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Career Summary

Biography

Peter Wark is a senior staff specialist in Respiratory and Sleep Medicine at John Hunter Hospital, Newcastle and a conjoint Associate Professor with the University of Newcastle. In addition he is co-director of the Priority Research Centre for Asthma and Respiratory Diseases and a member of the Vaccines Immunology Viruses and Asthma research group at the Hunter Medical Research Institute. He has been a member of the TSANZ executive board since and chairman of the clinical care and resources subcommittee since 2011.

His research interests are in the area of infection and the impact this has on inflammatory airways disease, with a particular interest in viral respiratory infections. His group has developed expertise in identifying respiratory viruses in airway secretions and developing an in-vitro cell culture model of the airway epithelium that we use to model the effect of infection and inflammation. He is the centre director for the John Hunter Adult Cystic Fibrosis clinic that manages 75 adult patients with CF in the context of a multidisciplinary team. He is area director for the oxygen and related products scheme and lead physician for the advanced respiratory failure clinic. He is chairperson for the Hunter New England Local Hospital network respiratory stream, responsible for the provision of respiratory services throughout the Hunter New England area, with a catchment population of 840,000.

Peter qualified as a Bachelor of Medicine at the University of Newcastle, Australia in 1991 and qualified as a specialist in Respiratory and Sleep Medicine as a Fellow of the Royal Australasian College of Physicians in 1999.

From 2001-2005 he was a post doctoral research fellow under an NHMRC Neil Hamilton Fairley Travelling Fellowship at the University of Southampton and University College London, under the supervision of Professors Stephen Holgate, Donna Davies and Sebastian Johnston.

From 1998-2001 he completed a PhD under the supervision of Professors Peter Gibson and Michael Hensley at the University of Newcastle, Australia.

Peter is married to Katrina, and parents to Kirsty, Marden, Jasmine, Sarah, David, Charlotte and Eliza.

Qualifications

  • PhD, University of Newcastle, 30/06/2001
  • Bachelor of Medicine, University of New South Wales, 31/12/1991

Research

Research keywords

  • Airway inflammation
  • Asthma
  • COPD
  • Immunology
  • Respiratory Medicine
  • Virology

Research expertise

My current research interests include the role of virus infection in acute exacerbations of airways disease and their influence on airway inflammation. Active research programmes include the investigation of innate immune function of the airway epithelium in response to virus infection and the interaction with other components of the cellular immune system. These projects involve the use of invitro cell culture models to study mechanisms of disease and inflammation especially in respect to viral and bacterial infection, the isolation, sequencing and characterisation of respiratory viruses from clinical specimens. Clinical studies currently focus on the effect of infection in acute exacerbations of asthma, COPD and cystic fibrosis lung disease.

I undertook a post-doctoral research project that is collaboration between Professor Stephen Holgate and Professor Sebastian Johnston. The project is titled “Mechanisms of bronchial epithelial cell activation in response to rhinovirus infection in asthma COPD and normal airways. The aim is to characterise the response and interaction of cultured human bronchial epithelial and mesenchymal cells to experimental rhinovirus infection. The aim is to contrast and compare the inflammatory and reparative response in cells from subjects with varying severities of asthma, COPD and normal controls.

During this time I have established expertise with in-vitro culture of tissue cell lines and primary bronchial epithelial cells. In collaboration with Professor Sebastian Johnston I have also established techniques that have enabled me to culture Rhinovirus and infect epithelial cells. We assessed the cytotoxic effect of infection on epithelial cells and determined the mechanisms of cell death using flow cytometry and Annexin binding. In addition the inflammatory response between asthmatic epithelial cells and healthy controls was compared in terms of release of pro-inflammatory mediators, type I interferons and factors that may influence myofibroblast proliferation, by measuring mRNA production using quantifiable PCR in conjunction with protein expression as measured by ELISA. This data has presented at international meetings and is awaiting publication. In the last eighteen months we have received further funding from the UK National Asthma Campaign and the British Medical Association to extend this work examining the effect of infection on an epithelial-mesenchymal co-culture model to determine if there is a relationship between infection and airway wall remodelling and are exploring in greater detail early epithelial intracellular signalling events following infection, particularly in reference to oxidative pathways and interferon ?/? signalling.

My research group specialises in:

1. Primary airway epithelial cell culture, especially in regard to responses to infection and inflammation.

2. Basic mechanisms of innate immune responses pathways, with an emphaisis on epithelial cell responses, dendritic cell responses and innate lymphoid responses.

3. Innate and adaptive immune responses to respiratory virus infection, with a special interest in influenza and rhinovirus

Fields of Research

CodeDescriptionPercentage
110203Respiratory Diseases50
110700Immunology25
110804Medical Virology25

Memberships

Body relevant to professional practice.

  • Fellow - American Thoracic Society

Editorial Board.

  • Editor - International Cochrane collaboration
  • Editor - Clinical and experimental allergy

NHMRC Committee

  • Member - Translational research

National & International Standards Committees.

  • Fellow - Thoracic Society of Australia and New Zealand

Collaboration

Our clinical studies currently focus on the effect of infection in acute exacerbations of asthma, COPD and cystic fibrosis lung disease. Ongoing clinical research programmes are active with Prof Peter Gibson, Dr L Wood. We are currently taking part in a multi-centre RCt of non-CF bronchiectasis in collaboration with Royal Prince Alfred Hospital Sydney and Prince Charles Hospital Brisbane. We are an active site involved in the national influenza surveillance programme "Flucan".

This works involves an effective collaboration between other members of the VIVA group and priority research centre in the areas of clinical research and translational research using animal models with Prof P Hansbro, Prof J Mattes, Prof P Forster.

We have an active NHMRC grant looking at the immunology and susceptibility of virus infection in pregnancy with Prof R Smith.

Teaching

Teaching keywords

  • Immunolgy
  • Internal medicine
  • Respiratory medicine
  • Sleep medicine

Teaching expertise

Supervison of honours and PhD students in the areas airway inflammation, infection and respiratory disease.

I am responsible for funding and supervising 2.0 FTE research assistants and 2.0 FTE post-doctoral research fellows. I have supervised two students who have completed and been awarded their PhD, 2 further students who have completed their doctoral studies and will submit their thesis in 2012 and 3 students that completed their honours year. I am currently the primary supervisor for two PhD students and a secondary supervisor for another three.

For the School of Medicine and Public Health, Faculty of Health, University of Newcastle I have regular lecture commitments to years 2, 3, 4 and 5. In addition I act as a clinical tutor for students in year 3, 4 and 5. My direct University teaching commitments are 2.5 hours per week.

Supervision of post graduate students:

I currently supervise 3 students enrolled in PhDs and one student enrolled in a masters degree with the Faculty of Health, University of Newcastle.

I have supervised the following students that have completed and been awarded PhD with the University of Newcastle.

1. Dr Rebecca Forbes awarded 2012

2. Dr Alan Hsu, awarded 2011

2. Dr Shen Yun Adeline Foo, awarded 2011

3. Dr Ahmed Saedsomaelia, awarded 2009

I have supervised the following students that have completed and been awarded honours with the University of Newcastle.

1. Ms Su Ling Loo, First class Honours awarded 2010.

2. Ms Hayley See,

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Highlighted Publications

For publications that are currently unpublished or in-press, details are shown in italics.

YearCitationAltmetricsLink
2005Wark PA, Johnston S, Bucchieri F, Powell R, Puddicombe S, Laza-Stanca V, et al., 'Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus', Journal of Experimental Medicine, 201 937-947 (2005) [C1]
2006Contoli M, Message SD, Laza-Stanca V, Edwards MR, Wark PA, Bartlett N, et al., 'Role of eficient type III interferon-lambda production in asthma exacerbations', Nature Medicine, 12 1023-1026 (2006) [C1]
2013Collison AM, Hatchwell LM, Verrills NM, Wark PA, Pereira De Siqueira AL, Tooze MK, et al., 'The E3 ubiquitin ligase midline 1 promotes allergen and rhinovirus-induced asthma by inhibiting protein phosphatase 2A activity', Nature Medicine, 19 232-237 (2013) [C1]
2013Vanders RL, Gibson PG, Murphy VE, Wark PAB, 'Plasmacytoid Dendritic Cells and CD8 T Cells From PregnantWomen Show Altered Phenotype and Function Following H1N1/09 Infection', JOURNAL OF INFECTIOUS DISEASES, 208 1062-1070 (2013) [C1]
2012Hsu A, Parsons KS, Barr I, Lowther S, Middleton D, Hansbro PM, Wark PA, 'Critical role of constitutive type I interferon response in bronchial epithelial cell to influenza infection', PLoS One, 7 e32947 (2012) [C1]

Publications

For publications that are currently unpublished or in-press, details are shown in italics.

Click on a category title below to expand the list of citations for that specific category.

Chapter (2 outputs)

YearCitationAltmetricsLink
2011Wark PA, Hayes M, 'Respiratory examination', Clinical Examination: A Problem Based Approach, World Scientific Publishing, Singapore 17-40 (2011) [B2]
2010Wark PA, Gibson PG, 'Pathogenesis of ABPA', Aspergillosis: From diagnosis to prevention, Springer, Berlin 695-706 (2010) [B1]

Co-authors: Peter Gibson

Journal article (67 outputs)

YearCitationAltmetricsLink
2014Wark PAB, Murphy V, Mattes J, 'The interaction between mother and fetus and the development of allergic asthma', Expert Review of Respiratory Medicine, 8 57-66 (2014)
2014Parsons KS, Hsu AC, Wark PAB, 'TLR3 and MDA5 signalling, although not expression, is impaired in asthmatic epithelial cells in response to rhinovirus infection.', CLINICAL AND EXPERIMENTAL ALLERGY, 44 91-101 (2014)
2013Baines KJ, Hsu AC-Y, Tooze M, Gunawardhana LP, Gibson PG, Wark PAB, 'Novel immune genes associated with excessive inflammatory and antiviral responses to rhinovirus in COPD', RESPIRATORY RESEARCH, 14 (2013) [C1]
2013Collison AM, Hatchwell LM, Verrills NM, Wark PA, Pereira De Siqueira AL, Tooze MK, et al., 'The E3 ubiquitin ligase midline 1 promotes allergen and rhinovirus-induced asthma by inhibiting protein phosphatase 2A activity', Nature Medicine, 19 232-237 (2013) [C1]
2013Vanders RL, Gibson PG, Wark PAB, Murphy VE, 'Alterations in inflammatory, antiviral and regulatory cytokine responses in peripheral blood mononuclear cells from pregnant women with asthma', RESPIROLOGY, 18 827-833 (2013) [C1]
2013Vanders RL, Gibson PG, Murphy VE, Wark PAB, 'Plasmacytoid Dendritic Cells and CD8 T Cells From PregnantWomen Show Altered Phenotype and Function Following H1N1/09 Infection', JOURNAL OF INFECTIOUS DISEASES, 208 1062-1070 (2013) [C1]
2013Wark PAB, Tooze M, Powell H, Parsons K, 'Viral and bacterial infection in acute asthma and chronic obstructive pulmonary disease increases the risk of readmission', RESPIROLOGY, 18 996-1002 (2013) [C1]
2013Beckett EL, Stevens RL, Jarnicki AG, Kim RY, Hanish I, Hansbro NG, et al., 'A new short-term mouse model of chronic obstructive pulmonary disease identifies a role for mast cell tryptase in pathogenesis', The Journal of Allergy and Clinical Immunology, 131 752-762 (2013) [C1]
2013Murphy VE, Powell H, Wark PAB, Gibson PG, 'A Prospective Study of Respiratory Viral Infection in Pregnant Women With and Without Asthma', CHEST, 144 420-427 (2013) [C1]
2013Cheng AC, Holmes M, Irving LB, Brown SGA, Waterer GW, Korman TM, et al., 'Influenza Vaccine Effectiveness against Hospitalisation with Confirmed Influenza in the 2010-11 Seasons: A Test-negative Observational Study', PLOS ONE, 8 (2013) [C1]
2012Wark PA, Tooze M, Cheese L, Whitehead BF, Gibson PG, Wark K, McDonald VM, 'Viral infections trigger exacerbations of cystic fibrosis in adults and children', European Respiratory Journal, 40 510-512 (2012) [C1]
2012Vanders RL, Gibson PG, Murphy VE, Wark PAB, 'Impaired type I and III interferon response to rhinovirus infection during pregnancy and asthma', Thorax, 67 209-214 (2012) [C1]
2012Sukkar MB, Wood LG, Tooze MK, Simpson JL, McDonald VM, Gibson PG, Wark PA, 'Soluble RAGE is deficient in neutrophilic asthma and COPD', European Respiratory Journal, 39 721-729 (2012) [C1]
2012Ryan NM, Vertigan AE, Ferguson JK, Wark PA, Gibson PG, 'Clinical and physiological features of postinfectious chronic cough associated with H1N1 infection', Respiratory Medicine, 106 138-144 (2012) [C1]
2012Bozinovski S, Uddin M, Vlahos R, Thompson M, McQualter JL, Merritt A-S, et al., 'Serum amyloid A opposes lipoxin A(4) to mediate glucocorticoid refractory lung inflammation in chronic obstructive pulmonary disease', Proceedings of the National Academy of Sciences of the United States of America, 109 935-940 (2012) [C1]
2012Hsu A, Parsons KS, Barr I, Lowther S, Middleton D, Hansbro PM, Wark PA, 'Critical role of constitutive type I interferon response in bronchial epithelial cell to influenza infection', PLoS One, 7 e32947 (2012) [C1]
2012Hurt AC, Hardie K, Wilson NJ, Deng YM, Osbourn M, Leang SK, et al., 'Characteristics of a widespread community cluster of H275Y Oseltamivir-Resistant A (H1N1)pdm09 influenza in Australia', Journal of Infectious Diseases, 206 148-157 (2012) [C1]
2012Pretto JJ, McDonald VM, Wark PA, Hensley MJ, 'Multicentre audit of inpatient management of acute exacerbations of chronic obstructive pulmonary disease: comparison with clinical guidelines', Internal Medicine Journal, 42 380-387 (2012) [C1]
2012Vanders RL, Wark PA, Murphy VE, Gibson PG, 'Pregnant women have attenuated innate interferon responses to 2009 pandemic influenza a virus subtype H1N1', Journal of Infectious Diseases, 206 646-653 (2012) [C1]
2012Vlahos R, Wark PAB, Anderson GP, Bozinovski S, 'Glucocorticosteroids Differentially Regulate MMP-9 and Neutrophil Elastase in COPD', PLOS ONE, 7 (2012) [C1]
2012Hsu A, See HV, Hansbro PM, Wark PA, 'Innate immunity to influenza in chronic airways diseases', Respirology, 17 1166-1175 (2012) [C1]
2012Sukkar MB, Ullah MA, Gan WJ, Wark PA, Chung KF, Hughes JM, et al., 'RAGE: a new frontier in chronic airways disease', British Journal of Pharmacology, 167 1161-1176 (2012) [C1]
2012Wark PA, 'Airway inflammation in asthma, a single measurement is not enough', Respirology, 17 393-394 (2012) [C3]
2011Cheng AC, Kotsimbos T, Kelly HA, Irving LB, Bowler SD, Brown SGA, et al., 'Effectiveness of H1N1/09 monovalent and trivalent influenza vaccines against hospitalization with laboratory-confirmed H1N1/09 influenza in Australia: A test-negative case control study', Vaccine, 29 7320-7325 (2011) [C1]
2011Wood LG, Simpson JL, Wark PA, Powell H, Gibson PG, 'Characterization of innate immune signalling receptors in virus-induced acute asthma', Clinical and Experimental Allergy, 41 640-648 (2011) [C1]
2011Hsu A, Barr I, Hansbro PM, Wark PA, 'Human influenza is more effective than Avian influenza at antiviral suppression in airway cells', American Journal of Respiratory Cell and Molecular Biology, 44 906-913 (2011) [C1]
2011Katelaris CH, Linneberg A, Magnan A, Thomas WR, Wardlaw AJ, Wark PA, 'Developments in the field of allergy in 2010 through the eyes of Clinical and Experimental Allergy', Clinical and Experimental Allergy, 41 1690-1710 (2011) [C3]
2011Wark PA, 'Tiotropium reduced exacerbations more than salmeterol in moderate-to-very severe COPD', Annals of Internal Medicine, 155 3 (2011) [C3]
2010Wood LG, Wark PA, Garg ML, 'Antioxidant and anti-inflammatory effects of resveratrol in airway disease', Antioxidants & Redox Signaling, 13 1535-1548 (2010) [C1]
2010Reddel HK, Gibson PG, Peters MJ, Wark PA, Sand IB, Hoyos CM, Jenkins CR, 'Down-titration from high-dose combination therapy in asthma: Removal of long-acting b2-agonist', Respiratory Medicine, 104 1110-1120 (2010) [C1]
2010Osei-Kumah A, Wark PA, Smith R, Clifton VL, 'Asthma during pregnancy alters immune cell profile and airway epithelial chemokine release', Inflammation Research, 59 349-358 (2010) [C1]
2010Wark PA, 'Viral and bacterial interactions in pneumonia', Expert Review of Respiratory Medicine, 4 221-228 (2010) [C1]
2009Saedi Some Olia A, Wood LG, Garg ML, Gibson PG, Wark PA, 'Lycopene enrichment of cultured airway epithelial cells decreases the inflammation induced by rhinovirus infection and lipopolysaccharide', Journal of Nutritional Biochemistry, 20 577-585 (2009) [C1]
2009Wark PA, McDonald VM, 'Nebulised hypertonic saline for cystic fibrosis', Cochrane Database of Systematic Reviews, - CD001506 (2009) [C1]
2009Saedi Some Olia A, Wood LG, Garg ML, Gibson PG, Wark PA, 'Anti-inflammatory effects of long-chain n-3 PUFA in rhinovirus-infected cultured airway epithelial cells', British Journal of Nutrition, 101 533-540 (2009) [C1]
2009Wark PA, Grissell TV, Davies BL, See HV, Gibson PG, 'Diversity in the bronchial epithelial cell response to infection with different rhinovirus strains', Respirology, 14 180-186 (2009) [C1]
2008Oliver BGG, Lim S, Wark PA, Laza-Stanca V, King N, Black JL, et al., 'Rhinovirus exposure impairs immune responses to bacterial products in human alveolar macrophages', Thorax, 63 519-525 (2008) [C1]
2008Simpson JL, Wark PA, 'The role of exhaled nitric oxide and exhaled breath condensates in evaluating airway inflammation in asthma', Expert Opinion on Medical Diagnostics, 2 607-620 (2008) [C1]
2008Hansbro NG, Horvat JC, Wark PA, Hansbro PM, 'Understanding the mechanisms of viral induced asthma: New therapeutic directions', Pharmacology & Therapeutics, 117 313-353 (2008) [C1]
2008See HV, Wark PA, 'Innate immune response to viral infection of the lungs', Paediatric Respiratory Reviews, 9 243-250 (2008) [C1]
2008Saedi Some Olia A, Wood LG, Garg ML, Gibson PG, Wark PA, 'Supplementation of long chain N-3 polyunsaturated fatty acids increases the utilization of lycopene in cultured airway epithelial cells', Journal of Food Lipids, 15 421-432 (2008) [C1]
2008Wark PA, 'Guest editorial', Paediatric Respiratory Reviews, 9 233-235 (2008) [C3]
2007Wark PA, Bucchieri F, Johnston SL, Gibson PG, Hamilton L, Mimica J, et al., 'IFN-gamma-induced protein 10 is a novel biomarker of rhinovirus-induced asthma exacerbations', Journal of Allergy and Clinical Immunology, 120 586-593 (2007) [C1]
2007Weckmann M, Collison A, Simpson JL, Kopp MV, Wark PA, Smyth MJ, et al., 'Critical link between TRAIL and CCL20 for the activation of T(H)2 cells and the expression of allergic airway disease', Nature Medicine, 13 1308-1315 (2007) [C1]
2006Wark PA, Gibson PG, 'Asthma exacerbations 3: Pathogenesis', Thorax, 61 909-915 (2006) [C1]
2006Contoli M, Message SD, Laza-Stanca V, Edwards MR, Wark PA, Bartlett N, et al., 'Role of eficient type III interferon-lambda production in asthma exacerbations', Nature Medicine, 12 1023-1026 (2006) [C1]
2006Wark PA, 'Safety concerns with salmeterool', Australian Prescriber, 29 118-119 (2006) [C3]
2005Wood LG, Garg ML, Simpson JL, Mori TA, Croft KD, Wark PA, Gibson PG, 'Induced sputum 8-isoprostane concentrations in inflammatory airway diseases', American Journal of Respiratory and Critical Care Medicine, 171 426-430 (2005) [C1]
2005Wark PA, Johnston S, Bucchieri F, Powell R, Puddicombe S, Laza-Stanca V, et al., 'Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus', Journal of Experimental Medicine, 201 937-947 (2005) [C1]
2005Wark PAB, McDonald V, Jones AP, 'Nebulised hypertonic saline for cystic fibrosis', COCHRANE DATABASE OF SYSTEMATIC REVIEWS, (2005)
2004Wark PA, 'Pathogenesis of allergic bronchopulmonary aspergillosis and an evidence-based review of azoles in treatment', Respiratory Medicine, 98 915-923 (2004) [C1]
2004Wark PA, 'Bronchitis (acute)', Clinical Evidence, 12 (2004) [C3]
2003Wark PA, Hensley MJ, Saltos N, Boyle MJ, Toneguzzi R, Simpson JL, et al., 'Anti-inflammatory effect of itraconazole in stable allergic bronchopulmonary aspergillosis: A randomized controlled trial', The Journal of Allergy and Clinical Immunology, 111 952-957 (2003) [C1]
2003Gibson PG, Wark PA, Simpson JL, Meldrum CJ, Meldrum S, Saltos N, Boyle MJ, 'Induced sputum IL-8 gene expression, neutrophil influx and MMP-9 in allergic bronchopulmonary aspergillosis', European Respiratory Journal, 21 582-588 (2003) [C1]
2003Simpson JL, Moric I, Wark PA, Johnston S, Gibson PG, 'Use of induced sputum for the diagnosis of influenza and infections in asthma: a comparison of diagnostic techniques', Journal of Clinical Virology, 339-346 (2003) [C1]
2002Wark PA, Johnston S, Moric I, Simpson JL, Hensley MJ, Gibson PG, 'Neutrophil degranulation and cell lysis is associated with clinical severity in virus-induced asthma', The European Respiratory Journal, 19 68-75 (2002) [C1]
2002Wark PA, Simpson JL, Hensley MJ, Gibson PG, 'Airway inflammation in thunderstorm asthma', Clinical and Experimental Allergy, 32 1750-1756 (2002) [C1]
2002Simpson JL, Gibson PG, Wark PA, 'Optimization of sputum-processing methods for the measurement of interleukin-5: Effects of protease inhibition', Respirology, 7 111-116 (2002) [C1]
2002Wark PA, Johnston S, Simpson JL, Hensley MJ, Gibson PG, 'Chlamydia pneumoniae immunoglobulin A reactivation and airway inflammation in acute asthma', The European Respiratory Journal, 20 834-840 (2002) [C1]
2001Gibson PG, Simpson J, Chalmers AC, Toneguzzi R, Wark PA, Wilson AJ, Hensley MJ, 'Airway Eosinophilia is associated with Wheeze but is uncommon in Children with Persistent Cough and Frequent Chest Colds', American Journal of Respiratory and Critical Care Medicine, 164 977-981 (2001) [C1]
2001Wark PA, Gibson PG, Johnston S, 'Exacerbations of asthma: addressing the triggers and treatments', Monaldi Archives for Chest Disease, 56 429-435 (2001) [C1]

Co-authors: Peter Gibson

2001Wark PA, Simpson J, Hensley MJ, Gibson PG, 'Safety of sputum induction with isotonic saline in adults with acute severe asthma', Clinical and Experimental Allergy, 31 1745-1753 (2001) [C1]
2001Wark PA, Gibson PG, 'Allergic bronchopulmonary aspergillosis: New concepts of pathogenesis and treatment', Respirology, 6 1-7 (2001) [C2]

Co-authors: Peter Gibson

2000Wark PA, Saltos N, Simpson J, Slater S, Hensley MJ, Gibson PG, 'Induced sputum easinophils and neutrophils and bronchiectasis severity in allergic bronchopulmonary aspergillosis', European Respiratory Journal, 16 1095-1101 (2000) [C1]
2000Wark PA, Wilson A, Gibson PG, 'Azoles for allergic bronchopulmonary aspergillosis', The Cochrane Library, 1-9 (2000) [C1]

Co-authors: Peter Gibson

2000Wark PA, Gibson PG, Fakes K, 'Induced sputum eosinophils in the assessment of asthma and chronic cough*', Respirology, 5 51-57 (2000) [C1]

Co-authors: Peter Gibson

1999Wark PAB, Fakes K, Gibson PG, 'Induced sputum eosinophils in the assessment of asthma and chronic cough.', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 159 A850-A850 (1999)
Show 64 more

Review (1 outputs)

YearCitationAltmetricsLink
2004Wark PA, Gibson PG, Wilson AJ, 'Azoles for Allergic Bronchopulmonary Aspergillosis Associated With Asthma', Cochrane Database of Systematic Reviews (2004) [D1]

Conference (73 outputs)

YearCitationAltmetricsLink
2013Zhong H, Simpson JL, Wood LG, Wark PAB, 'COPD PERIPHERAL BLOOD NEUTROPHILS HAVE ENHANCED RELEASE OF IL-1B WHEN STIMULATED', RESPIROLOGY (2013) [E3]
2013Hansbro P, Beckett E, Stevens R, Jarnicki A, Kim R, Hanish I, et al., 'A short-term model of COPD identifies a role for mast cell tryptase', JOURNAL OF IMMUNOLOGY, Honolulu, HI (2013) [E3]
2012Parsons KS, Tooze MK, Grissell TV, Bell N, Chapman JN, Ryan J, et al., 'Patterns (2007-2009) of respiratory viruses isolated from acute exacerbations of airways disease', Respirology, Canberra, ACT (2012) [E3]

Co-authors: Peter Gibson

2012McDonald VM, Wark PA, Roberts M, Spencer LM, Alison JA, Wood LG, Gibson PG, 'Development and audience testing of a COPD education DVD', Respirology, Canberra, ACT (2012) [E3]
2012Hsu A, Parsons KS, Barr I, Hansbro PM, Wark PA, 'Deficient antiviral responses to influenza in primary bronchial epithelial cells of chronic obstructive pulmonary disease', Respirology, Canberra, ACT (2012) [E3]
2012Addnan FH, Wood LG, Garg ML, Wark PA, 'Antiviral effects of antioxidants on human rhinovirus', Respirology, Canberra, ACT (2012) [E3]

Co-authors: Lisa Wood, Manohar Garg

2012Wark PA, Tooze MK, Hsu A, Parsons KS, 'Silencing of MDA5 and TLR3 does not reduce innate immune responses to rhinovirus in defective asthmatic bronchial epithelial cells', Respirology, Canberra, ACT (2012) [E3]

Co-authors: Alan Hsu

2012Wark PA, Tooze MK, Cheese L, Whitehead BF, Gibson PG, McDonald VM, 'Viral infections trigger CF exacerbations and worsen infection with P Aeruginosa in adults and children', Respirology, Canberra, ACT (2012) [E3]
2012See HV, Simpson JL, Hansbro PM, Wark PA, 'Stable COPD patients have less rhinovirus-induced intracellular innate cytokines detected in PBMCS compared to healthy adults', Respirology, Canberra, ACT (2012) [E3]
2012Patel S, McKay K, Cooper P, Sorrell T, Andresen D, Middleton P, et al., 'Fungal colonisation and clinical associations in children with cystic fibrosis', Mycoses, Berlin, Germany (2012) [E3]
2012Zhong H, Simpson JL, Wood LG, Wark PA, 'Different responses of blood neutrophils from COPD', Respirology, Hong Kong (2012) [E3]
2012Zhong H, Simpson JL, Wood LG, Wark PA, 'Activation of human neutrophils exposed to cigarette smoke extract: A comparison of COPD patients versus healthy non-smokers', Respirology, Canberra, ACT (2012) [E3]
2011Wark PA, Parsons KS, Tooze MK, Hsu A, 'MDA5 is crucial inhibiting rhinovirus replication in primary bronchial epithelial cells', Respirology, Perth, WA (2011) [E3]

Co-authors: Alan Hsu

2011Bozinovski S, Uddin M, Vlahos R, Thompson M, Merritt A-S, Wark PA, et al., 'Serum amyloid A augments mucosal immunity by opposing resolving Lipoxina4 signaling in chronic lung disease', American Journal of Respiratory and Critical Care Medicine, Denver, CO (2011) [E3]
2011Parsons KS, Tooze MK, Hsu A, Wark PA, 'Oxidative stress induces mitochondrial dusfunction in airway epithelial cells and impairs response to rhinovirus', Respirology, Perth, WA (2011) [E3]

Co-authors: Alan Hsu

2011Sukkar MB, Wood LG, Tooze MK, Simpson JL, McDonald VM, Gibson PG, Wark PA, 'Deficiency of srage in asthma and COPD is selectively associated with neutrophilic airway inflammation', American Journal of Respiratory and Critical Care Medicine, Denver, CO (2011) [E3]
2011Addnan FH, Wark PA, Wood LG, Garg ML, 'Effects of antioxidants on inflammation and apoptosis in rhinovirus-infected airway epithelial cells', Australasian Medical Journal, Queenstown, NZ (2011) [E3]

Co-authors: Lisa Wood, Manohar Garg

2011Smart JM, Wark PA, Wood LG, 'Investigating the obesity paradox in ex-smokers', Australasian Medical Journal, Queenstown, NZ (2011) [E3]

Co-authors: Lisa Wood

2011Zhong H, Tooze MK, Wood LG, Simpson JL, Wark PA, 'Effect of cigarette smoke extract on neutrophils isolated from human peripheral blood', Respirology, Perth, WA (2011) [E3]
2011Hatchwell LM, Collison AM, Pereira De Siqueira AL, Foster PS, Verrills NM, Don A, et al., 'A novel E3 ubiquitin ligase links rhinovirus infection to exacerbation of asthma', Respirology, Perth, WA (2011) [E3]
2011Vanders RL, Gibson PG, Murphy VE, Wark PA, 'Reduced antiviral interferons during pregnancy explains susceptibility to influenza virus infection', Respirology, Perth, WA (2011) [E3]
2011See HV, Simpson JL, Hansbro PM, Wark PA, 'COPD patients PBMCS have an impaired immune response to phinovirus-infected bronchial epithelium', Respirology, Perth, WA (2011) [E3]
2011Baines KJ, Tooze MK, Wark PA, 'Rhinovirus infected airway epithelial cells have an increased pro-inflammatory response in COPD', Respirology, Perth, WA (2011) [E3]

Co-authors: Katherine Baines

2011Addnan FH, Wark PA, Wood LG, Garg ML, 'Antiviral activity of antioxidants against rhinovirus infection', Australasian Medical Journal, Queenstown, NZ (2011) [E3]

Co-authors: Lisa Wood, Manohar Garg

2011Sukkar M, Wood LG, Tooze MK, Simpson JL, McDonald VM, Gibson PG, Wark PA, 'Soluble RAGE is deficient in neutrophilic asthma and COPD', Respirology, Perth, WA (2011) [E3]
2011Ryan NM, Vertigan AE, Ferguson JK, Wark PA, Gibson PG, 'Investigation and characterization of persistent cough associated with H1N1 2009 influenza', Respirology, Perth, WA (2011) [E3]
2010Pretto JJ, McDonald VM, Wark PA, Hensley MJ, 'An audit of clinical practice for COPD hospital admissions', Respirology, Brisbane, QLD (2010) [E3]
2010Vanders RL, Gibson PG, Murphy VE, Wark PA, 'Reduced anti-viral responses: Why pregnant women have increased susceptibility to respiratory virus infection', American Journal of Respiratory and Critical Care Medicine, New Orleans, LO (2010) [E3]
2010McDonald VM, Pretto JJ, Wark PA, Hensley MJ, 'Low acuity COPD admissions: Are they avoidable?', Respirology, Brisbane, QLD (2010) [E3]
2010Smart JM, Wark PA, McDonald VM, Wood LG, 'Low levels of body fat and obstructive airway disease in ex-smokers', Proceedings of the Nutrition Society of Australia, Perth (2010) [E3]
2010Smart JM, Wark PA, McDonald VM, Wood LG, 'Body composition in ex-smokers with and without airflow obstruction', Obesity Research and Clinical Practice, Sydney, NSW (2010) [E3]
2010Gangireddy SR, Parsons KS, Tooze MK, Wark PA, 'The innate immune response to rhinovirus in bronchial epithelial cells is predominately controlled by signalling initiated via MDA-5', Respirology, Brisbane, QLD (2010) [E3]
2010Vanders RL, Gibson PG, Murphy VE, Wark PA, 'Reduced anti-viral responses: Why pregnant women have increased susceptiblty to respiratory virus infection', Respirology, Brisbane, QLD (2010) [E3]
2010Parsons KS, Tooze MK, Gangireddy SR, Wark PA, 'Cigarette smoke extract impairs epithelial cell antiviral response to rhinovirus infection', Respirology, Brisbane, QLD (2010) [E3]
2010Pretto JJ, McDonald VM, Wark PA, Hensley MJ, 'An audit of clinical practice for COPD hospital admissions to eight Australian public hospitals', European Respiratory Society Annual Congress 2010. Abstracts, Barcelona, Spain (2010) [E3]
2010Yan X, He S, Gangireddy SR, Gibson PG, Wark PA, 'Monocyte derived dendritic cells from COPD patients and their therapeutic potential', Respirology, Brisbane, QLD (2010) [E3]

Co-authors: Peter Gibson

2010Smart JM, Wark PA, McDonald VM, Wood LG, 'CRP, body composition and lung function in ex-smokers', Respirology, Brisbane, QLD (2010) [E3]
2009Foo A, Lam CE, Wark PA, Foster PS, Phipps S, 'Immune mechanisms that promote the development of inducible bronchus-associated lymphoid tissue (iBALT)', American Journal of Respiratory and Critical Care Medicine, San Diego, CA (2009) [E3]

Co-authors: Paul Foster

2009Parsons KS, Gangireddy SR, Hansbro PM, Barr I, Wark PA, 'Response of primary bronchial epithelial cells to infection with human influenza virus', Respirology, Darwin, NT (2009) [E3]
2009Wark PA, See HV, Simpson JL, Vanders RL, Hansbro PM, 'Peripheral blood monocytes (PBMCs) display innate antiviral response to rhinovirus (RV) infected bronchial epithelial cells', Journal of Immunology, Seattle, WASH. (2009) [E3]
2009Wark PA, Hsu A, Hansbro PM, 'Innate immune response of bronchial epithelial cells to infection with influenza', Journal of Immunology, Seattle, WASH. (2009) [E3]
2009Southern KW, Smyth A, Wark PA, Ryan G, Dwan K, Yates N, et al., 'The impact of Cochrane systematic reviews on cyctic fibrosis care', Pediatric Pulmonology, Minneapolis (2009) [E3]
2009Wark PA, Oldham RA, Brooks C, Simpson JL, Douwes J, 'Airway neutrophilia in chronic obstructive pulmonary disease (COPD) and asthma are associated with lower lung function and the presence of pathogenic bacteria', Respirology, Darwin, NT (2009) [E3]
2009Baines KJ, Grissell TV, Gibson PG, Wark PA, 'Molecular mechanisms of rhinovirus infection of primary bronchial epithelial cells', Respirology, Darwin, NT (2009) [E3]
2009Wark PA, Parsons KS, Ryan J, Grissell T, Bell N, Chapman JN, Gibson PG, 'Seasonal patterns (2004-2007) of respiratory viruses isolated with acute airways disease', Respirology, Darwin, NT (2009) [E3]
2009Clarke J, Cookson K, Gendle L, Bentley L, Wark PA, McDonald VM, 'Evaluation of patient acceptance of CF segregation and isolation policies', Respirology, Darwin, NT (2009) [E3]
2009Addnan FH, Wood LG, Garg ML, Wark PA, 'Resveratrol prevents hydrogen peroxide induced cytotoxicity', Proceedings of the Nutrition Society of Australia, Newcastle, NSW (2009) [E3]

Co-authors: Lisa Wood, Manohar Garg

2009Twaddell S, Loewenthal MR, Gibson PG, Saltos N, Wark PA, 'Individualised aminoglycoside dosing in adult patients with cystic fibrosis improves pharmacokinetic parameters', Respirology, Darwin, NT (2009) [E3]
2009Hsu A, Hansbro PM, Barr I, Wark PA, 'Innate immune response of bronchial epithelial cells to human and avian influenza virus', Respirology, Darwin, NT (2009) [E3]
2008Osei-Kumah A, Wark PA, Smith R, Ammit A, Clifton VL, 'A model of pregnancy induced changes in asthma', 51st Annual Scientific Meeting of the Endocrine Society of Australia and Society of Reproductive Biology: Meeting Proceedings and Abstract Book, Melbourne, VIC (2008) [E3]
2008Wark PA, Davies BL, Parsons KS, Grissell T, 'Impaired release of inflammatory mediators from COPD bronchial epithelial cells (BECs) in response to rhinovirus (RV) and lipopolysaccharide (LPS)', Respirology, Melbourne, VIC (2008) [E3]
2008Wark PA, Oldham RA, Simpson JL, Douwes J, 'Endotoxin levels are higher in the bronchoalveolar lavage of ex-smokers compared to never smokers', Respirology, Melbourne, VIC (2008) [E3]
2008Oliver BGG, Kuo C, Johnston SL, King NJC, Wark PA, Lim S, et al., 'Rhinovirus infection of primary human airway smooth muscle cells and fibroblasts induces extracellular matrix deposition', American Journal of Respiratory and Critical Care Medicine, Toronto, ONT (2008) [E3]
2008Hsu A, Grissell TV, Wark PA, 'Distribution of SAa2,6GAL and SAa2,3GAL linked receptors in human respiratory tract and influenza virus replication', Respirology, Melbourne, VIC (2008) [E3]
2008Hsu A, Hansbro PM, Wark PA, 'Innate immune response of bronchial epithelial cells to human and avian influenza virus', The 4th Congress of the Federation of Immunology Societies of Asia-Oceania: Conference Program, Taipei, Taiwan (2008) [E3]
2007Jenkins CR, Marks GB, Gibson PG, Wark PA, Thien FCK, Belousova EG, et al., 'A randomised controlled trial of two algorithms for maintaining asthma control on long acting bronchodilators (LABA) and inhaled corticosteroids (ICS)', Respirology (TSANZ Abstracts-Posters), Auckland (2007) [E3]

Co-authors: Peter Gibson

2007Wark PA, See HV, Oldham R, Timmins N, Gibson PG, Hansbro PM, 'Response by peripheral blood monocytes (PBMCs) to rhinovirus (RV) is greater in cells exposed to infected epithelium in coculture than exposed to RV alone', American Journal of Respiratory and Critical Care Medicine (American Thoracic Society 2007 International Conference Abstracts), San Francisco (2007) [E3]
2007Reddel HK, Peters MJ, Wark PA, Sand IB, Jenkins CR, 'Comparison of the efficacy of seretide and flixotide when down-titrating the inhaled corticosteroid dose', American Journal of Respiratory and Critical Care Medicine (American Thoracic Society 2007 International Conference Abstracts), San Francisco (2007) [E3]
2007Grissell TV, Hansbro NG, Hsu A, Mimica J, Wark PA, 'Response of primary bronchoepithelial cells from COPD, asthmatic and healthy subjects to infection with avian and human influenza virus strains', Respirology (Abstracts of the 12th Congress of the Asian Pacific Society of Respirology), Gold Coast, QLD (2007) [E3]

Co-authors: Nicole Hansbro

2007See H, Oldham R, Timmins N, Hansbro PM, Wark PA, Gibson PG, 'Rhinovirus (RV) induced inflammatory response in mononuclear cells is enhanced by coculture with airway epithelium', Respirology (TSANZ Abstracts-Posters), Auckland (2007) [E3]
2007Xatzipsalti M, Haynes R, Ribbene A, Sones JL, Bagmane D, Wark PA, et al., 'Deficient interferon production following rhinovirus infection of differentiated bronchial epithelial cells from asthmatic subjects', American Journal of Respiratory and Critical Care Medicine (American Thoracic Society 2007 International Conference Abstracts), San Francisco (2007) [E3]
2007Ribbene A, Bucchieri F, Wark PA, Andrews AL, Puddicombe SM, Zummo G, et al., 'Epithelial-mesenchymal communication following rhinovirus infection of asthmatic bronchial epithelial cells', American Journal of Respiratory and Critical Care Medicine (American Thoracic Society 2007 International Conference Abstracts), San Francisco (2007) [E3]
2007Saedi Some Olia A, Garg ML, Wood LG, Gibson PG, Wark PA, 'Anti-inflammatory effect of lycopene enrichment on infected cultured airway epithelial cells', Respirology (Abstracts of the 12th Congress of the Asian Pacific Society of Respirology), Gold Coast, QLD (2007) [E3]
2007De Groot RS, Kuo C, King N, Moir L, Lim S, Burgess JK, et al., 'Steroids can reverse rhinovirus-induced alterations to bronchial epithhelium extracellular matrix deposition', Respirology (Abstracts of the 12th Congress of the Asian Pacific Society of Respirology), Gold Coast, QLD (2007) [E3]
2007Wark PA, Mimica J, Oldham R, Davies DE, Holgate SE, Johnston S, Gibson PG, 'Interferon-G induced protein (IP)- 10 is a novel clinical biomarker of rhinovirus (RV)-induced asthma exacerbations', Respirology (TSANZ Abstracts-Posters), Auckland (2007) [E3]

Co-authors: Peter Gibson

2007Wark PA, Grissell TV, Davies B, Mimica J, Oldham R, Shafren DR, Gibson PG, 'Bronchial epithelial cell (BEC) response to clinical rhinovirus (clin-RV) isolates from ASTHMATICS compared to laboratory (lab-RV) strains', American Journal of Respiratory and Critical Care Medicine (American Thoracic Society 2007 International Conference Abstracts), San Francisco (2007) [E3]
2007Saedi Some Olia A, Garg ML, Wood LG, Wark PA, Gibson PG, 'Lycopene enrichment of cultured epithelial airway cells', Asia Pacific Journal of Clinical Nutrition, Auckland, New Zealand (2007) [E3]
2006Grissell TV, Davies B, Mimica JL, Shafren DR, Gibson PG, Wark PA, 'Bronchial epithelial cell response to clinical rhinoviruses isolated from asthmatics compared to laboratory rhinovirus strains', Respirology, Canberra (2006) [E3]
2006Wark PA, Wood LG, Grissell TV, Davies B, Shafren DR, Powell HG, et al., 'Acute virus-induced asthma is characterised by increased expression of toll-like receptors (TLR)-2', Respirology, Canberra (2006) [E3]
2004Wark PAB, Johnston SL, Bucchieri F, Powell R, Puddicombe S, Laza-Stanca V, et al., 'Asthmatic bronchial epithelial cells have deficient innate immune response to infection with rhinovirus', THORAX, London, ENGLAND (2004)
2003Wark PAB, Bucchieri F, Puddicombe SM, Andrews AL, Johnston SL, Davies DE, Holgate ST, 'Cytotoxic effects of infection with rhinovirus on asthmatic primary bronchial epithelial cells', EUROPEAN RESPIRATORY JOURNAL, TAORMINA, ITALY (2003)
2003Wark PAB, Buccheri F, Puddicombe S, Johnston SJ, Holgate ST, Davies DE, 'Asthmatic bronchial epithelial cells (BEC) are more resistant to early apoptosis induced by rhinovirus (RV) and this is associated with increased viral replication', THORAX, LONDON, ENGLAND (2003)
2002Wark PAB, Puddicombe SM, Frew AJ, Holgate ST, Davies DE, 'Determinants of cytotoxicity of residual oil fly ash (ROFA) on bronchial epithelial cells', THORAX, LONDON, ENGLAND (2002)
Show 70 more

Creative Work (1 outputs)

YearCitationAltmetricsLink
2011McDonald VM, Wark PA, Gibson PG, Alison J, Spencer L, Wood LG, Roberts M, Living with COPD: Chronic Obstructive Pulmonary Disease, The Australian Lung Foundation, Newcastle (2011) [J2]
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Grants and Funding

Summary

Number of grants41
Total funding$7,250,972

- Indicates that the researcher may be seeking students for this project.

Click on a grant title below to expand the full details for that specific grant.

2014 (3 grants)

Toll-like receptor 7 and asthma $673,712
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Joerg Mattes, Professor Paul Foster, Conjoint Professor Peter Wark
SchemeRole
Project GrantInvestigator
Total AmountFunding StartFunding Finish
$673,71220142016
GNo:G1300093

Mechanisms of dysregulated antiviral signallings to influenza infection in chronic obstructive pulmonary disease$27,512
Funding Body: John Hunter Hospital Charitable Trust Fund

Project Team
Doctor Alan Hsu, Doctor Fatemeh Moheimani, Professor Darryl Knight, Conjoint Professor Peter Wark
SchemeRole
Research GrantInvestigator
Total AmountFunding StartFunding Finish
$27,51220142014
GNo:G1400435

Immunosenescence in chronic obstructive pulmonary disease leads to abnormal innate immune responses to human rhinovirus infection$20,000
Funding Body: Hunter Medical Research Institute

Project Team
Conjoint Professor Peter Wark, Professor Darryl Knight
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$20,00020142014
GNo:G1301331

2013 (5 grants)

Inflammometry in Stable COPD; A Randomised Controlled Trial (RCT)$717,071
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Conjoint Professor Peter Gibson, Associate Professor Vanessa McDonald, Associate Professor Jodie Simpson, Conjoint Professor Peter Wark
SchemeRole
Project GrantInvestigator
Total AmountFunding StartFunding Finish
$717,07120132016
GNo:G1200185

Enhancing innate immune responses to influenza in chronic obstructive pulmonary disease$504,552
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Conjoint Professor Peter Wark, Professor Phil Hansbro, Professor James Mahony
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$504,55220132015
GNo:G1200206

BD FACSCanto II Violet Laser (405nm) upgrade including Trigon and 2 photomultiplier tubes (PMTs)$25,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Conjoint Professor Peter Wark, Doctor Alan Hsu, Doctor Katie Baines, Associate Professor Jodie Simpson, Conjoint Professor Peter Gibson, Ms Hayley See
SchemeRole
Equipment GrantChief Investigator
Total AmountFunding StartFunding Finish
$25,00020132013
GNo:G1201180

Protecting Pregnant Women from Death during influenza epidemics$25,000
Funding Body: Hunter Medical Research Institute

Project Team
Professor Roger Smith, Professor Phil Hansbro, Conjoint Professor Peter Wark
SchemeRole
Project GrantInvestigator
Total AmountFunding StartFunding Finish
$25,00020132013
GNo:G1301181

Mechanisms of impaired antiviral interferon response to influenza infection in primary bronchial epithelial cells from chronic obstructive pulmonary disease$23,810
Funding Body: John Hunter Hospital Charitable Trust Fund

Project Team
Doctor Alan Hsu, Conjoint Professor Peter Wark
SchemeRole
Research GrantInvestigator
Total AmountFunding StartFunding Finish
$23,81020132013
GNo:G1300711

2012 (1 grants)

Body plethysmograph respiratory function system$33,076
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Conjoint Professor Peter Gibson, Conjoint Professor Peter Wark, Associate Professor Lisa Wood, Associate Professor Jodie Simpson, Doctor Katie Baines, Doctor Vanessa Murphy, Doctor Jeffrey Pretto, Emeritus Professor Michael Hensley, Ms Jenny Mackney
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$33,07620122012
GNo:G1100973

2011 (7 grants)

Identifying new therapeutic targets for preventing the induction and progression of COPD$626,732
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Phil Hansbro, Conjoint Professor Peter Wark
SchemeRole
Project GrantInvestigator
Total AmountFunding StartFunding Finish
$626,73220112013
GNo:G1000252

Role of Placental Retroviral Protein Syncytin Carried on Exosomes in Mediating Vulnerability of Pregnant Women to Influenza$622,968
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Roger Smith, Conjoint Professor Peter Wark
SchemeRole
Project GrantInvestigator
Total AmountFunding StartFunding Finish
$622,96820112013
GNo:G1000294

Understanding the mechanisms of respiratory viral infection- and COPD-induced predisposition to secondary bacterial pneumonia $573,390
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Phil Hansbro, Conjoint Professor Peter Wark
SchemeRole
Project GrantInvestigator
Total AmountFunding StartFunding Finish
$573,39020112013
GNo:G1000248

Research microscope, confocal ready nikon eclipse 90i microscope$69,157
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Roger Smith, Conjoint Professor Tam Zakar, Associate Professor Jon Hirst, Doctor Kaushik Maiti, Doctor Gemma Madsen, Professor Rodney Scott, Conjoint Professor Peter Wark, Professor Paul Foster, Professor Phil Hansbro, Conjoint Professor Ian Wright
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$69,15720112011
GNo:G1100024

SCIREQ FlexiVentFX system + FlexiVentFX extension$45,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Phil Hansbro, Professor Paul Foster, Professor Joerg Mattes, Doctor Simon Keely, Doctor Jay Horvat, Doctor Nicole Hansbro, Doctor Ming Yang, Doctor Catherine Ptaschinski, Doctor Kelly Asquith, Doctor Gough Au, Conjoint Professor Peter Wark, Laureate Professor John Aitken, Conjoint Professor Keith Jones, Professor Roger Smith, Professor Judith Black, Professor Rakesh Kumar, Professor Paul Hertzog
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$45,00020112011
GNo:G1100037

To determine if asthmatics and children at risk of asthma that develop acute exacerbations have defective antiviral innate immune responses$28,000
Funding Body: John Hunter Hospital Charitable Trust Fund

Project Team
Conjoint Professor Peter Wark, Doctor Larry Roddick, Associate Professor Lisa Wood
SchemeRole
Research GrantChief Investigator
Total AmountFunding StartFunding Finish
$28,00020112011
GNo:G1100177

Lung Function (Spirometry) testing and sputum induction equipment - establishing 3 new clinical workstations. Medgraphics CPFS/d USB spirometer with breezesuite software (x3). Laptop computer (x3). Ul$10,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Conjoint Professor Peter Gibson, Associate Professor Jodie Simpson, Associate Professor Lisa Wood, Doctor Katie Baines, Conjoint Professor Peter Wark, Doctor Vanessa Murphy
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$10,00020112011
GNo:G1100038

2010 (2 grants)

Real time PCR machine (Mastercycler ep realplex2 from Epprndorf) $34,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Associate Professor Jodie Simpson, Conjoint Professor Peter Gibson, Conjoint Professor Peter Wark, Associate Professor Lisa Wood, Doctor Vanessa Murphy, Doctor Robert Scott, Doctor Katie Baines
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$34,00020102010
GNo:G1000056

Identifying novel biomarkers of oxidative stress in chronic obstructive pulmonary disease$25,000
Funding Body: Hunter Children`s Research Foundation

Project Team
Conjoint Professor Peter Wark, Associate Professor Lisa Wood
SchemeRole
Research GrantChief Investigator
Total AmountFunding StartFunding Finish
$25,00020102010
GNo:G0900145

2009 (3 grants)

394591 ELx405UV select plate washer and workstation integration kit$27,500
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Conjoint Professor Peter Gibson, Doctor Xiao Yan He, Associate Professor Jodie Simpson, Associate Professor Lisa Wood, Conjoint Professor Peter Wark
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$27,50020092009
GNo:G0189853

Development of novel therapeutic approaches for rhinovirus - induced asthma exacerbation$24,500
Funding Body: Hunter Medical Research Institute

Project Team
Professor Joerg Mattes, Professor Paul Foster, Conjoint Professor Peter Wark
SchemeRole
Project GrantInvestigator
Total AmountFunding StartFunding Finish
$24,50020092009
GNo:G0189800

Treatment of subjects with cystic fibrosis who are colonised with aspergillus fumigatus$20,000
Funding Body: University of Newcastle

Project Team
Conjoint Professor Peter Wark, Associate Professor Scott Bell, Associate Professor Peter Bye, Associate Professor Adam Jaffe, Dr Hiran Selvadurai, Professor Phillip Robinson
SchemeRole
Near Miss GrantChief Investigator
Total AmountFunding StartFunding Finish
$20,00020092009
GNo:G0189818

2008 (6 grants)

Inflammatory mechanisms of airways disease$845,000
Funding Body: Hunter Medical Research Institute

Project Team
Conjoint Professor Peter Wark
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$845,00020082013
GNo:G0189566

The mechanisms of infection of bronchial epithelial cells by human & avian influenza viruses in chronic airways disease$379,650
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Conjoint Professor Peter Wark, Professor Phil Hansbro, Dr Ian Barr
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$379,65020082010
GNo:G0187593

The use of the components of the bacteria, streptococcus pneumoniae, as novel immunotherapies for asthma$50,000
Funding Body: Asthma Foundation of New South Wales

Project Team
Professor Phil Hansbro, Professor Rakesh Kumar, Conjoint Professor Peter Wark
SchemeRole
Research GrantInvestigator
Total AmountFunding StartFunding Finish
$50,00020082008
GNo:G0188434

Mechanisms of inflammatory airways disease$40,571
Funding Body: Markey Insurance

Project Team
Conjoint Professor Peter Wark
SchemeRole
HMRI GrantChief Investigator
Total AmountFunding StartFunding Finish
$40,57120082008
GNo:G0189370

Becton Dickinson high throughout sampler for the FACSCanto II cytometry system$35,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Conjoint Professor Peter Wark, Conjoint Professor Peter Gibson, Associate Professor Jodie Simpson, Associate Professor Lisa Wood, Doctor Vanessa Murphy, Professor Phil Hansbro
SchemeRole
Equipment GrantChief Investigator
Total AmountFunding StartFunding Finish
$35,00020082008
GNo:G0188547

PP2A: A new target for asthma therapy$20,000
Funding Body: University of Newcastle

Project Team
Professor Alistair Sim, Doctor Nikki Verrills, Professor John Scott, Conjoint Professor Peter Wark
SchemeRole
Near Miss GrantInvestigator
Total AmountFunding StartFunding Finish
$20,00020082008
GNo:G0188395

2007 (8 grants)

Chronic Exposure of Bronchial Epithelial Cells to Bacterial Components Modifies their Innate Immune Response to Infection with Respiratory Viruses$313,500
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Conjoint Professor Peter Wark
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$313,50020072009
GNo:G0186439

In vitro response of bronchial epithelial cells and activation of lymphocytes to infection with rhinovirus$58,848
Funding Body: John Hunter Hospital Charitable Trust Fund

Project Team
Conjoint Professor Peter Wark, Professor Phil Hansbro, Associate Professor Jodie Simpson
SchemeRole
Research GrantChief Investigator
Total AmountFunding StartFunding Finish
$58,84820072009
GNo:G0188095

Differential regulation of human mast cell degranulation by discrete forms of protein phosphatase 2A$50,000
Funding Body: Asthma Foundation of New South Wales

Project Team
Professor Alistair Sim, Doctor Nikki Verrills, Professor Paul Foster, Conjoint Professor Peter Wark, Conjoint Professor Peter Gibson, Dr Gregory Kranias
SchemeRole
Research GrantInvestigator
Total AmountFunding StartFunding Finish
$50,00020072007
GNo:G0187247

Nitric Oxide Monitoring System (NIOX)$45,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Conjoint Professor Peter Gibson, Conjoint Associate Professor Vicki Clifton, Conjoint Professor Warwick Giles, Emeritus Professor Michael Hensley, Doctor Vanessa Murphy, Conjoint Professor Peter Wark, Associate Professor Vanessa McDonald, Associate Professor Jodie Simpson, Conjoint Associate Professor Bruce Whitehead, Professor Paul Foster, Professor Phil Hansbro, Associate Professor Lisa Wood
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$45,00020072007
GNo:G0188193

In vitro response of bronchial epithelial cells and activation of lymphocytes from COPD patients by infection with rhinovirus, respiratory syncytial virus and haemophilus influenza$25,000
Funding Body: GlaxoSmithKline Australia

Project Team
Conjoint Professor Peter Wark, Professor Phil Hansbro, Associate Professor Jodie Simpson
SchemeRole
Support GrantChief Investigator
Total AmountFunding StartFunding Finish
$25,00020072008
GNo:G0188309

Class II biohazard containment hood and carbon dioxide cell culture incubator$20,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Conjoint Professor Peter Wark, Conjoint Professor Peter Gibson, Associate Professor Jodie Simpson, Doctor Vanessa Murphy, Associate Professor Lisa Wood, Professor Paul Foster, Professor Phil Hansbro
SchemeRole
Equipment GrantChief Investigator
Total AmountFunding StartFunding Finish
$20,00020072007
GNo:G0188192

Hewlett Packard 7890 series gas chromatograph with accessories$20,000
Funding Body: NHMRC (National Health & Medical Research Council)

Miccroarrays to identify novel therapeutic targets for bird flu$14,500
Funding Body: John Hunter Hospital Charitable Trust Fund

Project Team
Conjoint Professor Peter Wark, Professor Phil Hansbro
SchemeRole
Research GrantChief Investigator
Total AmountFunding StartFunding Finish
$14,50020072007
GNo:G0187337

2006 (4 grants)

PRC Priority Research Centre for Asthma & Respiratory Diseases$524,282
Funding Body: University of Newcastle

Project Team
Professor Paul Foster, Conjoint Professor Peter Gibson, Conjoint Professor Kenneth Beagley, Emeritus Professor Michael Hensley, Professor Phil Hansbro, Professor Joerg Mattes, Professor Alistair Sim, Conjoint Professor Peter Wark
SchemeRole
Priority Research CentreInvestigator
Total AmountFunding StartFunding Finish
$524,28220062013
GNo:G0186914

Surveillance and Analysis of Avian Influenza Viruses in Migratory Birds in Australia$249,625
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Phil Hansbro, Dr Ian Barr, Conjoint Professor Peter Wark, Dr Paul Selleck, Dr Simone Warner, Professor Paul Foster, Dr Aeron Hurt, Dr Irene Peroulis, Dr John Curran, Conjoint Professor Peter Gibson
SchemeRole
Potential Avian Influenza-Induced PandemicInvestigator
Total AmountFunding StartFunding Finish
$249,62520062006
GNo:G0186000

The interaction between airway epithelial cells infected with rhinovirus and lymphocytes from subjects with COPD$15,000
Funding Body: Hunter Medical Research Institute

Project Team
Conjoint Professor Peter Wark
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$15,00020062006
GNo:G0186106

Equipment - Microscope$5,000
Funding Body: Hunter Medical Research Institute

Project Team
Conjoint Professor Peter Wark
SchemeRole
PULSE Early Career Researcher of the Year AwardChief Investigator
Total AmountFunding StartFunding Finish
$5,00020062006
GNo:G0186168

2001 (1 grants)

Mechanisms of bronchial epithelial cell activation in rhinovirus infection in asthma, COAD and normal airways$338,516
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Conjoint Professor Peter Wark
SchemeRole
Training (Postdoctoral) Fellowships - Neil Hamilton Fairley Clinical Fellowship (Overseas)Chief Investigator
Total AmountFunding StartFunding Finish
$338,51620012005
GNo:G0180753

1998 (1 grants)

The investigation of airway inflammation and cell death in acute severe asthma$45,500
Funding Body: Asthma Foundation of New South Wales

Project Team
Conjoint Professor Peter Gibson, Conjoint Professor Peter Wark
SchemeRole
Research GrantInvestigator
Total AmountFunding StartFunding Finish
$45,50019981999
GNo:G0177660
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Research Supervision

Number of current supervisions8
Total current UoN Masters EFTSL0.1
Total current UoN PhD EFTSL1.95

For supervisions undertaken at an institution other that the University of Newcastle, the institution name is listed below the program name.

Current Supervision

CommencedProposed
Completion
ProgramSupervisor TypeResearch Title
20142018PhD (Immunology & Microbiol)Co-SupervisorChronic Obstructive Pulmonary Disease (COPD)
20132015M Philosophy (Immun & Microbi)Co-SupervisorRole of Innate Immune Cells in the Pathogenesis of COPD
20132017PhD (Medicine)Principal SupervisorThe Role of the PI3K Signalling Pathway in the Innate Antiviral Responses
20132017PhD (Immunology & Microbiol)Co-SupervisorInvestigation of the pathogenesis and potential therapeutic interventions of influenza in Asthma and COPD
20112015PhD (Medicine)Principal SupervisorImpaired Innate Immune Responses in Asthmatics
20102015PhD (Immunology & Microbiol)Co-SupervisorIndentification of New Therapeutics in COPD/ Emphysema
20092013PhD (Immunology & Microbiol)Co-SupervisorMechanisms of Increased Susceptibility to Influenza Infection in Chronic Airways Disease Mouse Models
20072012PhD (Medicine)Principal SupervisorCharacterising Innate Immune Responses and the Role of PD-1 in Patients with COPD

Past Supervision

YearProgramSupervisor TypeResearch Title
2014PhD (Medical Biochemistry)Co-SupervisorRole of Antioxidants in Rhinovirus-Infected Airway Epithelial Cells
2013M Philosophy (Medicine)Co-SupervisorAn Investigation of Body Composition in People With and Without Chronic Obstructive Pulmonary Disease (COPD)
2013PhD (Medicine)Co-SupervisorInvestigation of the Immune Mechanisms in Pregnancy and Asthma Leading to Increased Susceptibility and Disease Severity to Respiratory Virus Infections
2011PhD (Immunology & Microbiol)Co-SupervisorImmune Mechanisms that Promote the Development of Inducible Bronchus-Associated Lymphoid Tissue (IBALT)
2010PhD (Medicine)Principal SupervisorMechanism of Infection of Bronchial Epithelial Cells by Human and Avian Influenza Viruses
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Conjoint Professor Peter Wark

Work Phone(02) 40420110
Fax(02) 4985 5850
Email
PositionConjoint Professor
Centre for Asthma and Respiratory Disease
School of Medicine and Public Health
Faculty of Health and Medicine
The University of Newcastle, Australia
Focus AreaImmunology and Microbiology
Office
2107,
Level 2, West HMRI building,
Lot 1 Kookaburra Close New Lambton
URL:www.newcastle.edu.au/profile/peter-wark