during pregnancy alters immune cell profile and airway epithelial chemokine release', Inflammation Research, 59 349-358 (2010) [C1]
DOI10.1007/s00011-009-0102-y
CitationsScopus - 6Web of Science - 5
Co-authorsVicki Clifton, Roger Smith
2009Wark PA, McDonald VM, 'Nebulised hypertonic saline for cystic fibrosis', Cochrane Database of Systematic Reviews, - CD001506 (2009) [C1]
DOI10.1002/14651858.cd001506.pub3
CitationsScopus - 61Web of Science - 35
Co-authorsVanessa Mcdonald
2009Saedi Some Olia A, Wood LG, Garg ML, Gibson PG, Wark PA, 'Anti-inflammatory effects of long-chain n-3 PUFA in rhinovirus-infected cultured airway epithelial cells', British Journal of Nutrition, 101 533-540 (2009) [C1]
DOI10.1017/s0007114508025798
CitationsScopus - 14Web of Science - 11
Co-authorsManohar Garg, Peter Gibson, Lisa Wood
2009Saedi Some Olia A, Wood LG, Garg ML, Gibson PG, Wark PA, 'Lycopene enrichment of cultured airway epithelial cells decreases the inflammation induced by rhinovirus infection and lipopolysaccharide', Journal of Nutritional Biochemistry, 20 577-585 (2009) [C1]
DOI10.1016/j.jnutbio.2008.06.001
CitationsScopus - 27Web of Science - 25
Co-authorsManohar Garg, Peter Gibson, Lisa Wood
2009Wark PA, Grissell TV, Davies BL, See HV, Gibson PG, 'Diversity in the bronchial epithelial cell response to infection with different rhinovirus strains', Respirology, 14 180-186 (2009) [C1]
DOI10.1111/j.1440-1843.2009.01480.x
CitationsScopus - 41Web of Science - 38
Co-authorsPeter Gibson
2008Saedi Some Olia A, Wood LG, Garg ML, Gibson PG, Wark PA, 'Supplementation of long chain N-3 polyunsaturated fatty acids increases the utilization of lycopene in cultured airway epithelial cells', Journal of Food Lipids, 15 421-432 (2008) [C1]
DOI10.1111/j.1745-4522.2008.00130.x
CitationsScopus - 5Web of Science - 3
Co-authorsLisa Wood, Manohar Garg, Peter Gibson
2008Wark PA, 'Guest editorial', Paediatric Respiratory Reviews, 9 233-235 (2008) [C3]
DOI10.1016/j.prrv.2008.05.006
2008See HV, Wark PA, 'Innate immune response to viral infection of the lungs', Paediatric Respiratory Reviews, 9 243-250 (2008) [C1]
DOI10.1016/j.prrv.2008.04.001
CitationsScopus - 29Web of Science - 26
2008Simpson JL, Wark PA, 'The role of exhaled nitric oxide and exhaled breath condensates in evaluating airway inflammation in asthma', Expert Opinion on Medical Diagnostics, 2 607-620 (2008) [C1]
DOI10.1517/17530059.2.6.607
CitationsScopus - 2
Co-authorsJodie Simpson
2008Oliver BGG, Lim S, Wark PA, Laza-Stanca V, King N, Black JL, et al., 'Rhinovirus exposure impairs immune responses to bacterial products in human alveolar macrophages', Thorax, 63 519-525 (2008) [C1]
DOI10.1136/thx.2007.081752
CitationsScopus - 54Web of Science - 47
2008Hansbro NG, Horvat JC, Wark PA, Hansbro PM, 'Understanding the mechanisms of viral induced asthma: New therapeutic directions', Pharmacology & Therapeutics, 117 313-353 (2008) [C1]
DOI10.1016/j.pharmthera.2007.11.002
CitationsScopus - 57Web of Science - 50
Co-authorsPhilip Hansbro, Nicole Hansbro, Jay Horvat
2007Weckmann M, Collison A, Simpson JL, Kopp MV, Wark PA, Smyth MJ, et al., 'Critical link between TRAIL and CCL20 for the activation of T(H)2 cells and the expression of allergic airway disease', Nature Medicine, 13 1308-1315 (2007) [C1]
DOI10.1038/nm1660
CitationsScopus - 61Web of Science - 59
Co-authorsJodie Simpson, Joerg Mattes, Peter Gibson, Paul Foster, Nicole Hansbro
2007Wark PA, Bucchieri F, Johnston SL, Gibson PG, Hamilton L, Mimica J, et al., 'IFN-gamma-induced protein 10 is a novel biomarker of rhinovirus-induced asthma exacerbations', Journal of Allergy and Clinical Immunology, 120 586-593 (2007) [C1]
DOI10.1016/j.jaci.2007.04.046
CitationsScopus - 82Web of Science - 78
Co-authorsJoanna Latter, Peter Gibson, John Attia
2006Wark PA, Gibson PG, 'Asthma exacerbations 3: Pathogenesis', Thorax, 61 909-915 (2006) [C1]
DOI10.1136/thx.2005.045187
CitationsScopus - 59Web of Science - 51
Co-authorsPeter Gibson
2006Wark PA, 'Safety concerns with salmeterool', Australian Prescriber, 29 118-119 (2006) [C3]
2006Contoli M, Message SD, Laza-Stanca V, Edwards MR, Wark PA, Bartlett N, et al., 'Role of eficient type III interferon-lambda production in asthma exacerbations', Nature Medicine, 12 1023-1026 (2006) [C1]
DOI10.1038/nm1462
CitationsScopus - 482Web of Science - 433
2005Wark PAB, McDonald V, Jones AP, 'Nebulised hypertonic saline for cystic fibrosis', COCHRANE DATABASE OF SYSTEMATIC REVIEWS, (2005)
DOI10.1002/14651858.CD001506.pub2Author URL
CitationsScopus - 7Web of Science - 1
Co-authorsVanessa Mcdonald
2005Wood LG, Garg ML, Simpson JL, Mori TA, Croft KD, Wark PA, Gibson PG, 'Induced sputum 8-isoprostane concentrations in inflammatory airway diseases', American Journal of Respiratory and Critical Care Medicine, 171 426-430 (2005) [C1]
DOI10.1164/rccm.200408-1010OC
CitationsScopus - 56Web of Science - 50
Co-authorsJodie Simpson, Lisa Wood, Peter Gibson, Manohar Garg
2005Wark PA, Johnston S, Bucchieri F, Powell R, Puddicombe S, Laza-Stanca V, et al., 'Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus', Journal of Experimental Medicine, 201 937-947 (2005) [C1]
DOI10.1084/jem.20041901
CitationsWeb of Science - 497
2004Wark PA, 'Pathogenesis of allergic bronchopulmonary aspergillosis and an evidence-based review of azoles in treatment', Respiratory Medicine, 98 915-923 (2004) [C1]
DOI10.1016/j.rmed.2004.07.002
2004Wark PA, 'Bronchitis (acute)', Clinical Evidence, 12 (2004) [C3]
2003Simpson JL, Moric I, Wark PA, Johnston S, Gibson PG, 'Use of induced sputum for the diagnosis of influenza and infections in asthma: a comparison of diagnostic techniques', Journal of Clinical Virology, 339-346 (2003) [C1]
DOI10.1016/S1386-6532(02)00084-7
CitationsScopus - 30Web of Science - 25
Co-authorsPeter Gibson, Jodie Simpson
2003Wark PA, Hensley MJ, Saltos N, Boyle MJ, Toneguzzi R, Simpson JL, et al., 'Anti-inflammatory effect of itraconazole in stable allergic bronchopulmonary aspergillosis: A randomized controlled trial', The Journal of Allergy and Clinical Immunology, 111 952-957 (2003) [C1]
DOI10.1067/mai.2003.1388
CitationsScopus - 144Web of Science - 111
Co-authorsJodie Simpson, Peter Gibson, Michael Hensley
2003Gibson PG, Wark PA, Simpson JL, Meldrum CJ, Meldrum S, Saltos N, Boyle MJ, 'Induced sputum IL-8 gene expression, neutrophil influx and MMP-9 in allergic bronchopulmonary aspergillosis', European Respiratory Journal, 21 582-588 (2003) [C1]
DOI10.1183/09031936.03.00001803
CitationsScopus - 37Web of Science - 28
Co-authorsPeter Gibson, Jodie Simpson
2002Wark PA, Johnston S, Simpson JL, Hensley MJ, Gibson PG, 'Chlamydia pneumoniae immunoglobulin A reactivation and airway inflammation in acute asthma', The European Respiratory Journal, 20 834-840 (2002) [C1]
CitationsScopus - 50Web of Science - 42
Co-authorsPeter Gibson, Michael Hensley, Jodie Simpson
2002Wark PA, Johnston S, Moric I, Simpson JL, Hensley MJ, Gibson PG, 'Neutrophil degranulation and cell lysis is associated with clinical severity in virus-induced asthma', The European Respiratory Journal, 19 68-75 (2002) [C1]
CitationsScopus - 203Web of Science - 179
Co-authorsPeter Gibson, Michael Hensley, Jodie Simpson
2002Wark PA, Simpson JL, Hensley MJ, Gibson PG, 'Airway inflammation in thunderstorm asthma', Clinical and Experimental Allergy, 32 1750-1756 (2002) [C1]
CitationsScopus - 27Web of Science - 21
Co-authorsPeter Gibson, Michael Hensley, Jodie Simpson
2002Simpson JL, Gibson PG, Wark PA, 'Optimization of sputum-processing methods for the measurement of interleukin-5: Effects of protease inhibition', Respirology, 7 111-116 (2002) [C1]
CitationsScopus - 8Web of Science - 10
Co-authorsPeter Gibson, Jodie Simpson
2001Wark PA, Simpson J, Hensley MJ, Gibson PG, 'Safety of sputum induction with isotonic saline in adults with acute severe asthma', Clinical and Experimental Allergy, 31 1745-1753 (2001) [C1]
CitationsScopus - 27Web of Science - 23
Co-authorsPeter Gibson, Jodie Simpson, Michael Hensley
2001Gibson PG, Simpson J, Chalmers AC, Toneguzzi R, Wark PA, Wilson AJ, Hensley MJ, 'Airway Eosinophilia is associated with Wheeze but is uncommon in Children with Persistent Cough and Frequent Chest Colds', American Journal of Respiratory and Critical Care Medicine, 164 977-981 (2001) [C1]
CitationsScopus - 43Web of Science - 35
Co-authorsJodie Simpson, Anita Chalmers, Peter Gibson, Michael Hensley, Amanda Wilson
2001Wark PA, Gibson PG, Johnston S, 'Exacerbations of asthma: addressing the triggers and treatments', Monaldi Archives for Chest Disease, 56 429-435 (2001) [C1]
Co-authorsPeter Gibson
2001Wark PA, Gibson PG, 'Allergic bronchopulmonary aspergillosis: New concepts of pathogenesis and treatment', Respirology, 6 1-7 (2001) [C2]
CitationsScopus - 49
Co-authorsPeter Gibson
2000Wark PA, Saltos N, Simpson J, Slater S, Hensley MJ, Gibson PG, 'Induced sputum easinophils and neutrophils and bronchiectasis severity in allergic bronchopulmonary aspergillosis', European Respiratory Journal, 16 1095-1101 (2000) [C1]
CitationsScopus - 51Web of Science - 39
Co-authorsMichael Hensley, Peter Gibson, Jodie Simpson
2000Wark PA, Gibson PG, Fakes K, 'Induced sputum eosinophils in the assessment of asthma and chronic cough*', Respirology, 5 51-57 (2000) [C1]
CitationsScopus - 17
Co-authorsPeter Gibson
2000Wark PA, Wilson A, Gibson PG, 'Azoles for allergic bronchopulmonary aspergillosis', The Cochrane Library, 1-9 (2000) [C1]
Co-authorsPeter Gibson
1999Wark PAB, Fakes K, Gibson PG, 'Induced sputum eosinophils in the assessment of asthma and chronic cough.', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 159 A850-A850 (1999)
Author URL
Show 70 more journal articles

Review (1 outputs)

YearCitationAltmetricsLink
2004Wark PA, Gibson PG, Wilson AJ, 'Azoles for Allergic Bronchopulmonary Aspergillosis Associated With Asthma', Cochrane Database of Systematic Reviews (2004) [D1]
DOI10.1002/14651858.CD001108
CitationsScopus - 1
Co-authorsPeter Gibson, Amanda Wilson

Conference (82 outputs)

YearCitationAltmetricsLink
2014Hsu A, Parsons K, Fujita T, Hansbro P, Wark P, 'Critical role of PKR in antiviral stress granule and IFN-beta enhanceosome formation, and is impaired in chronic obstructive pulmonary disease', CYTOKINE, Melbourne, AUSTRALIA (2014) [E3]
DOI10.1016/j.cyto.2014.07.088Author URL
Co-authorsPhilip Hansbro, Alan Hsu
2014Hsu A, Parsons K, Hansbro P, Wark P, 'Enhanced PI3K activity leads to decreased IFN-beta response to influenza infection in chronic obstructive pulmonary disease', CYTOKINE, Melbourne, AUSTRALIA (2014) [E3]
DOI10.1016/j.cyto.2014.07.089Author URL
Co-authorsPhilip Hansbro, Alan Hsu
2014Starkey M, Hanish I, Dua K, Nair P, Haw T, Hsu A, et al., 'Interleukin-13 predisposes mice to more severe influenza infection by suppressing interferon responses and activating microRNA-21/PI3K', CYTOKINE, Melbourne, AUSTRALIA (2014) [E3]
DOI10.1016/j.cyto2014.07.182Author URL
Co-authorsJay Horvat, Paul Foster, Alan Hsu, Darryl Knight, Philip Hansbro, Malcolm Starkey
2014Fathi F, Hsu A, Parsons K, Keely S, Wood L, Wark P, 'OXIDATIVE STRESS IMPAIRS MITOCHONDRIAL FUNCTION AND LEADS TO DEFICIENT ANTIVIRAL RESPONSES IN PRIMARY BRONCHIAL EPITHELIAL CELLS', RESPIROLOGY (2014) [E3]
DOI10.1111/resp.12263_3Author URL
Co-authorsAlan Hsu, Simon Keely, Lisa Wood
2014Collison A, Hatchwell L, Girkin J, Li J, Parsons K, Bartlett N, et al., 'REDUCED TLR7 EXPRESSION MAY UNDERPIN IMPAIRED RESPONSE TO VIRAL INFECTION IN ASTHMA', RESPIROLOGY (2014) [E3]
DOI10.1111/resp.12263_5Author URL
Co-authorsJoerg Mattes, Paul Foster
2014Hsu A, Parsons K, Hansbro P, Wark P, Wark P, 'IMPAIRED FORMATION OF ANTIVIRAL STRESS GRANULE AND INTERFERON-BETA ENHANCEOSOME LEADS TO REDUCED ANTIVIRAL RESPONSES TO INFLUENZA IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE', RESPIROLOGY (2014) [E3]
Author URL
Co-authorsPhilip Hansbro, Alan Hsu
2014Wark PPW, Tolosa JMJT, Parsons K, Smith R, 'The placental derived protein syncytin-1 impairs antiviral responses and exaggerates inflammatory responses to influenza', Cytokine, Melbourne, Vic (2014) [E3]
DOI10.1016/j.cyto.2014.07.154Author URL
Co-authorsRoger Smith
2014Tolosa JM, Parsons K, Wark P, Smith R, 'HOW THE PLACENTA MAKES PREGNANT WOMEN VULNERABLE TO INFLUENZA (FLU)', PLACENTA, Paris, FRANCE (2014) [E3]
Author URL
Co-authorsRoger Smith
2013Hansbro P, Beckett E, Stevens R, Jarnicki A, Kim R, Hanish I, et al., 'A short-term model of COPD identifies a role for mast cell tryptase', JOURNAL OF IMMUNOLOGY, Honolulu, HI (2013) [E3]
Author URL
Co-authorsPhilip Hansbro, Nicole Hansbro, Simon Keely, Paul Foster, Ming Yang, Jay Horvat
2013Forbes RL, Gibson PG, Murphy VE, Wark PA, 'H1N1PDM09 ALTERS MATERNAL IMMUNITY DURING PREGNANCY', RESPIROLOGY (2013) [E3]
Author URL
Co-authorsPeter Gibson, Vanessa Murphy
2013Zhong H, Simpson JL, Wood LG, Wark PAB, 'COPD PERIPHERAL BLOOD NEUTROPHILS HAVE ENHANCED RELEASE OF IL-1B WHEN STIMULATED', RESPIROLOGY (2013) [E3]
Author URL
Co-authorsLisa Wood, Jodie Simpson
2012Patel S, McKay K, Cooper P, Sorrell T, Andresen D, Middleton P, et al., 'Fungal colonisation and clinical associations in children with cystic fibrosis', Mycoses, Berlin, Germany (2012) [E3]
2012Addnan FH, Wood LG, Garg ML, Wark PA, 'Antiviral effects of antioxidants on human rhinovirus', Respirology, Canberra, ACT (2012) [E3]
Co-authorsManohar Garg, Lisa Wood
2012Hsu A, Parsons KS, Barr I, Hansbro PM, Wark PA, 'Deficient antiviral responses to influenza in primary bronchial epithelial cells of chronic obstructive pulmonary disease', Respirology, Canberra, ACT (2012) [E3]
Co-authorsAlan Hsu, Philip Hansbro
2012McDonald VM, Wark PA, Roberts M, Spencer LM, Alison JA, Wood LG, Gibson PG, 'Development and audience testing of a COPD education DVD', Respirology, Canberra, ACT (2012) [E3]
Co-authorsPeter Gibson, Vanessa Mcdonald, Lisa Wood
2012Zhong H, Simpson JL, Wood LG, Wark PA, 'Activation of human neutrophils exposed to cigarette smoke extract: A comparison of COPD patients versus healthy non-smokers', Respirology, Canberra, ACT (2012) [E3]
Co-authorsJodie Simpson, Lisa Wood
2012Parsons KS, Tooze MK, Grissell TV, Bell N, Chapman JN, Ryan J, et al., 'Patterns (2007-2009) of respiratory viruses isolated from acute exacerbations of airways disease', Respirology, Canberra, ACT (2012) [E3]
Co-authorsPeter Gibson
2012See HV, Simpson JL, Hansbro PM, Wark PA, 'Stable COPD patients have less rhinovirus-induced intracellular innate cytokines detected in PBMCS compared to healthy adults', Respirology, Canberra, ACT (2012) [E3]
Co-authorsJodie Simpson, Philip Hansbro
2012Wark PA, Tooze MK, Cheese L, Whitehead BF, Gibson PG, McDonald VM, 'Viral infections trigger CF exacerbations and worsen infection with P Aeruginosa in adults and children', Respirology, Canberra, ACT (2012) [E3]
Co-authorsVanessa Mcdonald, Peter Gibson
2012Wark PA, Tooze MK, Hsu A, Parsons KS, 'Silencing of MDA5 and TLR3 does not reduce innate immune responses to rhinovirus in defective asthmatic bronchial epithelial cells', Respirology, Canberra, ACT (2012) [E3]
Co-authorsAlan Hsu
2012Zhong H, Simpson JL, Wood LG, Wark PA, 'Different responses of blood neutrophils from COPD', Respirology, Hong Kong (2012) [E3]
Co-authorsJodie Simpson, Lisa Wood
2011Addnan FH, Wark PA, Wood LG, Garg ML, 'Antiviral activity of antioxidants against rhinovirus infection', Australasian Medical Journal, Queenstown, NZ (2011) [E3]
Co-authorsManohar Garg, Lisa Wood
2011Addnan FH, Wark PA, Wood LG, Garg ML, 'Effects of antioxidants on inflammation and apoptosis in rhinovirus-infected airway epithelial cells', Australasian Medical Journal, Queenstown, NZ (2011) [E3]
Co-authorsManohar Garg, Lisa Wood
2011Smart JM, Wark PA, Wood LG, 'Investigating the obesity paradox in ex-smokers', Australasian Medical Journal, Queenstown, NZ (2011) [E3]
Co-authorsLisa Wood
2011Bozinovski S, Uddin M, Vlahos R, Thompson M, Merritt A-S, Wark PA, et al., 'Serum amyloid A augments mucosal immunity by opposing resolving Lipoxina4 signaling in chronic lung disease', American Journal of Respiratory and Critical Care Medicine, Denver, CO (2011) [E3]
2011Sukkar MB, Wood LG, Tooze MK, Simpson JL, McDonald VM, Gibson PG, Wark PA, 'Deficiency of srage in asthma and COPD is selectively associated with neutrophilic airway inflammation', American Journal of Respiratory and Critical Care Medicine, Denver, CO (2011) [E3]
Co-authorsLisa Wood, Peter Gibson, Vanessa Mcdonald, Jodie Simpson
2011Sukkar M, Wood LG, Tooze MK, Simpson JL, McDonald VM, Gibson PG, Wark PA, 'Soluble RAGE is deficient in neutrophilic asthma and COPD', Respirology, Perth, WA (2011) [E3]
DOI10.1183/09031936.00022011
CitationsScopus - 45Web of Science - 39
Co-authorsLisa Wood, Peter Gibson, Jodie Simpson, Vanessa Mcdonald
2011Baines KJ, Tooze MK, Wark PA, 'Rhinovirus infected airway epithelial cells have an increased pro-inflammatory response in COPD', Respirology, Perth, WA (2011) [E3]
Co-authorsKatherine Baines
2011Vanders RL, Gibson PG, Murphy VE, Wark PA, 'Reduced antiviral interferons during pregnancy explains susceptibility to influenza virus infection', Respirology, Perth, WA (2011) [E3]
Co-authorsVanessa Murphy, Peter Gibson
2011Parsons KS, Tooze MK, Hsu A, Wark PA, 'Oxidative stress induces mitochondrial dusfunction in airway epithelial cells and impairs response to rhinovirus', Respirology, Perth, WA (2011) [E3]
Co-authorsAlan Hsu
2011Ryan NM, Vertigan AE, Ferguson JK, Wark PA, Gibson PG, 'Investigation and characterization of persistent cough associated with H1N1 2009 influenza', Respirology, Perth, WA (2011) [E3]
Co-authorsPeter Gibson, John Ferguson, Nicole Ryan
2011See HV, Simpson JL, Hansbro PM, Wark PA, 'COPD patients PBMCS have an impaired immune response to phinovirus-infected bronchial epithelium', Respirology, Perth, WA (2011) [E3]
Co-authorsJodie Simpson, Philip Hansbro
2011Wark PA, Parsons KS, Tooze MK, Hsu A, 'MDA5 is crucial inhibiting rhinovirus replication in primary bronchial epithelial cells', Respirology, Perth, WA (2011) [E3]
Co-authorsAlan Hsu
2011Zhong H, Tooze MK, Wood LG, Simpson JL, Wark PA, 'Effect of cigarette smoke extract on neutrophils isolated from human peripheral blood', Respirology, Perth, WA (2011) [E3]
Co-authorsLisa Wood, Jodie Simpson
2011Hatchwell LM, Collison AM, Pereira De Siqueira AL, Foster PS, Verrills NM, Don A, et al., 'A novel E3 ubiquitin ligase links rhinovirus infection to exacerbation of asthma', Respirology, Perth, WA (2011) [E3]
Co-authorsPaul Foster, Nikki Verrills, Joerg Mattes
2010Smart JM, Wark PA, McDonald VM, Wood LG, 'Body composition in ex-smokers with and without airflow obstruction', Obesity Research and Clinical Practice, Sydney, NSW (2010) [E3]
Co-authorsVanessa Mcdonald, Lisa Wood
2010Smart JM, Wark PA, McDonald VM, Wood LG, 'Low levels of body fat and obstructive airway disease in ex-smokers', Proceedings of the Nutrition Society of Australia, Perth (2010) [E3]
Co-authorsVanessa Mcdonald, Lisa Wood
2010Pretto JJ, McDonald VM, Wark PA, Hensley MJ, 'An audit of clinical practice for COPD hospital admissions to eight Australian public hospitals', European Respiratory Society Annual Congress 2010. Abstracts, Barcelona, Spain (2010) [E3]
Co-authorsVanessa Mcdonald, Michael Hensley
2010Vanders RL, Gibson PG, Murphy VE, Wark PA, 'Reduced anti-viral responses: Why pregnant women have increased susceptibility to respiratory virus infection', American Journal of Respiratory and Critical Care Medicine, New Orleans, LO (2010) [E3]
Co-authorsPeter Gibson, Vanessa Murphy
2010Vanders RL, Gibson PG, Murphy VE, Wark PA, 'Reduced anti-viral responses: Why pregnant women have increased susceptiblty to respiratory virus infection', Respirology, Brisbane, QLD (2010) [E3]
Co-authorsVanessa Murphy, Peter Gibson
2010Gangireddy SR, Parsons KS, Tooze MK, Wark PA, 'The innate immune response to rhinovirus in bronchial epithelial cells is predominately controlled by signalling initiated via MDA-5', Respirology, Brisbane, QLD (2010) [E3]
2010McDonald VM, Pretto JJ, Wark PA, Hensley MJ, 'Low acuity COPD admissions: Are they avoidable?', Respirology, Brisbane, QLD (2010) [E3]
Co-authorsVanessa Mcdonald, Michael Hensley
2010Parsons KS, Tooze MK, Gangireddy SR, Wark PA, 'Cigarette smoke extract impairs epithelial cell antiviral response to rhinovirus infection', Respirology, Brisbane, QLD (2010) [E3]
2010Pretto JJ, McDonald VM, Wark PA, Hensley MJ, 'An audit of clinical practice for COPD hospital admissions', Respirology, Brisbane, QLD (2010) [E3]
Co-authorsMichael Hensley, Vanessa Mcdonald
2010Smart JM, Wark PA, McDonald VM, Wood LG, 'CRP, body composition and lung function in ex-smokers', Respirology, Brisbane, QLD (2010) [E3]
Co-authorsVanessa Mcdonald, Lisa Wood
2010Yan X, He S, Gangireddy SR, Gibson PG, Wark PA, 'Monocyte derived dendritic cells from COPD patients and their therapeutic potential', Respirology, Brisbane, QLD (2010) [E3]
Co-authorsPeter Gibson
2009Southern KW, Smyth A, Wark PA, Ryan G, Dwan K, Yates N, et al., 'The impact of Cochrane systematic reviews on cyctic fibrosis care', Pediatric Pulmonology, Minneapolis (2009) [E3]
DOI10.1002/ppul.21133
2009Wark PA, Hsu A, Hansbro PM, 'Innate immune response of bronchial epithelial cells to infection with influenza', Journal of Immunology, Seattle, WASH. (2009) [E3]
Co-authorsPhilip Hansbro, Alan Hsu
2009Wark PA, See HV, Simpson JL, Vanders RL, Hansbro PM, 'Peripheral blood monocytes (PBMCs) display innate antiviral response to rhinovirus (RV) infected bronchial epithelial cells', Journal of Immunology, Seattle, WASH. (2009) [E3]
Co-authorsPhilip Hansbro, Jodie Simpson
2009Addnan FH, Wood LG, Garg ML, Wark PA, 'Resveratrol prevents hydrogen peroxide induced cytotoxicity', Proceedings of the Nutrition Society of Australia, Newcastle, NSW (2009) [E3]
Co-authorsLisa Wood, Manohar Garg
2009Foo A, Lam CE, Wark PA, Foster PS, Phipps S, 'Immune mechanisms that promote the development of inducible bronchus-associated lymphoid tissue (iBALT)', American Journal of Respiratory and Critical Care Medicine, San Diego, CA (2009) [E3]
Co-authorsPaul Foster
2009Parsons KS, Gangireddy SR, Hansbro PM, Barr I, Wark PA, 'Response of primary bronchial epithelial cells to infection with human influenza virus', Respirology, Darwin, NT (2009) [E3]
DOI10.1111/j.1440-1843.2009.01502_7.x
Co-authorsPhilip Hansbro
2009Wark PA, Parsons KS, Ryan J, Grissell T, Bell N, Chapman JN, Gibson PG, 'Seasonal patterns (2004-2007) of respiratory viruses isolated with acute airways disease', Respirology, Darwin, NT (2009) [E3]
DOI10.1111/j.1440-1843.2009.01503_1.x
Co-authorsPeter Gibson
2009Twaddell S, Loewenthal MR, Gibson PG, Saltos N, Wark PA, 'Individualised aminoglycoside dosing in adult patients with cystic fibrosis improves pharmacokinetic parameters', Respirology, Darwin, NT (2009) [E3]
DOI10.1111/j.1440-1843.2009.01503_1.x
Co-authorsPeter Gibson
2009Baines KJ, Grissell TV, Gibson PG, Wark PA, 'Molecular mechanisms of rhinovirus infection of primary bronchial epithelial cells', Respirology, Darwin, NT (2009) [E3]
DOI10.1111/j.1440-1843.2009.01503_1.x
Co-authorsKatherine Baines, Peter Gibson
2009Clarke J, Cookson K, Gendle L, Bentley L, Wark PA, McDonald VM, 'Evaluation of patient acceptance of CF segregation and isolation policies', Respirology, Darwin, NT (2009) [E3]
DOI10.1111/j.1440-1843.2009.01502_7.x
Co-authorsVanessa Mcdonald
2009Wark PA, Oldham RA, Brooks C, Simpson JL, Douwes J, 'Airway neutrophilia in chronic obstructive pulmonary disease (COPD) and asthma are associated with lower lung function and the presence of pathogenic bacteria', Respirology, Darwin, NT (2009) [E3]
DOI10.1111/j.1440-1843.2009.01502_7.x
Co-authorsJodie Simpson
2009Hsu A, Hansbro PM, Barr I, Wark PA, 'Innate immune response of bronchial epithelial cells to human and avian influenza virus', Respirology, Darwin, NT (2009) [E3]
Co-authorsPhilip Hansbro, Alan Hsu
2008Oliver BGG, Kuo C, Johnston SL, King NJC, Wark PA, Lim S, et al., 'Rhinovirus infection of primary human airway smooth muscle cells and fibroblasts induces extracellular matrix deposition', American Journal of Respiratory and Critical Care Medicine, Toronto, ONT (2008) [E3]
2008Wark PA, Davies BL, Parsons KS, Grissell T, 'Impaired release of inflammatory mediators from COPD bronchial epithelial cells (BECs) in response to rhinovirus (RV) and lipopolysaccharide (LPS)', Respirology, Melbourne, VIC (2008) [E3]
DOI10.1111/j.1440-1843.2008.01252.x
2008Wark PA, Oldham RA, Simpson JL, Douwes J, 'Endotoxin levels are higher in the bronchoalveolar lavage of ex-smokers compared to never smokers', Respirology, Melbourne, VIC (2008) [E3]
DOI10.1111/j.1440-1843.2008.01252.x
Co-authorsJodie Simpson
2008Hsu A, Grissell TV, Wark PA, 'Distribution of SAa2,6GAL and SAa2,3GAL linked receptors in human respiratory tract and influenza virus replication', Respirology, Melbourne, VIC (2008) [E3]
DOI10.1111/j.1440-1843.2008.01252_13.x
Co-authorsAlan Hsu
2008Osei-Kumah A, Wark PA, Smith R, Ammit A, Clifton VL, 'A model of pregnancy induced changes in asthma', 51st Annual Scientific Meeting of the Endocrine Society of Australia and Society of Reproductive Biology: Meeting Proceedings and Abstract Book, Melbourne, VIC (2008) [E3]
Co-authorsVicki Clifton, Roger Smith
2008Hsu A, Hansbro PM, Wark PA, 'Innate immune response of bronchial epithelial cells to human and avian influenza virus', The 4th Congress of the Federation of Immunology Societies of Asia-Oceania: Conference Program, Taipei, Taiwan (2008) [E3]
Co-authorsPhilip Hansbro, Alan Hsu
2007Grissell TV, Hansbro NG, Hsu A, Mimica J, Wark PA, 'Response of primary bronchoepithelial cells from COPD, asthmatic and healthy subjects to infection with avian and human influenza virus strains', Respirology (Abstracts of the 12th Congress of the Asian Pacific Society of Respirology), Gold Coast, QLD (2007) [E3]
Co-authorsNicole Hansbro
2007De Groot RS, Kuo C, King N, Moir L, Lim S, Burgess JK, et al., 'Steroids can reverse rhinovirus-induced alterations to bronchial epithhelium extracellular matrix deposition', Respirology (Abstracts of the 12th Congress of the Asian Pacific Society of Respirology), Gold Coast, QLD (2007) [E3]
2007Reddel HK, Peters MJ, Wark PA, Sand IB, Jenkins CR, 'Comparison of the efficacy of seretide and flixotide when down-titrating the inhaled corticosteroid dose', American Journal of Respiratory and Critical Care Medicine (American Thoracic Society 2007 International Conference Abstracts), San Francisco (2007) [E3]
2007Xatzipsalti M, Haynes R, Ribbene A, Sones JL, Bagmane D, Wark PA, et al., 'Deficient interferon production following rhinovirus infection of differentiated bronchial epithelial cells from asthmatic subjects', American Journal of Respiratory and Critical Care Medicine (American Thoracic Society 2007 International Conference Abstracts), San Francisco (2007) [E3]
2007Wark PA, See HV, Oldham R, Timmins N, Gibson PG, Hansbro PM, 'Response by peripheral blood monocytes (PBMCs) to rhinovirus (RV) is greater in cells exposed to infected epithelium in coculture than exposed to RV alone', American Journal of Respiratory and Critical Care Medicine (American Thoracic Society 2007 International Conference Abstracts), San Francisco (2007) [E3]
Co-authorsPhilip Hansbro, Peter Gibson
2007Wark PA, Grissell TV, Davies B, Mimica J, Oldham R, Shafren DR, Gibson PG, 'Bronchial epithelial cell (BEC) response to clinical rhinovirus (clin-RV) isolates from ASTHMATICS compared to laboratory (lab-RV) strains', American Journal of Respiratory and Critical Care Medicine (American Thoracic Society 2007 International Conference Abstracts), San Francisco (2007) [E3]
Co-authorsPeter Gibson
2007Ribbene A, Bucchieri F, Wark PA, Andrews AL, Puddicombe SM, Zummo G, et al., 'Epithelial-mesenchymal communication following rhinovirus infection of asthmatic bronchial epithelial cells', American Journal of Respiratory and Critical Care Medicine (American Thoracic Society 2007 International Conference Abstracts), San Francisco (2007) [E3]
2007Saedi Some Olia A, Garg ML, Wood LG, Wark PA, Gibson PG, 'Lycopene enrichment of cultured epithelial airway cells', Asia Pacific Journal of Clinical Nutrition, Auckland, New Zealand (2007) [E3]
Co-authorsLisa Wood, Peter Gibson, Manohar Garg
2007Saedi Some Olia A, Garg ML, Wood LG, Gibson PG, Wark PA, 'Anti-inflammatory effect of lycopene enrichment on infected cultured airway epithelial cells', Respirology (Abstracts of the 12th Congress of the Asian Pacific Society of Respirology), Gold Coast, QLD (2007) [E3]
Co-authorsManohar Garg, Peter Gibson, Lisa Wood
2007See H, Oldham R, Timmins N, Hansbro PM, Wark PA, Gibson PG, 'Rhinovirus (RV) induced inflammatory response in mononuclear cells is enhanced by coculture with airway epithelium', Respirology (TSANZ Abstracts-Posters), Auckland (2007) [E3]
DOI10.1111/j.1440-1843.2007.001050.x
Co-authorsPeter Gibson, Philip Hansbro
2007Wark PA, Mimica J, Oldham R, Davies DE, Holgate SE, Johnston S, Gibson PG, 'Interferon-G induced protein (IP)- 10 is a novel clinical biomarker of rhinovirus (RV)-induced asthma exacerbations', Respirology (TSANZ Abstracts-Posters), Auckland (2007) [E3]
Co-authorsPeter Gibson
2007Jenkins CR, Marks GB, Gibson PG, Wark PA, Thien FCK, Belousova EG, et al., 'A randomised controlled trial of two algorithms for maintaining asthma control on long acting bronchodilators (LABA) and inhaled corticosteroids (ICS)', Respirology (TSANZ Abstracts-Posters), Auckland (2007) [E3]
Co-authorsPeter Gibson
2006Grissell TV, Davies B, Mimica JL, Shafren DR, Gibson PG, Wark PA, 'Bronchial epithelial cell response to clinical rhinoviruses isolated from asthmatics compared to laboratory rhinovirus strains', Respirology, Canberra (2006) [E3]
Co-authorsPeter Gibson
2006Wark PA, Wood LG, Grissell TV, Davies B, Shafren DR, Powell HG, et al., 'Acute virus-induced asthma is characterised by increased expression of toll-like receptors (TLR)-2', Respirology, Canberra (2006) [E3]
Co-authorsLisa Wood, Michael Hensley, Peter Gibson
2004Wark PAB, Johnston SL, Bucchieri F, Powell R, Puddicombe S, Laza-Stanca V, et al., 'Asthmatic bronchial epithelial cells have deficient innate immune response to infection with rhinovirus', THORAX, London, ENGLAND (2004)
Author URL
2003Wark PAB, Buccheri F, Puddicombe S, Johnston SJ, Holgate ST, Davies DE, 'Asthmatic bronchial epithelial cells (BEC) are more resistant to early apoptosis induced by rhinovirus (RV) and this is associated with increased viral replication', THORAX, LONDON, ENGLAND (2003)
Author URL
2003Wark PAB, Bucchieri F, Puddicombe SM, Andrews AL, Johnston SL, Davies DE, Holgate ST, 'Cytotoxic effects of infection with rhinovirus on asthmatic primary bronchial epithelial cells', EUROPEAN RESPIRATORY JOURNAL, TAORMINA, ITALY (2003)
Author URL
2002Wark PAB, Puddicombe SM, Frew AJ, Holgate ST, Davies DE, 'Determinants of cytotoxicity of residual oil fly ash (ROFA) on bronchial epithelial cells', THORAX, LONDON, ENGLAND (2002)
Author URL
Show 79 more conferences

Creative Work (1 outputs)

YearCitationAltmetricsLink
2011McDonald VM, Wark PA, Gibson PG, Alison J, Spencer L, Wood LG, Roberts M, Living with COPD: Chronic Obstructive Pulmonary Disease, The Australian Lung Foundation, Newcastle (2011) [J2]
Co-authorsPeter Gibson, Lisa Wood, Vanessa Mcdonald
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Grants and Funding

Summary

Number of grants46
Total funding$11,919,759

Click on a grant title below to expand the full details for that specific grant.


20152 grants / $1,101,476

Modifying epigenetics as a novel treatment in COPD$1,076,254

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Phil Hansbro, Professor Darryl Knight, Conjoint Professor Peter Wark, Professor Ian Adcock
SchemeProject Grant
RoleInvestigator
Funding Start2015
Funding Finish2015
GNoG1400006
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Enhanced oxidative stress impairs mitochondrial function and antiviral responses to rhinovirus infection in asthma and chronic obstructive pulmonary disease$25,222

Funding body: John Hunter Hospital Charitable Trust Fund

Funding bodyJohn Hunter Hospital Charitable Trust Fund
Project TeamDoctor Alan Hsu, Conjoint Professor Peter Wark, Miss Kristy Parsons
SchemeResearch Grant
RoleInvestigator
Funding Start2015
Funding Finish2015
GNoG1500012
Type Of FundingOther Public Sector - State
Category2OPS
UONY

20145 grants / $3,283,535

National Clinical Centre of Research Excellence in Severe Asthma$2,542,311

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamConjoint Professor Peter Gibson, Professor Guy Marks, Associate Professor Vanessa McDonald, Conjoint Professor Peter Wark, Conjoint Associate Professor Greg King, Dr Bruce Thompson, Associate Professor Helen Reddel, Professor John Upham, Dr Lorraine Smith, Professor Alan James
SchemeCentres of Research Excellence (CRE) - Centres of Clinical Research Excellence
RoleInvestigator
Funding Start2014
Funding Finish2014
GNoG1400017
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Toll-like receptor 7 and asthma $673,712

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Joerg Mattes, Laureate Professor Paul Foster, Conjoint Professor Peter Wark
SchemeProject Grant
RoleInvestigator
Funding Start2014
Funding Finish2014
GNoG1300093
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Mechanisms of dysregulated antiviral signallings to influenza infection in chronic obstructive pulmonary disease$27,512

Funding body: John Hunter Hospital Charitable Trust Fund

Funding bodyJohn Hunter Hospital Charitable Trust Fund
Project TeamDoctor Alan Hsu, Doctor Fatemeh Moheimani, Professor Darryl Knight, Conjoint Professor Peter Wark
SchemeResearch Grant
RoleInvestigator
Funding Start2014
Funding Finish2014
GNoG1400435
Type Of FundingOther Public Sector - State
Category2OPS
UONY

Immunosenescence in chronic obstructive pulmonary disease leads to abnormal innate immune responses to human rhinovirus infection$20,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamConjoint Professor Peter Wark, Professor Darryl Knight
SchemeProject Grant
RoleLead
Funding Start2014
Funding Finish2014
GNoG1301331
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

Predicting who is at risk of worsening lung disease in Cystic Fibrosis$20,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamConjoint Professor Peter Wark, Doctor Katie Baines, Associate Professor Vanessa McDonald, Conjoint Professor Peter Gibson, Associate Professor Scott Bell, Dr David Reid
SchemeProject Grant
RoleLead
Funding Start2014
Funding Finish2014
GNoG1401410
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

20135 grants / $1,295,433

Inflammometry in Stable COPD; A Randomised Controlled Trial (RCT)$717,071

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamConjoint Professor Peter Gibson, Associate Professor Vanessa McDonald, Associate Professor Jodie Simpson, Conjoint Professor Peter Wark
SchemeProject Grant
RoleInvestigator
Funding Start2013
Funding Finish2013
GNoG1200185
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Enhancing innate immune responses to influenza in chronic obstructive pulmonary disease$504,552

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamConjoint Professor Peter Wark, Professor Phil Hansbro, Professor James Mahony
SchemeProject Grant
RoleLead
Funding Start2013
Funding Finish2013
GNoG1200206
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

BD FACSCanto II Violet Laser (405nm) upgrade including Trigon and 2 photomultiplier tubes (PMTs)$25,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamConjoint Professor Peter Wark, Doctor Alan Hsu, Doctor Katie Baines, Associate Professor Jodie Simpson, Conjoint Professor Peter Gibson, Ms Hayley See
SchemeEquipment Grant
RoleLead
Funding Start2013
Funding Finish2013
GNoG1201180
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

Protecting Pregnant Women from Death during influenza epidemics$25,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamProfessor Roger Smith, Professor Phil Hansbro, Conjoint Professor Peter Wark
SchemeProject Grant
RoleInvestigator
Funding Start2013
Funding Finish2013
GNoG1301181
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

Mechanisms of impaired antiviral interferon response to influenza infection in primary bronchial epithelial cells from chronic obstructive pulmonary disease$23,810

Funding body: John Hunter Hospital Charitable Trust Fund

Funding bodyJohn Hunter Hospital Charitable Trust Fund
Project TeamDoctor Alan Hsu, Conjoint Professor Peter Wark
SchemeResearch Grant
RoleInvestigator
Funding Start2013
Funding Finish2013
GNoG1300711
Type Of FundingOther Public Sector - State
Category2OPS
UONY

20121 grants / $33,076

Body plethysmograph respiratory function system$33,076

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamConjoint Professor Peter Gibson, Conjoint Professor Peter Wark, Associate Professor Lisa Wood, Associate Professor Jodie Simpson, Doctor Katie Baines, Doctor Vanessa Murphy, Doctor Jeffrey Pretto, Emeritus Professor Michael Hensley, Ms Jenny Mackney
SchemeEquipment Grant
RoleInvestigator
Funding Start2012
Funding Finish2012
GNoG1100973
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

20117 grants / $1,975,247

Identifying new therapeutic targets for preventing the induction and progression of COPD$626,732

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Phil Hansbro, Conjoint Professor Peter Wark
SchemeProject Grant
RoleInvestigator
Funding Start2011
Funding Finish2011
GNoG1000252
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Role of Placental Retroviral Protein Syncytin Carried on Exosomes in Mediating Vulnerability of Pregnant Women to Influenza$622,968

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Roger Smith, Conjoint Professor Peter Wark
SchemeProject Grant
RoleInvestigator
Funding Start2011
Funding Finish2011
GNoG1000294
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Understanding the mechanisms of respiratory viral infection- and COPD-induced predisposition to secondary bacterial pneumonia $573,390

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Phil Hansbro, Conjoint Professor Peter Wark
SchemeProject Grant
RoleInvestigator
Funding Start2011
Funding Finish2011
GNoG1000248
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Research microscope, confocal ready nikon eclipse 90i microscope$69,157

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Roger Smith, Conjoint Professor Tam Zakar, Professor Jon Hirst, Doctor Kaushik Maiti, Doctor Gemma Madsen, Professor Rodney Scott, Conjoint Professor Peter Wark, Laureate Professor Paul Foster, Professor Phil Hansbro, Conjoint Professor Ian Wright
SchemeEquipment Grant
RoleInvestigator
Funding Start2011
Funding Finish2011
GNoG1100024
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

SCIREQ FlexiVentFX system + FlexiVentFX extension$45,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Phil Hansbro, Laureate Professor Paul Foster, Professor Joerg Mattes, Doctor Simon Keely, Doctor Jay Horvat, Doctor Nicole Hansbro, Doctor Ming Yang, Doctor Catherine Ptaschinski, Doctor Kelly Asquith, Doctor Gough Au, Conjoint Professor Peter Wark, Laureate Professor John Aitken, Conjoint Professor Keith Jones, Professor Roger Smith, Professor Judith Black, Professor Rakesh Kumar, Professor Paul Hertzog
SchemeEquipment Grant
RoleInvestigator
Funding Start2011
Funding Finish2011
GNoG1100037
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

To determine if asthmatics and children at risk of asthma that develop acute exacerbations have defective antiviral innate immune responses$28,000

Funding body: John Hunter Hospital Charitable Trust Fund

Funding bodyJohn Hunter Hospital Charitable Trust Fund
Project TeamConjoint Professor Peter Wark, Doctor Larry Roddick, Associate Professor Lisa Wood
SchemeResearch Grant
RoleLead
Funding Start2011
Funding Finish2011
GNoG1100177
Type Of FundingOther Public Sector - State
Category2OPS
UONY

Lung Function (Spirometry) testing and sputum induction equipment - establishing 3 new clinical workstations. Medgraphics CPFS/d USB spirometer with breezesuite software (x3). Laptop computer (x3). Ul$10,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamConjoint Professor Peter Gibson, Associate Professor Jodie Simpson, Associate Professor Lisa Wood, Doctor Katie Baines, Conjoint Professor Peter Wark, Doctor Vanessa Murphy
SchemeEquipment Grant
RoleInvestigator
Funding Start2011
Funding Finish2011
GNoG1100038
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

20102 grants / $59,000

Real time PCR machine (Mastercycler ep realplex2 from Epprndorf) $34,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamAssociate Professor Jodie Simpson, Conjoint Professor Peter Gibson, Conjoint Professor Peter Wark, Associate Professor Lisa Wood, Doctor Vanessa Murphy, Doctor Robert Scott, Doctor Katie Baines
SchemeEquipment Grant
RoleInvestigator
Funding Start2010
Funding Finish2010
GNoG1000056
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

Identifying novel biomarkers of oxidative stress in chronic obstructive pulmonary disease$25,000

Funding body: Hunter Children`s Research Foundation

Funding bodyHunter Children`s Research Foundation
Project TeamConjoint Professor Peter Wark, Associate Professor Lisa Wood
SchemeResearch Grant
RoleLead
Funding Start2010
Funding Finish2010
GNoG0900145
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

20093 grants / $72,000

394591 ELx405UV select plate washer and workstation integration kit$27,500

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamConjoint Professor Peter Gibson, Doctor Xiao Yan He, Associate Professor Jodie Simpson, Associate Professor Lisa Wood, Conjoint Professor Peter Wark
SchemeEquipment Grant
RoleInvestigator
Funding Start2009
Funding Finish2009
GNoG0189853
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

Development of novel therapeutic approaches for rhinovirus - induced asthma exacerbation$24,500

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamProfessor Joerg Mattes, Laureate Professor Paul Foster, Conjoint Professor Peter Wark
SchemeProject Grant
RoleInvestigator
Funding Start2009
Funding Finish2009
GNoG0189800
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Treatment of subjects with cystic fibrosis who are colonised with aspergillus fumigatus$20,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamConjoint Professor Peter Wark, Associate Professor Scott Bell, Associate Professor Peter Bye, Associate Professor Adam Jaffe, Dr Hiran Selvadurai, Professor Phillip Robinson
SchemeNear Miss Grant
RoleLead
Funding Start2009
Funding Finish2009
GNoG0189818
Type Of FundingInternal
CategoryINTE
UONY

20087 grants / $2,375,221

Inflammatory mechanisms of airways disease$925,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamConjoint Professor Peter Wark
SchemeProject Grant
RoleLead
Funding Start2008
Funding Finish2008
GNoG0189566
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Inflammatory mechanisms of airways disease$925,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamConjoint Professor Peter Wark
SchemeProject Grant
RoleLead
Funding Start2008
Funding Finish2008
GNoG0189566
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

The mechanisms of infection of bronchial epithelial cells by human & avian influenza viruses in chronic airways disease$379,650

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamConjoint Professor Peter Wark, Professor Phil Hansbro, Dr Ian Barr
SchemeProject Grant
RoleLead
Funding Start2008
Funding Finish2008
GNoG0187593
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

The use of the components of the bacteria, streptococcus pneumoniae, as novel immunotherapies for asthma$50,000

Funding body: Asthma Foundation of New South Wales

Funding bodyAsthma Foundation of New South Wales
Project TeamProfessor Phil Hansbro, Professor Rakesh Kumar, Conjoint Professor Peter Wark
SchemeResearch Grant
RoleInvestigator
Funding Start2008
Funding Finish2008
GNoG0188434
Type Of FundingDonation - Aust Non Government
Category3AFD
UONY

Mechanisms of inflammatory airways disease$40,571

Funding body: Markey Insurance

Funding bodyMarkey Insurance
Project TeamConjoint Professor Peter Wark
SchemeHMRI Grant
RoleLead
Funding Start2008
Funding Finish2008
GNoG0189370
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

Becton Dickinson high throughout sampler for the FACSCanto II cytometry system$35,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamConjoint Professor Peter Wark, Conjoint Professor Peter Gibson, Associate Professor Jodie Simpson, Associate Professor Lisa Wood, Doctor Vanessa Murphy, Professor Phil Hansbro
SchemeEquipment Grant
RoleLead
Funding Start2008
Funding Finish2008
GNoG0188547
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

PP2A: A new target for asthma therapy$20,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Alistair Sim, Doctor Nikki Verrills, Professor John Scott, Conjoint Professor Peter Wark
SchemeNear Miss Grant
RoleInvestigator
Funding Start2008
Funding Finish2008
GNoG0188395
Type Of FundingInternal
CategoryINTE
UONY

20078 grants / $546,848

Chronic Exposure of Bronchial Epithelial Cells to Bacterial Components Modifies their Innate Immune Response to Infection with Respiratory Viruses$313,500

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamConjoint Professor Peter Wark
SchemeProject Grant
RoleLead
Funding Start2007
Funding Finish2007
GNoG0186439
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

In vitro response of bronchial epithelial cells and activation of lymphocytes to infection with rhinovirus$58,848

Funding body: John Hunter Hospital Charitable Trust Fund

Funding bodyJohn Hunter Hospital Charitable Trust Fund
Project TeamConjoint Professor Peter Wark, Professor Phil Hansbro, Associate Professor Jodie Simpson
SchemeResearch Grant
RoleLead
Funding Start2007
Funding Finish2007
GNoG0188095
Type Of FundingDonation - Aust Non Government
Category3AFD
UONY

Differential regulation of human mast cell degranulation by discrete forms of protein phosphatase 2A$50,000

Funding body: Asthma Foundation of New South Wales

Funding bodyAsthma Foundation of New South Wales
Project TeamProfessor Alistair Sim, Doctor Nikki Verrills, Laureate Professor Paul Foster, Conjoint Professor Peter Wark, Conjoint Professor Peter Gibson, Dr Gregory Kranias
SchemeResearch Grant
RoleInvestigator
Funding Start2007
Funding Finish2007
GNoG0187247
Type Of FundingDonation - Aust Non Government
Category3AFD
UONY

Nitric Oxide Monitoring System (NIOX)$45,000

Funding body: NHMRC (National Health & Medical Research Council)

In vitro response of bronchial epithelial cells and activation of lymphocytes from COPD patients by infection with rhinovirus, respiratory syncytial virus and haemophilus influenza$25,000

Funding body: GlaxoSmithKline Australia

Funding bodyGlaxoSmithKline Australia
Project TeamConjoint Professor Peter Wark, Professor Phil Hansbro, Associate Professor Jodie Simpson
SchemeSupport Grant
RoleLead
Funding Start2007
Funding Finish2007
GNoG0188309
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Hewlett Packard 7890 series gas chromatograph with accessories$20,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamAssociate Professor Lisa Wood, Conjoint Professor Peter Wark, Conjoint Professor Peter Gibson, Associate Professor Jodie Simpson, Doctor Vanessa Murphy, Laureate Professor Paul Foster, Professor Phil Hansbro, Conjoint Associate Professor Vicki Clifton, Professor Clare Collins, Conjoint Professor Wayne Smith, Professor John Attia
SchemeEquipment Grant
RoleInvestigator
Funding Start2007
Funding Finish2007
GNoG0188191
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

Class II biohazard containment hood and carbon dioxide cell culture incubator$20,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamConjoint Professor Peter Wark, Conjoint Professor Peter Gibson, Associate Professor Jodie Simpson, Doctor Vanessa Murphy, Associate Professor Lisa Wood, Laureate Professor Paul Foster, Professor Phil Hansbro
SchemeEquipment Grant
RoleLead
Funding Start2007
Funding Finish2007
GNoG0188192
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

Miccroarrays to identify novel therapeutic targets for bird flu$14,500

Funding body: John Hunter Hospital Charitable Trust Fund

Funding bodyJohn Hunter Hospital Charitable Trust Fund
Project TeamConjoint Professor Peter Wark, Professor Phil Hansbro
SchemeResearch Grant
RoleLead
Funding Start2007
Funding Finish2007
GNoG0187337
Type Of FundingOther Public Sector - State
Category2OPS
UONY

20064 grants / $793,907

PRC Priority Research Centre for Asthma & Respiratory Diseases$524,282

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamLaureate Professor Paul Foster, Conjoint Professor Peter Gibson, Conjoint Professor Kenneth Beagley, Emeritus Professor Michael Hensley, Professor Phil Hansbro, Professor Joerg Mattes, Professor Alistair Sim, Conjoint Professor Peter Wark
SchemePriority Research Centre
RoleInvestigator
Funding Start2006
Funding Finish2006
GNoG0186914
Type Of FundingInternal
CategoryINTE
UONY

Surveillance and Analysis of Avian Influenza Viruses in Migratory Birds in Australia$249,625

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Phil Hansbro, Dr Ian Barr, Conjoint Professor Peter Wark, Dr Paul Selleck, Dr Simone Warner, Laureate Professor Paul Foster, Dr Aeron Hurt, Dr Irene Peroulis, Dr John Curran, Conjoint Professor Peter Gibson
SchemePotential Avian Influenza-Induced Pandemic
RoleInvestigator
Funding Start2006
Funding Finish2006
GNoG0186000
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

The interaction between airway epithelial cells infected with rhinovirus and lymphocytes from subjects with COPD$15,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamConjoint Professor Peter Wark
SchemeProject Grant
RoleLead
Funding Start2006
Funding Finish2006
GNoG0186106
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Equipment - Microscope$5,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamConjoint Professor Peter Wark
SchemePULSE Early Career Researcher of the Year Award
RoleLead
Funding Start2006
Funding Finish2006
GNoG0186168
Type Of FundingNot Known
CategoryUNKN
UONY

20011 grants / $338,516

Mechanisms of bronchial epithelial cell activation in rhinovirus infection in asthma, COAD and normal airways$338,516

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamConjoint Professor Peter Wark
SchemeTraining (Postdoctoral) Fellowships - Neil Hamilton Fairley Clinical Fellowship (Overseas)
RoleLead
Funding Start2001
Funding Finish2001
GNoG0180753
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

19981 grants / $45,500

The investigation of airway inflammation and cell death in acute severe asthma$45,500

Funding body: Asthma Foundation of New South Wales

Funding bodyAsthma Foundation of New South Wales
Project TeamConjoint Professor Peter Gibson, Conjoint Professor Peter Wark
SchemeResearch Grant
RoleInvestigator
Funding Start1998
Funding Finish1998
GNoG0177660
Type Of FundingDonation - Aust Non Government
Category3AFD
UONY
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Research Supervision

Current Supervision

CommencedResearch Title / Program / Supervisor Type
2015Identification of Abnormalities in Innate Immunity in Asthma
General Medicine, Faculty of Health and Medicine
Principal Supervisor
2015Contribution of Cell Death to the Pathogenesis of Chronic Obstructive Pulmonary Disease (COPD)
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2015What is the Impact of Bubble Humidification on Patient Comfort, Oxygenation and Respiratory Tract Infection Rates in Adult Patients Requiring Low-Flow Supplemental Oxygen?
Nursing, Faculty of Health and Medicine
Co-Supervisor
2014Chronic Obstructive Pulmonary Disease (COPD)
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2013The Role of the PI3K Signalling Pathway in the Innate Antiviral Response of Airway Epithelial Cells
General Medicine, Faculty of Health and Medicine
Principal Supervisor
2013Investigation of the pathogenesis and potential therapeutic interventions of influenza in Asthma and COPD
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2010Indentification of New Therapeutics in COPD/ Emphysema
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2009Mechanisms of Increased Susceptibility to Influenza Infection in Mouse Models of Chronic Lung Disease
Microbiology, Faculty of Health and Medicine
Co-Supervisor

Past Supervision

YearResearch Title / Program / Supervisor Type
2015Characterising Innate Immune Responses and the Role of PD-1 in Patients with COPD
General Medicine, Faculty of Health and Medicine
Principal Supervisor
2015Oxidative Stress Impairs Mitochondrial Function in Healthy and Asthmatic Primary Bronchial Epithelial Cells
General Medicine, Faculty of Health and Medicine
Principal Supervisor
2014Role of Antioxidants in Rhinovirus-Infected Airway Epithelial Cells
Medical Science, Faculty of Health and Medicine
Co-Supervisor
2013Investigation of the Immune Mechanisms in Pregnancy and Asthma Leading to Increased Susceptibility and Disease Severity to Respiratory Virus Infections
General Medicine, Faculty of Health and Medicine
Co-Supervisor
2013An Investigation of Body Composition in People With and Without Chronic Obstructive Pulmonary Disease (COPD)
General Medicine, Faculty of Health and Medicine
Co-Supervisor
2011Immune Mechanisms that Promote the Development of Inducible Bronchus-Associated Lymphoid Tissue (IBALT)
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2010Mechanism of Infection of Bronchial Epithelial Cells by Human and Avian Influenza Viruses
General Medicine, Faculty of Health and Medicine
Principal Supervisor
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News

Conjoint Professor Peter Wark

New asthma therapy

August 26, 2014

A new therapy developed by Hunter Medical Research Institute (HMRI) and UK-based respiratory researchers has recorded a marked reduction in acute asthma exacerbations triggered by the common cold.

Conjoint Professor Peter Wark

Position

Conjoint Professor
Centre for Asthma and Respiratory Disease
School of Medicine and Public Health
Faculty of Health and Medicine

Focus area

Immunology and Microbiology

Contact Details

Emailpeter.wark@newcastle.edu.au
Phone(02) 40420110
Fax(02) 4985 5850

Office

Room2107
BuildingLevel 2, West HMRI building
LocationLot 1 Kookaburra Close New Lambton

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