Staff Profile
Career Summary
Biography
My research career has focused on the gram positive bacterium Bacillus subtilis. During my PhD I purified and characterised the replication terminator protein (RTP) and its DNA binding sites (Lewis et al., J. Bacteriol 171, 3564-3567 (1989); Lewis et al., J. Mol. Biol. 214, 73-84 (1990)). These sites are regions of DNA where oppositely moving replication forks meet and newly replicated chromosomes are resolved prior to segregation. During my post-doctoral research I was responsible for the development of cell biological techniques and vectors for visualising gene expression and protein localisation in live bacterial cells (Lewis et al., PNAS 91, 3849-3853 (1994); Lewis et al., Mol Microbiol 13, 655-662 (1994); Lewis and Errington, Microbiology 142, 733-740 (1996); Lewis and Marston, Gene 227, 101-109 (1999); Feucht and Lewis, Gene 264, 289-297 (2001)). These techniques have been widely adopted by research groups involved in microbial cell biology, and the plasmid vectors have now been distributed directly to well over 100 laboratories world-wide, although they are now also distributed by the Bacillus Genetic Stock Centre. These techniques were instrumental in determining the establishment of compartment specificity of developmentally regulated s-factors during sporulation in B. subtilis (Lewis et al., PNAS 91, 3849-3853 (1994)). I also showed that prespore specific accumulation of the transcription regulator SpoIIAA was responsible for initiation of compartment-specific gene expression during development, that this accumulation was probably due to prespore-specific activity of the phosphatase SpoIIE, and that a programme of proteolysis was initiated following this activation event (Lewis et al., Genes Cell 1, 881-894 (1996); Lewis et al., J. Bacteriol 180, 3276-3284 (1998)). I was also involved in work that showed that the highly conserved SpoIIIE (FtsK) protein is a DNA translocase that moves DNA through a division septum (Wu et al., Genes Dev 9, 1316-1326 (1995)). This was the first example of such a phenomenon, and was a very significant finding as previously it was assumed that DNA was segregated into daughter cells/different compartments prior to division septum formation. Finally, I have shown that transcription and translation are spatially separated within bacteria (Lewis et al., EMBO J 19, 710-718 (2000)). This was an unexpected result as the 2 processes were thought to be very tightly coupled in bacteria. Furthermore, transcription becomes concentrated into a sub-fraction of the bacterial nucleoid at higher growth rates. These transcription foci have been shown to be the sites of rRNA synthesis, and my laboratory is now focussing on characterising transcription complexes and their structure in detail.
Qualifications
- Doctor of Philosophy, University of Sydney, 14/06/1991
- Bachelor of Science, University of Sheffield - UK, 19/07/1986
Research
Research keywords
- Microscopy
- Molecular Microbiology
- Transcription regulation
Research expertise
My research career has focused on the gram positive bacterium Bacillus subtilis. During my PhD I purified and characterised the replication terminator protein (RTP) and its DNA binding sites (Lewis et al., J. Bacteriol 171, 3564-3567 (1989); Lewis et al., J. Mol. Biol. 214, 73-84 (1990)). These sites are regions of DNA where oppositely moving replication forks meet and newly replicated chromosomes are resolved prior to segregation. During my post-doctoral research I was responsible for the development of cell biological techniques and vectors for visualising gene expression and protein localisation in live bacterial cells (Lewis et al., PNAS 91, 3849-3853 (1994); Lewis et al., Mol Microbiol 13, 655-662 (1994); Lewis and Errington, Microbiology 142, 733-740 (1996); Lewis and Marston, Gene 227, 101-109 (1999); Feucht and Lewis, Gene 264, 289-297 (2001)). These techniques have been widely adopted by research groups involved in microbial cell biology, and the plasmid vectors have now been distributed directly to well over 100 laboratories world-wide, although they are now also distributed by the Bacillus Genetic Stock Centre. These techniques were instrumental in determining the establishment of compartment specificity of developmentally regulated s-factors during sporulation in B. subtilis (Lewis et al., PNAS 91, 3849-3853 (1994)). I also showed that prespore specific accumulation of the transcription regulator SpoIIAA was responsible for initiation of compartment-specific gene expression during development, that this accumulation was probably due to prespore-specific activity of the phosphatase SpoIIE, and that a programme of proteolysis was initiated following this activation event (Lewis et al., Genes Cell 1, 881-894 (1996); Lewis et al., J. Bacteriol 180, 3276-3284 (1998)). I was also involved in work that showed that the highly conserved SpoIIIE (FtsK) protein is a DNA translocase that moves DNA through a division septum (Wu et al., Genes Dev 9, 1316-1326 (1995)). This was the first example of such a phenomenon, and was a very significant finding as previously it was assumed that DNA was segregated into daughter cells/different compartments prior to division septum formation. Finally, I have shown that transcription and translation are spatially separated within bacteria (Lewis et al., EMBO J 19, 710-718 (2000)). This was an unexpected result as the 2 processes were thought to be very tightly coupled in bacteria. Furthermore, transcription becomes concentrated into a sub-fraction of the bacterial nucleoid at higher growth rates. These transcription foci have been shown to be the sites of rRNA synthesis, and my laboratory is now focussing on characterising transcription complexes and their structure in detail.
Fields of Research
| Code | Description | Percentage |
|---|---|---|
| 060199 | Biochemistry And Cell Biology Not Elsewhere Classified | 50 |
| 110800 | Medical Microbiology | 35 |
| 060499 | Genetics Not Elsewhere Classified | 15 |
Memberships
ARC Committee member
- OzReader - Biological Sciences
Body relevant to professional practice.
- Member of EU 6th Framework Consortium for A$20M EU 6th framework BaSysBio project - European Union (EU) Framework Collaboration
Appointments
| National Convener Molecular Microbiology Special Interest Group Australian Society for Microbiology (Australia) | 01/07/2005 |
Awards
Research Award.
| 2004 | International Short-Term Fellowship Australian Academy of Sciences (Australia) Provided funds for short term fellowship in lab of Dr Philippe Noirot, Jouy-en-Josas, France to perform a genomic yeast 2-hybrid screen of proteins that interact with RNA polymerase. This fellowship laid the foundation for the subsequent BaSysBio EU 6th framework application and placed me as a central figure in the establishment of the consortium. |
|---|
Invitations
| Invited speaker Conference, United Kingdom (Conference Presentation - non published.) | 2007 |
| Reviewer Various Publishers in the field of Environmental and Life Science, Australia (Invitation to review submitted papers to top academic journals in the field) | 2007 |
Administrative
Administrative expertise
No expertise.
Teaching
Teaching keywords
- Molecular Biology
Teaching expertise
Molecular biology, particularly bacterial. Microbiology.
Grants and Funding
Summary
| Number of grants | 42 |
|---|---|
| Total funding | $26,028,577 |
For project grants received where the lead institution is other than the University of Newcastle, details are shown in italics.
Click on a grant title below to expand the full details for that specific grant.
2013 (2 grants)
Characterisation of a macromolecular complex essential for rapid microbial cell proliferation$20,000
Funding Body: Hunter Medical Research Institute
| Project Team | ||
|---|---|---|
| Professor Peter Lewis | ||
| Scheme | Role | |
| Near Miss | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $20,000 | 2013 | 2013 |
| GNo:G1300698 | ||
Characterisation of a macromolecular complex essential for rapid microbial cell proliferation$20,000
Funding Body: University of Newcastle
| Project Team | ||
|---|---|---|
| Professor Peter Lewis, Doctor Xiao Yang | ||
| Scheme | Role | |
| Near Miss Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $20,000 | 2013 | 2013 |
| GNo:G1300482 | ||
2012 (2 grants)
Targeting nucleic acid synthesis and cell division in gram-negative bacterial pathogens$311,439
Funding Body: NHMRC (National Health & Medical Research Council)
| Project Team | ||
|---|---|---|
| Professor Nicholas Dixon, Associate Professor Elizabeth Harry, Professor Peter Lewis, Associate Professor Aaron Oakley, Doctor Ian Grainge | ||
| Scheme | Role | |
| Project Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $311,439 | 2012 | 2014 |
| GNo:G1101133 | ||
Ultrasonic Homogenizer System and -80 ºC Freezers for chemical and biological sample storage$10,000
Funding Body: NHMRC (National Health & Medical Research Council)
| Project Team | ||
|---|---|---|
| Professor Adam McCluskey, Professor Eileen McLaughlin, Professor Peter Lewis, Ms Belinda Nixon, Doctor Shaun Roman, Doctor Jennette Sakoff, Doctor Ian Grainge | ||
| Scheme | Role | |
| Equipment Grant | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $10,000 | 2012 | 2012 |
| GNo:G1100986 | ||
2011 (6 grants)
Exploitation of bacterial transcription initiation as a target for new antimicrobials$521,706
Funding Body: NHMRC (National Health & Medical Research Council)
| Project Team | ||
|---|---|---|
| Professor Peter Lewis, Associate Professor Renate Griffith, Associate Professor Naresh Kumar | ||
| Scheme | Role | |
| Project Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $521,706 | 2011 | 2013 |
| GNo:G1000285 | ||
Establishment of a comprehensive regional biophysical analysis facility
$500,000
Funding Body: ARC (Australian Research Council)
| Project Team | ||
|---|---|---|
| Professor Peter Lewis, Professor Nicholas Dixon, Professor Eileen McLaughlin, Professor Adam McCluskey, Associate Professor Aaron Oakley, Professor Paul Foster, Laureate Professor John Aitken, Associate Professor Jennifer Beck, Dr Michael Kelso, Professor Graham Nicholson, Associate Professor Elizabeth Harry, Professor Ian Charles, Associate Professor Steven Djordjevic | ||
| Scheme | Role | |
| Linkage Infrastructure Equipment & Facilities (LIEF) | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $500,000 | 2011 | 2011 |
| GNo:G1000630 | ||
Chemical Biology$444,961
Funding Body: University of Newcastle
| Project Team | ||
|---|---|---|
| Professor Adam McCluskey, Doctor Warwick Belcher, Doctor Ian Grainge, Professor Christopher Grof, Professor Peter Lewis, Professor Eileen McLaughlin, Doctor Shaun Roman, Conjoint Professor Ray Rose, Doctor Jennette Sakoff, Doctor Nikki Verrills | ||
| Scheme | Role | |
| Priority Research Centre | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $444,961 | 2011 | 2015 |
| GNo:G1100052 | ||
Structure function analysis of the NusA-RNA polymerase interaction$300,000
Funding Body: ARC (Australian Research Council)
| Project Team | ||
|---|---|---|
| Professor Peter Lewis, Doctor Xiao Yang, Dr Richard Lewis, Dr Jon Marles-Wright | ||
| Scheme | Role | |
| Discovery Projects | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $300,000 | 2011 | 2013 |
| GNo:G1000129 | ||
Establishment of a comprehensive regional biophysical analysis facility
$230,000
Funding Body: ARC (Australian Research Council)
| Project Team | ||
|---|---|---|
| Professor Peter Lewis, Professor Nicholas Dixon, Professor Eileen McLaughlin, Professor Adam McCluskey, Associate Professor Aaron Oakley, Professor Paul Foster, Laureate Professor John Aitken, Associate Professor Jennifer Beck, Dr Michael Kelso, Professor Graham Nicholson, Associate Professor Elizabeth Harry, Professor Ian Charles, Associate Professor Steven Djordjevic | ||
| Scheme | Role | |
| Linkage Infrastructure Equipment & Facilities (LIEF) Partner funding | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $230,000 | 2011 | 2011 |
| GNo:G1100484 | ||
Eppendorf mastercycler pro with thermomixer comfort and 5430R centrifuge$15,000
Funding Body: NHMRC (National Health & Medical Research Council)
| Project Team | ||
|---|---|---|
| Professor Eileen McLaughlin, Professor Peter Lewis, Professor Adam McCluskey, Conjoint Professor Keith Jones, Associate Professor Brett Nixon, Doctor Shaun Roman, Doctor Jennette Sakoff, Doctor Ian Grainge, Doctor Janet Holt, Doctor Xiao Yang | ||
| Scheme | Role | |
| Equipment Grant | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $15,000 | 2011 | 2011 |
| GNo:G1100028 | ||
2009 (3 grants)
An Advanced Mass Spectrometry Facility for Applications in Proteomics and Organic Chemistry$495,000
Funding Body: ARC (Australian Research Council)
| Project Team | ||
|---|---|---|
| Laureate Professor John Aitken, Professor Adam McCluskey, Doctor Mark Baker, Doctor Nikki Verrills, Professor Marcel Maeder, Doctor Xiaojing Zhou, Professor Eileen McLaughlin, Associate Professor Brett Nixon, Doctor Shaun Roman, Conjoint Professor Ray Rose, Professor Hugh Dunstan, Professor Christopher Grof, Professor Roger Smith, Conjoint Professor Peter Gibson, Conjoint Professor Alison Jones, Professor Mike Calford, Conjoint Professor Keith Jones, Doctor Rick Thorne, Emeritus Professor Peter Dunkley, Professor Paul Foster, Conjoint Professor Leonie Ashman, Professor Gordon Burns, Associate Professor Phillip Dickson, Professor John Rostas, Professor Rodney Scott, Associate Professor Paul Tooney, Professor Phil Hansbro, Professor Pablo Moscato, Professor Paul Dastoor, Professor Peter Lewis | ||
| Scheme | Role | |
| Linkage Infrastructure Equipment & Facilities (LIEF) | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $495,000 | 2009 | 2009 |
| GNo:G0189122 | ||
An Advanced Mass Spectrometry Facility for Applications in Proteomics and Organic Chemistry$50,000
Funding Body: ARC (Australian Research Council)
| Project Team | ||
|---|---|---|
| Laureate Professor John Aitken, Professor Adam McCluskey, Doctor Mark Baker, Doctor Nikki Verrills, Professor Marcel Maeder, Doctor Xiaojing Zhou, Professor Eileen McLaughlin, Associate Professor Brett Nixon, Doctor Shaun Roman, Conjoint Professor Ray Rose, Professor Hugh Dunstan, Professor Christopher Grof, Professor Roger Smith, Conjoint Professor Peter Gibson, Conjoint Professor Alison Jones, Professor Mike Calford, Conjoint Professor Keith Jones, Doctor Rick Thorne, Emeritus Professor Peter Dunkley, Professor Paul Foster, Conjoint Professor Leonie Ashman, Professor Gordon Burns, Associate Professor Phillip Dickson, Professor John Rostas, Professor Rodney Scott, Associate Professor Paul Tooney, Professor Phil Hansbro, Professor Pablo Moscato, Professor Paul Dastoor, Professor Peter Lewis | ||
| Scheme | Role | |
| Linkage Infrastructure Equipment & Facilities (LIEF) Partner funding | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $50,000 | 2009 | 2009 |
| GNo:G0189948 | ||
LAS-4000 Chemiluminescence imaging system$25,000
Funding Body: NHMRC (National Health & Medical Research Council)
| Project Team | ||
|---|---|---|
| Professor Eileen McLaughlin, Laureate Professor John Aitken, Professor Peter Lewis, Associate Professor Brett Nixon, Doctor Shaun Roman | ||
| Scheme | Role | |
| Equipment Grant | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $25,000 | 2009 | 2009 |
| GNo:G0189852 | ||
2008 (2 grants)
X-ray crystallography resource for membrane proteins and large macromolecular complexes$93,000
Funding Body: ARC (Australian Research Council)
| Project Team | ||
|---|---|---|
| Professor Peter Lewis, Doctor Robyn Malby | ||
| Scheme | Role | |
| Linkage Infrastructure Equipment & Facilities (LIEF) | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $93,000 | 2008 | 2008 |
| GNo:G0188894 | ||
Structural Analysis of Bacterial Transcription Proteins by X-ray Crystallography$14,600
Funding Body: University of Newcastle
| Project Team | ||
|---|---|---|
| Doctor Robyn Malby, Professor Peter Lewis | ||
| Scheme | Role | |
| Pilot Grant | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $14,600 | 2008 | 2008 |
| GNo:G0189075 | ||
2007 (7 grants)
Nucleic Acid Synthesis and Cell Division in Model Pathogenic Bacteria$740,250
Funding Body: NHMRC (National Health & Medical Research Council)
| Project Team | ||
|---|---|---|
| Professor Peter Lewis, Professor Nicholas Dixon, Associate Professor Elizabeth Harry | ||
| Scheme | Role | |
| Project Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $740,250 | 2007 | 2009 |
| GNo:G0186390 | ||
Towards an understanding of dynamic genetic regulation at global scale in bacteria: A systems biology approach$486,000
Funding Body: NHMRC (National Health & Medical Research Council)
| Project Team | ||
|---|---|---|
| Professor Peter Lewis | ||
| Scheme | Role | |
| NHMRC ‐ European Union Collaborative Research Grants | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $486,000 | 2007 | 2009 |
| GNo:G0186507 | ||
Towards an understanding of dynamic transcriptional regulation at a global scale in bacteria: a system biology approach$110,250
Funding Body: Department of Innovation, Industry, Science and Research
| Project Team | ||
|---|---|---|
| Professor Peter Lewis | ||
| Scheme | Role | |
| International Science Linkages (ISL) Program | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $110,250 | 2007 | 2009 |
| GNo:G0187015 | ||
RNA POLYMERASE PROTEIN INTERACTIONS AND THE REGULATION OF TRANSCRIPTION ELONGATION$16,900
Funding Body: University of Newcastle
| Project Team | ||
|---|---|---|
| Professor Peter Lewis | ||
| Scheme | Role | |
| Near Miss Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $16,900 | 2007 | 2007 |
| GNo:G0187186 | ||
Hamamatsu ORCA-AG cooled CCD camera$12,000
Funding Body: NHMRC (National Health & Medical Research Council)
| Project Team | ||
|---|---|---|
| Professor Peter Lewis | ||
| Scheme | Role | |
| Equipment Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $12,000 | 2007 | 2007 |
| GNo:G0188190 | ||
4th Conference on Functional Genomics of Gram-Positive Microorganisms, Green Park Resort, Tirrenia, Italy, 24/6/2007 - 28/6/2007$2,500
Funding Body: University of Newcastle
| Project Team | ||
|---|---|---|
| Professor Peter Lewis | ||
| Scheme | Role | |
| Travel Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $2,500 | 2007 | 2007 |
| GNo:G0187783 | ||
Towards an understanding of dynamic transcriptional regulation at global scale in bacteria: a systems biology approach. BaSysBio$1
Funding Body: European Commission, European Union
| Project Team | ||
|---|---|---|
| Professor Peter Lewis | ||
| Scheme | Role | |
| Sixth Framework Programme | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $1 | 2007 | 2007 |
| GNo:G0186876 | ||
2006 (2 grants)
Towards and understanding of dynamic genetic regulation at a global scale in bacteria: a Systems biology approach$20,000,000
Funding Body: European Commission, European Union
| Scheme | Role | |
|---|---|---|
| 6th Framework | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $20,000,000 | 2006 | 2007 |
| GNo:17800412 | ||
Structural analysis and functional inactivation of bacterial transcription complexes$273,000
Funding Body: ARC (Australian Research Council)
| Project Team | ||
|---|---|---|
| Professor Peter Lewis, Conjoint Associate Professor Renate Griffith, Dr Richard Lewis | ||
| Scheme | Role | |
| Discovery Projects | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $273,000 | 2006 | 2008 |
| GNo:G0185244 | ||
2005 (5 grants)
High throughput proteomics - Thermo Finnigan ProteomeX LCQ Integrated Proteomicis Workstation$207,189
Funding Body: ARC (Australian Research Council)
| Project Team | ||
|---|---|---|
| Laureate Professor John Aitken, Professor Eileen McLaughlin, Professor Peter Lewis, Conjoint Associate Professor Renate Griffith, Conjoint Professor Ray Rose, Emeritus Professor John Patrick, Associate Professor David McCurdy, Professor Adam McCluskey, Emeritus Professor Ellak Von Nagy-Felsobuki, Emeritus Professor Peter Dunkley, Associate Professor Phillip Dickson, Professor John Rostas, Conjoint Professor Leonie Ashman, Professor Gordon Burns, Professor Paul Foster, Conjoint Professor Peter Gibson, Professor Roger Smith, Professor Alistair Sim, Associate Professor Paul Tooney, Dr Fraser Ross | ||
| Scheme | Role | |
| Linkage Infrastructure Equipment & Facilities (LIEF) | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $207,189 | 2005 | 2005 |
| GNo:G0184185 | ||
Structural analysis of bacillus subtilis RNA polymerase elongation complexes$25,064
Funding Body: ARC (Australian Research Council)
| Project Team | ||
|---|---|---|
| Professor Peter Lewis, Dr Richard Lewis, Assoc. Prof Alasdair McDowall | ||
| Scheme | Role | |
| Linkage International Award | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $25,064 | 2005 | 2007 |
| GNo:G0184314 | ||
2005 RIBG allocation$20,811
Funding Body: University of Newcastle
| Project Team | ||
|---|---|---|
| Professor Peter Lewis | ||
| Scheme | Role | |
| Research Infrastructure Block Grant (RIBG) | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $20,811 | 2005 | 2005 |
| GNo:G0185832 | ||
Structural Analysis and Functional Inactivation of Bacillus Subtilis RNA Polymerase$13,000
Funding Body: University of Newcastle
| Project Team | ||
|---|---|---|
| Professor Peter Lewis, Conjoint Associate Professor Renate Griffith | ||
| Scheme | Role | |
| Project Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $13,000 | 2005 | 2005 |
| GNo:G0184652 | ||
Development of genetically engineered systems to monitor the bioavailability of pollutants in soil and water samples$8,000
Funding Body: University of Newcastle
| Project Team | ||
|---|---|---|
| Professor Peter Lewis | ||
| Scheme | Role | |
| Project Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $8,000 | 2005 | 2005 |
| GNo:G0184651 | ||
2004 (4 grants)
Multifunctional confocal laser scanning microscope with time resolved and two photon imaging and fluorescence correlation capabilities$579,000
Funding Body: Australian Research Council
| Scheme | Role | |
|---|---|---|
| Linkage Infrastructure Equipment & Facilities (LIEF) | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $579,000 | 2004 | 2004 |
| GNo:17800237 | ||
In vivo studies on the regulation of transcription and translation in Bacillus subtilis$210,000
Funding Body: ARC (Australian Research Council)
| Project Team | ||
|---|---|---|
| Professor Peter Lewis | ||
| Scheme | Role | |
| Discovery Projects | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $210,000 | 2004 | 2006 |
| GNo:G0182839 | ||
Investigation of transcript factor interaction with RNA polymerase in Bacillus subtilis$6,000
Funding Body: University of Newcastle
| Project Team | ||
|---|---|---|
| Professor Peter Lewis, Conjoint Associate Professor Renate Griffith | ||
| Scheme | Role | |
| Project Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $6,000 | 2004 | 2004 |
| GNo:G0183378 | ||
ASM 2004 Sydney, 26 Sept - 1 Oct 2004$450
Funding Body: University of Newcastle
| Project Team | ||
|---|---|---|
| Professor Peter Lewis | ||
| Scheme | Role | |
| Travel Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $450 | 2004 | 2004 |
| GNo:G0184930 | ||
2003 (2 grants)
Protein-protein interactions in Bacillus subtilis.$8,500
Funding Body: University of Newcastle
| Project Team | ||
|---|---|---|
| Professor Peter Lewis, Conjoint Associate Professor Renate Griffith | ||
| Scheme | Role | |
| Project Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $8,500 | 2003 | 2003 |
| GNo:G0182487 | ||
International Conference of Functional Genomics of Gram-positive Microorganisms, Baveno, Italy 22-28 June, 2003$2,400
Funding Body: University of Newcastle
| Project Team | ||
|---|---|---|
| Professor Peter Lewis | ||
| Scheme | Role | |
| Travel Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $2,400 | 2003 | 2003 |
| GNo:G0183093 | ||
2002 (3 grants)
Investigation of Protein-Protein Interactions in Bacillus subtillis$10,000
Funding Body: University of Newcastle
| Project Team | ||
|---|---|---|
| Professor Peter Lewis, Conjoint Associate Professor Renate Griffith | ||
| Scheme | Role | |
| Project Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $10,000 | 2002 | 2002 |
| GNo:G0181282 | ||
Subcellular localisation of translation factors in Bacillus subtillis$5,000
Funding Body: University of Newcastle
| Project Team | ||
|---|---|---|
| Professor Peter Lewis | ||
| Scheme | Role | |
| Project Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $5,000 | 2002 | 2002 |
| GNo:G0181368 | ||
Prokaryotic Development Canada, 10-14 July, 2002$2,400
Funding Body: University of Newcastle
| Project Team | ||
|---|---|---|
| Professor Peter Lewis | ||
| Scheme | Role | |
| Travel Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $2,400 | 2002 | 2002 |
| GNo:G0182003 | ||
2001 (3 grants)
Characterisation of transcription foci, their role in chromosome segregation, and the localisation of transcription and translation factors in Bacillus subtilis$211,350
Funding Body: ARC (Australian Research Council)
| Project Team | ||
|---|---|---|
| Professor Peter Lewis | ||
| Scheme | Role | |
| Large Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $211,350 | 2001 | 2003 |
| GNo:G0179272 | ||
Subcellular localisation of energy generating enzymes in the bacterium Bacillus subtilis.$12,000
Funding Body: University of Newcastle
| Project Team | ||
|---|---|---|
| Professor Peter Lewis | ||
| Scheme | Role | |
| Project Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $12,000 | 2001 | 2001 |
| GNo:G0179953 | ||
ComBio 2001 National Convention Centres, Canberra 1-4 October, 2001$806
Funding Body: University of Newcastle
| Project Team | ||
|---|---|---|
| Professor Peter Lewis | ||
| Scheme | Role | |
| Travel Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $806 | 2001 | 2001 |
| GNo:G0181575 | ||
2000 (1 grants)
High resolution microscopic studies on the internal organisation of the bacterium Bacillus subtilis.$15,000
Funding Body: University of Newcastle
| Project Team | ||
|---|---|---|
| Professor Peter Lewis | ||
| Scheme | Role | |
| New Staff Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $15,000 | 2000 | 2000 |
| GNo:G0179918 | ||
Research Supervision
| Number of current supervisions | 6 |
|---|---|
| Total current UoN PhD EFTSL | 2.5 |
For supervisions undertaken at an institution other that the University of Newcastle, details are shown in italics, and the institution name is listed below the program name.
Current Supervision
| Commenced | Proposed Completion | Program | Supervisor Type | Research Title |
|---|---|---|---|---|
| 2013 | 2017 | PhD (Biological Sciences) | Co-Supervisor | Isolation, Purification and Crystallisation of the Major Proteins Involved in the Later Stages of Prokaryotic Chromosome Segregation and Cell Division |
| 2013 | 2017 | PhD (Biological Sciences) | Co-Supervisor | Replication Fork Stalling and Recovery in Escherichia Coli |
| 2012 | 2016 | PhD (Biological Sciences) | Principal Supervisor | Bacterial Transcription Factors NusB, NusE ATFA and p as Targets for Antibiotic Research |
| 2012 | 2016 | PhD (Biological Sciences) | Co-Supervisor | Development of Genetic Tools for the Quantitative Assessment of Gene Depletion in Pathogenic Bacteria |
| 2010 | 2014 | PhD (Biological Sciences) | Principal Supervisor | Structural Characterisation of Bacterial Protein Factors That Bind RNA Polymerase |
| 2006 | 2009 | PHD Microbiology University of Newcastle | Sole Supervisor | Structural analysis of RNA polymerase |
Past Supervision
| Year | Program | Supervisor Type | Research Title |
|---|---|---|---|
| 2013 | PhD (Biological Sciences) | Principal Supervisor | Investigation of the Transcription Complex in Acinetobacter baylyi ADP1 and the Identification of the Novel Small Acidic Transcription Factor AtfA |
| 2013 | PhD (Biological Sciences) | Co-Supervisor | Genetic Regulation of Embryo Development and Formation of Seed Storage Products in the Legume Model Medicago truncatula |
| 2012 | PhD (Biological Sciences) | Sole Supervisor | The Characterisation of the Interaction between PcrA and RNA Polymerase |
| 2011 | PhD (Biological Sciences) | Principal Supervisor | The RNA Polymerase-Q Interaction as a Target for Potential Novel Antimicrobials |
| 2010 | PhD (Biological Sciences) | Sole Supervisor | The Structure of Bacterial RNA Polymerase in Complex With the Essential Transcription Elongation Factor NusA |
| 2008 | PhD (Biological Sciences) | Sole Supervisor | The Composition of Transcription Complexes in Bacillus Subtilis |
| 2007 | Honours Microbiology University of Newcastle | Sole Supervisor | Interaction of C-terminus of PcrA with the B subunit of RNA polymerase |
| 2007 | Honours Microbiology University of Newcastle | Sole Supervisor | Characterisation of the interaction between PcrA and the B-subunit of RNA polymerase |
| 2006 | Honours Microbiology University of Newcastle | Sole Supervisor | Interaction of transcription factors NusB and NusE in Bacillus subtilis |
| 2006 | Honours Microbiology University of Newcastle | Sole Supervisor | Characterisation of the interaction between PcrA and the beta subunit of RNA polymerase |
| 2006 | Honours Microbiology University of Newcastle | Sole Supervisor | The design and testing of inhibitors of interactions between essential transcription factors and RNA polymerase |
| 2005 | Honours Microbiology University of Newcastle | Sole Supervisor | Development of an engineered Bacillus subtilis strain for the detection of bioavailable environmental toxicants |
| 2004 | Honours Microbiology University of Newcastle | Sole Supervisor | Interactions between RNA polymerase and transcription factors: An integrated approach |
| 2004 | Honours Microbiology University of Newcastle | Sole Supervisor | Analysis of translation initiation factors in Bacillus subtilis |
| 2004 | Honours Microbiology University of Newcastle | Sole Supervisor | Analysis of translation elongation factors EF-Tu and EF-G in Bacillus subtilis |
| 2004 | Honours Microbiology University of Newcastle | Sole Supervisor | Subcellular localisation of the transcription elongation factors NusB, NusG and GreA in Bacillus subtilis |
| 2002 | Honours Microbiology University of Newcastle | Sole Supervisor | Subcellular localisation of tranlsation factors in Bacillus subtilis |
| 2002 | Honours Microbiology University of Newcastle | Sole Supervisor | Subcellular localisation of NusA in Bacillus subtilis |
| 2002 | Honours Microbiology University of Newcastle | Sole Supervisor | Subcellular localisation of ATP synthase in Bacillus subtilis |
Professor Peter Lewis
| Work Phone | (02) 4921 5701 |
|---|---|
| Fax | (02) 4921 5472 |
| Peter.Lewis@newcastle.edu.au | |
| Position | Professor School of Environmental and Life Sciences Faculty of Science and Information Technology |
| Focus Area | Biological Sciences |
| Office | BG10, Biological Sciences, Callaghan University Drive Callaghan NSW 2308 Australia |
| URL: | www.newcastle.edu.au/profile/peter-lewis |
