Profile Image

Conjoint Professor Peter Gibson

Conjoint Professor

School of Medicine and Public Health

Joining forces to ease the wheeze

Australia's two million sufferers of airway disease can breathe easier thanks to the work of the University's groundbreaking respiratory researchers.

Conjoint Professor Peter GibsonFrom the bench to the bedside, the University of Newcastle's Centre for Asthma and Respiratory Diseases is leading the way in the understanding, management and treatment of chronic airway conditions.

Centre co-directors Professor Paul Foster and Professor Peter Gibson lead highly talented teams of scientists and doctors who integrate the latest advances in laboratory technology and methodology with innovative, patient-focused research.

The work of the centre is internationally recognised, having contributed significantly to advancing both medical practice and policy through its discoveries.

Its studies are regularly published in the most prestigious journals and it is a major training hub for respiratory medicine and immunology, attracting gifted PhD students and postdoctoral researchers from around the world to work and study in Newcastle.

Foster and Gibson's teams work under the umbrella of the Hunter Medical Research Institute, a partnership between the University of Newcastle and Hunter New England Health. They also collaborate with research groups in Sydney, Newcastle, Melbourne and Perth as part of the Cooperative Research Centre for Asthma and Airways, a $55 million government-backed program.

Gibson is working at the clinical interface, using his role as a respiratory physician at the John Hunter Hospital in Newcastle to inform his research into treatments and management strategies for asthma and airway disease.

Foster, the University's Chair in Immunology, investigates the molecular and cellular mechanisms of disease in the laboratory. Both have a keen interest in unravelling the critical role of inflammation in asthma and other respiratory conditions.

"We are constantly on the lookout for better treatments but with a disease like asthma, management is also important," Gibson says.

"For some people, just understanding what is happening to them is enough to make a big difference to their condition and quality of life."

Gibson's clinically based team is involved in research projects with significant implications for future treatment and management of airway disease (see below).

Novel discoveries have also been made by the centre's laboratory-based researchers.  These discoveries have enhanced the understanding of processes associated with the development and progression of respiratory diseases.

Centre scientists study the cellular and molecular functions of the diseases on animal models then collaborate with the clinical researchers to validate their findings using human tissue.

Foster says the centre is at the forefront of interpreting how inflammation, which underpins airway disease, occurs and of developing new anti-inflammatory treatments.

A major breakthrough was their research into how microRNA molecules, which regulate protein production in human cells, can cause inflammation in the body that can manifest as asthma. Working out how to control that inflammatory response has provided scientists with a therapeutic target, which could lead to new treatments.

"Steroids are the conventional treatment, but they can have side effects and while they dampen response, they do not cure the disease," Foster explains.

"Also, not everyone is responsive to steroids and within that non-responsive group there is a lot of morbidity."

Foster says his team has made a significant contribution to the understanding of the mechanisms of steroid-resistant inflammatory pathways that may be relevant to asthma, bringing them closer to the goal of developing alternative treatments. Other critical areas of laboratory research focus on allergies, viruses and infection as triggers for asthma.

While the two arms of research within the centre are undertaken by different teams, Foster says it is the critical mass that contributes to its overall success.

"What we have is diversity and common interest," he says. "There are similar centres of excellence around the world but they primarily do either clinical-based research or basic immunology. The way the two are integrated here is what makes us unique and underpins our success."

"People are willing to collaborate," Gibson agrees, "and it is only by linking patient-focused research with laboratory discoveries and evidence-based medicine that we are able to get these broad insights into disease."

Leading the wayProfessor Paul Foster and Professor Peter Gibson talking

Professor Peter Gibson's clinical research team is leading three groundbreaking projects that could revolutionise the treatment of asthma.

These specific projects involve better management of asthma in pregnancy, the development of a blood test to diagnose the disease and the treatment of non-eosinophilic asthma with macrolide antibiotics.

The team's study into asthma in pregnancy was prompted by the reluctance of women to use treatments during gestation, even though severe asthmatic episodes can be harmful to both mother and child.

As part of this project, researchers measured nitric oxide, which is produced by inflamed airways, in the pregnant patient's exhaled breath. They were then able to adjust the amount of medication according to the severity of the inflammation.

In many cases this reduced the amount of steroid that needed to be administered, which made women more likely to take their medication as they were less apprehensive about the treatment and its effects on their unborn child.

Another benefit was that the frequency of asthma exacerbations, or episodes, decreased because the condition was being better managed.

In another study, published this year in the American Journal of Respiratory and Critical Care Medicine, the team used the emerging scientific field of proteomics (the study of proteins) to identify four blood-based biomarkers that when analysed together can distinguish between asthma and chronic obstructive pulmonary disease.

The two diseases share common symptoms, so are difficult to distinguish, but require different therapeutic approaches.

This finding could lead to the development of the first blood test for asthma, which would be a major diagnostic breakthrough.

The third project is the AMAZES study (Asthma and Macrolides: Azithromycin Efficacy and Safety). It will trial an alternative treatment, known as a macrolide antibiotic, for asthma that is not responsive to conventional steroid medication.

Steroids treat a particular cell, called an eosinophil, which is thought to provoke inflammation when present in increased levels. But research has established that up to half of adults with asthma symptoms have normal levels of eosinophils and respond poorly to conventional treatment.

The five-year, $2.9 million study is trialling the antibiotic on approximately 400 asthmatics in four cities and is the biggest study into non-eosinophilic asthma in the world.  It is funded by the National Health and Medical Research Council.

Visit the Centre for Asthma and Respiratory Diseases website

Visit the HMRI website

Joining forces to ease the wheeze

Joining forces to ease the wheeze

The School of Medicine and Public Health is a multi-disciplinary team of researchers, many of whom are recognised as world-leaders in their field.

Read more

Career Summary

Biography

Peter Gibson works as a doctor who cares for people with respiratory diseases and as a clinical scientist investigating the mechanisms and treatment of asthma, Chronic Obstructive Pulmonary Disease (COPD), cough, and other airway disorders.

He is a concept leader who has developed innovative approaches around inflammatory subtypes of asthma and cough; airway biomarkers; neurogenic mechanisms, laryngeal dysfunction and related treatments for refractory cough; multidimensional assessment and management of complex airway disorders such as severe asthma, airways diseases in the elderly, and asthma in pregnant women.

Peter's research metrics record a H index of 62 (Scopus 2015), 450 published articles, competitive research funding success, and effective mentorship of clinical researchers.  His peers have awarded Peter several research medals and elected him as the president of the Thoracic Society of Australia and New Zealand (2015-6).

His research, clinical practice, and participation in guideline panels serve to bring research developments into focus as effective health care interventions that improve the health of people suffering from breathing disorders.

Research Expertise
Inflammation and immunological mechanism of airway diseases such as asthma, COPD, and cough. Clinical assessment and treatment of airway diseases. Practice guidelines and policy of respiratory diseases.



Qualifications

  • Bachelor of Medicine & Surgery, University of New South Wales

Keywords

  • Asthma
  • COPD
  • Cough

Fields of Research

CodeDescriptionPercentage
110799Immunology not elsewhere classified20
110299Cardiorespiratory Medicine and Haematology not elsewhere classified80

Professional Experience

Academic appointment

DatesTitleOrganisation / Department
1/01/2009 - 1/12/2013Fellow NHMRC
NHMRC - Practitioner Fellowships (Formerly Practioner Fellowships Scheme)
National Health & Medical Research Council
1/01/2004 - 1/12/2008Fellowship
NHMRC - Practitioner Fellowships (Formerly Practioner Fellowships Scheme)
National Health & Medical Research Council
Edit

Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Book (4 outputs)

YearCitationAltmetricsLink
2005Gibson P, Abramson M, Wood-Baker R, Volmink J, Hensley M, Costabel U, Evidence-Based Respiratory Medicine, BMJ Books/Blackwell Pub, Malden, Mass., 608 (2005)
2005Gibson PG, Monitoring Asthma, Taylor & Francis, Boca Raton, 576 (2005)
2005Gibson P, Abramson M, Wood-Baker R, Volmink J, Hensley M, Costabel U, Evidence-Based Respiratory Medicine, BMJ Books/Blackwell Pub, Malden, Mass., 608 (2005)
2005Gibson PG, Monitoring Asthma, Taylor & Francis, Boca Raton, 576 (2005)
Show 1 more book

Chapter (16 outputs)

YearCitationAltmetricsLink
2014McDonald VM, Gibson PG, 'Asthma Education', Clinical Asthma, CRC Press, Bosa Roca/US 127-137 (2014) [B2]
DOI10.1201/b16468-18
Co-authorsVanessa Mcdonald
2013Scott H, Wood LG, Garg ML, Gibson PG, 'Asthma and Inflammation', Nutrition and Physical activity in inflammatory diseases, CABI, Oxford, UK 299-321 (2013) [B1]
Co-authorsLisa Wood, Manohar Garg, Hayley Scott
2011Gaga M, Zervas E, Gibson PG, 'Allergic and nonallergic factors in severe asthma', Difficult-to-Treat Severe Asthma, European Respiratory Society, Sheffield, UK 107-119 (2011) [B1]
DOI10.1183/1025448x.10001210
2011Gibson PG, Wang F, He XY, Brightling CE, 'Noninvasive assessment of inflammation in severe asthma', Difficult-to-Treat Severe Asthma, European Respiratory Society, Sheffield, UK 208-217 (2011) [B1]
DOI10.1183/1025448x.10002110
2010Murphy VE, Gibson PG, 'Asthma and rhinitis in pregnancy', Allergy Frontiers: Therapy and Prevention, Springer, Berlin 485-497 (2010) [B1]
Co-authorsVanessa Murphy
2010Wark PA, Gibson PG, 'Pathogenesis of ABPA', Aspergillosis: From diagnosis to prevention, Springer, Berlin 695-706 (2010) [B1]
Co-authorsPeter Wark
2009Simpson JL, Baines KJ, Gibson PG, 'Biology of neutrophils', Middleton's Allergy: Principles & Practice, Mosby, Philadelphia, Pennsylvania 283-294 (2009) [B1]
Co-authorsKatherine Baines, Jodie Simpson
2009Murphy VE, Gibson PG, 'Asthma in pregnancy', Pulmonary Problems in Pregnancy, Humana Press, New York 143-164 (2009) [B1]
DOI10.1007/978-1-59745-445-2
Co-authorsVanessa Murphy
2009McDonald VM, Gibson PG, 'Asthma patient education', Allergy Frontiers: Diagnosis and Health Economics, Springer, Berlin 475-489 (2009) [B1]
DOI10.1007/978-4-431-98349-1_26
Co-authorsVanessa Mcdonald
2008Gibson PG, 'Clinical assessment of asthma', Clinical Asthma, Mosby, Maryland Heights, Missouri 119-126 (2008) [B1]
DOI10.1016/b978-032304289-5.10013-x
2007Powell H, Gibson PG, 'Role of self-management in preventing asthma exacerbations', Exacerbations of Asthma, Informa Healthcare, London, United Kingdom 307-320 (2007) [B1]
2007Wood LG, Gibson PG, Garg ML, 'Alpha-tocopherol and cystic fibrosis', The Encyclopedia of Vitamin E, Centre for Agricultural Bioscience International, Wallingford, United Kingdom 708-718 (2007) [B1]
Co-authorsLisa Wood, Manohar Garg
2001Gibson PG, Yates D, Saltos N, 'Examination of Sputum, Nasal Cytology and Exhaled Gases', Manual of Asthma Management, WB Saunders Company Ltd, London 107-118 (2001) [B1]
2001Gibson PG, Boulet L-P, 'ROLE OF ASTHMA EDUCATION', Evidence-Based Asthma Management, B.C. Decker Inc., Hamilton, Ontario, Canada 275-290 (2001) [B2]
2001Gibson PG, Simpson J, 'Measurement of Cytokines in Induced Sputum', Interleukin Protocols, Humana Press, Totowa, New Jersey 305-312 (2001) [B1]
2000Gibson PG, Wilson A, 'Quality of life in asthma', Understanding asthma: a management companion, MacLennan & Petty Pty Limited, Sydney Australia 278-288 (2000) [B1]
Show 13 more chapters

Journal article (399 outputs)

YearCitationAltmetricsLink
2015Vanders RL, Murphy VE, Gibson PG, Hansbro PM, Wark PAB, 'CD8 T cells and dendritic cells: Key players in the attenuated maternal immune response to influenza infection', Journal of Reproductive Immunology, 107 1-9 (2015)

Pregnancy provides a unique challenge for maternal immunity, requiring the ability to tolerate the presence of a semi-allogeneic foetus, and yet still being capable of inducing an immune response against invading pathogens. To achieve this, numerous changes must occur in the activity and function of maternal immune cells throughout the course of pregnancy. Respiratory viruses take advantage of these changes, altering the sensitive balance of maternal immunity, leaving the mother with increased susceptibility to viral infections and increased disease severity. Influenza virus is one of the most common respiratory virus infections during pregnancy, leading to an increased risk of ICU hospitalisations, pneumonia, acute respiratory distress syndrome and even death. Whilst much research has been performed to understand the changes that must take place in maternal immunity during pregnancy, considerable work is still needed to fully comprehend this tremendous feat. To date, few studies have focused on the alterations that occur in maternal immunity during respiratory virus infections. This review highlights the role of dendritic cells (DCs) and CD8 T cells during pregnancy, and the changes that occur in these antiviral cells following influenza virus infections.

DOI10.1016/j.jri.2014.09.051
Co-authorsPeter Wark, Philip Hansbro, Vanessa Murphy
2015Wood LG, Shivappa N, Berthon BS, Gibson PG, Hebert JR, 'Dietary inflammatory index is related to asthma risk, lung function and systemic inflammation in asthma', Clinical and Experimental Allergy, 45 177-183 (2015)

Background: Asthma prevalence has increased in recent years, and evidence suggests that diet may be a contributing factor. Increased use of processed foods has led to a decrease in diet quality, which may be creating a pro-inflammatory environment, thereby leading to the development and/or progression of various chronic inflammatory diseases and conditions. Recently, the dietary inflammatory index (DII) has been developed and validated to assess the inflammatory potential of individual diets. Objective: This study aimed to examine the DII in subjects with asthma compared to healthy controls and to relate the DII to asthma risk, lung function and systemic inflammation. Methods: Subjects with asthma (n = 99) and healthy controls (n = 61) were recruited. Blood was collected and spirometry was performed. The DII was calculated from food frequency questionnaires administered to study subjects. Results: The mean DII score for the asthmatics was higher than the mean DII score for healthy controls (- 1.40 vs. - 1.86, P = 0.04), indicating that their diets were more pro-inflammatory. For every 1 unit increase in DII score, the odds of having asthma increased by 70% (OR: 1.70, 95% CI: 1.03, 2.14; P = 0.040). FEV1 was significantly associated with DII score (ß = - 3.44, 95% CI: - 6.50, - 0.39; P = 0.020), indicating that for every 1 unit increase in DII score, FEV1 decreased by 3.44 times. Furthermore, plasma IL-6 concentrations were positively associated with DII score (ß = 0.13, 95% CI: 0.05, 0.21; P = 0.002). Conclusion and Clinical Relevance: As assessed using the DII score, the usual diet consumed by asthmatics in this study was pro-inflammatory relative to the diet consumed by the healthy controls. The DII score was associated with increased systemic inflammation and lower lung function. Hence, consumption of pro-inflammatory foods may contribute to worse asthma status, and targeting an improvement in DII in asthmatics, as an indicator of suitable dietary intake, might be a useful strategy for improving clinical outcomes in the disease.

DOI10.1111/cea.12323
CitationsScopus - 5Web of Science - 5
Co-authorsLisa Wood
2015Periyalil HA, Wood LG, Scott HA, Jensen ME, Gibson PG, 'Macrophage activation, age and sex effects of immunometabolism in obese asthma', EUROPEAN RESPIRATORY JOURNAL, 45 388-395 (2015)
DOI10.1183/09031936.00080514Author URL
Co-authorsHayley Scott, Lisa Wood
2015Berthon BS, Gibson PG, McElduff P, MacDonald-Wicks LK, Wood LG, 'Effects of short-term oral corticosteroid intake on dietary intake, body weight and body composition in adults with asthma - a randomized controlled trial.', Clin Exp Allergy, 45 908-919 (2015)
DOI10.1111/cea.12505Author URL
Co-authorsLesley Wicks, Lisa Wood
2015Baines KJ, Backer V, Gibson PG, Powel H, Porsbjerg CM, 'Impaired lung function is associated with systemic inflammation and macrophage activation.', Eur Respir J, 45 557-559 (2015) [C1]
DOI10.1183/09031936.00187514Author URL
Co-authorsKatherine Baines
2015Gibson PG, McDonald VM, 'Asthma-COPD overlap 2015: now we are six.', Thorax, 70 683-691 (2015)
DOI10.1136/thoraxjnl-2014-206740Author URL
Co-authorsVanessa Mcdonald
2015Simpson J, Yang IA, Upham JW, Reynolds PN, Hodge S, James AL, et al., 'SPUTUM AND SERUM PERIOSTIN LEVELS ARE ASSOCIATED WITH, BUT DO NOT PREDICT SPUTUM EOSINOPHIL PROPORTION IN SEVERE ASTHMA', RESPIROLOGY, 20 68-68 (2015)
Author URL
Co-authorsJodie Simpson
2015Essilfie A-T, Horvat JC, Kim RY, Mayall JR, Pinkerton JW, Beckett EL, et al., 'Macrolide therapy suppresses key features of experimental steroid-sensitive and steroid-insensitive asthma', THORAX, 70 458-U151 (2015)
DOI10.1136/thoraxjnl-2014-206067Author URL
CitationsWeb of Science - 1
Co-authorsMalcolm Starkey, Philip Hansbro, Jay Horvat, Jodie Simpson, Paul Foster
2015Scott HA, Gibson PG, Garg ML, Pretto JJ, Morgan PJ, Callister R, Wood LG, 'Determinants of weight loss success utilizing a meal replacement plan and/or exercise, in overweight and obese adults with asthma.', Respirology, 20 243-250 (2015)
DOI10.1111/resp.12423Author URL
CitationsScopus - 1Web of Science - 1
Co-authorsPhilip Morgan, Robin Callister, Manohar Garg, Hayley Scott, Lisa Wood
2015Gao P, Gibson PG, Baines KJ, Yang IA, Upham JW, Reynolds PN, et al., 'Anti-inflammatory deficiencies in neutrophilic asthma: reduced galectin-3 and IL-1RA/IL-1 beta', RESPIRATORY RESEARCH, 16 (2015)
DOI10.1189/s12931-014-0163-5Author URL
Co-authorsKatherine Baines, Jodie Simpson
2015Baines KJ, Backer V, Gibson PG, Powell H, Porsbjerg CM, 'Investigating the effects of arctic dietary intake on lung health.', Eur J Clin Nutr, (2015)
DOI10.1038/ejcn.2015.85Author URL
Co-authorsKatherine Baines
2015Mandaliya PH, Morten M, Kumar R, James A, Deshpande A, Murphy VE, et al., 'Ventilation inhomogeneities in children with congenital thoracic malformations.', BMC Pulm Med, 15 25 (2015)
DOI10.1186/s12890-015-0023-1Author URL
Co-authorsVanessa Murphy
2014Gibson PG, Foster PS, 'Asthma 2014: from monoclonals to the microbiome.', Lancet Respir Med, 2 956-958 (2014) [C3]
DOI10.1016/S2213-2600(14)70275-9Author URL
Co-authorsPaul Foster
2014Fu J-J, Mcdonald VM, Wang G, Gibson PG, 'Asthma control: How it can be best assessed?', Current Opinion in Pulmonary Medicine, 20 1-7 (2014) [C1]
DOI10.1097/MCP.0000000000000003
CitationsScopus - 2Web of Science - 1
Co-authorsVanessa Mcdonald
2014Baines KJ, Upham JW, Yerkovich ST, Chang AB, Marchant JM, Carroll M, et al., 'Mediators of neutrophil function in children with protracted bacterial bronchitis', Chest, 146 1013-1020 (2014) [C1]
DOI10.1378/chest.14-0131
CitationsScopus - 1
Co-authorsJodie Simpson, Katherine Baines
2014Fu J-J, Gibson PG, Simpson JL, McDonald VM, 'Longitudinal changes in clinical outcomes in older patients with asthma, COPD and asthma-COPD overlap syndrome', Respiration, 87 63-74 (2014) [C1]

Background: The progression of obstructive airway diseases (OADs) including asthma, chronic obstructive pulmonary disease (COPD) and asthma-COPD overlap syndrome in older adults is not well understood. Objective: To examine the prognosis of OADs and to identify potential determinants for longitudinal changes in clinical outcomes. Methods: We consecutively recruited 99 older adults (>55 years) with OADs who underwent a multidimensional assessment at baseline and 4 years which involved spirometry, 6-min walk distance (6MWD), assessments of health status (Saint George's Respiratory Questionnaire, SGRQ), comorbidity, and serum and sputum biomarkers. All-cause mortality and respiratory hospitalisation during the follow-up period were recorded. Clinical outcomes were compared between basal and final visits, and changes in clinical outcomes were compared among asthma, COPD and asthma-COPD overlap groups. Associations between clinical parameters, biomarkers and prognosis were examined. Results: After a median follow-up of 4.2 years, outcome data were available for 75 (75.8%) patients. There were 16 (16.2%) deaths. The BODE index predicted all-cause mortality in older people with OADs. While spirometry, 6MWD and SGRQ deteriorated significantly over the 4 years, there was significant heterogeneity in the longitudinal changes in these clinical outcomes. Participants with COPD had a significant decline in FEV1 (p = 0.003), SGRQ (p = 0.030) and 6MWD [decline of 75.5 (93.4) m, p = 0.024]. The change in 6MWD was lower in the asthma-COPD overlap group. Airflow reversibility was associated with a reduced decline in 6MWD. Conclusion: COPD patients had a poor prognosis compared with asthma and asthma-COPD overlap patients. The BODE index is a useful prognostic indicator in older adults with OADs. Both airway disease diagnosis and BODE index warrant specific attention in clinical practice. © 2013 S. Karger AG, Basel.

DOI10.1159/000352053
CitationsScopus - 11Web of Science - 7
Co-authorsVanessa Mcdonald, Jodie Simpson
2014Jensen ME, Gibson PG, Collins CE, Wood LG, 'Lean mass, not fat mass, is associated with lung function in male and female children with asthma', Pediatric Research, 75 93-98 (2014) [C1]

Background:Whether body composition is associated with lung function in asthmatic children has not been investigated. This study aimed to primarily investigate whether BMI z-score and body composition were associated with respiratory function in asthmatic children.Methods:In a cross-sectional study, male (n = 27; mean age: 11.9 y (SD: 2.3)) and female (n = 21; mean age: 13.6 y (SD: 2.2)) asthmatic children underwent clinical assessment.Results:BMI z-score was associated with forced expiratory volume in 1 s (FEV 1; r = 0.458), forced vital capacity (FVC; r = 0.477), and total lung capacity (TLC; r = 0.451) in males only (P < 0.05). Total lean mass was associated with FEV 1 (r = 0.655), FVC (r = 0.562), and TLC (r = 0.635) in males, as was thoracic lean mass (FEV 1 (r = 0.573), FVC (r = 0.526), and TLC (r = 0.497); P < 0.05). TLC was associated with total (r = 0.522) and thoracic (r = 0.532) lean mass in females (P < 0.05). Fat mass was not associated with lung function in this group.Conclusion:Lean mass, not fat mass, is associated with lung function in children with asthma. The positive association between BMI z-score and respiratory function in male children is driven by lean mass. Although body weight can be easily monitored in the clinical setting, body composition can provide important information. Future research exploring lean mass and lung function associations could inform future interventions. Copyright © 2014 International Pediatric Research Foundation, Inc.

DOI10.1038/pr.2013.181
CitationsScopus - 2Web of Science - 1
Co-authorsClare Collins, Lisa Wood
2014Mattes J, Murphy VE, Powell H, Gibson PG, 'Prenatal origins of bronchiolitis: Protective effect of optimised asthma management during pregnancy', Thorax, 69 383-384 (2014) [C1]

Objective Maternal asthma is the most common chronic disease complicating pregnancy and is a risk factor for bronchiolitis in infancy. Recurrent episodes of bronchiolitis are strongly associated with the development of childhood asthma. Methods We conducted a follow-up study of infants born to women with asthma who completed a double-blind randomised controlled trial during pregnancy. In this trial, pregnant women with asthma were assigned to treatment adjustment by an algorithm using clinical symptoms (clinical group) or the fraction of exhaled nitric oxide (FeNO group) and we showed that the FeNO group had significantly lower asthma exacerbation rates in pregnancy. Results 146 infants attended the 12-month follow-up visit. Infants born to mothers from the FeNO group were significantly less likely to have recurrent episodes of bronchiolitis in the first year of life (OR 0.08, 95% CI 0.01 to 0.62; p=0.016) as compared with the clinical group. Conclusions Optimised management of asthma during pregnancy may reduce recurrent episodes of bronchiolitis in infancy, which could potentially modulate the risk to develop or the severity of emerging childhood asthma.

DOI10.1136/thoraxjnl-2013-203388
CitationsScopus - 5Web of Science - 3
Co-authorsVanessa Murphy, Joerg Mattes
2014Mattes J, Gibson PG, 'The early origins of copd in severe asthma: The one thing that leads to another or the two things that come together?', Thorax, 69 789-790 (2014)
DOI10.1136/thoraxjnl-2013-204815
Co-authorsJoerg Mattes
2014Simpson JL, Baines KJ, Ryan N, Gibson PG, 'Neutrophilic asthma is characterised by increased rhinosinusitis with sleep disturbance and GERD', Asian Pacific Journal of Allergy and Immunology, 32 66-74 (2014) [C1]

Background: Asthma is a heterogeneous inflammatory disease and eosinophilic, noneosinophilic and neutrophilic forms are recognised. While clinically similar to eosinophilic asthma, patients with non-eosinophilic asthma have different responses to treatment and little is known about the triggers of symptoms and inflammation. Objective: This study sought to characterise asthma control, exacerbation frequency and potential triggers of non-eosinophilic and specifically neutrophilic asthma such as infection, gastroesophageal reflux disease, and rhinosinusitis. Methods: Adults with asthma (n=65; doctor's diagnosis plus demonstrated response to bronchodilator and/or airways hyperresponsiveness to hypertonic saline) were recruited from the Respiratory and Sleep Medicine Ambulatory Care Service at John Hunter Hospital, NSW, Australia. Questionnaires were administered to assess gastroesophageal reflux disease, rhinosinusitis and asthma control. A sputum induction was performed and sputum was processed for assessment of inflammatory cells, infection, and lipid laden macrophages (Oil Red O). Results: Participants with neutrophilic asthma (n=11, 23%) had a higher frequency of primary care doctor visits for asthma exacerbations and a high prevalence (>70%) of chest infections in the previous 12 months. There was also an increased prevalence of rhinosinusitis (64%) and increased symptoms of gastroesophageal reflux disease compared to those with eosinophilic asthma. Conclusions: The clinical pattern of neutrophilic asthma is different from paucigranulocytic and eosinophilic asthma with evidence of abnormal upper airways responses. Specific and targeted treatment of these airway problems may assist in the control and management of neutrophilic asthma.

DOI10.12932/AP0322.32.1.2014
CitationsScopus - 1
Co-authorsKatherine Baines, Nicole Ryan, Jodie Simpson
2014Chung KF, Wenzel SE, Brozek JL, Bush A, Castro M, Sterk PJ, et al., 'International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma', EUROPEAN RESPIRATORY JOURNAL, 43 343-373 (2014) [C1]
DOI10.1183/09031936.00202013Author URL
CitationsWeb of Science - 77
2014Simpson JL, Phipps S, Baines KJ, Oreo KM, Gunawardhana L, Gibson PG, 'Elevated expression of the NLRP3 inflammasome in neutrophilic asthma', European Respiratory Journal, 43 1067-1076 (2014) [C1]

Asthma is a heterogeneous inflammatory airways disorder where interleukin (IL)-1ß is thought to be a key mediator, especially in the neutrophilic subtype of asthma. The generation of active IL-1ß requires proteolytic cleavage typically mediated through the formation of a caspase-1-containing inflammasome. This study hypothesised that an IL-1ß endotype associated with the nucleotide-binding domain, leucine-rich repeat-containing family protein (NLRP)3/apoptosis-associated speck-like protein containing a caspase-recruitment domain (ASC)/caspase-1 inflammasome is characteristic of patients with the neutrophilic subtype of asthma. Participants with asthma (n=85) and healthy controls (n=27) underwent clinical assessment, spirometry and sputum induction. Sputum was processed for differential cell count, gene expression and protein mediators. NLRP3 and caspase-1 expression was also determined by immunocytochemistry. Sputum macrophages were isolated (n=8) and gene expression of NLRP3 and IL-1ß determined. There was significantly elevated gene expression of NLRP3, caspase-1, caspase-4, caspase-5 and IL-1ß in participants with neutrophilic asthma. Protein levels of IL-1ß were significantly higher in those with neutrophilic asthma and correlated with sputum IL-8 levels. Sputum macrophages, as well as sputum neutrophils in neutrophilic asthma, expressed NLRP3 and caspase-1 protein. NLRP3 inflammasome is upregulated in neutrophilic asthma and may regulate the inflammation process observed in this asthma phenotype through production of IL-1ß. Copyright © ERS 2014.

DOI10.1183/09031936.00105013
CitationsScopus - 9Web of Science - 9
Co-authorsJodie Simpson, Katherine Baines
2014Murphy VE, Mattes J, Powell H, Baines KJ, Gibson PG, 'Respiratory viral infections in pregnant women with asthma are associated with wheezing in the first 12 months of life', Pediatric Allergy and Immunology, 25 151-158 (2014) [C1]

Background: There are few studies investigating the relationship between respiratory viral infection in pregnancy and asthma in the offspring, and none among mothers with asthma. Infants of mothers with asthma are more likely to wheeze and have a higher risk of developing asthma than infants of non-asthmatic mothers. Methods: A prospective cohort study of viral infection in pregnancy was conducted between 2007 and 2009, and a subgroup of infants of mothers with asthma was followed up at 6 and 12 months of age. During common colds, nasal and throat swabs were collected from mothers and respiratory viruses detected by polymerase chain reaction. Respiratory health of infants was assessed by parent-completed questionnaire. Results: Twelve-month-old infants whose mothers had confirmed viral infections in pregnancy (n = 26) reported more frequent wheeze (40% had 4-12 wheeze attacks compared with 0%), sleep disturbed by wheeze (1 night per week or more in 60% vs. 11%), beta agonist treatment for wheeze (27% vs. 0%), prolonged colds (2 wk or longer 31% vs. 0%), more eczema (40% vs. 6.3%), and parent-perceived asthma (32% vs. 0%), compared with infants whose mothers had common colds without laboratory-confirmed viral infection (n = 16). Conclusions: This study demonstrates a relationship between maternal respiratory viral infection in pregnancy and wheezing illness in infants of mothers with asthma. Viral infections are the most common cause of asthma exacerbations in pregnancy, and infants of asthmatic mothers are at increased risk of asthma themselves. Further research is needed to elucidate the mechanisms involved. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

DOI10.1111/pai.12156
CitationsScopus - 2Web of Science - 2
Co-authorsKatherine Baines, Joerg Mattes, Vanessa Murphy
2014Oreo KM, Gibson PG, Simpson JL, Wood LG, Mcdonald VM, Baines KJ, 'Sputum ADAM8 expression is increased in severe asthma and COPD', Clinical and Experimental Allergy, 44 342-352 (2014) [C1]

Background: Severe asthma and chronic obstructive pulmonary disease (COPD) are chronic inflammatory airway diseases in which the mechanisms are not fully understood. A disintegrin and metalloproteinase domain 8 (ADAM8) is an enzyme expressed on most leucocytes and may be important for facilitating leucocyte migration in respiratory disease. Objective: To investigate ADAM8 mRNA and protein expression in asthma and COPD and its relationship between asthma severity and inflammatory phenotypes. Methods: Induced sputum was collected from 113 subjects with asthma (severe n = 31, uncontrolled n = 39 and controlled n = 35), 20 subjects with COPD and 21 healthy controls. Sputum ADAM8 mRNA expression was measured by qPCR, and soluble ADAM8 (sADAM8) protein was measured in the sputum supernatant by validated ELISA. Results: ADAM8 mRNA correlated with ADAM8 protein levels (r = 0.27, P < 0.01). ADAM8 mRNA (P = 0.004) and sADAM8 protein (P = 0.014) levels were significantly higher in both asthma and COPD compared with healthy controls. ADAM8 mRNA (P = 0.035) and sADAM8 protein (P = 0.002) levels were significantly higher in severe asthma compared with controlled asthma. Total inflammatory cell count (P < 0.01) and neutrophils (P < 0.01) were also elevated in severe asthmatic sputum. Although ADAM8 mRNA was significantly higher in eosinophilic and neutrophilic asthma (P < 0.001), sADAM8 did not differ between asthma inflammatory phenotypes. ADAM8 expression positively correlated with sputum total cell count and sputum neutrophils. Conclusions and Clinical Relevance: ADAM8 expression is increased in both severe asthma and COPD and associated with sputum total cell count and neutrophils. ADAM8 may facilitate neutrophil migration to the airways in severe asthma and COPD. © 2013 John Wiley & Sons Ltd.

DOI10.1111/cea.12223
CitationsScopus - 1Web of Science - 1
Co-authorsJodie Simpson, Katherine Baines, Vanessa Mcdonald, Lisa Wood
2014Zhang X-Y, Simpson JL, Powell H, Yang IA, Upham JW, Reynolds PN, et al., 'Full blood count parameters for the detection of asthma inflammatory phenotypes', Clinical and Experimental Allergy, 44 1137-1145 (2014) [C1]

Summary: Background: In asthma, the airway inflammatory phenotype influences clinical characteristics and treatment response. Although induced sputum is the gold standard test for phenotyping asthma, a more accessible method is needed for clinical practice. Objective: To investigate whether white blood cell counts and/or their derived ratios can predict sputum eosinophils or neutrophils in uncontrolled asthma. Methods: This cross-sectional study evaluated 164 treated but uncontrolled asthmatic patients with sputum induction and blood collection. Receiver-operating characteristic (ROC) curves were used to assess the relationship between blood and sputum parameters. Results: There was a significant positive relationship between blood eosinophil parameters and the percentage of sputum eosinophil count. A weak but significant correlation was found between sputum neutrophil percentage and blood neutrophil percentage (r = 0.219, P = 0.005). ROC curve analysis identified that blood eosinophil percentage count was the best predictor for eosinophilic asthma, with an area under the curve (AUC) of 0.907 (P < 0.001). The optimum cut-point for blood eosinophil percentage was 2.7%, and this yielded a sensitivity of 92.2% and a specificity of 75.8%. The absolute blood eosinophil count was also highly predictive with an AUC of 0.898 (P < 0.0001) at a blood eosinophil cut-off of 0.26 × 109/L. The blood eosinophil/lymphocyte ratio (ELR) and eosinophil/neutrophil ratio (ENR) were increased in eosinophilic asthma, and the neutrophil/lymphocyte ratio (NLR) was increased in neutrophilic asthma. Neutrophilic asthma could also be detected by blood neutrophil percentages and NLR, but with less accuracy. Conclusions and Clinical Relevance: Blood eosinophil counts and derived ratios (ELR and ENR) can accurately predict eosinophilic asthma in patients with persistent uncontrolled asthma despite treatment. Blood neutrophil parameters are poor surrogates for the proportion of sputum neutrophils. Blood counts may be a useful aid in the monitoring of uncontrolled asthma. © 2014 John Wiley & Sons Ltd.

DOI10.1111/cea.12345
CitationsScopus - 5Web of Science - 6
Co-authorsJodie Simpson
2014Fu J-J, McDonald VM, Wang G, Gibson PG, 'Asthma control: how it can be best assessed?', CURRENT OPINION IN PULMONARY MEDICINE, 20 1-7 (2014)
DOI10.1097/MCP.0000000000000003Author URL
CitationsScopus - 2Web of Science - 1
Co-authorsVanessa Mcdonald
2014Zhang HP, Jia CE, Lv Y, Gibson PG, Wang G, 'Montelukast for prevention and treatment of asthma exacerbations in adults: Systematic review and meta-analysis', Allergy and Asthma Proceedings, 35 278-287 (2014) [C1]

It has proven efficacy in reducing asthma exacerbations, but the effect size of montelukast (a leukotriene receptor antagonist) for varied severity of asthma exacerbations is not systematically assessed. This study was designed to systematically explore the evidence for montelukast, as first-line or add-on therapy, in preventing and treating asthma exacerbations in adult patients with asthma. Randomized controlled trials were searched in PubMed, CENTRAL, COPY Web of Science, Embase, and OVID up to March 2013, where montelukast prevented or treated asthma exacerbations in adults. Primary outcomes were the number of patients experiencing exacerbations in chronic asthma and hospitalizations in acute asthma. Odds ratio (OR) with 95% confidence intervals (CI), risk difference, and number needed to treat (NNT) were calculated and pooled. Adverse events were also assessed in chronic asthma. Twenty trials for chronic asthma and six for acute asthma were identified. In comparison with placebo, adults with chronic asthma receiving montelukast had significantly reduced number of exacerbations (OR = 0.60 and 95% CI, 0.49, 0.74; NNT = 17 and 95% CI, 12, 29). However, montelukast was inferior to inhaled corticosteroids (ICSs) (OR = 1.63; 95% CI, 1.29, 2.0) and ICS plus long-acting beta2-agonist (LABA; OR = 3.94; 95% CI, 1.64, 9.48) as the first-line therapies and LABA (OR = 1.22; 95% CI, 1.05, 1.42) as the add-on therapies in reducing asthma exacerbations. In acute asthma, montelukast could statistically improve peak expiratory flow percent predicted (p = 0.008) and reduce systemic corticosteroid intake (p = 0.005). Montelukast had low risk in hoarseness and insomnia. Our meta-analysis suggests that montelukast significantly reduces mild, moderate, and part of severe exacerbations in chronic mild to moderate asthma, but it has inferior efficacy to ICS or ICS plus LABA. Copyright © 2014, OceanSide Publications, Inc.

DOI10.2500/aap.2014.35.3745
CitationsScopus - 2Web of Science - 3
2014Simpson JL, Gibson PG, Yang IA, Upham J, James A, Reynolds PN, Hodge S, 'Altered sputum granzyme B and granzyme B/proteinase inhibitor-9 in patients with non-eosinophilic asthma', RESPIROLOGY, 19 280-287 (2014) [C1]
DOI10.1111/resp.12213Author URL
CitationsScopus - 1Web of Science - 1
Co-authorsJodie Simpson
2014Gibson P, 'Laryngeal botoxification for severe asthma', RESPIROLOGY, 19 467-468 (2014) [C3]
DOI10.1111/resp.12278Author URL
CitationsWeb of Science - 1
2014Gunawardhana LP, Gibson PG, Simpson JL, Powell H, Baines KJ, 'Activity and expression of histone acetylases and deacetylases in inflammatory phenotypes of asthma', Clinical & Experimental Allergy, 44 47-57 (2014) [C1]
DOI10.1111/cea.12168Author URL
CitationsScopus - 2Web of Science - 2
Co-authorsKatherine Baines, Jodie Simpson
2014Gibson PG, Simpson JL, Ryan NM, Vertigan AE, 'Mechanisms of cough', CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 14 55-61 (2014) [C1]
DOI10.1097/ACI.0000000000000027Author URL
CitationsScopus - 3Web of Science - 3
Co-authorsJodie Simpson, Nicole Ryan
2014Vertigan AE, Bone SL, Gibson PG, 'Development and validation of the Newcastle laryngeal hypersensitivity questionnaire', Acta Veterinaria Scandinavica, 10 1-13 (2014) [C1]
DOI10.1186/1745-9974-10-1
CitationsScopus - 1
2014Simpson JL, Powell H, Baines KJ, Milne D, Coxson HO, Hansbro PM, Gibson PG, 'The Effect of Azithromycin in Adults with Stable Neutrophilic COPD: A Double Blind Randomised, Placebo Controlled Trial', PLOS ONE, 9 (2014) [C1]
DOI10.1371/journal.pone.0105609Author URL
CitationsScopus - 3Web of Science - 1
Co-authorsKatherine Baines, Philip Hansbro, Jodie Simpson
2014Mattes J, Gibson PG, 'The early origins of copd in severe asthma: The one thing that leads to another or the two things that come together?', Thorax, 69 789-790 (2014) [C3]
DOI10.1136/thoraxjnl-2013-204815
CitationsScopus - 1Web of Science - 1
Co-authorsJoerg Mattes
2014Baines KJ, Simpson JL, Wood LG, Scott RJ, Fibbens NL, Powell H, et al., 'Sputum gene expression signature of 6 biomarkers discriminates asthma inflammatory phenotypes', Journal of Allergy and Clinical Immunology, 133 997-1007 (2014) [C1]

Background Airway inflammation is associated with asthma exacerbation risk, treatment response, and disease mechanisms. Objective This study aimed to identify and validate a sputum gene expression signature that discriminates asthma inflammatory phenotypes. Methods An asthma phenotype biomarker discovery study generated gene expression profiles from induced sputum of 47 asthmatic patients. A clinical validation study (n = 59 asthmatic patients) confirmed differential expression of key genes. A 6-gene signature was identified and evaluated for reproducibility (n = 30 asthmatic patients and n = 20 control subjects) and prediction of inhaled corticosteroid (ICS) response (n = 71 asthmatic patients). Receiver operating characteristic curves were calculated, and area under the curve (AUC) values were reported. Results From 277 differentially expressed genes between asthma inflammatory phenotypes, we identified 23 genes that showed highly significant differential expression in both the discovery and validation populations. A signature of 6 genes, including Charcot-Leydon crystal protein (CLC); carboxypeptidase A3 (CPA3); deoxyribonuclease I-like 3 (DNASE1L3); IL-1ß (IL1B); alkaline phosphatase, tissue-nonspecific isozyme (ALPL); and chemokine (C-X-C motif) receptor 2 (CXCR2), was reproducible and could significantly (P <.0001) discriminate eosinophilic asthma from other phenotypes, including patients with noneosinophilic asthma (AUC, 89.6%), paucigranulocytic asthma (AUC, 92.6%), or neutrophilic asthma (AUC, 91.4%) and healthy control subjects (AUC, 97.6%), as well as discriminating patients with neutrophilic asthma from those with paucigranulocytic asthma (AUC, 85.7%) and healthy control subjects (AUC, 90.8). The 6-gene signature predicted ICS response (>12% change in FEV1; AUC, 91.5%). ICS treatment reduced the expression of CLC, CPA3, and DNASE1L3 in patients with eosinophilic asthma. Conclusions A sputum gene expression signature of 6 biomarkers reproducibly and significantly discriminates inflammatory phenotypes of asthma and predicts ICS treatment response. This signature has the potential to become a useful diagnostic tool to assist in the clinical diagnosis and management of asthma. © 2013 American Academy of Allergy, Asthma & Immunology.

DOI10.1016/j.jaci.2013.12.1091
CitationsScopus - 11Web of Science - 12
Co-authorsLisa Wood, Jodie Simpson, Rodney Scott, Katherine Baines
2014Ryan NM, Gibson PG, 'Recent additions in the treatment of cough', JOURNAL OF THORACIC DISEASE, 6 S739-S747 (2014) [C1]
DOI10.3978/j.issn.2072-1439.2014.03.13Author URL
CitationsWeb of Science - 1
Co-authorsNicole Ryan
2014Ryan NM, Birring SS, Gibson PG, 'Arnold¿s nerve cough reflex: evidence for chronic cough as a sensory vagal neuropathy', Journal of Thoracic Disease, 6 S748-S752 (2014) [C3]
DOI10.3978/j.issn.2072-1439.2014.04.22
Co-authorsNicole Ryan
2014Fu J-J, McDonald VM, Gibson PG, Simpson JL, 'Systemic inflammation in older adults with asthma-COPD overlap syndrome', Allergy, Asthma and Immunology Research, 6 316-324 (2014) [C1]

Purpose: The role of systemic inflammation on asthma-COPD overlap syndrome is unknown. This study aimed to examine systemic inflammation in asthma-COPD overlap syndrome, and to identify associations between clinical characteristics and inflammatory mediators in asthma-COPD overlap syndrome. Methods: In 108 adults older than 55 years comprising healthy controls (n=29), asthma (n=16), COPD (n=21) and asthma-COPD overlap syndrome (n=42), serum high sensitivity C-reactive protein and Interleukin 6 (IL-6) were assayed. Spirometry, induced sputum, quality of life, comorbidities and medications were assessed, and their associations with asthma-COPD overlap syndrome were analyzed using logistic regression. Associations between systemic inflammatory mediators and clinical characteristics were tested in multivariate linear regression models. Results: Patients with asthma-COPD overlap syndrome had significantly elevated IL-6 levels compared with healthy controls and asthmatics. Age, comorbidity index and IL-6 level were independently associated with asthma-COPD overlap syndrome. FEV1% predicted was inversely associated with IL-6 level, and cardiovascular disease was associated with an increased IL-6 level. Systemic markers were not associated with airway inflammation. Conclusions: Systemic inflammation is commonly present in asthma-COPD overlap syndrome, and asthma-COPD overlap syndrome resembled COPD in terms of systemic inflammation. IL-6 is a pivotal inflammatory mediator that may be involved in airflow obstruction and cardiovascular disease and may be an independent treatment target. © Copyright The Korean Academy of Asthma, Allergy and Clinical Immunology.

DOI10.4168/aair.2014.6.4.316
CitationsScopus - 6Web of Science - 5
Co-authorsJodie Simpson, Vanessa Mcdonald
2014Gunawardhana LP, Baines KJ, Mattes J, Murphy VE, Simpson JL, Gibson PG, 'Differential DNA methylation profiles of infants exposed to maternal asthma during pregnancy', Pediatric Pulmonology, 49 852-862 (2014) [C1]

Background Asthma is a complex disease that involves both genetic factors and environmental exposures. Aberrant epigenetic modifications, such as DNA methylation, may be important in asthma development. Fetal exposure to maternal asthma during critical periods of in utero development may lead to epigenetic alterations that predispose infants to a greater risk of developing asthma themselves. We investigated alterations in the DNA methylation profile of peripheral blood from infants exposed to maternal asthma during pregnancy. Methods Peripheral blood was collected from 12-month-old infants born to women with (n = 25) and without (n = 15) doctor diagnosed asthma during pregnancy. Genomic DNA was extracted, bisulfite converted, and hybridized to Infinium Methylation 27 arrays (Illumina), containing over27,000 CpGs from 14,495 genes. CpG loci in only autosomal genes were classified as differentially methylated at the 99% level (P < 0.01, |DiffScore| > 22 and delta beta >0.06). Results There were 70 CpG loci, corresponding to 67 genes that were significantly differentially methylated. Twelve CpG loci (11 genes) showed greater than 10% comparative difference in DNA methylation, including hyper-methylated loci of FAM181A, MRI1, PIWIL1, CHFR, DEFA1, MRPL28, AURKA, and hypo-methylated loci of NALP1L5, MAP8KIP3, ACAT2, and PM20D1 in maternal asthma. Methylation of MAPK8IP3 was significantly negatively correlated with maternal blood eosinophils (r = -0.38; P = 0.022), maternal eNO (r = -0.44; P = 0.005), and maternal serum total IgE (r = -0.39, P = 0.015). Methylation of AURKA negatively correlated with maternal hemoglobin (r = -0.43; P = 0.008), infants height (r = -0.51; P < 0.001) and weight (r = -0.36; P = 0.021). Methylation of PM20D1 was lower in infants born to mothers with asthma on inhaled corticosteroid treatment. Methylation of PM20D1 was lower and MRI1 was higher in infants born to atopic mothers without asthma. Conclusions In an Australian study population, exposure to maternal asthma during pregnancy is associated with differential methylation profiles of infants' peripheral blood DNA, which may act as risk factors for future asthma development. © 2013 Wiley Periodicals, Inc.

DOI10.1002/ppul.22930
CitationsScopus - 3Web of Science - 2
Co-authorsJodie Simpson, Joerg Mattes, Vanessa Murphy, Katherine Baines
2014Walters JAE, Tan DJ, White CJ, Gibson PG, Wood-Baker R, Walters EH, 'Systemic corticosteroids for acute exacerbations of chronic obstructive pulmonary disease', COCHRANE DATABASE OF SYSTEMATIC REVIEWS, (2014) [C1]
DOI10.1002/14651858.CD001288.pub4Author URL
CitationsWeb of Science - 1
2014Simpson JL, Guest M, Boggess MM, Gibson PG, 'Occupational exposures, smoking and airway inflammation in refractory asthma', BMC PULMONARY MEDICINE, 14 (2014) [C1]
DOI10.1186/1471-2466-14-207Author URL
Co-authorsMaya Guest, Jodie Simpson
2014Wang G, Murphy VE, Namazy J, Powell H, Schatz M, Chambers C, et al., 'The risk of maternal and placental complications in pregnant women with asthma: A systematic review and meta-analysis', Journal of Maternal-Fetal and Neonatal Medicine, 27 934-942 (2014) [C1]

Objective: To investigate if maternal asthma is associated with an increased risk of maternal and placental complications in pregnancy. Methods: Electronic databases were searched for the following terms: (asthma or wheeze) and (pregnan* or perinat* or obstet*). Cohort studies published between January 1975 and March 2012 were considered for inclusion. Forty publications met the inclusion criteria, reporting at least one maternal or placental complication in pregnant women with and without asthma. Relative risk (RR) with 95% confidence intervals (CIs) was calculated. Results: Maternal asthma was associated with a significantly increased risk of cesarean section (RR=1.31, 95%CI=[1.22-1.39]), gestational diabetes (RR=1.39, 95%CI=[1.17-1.66]), hemorrhage (antepartum: RR=1.25, 95%CI=[1.10-1.42]; postpartum: RR=1.29, 95%CI=[1.18-1.41]), placenta previa (RR=1.23, 95%CI=[1.07-1.40]), placental abruption (RR=1.29, 95%CI=[1.14-1.47]) and premature rupture of membranes (RR=1.21, 95%CI=1.07-1.37). Moderate to severe asthma significantly increased the risk of cesarean section (RR=1.19, 95%CI=[1.09-1.31]) and gestational diabetes (RR=1.19, 95%CI=[1.06-1.33]) compared to mild asthma. Bronchodilator use was associated with a significantly lowered risk of gestational diabetes (RR=0.64, 95%CI=[0.57-0.72]). Conclusions: Pregnant women with asthma are at increased risk of maternal and placental complications, and women with moderate/severe asthma may be at particular risk. Further studies are required to elucidate whether adequate control of asthma during pregnancy reduces these risks. © 2014 Informa UK Ltd. All rights reserved.

DOI10.3109/14767058.2013.847080
CitationsScopus - 5Web of Science - 4
Co-authorsVanessa Murphy, John Attia
2014Gunawardhana LP, Gibson PG, Simpson JL, Benton MC, Lea RA, Baines KJ, 'Characteristic DNA methylation profiles in peripheral blood monocytes are associated with inflammatory phenotypes of asthma.', Epigenetics, 9 1302-1316 (2014) [C1]
DOI10.4161/epi.33066Author URL
CitationsScopus - 2Web of Science - 3
Co-authorsKatherine Baines, Jodie Simpson
2014Gibson PG, McDonald VM, 'Why is COPD phenotyping like sorting diamonds?', Eur Respir J, 44 277-279 (2014) [C3]
DOI10.1183/09031936.00091214Author URL
Co-authorsVanessa Mcdonald
2014Baines KJ, Pavord ID, Gibson PG, 'The role of biomarkers in the management of airways disease.', Int J Tuberc Lung Dis, 18 1264-1268 (2014) [C1]
DOI10.5588/ijtld.14.0226Author URL
CitationsScopus - 3Web of Science - 1
Co-authorsKatherine Baines
2014Negewo NA, McDonald VM, Gibson PG, 'Comorbidity in chronic obstructive pulmonary disease', Respiratory Investigation, (2014)

Patients with chronic obstructive pulmonary diseases (COPD) often experience comorbid conditions. The most common comorbidities that have been associated with COPD include cardiovascular diseases, lung cancer, metabolic disorder, osteoporosis, anxiety and depression, skeletal muscle dysfunction, cachexia, gastrointestinal diseases, and other respiratory conditions. Not only are comorbidities common but they also considerably influence disease prognosis and patients' health status, and are associated with poor clinical outcomes. However, perusal of literature indicates that little has been done so far to effectively assess, manage, and treat comorbidities in patients with COPD. The aim of this review is to comprehensively narrate the comorbid conditions that often coexist with COPD, along with their reported prevalence and their significant impacts in the disease management of COPD. A perspective on integrated disease management approaches for COPD is also discussed.

DOI10.1016/j.resinv.2015.02.004
Co-authorsVanessa Mcdonald
2013Gibson PG, 'Induced Sputum', APSR Respiratory Updates, 5 1-7 (2013) [C3]
2013Gibson PG, 'Obesity and asthma.', Ann Am Thorac Soc, 10 Suppl S138-S142 (2013) [C1]
DOI10.1513/AnnalsATS.201302-038AWAuthor URL
CitationsScopus - 4
2013Periyalil HA, Gibson PG, Wood LG, 'Immunometabolism in obese asthmatics: Are we there yet?', Nutrients, 5 3506-3530 (2013) [C1]

Obesity is now recognised as a worldwide epidemic. The recent International Association for the Study of Obesity/International Obesity Taskforce (IASO/IOTF) analysis estimates that approximately 1.0 billion adults are currently overweight and a further 475 million are obese. Obesity has huge psychosocial impact with obese children and adolescents facing discrimination and stigmatization in many areas of their lives leading to body dissatisfaction, low self-esteem and depression. Indeed, obesity is recognised as an important risk factor for the development of several chronic diseases such as hypertension, cancer, asthma and metabolic syndrome. Chronic low grade systemic inflammation is considered as a hallmark of obesity and may possibly explain the link between obesity and chronic disease, in particular the increased incidence, prevalence and severity of asthma in obese individuals. There is now strong evidence for infiltration of immune and inflammatory cells into adipose tissue that drives systemic inflammation and subsequent end organ damage. In addition to adipocytes, the key adipose tissue resident immune cells are macrophages and mast cells. Immunometabolism, as an emerging field of investigation, explores the pivotal role of these immune cells in translating immunological changes to metabolic effects in obesity. Abundance of free fatty acids, along with other inflammatory cytokines shift the balance of metabolic homeostasis to pro-inflammatory status by influencing the development of inflammatory cell lineage, which, further exhibits distinct functional phenotypes. There is emerging evidence for macrophage activation and functional polarization of an anti-inflammatory M2 phenotype towards a pro-inflammatory M1 phenotype of macrophages in obese adipose tissue. Similarly, studies in both obese humans and murine models reveal the pathognomic presence of an increased number of mast cells in visceral adipose tissue. These suggest a possible contribution of mast cells to the unique metabolome of obese asthma. This review examines proposed multilevel interactions between metabolic and immune systems in obese asthmatics that underlie the negative effects of obesity and may offer significant therapeutic promise. © 2013 by the authors; licensee MDPI, Basel, Switzerland.

DOI10.3390/nu5093506
CitationsScopus - 3Web of Science - 3
Co-authorsLisa Wood
2013Murphy VE, Powell H, Wark PAB, Gibson PG, 'A Prospective Study of Respiratory Viral Infection in Pregnant Women With and Without Asthma', CHEST, 144 420-427 (2013) [C1]
DOI10.1378/chest.12-1956Author URL
CitationsScopus - 6Web of Science - 2
Co-authorsPeter Wark, Vanessa Murphy
2013McDonald V, Wood L, Baines P, Higgins I, Gibson P, 'Obesity and bone health in COPD', EUROPEAN RESPIRATORY JOURNAL, 42 (2013)
Author URL
Co-authorsIsabel Higgins, Lisa Wood
2013Thorburn AN, Brown AC, Nair PM, Chevalier N, Foster PS, Gibson PG, Hansbro PM, 'Pneumococcal Components Induce Regulatory T Cells That Attenuate the Development of Allergic Airways Disease by Deviating and Suppressing the Immune Response to Allergen', JOURNAL OF IMMUNOLOGY, 191 4112-4120 (2013) [C1]
DOI10.4049/jimmunol.1201232Author URL
CitationsScopus - 4Web of Science - 3
Co-authorsPaul Foster, Philip Hansbro
2013Vanders RL, Gibson PG, Murphy VE, Wark PAB, 'Plasmacytoid Dendritic Cells and CD8 T Cells From PregnantWomen Show Altered Phenotype and Function Following H1N1/09 Infection', JOURNAL OF INFECTIOUS DISEASES, 208 1062-1070 (2013) [C1]
DOI10.1093/infdis/jit296Author URL
CitationsScopus - 4Web of Science - 4
Co-authorsPeter Wark, Vanessa Murphy
2013Gibson PG, 'Macrolides for yet another chronic airway disease: severe asthma?', THORAX, 68 313-314 (2013) [C3]
DOI10.1136/thoraxjnl-2012-203055Author URL
CitationsScopus - 1
2013McDonald VM, Higgins I, Wood LG, Gibson PG, 'Multidimensional assessment and tailored interventions for COPD: respiratory utopia or common sense?', THORAX, 68 691-694 (2013) [C1]
DOI10.1136/thoraxjnl-2012-202646Author URL
CitationsScopus - 18Web of Science - 14
Co-authorsLisa Wood, Vanessa Mcdonald, Isabel Higgins
2013Jia CE, Zhang HP, Lv Y, Liang R, Jiang YQ, Powell H, et al., 'The Asthma Control Test and Asthma Control Questionnaire for assessing asthma control: Systematic review and meta-analysis', JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 131 695-703 (2013) [C1]
DOI10.1016/j.jaci.2012.08.023Author URL
CitationsScopus - 34Web of Science - 30
2013Ryan NM, Birring SS, Gibson PG, 'Gabapentin for refractory chronic cough Reply', LANCET, 381 624-625 (2013) [C3]
Author URL
CitationsScopus - 2Web of Science - 2
Co-authorsNicole Ryan
2013Powell H, McCaffery K, Murphy VE, Hensley MJ, Clifton VL, Giles W, Gibson PG, 'Psychosocial Variables Are Related to Future Exacerbation Risk and Perinatal Outcomes in Pregnant Women with Asthma', JOURNAL OF ASTHMA, 50 383-389 (2013) [C1]
DOI10.3109/02770903.2012.757777Author URL
CitationsScopus - 6Web of Science - 5
Co-authorsMichael Hensley, Vanessa Murphy
2013McDonald VM, Higgins I, Gibson PG, 'Insight into Older Peoples' Healthcare Experiences with Managing COPD, Asthma, and Asthma-COPD Overlap', JOURNAL OF ASTHMA, 50 497-504 (2013) [C1]
DOI10.3109/02770903.2013.790415Author URL
CitationsScopus - 3Web of Science - 4
Co-authorsIsabel Higgins, Vanessa Mcdonald
2013Namazy JA, Murphy VE, Powell H, Gibson PG, Chambers C, Schatz M, 'Effects of asthma severity, exacerbations and oral corticosteroids on perinatal outcomes', EUROPEAN RESPIRATORY JOURNAL, 41 1082-1090 (2013) [C1]
DOI10.1183/09031936.00195111Author URL
CitationsScopus - 17Web of Science - 13
Co-authorsVanessa Murphy
2013Gibson PG, 'Why inflammatory phenotyping is necessary for successful drug evaluation in asthma and COPD', EUROPEAN RESPIRATORY JOURNAL, 42 891-892 (2013) [C3]
DOI10.1183/09031936.00038713Author URL
CitationsScopus - 2Web of Science - 2
2013Jensen ME, Gibson PG, Collins CE, Wood LG, 'Airway and systemic inflammation in obese children with asthma', EUROPEAN RESPIRATORY JOURNAL, 42 1012-1019 (2013) [C1]
DOI10.1183/09031936.00124912Author URL
CitationsScopus - 14Web of Science - 10
Co-authorsClare Collins, Lisa Wood
2013Simpson JL, Gibson PG, Yang IA, Upham J, James A, Reynolds PN, Hodge S, 'Impaired macrophage phagocytosis in non-eosinophilic asthma', CLINICAL AND EXPERIMENTAL ALLERGY, 43 29-35 (2013) [C1]
DOI10.1111/j.1365-2222.2012.04075.xAuthor URL
CitationsScopus - 20Web of Science - 18
Co-authorsJodie Simpson
2013Jensen ME, Gibson PG, Collins CE, Hilton JM, Wood LG, 'Diet-induced weight loss in obese children with asthma: a randomized controlled trial', CLINICAL AND EXPERIMENTAL ALLERGY, 43 775-784 (2013) [C1]
DOI10.1111/cea.12115Author URL
CitationsScopus - 15Web of Science - 14
Co-authorsClare Collins, Lisa Wood
2013Simpson JL, McDonald VM, Baines KJ, Oreo KM, Wang F, Hansbro PM, Gibson PG, 'Influence of Age, Past Smoking, and Disease Severity on TLR2, Neutrophilic Inflammation, and MMP-9 Levels in COPD', MEDIATORS OF INFLAMMATION, (2013) [C1]
DOI10.1155/2013/462934Author URL
CitationsScopus - 6Web of Science - 6
Co-authorsJodie Simpson, Philip Hansbro, Katherine Baines, Vanessa Mcdonald
2013McDonald VM, Higgins I, Gibson PG, 'Managing Older Patients with Coexistent Asthma and Chronic Obstructive Pulmonary Disease Diagnostic and Therapeutic Challenges', DRUGS & AGING, 30 1-17 (2013) [C1]
DOI10.1007/s40266-012-0042-zAuthor URL
CitationsScopus - 8Web of Science - 6
Co-authorsIsabel Higgins, Vanessa Mcdonald
2013Berthon BS, Macdonald-Wicks LK, Gibson PG, Wood LG, 'Investigation of the association between dietary intake, disease severity and airway inflammation in asthma', RESPIROLOGY, 18 447-454 (2013) [C1]
DOI10.1111/resp.12015Author URL
CitationsScopus - 10Web of Science - 9
Co-authorsLesley Wicks, Lisa Wood
2013Vanders RL, Gibson PG, Wark PAB, Murphy VE, 'Alterations in inflammatory, antiviral and regulatory cytokine responses in peripheral blood mononuclear cells from pregnant women with asthma', RESPIROLOGY, 18 827-833 (2013) [C1]
DOI10.1111/resp.12068Author URL
CitationsScopus - 7Web of Science - 4
Co-authorsVanessa Murphy, Peter Wark
2013Brooks CR, Gibson PG, Douwes J, Van Dalen CJ, Simpson JL, 'Relationship between airway neutrophilia and ageing in asthmatics and non-asthmatics', RESPIROLOGY, 18 857-865 (2013) [C1]
DOI10.1111/resp.12079Author URL
CitationsScopus - 8Web of Science - 8
Co-authorsJodie Simpson
2013Vertigan AE, Bone SL, Gibson PG, 'Laryngeal sensory dysfunction in laryngeal hypersensitivity syndrome', RESPIROLOGY, 18 948-956 (2013) [C1]
DOI10.1111/resp.12103Author URL
CitationsScopus - 5Web of Science - 5
2013Porsbjerg CM, Gibson PG, Pretto JJ, Salome CM, Brown NJ, Berend N, King GG, 'Relationship between airway pathophysiology and airway inflammation in older asthmatics', RESPIROLOGY, 18 1128-1134 (2013) [C1]
DOI10.1111/resp.12142Author URL
CitationsScopus - 7Web of Science - 7
2013Scott HA, Gibson PG, Garg ML, Pretto JJ, Morgan PJ, Callister R, Wood LG, 'Dietary restriction and exercise improve airway inflammation and clinical outcomes in overweight and obese asthma: a randomized trial', Clinical and Experimental Allergy, 43 36-49 (2013) [C1]
DOI10.1111/cea.12004Author URL
CitationsScopus - 24Web of Science - 21
Co-authorsLisa Wood, Hayley Scott, Philip Morgan, Robin Callister, Manohar Garg
2013Baines KJ, Hsu AC-Y, Tooze M, Gunawardhana LP, Gibson PG, Wark PAB, 'Novel immune genes associated with excessive inflammatory and antiviral responses to rhinovirus in COPD', RESPIRATORY RESEARCH, 14 (2013) [C1]
DOI10.1186/1465-9921-14-15Author URL
CitationsScopus - 7Web of Science - 8
Co-authorsKatherine Baines, Peter Wark, Alan Hsu
2013Gao P, Simpson JL, Zhang J, Gibson PG, 'Galectin-3: its role in asthma and potential as an anti-inflammatory target', RESPIRATORY RESEARCH, 14 (2013) [C1]
DOI10.1186/1465-9921-14-136Author URL
CitationsScopus - 4Web of Science - 5
Co-authorsJodie Simpson
2013Murphy VE, Wang G, Namazy JA, Powell H, Gibson PG, Chambers C, Schatz M, 'The risk of congenital malformations, perinatal mortality and neonatal hospitalisation among pregnant women with asthma: a systematic review and meta-analysis', BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 120 812-822 (2013) [C1]
DOI10.1111/1471-0528.12224Author URL
CitationsScopus - 13Web of Science - 12
Co-authorsVanessa Murphy
2013Jensen ME, Gibson PG, Collins CE, Hilton JM, Latham-Smith F, Wood LG, 'Increased sleep latency and reduced sleep duration in children with asthma', SLEEP AND BREATHING, 17 281-287 (2013) [C1]
DOI10.1007/s11325-012-0687-1Author URL
CitationsScopus - 5Web of Science - 5
Co-authorsLisa Wood, Clare Collins
2013Fu J-J, Baines KJ, Wood LG, Gibson PG, 'Systemic Inflammation Is Associated with Differential Gene Expression and Airway Neutrophilia in Asthma', OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY, 17 187-199 (2013) [C1]
DOI10.1089/omi.2012.0104Author URL
CitationsScopus - 11Web of Science - 9
Co-authorsLisa Wood, Katherine Baines
2013Gao P, Gibson PG, Zhang J, He X, Hao Y, Li P, Liu H, 'The safety of sputum induction in adults with acute exacerbation of COPD', CLINICAL RESPIRATORY JOURNAL, 7 101-109 (2013) [C1]
DOI10.1111/j.1752-699X.2012.00291.xAuthor URL
CitationsScopus - 3Web of Science - 4
2013Mcdonald VM, Simpson JL, Mcelduff P, Gibson PG, 'Older peoples' perception of tests used in the assessment and management of COPD and asthma', Clinical Respiratory Journal, 7 367-374 (2013) [C1]

Objectives: Outcome assessment is an important part of the management of airways disease, yet older adults may have difficulty with the burden of testing. This study evaluated the patient perception of tests used for the assessment of airways disease in older people. Data Source: Older adults (>55 years) with obstructive airway disease and healthy controls (N=56) underwent inhaler technique assessment, skin allergy testing, venepuncture, fractional exhaled nitric oxide (FENO) and gas diffusion measurement, exercise testing, sputum induction, and questionnaire assessment. They then completed an assessment burden questionnaire across five domains: difficulty, discomfort, pain, symptoms and test duration. Results: Test perception was generally favourable. Induced sputum had the greatest test burden perceived as being more difficult (mean 0.83, P=0.001), associated with more discomfort (mean 1.3, P<0.001), more painful (0.46, P=0.019), longer test duration (0.84, P<0.001) and worsening symptoms (0.55, P=0.001) than the questionnaires. FENO had a more favourable assessment but was assessed to be difficult to perform. Inhaler technique received the most favourable assessment. Conclusions: Older adults hold favourable perceptions to a range of tests that they might encounter in the course of their care for airway disease. The newer tests of sputum induction and FENO have some observed difficulties, in particular sputum induction. The results of this study can inform current practice by including details of the test and its associated adverse effects when conducting the test, as well as providing clear explanations of the utility of tests and how the results might aid in patient care. © 2013 John Wiley & Sons Ltd.

DOI10.1111/crj.12017
Co-authorsJodie Simpson, Vanessa Mcdonald
2013Gao P, Zhang J, He X, Hao Y, Wang K, Gibson PG, 'Sputum Inflammatory Cell-Based Classification of Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease', PLOS ONE, 8 (2013) [C1]
DOI10.1371/journal.pone.0057678Author URL
CitationsScopus - 7Web of Science - 5
2012Wood LG, Garg ML, Smart JM, Scott HA, Barker D, Gibson PG, 'Manipulating antioxidant intake in asthma: A randomized controlled trial', American Journal of Clinical Nutrition, 96 534-543 (2012) [C1]
CitationsScopus - 26Web of Science - 26
Co-authorsHayley Scott, Lisa Wood, Manohar Garg
2012Wood LG, Baines KJ, Fu J, Scott HA, Gibson PG, 'The neutrophilic inflammatory phenotype is associated with systemic inflammation in asthma', Chest, 142 86-93 (2012) [C1]
CitationsScopus - 46Web of Science - 43
Co-authorsHayley Scott, Lisa Wood, Katherine Baines
2012Thorburn AN, Foster PS, Gibson PG, Hansbro PM, 'Components of streptococcus pneumoniae suppress allergic airways disease and NKT cells by inducing regulatory T cells', The Journal of Immunology, 188 4611-4620 (2012) [C1]
CitationsScopus - 23Web of Science - 19
Co-authorsPaul Foster, Philip Hansbro
2012Vanders RL, Wark PA, Murphy VE, Gibson PG, 'Pregnant women have attenuated innate interferon responses to 2009 pandemic influenza a virus subtype H1N1', Journal of Infectious Diseases, 206 646-653 (2012) [C1]
CitationsScopus - 13Web of Science - 12
Co-authorsVanessa Murphy, Peter Wark
2012Chang AB, Yerkovich ST, Gibson PG, Anderson-James S, Petsky HL, Carroll ML, et al., 'Pulmonary innate immunity in children with protracted bacterial bronchitis', Journal of Pediatrics, 161 621-625 (2012) [C1]
CitationsScopus - 10Web of Science - 7
2012Murphy VE, Namazy JA, Powell H, Schatz M, Chambers C, Attia J, Gibson PG, 'A Meta-Analysis of Adverse Perinatal Outcomes in Women With Asthma EDITORIAL COMMENT', OBSTETRICAL & GYNECOLOGICAL SURVEY, 67 77-78 (2012) [C3]
DOI10.1097/OGX.0b013e318247c54dAuthor URL
Co-authorsJohn Attia
2012Pavord ID, Gibson PG, 'Inflammometry: The current state of play', Thorax, 67 191-192 (2012) [C3]
CitationsScopus - 16Web of Science - 16
2012Pavord ID, Gibson PG, 'Use of sputum eosinophil counts to guide management in children with severe asthma [response]', Thorax, 67 1016 (2012) [C3]
CitationsScopus - 1Web of Science - 1
2012Essilfie A-T, Simpson JL, Dunkley ML, Morgan LC, Oliver BG, Gibson PG, et al., 'Combined haemophilus influenzae respiratory infection and allergic airways disease drives chronic infection and features of neutrophilic asthma', Thorax, 67 588-599 (2012) [C1]
CitationsScopus - 32Web of Science - 29
Co-authorsJodie Simpson, Margaret Dunkley, Philip Hansbro, Paul Foster
2012Vanders RL, Gibson PG, Murphy VE, Wark PAB, 'Impaired type I and III interferon response to rhinovirus infection during pregnancy and asthma', Thorax, 67 209-214 (2012) [C1]
CitationsScopus - 28Web of Science - 21
Co-authorsVanessa Murphy, Peter Wark
2012Powell H, Gibson PG, 'Exhaled nitric oxide as a guide to management of asthma in pregnancy Reply', LANCET, 379 708-709 (2012) [C3]
Author URL
2012Powell H, Gibson PG, 'Reply: Exhaled nitric oxide as a guide to management of asthma in pregnancy', Lancet, 379 708-709 (2012) [C3]
2012Powell H, Gibson PG, 'Management of asthma in pregnancy - Authors' reply', The Lancet, 379 e43 (2012) [C3]
2012Ryan NM, Birring SS, Gibson PG, 'Gabapentin for refractory chronic cough: a randomised, double-blind, placebo-controlled trial', The Lancet, 380 1583-1589 (2012) [C1]
CitationsScopus - 55Web of Science - 50
Co-authorsNicole Ryan
2012Vertigan AE, Gibson PG, 'The role of speech pathology in the management of patients with chronic refractory cough', Lung, 190 35-40 (2012) [C1]
CitationsScopus - 7Web of Science - 7
2012Sukkar MB, Wood LG, Tooze MK, Simpson JL, McDonald VM, Gibson PG, Wark PA, 'Soluble RAGE is deficient in neutrophilic asthma and COPD', European Respiratory Journal, 39 721-729 (2012) [C1]
Co-authorsJodie Simpson, Lisa Wood, Peter Wark, Vanessa Mcdonald
2012Wark PA, Tooze M, Cheese L, Whitehead BF, Gibson PG, Wark K, McDonald VM, 'Viral infections trigger exacerbations of cystic fibrosis in adults and children', European Respiratory Journal, 40 510-512 (2012) [C1]
DOI10.1183/09031936.00202311
CitationsScopus - 6Web of Science - 7
Co-authorsPeter Wark, Vanessa Mcdonald
2012Ryan NM, Vertigan AE, Ferguson JK, Wark PA, Gibson PG, 'Clinical and physiological features of postinfectious chronic cough associated with H1N1 infection', Respiratory Medicine, 106 138-144 (2012) [C1]
DOI10.1016/j.rmed.2011.10.007
CitationsScopus - 4Web of Science - 4
Co-authorsPeter Wark, John Ferguson, Nicole Ryan
2012McDonald VM, Gibson PG, 'Exacerbations of severe asthma', Clinical and Experimental Allergy, 42 670-677 (2012) [C1]
CitationsScopus - 12Web of Science - 12
Co-authorsVanessa Mcdonald
2012Wood LG, Gibson PG, 'Adiponectin: The link between obesity and asthma in women?', American Journal of Respiratory and Critical Care Medicine, 186 1-2 (2012) [C3]
CitationsScopus - 5Web of Science - 3
Co-authorsLisa Wood
2012Scott HA, Gibson PG, Garg ML, Pretto JJ, Morgan PJ, Callister R, Wood LG, 'Relationship between body composition, inflammation and lung function in overweight and obese asthma', Respiratory Research, 13 1-10 (2012) [C1]
CitationsScopus - 10Web of Science - 8
Co-authorsLisa Wood, Hayley Scott, Manohar Garg, Robin Callister, Philip Morgan
2012Murphy VE, Namazy JA, Powell H, Schatz M, Chambers C, Attia JR, Gibson PG, 'Severity of asthma in pregnancy affects perinatal outcomes - Authors' Reply', BJOG - An International Journal of Obstetrics and Gynaecology, 119 508-509 (2012) [C3]
DOI10.1111/j.1471-0528.2011.03258.x
Co-authorsVanessa Murphy, John Attia
2012Jensen ME, Wood LG, Gibson PG, 'Obesity and childhood asthma - Mechanisms and manifestations', Current Opinion in Allergy and Clinical Immunology, 12 186-192 (2012) [C1]
CitationsScopus - 23Web of Science - 23
Co-authorsLisa Wood
2011Gibson PG, 'Simple clinical score', Clinical Medicine, 11 96 (2011) [C3]
2011McDonald VM, Higgins I, Simpson JL, Gibson PG, 'The importance of clinical management problems in older people with COPD and asthma: Do patients and physicians agree?', Primary Care Respiratory Journal, 20 389-395 (2011) [C1]

Background: COPD and asthma in older people are complex conditions associated with multiple clinical problems. The relative importance of these problems to both patients and physicians and the level of agreement between them is largely unknown. Methods: Older people with asthma and COPD underwent a multidimensional assessment to characterise the prevalence of clinical problems. Each individual's problems were then summarised and presented separately to the patient and physician to rate problem importance. Problems were scored using a 5-point Likert scale from unimportant to very important. Results: The highest-rated problems were dyspnoea, activity limitation and airway inflammation, and these areas had good patientphysician concordance. Poor concordance was found for inhaler technique adequacy, airflow obstruction and obesity. Good concordance was found for written action plans, but this was less important to both patients and physicians. Conclusions: In asthma and COPD, patients and their physicians agree about the importance of managing activity limitation, dyspnoea, and airway inflammation. Other areas of management had little concordance or were viewed as less important. Self-management skills were not rated as important by patients and this may hinder successful management. Eliciting problems and addressing their importance to treatment goals may improve care in COPD and asthma. © 2011 Primary Care Respiratory Society UK. All rights reserved.

CitationsScopus - 15Web of Science - 13
Co-authorsIsabel Higgins, Jodie Simpson, Vanessa Mcdonald
2011Gibson PG, 'Asthma phenotypes in childhood', Paediatric Respiratory Reviews, 12 151 (2011) [C3]
DOI10.1016/j.prrv.2011.02.006
2011Jensen ME, Collins CE, Gibson PG, Wood LG, 'The obesity phenotype in children with asthma', Paediatric Respiratory Reviews, 12 152-159 (2011) [C1]
DOI10.1016/j.prrv.2011.01.009
CitationsScopus - 17Web of Science - 19
Co-authorsClare Collins, Lisa Wood
2011Essilfie A-T, Simpson JL, Horvat JC, Preston JA, Dunkley ML, Foster PS, et al., 'Haemophilus influenzae infection drives IL-17-mediated neutrophilic allergic airways disease', PLoS Pathogens, 7 e1002244 (2011) [C1]
Co-authorsJodie Simpson, Philip Hansbro, Paul Foster, Margaret Dunkley, Jay Horvat
2011Baines KJ, Simpson JL, Gibson PG, 'Innate immune responses are increased in chronic obstructive pulmonary disease', PLoS ONE, 36 e18426 (2011) [C1]
DOI10.1371/journal.pone.0018426
CitationsScopus - 27Web of Science - 19
Co-authorsJodie Simpson, Katherine Baines
2011McDonald VM, Simpson JL, Higgins IJ, Gibson PG, 'Multidimensional assessment of older people with asthma and COPD: Clinical management and health status', Age and Ageing, 40 42-49 (2011) [C1]
DOI10.1093/ageing/afq134
CitationsScopus - 19Web of Science - 16
Co-authorsVanessa Mcdonald, Isabel Higgins, Jodie Simpson
2011Chang AB, Gibson PG, Willis C, Petsky HL, Widdicombe JG, Masters IB, Robertson CF, 'Do sex and atopy influence cough outcome measurements in children?', Chest, 140 324-330 (2011) [C1]
DOI10.1378/chest.10-2507
CitationsScopus - 4Web of Science - 4
2011Baines KJ, Simpson JL, Wood LG, Scott R, Gibson PG, 'Systemic upregulation of neutrophil a-defensins and serine proteases in neutrophilic asthma', Thorax, 66 942-947 (2011) [C1]
CitationsScopus - 15Web of Science - 15
Co-authorsLisa Wood, Katherine Baines, Rodney Scott, Jodie Simpson
2011Wood LG, Garg ML, Gibson PG, 'A high-fat challenge increases airway inflammation and impairs bronchodilator recovery in asthma', Journal of Allergy and Clinical Immunology, 127 1133-1140 (2011) [C1]
DOI10.1016/j.jaci.2011.01.036
CitationsScopus - 43Web of Science - 36
Co-authorsLisa Wood, Manohar Garg
2011Baines KJ, Simpson JL, Wood LG, Scott R, Gibson PG, 'Transcriptional phenotypes of asthma defined by gene expression profiling of induced sputum samples', Journal of Allergy and Clinical Immunology, 127 153.e9-160.e9 (2011) [C1]
DOI10.1016/j.jaci.2010.10.024
CitationsScopus - 67Web of Science - 55
Co-authorsRodney Scott, Jodie Simpson, Katherine Baines, Lisa Wood
2011Powell GH, Murphy VE, Taylor DR, Hensley MJ, McCaffery K, Giles W, et al., 'Management of asthma in pregnancy guided by measurement of fraction of exhaled nitric oxide: A double-blind, randomised controlled trial', The Lancet, 378 983-990 (2011) [C1]
DOI10.1016/s0140-6736(11)60971-9
CitationsScopus - 96Web of Science - 82
Co-authorsMichael Hensley, Vanessa Murphy
2011Murphy VE, Gibson PG, 'Asthma in pregnancy', Clinics in Chest Medicine, 32 93-110 (2011) [C1]
CitationsScopus - 20Web of Science - 12
Co-authorsVanessa Murphy
2011Powell H, McCaffery K, Murphy VE, Hensley MJ, Clifton VL, Giles WB, Gibson PG, 'Psychosocial outcomes are related to asthma control and quality of life in pregnant women with asthma', Journal of Asthma, 48 1032-1040 (2011) [C1]
DOI10.3109/02770903.2011.631239
CitationsScopus - 19Web of Science - 15
Co-authorsMichael Hensley, Vanessa Murphy
2011Vertigan AE, Gibson PG, 'Chronic refractory cough as a sensory neuropathy: Evidence from a reinterpretation of cough triggers', Journal of Voice, 25 596-601 (2011) [C1]
DOI10.1016/j.jvoice.2010.07.009
CitationsScopus - 30Web of Science - 25
2011Wang F, He XY, Baines KJ, Gunawardhana LP, Simpson JL, Li F, Gibson PG, 'Different inflammatory phenotypes in adults and children with acute asthma', European Respiratory Journal, 38 567-574 (2011) [C1]
DOI10.1183/09031936.00170110
CitationsScopus - 28Web of Science - 25
Co-authorsKatherine Baines, Jodie Simpson
2011Preston JA, Thorburn AN, Starkey MR, Beckett EL, Horvat JC, Wade MA, et al., 'Streptococcus pneumoniae infection suppresses allergic airways disease by inducing regulatory T-cells', European Respiratory Journal, 37 53-64 (2011) [C1]
DOI10.1183/09031936.00049510
CitationsScopus - 31Web of Science - 29
Co-authorsPaul Foster, Malcolm Starkey, Philip Hansbro, Jay Horvat
2011Wang F, Gibson PG, 'Respiratory Chlamydophyla pneumoniae resides primarily in the lower airway', European Respiratory Journal, 38 995 (2011) [C3]
DOI10.1183/09031936.00076011
2011Scott HA, Gibson PG, Garg ML, Wood LG, 'Airway inflammation is augmented by obesity and fatty acids in asthma', European Respiratory Journal, 38 594-602 (2011) [C1]
CitationsScopus - 67Web of Science - 62
Co-authorsLisa Wood, Hayley Scott, Manohar Garg
2011Wood LG, Simpson JL, Wark PA, Powell H, Gibson PG, 'Characterization of innate immune signalling receptors in virus-induced acute asthma', Clinical and Experimental Allergy, 41 640-648 (2011) [C1]
DOI10.1111/j.1365-2222.2010.03669.x
CitationsScopus - 14Web of Science - 13
Co-authorsPeter Wark, Jodie Simpson, Lisa Wood
2011Verrills NM, Irwin JA, He XY, Wood LG, Powell H, Simpson JL, et al., 'Identification of novel diagnostic biomarkers for asthma and chronic obstructive pulmonary disease', American Journal of Respiratory and Critical Care Medicine, 183 1633-1643 (2011) [C1]
DOI10.1164/rccm.201010-1623OC
CitationsScopus - 36Web of Science - 34
Co-authorsAlistair Sim, Vanessa Mcdonald, Lisa Wood, Nikki Verrills, Jodie Simpson
2011Hodyl NA, Stark MJ, Osei-Kumah A, Bowman M, Gibson PG, Clifton VL, 'Fetal glucocorticoid-regulated pathways are not affected by inhaled corticosteroid use for asthma during pregnancy', American Journal of Respiratory and Critical Care Medicine, 183 716-722 (2011) [C1]
DOI10.1164/rccm.201007-1188oc
CitationsScopus - 18Web of Science - 13
Co-authorsMaria Bowman, Vicki Clifton
2011Wood LG, Powell H, Grissell TV, Davies BL, Shafren DR, Whitehead BF, et al., 'Persistence of rhinovirus RNA and IP-10 gene expression after acute asthma', Respirology, 16 291-299 (2011) [C1]
DOI10.1111/j.1440-1843.2010.01897.x
CitationsScopus - 9Web of Science - 9
Co-authorsLisa Wood, Michael Hensley
2011McDonald VM, Vertigan AE, Gibson PG, 'How to set up a severe asthma service', Respirology, 16 900-911 (2011) [C1]
DOI10.1111/j.1440-1843.2011.02012.x
CitationsScopus - 4Web of Science - 4
Co-authorsVanessa Mcdonald
2011Thomas R, Ferguson JK, Coombs G, Gibson PG, 'Community-acquired methicillin-resistant Staphylococcus aureus pneumonia: A clinical audit', Respirology, 16 926-931 (2011) [C1]
CitationsScopus - 11Web of Science - 10
Co-authorsJohn Ferguson
2011Vertigan AE, Gibson PG, 'Urge to cough and its application to the behavioural treatment of cough', Bratislavske Lekarske Listy, 112 102-108 (2011) [C1]
CitationsScopus - 3Web of Science - 4
2011Gibson PG, Ryan NM, 'Cough pharmacotherapy: Current and future status', Expert Opinion on Pharmacotherapy, 12 1745-1755 (2011) [C1]
CitationsScopus - 12Web of Science - 10
Co-authorsNicole Ryan
2011Murphy VE, Namazy JA, Powell H, Schatz M, Chambers C, Attia JR, Gibson PG, 'A meta-analysis of adverse perinatal outcomes in women with asthma', BJOG: An International Journal of Obstetrics and Gynaecology, 118 1314-1323 (2011) [C1]
DOI10.1111/j.1471-0528.2011.03055.x
CitationsScopus - 66Web of Science - 56
Co-authorsVanessa Murphy, John Attia
2010Ryan NM, Vertigan AE, Bone S, Gibson PG, 'Cough reflex sensitivity improves with speech language pathology management of refractory chronic cough', Cough, 6 1-8 (2010) [C1]
CitationsScopus - 19
Co-authorsNicole Ryan
2010Wood LG, Gibson PG, 'Reduced circulating antioxidant defences are associated with airway hyper-responsiveness, poor control and severe disease pattern in asthma', British Journal of Nutrition, 103 735-741 (2010) [C1]
DOI10.1017/s0007114509992376
CitationsScopus - 14Web of Science - 16
Co-authorsLisa Wood
2010Barnes PJ, Dweik RA, Gelb AF, Gibson PG, George SC, Grasemann H, et al., 'Exhaled nitric oxide in pulmonary diseases: A comprehensive review', Chest, 138 682-692 (2010) [C1]
DOI10.1378/chest.09-2090
CitationsScopus - 152Web of Science - 137
2010Horvat JC, Starkey MR, Kim RY, Beagley KW, Preston JA, Gibson PG, et al., 'Chlamydial respiratory infection during allergen sensitization drives neutrophilic allergic airways disease', Journal of Immunology, 184 4159-4169 (2010) [C1]
DOI10.4049/jimmunol.0902287
CitationsScopus - 40Web of Science - 35
Co-authorsJay Horvat, Malcolm Starkey, Philip Hansbro, Paul Foster
2010Li J, Wang W, Baines KJ, Bowden NA, Hansbro PM, Gibson PG, et al., 'IL-27/IFN-y induce MyD88-dependent steroid-resistant airway hyperresponsiveness by inhibiting glucocorticoid signaling in macrophages', Journal of Immunology, 185 4401-4409 (2010) [C1]
DOI10.4049/jimmunol.1001039
CitationsScopus - 35Web of Science - 32
Co-authorsPaul Foster, Philip Hansbro, Katherine Baines, Nikola Bowden, Ming Yang
2010Gibson PG, Chang AB, Glasgow NJ, Holmes PW, Katelaris P, Kemp AS, et al., 'CICADA: Cough in children and adults: Diagnosis and assessment. Australian Cough Guidelines summary statement', Medical Journal of Australia, 192 265-271 (2010) [C2]
CitationsScopus - 32Web of Science - 28
2010Gibson PG, Chang AB, Kemp AS, 'CICADA: Cough in Children and Adults: Diagnosis and Assessment. Australian Cough Guidelines summary statement REPLY', Medical Journal of Australia, 192 672 (2010) [C3]
2010Thorburn AN, O'Sullivan BJ, Thomas R, Kumar RK, Foster PS, Gibson PG, Hansbro PM, 'Pneumococcal conjugate vaccine-induced regulatory T cells suppress the development of allergic airways disease', Thorax, 65 1053-1060 (2010) [C1]
DOI10.1136/thx.2009.131508
CitationsScopus - 29Web of Science - 28
Co-authorsPhilip Hansbro, Paul Foster
2010Murphy VE, Clifton VL, Gibson PG, 'The effect of cigarette smoking on asthma control during exacerbations in pregnant women', Thorax, 65 739-744 (2010) [C1]
DOI10.1136/thx.2009.124941
CitationsScopus - 21Web of Science - 17
Co-authorsVicki Clifton, Vanessa Murphy
2010Hodyl NA, Wyper HJ, Osei-Kumah A, Scott NM, Murphy VE, Gibson PG, et al., 'Sex-specific associations between cortisol and birth weight in pregnancies complicated by asthma are not due to differential glucocorticoid receptor expression', Thorax, 65 677-683 (2010) [C1]
DOI10.1136/thx.2009.123091
CitationsScopus - 16Web of Science - 12
Co-authorsVanessa Murphy, Roger Smith, Vicki Clifton
2010Horvat JC, Starkey MR, Kim RY, Phipps S, Gibson PG, Beagley KW, et al., 'Early-life chlamydial lung infection enhances allergic airways disease through age-dependent differences in immunopathology', Journal of Allergy and Clinical Immunology, 125 617-625 (2010) [C1]
DOI10.1016/j.jaci.2009.10.018
Co-authorsJay Horvat, Paul Foster, Malcolm Starkey, Philip Hansbro
2010Gibson PG, McDonald VM, Marks GB, 'Asthma in older adults', The Lancet, 376 803-813 (2010) [C1]
DOI10.1016/S0140-6736(10)61087-2
CitationsScopus - 111Web of Science - 90
Co-authorsVanessa Mcdonald
2010Baines KJ, Simpson JL, Bowden NA, Scott R, Gibson PG, 'Differential gene expression and cytokine production from neutrophils in asthma phenotypes', European Respiratory Journal, 35 522-531 (2010) [C1]
DOI10.1183/09031936.00027409
CitationsScopus - 30Web of Science - 24
Co-authorsJodie Simpson, Nikola Bowden, Rodney Scott, Katherine Baines
2010Wood LG, Attia JR, McElduff P, McEvoy MA, Gibson PG, 'Assessment of dietary fat intake and innate immune activation as risk factors for impaired lung function', European Journal of Clinical Nutrition, 64 818-825 (2010) [C1]
DOI10.1038/ejcn.2010.68
CitationsScopus - 5Web of Science - 5
Co-authorsLisa Wood, John Attia
2010Reddel HK, Gibson PG, Peters MJ, Wark PA, Sand IB, Hoyos CM, Jenkins CR, 'Down-titration from high-dose combination therapy in asthma: Removal of long-acting b2-agonist', Respiratory Medicine, 104 1110-1120 (2010) [C1]
DOI10.1016/j.rmed.2010.04.003
CitationsScopus - 32Web of Science - 26
Co-authorsPeter Wark
2010Wood LG, Simpson JL, Hansbro PM, Gibson PG, 'Potentially pathogenic bacteria cultured from the sputum of stable asthmatics are associated with increased 8-isoprostane and airway neutrophilia', Free Radical Research, 44 146-154 (2010) [C1]
DOI10.3109/10715760903362576
CitationsScopus - 23Web of Science - 18
Co-authorsPhilip Hansbro, Jodie Simpson, Lisa Wood
2010Wood LG, Powell HG, Gibson PG, 'Mannitol challenge for assessment of airway responsiveness, airway inflammation and inflammatory phenotype in asthma', Clinical & Experimental Allergy, 40 232-241 (2010) [C1]
DOI10.1111/j.1365-2222.2009.03371.x
CitationsScopus - 18Web of Science - 15
Co-authorsLisa Wood
2009Boyd M, Lasserson TJ, McKean MC, Gibson PG, Ducharme FM, Haby M, 'Interventions for educating children who are at risk of asthma-related emergency department attendance', Cochrane Database of Systematic Reviews, - CD001290 (2009) [C1]
DOI10.1002/14651858.cd001290.pub2
CitationsScopus - 39Web of Science - 26
2009Walters JAE, Gibson PG, Wood-Baker R, Hannay M, Walters EH, 'Systemic corticosteroids for acute exacerbations of chronic obstructive pulmonary disease', Cochrane Database of Systematic Reviews, - CD001288 (2009) [C1]
DOI10.1002/14651858.cd001288.pub3
CitationsScopus - 72Web of Science - 35
2009Thorburn AN, Hansbro PM, Gibson PG, 'Pneumococcal vaccines for allergic airways diseases', Expert Opinion on Biological Therapy, 9 621-629 (2009) [C1]
DOI10.1517/14712590902916999
CitationsScopus - 14Web of Science - 12
Co-authorsPhilip Hansbro
2009Baines KJ, Wood LG, Gibson PG, 'The nutrigenomics of asthma: Molecular mechanisms of airway neutrophilia following dietary antioxidant withdrawal', OMICS: A Journal of Integrative Biology, 13 355-365 (2009) [C1]
DOI10.1089/omi.2009.0042
CitationsScopus - 13Web of Science - 11
Co-authorsKatherine Baines, Lisa Wood
2009Ryan NM, Vertigan AE, Gibson PG, 'Chronic cough and laryngeal dysfunction improve with specific treatment of cough and paradoxical vocal fold movement', Cough, 5 1-8 (2009) [C1]
DOI10.1186/1745-9974-5-4
CitationsScopus - 9
Co-authorsNicole Ryan
2009Gibson PG, 'Inflammatory phenotypes in adult asthma: clinical applications', CLINICAL RESPIRATORY JOURNAL, 3 198-206 (2009) [C3]
DOI10.1111/j.1752-699X.2009.00162.xAuthor URL
CitationsScopus - 42Web of Science - 34
2009Krishnan JA, Davis SQ, Naureckas ET, Gibson PG, Rowe BH, 'An umbrella review: Corticosteroid therapy for adults with acute asthma', American Journal of Medicine, 122 977-991 (2009) [C1]
DOI10.1016/j.amjmed.2009.02.013
CitationsScopus - 19Web of Science - 18
2009Clifton VL, Engel PJ, Smith R, Gibson PG, Brinsmead MW, Giles WB, 'Maternal and neonatal outcomes of pregnancies complicated by asthma in an Australian population', Australian and New Zealand Journal of Obstetrics and Gynaecology, 49 619-626 (2009) [C1]
DOI10.1111/j.1479-828x.2009.01077.x
CitationsScopus - 26Web of Science - 25
Co-authorsRoger Smith
2009Saedi Some Olia A, Wood LG, Garg ML, Gibson PG, Wark PA, 'Anti-inflammatory effects of long-chain n-3 PUFA in rhinovirus-infected cultured airway epithelial cells', British Journal of Nutrition, 101 533-540 (2009) [C1]
DOI10.1017/s0007114508025798
CitationsScopus - 14Web of Science - 11
Co-authorsLisa Wood, Manohar Garg, Peter Wark
2009Ryan NM, Gibson PG, 'Characterization of laryngeal dysfunction in chronic persistent cough', Laryngoscope, 119 640-645 (2009) [C1]
DOI10.1002/lary.20114
CitationsScopus - 11Web of Science - 11
Co-authorsNicole Ryan
2009Marks GB, Poulos LM, Jenkins CR, Gibson PG, 'Asthma in older adults: A holistic, person-centred and problem-oriented approach', Medical Journal of Australia, 191 197-199 (2009) [C3]
CitationsScopus - 6Web of Science - 5
2009Simpson JL, McElduff P, Gibson PG, 'Assessment and reproducibility of non-eosinophilic asthma using induced sputum', Respiration, 79 147-151 (2009) [C1]
DOI10.1159/000245899
CitationsScopus - 28Web of Science - 27
Co-authorsJodie Simpson
2009Gibson PG, Simpson JL, 'The overlap syndrome of asthma and COPD: What are its features and how important is it?', Thorax, 64 728-735 (2009) [C1]
DOI10.1136/thx.2008.108027
CitationsScopus - 185Web of Science - 145
Co-authorsJodie Simpson
2009Gibson PG, 'Tackling asthma phenotypes in community studies', Thorax, 64 369-370 (2009) [C3]
DOI10.1136/thx.2008.109710
CitationsScopus - 4Web of Science - 4
2009Wood LG, Gibson PG, 'Dietary factors lead to innate immune activation in asthma', Pharmacology and Therapeutics, 123 37-53 (2009) [C1]
DOI10.1016/j.pharmthera.2009.03.015
CitationsScopus - 30Web of Science - 29
Co-authorsLisa Wood
2009Simpson JL, Phipps S, Gibson PG, 'Inflammatory mechanisms and treatment of obstructive airway diseases with neutrophilic bronchitis', Pharmacology and Therapeutics, 124 86-95 (2009) [C1]
DOI10.1016/j.pharmthera.2009.06.004
CitationsScopus - 42Web of Science - 38
Co-authorsJodie Simpson
2009Wood LG, Scott HA, Garg ML, Gibson PG, 'Innate immune mechanisms linking non-esterified fatty acids and respiratory disease', Progress in Lipid Research, 48 27-43 (2009) [C1]
DOI10.1016/j.plipres.2008.10.001
CitationsScopus - 23Web of Science - 18
Co-authorsHayley Scott, Lisa Wood, Manohar Garg
2009Baines KJ, Simpson JL, Scott R, Gibson PG, 'Immune responses of airway neutrophils are impaired in asthma', Experimental Lung Research, 35 554-569 (2009) [C1]
DOI10.1080/01902140902777490
CitationsScopus - 14Web of Science - 15
Co-authorsRodney Scott, Jodie Simpson, Katherine Baines
2009Simpson JL, Baines KJ, Boyle MJ, Scott R, Gibson PG, 'Oncostatin M (OSM) is increased in asthma with incompletely reversible airflow obstruction', Experimental Lung Research, 35 781-794 (2009) [C1]
DOI10.3109/01902140902906412
CitationsScopus - 9Web of Science - 11
Co-authorsRodney Scott, Jodie Simpson, Katherine Baines
2009Simpson JL, Milne DG, Gibson PG, 'Neutrophilic asthma has different radiographic features to COPD and smokers', Respiratory Medicine, 103 881-887 (2009) [C1]
DOI10.1016/j.rmed.2008.12.013
CitationsScopus - 13Web of Science - 12
Co-authorsJodie Simpson
2009Gibson PG, 'Using fractional exhaled nitric oxide to guide asthma therapy: Design and methodological issues for ASthma TReatment ALgorithm studies', Clinical and Experimental Allergy, 39 478-490 (2009) [C1]
DOI10.1111/j.1365-2222.2009.03226.x
CitationsScopus - 61Web of Science - 58
2009Saedi Some Olia A, Wood LG, Garg ML, Gibson PG, Wark PA, 'Lycopene enrichment of cultured airway epithelial cells decreases the inflammation induced by rhinovirus infection and lipopolysaccharide', Journal of Nutritional Biochemistry, 20 577-585 (2009) [C1]
DOI10.1016/j.jnutbio.2008.06.001
CitationsScopus - 27Web of Science - 25
Co-authorsLisa Wood, Peter Wark, Manohar Garg
2009Reddel HK, Taylor DR, Bateman ED, Boulet L-P, Boushey HA, Busse WW, et al., 'An official American Thoracic Society/European Respiratory Society Statement: Asthma control and exacerbations standardising endpoints for clinical asthma trials and clinical practice', American Journal of Respiratory and Critical Care Medicine, 180 59-99 (2009) [C1]
DOI10.1164/rccm.200801-060st
CitationsScopus - 545Web of Science - 491
2009Vandemheen KL, O'Connor A, Bell SC, Freitag A, Bye P, Jeanneret A, et al., 'Randomized trial of a decision aid for patients with cystic fibrosis considering lung transplantation', American Journal of Respiratory and Critical Care Medicine, 180 761-768 (2009) [C1]
DOI10.1164/rccm.200903-0421oc
CitationsScopus - 16Web of Science - 19
2009Gibson PG, Vertigan AE, 'Speech pathology for chronic cough: A new approach', Pulmonary Pharmacology & Therapeutics, 22 159-162 (2009) [C1]
DOI10.1016/j.pupt.2008.11.005
CitationsScopus - 20Web of Science - 12
2009Widdicombe J, Fontana G, Gibson PG, 'Workshop - Cough: Exercise, speech and music', Pulmonary Pharmacology & Therapeutics, 22 143-147 (2009) [C3]
DOI10.1016/j.pupt.2008.12.009
CitationsWeb of Science - 4
2009Wark PA, Grissell TV, Davies BL, See HV, Gibson PG, 'Diversity in the bronchial epithelial cell response to infection with different rhinovirus strains', Respirology, 14 180-186 (2009) [C1]
DOI10.1111/j.1440-1843.2009.01480.x
CitationsScopus - 41Web of Science - 38
Co-authorsPeter Wark
2008Saedi Some Olia A, Wood LG, Garg ML, Gibson PG, Wark PA, 'Supplementation of long chain N-3 polyunsaturated fatty acids increases the utilization of lycopene in cultured airway epithelial cells', Journal of Food Lipids, 15 421-432 (2008) [C1]
DOI10.1111/j.1745-4522.2008.00130.x
CitationsScopus - 5Web of Science - 3
Co-authorsManohar Garg, Lisa Wood, Peter Wark
2008Wood LG, Garg ML, Powell H, Gibson PG, 'Lycopene-rich treatments modify noneosinophilic airway inflammation in asthma: Proof of concept', Free Radical Research, 42 94-102 (2008) [C1]
DOI10.1080/10715760701767307
CitationsScopus - 37Web of Science - 38
Co-authorsManohar Garg, Lisa Wood
2008Simpson JL, Powell H, Boyle MJ, Scott R, Gibson PG, 'Clarithromycin targets neutrophilic airway inflammation in refractory asthma', American Journal of Respiratory and Critical Care Medicine, 177 148-155 (2008) [C1]
DOI10.1164/rccm.200707-1134oc
CitationsScopus - 223Web of Science - 178
Co-authorsRodney Scott, Jodie Simpson
2008Wlodarczyk JH, Gibson PG, Caeser M, 'Impact of inhaled corticosteroids on cortisol suppression in adults with asthma: A quantitative review', Annals of Allergy, Asthma and Immunology, 100 23-30 (2008) [C1]
DOI10.1016/S1081-1206(10)60400-0
CitationsScopus - 13Web of Science - 10
2008McDonald VM, Gibson PG, 'Asthma mortality and management in older Australians: Time for a new approach?', Australasian Journal on Ageing, 27 215 (2008) [C3]
DOI10.1111/j.1741-6612.2008.00322.x
CitationsScopus - 4Web of Science - 3
Co-authorsVanessa Mcdonald
2008Manning P, Gibson PG, Lasserson TJ, 'Ciclesonide versus other inhaled steroids for chronic asthma in children and adults', Cochrane Database of Systematic Reviews, CD007031 (2008) [C1]
DOI10.1002/14651858.cd007031
CitationsScopus - 15Web of Science - 8
2008Manning P, Gibson PG, Lasserson TJ, 'Ciclesonide versus placebo for chronic asthma in adults and children', Cochrane Database of Systematic Reviews, CD006217 (2008) [C1]
DOI10.1002/14651858.cd006217.pub2
CitationsScopus - 3Web of Science - 6
2008Ryan NM, Gibson PG, 'Extrathoracic airway hyperresponsiveness as a mechanism of post infectious cough: Case report', Cough, 4 1-4 (2008) [C3]
DOI10.1186/1745-9974-4-7
CitationsScopus - 7
Co-authorsNicole Ryan
2008Vertigan AE, Gibson PG, Theodoros DG, Winkworth AL, 'The role of sensory dysfunction in the development of voice disorders, chronic cough and paradoxical vocal fold movement', International Journal of Speech-Language Pathology, 10 231-244 (2008) [C1]
DOI10.1080/17549500801932089
CitationsScopus - 5Web of Science - 4
2008Powell H, Smart JM, Wood LG, Grissell TV, Shafren DR, Hensley MJ, Gibson PG, 'Validity of the common cold questionnaire (CCQ) in asthma exacerbations', PLoS ONE, 3 e1802 (2008) [C1]
DOI10.1371/journal.pone.0001802
Co-authorsLisa Wood, Michael Hensley
2008Marchant JM, Gibson PG, Grissell TV, Timmins NL, Masters IB, Chang AB, 'Prospective assessment of protracted bacterial bronchitis: Airway inflammation and innate immune activation', Pediatric Pulmonology, 43 1092-1099 (2008) [C1]
DOI10.1002/ppul.20906
CitationsScopus - 33Web of Science - 25
2008Gibson PG, 'A light at the end of the tunnel of inflammation in obstructive airway diseases?', Chest, 134 475-476 (2008) [C3]
DOI10.1378/chest.08-1478
2008Pavord ID, Shaw DE, Gibson PG, Taylor DR, 'Inflammometry to assess airway diseases', The Lancet, 372 1017-1019 (2008) [C3]
DOI10.1016/s0140-6736(08)61421-x
CitationsScopus - 35Web of Science - 32
2008Wood LG, Garg ML, Blake RJ, Simpson JL, Gibson PG, 'Oxidized vitamin E and glutathione as markers of clinical status in asthma', Clinical Nutrition, 27 579-586 (2008) [C1]
DOI10.1016/j.clnu.2007.12.002
CitationsScopus - 17Web of Science - 14
Co-authorsJodie Simpson, Lisa Wood, Manohar Garg
2008Murphy VE, Gibson PG, 'Premenstrual asthma: Prevalence, cycle-to-cycle variability and relationship to oral contraceptive use and menstrual symptoms', Journal of Asthma, 45 696-704 (2008) [C1]
DOI10.1080/02770900802207279
CitationsScopus - 16Web of Science - 11
Co-authorsVanessa Murphy
2008Vertigan AE, Theodoros DG, Winkworth AL, Gibson PG, 'A comparison of two approaches to the treatment of chronic cough: Perceptual, acoustic, and electroglottographic outcomes', Journal of Voice, 22 581-589 (2008) [C1]
DOI10.1016/j.jvoice.2007.01.001
CitationsScopus - 6Web of Science - 7
2008Taylor DR, Bateman ED, Boulet LP, Boushey HA, Busse WW, Casale TB, et al., 'A new perspective on concepts of asthma severity and control', European Respiratory Journal, 32 545-554 (2008) [C1]
DOI10.1183/09031936.00155307
CitationsScopus - 195Web of Science - 169
2008Bateman ED, Hurd SS, Barnes PJ, Bousquet J, Drazen JM, Fitzgerald M, et al., 'Global strategy for asthma management and prevention: GINA executive summary', European Respiratory Journal, 31 143-178 (2008) [C1]
DOI10.1183/09031936.00138707
CitationsScopus - 1160Web of Science - 998
2008Vertigan AE, Theodoros DG, Winkworth AL, Gibson PG, 'Acoustic and electroglottographic voice characteristics in chronic cough and paradoxical vocal fold movement', Folia Phoniatrica et Logopaedica, 60 210-216 (2008) [C1]
DOI10.1159/000136902
CitationsScopus - 5Web of Science - 6
2007Vertigan AE, Theodoros DG, Gibson PG, Winkworth AL, 'Voice and Upper Airway Symptoms in People With Chronic Cough and Paradoxical Vocal Fold Movement', Journal of Voice, 21 361-383 (2007) [C1]
DOI10.1016/j.jvoice.2005.12.008
CitationsScopus - 19Web of Science - 18
2007Chang AB, Gibson PG, Ardill J, McGarvey LPA, 'Calcitonin gene-related peptide relates to cough sensitivity in children with chronic cough', European Respiratory Journal, 30 66-72 (2007) [C1]
DOI10.1183/09031936.00150006
CitationsScopus - 16
2007Lovett CJ, Whitehead BF, Gibson PG, 'Eosinophilic airway inflammation and the prognosis of childhood asthma', Clinical and Experimental Allergy, 37 1594-1601 (2007) [C1]
DOI10.1111/j.1365-2222.2007.02839.x
CitationsScopus - 19Web of Science - 15
2007Vertigan AE, Theodoros DG, Winkworth AL, Gibson PG, 'Perceptual voice characteristics in chronic cough and paradoxical vocal fold movement', Folia Phoniatrica et Logopaedica, 59 256-267 (2007) [C1]
DOI10.1159/000104464
CitationsScopus - 12Web of Science - 13
2007Vertigan AE, Theodoros DG, Winkworth AL, Gibson PG, 'Chronic cough: A tutorial for speech-language pathologists', Journal of Medical Speech-Language Pathology, 15 189-206 (2007) [C1]
CitationsScopus - 6Web of Science - 6
2007Horvat JC, Beagley KW, Wade MA, Preston JA, Hansbro NG, Hickey DK, et al., 'Neonatal chlamydial infection induces mixed T-cell responses that drive allergic airway disease', American Journal of Respiratory and Critical Care Medicine, 176 556-564 (2007) [C1]
DOI10.1164/rccm.200607-1005OC
CitationsScopus - 45Web of Science - 44
Co-authorsJay Horvat, Nicole Hansbro, Philip Hansbro, Paul Foster
2007Weckmann M, Collison A, Simpson JL, Kopp MV, Wark PA, Smyth MJ, et al., 'Critical link between TRAIL and CCL20 for the activation of T(H)2 cells and the expression of allergic airway disease', Nature Medicine, 13 1308-1315 (2007) [C1]
DOI10.1038/nm1660
CitationsScopus - 61Web of Science - 59
Co-authorsPaul Foster, Peter Wark, Joerg Mattes, Nicole Hansbro, Jodie Simpson
2007Gibson PG, Taramarcaz P, McDonald VM, 'Use of omalizumab in a severe asthma clinic', Respirology, 12 S35-S44 (2007) [C1]
DOI10.1111/j.1440-1843.2007.01047.x
CitationsScopus - 5Web of Science - 2
Co-authorsVanessa Mcdonald
2007Grissell TV, Chang AB, Gibson PG, 'Reduced toll-like receptor 4 and substance P gene expression is associated with airway bacterial colonization in children', Pediatric Pulmonology, 42 380-385 (2007) [C1]
DOI10.1002/ppul.20592
CitationsScopus - 22
2007Vertigan AE, Theodoros DG, Gibson PG, Winkworth AL, 'Behaviour modification therapies for chronic cough', Chronic Respiratory Disease, 4 89-97 (2007) [C1]
DOI10.1177/1479972307078099
CitationsScopus - 9
2007Gibson PG, Abramson M, Wood-Baker R, Volmink J, Hensley M, Costabel U, 'Evidence-based Respiratory Medicine', Evidence-based Respiratory Medicine, 1-593 (2007)

First major evidence-based text in adult respiratory medicine. Comprehensive, authoritative summary of the best treatments for the major respiratory diseases. Compiled by specialists from the Cochrane Airways Management Group. Easy-to-use format, with key clinical implications summarised in each chapter. Kept up-to-date online: Compiled by specialists from the Cochrane Collaboration Airways Management Group, Evidence-based Respiratory Medicine is the first major evidence-based text in adult respiratory medicine. Providing a comprehensive summary of the best treatments for the most important respiratory diseases, some of the world's leading physicians review the evidence for a broad range of treatments using evidence-based principles. Essential information is presented in an easy-to-understand format, with the most important clinical implications summarised in each chapter. Evidence-based Respiratory Medicine tackles the big clinical questions in diagnosis and treatment, presenting treatment options which take into account the individual patient's needs. Evidence-Based Series:Evidence-based Respiratory Medicine, part of the acclaimed series BMJ Evidence-based medicine textbooks that have revolutionised clinical medicine literature, comes with a fully searchable CD-ROM of the whole text. Note: CD-ROM/DVD and other supplementary materials are not included as part of eBook file. © 2005 by Blackwell Publishing Ltd.

DOI10.1002/9780470987377
2007Vertigan AE, Gibson PG, Theodoros DG, Winkworth AL, 'A review of voice and upper airway function in chronic cough and paradoxical vocal cord movement', Current Opinion in Allergy and Clinical Immunology, 7 37-42 (2007) [C1]
DOI10.1097/ACI.0b013e328012c587
CitationsScopus - 8Web of Science - 6
2007Gibson PG, 'Long-Term Oxygen Therapy for Chronic Respiratory Failure in Chronic Obstructive Pulmonary Disease 463-471 (2007)
DOI10.1002/9780470987377.ch35
CitationsScopus - 1
2007Gibson PG, Powell H, 'Asthma Education 183-191 (2007)
DOI10.1002/9780470987377.ch14
2007Wood LG, Powell HG, Grissell TV, Nguyen TTD, Shafren D, Hensley MJ, Gibson PG, 'Persistent airway obstruction after virus infection is not associated with airway inflammation', Chest, 131 415-423 (2007) [C1]
DOI10.1378/chest.06-1062
CitationsScopus - 8Web of Science - 7
Co-authorsLisa Wood, Michael Hensley
2007Simpson JL, Grissell TV, Douwes J, Scott R, Boyle MJ, Gibson PG, 'Innate immune activation in neutrophilic asthma and bronchiectasis', Thorax, 62 211-218 (2007) [C1]
DOI10.1136/thx.2006.061358
CitationsScopus - 131Web of Science - 120
Co-authorsJodie Simpson, Rodney Scott
2007Gibson PG, 'What do non-eosinophilic asthma and airway remodelling tell us about persistent asthma?', Thorax, 62 1034-1036 (2007) [C3]
CitationsScopus - 6Web of Science - 5
2007Gibson PG, Powell H, Ducharme FM, 'Differential effects of maintenance long-acting beta-agonist and inhaled corticosteroid on asthma control and asthma exacerbations', Journal of Allergy and Clinical Immunology, 119 344-350 (2007) [C1]
DOI10.1016/j.jaci.2006.10.043
CitationsScopus - 59Web of Science - 53
2007Gibson PG, Ducharme FM, Cates CJ, 'Reply', Journal of Allergy and Clinical Immunology, 120 726 (2007) [C3]
DOI10.1016/j.jaci.2007.04.043
2007Wark PA, Bucchieri F, Johnston SL, Gibson PG, Hamilton L, Mimica J, et al., 'IFN-gamma-induced protein 10 is a novel biomarker of rhinovirus-induced asthma exacerbations', Journal of Allergy and Clinical Immunology, 120 586-593 (2007) [C1]
DOI10.1016/j.jaci.2007.04.046
CitationsScopus - 82Web of Science - 78
Co-authorsJohn Attia, Joanna Latter, Peter Wark
2007Yang Z, Yan WX, Cai H, Tedla N, Armishaw C, Di Girolamo N, et al., 'S100A12 provokes mast cell activation: A potential amplification pathway in asthma and innate immunity', Journal of Allergy and Clinical Immunology, 119 106-114 (2007) [C1]
DOI10.1016/j.jaci.2006.08.021
CitationsScopus - 53Web of Science - 55
Co-authorsJodie Simpson
2007Gibson PG, Ducharme FM, Cates CJ, 'Benefits of long-acting beta(2)-agonists - Reply', Journal of Allergy and Clinical Immunology, 120 726 (2007) [C3]
2007Preston JA, Essilfie AT, Horvat JC, Wade MA, Beagley KW, Gibson PG, et al., 'Inhibition of allergic airways disease by immunomodulatory therapy with whole killed Streptococcus pneumoniae', Vaccine, 25 8154-8162 (2007) [C1]
DOI10.1016/j.vaccine.2007.09.034
CitationsScopus - 28Web of Science - 27
Co-authorsJay Horvat, Philip Hansbro, Paul Foster
2006Wood LG, Gibson PG, Garg ML, 'A review of the methodology for assessing in vivo antioxidant capacity', Journal of the Science of Food and Agriculture, 86 2057-2066 (2006) [C1]
DOI10.1002/jsfa.2604
CitationsScopus - 49Web of Science - 38
Co-authorsManohar Garg, Lisa Wood
2006Murphy VE, Clifton VL, Gibson PG, 'Asthma exacerbations during pregnancy: incidence and association with adverse pregnancy outcomes', Thorax, 61 169-176 (2006) [C1]
DOI10.1136/thx.2005.049718
CitationsScopus - 113Web of Science - 101
Co-authorsVanessa Murphy, Vicki Clifton
2006Wark PA, Gibson PG, 'Asthma exacerbations 3: Pathogenesis', Thorax, 61 909-915 (2006) [C1]
DOI10.1136/thx.2005.045187
CitationsScopus - 59Web of Science - 51
Co-authorsPeter Wark
2006Fitzgerald JM, Gibson PG, 'Asthma exacerbations 4: Prevention', Thorax, 61 992-999 (2006) [C1]
DOI10.1136/thx.2005.045195
CitationsScopus - 33Web of Science - 23
2006Vertigan A, Theodoros D, Gibson PG, Winkworth A, 'Efficacy of Speech pathology management for chronic cough: a randomised placebo controllled trial of treatment efficacy', Thorax, 61 1065-1069 (2006) [C1]
DOI10.1136/thx.2006.064337
CitationsScopus - 55Web of Science - 39
2006Vertigan AE, Theodoros DG, Gibson PG, Winkworth AL, 'The Relationship Between Chronic Cough and Paradoxical Vocal Fold Movement: A Review of the Literature', Journal of Voice, 20 466-480 (2006) [C1]
DOI10.1016/j.jvoice.2005.08.001
CitationsScopus - 23Web of Science - 20
2006Simpson JL, Scott R, Boyle MJ, Gibson PG, 'Inflammatory subtypes in asthma: Assessment and identification using induced sputum', Respirology, 11 54-61 (2006) [C1]
DOI10.1111/j.1440-1843.2006.00784.x
CitationsScopus - 245Web of Science - 223
Co-authorsRodney Scott, Jodie Simpson
2006Murphy VE, Johnson RF, Wang YC, Akinsanya K, Gibson PG, Smith R, Clifton VL, 'Proteomic study of plasma proteins in pregnant women with asthma', Respirology, 11 41-48 (2006) [C1]
DOI10.1111/j.1440-1843.2006.00782.x
CitationsScopus - 19Web of Science - 18
Co-authorsRoger Smith, Vanessa Murphy, Vicki Clifton
2006Vm M, Gibson PG, 'Asthma self-management education', Chronic Respiratory Disease, 3 29-37 (2006) [C1]
DOI10.1191/1479972306cd090ra
CitationsScopus - 22
Co-authorsVanessa Mcdonald
2006Vertigan AE, Gibson PG, Theodoros DG, Winkworth AL, Borgas T, Reid C, 'Involuntary glottal closure during inspiration in muscle tension dysphonia', Laryngoscope, 116 643-649 (2006) [C1]
DOI10.1097/01.MLG.0000201906.41316.FC
CitationsScopus - 7Web of Science - 7
2006Johnston S, Blasi F, Black P, Martin R, Farrell D, Nieman R, et al., 'The effect of telithromycin in acute exacerbations of asthma', The New England Journal of Medicine, 354 1589-1600 (2006) [C1]
DOI10.1056/NEJMoa044080
2006Gibson PG, 'Allergic bronchopulmonary aspergillosis', Seminars in Respiratory and Critical Care Medicine, 27 185-191 (2006) [C1]
DOI10.1055/s-2006-939521
CitationsScopus - 36Web of Science - 31
2006Gibson PG, Powell H, 'Initial corticosteroid therapy for asthma', Current Opinion in Pulmonary Medicine, 12 48-53 (2006) [C1]
DOI10.1097/01.mcp.0000199808.64882.12
CitationsScopus - 4Web of Science - 2
2005Thakkinstian A, McEvoy MA, Minelli C, Gibson PG, Hancox B, Duffy D, et al., 'Systematic review and meta-analysis of the association between beta(2)-adrenoceptor polymorphisms and asthma: A HuGE review', American Journal of Epidemiology, 162 201-211 (2005) [C1]
DOI10.1093/aje/kwi184
CitationsScopus - 223Web of Science - 221
Co-authorsJohn Attia
2005Wood LG, Gibson PG, Garg ML, 'Circulating markers to assess nutritional therapy in cystic fibrosis', Clinica Chimica Acta, 353 13-29 (2005) [C1]
DOI10.1016/j.cccn.2004.11.002
CitationsScopus - 7Web of Science - 6
Co-authorsLisa Wood, Manohar Garg
2005Thomas PS, Gibson PG, Wang H, Shah S, Henry RL, 'The relationship of exhaled nitric oxide to airway inflammation and responsiveness in children', Journal of Asthma, 42 291-295 (2005) [C1]
DOI10.1081/JAS-200057908
CitationsScopus - 28Web of Science - 27
2005Wood LG, Garg ML, Blake RJ, Garcia-Caraballo S, Gibson PG, 'Airway and Circulating Levels of Carotenoids in Asthma and Healthy Controls', Journal of the American College of Nutrition, 24 448-455 (2005) [C1]
CitationsScopus - 34Web of Science - 29
Co-authorsManohar Garg, Lisa Wood
2005Gibson PG, 'Teaching old drugs new tricks: Asthma therapy adjusted by patient perception or noninvasive markers', EUROPEAN RESPIRATORY JOURNAL, 25 397-399 (2005)
DOI10.1183/09031936.05.00002805Author URL
CitationsScopus - 17Web of Science - 12
2005Murphy VE, Gibson PG, Smith R, Clifton VL, 'Asthma during pregnancy: mechanisms and treatment implications', European Respiratory Journal, 25 731-750 (2005) [C1]
DOI10.1183/09031936.05.00085704
CitationsScopus - 79Web of Science - 65
Co-authorsRoger Smith, Vanessa Murphy, Vicki Clifton
2005Murphy VE, Gibson PG, Talbot PI, Kessell CG, Clifton VL, 'Asthma self-management skills and the use of asthma education during pregnancy', European Respiratory Journal, 26 435-441 (2005) [C1]
DOI10.1183/09031936.05.00135604
CitationsScopus - 43Web of Science - 32
Co-authorsVanessa Murphy, Vicki Clifton
2005Clifton VL, Crompton R, Read MA, Gibson PG, Smith R, Wright IM, 'Microvascular Effects of Corticotropin-Releasing Hormone in Human Skin Vary in Relation to Estrogen Concentration During the Menstrual Cycle', Journal of Endocrinology, 186 69-76 (2005) [C1]
DOI10.1677/joe.1.06030
CitationsScopus - 14Web of Science - 11
Co-authorsIan Wright, Roger Smith, Vicki Clifton
2005Simpson JL, Gibson PG, 'Deficient Sputum Anti-Protease Defenses in Neutrophilic and Eosinophilic Asthma', INFLAMMATION RESEARCH, 54 S136-S137 (2005)
Author URL
Co-authorsJodie Simpson
2005Bains KJ, Bell NV, Simpson JL, Scott RJ, Boyle MJ, Gibson PG, 'Enhanced IL-8 Release front Neutrophils in Non-Eosinophilic Asthma', INFLAMMATION RESEARCH, 54 S137-S137 (2005)
Author URL
Co-authorsRodney Scott, Jodie Simpson
2005Murphy VE, Johnson RF, Wang Y-C, Akinsanya K, Gibson PG, Smith R, Clifton VL, 'The Effect of Maternal Asthma on Placental and Cord Blood Protein Profiles', Society for Gynecological Investigation Journal, 12 349-355 (2005) [C1]
DOI10.1016/j.jsgi.2005.01.024
CitationsScopus - 16Web of Science - 15
Co-authorsVicki Clifton, Vanessa Murphy, Roger Smith
2005McDonald VM, Gibson PG, 'Inhalation-device polypharmacy in asthma', Medical Journal of Australia, 182 250-251 (2005) [C3]
CitationsScopus - 7Web of Science - 7
Co-authorsVanessa Mcdonald
2005Simpson JL, Wood LG, Gibson PG, 'Inflammatory mediators in exhaled breath, induced sputum and saliva', Clinical & Experimental Allergy, 35 1180-1185 (2005) [C1]
DOI10.1111/j.1365-2222.2005.02327.x
CitationsScopus - 40Web of Science - 38
Co-authorsJodie Simpson, Lisa Wood
2005Simpson JL, Scott R, Boyle MJ, Gibson PG, 'Differential proteolytic enzyme activity in eosinophilic and neutrophilic asthma', American Journal of Respiratory and Critical Care Medicine, 172 559-565 (2005) [C1]
DOI10.1164/rccm.200503-369OC
CitationsScopus - 94Web of Science - 85
Co-authorsRodney Scott, Jodie Simpson
2005Wood LG, Garg ML, Simpson JL, Mori TA, Croft KD, Wark PA, Gibson PG, 'Induced sputum 8-isoprostane concentrations in inflammatory airway diseases', American Journal of Respiratory and Critical Care Medicine, 171 426-430 (2005) [C1]
DOI10.1164/rccm.200408-1010OC
CitationsScopus - 56Web of Science - 50
Co-authorsJodie Simpson, Peter Wark, Manohar Garg, Lisa Wood
2005Gibson PG, Powell H, Ducharme F, 'Long-acting beta2-agonists as an inhaled corticosteroid-sparing agent for chronic asthma in adults and children.', Cochrane database of systematic reviews (Online), (2005)

BACKGROUND: The addition of a long acting beta agonist (LABA) to inhaled corticosteroid (ICS) therapy can improve asthma symptoms and reduce exacerbations. The addition of LABA may also have an ICS-sparing effect and permit a reduction in ICS maintenance dose. OBJECTIVES: To determine the efficacy of adding LABA to maintenance ICS therapy in reducing the requirement for ICS while maintaining control of chronic asthma. SEARCH STRATEGY: We searched the Cochrane Airways Group trials register and reference lists of articles. Date of last search: November 2004 SELECTION CRITERIA: Parallel RCTs that compared reduced dose ICS in combination with LABA vs ICS alone in asthmatics requiring daily ICS. DATA COLLECTION AND ANALYSIS: Trial quality was assessed and data were extracted independently by two reviewers. Study authors were contacted for confirmation. Trials were analysed according to the following ICS dose comparisons: a fixed moderate/high dose or a reduced/tapering dose of the same ICS. MAIN RESULTS: 19 publications describing 10 trials of adults were included in the review. Studies that compared reduced dose (mean 60% reduction) ICS/LABA combination to a fixed moderate/high dose ICS found no significant difference in severe exacerbations requiring oral corticosteroids (RR 1.0, 95%CI 0.76 to 1.32), withdrawal due to worsening asthma (RR 0.82, 95%CI 0.5 to 1.35) or airway inflammation. There were also significant improvements in FEV1 (change from baseline WMD 0.10, 95%CI 0.07 to 0.12), morning & evening PEF and percent rescue free days with LABA. Two studies provided outcomes for a reduced/tapering ICS dose comparison. More participants receiving the LABA/reduced ICS combination achieved a reduction in ICS dose reaching significance in one study. A significant reduction of 253 mcg BDP was achieved in one study. AUTHORS' CONCLUSIONS: In adults with asthma, using moderate to high maintenance doses of ICS, the addition of LABA has an ICS-sparing effect. The addition ofLABA permits more participants on minimum maintenance ICS to reduce ICS. The precise magnitude of the ICS dose reduction requires further study.

CitationsScopus - 8
2005Murphy VE, Gibson PG, Talbot PI, Clifton VL, 'Severe asthma exacerbations during pregnancy', Obstetrics and Gynecology, 106 1046-1054 (2005) [C1]
Co-authorsVanessa Murphy, Vicki Clifton
2004Powell HG, Gibson PG, 'Initial starting dose of inhaled corticosteroids in adults with asthma: a systematic review', Thorax, 59 1041-1045 (2004) [C1]
DOI10.1136/thx.2004.023754
CitationsScopus - 28Web of Science - 16
2004Gibson PG, Powell HG, 'Written action plans for asthma: an evidence-based review of the key components', Thorax, 59 94-99 (2004) [C1]
DOI10.1136/thorax.2003.011858
CitationsScopus - 206Web of Science - 157
2004Gibson PG, 'Atopic cough', Thorax, 59 449 (2004) [C3]
CitationsScopus - 2Web of Science - 3
2004Douwes J, Le Gros G, Gibson PG, Pearce N, 'Can bacterial endotoxin exposure reverse atopy and atopic disease?', Journal of Allergy and Clinical Immunology, 114 1051-1054 (2004) [C1]
DOI10.1016/j.jaci.2004.08.004
CitationsScopus - 48Web of Science - 37
2004Taramarcaz P, Grissell TV, Borgas T, Gibson PG, 'Transient postviral vocal cord dysfunction', The Journal of Allergy and Clinical Immunology, 114 1471-1472 (2004) [C1]
DOI10.1016/j.jaci.2004.08.038
CitationsWeb of Science - 19
2004Hansbro PM, Beagley KW, Horvat JC, Gibson PG, 'Role of atypical bacterial infection of the lung in predisposition/protection of asthma', Pharmacology and Therapeutics, 101 193-210 (2004) [C1]
DOI10.1016/j.pharmthera.2003.10.007
CitationsScopus - 63Web of Science - 54
Co-authorsJay Horvat, Philip Hansbro
2004Preston JA, Beagley KW, Gibson PG, Hansbro PM, 'Genetic background affects susceptibility in nonfatal pneumococcal bronchopneumonia', Eur Respir J, 23 224-231 (2004) [C1]
DOI10.1183/09031936.03.00081403
CitationsScopus - 19Web of Science - 16
Co-authorsPhilip Hansbro
2004Gibson PG, Simpson JL, Holgate ST, Dahlén S-E, Reid DW, Champion A, et al., 'The European Network For Understanding Mechanisms Of Severe Asthma study; Host response to transmissible Pseudomonas aeruginosa; The use of computer-animation programs during spirometry in preschool children', European Respiratory Journal, 23 492-495 (2004)
DOI10.1183/09031936.04.00132904
Co-authorsJodie Simpson
2004Simpson JL, Timmins N, Fakes K, Talbot P, Gibson PG, 'Effect of saliva contamination on induced sputum cell counts, IL-8 and eosinophil cationic protein levels', European Respiratory Journal, 23 759-762 (2004) [C1]
DOI10.1183/09031936.04.00043104a
CitationsScopus - 14Web of Science - 12
Co-authorsJodie Simpson
2004Gibson PG, Simpson JL, 'The European Network For Understanding Mechanisms Of Severe Asthma study', European Respiratory Journal, 23 492-495 (2004) [C1]
DOI10.1183/09031936.04.00132904a
CitationsScopus - 2Web of Science - 2
Co-authorsJodie Simpson
2004Taramarcaz P, Gibson PG, 'The effectiveness of intranasal corticosteroids in combined allergic rhinitis and asthma syndrome', Clinical and Experimental Allergy, 34 1883-1889 (2004) [C1]
DOI10.1111/j.1365-2222.2004.02130.x
CitationsScopus - 28Web of Science - 20
2004Gibson PG, 'Review: Regular inhaled short acting B[sub2]- agonistimprove lung function in stable chronic obstructive pulmonary disease: commentary', ACP Journal Club, 140 12 (2004) [C3]
2004Gibson PG, 'Cough is an airway itch?', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 169 1-2 (2004)
DOI10.1164/rccm.2310009Author URL
CitationsScopus - 13Web of Science - 12
2004Gibson PG, 'Cough is an Airway Itch', American Journal of Respiratory and Critical Care Medicine, 169 1-9 (2004) [C3]
2004Gibson PG, 'Smokers and ex-smokers with chronic stable asthma did not respond to high dose oral corticosteroids', Evidence Based Medicine, 9 115 (2004) [C3]
2004Powell H, Gibson PG, Thien F, 'Review: Adults who require inhaled corticosteroids benefit from a moderate starting dose', Evidence-Based Medicine, 9 178-178 (2004)
DOI10.1136/ebm.9.6.178
2004Gibson PG, 'Asthma action plans: use it or lose it', Primary Care Respiratory Journal, 13 17-18 (2004) [C3]
CitationsScopus - 7
2004Henry RL, Gibson PG, Vimpani GV, Francis JL, Hazell J, 'Randomized Controlled Trial of a Teacher-Led Asthma Education Program', Pediatric Pulmonology, 38 434-442 (2004) [C1]
DOI10.1002/ppul.20095
CitationsScopus - 23Web of Science - 18
2003Powell H, Gibson PG, 'Review: Regular medical review is equivalent to written self management plans for optimising asthma control in adults', Evidence-Based Medicine, 8 115-115 (2003)
DOI10.1136/ebm.8.4.115
2003Simpson JL, Moric I, Wark PA, Johnston S, Gibson PG, 'Use of induced sputum for the diagnosis of influenza and infections in asthma: a comparison of diagnostic techniques', Journal of Clinical Virology, 339-346 (2003) [C1]
DOI10.1016/S1386-6532(02)00084-7
CitationsScopus - 30Web of Science - 25
Co-authorsJodie Simpson, Peter Wark
2003Hensley MJ, Chalmers AC, Clover K, Gibson PG, Toneguzzi R, Lewis PR, 'Symptoms of Asthma: Comparison of a Parent-Completed Retrospective Questionnaire With a Prospective Daily Symptom Diary', Pediatric Pulmonology, 36 509-513 (2003) [C1]
DOI10.1002/ppul.10360
CitationsScopus - 19Web of Science - 18
Co-authorsMichael Hensley, Anita Chalmers
2003Gibson PG, Henry RL, Shah S, Powell H, Wang H, 'Migration to a Western Country Increases Asthma Symptoms But Not Eosinophilic Airway Inflammation', Pediatric Pulmonology, 36 209-215 (2003) [C1]
DOI10.1002/ppul.10323
CitationsScopus - 33Web of Science - 30
2003Powell H, Gibson PG, 'Options for self-management education for adults with asthma.', Cochrane database of systematic reviews (Online), (2003)

BACKGROUND: Asthma education and self-management are key recommendations of asthma management guidelines because they improve health outcomes. There are several different modalities for the delivery of asthma self-management education. OBJECTIVES: We evaluated programmes that: 1) Optimised asthma control through inhaled corticosteroid use by regular medical review or optimised asthma control by individualised written action plans 2) Used written self-management plans based on peak expiratory flow self-monitoring compared with symptom self-monitoring 3) Compared different options for the delivery of optimal self-management programmes. SEARCH STRATEGY: We searched the Cochrane Airways Group trials register and reference lists of articles. SELECTION CRITERIA: Randomised trials of asthma self-management education interventions in adults over 16 years of age with asthma. DATA COLLECTION AND ANALYSIS: Fifteen trials met the inclusion criteria. Trial quality was assessed and data were extracted independently by two reviewers. Study authors were contacted for confirmation. MAIN RESULTS: 1) Six studies compared optimal self-management allowing self-adjustment of medications according to an individualised written action plan to adjustment of medications by a doctor. These two styles of asthma management gave equivalent effects for hospitalisation, ER visits, unscheduled doctor visits and nocturnal asthma. 2) Self-management using a written action plan based on PEF was found to be equivalent to self-management using a symptoms based written action plan in the six studies which compared these interventions. 3) Three studies compared self-management options. In one, that provided optimal therapy but tested the omission of regular review, the latter was associated with more health centre visits and sickness days. In another, comparing high and low intensity education, the latter was associated with more unscheduled doctor visits. In a third, no difference in health care utilisation or lung function was reported between verbal instruction and written action plans. REVIEWER'S CONCLUSIONS: Optimal self-management allowing for optimisation of asthma control by adjustment of medications may be conducted by either self-adjustment with the aid of a written action plan or by regular medical review. Individualised written action plans based on peak expiratory flow are equivalent to action plans based on symptoms. Reducing the intensity of self-management education or level of clinical review may reduce its effectiveness.

2003Powell H, Gibson PG, 'Inhaled corticosteroid doses in asthma: an evidence-based approach', The Medical Journal of Australia, 178 223-225 (2003) [C1]
CitationsScopus - 67Web of Science - 54
2003Gibson PG, Simpson JL, Hankin RG, Powell HG, Henry RL, 'Relationship between included sputum eosinophils and clinical pattern of childhood asthma', Thorax, 58 116-121 (2003) [C1]
DOI10.1136/thorax.58.2.116
CitationsScopus - 69Web of Science - 54
Co-authorsJodie Simpson
2003Wark PA, Hensley MJ, Saltos N, Boyle MJ, Toneguzzi R, Simpson JL, et al., 'Anti-inflammatory effect of itraconazole in stable allergic bronchopulmonary aspergillosis: A randomized controlled trial', The Journal of Allergy and Clinical Immunology, 111 952-957 (2003) [C1]
DOI10.1067/mai.2003.1388
CitationsScopus - 144Web of Science - 111
Co-authorsPeter Wark, Jodie Simpson, Michael Hensley
2003Chang AB, Gibson PG, Masters I, Dash P, Hills B, 'The Relationship Between Inflammation and Dipalmitoyl Phosphatidycholine in Induced Sputum of Children with Asthma', Journal of Asthma, 40 63-70 (2003) [C1]
DOI10.1081/JAS-120017208
CitationsScopus - 4Web of Science - 3
2003Gibson PG, Wark PA, Simpson JL, Meldrum CJ, Meldrum S, Saltos N, Boyle MJ, 'Induced sputum IL-8 gene expression, neutrophil influx and MMP-9 in allergic bronchopulmonary aspergillosis', European Respiratory Journal, 21 582-588 (2003) [C1]
DOI10.1183/09031936.03.00001803
CitationsScopus - 37Web of Science - 28
Co-authorsPeter Wark, Jodie Simpson
2003Wood LG, Gibson PG, Garg ML, 'Exhaled breath condensate contains more than only volatiles', The European Respiratory Journal, 22 1 (2003) [C3]
CitationsScopus - 5
Co-authorsManohar Garg, Lisa Wood
2003Gibson PG, Ram FSF, Powell H, 'Asthma Education', Respiratory Medicine, 97 1036-1044 (2003) [C1]
DOI10.1016/S0954-6111(03)00134-3
CitationsScopus - 42Web of Science - 31
2003Gibson PG, 'Respiratory rehabilitation improves health-related quality of life in chronic obstructive pulmonary disease', ACP Journal Club, 138 43 (2003) [C3]
2003Murphy VE, Gibson PG, Giles WB, Zakar T, Smith R, Bisits AM, et al., 'Maternal Asthma Is Associated with Reduced Female Fetal Growth', American Journal of Respiratory & Critical Care Medicine, 168 1317-1323 (2003) [C1]
DOI10.1164/rccm.200303-374OC
CitationsScopus - 126Web of Science - 116
Co-authorsVicki Clifton, Roger Smith, Vanessa Murphy
2003Wark PAB, Gibson PG, 'Clinical Usefulness of Inflammatory Markers in Asthma', American Journal of Respiratory & Critical Care Medicine, 2 11-19 (2003) [C1]
CitationsScopus - 22
2003Rutherford C, Mills R, Gibson PG, Price MJ, 'Improvement in health-related quality of life with fluticasone propionate compared with budesonide or beclomethasone dipropionate in adults with severe asthma', Respirology, 8 371-375 (2003) [C1]
DOI10.1046/j.1440-1843.2003.00488.x
CitationsScopus - 11Web of Science - 9
2002Murphy VE, Zakar T, Smith R, Giles WB, Gibson PG, Clifton VL, 'Reduced 11 -Hydroxysteroid Dehydrogenase Type 2 Activity Is Associated with Decreased Birth Weight Centile in Pregnancies Complicated by Asthma', The Journal of Clinical Endocrinology & Metabolism, 87(4) 1660-1668 (2002) [C1]
CitationsScopus - 90Web of Science - 86
Co-authorsRoger Smith, Vanessa Murphy, Vicki Clifton
2002Gibson PG, 'Should we still give our asthmatic patients written individualised management plans? Comment', MEDICAL JOURNAL OF AUSTRALIA, 177 460-460 (2002)
Author URL
2002Thornett AM, Newbury JW, Duszynski AJ, Gibson PG, 'Should we still give our asthmatic patients written individualised management plans? (multiple letters)', Medical Journal of Australia, 177 459-460 (2002)
CitationsScopus - 1
2002Gibson PG, 'Comment: Should we still give our asthmatic patients written individualised management plans?', The Medical Journal of Australia, 177(8) 460 (2002) [C3]
2002Douwes J, Gibson PG, Pekkanen J, Pearce N, 'Non-eosinophilic asthma: importance and possible mechanisms', Thorax, 57 643-648 (2002) [C1]
CitationsWeb of Science - 272
2002Gibson PG, Fujimura M, Niimi A, 'Eosinophilic bronchitis: clinical manifestations and implications for treatment', Thorax, 57(2) 178-182 (2002) [C1]
CitationsScopus - 118
2002Wark PA, Johnston S, Simpson JL, Hensley MJ, Gibson PG, 'Chlamydia pneumoniae immunoglobulin A reactivation and airway inflammation in acute asthma', The European Respiratory Journal, 20 834-840 (2002) [C1]
CitationsScopus - 50Web of Science - 42
Co-authorsMichael Hensley, Peter Wark, Jodie Simpson
2002Wark PA, Johnston S, Moric I, Simpson JL, Hensley MJ, Gibson PG, 'Neutrophil degranulation and cell lysis is associated with clinical severity in virus-induced asthma', The European Respiratory Journal, 19 68-75 (2002) [C1]
CitationsScopus - 203Web of Science - 179
Co-authorsPeter Wark, Jodie Simpson, Michael Hensley
2002Gibson PG, Grootendor D, Henry R, Pin I, Rytila P, Wark P, et al., 'Sputum induction in children', European Respiratory Journal, 37 44s-46s (2002) [C3]
CitationsScopus - 23Web of Science - 4
2002Wark PA, Simpson JL, Hensley MJ, Gibson PG, 'Airway inflammation in thunderstorm asthma', Clinical and Experimental Allergy, 32 1750-1756 (2002) [C1]
CitationsScopus - 27Web of Science - 21
Co-authorsJodie Simpson, Peter Wark, Michael Hensley
2002Mamoon H, Henry R, Stuart JE, Gibson PG, 'House dust mite allergen levels in carpeted sleeping accommodation are higher in private houses than public places', Journal of Paediatrics and Child Health, 38 568-570 (2002) [C1]
CitationsScopus - 7Web of Science - 4
Co-authorsJohn Stuart
2002Gibson PG, Coughlan J, Wilson A, Hensley MJ, Abramson M, Bauman A, Walters E, 'Limited (information only) patient education programs for adults with asthma', The Cochrane Library, 2 CD001005 (2002) [C3]
CitationsScopus - 13
Co-authorsMichael Hensley, Amanda Wilson
2002Richeldi L, Ferrara G, Fabbri L, Gibson PG, 'Macrolides for chronic asthma', The Cochrane Library, 1 CD002997 (2002) [C3]
2002Haby M, Waters E, Robertson C, Gibson PG, Ducharme F, 'Interventions for educating children who have attended the emergency room for asthma', The Cochrane Library, 1 CD001290 (2002) [C3]
2002Walters E, Walters J, Gibson PG, 'Regular treatment with long acting beta agonists versus daily regular treatment with short acting beta agonists in adults and children with stable asthma', The Cochrane Library, 4 CD003901 (2002) [C3]
2002Gibson PG, 'Outpatient monitoring of asthma', Current Opinion in Allergy and Clinical Immunology, 2 161-166 (2002) [C1]
CitationsScopus - 7
2002Preston JA, Beagley KW, Gibson PG, Hansbro PM, 'Development of a Pneumococcal Pneumonia Recovery Model in Mice', 3rd International Symposium on Pneumococci and Pneumococcal Diseases, n/a 91 (2002) [C3]
Co-authorsPhilip Hansbro
2002Gibson PG, Powell H, Coughlan J, Wilson AJ, Hensley MJ, Abramson M, et al., 'Limited (information only) patient education programs for adults with asthma.', Cochrane database of systematic reviews (Online), (2002)

BACKGROUND: A key component of many asthma management guidelines is the recommendation for patient education and regular medical review. A number of controlled trials have been conducted to measure the effectiveness of asthma education programmes. These programmes improve patient knowledge, but their impact on health outcomes is less well established. At its simplest level, education is limited to the transfer of information about asthma, its causes and its treatment. This review focused on the effects of limited asthma education. OBJECTIVES: The objective of this review was to assess the effects of limited (i.e. information only) asthma education on health outcomes in adults with asthma. SEARCH STRATEGY: We searched the Cochrane Airways Group trials register and reference lists of articles. SELECTION CRITERIA: Randomised and controlled trials of individual asthma education involving information transfer only in adults over 16 years of age. DATA COLLECTION AND ANALYSIS: Trial quality was assessed and two reviewers extracted data independently. Study authors were contacted for missing information. MAIN RESULTS: Twelve trials were included. They were of variable quality. Limited asthma education did not reduce hospitalisation for asthma (weighted mean difference -0.03 average hospitalisations per person per year, 95% confidence interval -0.09 to 0.03). There was no significant effect on doctor visits, lung function and medication use. The effects on asthma symptoms were variable. There was no reduction in days lost from normal activity, but in two studies, perceived asthma symptoms did improve after limited asthma education (odds ratio 0.44, 95% confidence interval 0.26 to 0.74). In one study, limited asthma education was associated with reduced emergency department visits (reduction of -2.76 average visits per person per year, 95% confidence interval -4.34 to 1.18). REVIEWER'S CONCLUSIONS: Use of limited asthma education as it has been practiced does not appear to improve health outcomes in adults with asthma although perceived symptoms may improve. Provision of information in the emergency department may be effective, but this needs to be confirmed.

CitationsScopus - 58
2002Chang A, Gibson PG, 'Relationship between Cough, Cough Receptor Sensitivity and Asthma in Children', Pulmonary Pharmacology & Therapeutics, 15 287-291 (2002) [C1]
CitationsScopus - 10Web of Science - 5
2002Simpson JL, Gibson PG, Wark PA, 'Optimization of sputum-processing methods for the measurement of interleukin-5: Effects of protease inhibition', Respirology, 7 111-116 (2002) [C1]
CitationsScopus - 8Web of Science - 10
Co-authorsPeter Wark, Jodie Simpson
2002Wood LG, Fitzgerald DA, Gibson PG, Cooper DM, Garg ML, 'Increased plasma fatty acid concentrations after respiratory exacerbations are associated with elevated oxidative stress in cystic fibrosis patients', American Journal of Clinical Nutrition: a journal reporting the practical application of our world-wide knowledge of nutrition, 75 668-675 (2002) [C1]
CitationsScopus - 33Web of Science - 30
Co-authorsLisa Wood, Manohar Garg
2002Chang A, Harrhy V, Simpson JL, Masters I, Gibson PG, 'Cough, airway inflammation, and mild asthma exacerbation', Archives of Disease in Childhood, 86 270-275 (2002) [C1]
CitationsScopus - 22Web of Science - 22
Co-authorsJodie Simpson
2002Powell H, Gibson PG, 'Teaching People about Asthma: the evidence', International Review of Asthma, 4(4) 88-101 (2002) [C3]
2001Gibson PG, Simpson J, Saltos N, 'Heterogeneity of Airway Inflammation in Persistant Asthma Evidence of Neturophilic Inflammation and Increased Sputum Interleukin-8', Chest, 119 1329-1336 (2001) [C1]
CitationsScopus - 320Web of Science - 279
Co-authorsJodie Simpson
2001Gibson PG, 'Implementing evidence-based guidelines', Medical Journal of Australia, 174 337-338 (2001) [C2]
CitationsScopus - 8Web of Science - 6
2001Coughlan JD, Gibson PG, Henry R, 'Medical treatment for reflux oesophagitis does not consistently improve asthma control: a systematic review', Thorax, 56 198-204 (2001) [C1]
CitationsScopus - 69
2001Gibson PG, 'Gastro-oesophageal reflux and asthma - author's reply', Thorax, 56(11) 898 (2001) [C3]
2001Jujimura M, Gibson PG, 'Eosinophilic airway diseases with isolated cough except for asthma', Japanese Journal of Clinical Medicine, 59 2031-2038 (2001) [C3]
2001Gibson PG, 'Management of chronic obstructive pulmonary disease (COPD)', Australian Prescriber, 24 152-155 (2001)

The expiratory airflow obstruction that characterises chronic obstructive pulmonary disease is usually progressive over time and caused by emphysema, obliterative bronchiolitis, and mucus hypersecretion. Stopping smoking is the only measure that slows the progression of chronic obstructive pulmonary disease, and smokers should be encouraged to stop at all stages of the disease. The effects of medication are limited, and need to be balanced against cost and adverse effects. Bronchodilators, given by puffer and spacer rather than by nebuliser, are effective. Avoid inhaled corticosteroids unless there is associated asthma. Pulmonary rehabilitation leads to important improvements in quality of life. Influenza vaccination is helpful. Comorbidity from cardiac disease and sleep disordered breathing are common and can be effectively treated. New therapies under evaluation include lung volume reduction surgery, non-invasive ventilation, and anti-inflammatory drugs.

2001Gibson PG, 'Outcomes of the Cochrane Airways Group International Conference', Australian Prescriber, 24 78-79 (2001) [C3]
2001Wood L, Fitzgerald D, Gibson PG, Cooper D, Collins C, Garg M, 'Oxidative Stress in Cystic Fibrosis: Dietary and Metabolic Factors', Journal of the American College of Nutrition, 20 157-165 (2001) [C1]
CitationsScopus - 60Web of Science - 49
Co-authorsClare Collins, Lisa Wood, Manohar Garg
2001Wark PA, Simpson J, Hensley MJ, Gibson PG, 'Safety of sputum induction with isotonic saline in adults with acute severe asthma', Clinical and Experimental Allergy, 31 1745-1753 (2001) [C1]
CitationsScopus - 27Web of Science - 23
Co-authorsJodie Simpson, Michael Hensley, Peter Wark
2001Shah S, Peat J, Mazurski E, Wang H, Sindhusake D, Bruce C, et al., 'Effect of peer led programme for asthma education in adolescents: cluster randomised controlled trial', BMJ, 322 1-5 (2001) [C1]
2001Gibson PG, Shah S, Sindhausake D, Wang H, Peat J, Henry R, 'Peer led programme for athma education in adolescents - Author's Reply', BMJ, 323(7304) 110 (2001) [C3]
2001Shah S, Peat JK, Mazurski EJ, Wang H, Sindhusake D, Bruce C, et al., 'Effect of peer led programme for asthma education in adolescents: cluster randomised controlled trial', BRITISH MEDICAL JOURNAL, 322 583-585 (2001)
DOI10.1136/bmj.322.7286.583Author URL
CitationsScopus - 120Web of Science - 94
2001Gibson PG, Shah S, Sindhusake D, Wang H, Peak JK, Henry RL, 'Peer led programme for asthma education in adolescents - Reply', BRITISH MEDICAL JOURNAL, 323 111-111 (2001)
Author URL
2001Jones PD, Hankin RG, Simpson J, Gibson PG, Henry R, 'The Tolerability, Safety, and Success of Sputum Induction and Combined Hypertonic Saline Challenge in Children', American Journal of Respiratory And Critical Care Medicine, 164 1146-1149 (2001) [C1]
CitationsScopus - 42Web of Science - 31
Co-authorsJodie Simpson
2001Gibson PG, Saltos N, Fakes K, 'Acute Anti-Inflammatory Effects of Inhaled Budesonide in Asthma. A randomized controlled trial', American Journal of Respiratory and Critical Care Medicine, 163 32-36 (2001) [C1]
CitationsScopus - 116Web of Science - 96
2001Gibson PG, Simpson J, Chalmers AC, Toneguzzi R, Wark PA, Wilson AJ, Hensley MJ, 'Airway Eosinophilia is associated with Wheeze but is uncommon in Children with Persistent Cough and Frequent Chest Colds', American Journal of Respiratory and Critical Care Medicine, 164 977-981 (2001) [C1]
CitationsScopus - 43Web of Science - 35
Co-authorsAnita Chalmers, Amanda Wilson, Michael Hensley, Jodie Simpson, Peter Wark
2001Clifton VL, Giles WB, Smith R, Bisits AM, Hempenstall P, Kessell C, Gibson PG, 'Alterations of Placental Vascular Function in Asthmatic Pregnancies', American Journal of Respiratory and Critical Care Medicine, 164 546-553 (2001) [C1]
CitationsScopus - 44Web of Science - 36
Co-authorsRoger Smith, Vicki Clifton
2001Wark PA, Gibson PG, Johnston S, 'Exacerbations of asthma: addressing the triggers and treatments', Monaldi Archives for Chest Disease, 56 429-435 (2001) [C1]
Co-authorsPeter Wark
2001Arnold DJ, Gibson PG, 'Prevalence of long term oral corticosteroid use and treatment for osteoporosis in chronic obstructive pulmonary disease (copd) or asthma', Respirology, 6 (2001)

Aim: To determine the prevalence of long term (>6 months) oral corticosteroid use and osteoporosis therapy (treatment or prevention) in patients hospitalised with COPD or asthma. Method: All patients admitted to hospital under the care of the respiratory service with a history of COPD or asthma were interviewed to assess their use of OCS, history of osteoporosis and therapy for osteoporosis. Results: 67 patients (mean±SD age 63±17) were enrolled, 48 with COPD and 19 with asthma. 19(28%) were on long term OCS and of these 7(10%) had a previous diagnosis of osteoporosis (5 had had a fracture and all were on osteoporosis therapy; 2 had had no fracture and 1 was on therapy). Of the 12( 18%) patients on long term OCS with no diagnosis of osteoporosis none were on preventative therapy. Of 48 patients not on long term OCS 8 had a previous diagnosis of osteoporosis but only 3 were on therapy. Overall 27 (40%) of 67 patients were on long term OCS or had a previous diagnosis of osteoporosis, 13 (19%) had had a fracture and 11 ( 16%) were on osteoporosis treatment. Conclusion: Amongst patients admitted to hospital with COPD or asthma use of long term OCS or history of osteoporosis is common, while therapy for prevention or treatment of osteoporosis is uncommon.

2001Wark PA, Gibson PG, 'Allergic bronchopulmonary aspergillosis: New concepts of pathogenesis and treatment', Respirology, 6 1-7 (2001) [C2]
CitationsScopus - 49
Co-authorsPeter Wark
2001Berend N, Kellett B, Kent N, Sly P, Bowler S, Burdon J, et al., 'Improved safety with equivalent asthma control in adults with chronic severe asthma on high-dose fli\uticasone propionate', Respirology, 6 237-246 (2001) [C1]
2001Preston JA, Beagley KW, Gibson PG, Hansbro PM, 'Effects of Infections by Streptococcus pneumoniae on Eosinophilic Immune Responses', Official Journal of the Australian Society for Microbiology, 22 A82 (2001) [C3]
Co-authorsPhilip Hansbro
2001Wark P, Wilson AW, Gibson PG, 'Azoles for allergic bronchopulmonary aspergillosis associated with asthma.', Cochrane database of systematic reviews (Online), (2001)

BACKGROUND: Allergic Broncho-pulmonary Aspergillosis is hypersensitivity to the fungus Aspergillus fumigatus that complicates patients with asthma and cystic fibrosis. The mainstay of treatment for ABPA remains oral corticosteroids, though this does not completely prevent exacerbations and may not prevent the decline in lung function. OBJECTIVES: The purpose of this review was to determine the efficacy of azoles in the treatment of Allergic Broncho-pulmonary Aspergillosis. SEARCH STRATEGY: The Cochrane Airways Group Asthma register was searched using the terms: (allergic bronchopulmonary aspergillosis OR aspergillosis OR allergic pulmonary aspergillosis OR allergic fungal and disease OR allergic mycotic and disease) AND (azole OR triazole OR itraconazole OR ketoconazole). SELECTION CRITERIA: All controlled trials that assessed the effect of azole antifungal agents compared to placebo or other standard therapy for ABPA were reviewed. Patients with cystic fibrosis were not included. DATA COLLECTION AND ANALYSIS: All identified trials were independently reviewed by both reviewers & all data collected. Trial quality was scored by the Cochrane assessment of allocation concealment & the Jadad scale of methodological quality. MAIN RESULTS: Twelve trials were identified, but only three were prospective, randomised and controlled. One demonstrated a reduction in immunological markers of disease activity and symptom scores using ketoconazole 400 mg daily for 12 month. There was no significant improvement in lung function. The other two examined the use of itraconazole for 16 weeks. In one there was a reduction in sputum eosinophils by 35% compared to 19% with placebo (p<0.01). In the same trial, the number of exacerbations requiring oral corticosteroids was 0.4 per patient with itraconazole compared with 1.3 per patient with placebo (p<0.03). Meta analysis of data from both trials showed that itraconazole treated patients were more likely to have decline in serum IgE over 25% or more (Odds Ratio 3.3; 95% confidence intervals 1.3, 8.2). REVIEWER'S CONCLUSIONS: Itraconazole modifies the immunologic activation associated with ABPA and improves clinical outcome in ABPA at least over the period of 16 weeks.

CitationsScopus - 21
2000Gibson PG, Charpin D, 'Educating adolescents about asthma [1] (multiple letters)', Chest, 118 1514-1515 (2000)
CitationsScopus - 3
2000Gibson PG, 'Educating Adolescents About Asthma', Chest, 118 1514-1515 (2000) [C3]
CitationsWeb of Science - 1
2000Thorne R, Marshall J, Shafren D, Gibson PG, Hart I, Burns G, 'The Integrins a3B1 and a6B1 Physically and Functionally Associate with CD36 in Human Melanoma Cells', Journal of Biological Chemistry, 275 35264-35275 (2000) [C1]
CitationsScopus - 67Web of Science - 66
Co-authorsRick Thorne
2000Wood LG, Fitzgerald DA, Gibson PG, Cooper DM, Garg ML, 'Lipid Peroxidation as Determined by Plasma Isoprostanes Is Related to Disease Severity in Mild Asthma', Lipids, 35;9 967-974 (2000) [C1]
CitationsScopus - 114Web of Science - 100
Co-authorsManohar Garg, Lisa Wood
2000Gibson PG, 'Letter to the Editor', JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 106 1-2 (2000) [C3]
2000Gibson PG, 'Monitoring the patient with asthma: An evidence-based approach', Journal of Allergy and Clinical Immunology, 106 17-26 (2000) [C1]
CitationsScopus - 64Web of Science - 52
2000Gibson PG, Saltos N, Borgas T, 'Airway mast cells and eosinophils correlate with clinical severity and airway hyperresponsiveness in corticosteroid-treated asthma', Journal of Allergy and clinical Immunology, 105 752-759 (2000) [C1]
CitationsScopus - 79Web of Science - 67
2000Jones P, Gibson PG, Henry R, 'The prevalence of asthma appears to be inversely related to the incidence of typhoid and tuberculosis: hypothesis to explain the variation in asthma prevalence around the world', Medical Hypotheses, 55 40-42 (2000) [C1]
CitationsWeb of Science - 15
2000Gibson PG, Henry R, Thomas P, 'Noninvasive assessment of airway inflammation in children: induced sputum, exhaled nitric oxide, and breath condensate', European Respiratory Journal, 16 1008-1015 (2000) [C1]
CitationsScopus - 120Web of Science - 92
2000Wark PA, Saltos N, Simpson J, Slater S, Hensley MJ, Gibson PG, 'Induced sputum easinophils and neutrophils and bronchiectasis severity in allergic bronchopulmonary aspergillosis', European Respiratory Journal, 16 1095-1101 (2000) [C1]
CitationsScopus - 51Web of Science - 39
Co-authorsPeter Wark, Michael Hensley, Jodie Simpson
2000Gibson PG, Henry R, Shah S, Toneguzzi R, Francis J, Norzila M, Davies H, 'Validation of the ISAAC video questionnaire (AVQ3.0) in adolescents from a mixed ethnic background', Clinical and Experiemental Allergy, 30 1181-1187 (2000) [C1]
CitationsScopus - 48Web of Science - 32
2000Gibson PG, 'Commentary on "Glucocorticoids reduced short-term treatment failure in exacerbations of chronic obstructive pulmonary disease". Comment on: Niewoehner DE, Erbland ML, Deupree RH et al. Effect of systemic glucocorticoids on exacerbations of chronic obstruc', ACP JOURNAL CLUB, 132 14 (2000) [C3]
2000Gibson PG, Henry R, Coughlan J, 'Review: Treatment of gastroesophageal reflux does not improve asthma outcomes', ACP Journal Club, 132 15 (2000) [C3]
2000Norzila M, Fakes K, Henry R, Simpson J, Gibson PG, 'Interleukin-8 secretion and neutrophil recruitment accompanies induced sputum eosinophil activation in children with acute asthma', American Journal of respiratory and Critical Care Medicine, 161 769-774 (2000) [C1]
CitationsWeb of Science - 135
Co-authorsJodie Simpson
2000Wark PA, Gibson PG, Fakes K, 'Induced sputum eosinophils in the assessment of asthma and chronic cough*', Respirology, 5 51-57 (2000) [C1]
CitationsScopus - 17
Co-authorsPeter Wark
2000Gibson PG, 'European Respiratory Society Annual Congress', I Drugs, 3 56-58 (2000) [C3]
2000Wark PA, Wilson A, Gibson PG, 'Azoles for allergic bronchopulmonary aspergillosis', The Cochrane Library, 1-9 (2000) [C1]
Co-authorsPeter Wark
2000Gibson PG, Coughlan J, Wilson AJ, Abramson M, Bauman A, Hensley MJ, Walters EH, 'Self-management education and regular practitioner review for adults with asthma.', Cochrane database of systematic reviews (Online : Update Software), (2000)

BACKGROUND: A key component of many asthma management guidelines is the recommendation for patient education and regular medical review. A number of controlled trials have been conducted to measure the effectiveness of asthma education programmes. These programmes improve patient knowledge, but their impact on health outcomes is less well established. This review was conducted to examine the strength of evidence supporting Step 6 of the Australian Asthma Management Plan: "Educate and Review Regularly"; to test whether health outcomes are influenced by education and self-management programmes. OBJECTIVES: The objective of this review was to assess the effects of asthma self-management programmes, when coupled with regular health practitioner review, on health outcomes in adults with asthma. SEARCH STRATEGY: We searched the Cochrane Airways Group trials register and reference lists of articles. SELECTION CRITERIA: Randomised trials of self-management education in adults over 16 years of age with asthma. DATA COLLECTION AND ANALYSIS: Trial quality was assessed and data were extracted independently by two reviewers. Study authors were contacted for confirmation. MAIN RESULTS: Twenty-five trials were included. Self-management education was compared with usual care in 22 studies. Self-management education reduced hospitalisations (odds ratio 0.57, 95% confidence interval 0.38 to 0.88); emergency room visits (odds ratio 0.71, 95% confidence interval (0.57 to 0.90); unscheduled visits to the doctor (odds ratio 0.57, 95% confidence interval 0.40 to 0.82); days off work or school (odds ratio 0.55, 95% confidence interval 0.38 to 0. 79); and nocturnal asthma (odds ratio 0.53, 95% confidence interval 0.39 to 0.72). Measures of lung function were little changed. Self-management programmes that involved a written action plan showed a greater reduction in hospitalisation than those that did not (odds ratio 0.35, 95% confidence interval 0.18 to 0.68). People who managed their asthma by self-adjustment of their medications using an individualised written plan had better lung function than those whose medications were adjusted by a doctor. REVIEWER'S CONCLUSIONS: Training in asthma self-management which involves self-monitoring by either peak expiratory flow or symptoms, coupled with regular medical review and a written action plan appears to improve health outcomes for adults with asthma. Training programmes which enable people to adjust their medication using a written action plan appear to be more effective than other forms of asthma self-management.

CitationsScopus - 62
Co-authorsMichael Hensley, Amanda Wilson
2000Gibson PG, Henry RL, Coughlan JL, 'Gastro-oesophageal reflux treatment for asthma in adults and children.', Cochrane database of systematic reviews (Online : Update Software), (2000)

BACKGROUND: Asthma and gastro-oesophageal reflux are both common medical conditions and often co-exist. Studies have shown conflicting results concerning the effects of lower oesophageal acidification as a trigger of asthma. Furthermore, asthma might precipitate gastro-oesophageal reflux. Thus a temporal association between the two does not establish that gastro-oesophageal reflux triggers asthma. Randomised trials of a number of treatments for gastro-oesophageal reflux in asthma have been conducted, with conflicting results. OBJECTIVES: The objective of this review was to evaluate the effectiveness of treatments for gastro-oesophageal reflux in terms of their benefit on asthma. SEARCH STRATEGY: The Cochrane Airways Group trials register, review articles and reference lists of articles were searched. SELECTION CRITERIA: Randomised controlled trials of treatment for oesophageal reflux in adults and children with a diagnosis of both asthma and gastro-oesophageal reflux. DATA COLLECTION AND ANALYSIS: Trial quality and data extraction were carried out by two independent reviewers. Authors were contacted for confirmation or more data. MAIN RESULTS: Nine trials met the inclusion criteria. Interventions included proton pump inhibitors (n=3), histamine antagonists (n=5), surgery (n=1) and conservative management (n=1). Treatment duration ranged from 1 week to 6 months. A temporal association between asthma and gastro-oesophageal reflux was investigated in 4 trials and found to be present in a proportion of participants in these trials. Anti-reflux treatment did not consistently improve lung function, asthma symptoms, nocturnal asthma or the use of asthma medications. REVIEWER'S CONCLUSIONS: In asthmatic subjects with gastro-oesophageal reflux, (but who were not recruited specifically on the basis of reflux-associated respiratory symptoms), there was no overall improvement in asthma following treatment for gastro-oesophageal reflux. Subgroups of patients may gain benefit, but it appears difficult to predict responders.

2000Gibson PG, Coughlan J, Wilson AJ, Hensley MJ, Abramson M, Bauman A, Walters EH, 'Limited (information only) patient education programs for adults with asthma.', Cochrane database of systematic reviews (Online : Update Software), (2000)

BACKGROUND: A key component of many asthma management guidelines is the recommendation for patient education and regular medical review. A number of controlled trials have been conducted to measure the effectiveness of asthma education programmes. These programmes improve patient knowledge, but their impact on health outcomes is less well established. At its simplest level, education is limited to the transfer of information about asthma, its causes and its treatment. This review focused on the effects of limited asthma education. OBJECTIVES: The objective of this review was to assess the effects of limited (i.e. information only) asthma education on health outcomes in adults with asthma. SEARCH STRATEGY: We searched the Cochrane Airways Group trials register and reference lists of articles. SELECTION CRITERIA: Randomised and controlled trials of individual asthma education involving information transfer only in adults over 16 years of age. DATA COLLECTION AND ANALYSIS: Trial quality was assessed and data were extracted independently by two reviewers. Study authors were contacted for missing information. MAIN RESULTS: Eleven trials were included. They were of variable quality. Limited asthma education did not reduce hospitalisation for asthma (weighted mean difference -0.03 average hospitalisations per person per year, 95% confidence interval -0.09 to 0.03). There was no effect on doctor visits, lung function and medication use. The effects on asthma symptoms were variable. There was no reduction in days lost from normal activity, but perceived asthma symptoms did improve after limited asthma education (odds ratio 0.40, 95% confidence interval 0.18 to 0.86). In one study, limited asthma education was associated with reduced emergency department visits (weighted mean difference -2.76 average visits per person per year, 95% confidence interval -4.34 to 1.18). REVIEWER'S CONCLUSIONS: Use of limited asthma education as it has been practiced does not appear to improve health outcomes in adults with asthma. However the use of information in the emergency department may be effective, but this needs to be confirmed.

CitationsScopus - 28
Co-authorsMichael Hensley, Amanda Wilson
2000Gibson PG, Coughlan J, Wilson AJ, Hensley MJ, Abramson M, Bauman A, Walters EH, 'Limited (information only) patient education programs for adults with asthma.', Cochrane database of systematic reviews (Online), (2000)

BACKGROUND: A key component of many asthma management guidelines is the recommendation for patient education and regular medical review. A number of controlled trials have been conducted to measure the effectiveness of asthma education programmes. These programmes improve patient knowledge, but their impact on health outcomes is less well established. At its simplest level, education is limited to the transfer of information about asthma, its causes and its treatment. This review focused on the effects of limited asthma education. OBJECTIVES: The objective of this review was to assess the effects of limited (i.e. information only) asthma education on health outcomes in adults with asthma. SEARCH STRATEGY: We searched the Cochrane Airways Group trials register and reference lists of articles. SELECTION CRITERIA: Randomised and controlled trials of individual asthma education involving information transfer only in adults over 16 years of age. DATA COLLECTION AND ANALYSIS: Trial quality was assessed and data were extracted independently by two reviewers. Study authors were contacted for missing information. MAIN RESULTS: Eleven trials were included. They were of variable quality. Limited asthma education did not reduce hospitalisation for asthma (weighted mean difference -0.03 average hospitalisations per person per year, 95% confidence interval -0.09 to 0.03). There was no effect on doctor visits, lung function and medication use. The effects on asthma symptoms were variable. There was no reduction in days lost from normal activity, but perceived asthma symptoms did improve after limited asthma education (odds ratio 0.40, 95% confidence interval 0.18 to 0.86). In one study, limited asthma education was associated with reduced emergency department visits (weighted mean difference -2.76 average visits per person per year, 95% confidence interval -4.34 to 1.18). REVIEWER'S CONCLUSIONS: Use of limited asthma education as it has been practiced does not appear to improve health outcomes in adults with asthma. However the use of information in the emergency department may be effective, but this needs to be confirmed.

Co-authorsMichael Hensley
2000Gibson PG, Coughlan J, Wilson AJ, Abramson M, Bauman A, Hensley MJ, Walters EH, 'Self-management education and regular practitioner review for adults with asthma.', Cochrane database of systematic reviews (Online), (2000)

BACKGROUND: A key component of many asthma management guidelines is the recommendation for patient education and regular medical review. A number of controlled trials have been conducted to measure the effectiveness of asthma education programmes. These programmes improve patient knowledge, but their impact on health outcomes is less well established. This review was conducted to examine the strength of evidence supporting Step 6 of the Australian Asthma Management Plan: "Educate and Review Regularly"; to test whether health outcomes are influenced by education and self-management programmes. OBJECTIVES: The objective of this review was to assess the effects of asthma self-management programmes, when coupled with regular health practitioner review, on health outcomes in adults with asthma. SEARCH STRATEGY: We searched the Cochrane Airways Group trials register and reference lists of articles. SELECTION CRITERIA: Randomised trials of self-management education in adults over 16 years of age with asthma. DATA COLLECTION AND ANALYSIS: Trial quality was assessed and data were extracted independently by two reviewers. Study authors were contacted for confirmation. MAIN RESULTS: Twenty-five trials were included. Self-management education was compared with usual care in 22 studies. Self-management education reduced hospitalisations (odds ratio 0.57, 95% confidence interval 0.38 to 0.88); emergency room visits (odds ratio 0.71, 95% confidence interval (0.57 to 0.90); unscheduled visits to the doctor (odds ratio 0.57, 95% confidence interval 0.40 to 0.82); days off work or school (odds ratio 0.55, 95% confidence interval 0.38 to 0. 79); and nocturnal asthma (odds ratio 0.53, 95% confidence interval 0.39 to 0.72). Measures of lung function were little changed. Self-management programmes that involved a written action plan showed a greater reduction in hospitalisation than those that did not (odds ratio 0.35, 95% confidence interval 0.18 to 0.68). People who managed their asthma by self-adjustment of their medications using an individualised written plan had better lung function than those whose medications were adjusted by a doctor. REVIEWER'S CONCLUSIONS: Training in asthma self-management which involves self-monitoring by either peak expiratory flow or symptoms, coupled with regular medical review and a written action plan appears to improve health outcomes for adults with asthma. Training programmes which enable people to adjust their medication using a written action plan appear to be more effective than other forms of asthma self-management.

Co-authorsMichael Hensley
2000Gibson PG, Henry RL, Coughlan JL, 'Gastro-oesophageal reflux treatment for asthma in adults and children.', Cochrane database of systematic reviews (Online), (2000)

BACKGROUND: Asthma and gastro-oesophageal reflux are both common medical conditions and often co-exist. Studies have shown conflicting results concerning the effects of lower oesophageal acidification as a trigger of asthma. Furthermore, asthma might precipitate gastro-oesophageal reflux. Thus a temporal association between the two does not establish that gastro-oesophageal reflux triggers asthma. Randomised trials of a number of treatments for gastro-oesophageal reflux in asthma have been conducted, with conflicting results. OBJECTIVES: The objective of this review was to evaluate the effectiveness of treatments for gastro-oesophageal reflux in terms of their benefit on asthma. SEARCH STRATEGY: The Cochrane Airways Group trials register, review articles and reference lists of articles were searched. SELECTION CRITERIA: Randomised controlled trials of treatment for oesophageal reflux in adults and children with a diagnosis of both asthma and gastro-oesophageal reflux. DATA COLLECTION AND ANALYSIS: Trial quality and data extraction were carried out by two independent reviewers. Authors were contacted for confirmation or more data. MAIN RESULTS: Nine trials met the inclusion criteria. Interventions included proton pump inhibitors (n=3), histamine antagonists (n=5), surgery (n=1) and conservative management (n=1). Treatment duration ranged from 1 week to 6 months. A temporal association between asthma and gastro-oesophageal reflux was investigated in 4 trials and found to be present in a proportion of participants in these trials. Anti-reflux treatment did not consistently improve lung function, asthma symptoms, nocturnal asthma or the use of asthma medications. REVIEWER'S CONCLUSIONS: In asthmatic subjects with gastro-oesophageal reflux, (but who were not recruited specifically on the basis of reflux-associated respiratory symptoms), there was no overall improvement in asthma following treatment for gastro-oesophageal reflux. Subgroups of patients may gain benefit, but it appears difficult to predict responders.

2000Wilson AJ, Gibson PG, Coughlan J, 'Long acting beta-agonists versus theophylline for maintenance treatment of asthma.', Cochrane database of systematic reviews (Online), (2000)

BACKGROUND: Theophylline and long acting beta2-agonists are bronchodilators used for the management of persistent asthma symptoms, especially nocturnal asthma. They represent different classes of drug with differing side-effect profiles. OBJECTIVES: To assess the comparative efficacy, safety and side-effects of long-acting beta-agonists and theophylline in the maintenance treatment of asthma. SEARCH STRATEGY: Randomised, controlled trials (RCTs) were identified using the Cochrane Airways Group register. The register was searched using the following terms: asthma and theophylline and long acting beta-agonist or formoterol or foradile or eformoterol or salmeterol or bambuterol or bitolterol. Titles and abstracts were then screened to identify potentially relevant studies. The bibliography of each RCT was searched for additional RCTs. Authors of identified RCTs were contacted for other relevant published and unpublished studies. SELECTION CRITERIA: All included studies were RCTs involving adults and children with clinical evidence of asthma. These studies must have compared oral sustained release and/or dose adjusted theophylline with an inhaled long-acting beta-agonist. DATA COLLECTION AND ANALYSIS: Potentially relevant trials, identified by screening titles and/or abstracts, were obtained. Two reviewers independently assessed full text versions of these trials to decided whether the trial should be included in the review, and assessed its methodological quality. Where there was disagreement between reviewers, this was resolved by consensus, or reference to a third party. Data were extracted by two independent reviewers. Inter-rater reliability was assessed by simple agreement. Study authors were contacted to clarify randomisation methods, provide missing data, verify the data extracted and identify unpublished studies. Relevant pharmaceutical manufacturers were also contacted. MAIN RESULTS: Six trials met the inclusion criteria. Five used salmeterol and one, biltoterol. They were of varying quality. There was a trend for salmeterol to improve FEV1 more than theophylline in three studies and salmeterol use was associated with more symptom free nights. Bitolterol, used in only one study, was reported to be less effective than theophylline. Subjects taking salmeterol experienced fewer adverse events than those using theophylline (Relative Risk 0.38; 95%Confidence Intervals 0.25, 0.57). Significant reductions were reported for central nervous system adverse events (Relative Risk 0.51; 95%Confidence Intervals 0.30, 0.88) and gastrointestinal adverse events (Relative Risk 0.32; 95%Confidence Intervals 0.17, 0.59). REVIEWER'S CONCLUSIONS: Salmeterol may be more effective than theophylline in reducing asthma symptoms including night waking and improving lung function. More adverse events occurred in subjects using theophylline when compared to salmeterol.

CitationsScopus - 14
Co-authorsAmanda Wilson
2000Wark P, Wilson AW, Gibson PG, 'Azoles for allergic bronchopulmonary aspergillosis.', Cochrane database of systematic reviews (Online), (2000)

BACKGROUND: Allergic Broncho-pulmonary Aspergillosis (ABPA) is hypersensitivity to the fungus Aspergillus Fumigatus that complicates patients with asthma and cystic fibrosis. The condition usually results in an increase in symptoms, a greater reliance on corticosteroids to control the disease process and may lead to a progressive decline in lung function. The mainstay of treatment for ABPA remains oral corticosteroids, though this does not completely prevent exacerbations and may not prevent the decline in lung function. OBJECTIVES: The purpose of this review is to determine the efficacy of azoles in the treatment of ABPA SEARCH STRATEGY: An initial search was carried out using the Cochrane Airways Group Asthma RCT register. The register was searched using the following terms: (asthma or wheeze) and (allergic bronchopulmonary aspergillosis or aspergillosis or allergic pulmonary aspergillosis or allergic fungal and disease or allergic mycotic and disease) and (azole or triazole or itraconazole or ketoconazole). SELECTION CRITERIA: All controlled trials that assessed the effect of azole antifungal agents compared to placebo or other standard, for any duration or dose regimen in subjects with ABPA of any age or severity were reviewed. Studies in languages other than English were included. DATA COLLECTION AND ANALYSIS: All identified trials were independently reviewed by both reviewers & all data collected. Trial quality was scored by the Cochrane assessment of allocation concealment & the Jadad scale of methodological quality. MAIN RESULTS: A total of 11 trials were identified concerning the use of azoles in ABPA. Only two prospective controlled trials were identified. The first trial examined the use of Ketoconazole 400 mg daily for 12 months and demonstrated a reduction in immunological markers of disease activity and symptom scores, there was no significant improvement in lung function. The other trial examined the use of itraconazole for 16 weeks. This demonstrated a reduction in corticosteroid usage, an improvement in immunological markers, an improvement in pulmonary function and exercise tolerance. This study was only available as an abstract and limited details were available. REVIEWER'S CONCLUSIONS: There is insufficient information available to recommend the use of azole anti-fungal agents in the routine treatment of patients with ABPA.

1999Gibson PG, 'Asthma in general practice: action plans or planned actions', MEDICAL JOURNAL OF AUSTRALIA, 171 67-67 (1999)
Author URL
CitationsScopus - 5Web of Science - 3
1999Gibson PG, 'Airway hyperresponsiveness in asthma', THORAX, 54 656-657 (1999)
Author URL
CitationsWeb of Science - 2
1999Gibson PG, Brusasco V, Crimi E, Pellegrino R, 'Airway hyperresponsiveness in asthma (multiple letters) [4]', Thorax, 54 656-657 (1999)
CitationsScopus - 2
1999Gibson PG, Wilson AJ, Wlodarczyk JH, Fakes K, Hensley MJ, 'Different patterns of airway inflammation during asthma exacerbation: a controlled dose reduction study.', JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 103 S61-S61 (1999)
Author URL
Co-authorsAmanda Wilson, Michael Hensley
1999Gibson PG, Coughlan J, Abramson M, 'Self-management education for adults with asthma improves health outcomes', WESTERN JOURNAL OF MEDICINE, 170 266-266 (1999)
Author URL
CitationsScopus - 12Web of Science - 5
1999Fitzgerald DA, Wood LG, Cooper DM, Gibson PG, Garg ML, 'Isoprostanes and antioxidant defences in cystic fibrosis', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 159 A682-A682 (1999)
Author URL
Co-authorsLisa Wood, Manohar Garg
1999Wark P, Simpson J, Fakes K, Burgess H, Timmins N, Hensley M, Gibson PG, 'Airway inflammation in allergic bronchopulmonary aspergillosis', Respirology, 4 (1999)

Allergic bronchopulmonary aspergillosis (ABPA) is a serious complication of asthma. In uncomplicated asthma airway inflammation(ai) is characterised by sputum eosinophilia without an increase in the total cell count (TCC). In bronchiectasis the intensity of ai increased and there is a neutrophil infiltrate. Airway inflammation in ABPA is not well defined. This study tested the hypothesis that ai in ABPA would be of increased intensity with a mixed eosinophil/neutrophil pattern. Methods: In subjects with asthma, ABPA was assessed by 5 criteria; 1. positive allergy skin test to Aspergillus Fumigatus (Af); 2. raised specific serum IgE to Af; 3. positive precipitating antibodies to Af; 4. total IgE > 10001U/ml and 5. bronchiectasis (CT scan). Subjects were classified as definite ABPA (n=13) with criteria 1, 2, 3 and either 4 or 5; or as probable ABPA (n=18) with 1 and 2 and either 3, 4 or 5 (n=13). These groups were combined for analysis. Af sensitised subjects (n=19 with positive skin testing alone), were compared to a matched group with asthma (negative to Af on skin test) (n=15) and healthy controls (n=8). Spirometry, saline challenge and sputum induction were performed, with results reported as medians and interquartile ranges. Results: Patients with ABPA had an increased TCC (4.6, 0.9-29.6) compared to: Af sensitised (3.6, 1.4-7.4), asthma (1.5, 0.8-3.2), and controls (1.35, 1.3-1.4) (p<0.05). Those with ABPA had increased sputum eosinophils (3.8, 0.3-16.3), compared to: Af sensitised (1.4, 0.1-6), asthma (1.6, 0.01-3), and controls (0.3, 0.3-0.31 ) (p=0.001). Those with ABPA had increased levels of eosinophil cationic protein(ng/ml) (5471, 311-42485) compared to: Af sensitised (1432, 338-6902), asthma (244, 78-857), and controls (110, 99-121 ) (p<0.001). Neutrophil counts were similar in all groups. Myeloperoxidase was similar in ABPA (232, 66-454) and asthma (177, 57-318) (p=0.3) but greater than in healthy controls (76, 76-89) Conclusion: Airway inflammation in ABPA is of increased intensity compared to that of chronic asthma. Unlike bronchiectasis, the cellular infiltrate is predominantly eosinophilic. The eosinophils demonstrate increased activation.

1999Simpson J, Wilson A, Fakes K, Burgess H, Saltos N, Gibson PG, 'Neutrophil activation in symptomatic asthma without eosinophilia', Respirology, 4 (1999)

In mild asthma there is typically an infiltrate with eosinophils, which improves with corticosteroid therapy. Asthma can persist despite high dose inhaled corticosteroid therapy (ICS). Aim: The aim of this study was to establish the characteristics of airway inflammation in asthma, which persists despite high dose inhaled corticosteroids. Method: Adults (n=73) with asthma and persistent symptoms who were taking =1000g ICS underwent hypertonic saline challenge and sputum induction. Sputum was dispersed using dithiothreitol and assayed for total cell count, cellular differential, supernatant eosinophil cationic protein (ECP ng/mL), myeloperoxidase (MPO ng/mL) and interleukin-8 (IL-8 ng/mL). Subjects were categorised into 4 groups based upon the presence or absence of airway hyperresponsiveness (AHR) and increased sputum eosinophils (E; being >5%). Results: Subjects with eosinophilic AHR (EAR n=16) had 22% E, compared to those with noneosinophilic AHR (NEAR, n=40) who had 1.5% E. Those with asthma in remission (normal AHR and E; n=14) had 1.2% E. Neutrophil % was similar in all 3 groups (p>0.05). ECP was highest in the EAR positive group (7572) compared with NEAR (2834) and remission (504; p = 0.001). MPO was elevated in NEAR (275) and EAR (253) compared with remission (189; p = 0.05). IL-8 levels were highest in NEAR (86.2) compared to EAR (36.5) and remission (12.9; p = 0.03). Conclusion: Asthma which remains symptomatic despite high dose ICS consists of 2 different inflammatory patterns. While some have typical eosinophil inflammation, the most common pattern is cellular (neutrophil and eosinophil) activation, with suppressed eosinophil counts. This may be mediated by IL-8 secretion. There is heterogeneity of airway inflammation in symptomatic asthma.

1999Gibson PG, Coughlan J, Abramson M, 'Review: Self-management education for adults with asthma improves health outcomes: Commentary', Evidence-Based Medicine, 4 15-15 (1999)
1999Gibson PG, Norzila MZ, Fakes K, Simpson J, Henry RL, 'Pattern of airway inflammation and its determinants in children with acute severe asthma', PEDIATRIC PULMONOLOGY, 28 261-270 (1999)
DOI10.1002/(SICI)1099-0496(199910)28:4<261::AID-PPUL5>3.0.CO;2-IAuthor URL
CitationsScopus - 61Web of Science - 45
Co-authorsJodie Simpson
1998Cai Y, Carty K, Henry RL, Gibson PG, 'Persistence of sputum eosinophilia in children with controlled asthma when compared with healthy children', EUROPEAN RESPIRATORY JOURNAL, 11 848-853 (1998)
DOI10.1183/09031936.98.11040848Author URL
CitationsScopus - 100Web of Science - 82
1998Gibson PG, Woolley KL, Carty K, Murree-Allen K, Saltos N, 'Induced sputum eosinophil cationic protein (ECP) measurement in asthma and chronic obstructive airway disease (COAD)', CLINICAL AND EXPERIMENTAL ALLERGY, 28 1081-1088 (1998)
Author URL
CitationsScopus - 38Web of Science - 38
1998Gibson PG, Shah S, Mamoon HA, 'Peer-led asthma education for adolescents: Impact evaluation', JOURNAL OF ADOLESCENT HEALTH, 22 66-72 (1998)
DOI10.1016/S1054-139X(97)00203-6Author URL
CitationsScopus - 43Web of Science - 38
1998Gibson PG, 'How to measure airway inflammation: Induced sputum', Canadian Respiratory Journal, 5 (1998)

Induced sputum examination has emerged as an important investigative tool in airway diseases. Sputum can be easily induced by ultrasonic nebulization of Hypertonic saline. Inprovements in sputum processing have established that sputum provides reproducible measurements of cell counts and fluid phase mediators. Adults and children with stable asthma demonstrate an infiltrate of eosinophils. With an exacerbation of asthma the eosinophil infiltrate increases and the cells become activated in response to cytokines including interleukin-5. A neutrophil infiltrate may accompany some exacerbations. Exacerbations resolve under the influence of corticosteroid therapy. Eosinophils undergo apoptosis and are removed by macrophages. Eosinophilic bronchitis is an important component in up to 20% of patients with chronic cough. Sputum examination promises to be an important technique to facilitate the understanding and management of asthma and cough in adults and children.

CitationsScopus - 6
1998Gibson PG, 'Severe exacerbation of chronic obstructive airways disease: Health resource use in general practice and hospital', Journal of Quality in Clinical Practice, 18 125-133 (1998)

The objective of this study is to examine the treatment of exacerbations of chronic obstructive airways disease (COAD) in the hospital and in the community setting using a retrospective study of patients admitted to a major teaching hospital combined with a general practice chart audit. The admission records for 248 admissions from 128 patients were reviewed. Most patients (70%) had visited their GP within 2 weeks of admission, antibiotics were prescribed for 30% of the exacerbations while 51% were treated with ingested corticosteroids. During hospitalization, features of infection were present in 64% (n = 159) of exacerbations and 79% (n = 196) received antibiotics. Patients were also treated with nebulized bronchodilators, oxygen and corticosteroids (82%). The median length of stay was 10 days (range 0-55). There was a high readmission rate (70%) at 1 year for exacerbation of COAD during the study period. Exacerbations of COAD frequently demonstrated the clinical features of infection. Treatment in general practice was less intensive than in hospital, and there is a need to reconcile these differences with studies of early therapy with antibiotics and corticosteroids. Although corticosteroids were used less often in general practice, the literature in this area is not conclusive and the evidence supporting guideline recommendations is not explicit. There are opportunities to examine the role of early therapy and early discharge programmes to minimize the cost burden from exacerbations of COAD.

CitationsScopus - 42
1998Gibson PG, Coughlan J, Wilson AJ, Shekelle PG, 'Review: Limited asthma education reduces emergency department visits but does not improve patient outcomes', Evidence-Based Medicine, 3 121-121 (1998)
1998Gibson PG, 'Loss-of-life cost for paediatric illness associated with parental smoking was estimated at U.S. $8.2 billion per year', Evidence-Based Medicine, 3 64-64 (1998)

Objective Tb calculate the costs of tobacco-related paediatric illness attributable to parental smoking in the United States. Design Cost-estimate study using techniques of literature synthesis to generate the incidence and costs of tobacco-related paediatric illness. Data sources and selection English-language articles were identified by searching MEDLINE, HEALTH, BIOETHICSLINE, ECONLIT, and Social Sciences Citation Index from January 1980 to May 1996. Articles that included children in the age range of neonate to 18 years were used. For cost data, only articles referring to the United States were included. National databases and textbooks were used to obtain estimates of the prevalence of parental smoking and the incidence of the diseases in question. Main outcome and cost measures Best estimates of the relative risk for smoking-related diseases in children exposed to parental smoking were obtained, and the attributable risk fraction (the fraction of cases of disease that would not have occurred if no one in the population had been exposed) and direct medical expenditures were calculated. The cost of illness (based on costs for loss of life) was also calculated. Costs were adjusted to 1993 U.S. dollars. Main results Estimated annual excess cases of childhood illness and death caused by parental smoking in the United States were 5 400 000 and 6200, respectively, leading to direct medical costs of $4.6 billion and loss-of-life costs of $8.2 billion (Table). Conclusion Loss-of-life cost for paediatric illness associated with parental smoking was estimated at U.S. $8.2 billion per year.

1998Henry RL, Gibson PG, Carty K, Cai Y, Francis JL, 'Airway inflammation after treatment with aerosolized deoxyribonuclease in cystic fibrosis', PEDIATRIC PULMONOLOGY, 26 97-100 (1998)
DOI10.1002/(SICI)1099-0496(199808)26:2<97::AID-PPUL4>3.0.CO;2-EAuthor URL
CitationsScopus - 18Web of Science - 13
1998Gibson PG, Wlodarczyk J, Hensley MJ, Henry RL, Cripps AW, Clancy RL, Gleeson M, 'Epidemiological association of airway inflammation with asthma symptoms and airway hyperresponsiveness in childhood', American Journal of Respiratory and Critical Care Medicine., 158 36-41 (1998) [C1]
CitationsScopus - 138Web of Science - 128
Co-authorsMaree Gleeson, Michael Hensley
1998Gibson PG, Zlatic K, Scott JL, Sewell W, Woolley K, Saltos N, 'Chronic cough resembles asthma with IL-5 and granulocyte-macrophage colony-stimulating factor gene expression in bronchoalveolar cells', Journal of Allergy and Clinical Immunology, 101 320-326 (1998) [C1]
CitationsScopus - 78Web of Science - 70
1998Hensley MJ, Gibson PG, 'Promoting evidence-based alternative medicine', Medical Journal of Australia, 169 573-574 (1998) [C1]
CitationsScopus - 15Web of Science - 13
Co-authorsMichael Hensley
1998Jones PD, Henry R, Gibson PG, Hankin RG, Carty K, 'Chemotherapy for malignancy induces a remission in asthma symptoms and airway inflammation but not airway hyperreponsivesness', Pediatric Pulmonology, 26 74-77 (1998) [C1]
CitationsScopus - 5Web of Science - 4
1997Carney IK, Gibson PG, MurreeAllen K, Saltos N, Olson LG, Hensley MJ, 'A systematic evaluation of mechanisms in chronic cough', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 156 211-216 (1997)
Author URL
CitationsScopus - 97Web of Science - 84
Co-authorsMichael Hensley
1997Thorne RF, Meldrum CJ, Harris SJ, Dorahy DJ, Shafren DR, Berndt MC, et al., 'CD36 forms covalently associated dimers and multimers in platelets and transfected COS-7 cells', BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 240 812-818 (1997)
DOI10.1006/bbrc.1997.7755Author URL
CitationsScopus - 25Web of Science - 24
Co-authorsRick Thorne
1996Gibson PG, 'Corticosteroids - Clinical applications: Exacerbations of asthma in adults', Australian Prescriber, 19 44-47 (1996)

Corticosteroids are essential to reverse the eosinophilic airway inflammation which causes symptomatic exacerbations of asthma. Much of the current variation in clinical practice is not justified by data from clinical trials. Oral prednisolone is as effective as intravenous therapy and very high doses of corticosteroid are no better than modest doses (30- 50 mg prednisolone). Corticosteroids should be given twice a day for optimum effect. Therapy does not need to be tapered, but can be ceased abruptly after 10 days in most patients who are also taking high-dose inhaled corticosteroids. There is an increasing role for inhaled corticosteroids in the management of mild exacerbations of asthma. The dose, route and duration of therapy need to be defined for each patient and written down as part of an action plan to enable early intervention in future exacerbations.

CitationsScopus - 7
1996Twaddell SH, Gibson PG, Carty K, Woolley KL, Henry RL, 'Assessment of airway inflammation in children with acute asthma using induced sputum', EUROPEAN RESPIRATORY JOURNAL, 9 2104-2108 (1996)
DOI10.1183/09031936.96.09102104Author URL
CitationsScopus - 75Web of Science - 61
1996Gibson PG, Stuart JE, Wlodarczyk J, Olson LG, Hensley MJ, 'Nasal inflammation and chronic ear disease in Australian Aboriginal children', JOURNAL OF PAEDIATRICS AND CHILD HEALTH, 32 143-147 (1996)
DOI10.1111/j.1440-1754.1996.tb00911.xAuthor URL
CitationsScopus - 16Web of Science - 15
Co-authorsMichael Hensley, John Stuart
1996Twaddell SH, Henry RL, Francis JL, Gibson PG, 'The prediction of hospital admission in children with acute asthma', JOURNAL OF PAEDIATRICS AND CHILD HEALTH, 32 532-535 (1996)
DOI10.1111/j.1440-1754.1996.tb00968.xAuthor URL
CitationsScopus - 14Web of Science - 12
1996Gleeson M, Clancy RL, Hensley MJ, Cripps AW, Henry RL, Wlodarczyk JH, Gibson PG, 'Development of bronchial hyperreactivity following transient absence of salivary IgA', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 153 1785-1789 (1996)
Author URL
CitationsScopus - 17Web of Science - 13
Co-authorsMichael Hensley
1996Woolley KL, Gibson PG, Carty K, Wilson AJ, Woolley MJ, 'Eosinophil apoptosis and the resolution of airway inflammation in asthma', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 154 237-243 (1996)
Author URL
CitationsScopus - 215Web of Science - 190
Co-authorsAmanda Wilson
1996Gibson PG, 'The use of continuous quality improvement methods to implement practice guidelines in asthma', Journal of Quality in Clinical Practice, 16 87-102 (1996)

National asthma management guidelines have improved awareness of the rising morbidity and mortality from asthma but have not been widely implemented at a local level. This paper describes the use of continuous quality improvement techniques to facilitate the implementation of asthma management guidelines within a tertiary hospital setting. A baseline audit demonstrated satisfactory emergency assessment and treatment, but identified poor compliance with the patient education aspects of the asthma management plan. An evaluation of the literature demonstrated that programs combining asthma education and management were effective when directed towards adults with a recent severe asthma exacerbation. An asthma education and management service was developed to address these deficits. A repeat audit was conducted which identified improvements in asthma control and management skills for patients attending the education program, together with reductions in asthma re-admission rates for patients referred to the service. Ongoing quality assessments will target nonattenders to the service and the maintenance of asthma skills. An area Asthma Health Outcomes Council was formed to address the issues of asthma management throughout the area health service.

CitationsScopus - 27
Co-authorsAmanda Wilson
1995Gibson PG, Nair BR, Davies C, Saunders NA, 'Development and implementation of an innovative intern training programme', Medical Education, 29 220-224 (1995)

The quality of medical education during internship is a cause for concern. This paper describes a structured educational programme for interns that was based around learning modules, clinical attachments and bedside teaching. The programme was incorporated into the term rotation of interns within an Area Health Service, and evaluated. Learning modules were timetabled by a Programme Coordinator and interns were reminded to attend. Clinical attachments were organized by the interns from a list of willing supervisors. Attendance at timetabled learning modules averaged 67%, which was greater than the 27% attendance at clinical attachments. Both sessions received high ratings for quality and clinical relevance. This structured education programme was based upon adult learning methods and was both feasible and well received by interns. Intern training programmes need to be programmed into the working week to ensure attendance, and modified following evaluation by interns. Such programmes should be considered by all hospitals to which interns are allocated.

CitationsScopus - 4
1995Gibson PG, Mattoli S, Sears MR, Dolovigh J, Hargreave FE, 'Increased peak flow variability in children with asymptomatic hyperresponsiveness', European Respiratory Journal, 8 1731-1735 (1995)

The relevance of increased methacholine airway responsiveness detected in children with no current or past symptoms of asthma is not known. We wished for determine whether the presence of airway hyperresponsiveness in asymptomatic children is also associated with abnormal variability of peak expiratory flow (PEF). In 12 asymptomatic children with methacholine hyperresponsiveness, we examined the diurnal variation of peak expiratory flow (PEF) and response to inhaled bronchodilator. Twelve asthmatic children with a comparable range of methacholine hyperresponsiveness, and 12 normal children without methacholine responsiveness, were used as positive and negative controls. The children were aged 11 (range 9-14) yrs. The mean diurnal variation of PEF in those children with asymptomatic hyperresponsiveness was increased at 9.3%, to a degree comparable to the symptomatic asthmatic children (10.7%), and greater than the normal children (5.7%). Methacholine stimulated airway constriction was associated with symptoms in subjects from each group, indicating that the children were capable of perceiving airway constriction. We conclude that asymptomatic children with methacholine airway hyperresponsiveness have other evidence of mild variable airflow obstruction with increased diurnal PEF variability, and can perceive airflow limitation. The lack of symptoms in the children with airway hyperresponsiveness could be due to an insufficient stimulus to cause symptomatic obstruction, or the absence of eosinophilic airway inflammation, which may be a requirement for the development of symptomatic airway hyperresponsiveness.

DOI10.1183/09031936.95.08101731
CitationsScopus - 29
1995Gibson PG, Hargreave FE, Girgis-Gabardo A, Morris M, Denburg JA, Dolovich J, 'Chronic cough with eosinophilic bronchitis: Examination for variable airflow obstruction and response to corticosteroid', Clinical and Experimental Allergy, 25 127-132 (1995)

The purpose of this study was to examine airway responsiveness, sputum cells and the effects of inhaled corticosteroid in the chronic cough syndrome associated with eosinophilic bronchitis. We studied nine consecutive referrals with chronic cough, sputum with >10% eosinophils, normal spirometry, and normal methacholine airway responsiveness. Clinical assessment, sputum analysis, allergy skin tests and a methacholine inhalation test were performed at the first visit. Peak expiratory flow (PEF) was measured twice daily for 1 week followed by an adenosine monophosphate (AMP) inhalation test. Subjects were then treated with inhaled beclomethasone 0.4 mg twice daily for 7 days. Sputum analysis and measurement of methacholine responsiveness were then repeated. Excessive airway narrowing to methacholine was not present in any of the subjects. A methacholine plateau response was present in five subjects. Hyperresponsiveness to AMP was absent in six of the nine subjects, and PEF variability was not increased for eight subjects. Corticosteroid therapy led to a reduction in sputum eosinophil counts from 40.1 (SD 21 4)% to 4.0 (4.5)% but there was no significant change in metachromatic cell counts (0.8 SD 0.5% vs 0.6 SD 0.6%) or total cell counts. Methacholine responsiveness improved within the normal range in the three subjects in whom it could be determined. Chronic cough associated with eosinophilic airway inflammation can occur in the absence of variable airflow obstruction (asthma) and can improve after treatment with inhaled corticosteroid. This treatment can reduce the level of methacholine responsiveness within the normal range and reduces sputum eosinophils but not mast eels. These results suggest that the occurrence of variable airflow obstruction depends on the baseline level of methacholine responsiveness, the degree of eosinophilic infiltration and the degree to which methacholine responsiveness becomes heightened.

DOI10.1111/j.1365-2222.1995.tb01017.x
CitationsScopus - 126
1995GIBSON PG, WLODARCZYK J, HENSLEY MJ, MURREEALLEN K, OLSON LG, SALTOS N, 'USING QUALITY-CONTROL ANALYSIS OF PEAK EXPIRATORY FLOW RECORDINGS TO GUIDE THERAPY FOR ASTHMA', ANNALS OF INTERNAL MEDICINE, 123 488-& (1995)
Author URL
CitationsScopus - 56Web of Science - 59
Co-authorsMichael Hensley
1995GIBSON PG, HENRY RL, VIMPANI GV, HALLIDAY J, 'ASTHMA KNOWLEDGE, ATTITUDES, AND QUALITY-OF-LIFE IN ADOLESCENTS', ARCHIVES OF DISEASE IN CHILDHOOD, 73 321-326 (1995)
Author URL
CitationsScopus - 103Web of Science - 80
1995GIBSON PG, WLODARCZYK JH, BORGAS T, 'DRUG-DELIVERY IN ASTHMA - A COMPARISON OF SPACERS WITH A JET NEBULIZER', AUSTRALIAN AND NEW ZEALAND JOURNAL OF MEDICINE, 25 324-329 (1995)
DOI10.1111/j.1445-5994.1995.tb01897.xAuthor URL
CitationsScopus - 11Web of Science - 10
1995GIBSON PG, TALBOT PI, TONEGUZZI RC, 'SELF-MANAGEMENT, AUTONOMY, AND QUALITY-OF-LIFE IN ASTHMA', CHEST, 107 1003-1008 (1995)
DOI10.1378/chest.107.4.1003Author URL
CitationsScopus - 89Web of Science - 66
1995Gibson PG, Talbot PI, Toneguzzi RC, 'Self-management, autonomy, and quality of life in asthma. Population Medicine Group 91C.', Chest, 107 1003-1008 (1995)
DOI10.1378/chest.107.4.1003
1994Gibson PG, 'Computer-supported education reduced hospital admissions in asthma', Annals of Internal Medicine, 121 20-21 (1994)
1994SHAH S, GIBSON PG, WACHINGER S, 'RECOGNITION AND CRISIS MANAGEMENT OF ASTHMA IN SCHOOLS', JOURNAL OF PAEDIATRICS AND CHILD HEALTH, 30 312-315 (1994)
DOI10.1111/j.1440-1754.1994.tb00652.xAuthor URL
CitationsWeb of Science - 12
1994HENRY RL, GIBSON PG, VIMPANI GV, HAZELL J, LEGGATT R, MOWBRAY C, et al., 'INTEGRATED HEALTH AND EDUCATION INPUT IN THE DEVELOPMENT OF EDUCATIONAL RESOURCES ABOUT ASTHMA FOR SCHOOLS', JOURNAL OF PAEDIATRICS AND CHILD HEALTH, 30 492-496 (1994)
DOI10.1111/j.1440-1754.1994.tb00719.xAuthor URL
CitationsScopus - 8Web of Science - 8
1993GIBSON PG, MURREEALLEN K, HOPKINS Y, BENNETTS K, 'DO FOOD-ADDITIVES INDUCE AIRWAYS INFLAMMATION IN ASTHMA', AMERICAN REVIEW OF RESPIRATORY DISEASE, 147 A559-A559 (1993)
Author URL
1993GIBSON PG, HENSLEY MJ, HOPKINS YJ, WLODARCZYK J, TONEGUZZI R, 'EPIDEMIC ASTHMA AFTER A THUNDERSTORM - CLINICAL AND CYTOLOGICAL FEATURES OF NEW ONSET ASTHMA', AMERICAN REVIEW OF RESPIRATORY DISEASE, 147 A560-A560 (1993)
Author URL
Co-authorsMichael Hensley
1993Gibson PG, Allen CJ, Yang JP, Wong BJO, Dolovich J, Denburg J, Hargreave FE, 'Intraepithelial mast cells in allergic and nonallergic asthma: Assessment using bronchial brushings', American Review of Respiratory Disease, 148 80-86 (1993)

Mast cell mediators are known to contribute to the pathogenesis of asthma. There is some disagreement concerning the numbers of mast cells in asthmatic mucosa. In this study a standardized bronchial brush technique was developed and used to assess intraepithelial mast cells and other inflammatory cells in allergic and nonallergic asthmatic and nonasthmatic subjects. A total of 10 nonasthmatic (5 allergic) and 13 asthmatic (8 allergic) subjects with stable controlled asthma treated with ß-agonist only were assessed by history, spirometry, allergy prick tests, and methacholine airway responsiveness. During fiberoptic bronchoscopy, bronchoalveolar lavage (BAL) was performed from the middle lobe and standardized bronchial brushings were taken from the lingula and left lower lobe bronchi. Quantitative cell counts were performed blind to the clinical characteristics of the subjects. The average total cell recovery from the brushings was 1.04 (SEM 0.09) x 106 ml, with a cell viability of 64% (5.3%). Reproducible total cell and mast cell counts were obtained from brushings taken from two lobar bronchi (ICC 0.86). Mast cells were significantly elevated in asthmatic compared with nonasthmatic subjects (1.5 ± 0.34 versus 0.15 ± 0.06%). Allergic asthmatic subjects had the greatest numbers of mast cells (1.86 ± 0.48%); however, the numbers present in brushings from nonallergic asthmatic subjects were also increased (1.03 ± 0.45%). The mast cells had the staining characteristics of mucosal mast cells, with formalin-blockable metachromatic staining and positive staining for tryptase. Both asthmatic groups also had elevated BAL eosinophils, and neutrophils were elevated in nonallergic asthmatic subjects. We conclude that bronchial brushings are a useful technique for sampling intraepithelial mast cells and that there is an accumulation of mast cells within the airway epithelium in asthma that is independent of allergy. The microenvironment within the bronchial epithelium may favor mast cell accumulation and the acquisition of a particular mast cell phenotype, which in turn may contribute to persisting airway inflammation and hyperresponsiveness in asthma.

CitationsScopus - 95
1993GIBSON PG, TALBOT PI, HANCOCK J, HENSLEY MJ, 'A PROSPECTIVE AUDIT OF ASTHMA MANAGEMENT FOLLOWING EMERGENCY ASTHMA-TREATMENT AT A TEACHING HOSPITAL', MEDICAL JOURNAL OF AUSTRALIA, 158 775-778 (1993)
Author URL
CitationsScopus - 40Web of Science - 44
Co-authorsMichael Hensley
1990HARGREAVE FE, GIBSON PG, RAMSDALE EH, 'AIRWAY HYPERRESPONSIVENESS, AIRWAY INFLAMMATION, AND ASTHMA', IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA, 10 439-448 (1990)
Author URL
CitationsWeb of Science - 7
Show 396 more journal articles

Review (10 outputs)

YearCitationAltmetricsLink
2013Gibson PG, 'Asthma and Obesity, the Twin Epidemics (2013) [D2]
2004Powell HG, Gibson PG, 'High Dose versus low dose inhaled corticosteroid as initial starting dose for asthma in adults and children', ACP Journal Club (2004) [D2]
2004Wark PA, Gibson PG, Wilson AJ, 'Azoles for Allergic Bronchopulmonary Aspergillosis Associated With Asthma', Cochrane Database of Systematic Reviews (2004) [D1]
DOI10.1002/14651858.CD001108
CitationsScopus - 1
Co-authorsPeter Wark, Amanda Wilson
2004Taramarcaz P, Gibson PG, 'Intranasal Corticosteroids for Asthma control in People with Coexisting Asthma and Rhinitis', Cochrane Database of Systematic Reviews (2004) [D1]
2004Shah S, Wilson AJ, Gibson PG, Coughlan J, 'Long Acting Beta-Agonists Versus Theophylline for Maintenance Treatment of Asthma', Cochrane Database of Systematic Reviews (2004) [D1]
DOI10.1002/14651858.CD001281
CitationsScopus - 13
Co-authorsAmanda Wilson
2004Gibson PG, Powell HG, Coughlan J, Wilson AJ, Abramson M, Haywood P, et al., 'Self-Management Education and Regular Practitioner Review for Adults With Asthma', Cochrane Database of Systematic Reviews (2004) [D1]
CitationsScopus - 68
Co-authorsMichael Hensley, Amanda Wilson
2004Powell HG, Gibson PG, 'Options for Self-Management Education for Adults with Asthma', Cochrane Database of Systematic Reviews (2004) [D1]
CitationsScopus - 17
2004Gibson PG, Henry RL, Coughlan J, 'Gastro-Oesophageal Reflux Treatment for Asthma in Adults and Children', Cochrane Database of Systematic Reviews (2004) [D1]
CitationsScopus - 22
2003Lacasse Y, Brosseau L, Milne S, Gibson PG, 'Respiratory rehabilitation improves health-related quality of life in chronic obstructive pulmonary disease', A C P Journal Club (2003) [D1]
2003Wood LG, Gibson PG, Garg ML, 'Biomarkers of lipid peroxidation, airway inflammation and asthma', The European Respiratory Journal (2003) [D2]
CitationsScopus - 153Web of Science - 144
Co-authorsLisa Wood, Manohar Garg
Show 7 more reviews

Conference (283 outputs)

YearCitationAltmetricsLink
2014Upham JW, Carroll M, Gibson P, Yang IA, Simpson J, 'Anti-Viral Innate Immunity Varies Across Different Asthma Inflammatory Phenotypes', JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, San Diego, CA (2014) [E3]
Author URL
Co-authorsJodie Simpson
2014Vertigan AE, Gibson PG, Bone SL, 'Laryngeal Hypersensitivity in Chronic Refractory Cough and Paradoxical Vocal Fold Movement', LUNG (2014) [E3]
Author URL
2014Lewis A, Pretto J, Gibson P, 'UTILITY OF IMPULSE OSCILLOMETRY IN DETECTING UPPER AIRWAY DYSFUNCTION DURING HYPERTONIC SALINE CHALLENGE', RESPIROLOGY (2014) [E3]
DOI10.1111/resp.12261Author URL
2014Eckert B, Simpson J, Powell H, Pretto J, Upham J, Gibson P, 'EXHALED NITRIC OXIDE MEASUREMENT: INTER-INSTRUMENT VARIABILITY AND IMPLICATIONS ON TEST INTERPRETATION', RESPIROLOGY (2014) [E3]
DOI10.1111/resp.12262_16Author URL
Co-authorsJodie Simpson
2014Periyalil H, Scott H, Jensen M, Wood L, Gibson P, 'MACROPHAGE ACTIVATION IS A DETERMINANT OF DEVELOPMENTAL EFFECTS OF IMMUNOMETABOLISM IN OBESE ASTHMA', RESPIROLOGY (2014) [E3]
DOI10.1111/resp.12263_7Author URL
Co-authorsLisa Wood, Hayley Scott
2014Berthon B, Macdonald-Wicks L, Gibson P, Wood L, 'SHORT TERM ORAL CORTICOSTEROID THERAPY DOES NOT INCREASE APPETITE, DIETARY INTAKE, BODY WEIGHT AND BODY COMPOSITION IN ADULTS WITH ASTHMA - A RANDOMIZED-CONTROLLED TRIAL', RESPIROLOGY (2014) [E3]
Author URL
Co-authorsLisa Wood, Lesley Wicks
2014Wright T, Gibson P, Simpson J, Mcdonald V, Wood L, Baines K, 'ALARMINS IN ASTHMA AND COPD: RELATIONSHIPS TO INFLAMMATORY PHENOTYPES AND DISEASE SEVERITY', RESPIROLOGY (2014) [E3]
Author URL
Co-authorsLisa Wood, Vanessa Mcdonald, Katherine Baines, Jodie Simpson
2014Wood L, Shivappa N, Berthon B, Gibson P, Hebert J, 'DIETARY INFLAMMATORY INDEX IS RELATED TO ASTHMA RISK, LUNG FUNCTION AND SYSTEMIC INFLAMMATION IN ASTHMA', RESPIROLOGY (2014) [E3]
Author URL
CitationsWeb of Science - 1
Co-authorsLisa Wood
2014Mcdonald V, Gibson P, Scott H, Baines P, Hensley M, Pretto J, Wood L, 'SHOULD WE TREAT OBESITY IN COPD? THE EFFECTS OF WEIGHT LOSS AND RESISTANCE TRAINING IN OBESE COPD', RESPIROLOGY (2014) [E3]
Author URL
Co-authorsMichael Hensley, Lisa Wood, Hayley Scott, Vanessa Mcdonald
2014Baines K, Upham J, Yerkovich S, Chang A, Marchant J, Carroll M, et al., 'INTERLEUKIN-1B IS RELATED TO CLINICAL OUTCOMES IN PROTRACTED BACTERIAL BRONCHITIS', RESPIROLOGY (2014) [E3]
Author URL
Co-authorsKatherine Baines, Jodie Simpson
2014Eckert B, Simpson J, Powell H, Pretto J, Upham J, Gibson P, 'EXHALED NITRIC OXIDE MEASUREMENT: INTER-INSTRUMENT VARIABILITY AND IMPLICATIONS ON TESTS INTERPRETATION', RESPIROLOGY (2014) [E3]
Author URL
Co-authorsJodie Simpson
2014Simpson J, Gao P, Baines K, Yang I, Reynolds P, Hodge S, et al., 'GALECTIN 3 AND GALECTIN 3 BINDING PROTEIN IN ASTHMA INFLAMMATORY SUBTYPES', RESPIROLOGY (2014) [E3]
Author URL
Co-authorsJodie Simpson, Katherine Baines
2014Simpson J, Carroll M, Gibson P, Yang I, Reynolds P, Hodge S, et al., 'REDUCED ANTI-VIRAL INNATE IMMUNITY IN PATIENTS WITH SEVERE ASTHMA IS ASSOCIATED WITH NEUTROPHILIC INFLAMMATION AND HIGH DOSE INHALED STEROIDS', RESPIROLOGY (2014) [E3]
Author URL
Co-authorsJodie Simpson
2014Sutherland M, Gibson P, Thien F, Peters M, Upham J, Reddel H, et al., 'SEVERE REFRACTORY ALLERGIC ASTHMA IN AUSTRALIA: THE AUSTRALIAN XOLAIR REGISTRY (AXR)', INTERNAL MEDICINE JOURNAL (2014) [E3]
Author URL
2013Scott HA, Gibson PG, Garg ML, Smart J, Wood LG, 'Female Reproductive Stage Drives The Association Between Obesity And Neutrophilic Airway Inflammation In Adults With Asthma', American Journal of Respiratory and Critical Care Medicine, Philadelphia, PA (2013) [E3]
Co-authorsHayley Scott, Lisa Wood, Manohar Garg
2013Scott HA, Gibson PG, Garg ML, Smart JM, Wood LG, 'The Association Between Obesity and Asthma is Driven By Female Reproductive Stage', Australasian Medical Journal, Brisbane (2013) [E3]
Co-authorsHayley Scott, Lisa Wood, Manohar Garg
2013Jayasinha R, Brown N, Towns SM, Gibson PG, Jaffe A, Chang AB, 'Preventing tobacco smoking in disadvantaged and indigenous young people', Respirology, Darwin, NT (2013) [E3]
2013Berthon B, MacDonald-Wicks L, Gibson P, Wood L, 'Changes in body composition are associated with corticosteroid use in adult asthma', EUROPEAN RESPIRATORY JOURNAL (2013)
Author URL
Co-authorsLesley Wicks, Lisa Wood
2013Scott HA, Gibson PG, Garg ML, Smart J, Wood LG, 'REPRODUCTIVE STAGE DRIVES LINK BETWEEN OBESITY AND NEUTROPHILIC AIRWAY INFLAMMATION IN FEMALES WITH ASTHMA', RESPIROLOGY (2013) [E3]
Author URL
Co-authorsHayley Scott, Lisa Wood, Manohar Garg
2013Fu JJ, Mcdonald VM, Simpson JL, Higgins I, Mao B, Gibson PG, 'VALIDATION OF THE NEW GOLD COMBINED ASSESSMENT IN AN AUSTRALIAN COPD COHORT', RESPIROLOGY (2013) [E3]
Author URL
Co-authorsJodie Simpson, Isabel Higgins, Vanessa Mcdonald
2013Mattes J, Murphy V, Powell H, Gibson P, 'THE EFFECT OF BETTER ASTHMA CONTROL IN PREGNANCY ON WHEEZY ILLNESSES IN INFANCY', RESPIROLOGY (2013) [E3]
Author URL
CitationsWeb of Science - 1
Co-authorsVanessa Murphy, Joerg Mattes
2013Forbes RL, Gibson PG, Murphy VE, Wark PA, 'H1N1PDM09 ALTERS MATERNAL IMMUNITY DURING PREGNANCY', RESPIROLOGY (2013) [E3]
Author URL
Co-authorsVanessa Murphy, Peter Wark
2013Gunawardhana LP, Baines KJ, Mattes J, Murphy VE, Simpson JL, Gibson PG, 'EPIGENETIC ALTERATIONS IN INFANTS ASSOCIATED WITH MATERNAL ASTHMA DURING PREGNANCY', RESPIROLOGY (2013) [E3]
Author URL
Co-authorsJodie Simpson, Vanessa Murphy, Joerg Mattes, Katherine Baines
2013Horvat JC, Essilfie A-T, Kim RY, Mayall JR, Starkey MR, Beckett EL, et al., 'MACROLIDES SUPPRESS KEY FEATURES OF EXPERIMENTAL STEROID-SENSITIVE AND STEROID-RESISTANT ASTHMA', RESPIROLOGY (2013) [E3]
Author URL
CitationsScopus - 1
Co-authorsPhilip Hansbro, Malcolm Starkey, Paul Foster, Jay Horvat
2013Powell H, Garside CG, Simpson JL, Yang IA, Reynolds PN, Hodge SJ, et al., 'CHARACTERISTICS OF UNCONTROLLED ASTHMA IN AUSTRALIA', RESPIROLOGY (2013) [E3]
Author URL
Co-authorsJodie Simpson
2013Simpson JL, Yang IA, Reynolds PN, Hodge SJ, James AL, Upham J, et al., 'ALTERNATIVES TO INDUCED SPUTUM FOR IDENTIFYING PATIENTS WITH EOSINOPHILIC ASTHMA', RESPIROLOGY (2013) [E3]
Author URL
Co-authorsJodie Simpson
2013Simpson JL, Baines KJ, Ryan NM, Gibson PG, 'NEUTROPHILIC ASTHMA IS CHARACTERIZED BY INCREASED GERD AND RHINOSINUSITIS WITH SLEEP DISTURBANCE', RESPIROLOGY (2013) [E3]
Author URL
Co-authorsNicole Ryan, Katherine Baines, Jodie Simpson
2013Berthon BS, Macdonald-Wicks LK, Gibson PG, Wood LG, 'PARTIAL OR POOR ASTHMA CONTROL IS RELATED TO ANXIETY AND DEPRESSION SCORES', RESPIROLOGY (2013) [E3]
Author URL
Co-authorsLesley Wicks, Lisa Wood
2013Baines KJ, Simpson JL, Mcdonald VM, Hsu AC, Gibson PG, 'DIFFERENTIAL AIRWAY GENE EXPRESSION IN COPD', RESPIROLOGY (2013) [E3]
Author URL
Co-authorsVanessa Mcdonald, Katherine Baines, Jodie Simpson, Alan Hsu
2013Mcdonald VM, Wood LG, Baines P, Higgins I, Gibson PG, 'OBESITY IN COPD PROTECTIVE FOR OSTEOPOROSIS?', RESPIROLOGY (2013) [E3]
Author URL
Co-authorsLisa Wood, Vanessa Mcdonald, Isabel Higgins
2013Wang G, Baines KJ, Fu JJ, Gibson PG, 'MAST CELL-BASED PHENOTYPES OF ASTHMA IN INDUCED SPUTUM SAMPLES', RESPIROLOGY (2013) [E3]
Author URL
Co-authorsKatherine Baines
2012Scott HA, Gibson PG, Garg ML, Smart JM, Wood LG, 'Female reproductive stage drives the association between obesity and neutrophilic airway inflammation in adults with asthma', Abstracts. American Thoracic Society 2012 International Conference, San Francisco, CA (2012) [E3]
Co-authorsHayley Scott, Lisa Wood, Manohar Garg
2012Jensen ME, Gibson PG, Collins CE, Wood LG, 'Distribution of lean and fat mass differentially affect lung function in children', Abstracts. American Thoracic Society 2012 International Conference, San Francisco, CA (2012) [E3]
Co-authorsClare Collins, Lisa Wood
2012Jensen ME, Gibson PG, Collins CE, Wood LG, 'Systemic inflammation and clinical asthma outcomes in obese and non-obese children: A cross-sectional study', Abstracts. American Thoracic Society 2012 International Conference, San Francisco, CA (2012) [E3]
Co-authorsClare Collins, Lisa Wood
2012Fu J, McDonald VM, Gibson PG, Simpson JL, 'Systemic inflammation in older adults with asthma-COPD overlap syndrome', Abstracts. European Respiratory Society Annual Congress 2012, Vienna (2012) [E3]
Co-authorsJodie Simpson, Vanessa Mcdonald
2012Scott HA, Gibson PG, Garg ML, Smart JM, Wood LG, 'Reproductive stage drives link between obesity and neutrophilic airway inflammation in females with asthma', Abstracts. TSANZ Annual Scientific Meeting 2012, Canberra, ACT (2012) [E3]
Co-authorsLisa Wood, Hayley Scott, Manohar Garg
2012Ryan NM, Gibson PG, 'Gabapentin for idiopathic chronic cough: A randomised controlled trial', Lung, New York, NY (2012) [E3]
Co-authorsNicole Ryan
2012Simpson JL, Phipps S, Baines KJ, Oreo KM, Gibson PG, 'NALP3 INFLAMMASOME ACTIVATION IN NEUTROPHILIC ASTHMA', RESPIROLOGY (2012) [E3]
Author URL
Co-authorsJodie Simpson, Katherine Baines
2012Garside CG, Simpson JL, Yang IA, Reynolds PN, Hodge SJ, James AL, et al., 'Inflammatory subtypes of uncontrolled asthma in Australia', Respirology, Canberra, ACT (2012) [E3]
Co-authorsJodie Simpson
2012McDonald VM, Fu J, Simpson JL, Gibson PG, 'The longitudinal determinants of decline in obstructive airway diseases', Respirology, Canberra, ACT (2012) [E3]
Co-authorsVanessa Mcdonald, Jodie Simpson
2012McDonald VM, Wark PA, Roberts M, Spencer LM, Alison JA, Wood LG, Gibson PG, 'Development and audience testing of a COPD education DVD', Respirology, Canberra, ACT (2012) [E3]
Co-authorsLisa Wood, Vanessa Mcdonald, Peter Wark
2012Parsons KS, Tooze MK, Grissell TV, Bell N, Chapman JN, Ryan J, et al., 'Patterns (2007-2009) of respiratory viruses isolated from acute exacerbations of airways disease', Respirology, Canberra, ACT (2012) [E3]
Co-authorsPeter Wark
2012Powell HG, McCaffery K, Murphy VE, Giles W, Clifton VL, Hensley MJ, Gibson PG, 'Psychosocial outcomes are related to future exacerbation risk and perinatal outcomes in pregnant women with asthma', Respirology, Canberra, ACT (2012) [E3]
CitationsWeb of Science - 1
Co-authorsVanessa Murphy, Vicki Clifton, Michael Hensley
2012Simpson JL, Phipps S, Baines KJ, Oreo K, Gibson PG, 'NALP3 inflammasome activation in neutrophilic asthma', Respirology, Canberra, ACT (2012) [E3]
Co-authorsJodie Simpson, Katherine Baines
2012Suthers BG, McDonald VM, Gibson PG, 'Leptin is associated with breathlessness in obstructive airways disease (OAD)', Respirology, Canberra, ACT (2012) [E3]
Co-authorsVanessa Mcdonald
2012Wark PA, Tooze MK, Cheese L, Whitehead BF, Gibson PG, McDonald VM, 'Viral infections trigger CF exacerbations and worsen infection with P Aeruginosa in adults and children', Respirology, Canberra, ACT (2012) [E3]
Co-authorsPeter Wark, Vanessa Mcdonald
2012Wood LG, Garg ML, Smart JM, Scott HA, Barker D, Gibson PG, 'Manipulating antioxidant intake in asthma: A randomized clinical trial', Respirology, Canberra, ACT (2012) [E3]
CitationsWeb of Science - 2
Co-authorsLisa Wood, Manohar Garg, Hayley Scott
2012Gao P, Wang L, Zhang J, Wang F, Gibson PG, 'Inflammatory cellular phenotypes in adults with acute exacerbations of chronic obstructive pulmonary disease', Respirology, Hong Kong (2012) [E3]
2012Brooks CR, Gibson PG, Douwes J, Van Dalen CJ, Simpson JL, 'Assessment of the relationship between airway neutrophilia and aging in asthmatics and non-asthmatics', Respirology, Hong Kong (2012) [E3]
Co-authorsJodie Simpson
2012Baines KJ, Simpson JL, Wood LG, Scott RJ, Gibson PG, 'Sputum gene expression of mast cell specific proteases are increased in eosinophilic asthma', Respirology, Canberra, ACT (2012) [E3]
Co-authorsLisa Wood, Jodie Simpson, Rodney Scott, Katherine Baines
2012Baines KJ, Simpson JL, Wood LG, Scott RJ, Gibson PG, 'Induced sputum differential gene expression implicates increased p38 signalling activity in severe asthma', Respirology, Canberra, ACT (2012) [E3]
Co-authorsRodney Scott, Jodie Simpson, Lisa Wood, Katherine Baines
2012Scott HA, Gibson PG, Garg ML, Pretto JJ, Morgan PJ, Callister R, Wood LG, 'Weight loss improves clinical asthma outcomes and airway inflammation in overweight and obese asthmatics', Obesity Research & Clinical Practice, Auckland, New Zealand (2012) [E3]
Co-authorsLisa Wood, Philip Morgan, Manohar Garg, Robin Callister, Hayley Scott
2011Berthon B, MacDonald-Wicks LK, Gibson PG, Wood LG, 'Asthmatics have an altered eating pattern with increased fat and decreased fibre intake associated with airway inflammation and poorer lung function', Australasian Medical Journal, Queenstown, NZ (2011) [E3]
Co-authorsLesley Wicks, Lisa Wood
2011Berthon B, MacDonald-Wicks LK, Gibson PG, Wood LG, 'Plasma leptin levels are elevated in stable asthma', Australasian Medical Journal, Queenstown, NZ (2011) [E3]
Co-authorsLesley Wicks, Lisa Wood
2011Jensen ME, Collins CE, Gibson PG, Hilton JM, Wood LG, 'Dietary induced weight loss improves asthma control and lung function after 10 weeks in obese children and adolescents with asthma', Australasian Medical Journal, Queenstown, NZ (2011) [E3]
Co-authorsClare Collins, Lisa Wood
2011Jensen ME, Gibson PG, Collins CE, Wood LG, 'Lean mass is positively associated with respiratory function in male asthmatic children', Australasian Medical Journal, Queenstown, NZ (2011) [E3]
Co-authorsClare Collins, Lisa Wood
2011Scott HA, Gibson PG, Garg ML, Pretto JJ, Morgan PJ, Callister R, Wood LG, 'The influence of body composition and inflammation on lung function in asthma', Australasian Medical Journal, Queenstown, NZ (2011) [E3]
Co-authorsPhilip Morgan, Robin Callister, Manohar Garg, Hayley Scott, Lisa Wood
2011Baines KJ, Simpson JL, Scott R, Wood LG, Gibson PG, 'Systemic upregulation of neutrophil a-defensins and serine proteases in neutrophilic asthma', European Respiratory Society Annual Congress 2011 Abstracts, Amsterdam (2011) [E3]
Co-authorsRodney Scott, Jodie Simpson, Lisa Wood, Katherine Baines
2011Baines KJ, Simpson JL, Scott R, Wood LG, Gibson PG, 'Sputum gene expression of mast cell tryptase and carboxypeptidase A3 are increased in eosinophilic asthma', European Respiratory Society Annual Congress 2011 Abstracts, Amsterdam (2011) [E3]
Co-authorsKatherine Baines, Rodney Scott, Jodie Simpson, Lisa Wood
2011Baines KJ, Simpson JL, Scott R, Wood LG, Gibson PG, 'Induced sputum differential gene expression implicates increased p38 signalling activity in severe asthma', European Respiratory Society Annual Congress 2011 Abstracts, Amsterdam (2011) [E3]
Co-authorsLisa Wood, Rodney Scott, Jodie Simpson, Katherine Baines
2011Porsbjerg C, Gibson PG, Pretto JJ, Salome C, Brown N, King G, 'Airway inflammation and airway pathophysiology in older asthmatics', European Respiratory Society Annual Congress 2011 Abstracts, Amsterdam (2011) [E3]
2011Namazy JA, Murphy VE, Powell H, Gibson PG, Chambers C, Schatz M, 'Effects of asthma severity and medication use on prematurity and intrauterine growth: A meta analysis from published data', Journal of Allergy and Clinical Immunology, San Francisco, CA (2011) [E3]
Co-authorsVanessa Murphy
2011Gibson PG, Powell H, Giles W, Clifton V, Hensley MJ, Taylor DR, et al., 'Asthma exacerbations during pregnancy are reduced by inflammometry (FENO) guided asthma management: A randomised controlled trial', American Journal of Respiratory and Critical Care Medicine, Denver, CO (2011) [E3]
Co-authorsMichael Hensley, Vanessa Murphy
2011Hansbro PM, Horvat JC, Essilfie A-T, Kim RY, Simpson JL, Dunkley ML, et al., 'Infection-induced neutrophilic allergic airways disease is resistant to steroid treatment', American Journal of Respiratory and Critical Care Medicine, Denver, CO (2011) [E3]
Co-authorsMargaret Dunkley, Philip Hansbro, Jodie Simpson, Paul Foster, Jay Horvat
2011Jensen ME, Collins CE, Gibson PG, Hilton JM, Wood LG, 'Characterising the obese phenotype in asthmatic children and adolescents', American Journal of Respiratory and Critical Care Medicine, Denver, CO (2011) [E3]
Co-authorsClare Collins, Lisa Wood
2011Jensen ME, Gibson PG, Collins CE, Hilton JM, Latham-Smith F, Wood LG, 'Gender differences in sleep duration & sleep quality in children with & without asthma using polysomnography', American Journal of Respiratory and Critical Care Medicine, Denver, CO (2011) [E3]
Co-authorsLisa Wood, Clare Collins
2011Jensen ME, Gibson PG, Collins CE, Hilton JM, Wood LG, 'Results from a ten week pilot weight loss intervention in obese asthmatic children and adolescents', American Journal of Respiratory and Critical Care Medicine, Denver, CO (2011) [E3]
Co-authorsLisa Wood, Clare Collins
2011Scott HA, Gibson PG, Garg ML, Pretto JJ, Morgan PJ, Callister R, Wood LG, 'Clinical asthma outcomes are improved after body fat reduction in overweight and obese asthmatics', American Journal of Respiratory and Critical Care Medicine, Denver, CO (2011) [E3]
Co-authorsRobin Callister, Manohar Garg, Hayley Scott, Philip Morgan, Lisa Wood
2011Sukkar MB, Wood LG, Tooze MK, Simpson JL, McDonald VM, Gibson PG, Wark PA, 'Deficiency of srage in asthma and COPD is selectively associated with neutrophilic airway inflammation', American Journal of Respiratory and Critical Care Medicine, Denver, CO (2011) [E3]
Co-authorsVanessa Mcdonald, Jodie Simpson, Peter Wark, Lisa Wood
2011Wood LG, Scott HA, Gibson PG, 'Systemic inflammation is increased in neutrophilic asthma', American Journal of Respiratory and Critical Care Medicine, Denver, CO (2011) [E3]
Co-authorsLisa Wood, Hayley Scott
2011Scott HA, Gibson PG, Garg ML, Pretto JJ, Morgan PJ, Callister R, Wood LG, 'Success in a weight loss trial is greatest in subjects with more severe asthma', American Journal of Respiratory and Critical Care Medicine, Denver, CO (2011) [E3]
Co-authorsLisa Wood, Hayley Scott, Robin Callister, Philip Morgan, Manohar Garg
2011Vertigan AE, Gibson PG, 'Development of a brief speech pathology intervention for chronic refractory cough', Pulmonary Pharmacology & Therapeutics, London (2011) [E3]
2011McLaughlin KM, Mattes J, Murphy VE, Steel KR, Powell H, Gibson PG, 'The Growing Into Asthma (GIA) Study: Need for improved management of respiratory illnesses in early life', PSANZ 2011 15th Annual Congress: Poster Abstracts, Hobart, TAS (2011) [E3]
Co-authorsVanessa Murphy, Joerg Mattes
2011McDonald VM, Higgins IJ, Wood LG, Gibson PG, 'Multidimensional assessment and individualized management (MDAIM) of obstructive airway diseases (OAD) in older adults - A pilot clinical trial', Respirology, Perth, WA (2011) [E3]
Co-authorsIsabel Higgins, Lisa Wood, Vanessa Mcdonald
2011Sukkar M, Wood LG, Tooze MK, Simpson JL, McDonald VM, Gibson PG, Wark PA, 'Soluble RAGE is deficient in neutrophilic asthma and COPD', Respirology, Perth, WA (2011) [E3]
DOI10.1183/09031936.00022011
CitationsScopus - 45Web of Science - 39
Co-authorsPeter Wark, Lisa Wood, Vanessa Mcdonald, Jodie Simpson
2011Baines KJ, Simpson JL, Scott R, Wood LG, Gibson PG, 'Analysis of systemic gene expression according to inflammatory phenotype of asthma', Respirology, Perth, WA (2011) [E3]
Co-authorsLisa Wood, Katherine Baines, Jodie Simpson, Rodney Scott
2011Berthon B, MacDonald-Wicks LK, Gibson PG, Wood LG, 'Diet quality is poor in severe asthmatics compared to healthy controls', Respirology, Perth, WA (2011) [E3]
Co-authorsLisa Wood, Lesley Wicks
2011Vanders RL, Gibson PG, Murphy VE, Wark PA, 'Reduced antiviral interferons during pregnancy explains susceptibility to influenza virus infection', Respirology, Perth, WA (2011) [E3]
Co-authorsVanessa Murphy, Peter Wark
2011Garside CG, Simpson JL, Yang IA, James AL, Upham JW, Reynolds PN, et al., 'Characterizing the severe asthma phenotype in an Australian setting: The Amazes Study', Respirology, Perth, WA (2011) [E3]
Co-authorsJodie Simpson
2011Gunawardhana LP, Baines KJ, Simpson JL, Mattes J, Murphy VE, Gibson PG, 'Maternal asthma is associated with alterations in DNA methylation profile of peripheral blood of infants', Respirology, Perth, WA (2011) [E3]
Co-authorsVanessa Murphy, Joerg Mattes, Jodie Simpson, Katherine Baines
2011Hodge S, Richard S, Simpson JL, Garside CG, Herewane K, Yang I, et al., 'Granzyme B is increased in induced sputum both from patients with COPD and non-eosinophilic asthma', Respirology, Perth, WA (2011) [E3]
Co-authorsJodie Simpson
2011Hodge S, Simpson JL, Richard S, Garside CG, Yang I, Upham J, et al., 'Non-eosinophilic asthma resembles COPD with suppressed apoptotic cell clearance and macrophage recognition molecules', Respirology, Perth, WA (2011) [E3]
Co-authorsJodie Simpson
2011Horvat JC, Essilfie A-T, Kim RY, Simpson JL, Dunkley ML, Beagley KW, et al., 'Investigation of infection-induced steroid resistant asthma', Respirology, Perth, WA (2011) [E3]
Co-authorsPaul Foster, Jay Horvat, Jodie Simpson, Margaret Dunkley, Philip Hansbro
2011Mattes J, Murphy VE, McLaughlin KM, Steel KR, Powell H, Gibson PG, 'Are maternal asthma exacerbations during pregnancy related to impaired infant growth in the first six months of life?', Respirology, Perth, WA (2011) [E3]
Co-authorsVanessa Murphy, Joerg Mattes
2011Oreo K, Baines KJ, Gibson PG, Hansbro PM, 'Pro-inflammatory cytokine production is impaired in response to TLR2 activation in healthy ageing and COPD', Respirology, Perth, WA (2011) [E3]
Co-authorsKatherine Baines, Philip Hansbro
2011Ryan NM, Vertigan AE, Ferguson JK, Wark PA, Gibson PG, 'Investigation and characterization of persistent cough associated with H1N1 2009 influenza', Respirology, Perth, WA (2011) [E3]
Co-authorsNicole Ryan, Peter Wark, John Ferguson
2011Scott HA, Gibson PG, Garg ML, Pretto JJ, Morgan PJ, Callister R, Wood LG, 'Success in a weight loss trial is related to asthma severity', Respirology, Perth, WA (2011) [E3]
Co-authorsPhilip Morgan, Robin Callister, Manohar Garg, Hayley Scott, Lisa Wood
2011Scott HA, Gibson PG, Garg ML, Pretto JJ, Morgan PJ, Callister R, Wood LG, 'Body fat reduction improves clinical asthma outcomes in overweight and obese asthma', Respirology, Perth, WA (2011) [E3]
Co-authorsLisa Wood, Philip Morgan, Robin Callister, Manohar Garg, Hayley Scott
2011Wood LG, Scott HA, Gibson PG, 'The neutrophilic inflammatory phenotype is associated increased systemic inflammation in asthma', Respirology, Perth, WA (2011) [E3]
Co-authorsHayley Scott, Lisa Wood
2011Wang F, Xy HA, Baines KJ, Gunawardhana LP, Simpson JL, Ki F, Gibson PG, 'Is chalamydophyla a pneumoniae infection related to non-eosinophilic asthma?', Respirology, Perth, WA (2011) [E3]
Co-authorsJodie Simpson, Katherine Baines
2011Fu J, Baines KJ, Wood LG, Scott HA, Gibson PG, 'Low-grade systemic inflammation is associated with airway neutrophilia in asthma', Respirology, Shanghai (2011) [E3]
Co-authorsKatherine Baines, Hayley Scott, Lisa Wood
2011Fu J, Baines KJ, Gibson PG, Scott HA, Wood LG, 'Systemic inflammation mediates airway neutrophilia via the regulation of IL-8 receptor mRNA expression', Respirology, Shanghai (2011) [E3]
Co-authorsKatherine Baines, Hayley Scott, Lisa Wood
2011McDonald VM, Simpson JL, Higgins IJ, Gibson PG, 'Mucus hypersecretion and chronic bronchitis in older adults with chronic obstructive airway diseases', Respirology, Shanghai (2011) [E3]
Co-authorsVanessa Mcdonald, Isabel Higgins, Jodie Simpson
2011Gao P, Zhang J, He X, Wang K, Hao Y, Liu H, Gibson PG, 'The safety of sputum induction in adults with acute exacerbation of COPD', Respirology, Shanghai (2011) [E3]
2011Wood LG, Garg ML, Gibson PG, 'Dietary fat increases airway inflammation and attenuates bronchodilator response in asthma', XI Asian Congress of Nutrition 2011, Singapore (2011) [E3]
Co-authorsManohar Garg, Lisa Wood
2010Scott HA, Gibson PG, Garg ML, Smart JM, Wood LG, 'Fatty acids and obesity differentially affect airway inflammation in males and females with asthma', American Journal of Respiratory and Critical Care Medicine, New Orleans (2010) [E3]
Co-authorsHayley Scott, Lisa Wood, Manohar Garg
2010Murphy VE, Namazy JA, Powell GH, Gibson PG, Chambers C, Attia JR, Schatz M, 'A meta-analysis of adverse perinatal outcomes in asthmatic women: Effect of asthma on placental and neonatal outcomes', American Journal of Respiratory and Critical Care Medicine, New Orleans (2010) [E3]
Co-authorsJohn Attia, Vanessa Murphy
2010Hansbro PM, Essilfie A-T, Simpson JL, Dunkley ML, Horvat JC, Gibson PG, Foster PS, 'Haemophilus influenzae induces IL-17-mediated neutrophilic allergic airways disease', American Journal of Respiratory and Critical Care Medicine, New Orleans (2010) [E3]
CitationsScopus - 37Web of Science - 34
Co-authorsJay Horvat, Margaret Dunkley, Philip Hansbro, Jodie Simpson, Paul Foster
2010Thorburn AN, Foster PS, Gibson PG, Hansbro PM, 'Development of a streptococcus pneumoniae-based immunoregulatory therapy for asthma', American Journal of Respiratory and Critical Care Medicine, New Orleans (2010) [E3]
Co-authorsPhilip Hansbro, Paul Foster
2010Thorburn AN, Foster PS, Gibson PG, Hansbro PM, 'Streptococcus pneumoniae vaccine, prevenar, induces regulatory T cells and prevents allergic airways disease', American Journal of Respiratory and Critical Care Medicine, New Orleans (2010) [E3]
Co-authorsPaul Foster, Philip Hansbro
2010Wood LG, Garg ML, Wood A, Gibson PG, 'A high fat challenge enhances innate immune responses in asthmatic airways', American Journal of Respiratory and Critical Care Medicine, New Orleans (2010) [E3]
Co-authorsLisa Wood, Manohar Garg
2010Namazy JA, Murphy VE, Powell HG, Gibson PG, Chambers CD, Schatz M, 'Congenital anomalies in asthmatic women using corticosteroids during pregnancy: A meta analysis from published data', Birth Defects Research (Part A), Louisville, KT (2010) [E3]
Co-authorsVanessa Murphy
2010Scott HA, Gibson PG, Garg ML, Pretto JJ, Morgan PJ, Callister R, Wood LG, 'Caloric restriction and exercise improve clinical asthma outcomes in overweight and obese asthma', Obesity Research & Clinical Practice, Sydney, NSW (2010) [E3]
Co-authorsLisa Wood, Hayley Scott, Philip Morgan, Robin Callister, Manohar Garg
2010Jensen ME, Gibson PG, Collins CE, Hilton JM, Wood LG, 'Body composition may be associated with systemic and airway inflammation in children with asthma', Obesity Research and Clinical Practice, Sydney, NSW (2010) [E3]
Co-authorsLisa Wood, Clare Collins
2010Scott HA, Gibson PG, Garg ML, Pretto JJ, Morgan PJ, Callister R, Wood LG, 'Caloric consumption and exercise improve clinical asthma outcomes in overweight and obese asthma', Obesity Research and Clinical Practice, Sydney, NSW (2010) [E3]
Co-authorsLisa Wood, Hayley Scott, Robin Callister, Philip Morgan, Manohar Garg
2010Hodyl NA, Smith R, Bisits AM, Gibson PG, Clifton VL, 'The effect of inhaled corticosteroids on maternal and fetal systemic function and placental activity in women with asthma', Reproductive Sciences, Orlando, Florida (2010) [E3]
DOI10.1177/193371912010173s003
Co-authorsRoger Smith, Vicki Clifton
2010Irwin J, Verrills NM, He XY, Powell H, Wood LG, Gibson PG, 'Proteomic biomarkers as novel clinical diagnostics for airway disease', Abstract Book. Human Proteome World Congress Sydney 2010, Sydney, NSW (2010) [E3]
Co-authorsNikki Verrills, Lisa Wood
2010Baines KJ, Simpson JL, Scott R, Wood LG, Gibson PG, 'Molecular phenotypes of asthma defined by gene expression profiling', American Journal of Respiratory and Critical Care Medicine, New Orleans, LO (2010) [E3]
Co-authorsKatherine Baines, Rodney Scott, Jodie Simpson, Lisa Wood
2010Baines KJ, Simpson JL, Scott R, Wood LG, Gibson PG, 'Analysis of systemic gene expression according to inflammatory phenotype of asthma', Biomarker Discovery Conference, Shoal Bay, NSW (2010) [E3]
Co-authorsLisa Wood, Rodney Scott, Jodie Simpson, Katherine Baines
2010Scott HA, Gibson PG, Garg ML, Pretto JJ, Morgan PJ, Callister R, Wood LG, 'Clinical asthma outcomes are improved by caloric restriction and exercise in overweight and obese asthma', Proceedings of the Nutrition Society of Australia, Perth (2010) [E3]
Co-authorsLisa Wood, Hayley Scott, Manohar Garg, Philip Morgan, Robin Callister
2010McDonald VM, Higgins IJ, Simpson JL, Gibson PG, 'Is there an association between self reported activity limitation and exercise tolerance in COPD?', European Respiratory Society Annual Congress 2010. Abstracts, Barcelona, Spain (2010) [E3]
Co-authorsJodie Simpson, Vanessa Mcdonald, Isabel Higgins
2010McDonald VM, Higgins IJ, Simpson JL, Gibson PG, 'Six minute walk tests: Are practice tests necessary?', European Respiratory Society Annual Congress 2010. Abstracts, Barcelona, Spain (2010) [E3]
Co-authorsIsabel Higgins, Jodie Simpson, Vanessa Mcdonald
2010McDonald VM, Higgins IJ, Wood LG, Gibson PG, 'Multidimensional assessment and individualised management of obstructive airway diseases (OAD) in older adults', European Respiratory Society Annual Congress 2010. Abstracts, Barcelona, Spain (2010) [E3]
Co-authorsIsabel Higgins, Lisa Wood, Vanessa Mcdonald
2010Namazy JA, Murphy VE, Powell HG, Gibson PG, Chambers C, Schatz M, 'Adverse perinatal outcomes in asthmatic women: A meta analysis from published data', Journal of Allergy and Clinical Immunology, New Orleans, LA (2010) [E3]
Co-authorsVanessa Murphy
2010McLaughlin KM, Steel KR, McCaffery K, Powell HG, Clifton VL, Giles W, et al., 'Psychosocial characteristics and perceived medication risk in pregnant women and asthma', Journal of Paediatrics and Child Health: Abstracts of the 14th Annual Congress of the Perinatal Society of Australia and New Zealand 2010, Wellington, NZ (2010) [E3]
Co-authorsVicki Clifton, Michael Hensley
2010Vanders RL, Gibson PG, Murphy VE, Wark PA, 'Reduced anti-viral responses: Why pregnant women have increased susceptibility to respiratory virus infection', American Journal of Respiratory and Critical Care Medicine, New Orleans, LO (2010) [E3]
Co-authorsVanessa Murphy, Peter Wark
2010Baines KJ, Simpson JL, Scott RJ, Wood LG, Gibson PG, 'Molecular profiling of asthma defined by gene expression', Respirology, Brisbane, QLD (2010) [E3]
Co-authorsJodie Simpson, Katherine Baines, Lisa Wood
2010Baines KJ, Simpson JL, Scott R, Wood LG, Gibson PG, 'Molecular phenotypes of asthma defined by gene expression profiling', Respirology, Brisbane, QLD (2010) [E3]
Co-authorsLisa Wood, Rodney Scott, Jodie Simpson, Katherine Baines
2010Vanders RL, Gibson PG, Murphy VE, Wark PA, 'Reduced anti-viral responses: Why pregnant women have increased susceptiblty to respiratory virus infection', Respirology, Brisbane, QLD (2010) [E3]
Co-authorsVanessa Murphy, Peter Wark
2010Jensen ME, Collins CE, Gibson PG, Hilton JM, Wood LG, 'Obesity is associated with increased airway inflammation in children with asthma', Respirology, Brisbane, QLD (2010) [E3]
Co-authorsLisa Wood, Clare Collins
2010McDonald VM, Simpson JL, Higgins IJ, Gibson PG, 'Is there an association between self reported acitivity limitation and exercise tolerance in COPD?', Respirology, Brisbane, QLD (2010) [E3]
Co-authorsIsabel Higgins, Vanessa Mcdonald, Jodie Simpson
2010Murphy VE, Namazy J, Powell GH, Gibson PG, Chambers C, Attia JR, Schatz M, 'A meta-analysis of adverse perinatal outcomes in asthmatic women: Effect of asthma on maternal and neonatal outcomes', Respirology, Brisbane, QLD (2010) [E3]
Co-authorsVanessa Murphy, John Attia
2010Murphy VE, Namazy J, Powell GH, Schatz M, Chambers C, Attia JR, Gibson PG, 'A meta-analysis of adverse perinatal outcomes in asthmatic women: Effect of asthma on size at birth and timing of birth', Respirology, Brisbane, QLD (2010) [E3]
Co-authorsVanessa Murphy, John Attia
2010Ryan NM, Vertigan AE, Bone S, Gibson PG, 'Cough reflex sensitivity improves with speech language pathology management of refractory chronic cough', Respirology, Brisbane, QLD (2010) [E3]
DOI10.1186/1745-9974-6-5
Co-authorsNicole Ryan
2010Simpson JL, McDonald VM, Gibson PG, 'The relationship between systemic inflammation, airway inflammation and airway obstruction in COPD', Respirology, Brisbane, QLD (2010) [E3]
Co-authorsVanessa Mcdonald, Jodie Simpson
2010Simpson JL, McDonald VM, Gibson PG, 'Exhaled nitric oxide is not a marker of eosinophilic inflammation in older Australians', Respirology, Brisbane, QLD (2010) [E3]
Co-authorsVanessa Mcdonald, Jodie Simpson
2010Steel KR, McLaughlin KM, McCaffery K, Powell GH, Clifton VL, Giles W, et al., 'Psychosocial characteristics and perceived medication risk in pregnant women with asthma', Respirology, Brisbane, QLD (2010) [E3]
Co-authorsMichael Hensley
2010Wood LG, Garg ML, Wood A, Gibson PG, 'Dietary fat enhances airway inflammation in asthma', Respirology, Brisbane, QLD (2010) [E3]
Co-authorsManohar Garg, Lisa Wood
2010Yan X, He S, Gangireddy SR, Gibson PG, Wark PA, 'Monocyte derived dendritic cells from COPD patients and their therapeutic potential', Respirology, Brisbane, QLD (2010) [E3]
Co-authorsPeter Wark
2010Jensen ME, Collins CE, Gibson PG, Hilton JM, Wood LG, 'Obesity affects airway inflammation in asthmatic children', Nutrition & Dietetics, Melbourne (2010) [E3]
Co-authorsClare Collins, Lisa Wood
2009Baines KJ, Simpson JL, Scott R, Wood LG, Gibson PG, 'Genome wide gene expression of induced sputum in non-eosinophilic asthma', AMATA 2009, Katoomba, NSW (2009) [E3]
Co-authorsJodie Simpson, Lisa Wood, Rodney Scott, Katherine Baines
2009Hansbro PM, Starkey MR, Horvat JC, Kim RY, Phipps S, Gibson PG, Foster PS, 'Early life chlamydial infection enhances allergic airways disease through age-dependent differences in immunopathology', Journal of Immunology, Seattle, WASH. (2009) [E3]
DOI10.1016/j.jaci.2009.10.018
Co-authorsPhilip Hansbro, Paul Foster, Jay Horvat, Malcolm Starkey
2009Hansbro PM, Thorburn AN, Foster PS, Gibson PG, 'Streptococcus pneumoniae vaccine, Prevenar, utilises Tregs to suppress asthma', Journal of Immunology, Seattle, WASH. (2009) [E3]
Co-authorsPaul Foster, Philip Hansbro
2009Horvat JC, Starkey MR, Beagley KW, Gibson PG, Foster PS, Hansbro PM, 'Chlamydial respiratory infection predisposes to neutrophil dominated allergic airways disease (AAD)', Journal of Immunology, Seattle, WASH. (2009) [E3]
Co-authorsMalcolm Starkey, Philip Hansbro, Jay Horvat, Paul Foster
2009Scott HA, Gibson PG, Garg ML, Smart JM, Wood LG, 'Plasma fatty acid profiles are different in obese versus non-obese asthma', Proceedings of the Nutrition Society of Australia, Newcastle, NSW (2009) [E3]
Co-authorsLisa Wood, Hayley Scott, Manohar Garg
2009Wood LG, Gibson PG, 'Antioxidant defences are impaired in asthmatics with airway hyperresponsiveness, poor control and severe disease pattern', Proceedings of the Nutrition Society of Australia, Newcastle, NSW (2009) [E3]
Co-authorsLisa Wood
2009Wood AJ, Gibson PG, Wood LG, 'Effects of a high fat, high energy food challenge on mood, fatigue and gastrointestinal symptoms', Proceedings of the Nutrition Society of Australia, Newcastle, NSW (2009) [E3]
Co-authorsLisa Wood
2009McDonald VM, Wood LG, Smart JM, Higgins IJ, Gibson PG, 'Sacropenia and sarcopenic obesity in older people with COPD?', Proceedings of the Nutrition Society of Australia, Newcastle, NSW (2009) [E3]
Co-authorsIsabel Higgins, Lisa Wood, Vanessa Mcdonald
2009McDonald VM, McElduff P, Simpson JL, Higgins IJ, Gibson PG, 'Multidimensional problem assessment of asthma and COPD in an older population: Patient-physician concordance', European Respiratory Journal, Vienna, Austria (2009) [E3]
Co-authorsVanessa Mcdonald, Isabel Higgins, Jodie Simpson
2009McDonald VM, Wood LG, Smart J, Higgins I, Gibson PG, 'An Investigation of Sarcopenic Obesity in COPD.', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2009) [E3]
Author URL
Co-authorsLisa Wood, Isabel Higgins, Vanessa Mcdonald
2009Scott HA, Gibson PG, Garg ML, Smart J, Wood LG, 'Neutrophilic Airway Inflammation Links Asthma and Obesity', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2009) [E3]
Author URL
Co-authorsHayley Scott, Lisa Wood, Manohar Garg
2009McDonald VM, Wood LG, Smart JM, Higgins IJ, Gibson PG, 'Does sarcopenic obesity exist in older people with COPD?', Respirology, Darwin, NT (2009) [E3]
DOI10.1111/j.1440-1843.2009.01503_1.x
Co-authorsIsabel Higgins, Lisa Wood, Vanessa Mcdonald
2009McDonald VM, McElduff P, Simpson JL, Higgins IJ, Gibson PG, 'Multidimensional clinical problem assessment in asthma and COPD: Patient-physician concordance', Respirology, Darwin, NT (2009) [E3]
DOI10.1111/j.1440-1843.2009.01502_7.x
Co-authorsIsabel Higgins, Jodie Simpson, Vanessa Mcdonald
2009Murphy VE, Clifton VL, Gibson PG, 'The effect of cigarette smoking on asthma control and exacerbations in pregnant women', Respirology, Darwin, NT (2009) [E3]
DOI10.1111/j.1440-1843.2009.01503_1.x
Co-authorsVanessa Murphy
2009Oldham RA, Simpson JL, Hansbro PM, Gibson PG, 'Increased bacterial load and colonisation in COPD', Respirology, Darwin, NT (2009) [E3]
DOI10.1111/j.1440-1843.2009.01503_1.x
Co-authorsJodie Simpson, Philip Hansbro
2009Wark PA, Parsons KS, Ryan J, Grissell T, Bell N, Chapman JN, Gibson PG, 'Seasonal patterns (2004-2007) of respiratory viruses isolated with acute airways disease', Respirology, Darwin, NT (2009) [E3]
DOI10.1111/j.1440-1843.2009.01503_1.x
Co-authorsPeter Wark
2009Twaddell S, Loewenthal MR, Gibson PG, Saltos N, Wark PA, 'Individualised aminoglycoside dosing in adult patients with cystic fibrosis improves pharmacokinetic parameters', Respirology, Darwin, NT (2009) [E3]
DOI10.1111/j.1440-1843.2009.01503_1.x
Co-authorsPeter Wark
2009Thorburn AN, O'Sullivan B, Thomas R, Foster PS, Gibson PG, Hansbro PM, 'Prevenar suppresses allergic airways disease through the expansion of regulatory T cells', Respirology, Darwin, NT (2009) [E3]
DOI10.1111/j.1440-1843.2009.01503_1.x
Co-authorsPhilip Hansbro, Paul Foster
2009Simpson JL, Gibson PG, Reynolds PN, Hodge S, 'Impaired macrophage phagocytosis in non-eosinophilic asthma', Respirology, Darwin, NT (2009) [E3]
DOI10.1111/j.1440-1843.2009.01503_1.x
Co-authorsJodie Simpson
2009Baines KJ, Grissell TV, Gibson PG, Wark PA, 'Molecular mechanisms of rhinovirus infection of primary bronchial epithelial cells', Respirology, Darwin, NT (2009) [E3]
DOI10.1111/j.1440-1843.2009.01503_1.x
Co-authorsPeter Wark, Katherine Baines
2009Baines KJ, Wood LG, Gibson PG, 'Molecular mechanisms of airway neutrophilia following a low antioxidant diet', Respirology, Darwin, NT (2009) [E3]
DOI10.1111/j.1440-1843.2009.01503_1.x
Co-authorsKatherine Baines, Lisa Wood
2009Scott HA, Gibson PG, Garg ML, Smart JM, Wood LG, 'Asthma and obesity are linked via neutrophilic airway inflammation', Respirology, Darwin, NT (2009) [E3]
DOI10.1111/j.1440-1843.2009.01503_1.x
Co-authorsManohar Garg, Hayley Scott, Lisa Wood
2009Oreo K, Baines KJ, Gibson PG, Hansbro PM, Simpson JL, 'Toll-like receptor agonists stimulate cytokine release from blood but not airway cells', Respirology, Darwin, NT (2009) [E3]
DOI10.1111/j.1440-1843.2009.01503_1.x
Co-authorsJodie Simpson, Katherine Baines, Philip Hansbro
2009Essilfie A-T, Simpson JL, Dunkley ML, Foster PS, Gibson PG, Hansbro PM, 'Haemophilus influenzae infection induces features of neutrophilic asthma', Respirology, Darwin, NT (2009) [E3]
DOI10.1111/j.1440-1843.2009.01503_1.x
Co-authorsPhilip Hansbro, Margaret Dunkley, Jodie Simpson, Paul Foster
2009Thomas R, Ferguson JK, Gibson PG, 'Community acquired methicillin resistant staphylococcus aureus pneumonia: A clinical audit', Respirology, Darwin, NT (2009) [E3]
DOI10.1111/j.1440-1843.2009.01502_7.x
Co-authorsJohn Ferguson
2009Powell H, Murphy VE, Gibson PG, 'The relationship between feno and atopic status in pregnant women with asthma', Respirology, Darwin, NT (2009) [E3]
DOI10.1111/j.1440-1843.2009.01503_1.x
Co-authorsVanessa Murphy
2009Wood LG, Garg ML, Smith AJ, Smart JM, Gibson PG, 'A high fat, high energy food challenge induces an exaggerated inflammatory response in asthma', Respirology, Darwin, NT (2009) [E3]
DOI10.1111/j.1440-1843.2009.01503_1.x
Co-authorsLisa Wood, Manohar Garg
2009Horvat JC, Starkey MR, Beagley KW, Preston JA, Gibson PG, Foster PS, Hansbro PM, 'Neutrophil influx during chlamydial lung infection determines the phenotype of allergic airways disease (AAD)', Respirology, Darwin, NT (2009) [E3]
DOI10.1111/j.1440-1843.2009.01503_1.x
Co-authorsPaul Foster, Malcolm Starkey, Jay Horvat, Philip Hansbro
2009Starkey MR, Horvat JC, Kim RY, Phipps S, Gibson PG, Beagley KW, et al., 'Early life chlamydial lung infection enhances allergic airways disease through age-dependent differences in immunopathology', Respirology, Darwin, NT (2009) [E3]
DOI10.1016/j.jaci.2009.10.018
CitationsScopus - 46Web of Science - 46
Co-authorsMalcolm Starkey, Philip Hansbro, Jay Horvat, Paul Foster
2009McLaughlin KM, Murphy VE, McCaffery K, Powell H, Clifton VL, Giles W, et al., 'The relationship between patient perceived risk of inhaled corticosteroids in pregnancy and medication adherence', Respirology, Darwin, NT (2009) [E3]
Co-authorsMichael Hensley, Vanessa Murphy
2008Hansbro PM, Essilfie A-T, Foster PS, Gibson PG, 'Haemophilus influenzae (Hi) infection in asthma may drive the development of neutrophilic asthma (NA)', American Journal of Respiratory and Critical Care Medicine, Toronto, ONT (2008) [E3]
Co-authorsPhilip Hansbro, Paul Foster
2008Hansbro PM, Horvat JC, Beagley KW, Gibson PG, Foster PS, 'Neutrophil influx during chlamydial lung infection determines the phenotype of allergic airways disease', American Journal of Respiratory and Critical Care Medicine, Toronto, ONT (2008) [E3]
Co-authorsPhilip Hansbro, Paul Foster, Jay Horvat
2008Hansbro PM, Thorburn AN, Foster PS, Gibson PG, 'Streptococcus Pneumoniae vaccine prevenar: A potential therapy for the suppression of asthma', American Journal of Respiratory and Critical Care Medicine, Toronto, ONT (2008) [E3]
Co-authorsPaul Foster, Philip Hansbro
2008Simpson JL, Hansbro PM, McDonald VM, Gibson PG, 'Age and disease related changes in airway inflammation and inflammatory subtype in older people with COPD', American Journal of Respiratory and Critical Care Medicine, Toronto, ONT (2008) [E3]
Co-authorsVanessa Mcdonald, Philip Hansbro, Jodie Simpson
2008Murphy VE, Clifton VL, Gibson PG, 'Characterization of asthma control and airway inflammation during exacerbations in pregnancy', American Journal of Respiratory and Critical Care Medicine, Toronto, ONT (2008) [E3]
Co-authorsVicki Clifton, Vanessa Murphy
2008Nguyen TD, Hensley MJ, Whitehead BF, Gibson PG, 'Influence of passive smoking on airway inflammation in children with asthma', American Journal of Respiratory and Critical Care Medicine, Toronto, ONT (2008) [E3]
Co-authorsMichael Hensley
2008Nguyen TD, Hensley MJ, Whitehead BF, Gibson PG, 'Airway inflammatory phenotypes in children with asthma', American Journal of Respiratory and Critical Care Medicine, Toronto, ONT (2008) [E3]
Co-authorsMichael Hensley
2008Baines KJ, Simpson JL, Scott R, Gibson PG, 'Ageing alters airway and circulating neutrophil function', Respirology, Melbourne, VIC (2008) [E3]
DOI10.1111/j.1440-1843.2008.01252.x
Co-authorsKatherine Baines, Jodie Simpson, Rodney Scott
2008Baines KJ, Simpson JL, Scott R, Gibson PG, 'Innate immune responses of airway neutrophils are impaired in neutrophilic asthma', Respirology, Melbourne, VIC (2008) [E3]
DOI10.1111/j.1440-1843.2008.01252.x
Co-authorsRodney Scott, Jodie Simpson, Katherine Baines
2008Thorburn AN, Foster PS, Gibson PG, Hansbro PM, 'Streptococcus pneumoniae vaccine prevenar: A potential therapy for the suppression of asthma', Respirology, Melbourne, VIC (2008) [E3]
DOI10.1111/j.1440-1843.2008.01252.x
Co-authorsPhilip Hansbro, Paul Foster
2008Horvat JC, Beagley KW, Gibson PG, Foster PS, Hansbro PM, 'Neutrophil influx during chlamydial lung infection determines the phenotype of allergic airways disease', Respirology, Melbourne, VIC (2008) [E3]
DOI10.1111/j.1440-1843.2008.01252.x
Co-authorsPaul Foster, Jay Horvat, Philip Hansbro
2008Essilfie A-T, Preston JA, Horvat JC, Dunkley ML, Foster PS, Gibson PG, et al., 'Haemophilus influenzae (Hi) infection in asthma may drive the development of neutrophilic asthma (NA)', Respirology, Melbourne, VIC (2008) [E3]
DOI10.1111/j.1440-1843.2008.01252.x
Co-authorsJay Horvat, Paul Foster, Philip Hansbro, Margaret Dunkley, Jodie Simpson
2008Simpson JL, Hansbro PM, McDonald VM, Gibson PG, 'Age and disease related changes in airway inflammation in older people with COPD', Respirology, Melbourne, VIC (2008) [E3]
DOI10.1111/j.1440-1843.2008.01252.x
Co-authorsPhilip Hansbro, Jodie Simpson, Vanessa Mcdonald
2008Powell H, Gibson PG, 'The efficacy of using LABA/ICS combination therapy as part of a written asthma action plan', Respirology, Melbourne, VIC (2008) [E3]
DOI10.1111/j.1440-1843.2008.01252.x
2008Marchant JM, Gibson PG, Grissell TV, Masters IB, Chang AB, 'Paediatric chronic cough: The role of protracted bronchitis', Respirology, Melbourne, VIC (2008) [E3]
2008McDonald VM, Higgins IJ, Gibson PG, 'The use of qualitative interviews to gain insight into older people with COPD and asthma', Respirology, Melbourne, VIC (2008) [E3]
DOI10.1111/j.1440-1843.2008.01251.x
Co-authorsIsabel Higgins, Vanessa Mcdonald
2008McDonald VM, Simpson JL, Higgins IJ, Gibson PG, 'A problem based assessment of asthma and COPD in an older population', Respirology, Melbourne, VIC (2008) [E3]
DOI10.1111/j.1440-1843.2008.01252.x
Co-authorsJodie Simpson, Vanessa Mcdonald, Isabel Higgins
2008Leadbeater KE, Daugherty BR, Gibson PG, 'Treatment of gastro-oesophageal reflux does not improve asthma outcomes: A systematic review', Respirology, Melbourne, VIC (2008) [E3]
DOI10.1111/j.1440-1843.2008.01252.x
2008Wood LG, Garg ML, Smith AJ, Smart JM, Gibson PG, 'A high fat challenge activates the innate immune response in asthma', Asia Pacific Journal of Clinical Nutrition, Adelaide, SA (2008) [E3]
Co-authorsLisa Wood, Manohar Garg
2008Wood LG, Attia JR, McElduff P, McEvoy MA, Flood V, Gibson PG, 'Dietary fat and an activated innate immune response are associated with reduced FEV1', Asia Pacific Journal of Clinical Nutrition, Adelaide, SA (2008) [E3]
Co-authorsLisa Wood, John Attia
2008Scott HA, Gibson PG, Garg ML, Smart JM, Wood LG, 'Obesity is associated with increased inflammation in asthma', Asia Pacific Journal of Clinical Nutrition, Adelaide, SA (2008) [E3]
Co-authorsLisa Wood, Manohar Garg, Hayley Scott
2008Jackson B, Powell H, Wood LG, Gibson PG, 'A comparison of two real-time nitric oxide analysers', Asia Pacific Journal of Clinical Nutrition, Adelaide, SA (2008) [E3]
Co-authorsLisa Wood
2008Hansbro PM, Essilfie A-T, Simpson JL, Dunkley ML, Gibson PG, Foster PS, 'Haemophilus influenzae (HI) infection induces features of neutrophilic asthma', Australasian Society for Immunology 38th Annual Scientific Meeting: Delegate Book, Canberra, ACT (2008) [E3]
Co-authorsPaul Foster, Jodie Simpson, Philip Hansbro, Margaret Dunkley
2008Starkey MR, Horvat JC, Kim RY, Phipps S, Gibson PG, Beagley KW, et al., 'Early life chlamydial lung infection enhances allergic airways disease through age-dependent differences in immunopathology', Australasian Society for Immunology 38th Annual Scientific Meeting: Delegate Book, Canberra, ACT (2008) [E3]
Co-authorsMalcolm Starkey, Philip Hansbro, Paul Foster, Jay Horvat
2008Thorburn AN, O'Sullivan BJ, Thomas R, Foster PS, Gibson PG, Hansbro PM, 'Suppression of allergic airways disease by the Streptococcus pneumoniae vaccine prevenar through the induction of regulatory T cells', Australasian Society for Immunology 38th Annual Scientific Meeting: Delegate Book, Canberra, ACT (2008) [E3]
Co-authorsPhilip Hansbro, Paul Foster
2008McLaughlin K, Murphy VE, McCaffery K, Powell H, Clifton V, Giles W, et al., 'The relationship between patient perceived risk of inhaled corticosteroids in pregnancy and medication adherence', Australian Asthma Conference 2008: Conference Program & Abstract Book, Sydney, NSW (2008) [E3]
Co-authorsVanessa Murphy
2007Horvat JC, Preston JA, Gibson PG, Beagley KW, Foster PS, Hansbro PM, 'Development of allergic airways disease (AAD) is differentially affected by the timing of chlamydial infection relative to allergic sensitization', American Journal of Respiratory and Critical Care Medicine, San Francisco, Calif. (2007) [E3]
Co-authorsJay Horvat, Paul Foster, Philip Hansbro
2007Horvat JC, Garside CG, Wade MA, Preston JA, Hansbro NG, Gibson PG, et al., 'Development of allergic airways disease is differentially affected by chlamydial respiratory infection at different ages', American Journal of Respiratory and Critical Care Medicine, San Francisco, Calif. (2007) [E3]
Co-authorsPhilip Hansbro, Paul Foster, Jay Horvat, Nicole Hansbro
2007Baines KJ, Bowden NA, Scott R, Simpson JL, Gibson PG, 'Molecular analysis of neutrophils in asthma subtypes', Respirology (TSANZ Abstracts-Posters), Auckland (2007) [E3]
DOI10.1111/j.1440-1843.2007.001050.x
Co-authorsRodney Scott, Jodie Simpson, Katherine Baines, Nikola Bowden
2007Collins CE, McDonald VM, Whitehead BF, Gibson PG, 'John Hunter Cystic Fibrosis Cohort 1993-2005', 7th Australasian Cystic Fibrosis Conference. Book of Abstracts, Sydney, N.S.W. (2007) [E3]
Co-authorsVanessa Mcdonald, Clare Collins
2007Wark PA, See HV, Oldham R, Timmins N, Gibson PG, Hansbro PM, 'Response by peripheral blood monocytes (PBMCs) to rhinovirus (RV) is greater in cells exposed to infected epithelium in coculture than exposed to RV alone', American Journal of Respiratory and Critical Care Medicine (American Thoracic Society 2007 International Conference Abstracts), San Francisco (2007) [E3]
Co-authorsPeter Wark, Philip Hansbro
2007Wark PA, Grissell TV, Davies B, Mimica J, Oldham R, Shafren DR, Gibson PG, 'Bronchial epithelial cell (BEC) response to clinical rhinovirus (clin-RV) isolates from ASTHMATICS compared to laboratory (lab-RV) strains', American Journal of Respiratory and Critical Care Medicine (American Thoracic Society 2007 International Conference Abstracts), San Francisco (2007) [E3]
Co-authorsPeter Wark
2007Saedi Some Olia A, Garg ML, Wood LG, Wark PA, Gibson PG, 'Lycopene enrichment of cultured epithelial airway cells', Asia Pacific Journal of Clinical Nutrition, Auckland, New Zealand (2007) [E3]
Co-authorsManohar Garg, Peter Wark, Lisa Wood
2007McDonald VM, Simpson JL, Higgins IJ, Gibson PG, 'A problem based assessment of obstructive airways disease (OAD) in an elderly population', European Respiratory Society Annual Congress 2007. Abstracts, Stockholm (2007) [E3]
Co-authorsJodie Simpson, Isabel Higgins, Vanessa Mcdonald
2007Essiflie A, Preston JA, Horvat JC, Dunkley ML, Foster PS, Gibson PG, et al., 'Elucidating the association between Haemophilus influenzae infection and neutrophilic allergic airways disease using mouse models', Immuno 2007: 13th International Congress of Immunology. Abstracts and Posters, Rio de Janeiro, Brazil (2007) [E3]
Co-authorsJodie Simpson, Philip Hansbro, Margaret Dunkley, Jay Horvat, Paul Foster
2007Saedi Some Olia A, Garg ML, Wood LG, Gibson PG, Wark PA, 'Anti-inflammatory effect of lycopene enrichment on infected cultured airway epithelial cells', Respirology (Abstracts of the 12th Congress of the Asian Pacific Society of Respirology), Gold Coast, QLD (2007) [E3]
Co-authorsManohar Garg, Peter Wark, Lisa Wood
2007Gibson PG, 'The overlap syndrome of asthma and COPD in older people: What are its features and how important is it?', Respirology (Abstracts of the 12th Congress of the Asian Pacific Society of Respirology), Gold Coast, Qld (2007) [E3]
2007Powell H, Smart J, Wood LG, Gibson PG, 'Validity of the common cold questionnaire V(CCQ) in asthma exacerbations', Respirology (TSANZ Abstracts-Posters), Auckland (2007) [E3]
CitationsScopus - 10Web of Science - 7
Co-authorsMichael Hensley, Lisa Wood
2007Horvat JC, Moller CG, Wade MA, Preston JA, Hansbro NG, Gibson PG, et al., 'Allergic airways disease (AAD) is differentially affected by chlamydial lung infection at different stages of life', Respirology (TSANZ Abstracts-Posters), Auckland (2007) [E3]
DOI10.1111/j.1440-1843.2007.001050.x
Co-authorsPaul Foster, Nicole Hansbro, Philip Hansbro, Jay Horvat
2007Horvat JC, Preston JA, Gibson PG, Beagley KW, Foster PS, Hansbro PM, 'Timing of chlamydial infection relative to allergen exposure differentially affects allergic airways disease', Respirology (TSANZ Abstracts-Posters), Auckland (2007) [E3]
Co-authorsPaul Foster, Philip Hansbro, Jay Horvat
2007Murphy VE, Clifton VL, Gibson PG, 'Fractional exhaled nitric oxide (FENO) in pregnant women with and without asthma', Respirology (TSANZ Abstracts-Posters), Auckland (2007) [E3]
Co-authorsVicki Clifton, Vanessa Murphy
2007Nguyen T, Hensley MJ, Whitehead BF, Gibson PG, 'Asthma in children: Influence of passive smoking on airway inflammation', Respirology (TSANZ Abstracts-Posters), Auckland (2007) [E3]
Co-authorsMichael Hensley
2007Powell H, Ryan N, Taramarcaz P, Gibson PG, 'Development and validation of a vocal cord dysfunction questionnaire', Respirology (TSANZ Abstracts-Posters), Auckland (2007) [E3]
2007Ryan N, Gibson PG, 'Paradoxical vocal cord movement in chronic cough', Respirology (TSANZ Abstracts-Posters), Auckland (2007) [E3]
2007See H, Oldham R, Timmins N, Hansbro PM, Wark PA, Gibson PG, 'Rhinovirus (RV) induced inflammatory response in mononuclear cells is enhanced by coculture with airway epithelium', Respirology (TSANZ Abstracts-Posters), Auckland (2007) [E3]
DOI10.1111/j.1440-1843.2007.001050.x
Co-authorsPeter Wark, Philip Hansbro
2007Wark PA, Mimica J, Oldham R, Davies DE, Holgate SE, Johnston S, Gibson PG, 'Interferon-G induced protein (IP)- 10 is a novel clinical biomarker of rhinovirus (RV)-induced asthma exacerbations', Respirology (TSANZ Abstracts-Posters), Auckland (2007) [E3]
Co-authorsPeter Wark
2007Wood LG, Garg ML, Powell H, Gibson PG, 'Dietary lycopene reduces neutrophilic airway inflammation in asthma', Respirology (TSANZ Abstracts-Posters), Auckland (2007) [E3]
Co-authorsManohar Garg, Lisa Wood
2007Simpson JL, Hansbro PM, Kenyon ME, Gibson PG, 'Remodelled asthma in the elderly: is asthma turning into COPD?', Respirology (TSANZ Abstracts-Posters), Auckland (2007) [E3]
Co-authorsJodie Simpson, Philip Hansbro
2007Simpson JL, Milne DG, Gibson PG, 'Radiographic differences between neutrophilic asthma, COPD and smokers using HRCT', Respirology (TSANZ Abstracts-Posters), Auckland (2007) [E3]
Co-authorsJodie Simpson
2007Simpson JL, Powell H, Boyle MJ, Scott R, Gibson PG, 'Anti-inflammatory effects of clarithromycin in refractory non-eosinophilic asthma', Respirology (TSANZ Abstracts-Posters), Auckland (2007) [E3]
DOI10.1111/j.1440-1843.2007.001050.x
Co-authorsJodie Simpson, Rodney Scott
2007Timmins NL, Wood LG, Simpson JL, Gibson PG, 'Optimising exhaled breath condensate collection', Respirology (TSANZ Abstracts-Posters), Auckland (2007) [E3]
Co-authorsJodie Simpson, Lisa Wood
2007Jenkins CR, Marks GB, Gibson PG, Wark PA, Thien FCK, Belousova EG, et al., 'A randomised controlled trial of two algorithms for maintaining asthma control on long acting bronchodilators (LABA) and inhaled corticosteroids (ICS)', Respirology (TSANZ Abstracts-Posters), Auckland (2007) [E3]
Co-authorsPeter Wark
2006Horvat JC, Preston JA, Gibson PG, Beagley KW, Foster PS, Hansbro PM, 'Exacerbation of Allergic Airways Disease (AAD) by Chlamydia is Differentially Affected by the Timing of Infection Relative to Allergen Exposure', Immunology and Cell Biology, Auckland, NZ (2006) [E3]
Co-authorsPhilip Hansbro, Paul Foster, Jay Horvat
2006Preston JA, Horvat JC, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'Streptococcus pneumoniae (SPN) lung infection suppresses hallmark features of a mouse model of asthma', Immunology and Cell Biology, Auckland, NZ (2006) [E3]
Co-authorsPhilip Hansbro, Jay Horvat, Paul Foster
2006Horvat JC, Moller CG, Wade MA, Preston JA, Hansbro NG, Gibson PG, et al., 'The development of allergic airways disease (AAD) is differently affected by chlamydial lung infection at different stages of life', Immunology and Cell Biology, Auckland, NZ (2006) [E3]
Co-authorsPhilip Hansbro, Nicole Hansbro, Jay Horvat, Paul Foster
2006Wood LG, Garg ML, Gibson PG, 'Asthma control deteriorates on a low antioxidant diet', European Respiratory Journal Supplement, Munich, Germany (2006) [E3]
Co-authorsManohar Garg, Lisa Wood
2006Wood LG, Garg ML, Powell HG, Gibson PG, 'Dietary lycopene and asthma control: A randomized control trial', Asia Pacific Journal of Clinical Nutrition, Sydney (2006) [E3]
Co-authorsLisa Wood, Manohar Garg
2006Saedisomeolia A, Garg ML, Wood LG, Gibson PG, 'Lycopene supplementation does not influence cytokine profile in asthma patients', Asia Pacific Journal of Clinical Nutrition, Sydney, New South Wales (2006) [E3]
Co-authorsManohar Garg, Lisa Wood
2006Simpson JL, Scott R, Boyle MJ, Oldham RA, Gibson PG, 'IL-8 levels ininflammatory subtypes of airway disease', Respirology, Canberra (2006) [E3]
Co-authorsJodie Simpson, Rodney Scott
2006Grissell TV, Davies B, Mimica JL, Shafren DR, Gibson PG, Wark PA, 'Bronchial epithelial cell response to clinical rhinoviruses isolated from asthmatics compared to laboratory rhinovirus strains', Respirology, Canberra (2006) [E3]
Co-authorsPeter Wark
2006Mattes J, Simpson JL, Foster PS, Gibson PG, 'Trail is upregulated in the airways of asthmatics', Respirology, Canberra (2006) [E3]
Co-authorsPaul Foster, Joerg Mattes, Jodie Simpson
2006Wark PA, Wood LG, Grissell TV, Davies B, Shafren DR, Powell HG, et al., 'Acute virus-induced asthma is characterised by increased expression of toll-like receptors (TLR)-2', Respirology, Canberra (2006) [E3]
Co-authorsLisa Wood, Michael Hensley, Peter Wark
2006Marchant JM, Gibson PG, Timmins NL, Taylor SM, Masters IB, Chang AB, 'Protracted Bacterial Bronchitis in Children - a celluar and inflammatory profile', Respirology, Canberra (2006) [E3]
2006Horvat JC, Wade MA, Preston JA, Hansbro NG, Gibson PG, Beagley KW, et al., 'Early life chlamydial lung infection enhances allergic airways disease (AAD)', Respirology, Canberra (2006) [E3]
Co-authorsNicole Hansbro, Philip Hansbro, Paul Foster, Jay Horvat
2006Preston JA, Horvat JC, Wade MA, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'Inhibition of allergic lung disease by respiratory streptococcus pneumoniae infection', Respirology, Canberra (2006) [E3]
Co-authorsPaul Foster, Philip Hansbro, Jay Horvat
2006Aggarwal S, Grissell TV, Timmins N, Gibson PG, Thompson P, Misso N, '5-Lipoxygenase pathway MRNA expression in sputum cells of patients with Eosinophilic or Non-Eosinophilic Asthma', Respirology, Canberra (2006) [E3]
2006Simpson JL, Scott R, Boyle MJ, Gibson PG, 'Inflammatory subtypes in asthma with fixed airflow obstruction', Respirology, Canberra (2006) [E3]
Co-authorsJodie Simpson, Rodney Scott
2006Baines KJ, Simpson JL, Scott R, Bell NV, Boyle MJ, Gibson PG, 'Enhanced IL-8 release from neutrophils in non-eosinophilic asthma', Respirology, Canberra (2006) [E3]
Co-authorsKatherine Baines, Jodie Simpson, Rodney Scott
2006Wood LG, Garg ML, Gibson PG, 'A low antioxidant diet worsens asthma control', Respirology, Canberra (2006) [E3]
Co-authorsManohar Garg, Lisa Wood
2006Vincent S, Jenkins C, Gibson PG, Helen R, 'Efficacy of B2- Agonist in asthma exacerbations', Respirology, Canberra (2006) [E3]
2006Wlodarczyk JH, Gibson PG, Caeser M, 'Quantitative review: Inhaled corticosteroids and cortisol suppression in airways disease', Respirology, Canberra (2006) [E3]
2006Heather P, Gibson PG, 'Efficacy and safety of long-acting beta-agonist and inhaled corticosteroid therapy for adults with asthma: a meta -view', Respirology, Canberra (2006) [E3]
2006Ryan (Ext) NM, Gibson PG, 'Cough reflex hypersensitivity and upper airway hyperresponsiveness in vocal cord dysfunction with chronic cough', Respirology, Canberra (2006) [E3]
2006Vertigan (Ext) A, Theodoros D, Gibson PG, Winkworth A, 'Efficacy of speech pathology treatment for refractory chronic cough', Respirology, Canberra (2006) [E3]
2006Wood LG, Garg ML, Powell H, Gibson PG, 'Modifying Dietary Antioxidant Consumption Affects Clinical Status and Noneosinophilic Airway Inflammation in Asthma', Respirology, Japan (2006) [E3]
Co-authorsManohar Garg, Lisa Wood
2006Simpson JL, Grissell TV, Douwes J, Scott R, Boyle MJ, Gibson PG, 'Innate immune activation in neutrophilic asthma', The Journal of the Japanese Respiratory Society, Tokyo (2006) [E3]
Co-authorsJodie Simpson, Rodney Scott
2006Horvat JC, Wade MA, Preston JA, Hansbro NG, Gibson PG, Beagley KW, et al., 'Neonatal chlamydial infection exacerbates allergic airways disease', Abstracts ATS 2006 International Conference, San Diego, California (2006) [E3]
Co-authorsPhilip Hansbro, Nicole Hansbro, Paul Foster, Jay Horvat
2006Preston JA, Horvat JC, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'Respiratory Streptococcus pneumoniae infection decreases key inflammatory responses in a mouse model of asthma', Abstracts ATS 2006 International Conference, San Diego, California (2006) [E3]
Co-authorsPhilip Hansbro, Paul Foster, Jay Horvat
2006Simpson JL, Scott R, Boyle MJ, Gibson PG, 'Inflammatory subtypes in Asthma with fixed airflow obstruction', American Thoracic Society. Proceedings, San Diego, California (2006) [E3]
Co-authorsRodney Scott, Jodie Simpson
2006Gadil E, Morris PS, Beissbarth J, Chang A, Gibson PG, Hare K, et al., 'Use of ototopical antibiotic treatment on chronic suppurative otitis media: A randomized placebo controlled trial and feasibility study', 5th International Symposim on Pneumoccoci and Pneumococcal Diseases, Alice Springs (2006) [E3]
Co-authorsPhilip Hansbro
2006Preston JA, Horvat JC, Wade MA, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'Inhibition of allergic lung disease by respiratory Streptococcus pneumoniae infection', 5th International Symposium on Pneumococci and Pneumococcal Diseases, Alice Springs (2006) [E3]
Co-authorsPaul Foster, Jay Horvat, Philip Hansbro
2006Preston JA, Horvat JC, Wade MA, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'The influence of allergic airways disease on the immune response to respiratory Streptococcus pneumoniae infection', 5th International Symposium on Pneumococci and Pneumococcal Diseases, Alice Springs (2006) [E3]
Co-authorsJay Horvat, Philip Hansbro, Paul Foster
2005Murphy VE, Clifton VL, Talbot PI, Gibson PG, 'Severe asthma exacerbations during pregnancy', Perinatal Society of Australia and New Zealand 9th Annual Congress, Adelaide, 13-16 March, 2005, Adelaide (2005) [E3]
CitationsWeb of Science - 83
Co-authorsVanessa Murphy, Vicki Clifton
2005Preston JA, Horvat JC, Wade MA, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'Respiratory streptococcus pneumoniae infection decreases key inflammatory responses in a mouse model of asthma', TISSUE ANTIGENS, Melbourne, AUSTRALIA (2005)
Author URL
Co-authorsPaul Foster, Jay Horvat, Philip Hansbro
2005Horvat JC, Wade MA, Preston JA, Newcombe N, Ferguson AL, Kaiko G, et al., 'Neonatal But Not Adult Chlamydial Infection Induces the Development of Allergic Airways Disease Through Novel Mechanisms Involving Inflammation of Mixed Phenotype', Tissue Antigens, Melbourne, Australia (2005) [E3]
CitationsWeb of Science - 1
Co-authorsPhilip Hansbro, Paul Foster, Jay Horvat
2005Murphy VE, Clifton VL, Gibson PG, 'Asthma exacerbations during pregnancy are associated with low birth weight', European Respiratory Journal, Switzerland (2005) [C3]
Co-authorsVicki Clifton, Vanessa Murphy
2005Wood LG, Garg ML, Blake RJ, Simpson JL, Gibson PG, 'Systemic and airway levels of glutathione and alpha-tocopherol in asthma', Asia Pacific Journal of Clinical Nutrition, Australia (2005) [E3]
Co-authorsLisa Wood, Jodie Simpson, Manohar Garg
2005Horvat JC, Preston JA, Hansbro NG, Ferguson AL, Gibson PG, Beagley KW, et al., 'Neonatal chlamydial infection inhibits the development of allergic airway inflammation in adult mice', Inflammation Research, Melbourne, Australia (2005) [E3]
Co-authorsJay Horvat, Paul Foster, Philip Hansbro, Nicole Hansbro
2005Murphy VE, Talbot PI, Clifton VL, Gibson PG, 'Severe asthma exacerbations during pregnancy', American Journal of Respiratory and Critical Care, New York (2005) [C3]
Co-authorsVanessa Murphy, Vicki Clifton
2005Murphy VE, Clifton VL, Talbot PI, Gibson PG, 'Self-management education for pregnant women with asthma', American Journal of Respiratory and Critical Care Medicine, New York (2005) [C3]
Co-authorsVanessa Murphy, Vicki Clifton
2005Gibson PG, Giles WB, Zakar T, Smith R, Kessell CG, Clifton VL, Murphy VE, 'Inflammatory factors have sex-specified effects on fetal growth in humans', Ceska Gynekologie, Czech Republic (2005) [C3]
Co-authorsVicki Clifton, Vanessa Murphy, Roger Smith
2005Preston JA, Horvat JC, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'Timing of Streptococcus Pneumoniae (pnc) infection determines the magnitute of the effect on allergic airways inflammation (AAI) in a mouse model of asthma', Respirology, Perth Convention Exhibition Centre (2005) [E3]
Co-authorsPhilip Hansbro, Paul Foster, Jay Horvat
2005Preston JA, Horvat JC, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'Respiratory Streptococcus Pneumoniae Infection Decreases Eosinophilia and Mucus Cell Hyperplasia in a Mouse Model of Asthma', Respirology, Perth Convention Exhibition Centre (2005) [E3]
Co-authorsPaul Foster, Philip Hansbro, Jay Horvat
2005Murphy VE, Talbot PI, Clifton VL, Gibson PG, 'Severe asthma exacerbations during pregnancy', Respirology, Philadelphia (2005) [C3]
DOI10.1097/01.AOG.0000185281.21716.02
Co-authorsVanessa Murphy, Vicki Clifton
2005Murphy VE, Clifton VL, Talbot PI, Gibson PG, 'Self-management education for pregnant women with asthma. Thoracic Society of Australia and New Zealand Annual Scientific Meeting, Perth, 18-23 March, 2005', Respirology, - (2005) [C3]
Co-authorsVanessa Murphy, Vicki Clifton
2005Murphy VE, Talbot PI, Gibson PG, 'The prevalence and cycle to cycle variability of premenstrual asthma', Respirology, Hoboken (2005) [C1]
DOI10.1111/j.1440-1843.2005.00663.x-i1
Co-authorsVanessa Murphy
2005Clifton VL, Murphy VE, Gibson PG, Smith R, Giles WB, Scott N, 'Gender specific differences in response to changes in glucocorticoid concentration in the human fetus: Relationship to birthweight', PEDIATRIC RESEARCH, Toronto, CANADA (2005)
Author URL
Co-authorsRoger Smith, Vanessa Murphy
2004Clifton VL, Murphy VE, Osei-Kumah A, Giles WB, Smith R, Gibson PG, 'Gender specific mechanisms of human fetal cortisol metabolism and immunity.', JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION, Houston, TX (2004)
Author URL
Co-authorsRoger Smith, Vanessa Murphy
2004Gibson PG, Murphy VE, Kessell CG, Talbot PI, Giles WB, Smith R, Clifton VL, 'Effect of fetal gender on maternal athsma during pregnancy', American Journal of Respiratory Care, Not Known (2004) [C3]
Co-authorsVicki Clifton, Vanessa Murphy, Roger Smith
2004Talbot PI, Murphy VE, Kessell CG, Giles WB, Smith R, Gibson PG, Clifton VL, 'Effect of fetal gender on maternal asthma during pregnancy', Respirology, Australia (2004) [C3]
Co-authorsVicki Clifton, Vanessa Murphy, Roger Smith
2004Murphy VE, Kessell CG, Talbot PI, Gibson PG, Clifton VL, 'Asthma education, lung function and inflammation in pregnant women: relation to birth weight', 8th Annual Conference of the Perinatal Society of Australia and New Zealand, Sydney, 15-19 March, 2004, Sydney (2004) [E3]
Co-authorsVanessa Murphy, Vicki Clifton
2004Clifton VL, Murphy VE, Gibson PG, 'Gender specific growth mechanisms in the human fetus', 8th Annual Conference of the Perinatal Society of Australia and New Zealand, Sydney, 15-19 March, 2004, Sydney (2004) [E3]
Co-authorsVanessa Murphy, Vicki Clifton
2004Wood LG, Garg ML, Blake RJ, Gibson PG, 'Carotenoid concentrations in asthmatics versus healthy controls', Asia Pacific Journal of Clinical Nutrition, Brisbane (2004) [E3]
Co-authorsManohar Garg
2004Murphy VE, Gibson PG, Kessell CG, Clifton VL, 'Asthma self-management education for pregnant women delivered in an antenatal clinic setting', Perinatal Scoiety of Australian and New Zealand 9th annual Congress, Adelaide, 13-16 March, Adealide (2004) [E3]
Co-authorsVicki Clifton, Vanessa Murphy
2003Murphy VE, Gibson PG, Giles WB, Smith R, Clifton VL, 'A novel model for examining fetal growth restriction in human pregnancy', Reproductive Sciences, United States (2003) [C3]
Co-authorsVicki Clifton, Roger Smith, Vanessa Murphy
2003Murphy VE, Johnson RF, Wang Y, Akinsanya K, Gibson PG, Smith R, Clifton VL, 'A proteomic analysis of maternal plasma, umbilical cord plasma and placenta in asthmatic and non-asthmatic pregnancies', Australian Society for Medical Research, National Scientific Conference, Glenelg, 22-24 Nov, 2003, Not Known (2003) [E3]
Co-authorsRoger Smith, Vicki Clifton, Vanessa Murphy
2003Murphy VE, Gibson PG, Giles WB, Smith R, Clifton VL, 'The effect of fetal gender on maternal inflammation and lung function in asthmatic pregnancies', Endocrine Society of Australia Annual Meeting, Melbourne 14-17 Sept, 2003, Melbourne (2003) [E3]
Co-authorsVanessa Murphy, Roger Smith, Vicki Clifton
2003Gibson PG, 'Evidence-based medicine at the bedside', PROCEEDINGS OF THE 8TH CONGRESS OF THE ASIAN PACIFIC SOCIETY OF RESPIROLOGY, Kuala Lumpur, MALAYSIA (2003)
Author URL
2003Murphy VE, Gibson PG, Giles WB, Smith R, Zarzycki PK, 'Placental and maternal inflammatory pathways in pregnancies complicated by asthma', Placenta, United Kingdom (2003) [C3]
Co-authorsRoger Smith, Vanessa Murphy
2002Murphy VE, Gibson PG, Giles WB, Zakar T, Smith R, Kessell CG, Clifton VL, 'Sex-specific changes in placental function and fetal growth and development in pregnancies complicated by ashtma', Endocrine Society of Australia Annual Scientific Meeting, Adelaide, 22-25 Sept, 2002, Adelaide (2002) [E3]
Co-authorsVicki Clifton, Vanessa Murphy, Roger Smith
2001McDonald VM, Cookson K, Dymond L, Kesseil C, Pratt P, Gibson PG, 'Inhaler polvpharmacy use among patients with asthma', Respirology (2001)

Many patients with asthma use two or more drag classes. Poor inhalation technique limits drag efficacy. There has been an increase in the number and type of drug delivery systems available. This may accentuate the problems with poor inhalation technique and negate the advantage of drag delivery by inhalation. AIMS: The aims of this study are to describe the number of different devices used by patients with asthma, the adequacy of inhalation technique for each device and the effect of a structured education programme on technique and device selection. DESIGN: A cross sectional analytic survey. METHODS: Data was collected from patients attending the Asthma Management Service (AMS) between 1/1/00 and 30/9/00. Inhaler technique was assessed by an asthma educator and rated as adequate or inadequate. The number of devices used by each patient was analysed together with their proficiency of use. RESULTS: 123 patients were referred to the AMS and 112 (91%) attended an initial assessment. 54% were female and 25% were smokers. The age range was 17-79 years. 56% were on doses of ICS greater than 800mcgs/day. 74% of patients were using multiple devices. The patients were using an average of 1.9 different inhalation devices. Inadequate inhaler technique was present in 23% of pMDI users, 6% of spacer users, 29% of turbuhaler users, and 0% of Accuhaler users. Of those using multiple devices 26% were rated as inadequate with at least one of their devices. CONCLUSION: Inhaler polypharmacy exists as a unique problem among people with airways disease, and could lead to limited drag efficacy in a significant proportion of patients. There is a role for asthma education in the identification and management of this problem. :.

Co-authorsVanessa Mcdonald
2001Kessell C, McDonald V, Pratt P, Cookson K, Wild K, Clifton V, Gibson PG, 'Evaluation of an asthma education programme delivered in an antenatal clinic', Respirology (2001)

Severe and poorly controlled asthma may lead to adverse outcomes for mothers and their babies. An asthma management and education programme was established in the Antenatal Clinic (ANC) of John Hunter Hospital to optimise asthma management in pregnant women with asthma. Aim: The aim of this study was to evaluate the effect of the Asthma Management Service in the John Hunter Hospital ANC. Design: Longitudinal analytic survey. Method: Women were enrolled in their first trimester and underwent an initial assessment of asthma severity, treatment and management skills. Deficits were corrected by skills education, medical assessment and treatment. Records were reviewed of pregnant women with asthma who attended the Asthma Management Service between January 1998 and December 1999. Results: 83 women were enrolled and 72 patients attended between 2 and 8 visits during pregnancy, depending upon asthma severity. Conclusion: After structured asthma education, there were significant improvements in asthma knowledge and management skills. The antenatal clinic is a opportune setting for asthma education among pregnant women with asthma. Asthma Control Visit 1 After Education p Value Night Symptoms 53% 42% 0.15 Morning Symptoms 66% 46% 0.01 Activity Limitation 35% 30% 0.65 Asthma Skills pMDI: Inadequate 13% 0% 0.001 Spacer: Inadequate 2% 0% 0.50 Medication Knowledge 47% 88% 0.0001 Action Plan 13% 78% 0.0001 Peak Flow Monitoring 8% 78% 0.0001.

Co-authorsVanessa Mcdonald
2001Murphy VE, Zakar T, Gibson PG, Giles WB, Smith R, Clifton VL, 'Pleacental 11beta-HSD2 activity in asthmatic women', Reproductive sciences, United States (2001) [C3]
Co-authorsRoger Smith, Vanessa Murphy, Vicki Clifton
2001Murphy VE, Zakar T, Smith R, Giles WB, Gibson PG, Clifton VL, 'A potential mechnism for growth retardation in pregnancies complicated by asthma', Endocrine Society of Australia Annual Scientific Meeting, Gold Coast, 9-12 Sept, 2001, Gold Coast (2001) [E3]
Co-authorsRoger Smith, Vanessa Murphy, Vicki Clifton
2001Collins CE, Linabury N, Whitehead BF, Gibson PG, 'Nutritional status & lung function in the adolescent cohort attending John Hunter Hospital CF Clinic', Proceedings of the 4th Australian CF Conference, Brisbane (2001) [E3]
Co-authorsClare Collins
2000Fitzgerald D, Wood LG, Gibson PG, Cooper D, Garg ML, 'Elevated plasma levels of 8-iso-PGF2a in asthma', American Journal of Respiratory and Critical Care Medicine ISSN 1073-449X, Seattle, USA (2000) [E3]
Co-authorsManohar Garg, Lisa Wood
2000Jones PD, Hankin RG, Cai Y, Norzilla M, Henry RL, Gibson PG, Simpson J, 'Tolerability, Safety and Success of Induced Sputum with Hypertonic Saline (HS) and the Combined HS Challenge in Children', Journal of Paediatrics & Child Health, Adelaide (2000) [E3]
2000Jones PD, Hankin RG, Henry RH, Gibson PG, Simpson J, 'How Chemotherapy Alters the Prevalence of Asthma', Journal of Paediatrics & Child Health, Adelaide (2000) [E3]
1999Jones PD, Henry RL, Francis L, Gibson PG, 'Chemotherapy reduces the prevalence of asthma symptoms in children with cancer: Implications for the role of airway inflammation in asthma', JOURNAL OF PAEDIATRICS AND CHILD HEALTH, CHRISTCHURCH, NEW ZEALAND (1999)
DOI10.1046/j.1440-1754.1999.00358.xAuthor URL
CitationsScopus - 1Web of Science - 1
1999Wood LG, Fitzgerald D, Gibson PG, Cooper D, Collins CE, Garg ML, 'Isoprostanes as a Novel Marker of Oxidative Stress in Cystic Fibrosis', 3rd Australian Cystic Fibrosis Conference, Sydney, Australia (1999) [E3]
Co-authorsLisa Wood, Manohar Garg, Clare Collins
1999Wood LG, Fitzgerald D, Gibson PG, Cooper D, Collins CE, Garg ML, '8-ISO-PGF2a and Oxidative Stress in Cystic Fibrosis', Weighing the Evidence Programme and Proceedings, Auckland, New Zealand (1999) [E3]
Co-authorsLisa Wood, Clare Collins, Manohar Garg
1998Gibson PG, 'Use of induced sputum to examine airway inflammation in childhood asthma', JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, HAMILTON, CANADA (1998)
DOI10.1016/S0091-6749(98)70039-9Author URL
CitationsScopus - 29Web of Science - 22
1998Wood LG, Fitzgerald D, Cooper D, Gibson PG, Garg ML, 'Antioxidant defenses in cystic fibrosis patients', Proceedings of the Nutrition Society of Australia, Adelaide, South Australia (1998) [E3]
Co-authorsManohar Garg, Lisa Wood
Show 280 more conferences

Software (2 outputs)

YearCitationAltmetricsLink
1998Davies HM, Olson LG, Gibson PG, 'Methotrexate as a steroid- sparing agent in adults with asthma', NOT AVAILABLE, Update Software, Oxford (1998) [G1]
1998Gibson PG, Wilson AJ, Coughlan J, Hensley MJ, Abramson MJ, Bauman A, Walters EH, 'The effects of limited (information only) asthma education on health outcomes of adults with asthma.(In: Cates C, DuCharme F, Gibson P, Jones P, Rowe B, Wolf F, Airays Module Cochrane Database of Systematic Reviews', NOT AVAILABLE, Update Software, Oxford U.K. (1998) [G1]
Co-authorsMichael Hensley

Patent (3 outputs)

YearCitationAltmetricsLink
2008Hansbro PM, Gibson PG, Vaccine compositions (2008) [I3]
Co-authorsPhilip Hansbro
2007Gibson PG, Hansbro PM, Treatment and prevention of allergic airways diseases (2007) [I3]
Co-authorsPhilip Hansbro
2006Gibson PG, Wood LG, Garg ML, Method for evaluating status of asthma control (2006) [I3]
Co-authorsManohar Garg, Lisa Wood

Creative Work (1 outputs)

YearCitationAltmetricsLink
2011McDonald VM, Wark PA, Gibson PG, Alison J, Spencer L, Wood LG, Roberts M, Living with COPD: Chronic Obstructive Pulmonary Disease, The Australian Lung Foundation, Newcastle (2011) [J2]
Co-authorsVanessa Mcdonald, Lisa Wood, Peter Wark
Edit

Grants and Funding

Summary

Number of grants116
Total funding$26,253,088

Click on a grant title below to expand the full details for that specific grant.


20151 grants / $25,222

Targeting neutrophil extracellular traps as a novel therapeutic option in COPD$25,222

Funding body: John Hunter Hospital Charitable Trust Fund

Funding bodyJohn Hunter Hospital Charitable Trust Fund
Project TeamDoctor Katie Baines, Conjoint Professor Peter Gibson
SchemeResearch Grant
RoleInvestigator
Funding Start2015
Funding Finish2015
GNoG1500570
Type Of FundingOther Public Sector - State
Category2OPS
UONY

201411 grants / $5,239,942

National Clinical Centre of Research Excellence in Severe Asthma$2,542,311

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamConjoint Professor Peter Gibson, Professor Guy Marks, Associate Professor Vanessa McDonald, Conjoint Professor Peter Wark, Conjoint Associate Professor Greg King, Dr Bruce Thompson, Associate Professor Helen Reddel, Professor John Upham, Dr Lorraine Smith, Professor Alan James
SchemeCentres of Research Excellence (CRE) - Centres of Clinical Research Excellence
RoleLead
Funding Start2014
Funding Finish2014
GNoG1400017
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

The Breathing for Life Trial $1,647,904

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamDoctor Vanessa Murphy, Conjoint Professor Peter Gibson, Emeritus Professor Michael Hensley, Professor Joerg Mattes, Professor Warwick Giles, Professor Michael Peek, Associate Professor Andrew Bisits, Associate Professor Leonie Callaway, Dr Kirsten McCaffery, Dr Helen Barrett
SchemeProject Grant
RoleInvestigator
Funding Start2014
Funding Finish2014
GNoG1300106
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Airway Inflammometry for Asthma and COPD: Practitioner Fellowship Peter G Gibson$542,215

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamConjoint Professor Peter Gibson
SchemePractitioner Fellowships
RoleLead
Funding Start2014
Funding Finish2014
GNoG1300083
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Severe Asthma Web-based Database (SAWD) & Research Register$165,000

Funding body: Woolcock Institute of Medical Science

Funding bodyWoolcock Institute of Medical Science
Project TeamConjoint Professor Peter Gibson, Professor Guy Marks
SchemeResearch Grant
RoleLead
Funding Start2014
Funding Finish2014
GNoG1400292
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

Greenland Study$140,000

Funding body: Bispebjerg Hospital

Funding bodyBispebjerg Hospital
Project TeamConjoint Professor Peter Gibson, Doctor Katie Baines, Professor Vibeke Backer
SchemeInternational Collaboration
RoleLead
Funding Start2014
Funding Finish2014
GNoG1400539
Type Of FundingInternational - Non Competitive
Category3IFB
UONY

The Nanostring nCounter System$75,000

Funding body: Ramaciotti Foundations

Funding bodyRamaciotti Foundations
Project TeamProfessor Darryl Knight, Professor Phil Hansbro, Laureate Professor Paul Foster, Professor Rodney Scott, Conjoint Professor Peter Gibson, Professor Michael Nilsson
SchemeMajor Equipment Award
RoleInvestigator
Funding Start2014
Funding Finish2014
GNoG1300853
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

The Nanostring nCounter System$40,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamProfessor Darryl Knight, Professor Phil Hansbro, Laureate Professor Paul Foster, Professor Rodney Scott, Conjoint Professor Peter Gibson, Professor Michael Nilsson
SchemeEquipment Grant
RoleInvestigator
Funding Start2014
Funding Finish2014
GNoG1301083
Type Of FundingOther Public Sector - State
Category2OPS
UONY

Investigating the Phenotypes of Bronchiectasis$27,512

Funding body: John Hunter Hospital Charitable Trust Fund

Funding bodyJohn Hunter Hospital Charitable Trust Fund
Project TeamAssociate Professor Vanessa McDonald, Conjoint Professor Peter Gibson, Mrs Netsanet Negewo
SchemeResearch Grant
RoleInvestigator
Funding Start2014
Funding Finish2014
GNoG1400084
Type Of FundingOther Public Sector - State
Category2OPS
UONY

The Nanostring nCounter System$20,000

Funding body: John Hunter Hospital Charitable Trust Fund

Funding bodyJohn Hunter Hospital Charitable Trust Fund
Project TeamProfessor Darryl Knight, Professor Phil Hansbro, Laureate Professor Paul Foster, Professor Rodney Scott, Conjoint Professor Peter Gibson, Professor Michael Nilsson
SchemeResearch Grant
RoleInvestigator
Funding Start2014
Funding Finish2014
GNoG1301084
Type Of FundingOther Public Sector - State
Category2OPS
UONY

The role of comorbidities and inflammation in Chronic Obstructive Pulmonary Disease (COPD)$20,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamMrs Netsanet Negewo, Associate Professor Vanessa McDonald, Conjoint Professor Peter Gibson, Doctor Katie Baines
SchemePostgraduate Research Scholarship
RoleInvestigator
Funding Start2014
Funding Finish2014
GNoG1401393
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

Predicting who is at risk of worsening lung disease in Cystic Fibrosis$20,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamConjoint Professor Peter Wark, Doctor Katie Baines, Associate Professor Vanessa McDonald, Conjoint Professor Peter Gibson, Associate Professor Scott Bell, Dr David Reid
SchemeProject Grant
RoleInvestigator
Funding Start2014
Funding Finish2014
GNoG1401410
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

201310 grants / $2,396,459

HMRI MRSP Infrastructure (12-16) - VIVA Program$973,342

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamLaureate Professor Paul Foster, Conjoint Professor Peter Gibson
SchemeNSW MRSP Infrastructure Grant
RoleInvestigator
Funding Start2013
Funding Finish2013
GNoG1300567
Type Of FundingOther Public Sector - State
Category2OPS
UONY

Inflammometry in Stable COPD; A Randomised Controlled Trial (RCT)$717,071

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamConjoint Professor Peter Gibson, Associate Professor Vanessa McDonald, Associate Professor Jodie Simpson, Conjoint Professor Peter Wark
SchemeProject Grant
RoleLead
Funding Start2013
Funding Finish2013
GNoG1200185
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Gene Expression Biomarkers Predict Severe Asthma Inflammatory Phenotype, Activation Mechanisms and Treatment Response$449,307

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamDoctor Katie Baines, Conjoint Professor Peter Gibson, Associate Professor Jodie Simpson
SchemeProject Grant
RoleInvestigator
Funding Start2013
Funding Finish2013
GNoG1200188
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Protracted bacterial bronchitis: long term outcomes, systemic and airway predictors of recurrence$76,526

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Anne Chang, Professor John Upham, Conjoint Professor Peter Gibson, Dr Stephanie Yerkovich, Doctor Katie Baines, Dr Sandra Hodge, Mrs Susan Pizzuto, Associate Professor Ian Masters, Dr Helen Buntain
SchemeProject Grant
RoleLead
Funding Start2013
Funding Finish2013
GNoG1200534
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Immunometabolism in Obese Asthmatics$73,959

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamConjoint Professor Peter Gibson, Associate Professor Lisa Wood
SchemeProject Grant
RoleLead
Funding Start2013
Funding Finish2013
GNoG1300196
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

The Financial Markets Foundation for Children$25,627

Funding body: Financial Markets Foundation for Children

Funding bodyFinancial Markets Foundation for Children
Project TeamConjoint Professor Peter Gibson
SchemeProject Grant
RoleLead
Funding Start2013
Funding Finish2013
GNoG1301030
Type Of FundingAust Competitive - Non Commonwealth
Category1NS
UONY

The Financial Markets Foundation for Children$25,627

Funding body: Financial Markets Foundation for Children

Funding bodyFinancial Markets Foundation for Children
Project TeamConjoint Professor Peter Gibson
SchemeProject Grant
RoleLead
Funding Start2013
Funding Finish2013
GNoG1301030
Type Of FundingExternal
CategoryEXTE
UONY

BD FACSCanto II Violet Laser (405nm) upgrade including Trigon and 2 photomultiplier tubes (PMTs)$25,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamConjoint Professor Peter Wark, Doctor Alan Hsu, Doctor Katie Baines, Associate Professor Jodie Simpson, Conjoint Professor Peter Gibson, Ms Hayley See
SchemeEquipment Grant
RoleInvestigator
Funding Start2013
Funding Finish2013
GNoG1201180
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

Inflammometry-based management of asthma in pregnancy for the prevention of preterm birth: the iMAP study$20,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Vanessa Murphy, Conjoint Professor Peter Gibson, Emeritus Professor Michael Hensley, Conjoint Professor Warwick Giles, Conjoint Associate Professor Andrew Bisits, Dr Kirsten McCaffery, Professor Paul Colditz, Professor Michael Peek
SchemeNear Miss Grant
RoleInvestigator
Funding Start2013
Funding Finish2013
GNoG1300477
Type Of FundingInternal
CategoryINTE
UONY

Effect of better asthma management in pregnancy on antiviral responses, atopy and airways inflammation in early childhood$10,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Joerg Mattes, Conjoint Professor Peter Gibson, Doctor Vanessa Murphy
SchemeNear Miss Grant
RoleInvestigator
Funding Start2013
Funding Finish2013
GNoG1300476
Type Of FundingInternal
CategoryINTE
UONY

20129 grants / $1,076,820

HMRI MRSP Infrastructure (11-12)- VIVA$486,671

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamLaureate Professor Paul Foster, Conjoint Professor Peter Gibson
SchemeNSW MRSP Infrastructure Grant
RoleInvestigator
Funding Start2012
Funding Finish2012
GNoG1101137
Type Of FundingOther Public Sector - State
Category2OPS
UONY

BD FACSAria III Cell Sorter: 3 laser 10-colour Flow Cytometer$180,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamLaureate Professor Paul Foster, Conjoint Professor Peter Gibson, Laureate Professor John Aitken, Professor Roger Smith, Professor Rodney Scott
SchemeLinkage Infrastructure Equipment & Facilities (LIEF)
RoleInvestigator
Funding Start2012
Funding Finish2012
GNoG1100746
Type Of FundingScheme excluded from IGS
CategoryEXCL
UONY

BD FACSAria III Cell Sorter: 3 laser 10-colour Flow Cytometer$150,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamLaureate Professor Paul Foster, Professor Trevor Day, Conjoint Professor Peter Gibson, Laureate Professor John Aitken, Professor Roger Smith, Professor Rodney Scott
SchemeEquipment Grant
RoleInvestigator
Funding Start2012
Funding Finish2012
GNoG1100744
Type Of FundingInternal
CategoryINTE
UONY

BD FACSAria III Cell Sorter: 3 laser 10-colour Flow Cytometer$122,927

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamLaureate Professor Paul Foster, Conjoint Professor Peter Gibson, Laureate Professor John Aitken, Professor Roger Smith, Professor Rodney Scott
SchemeProject Grant
RoleInvestigator
Funding Start2012
Funding Finish2012
GNoG1200668
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

Phenotype based management of severe persistent asthma$34,454

Funding body: John Hunter Hospital Charitable Trust Fund

Funding bodyJohn Hunter Hospital Charitable Trust Fund
Project TeamAssociate Professor Vanessa McDonald, Doctor Katie Baines, Conjoint Professor Peter Gibson
SchemeResearch Grant
RoleInvestigator
Funding Start2012
Funding Finish2012
GNoG1200211
Type Of FundingOther Public Sector - State
Category2OPS
UONY

Body plethysmograph respiratory function system$33,076

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamConjoint Professor Peter Gibson, Conjoint Professor Peter Wark, Associate Professor Lisa Wood, Associate Professor Jodie Simpson, Doctor Katie Baines, Doctor Vanessa Murphy, Doctor Jeffrey Pretto, Emeritus Professor Michael Hensley, Ms Jenny Mackney
SchemeEquipment Grant
RoleLead
Funding Start2012
Funding Finish2012
GNoG1100973
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

The Growing into Asthma Study: Wheezing prevalence and markers of airways inflammation in preschoolers born to mothers in asthma exacerbations in pregnancy$25,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamProfessor Joerg Mattes, Conjoint Professor Peter Gibson, Emeritus Professor Michael Hensley, Conjoint Associate Professor Bruce Whitehead, Doctor Vanessa Murphy
SchemeProject Grant
RoleInvestigator
Funding Start2012
Funding Finish2012
GNoG1200662
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Fatty acids, Carbohydrates and Bronchodilator Responses in Asthma$24,692

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamAssociate Professor Lisa Wood, Conjoint Professor Peter Gibson
SchemeProject Grant
RoleInvestigator
Funding Start2012
Funding Finish2012
GNoG1200618
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Phenotype based management of severe persistent asthma$20,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamAssociate Professor Vanessa McDonald, Doctor Katie Baines, Conjoint Professor Peter Gibson
SchemeResearch Grant
RoleInvestigator
Funding Start2012
Funding Finish2012
GNoG1101169
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

20116 grants / $670,884

HMRI MRSP Infrastructure Grant (10-11) VIVA$485,452

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamConjoint Professor Peter Gibson, Laureate Professor Paul Foster
SchemeNSW MRSP Infrastructure Grant
RoleLead
Funding Start2011
Funding Finish2011
GNoG1100162
Type Of FundingOther Public Sector - State
Category2OPS
UONY

DVCR Special Grant 2011$80,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamConjoint Professor Peter Gibson
SchemeSpecial Project Grant
RoleLead
Funding Start2011
Funding Finish2011
GNoG1101010
Type Of FundingInternal
CategoryINTE
UONY

MAID: Microarray analysis following anti inflammatory interventions in COPD$47,732

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamAssociate Professor Lisa Wood, Conjoint Professor Peter Gibson
SchemeCentres of Research Excellence (CRE) - Centres of Clinical Research Excellence
RoleInvestigator
Funding Start2011
Funding Finish2011
GNoG1100019
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Transcriptional Phenotyping of COPD and the relationship between neutrophilic airway inflammation, airway infection and activation of proinflammatory pathways$24,000

Funding body: John Hunter Hospital Charitable Trust Fund

Funding bodyJohn Hunter Hospital Charitable Trust Fund
Project TeamDoctor Katie Baines, Conjoint Professor Peter Gibson, Associate Professor Jodie Simpson
SchemeResearch Grant
RoleInvestigator
Funding Start2011
Funding Finish2011
GNoG1100635
Type Of FundingOther Public Sector - State
Category2OPS
UONY

Identification of a specific biomarker signature that identifies asthma phenotype $23,700

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Katie Baines, Associate Professor Jodie Simpson, Conjoint Professor Peter Gibson
SchemeProject Grant
RoleInvestigator
Funding Start2011
Funding Finish2011
GNoG1001054
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Lung Function (Spirometry) testing and sputum induction equipment - establishing 3 new clinical workstations. Medgraphics CPFS/d USB spirometer with breezesuite software (x3). Laptop computer (x3). Ul$10,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamConjoint Professor Peter Gibson, Associate Professor Jodie Simpson, Associate Professor Lisa Wood, Doctor Katie Baines, Conjoint Professor Peter Wark, Doctor Vanessa Murphy
SchemeEquipment Grant
RoleLead
Funding Start2011
Funding Finish2011
GNoG1100038
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

20103 grants / $751,446

HMRI MRSP Infrastructure Grant (09-10) - VIVA$397,696

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamLaureate Professor Paul Foster, Conjoint Professor Peter Gibson
SchemeNSW MRSP Infrastructure Grant
RoleInvestigator
Funding Start2010
Funding Finish2010
GNoG1000232
Type Of FundingOther Public Sector - State
Category2OPS
UONY

Gabapentin in the treatment of idiopathic chronic cough: a randomised double-blind placebo-controlled trial$319,750

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamConjoint Professor Peter Gibson
SchemeProject Grant
RoleLead
Funding Start2010
Funding Finish2010
GNoG0190193
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Real time PCR machine (Mastercycler ep realplex2 from Epprndorf) $34,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamAssociate Professor Jodie Simpson, Conjoint Professor Peter Gibson, Conjoint Professor Peter Wark, Associate Professor Lisa Wood, Doctor Vanessa Murphy, Doctor Robert Scott, Doctor Katie Baines
SchemeEquipment Grant
RoleInvestigator
Funding Start2010
Funding Finish2010
GNoG1000056
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

200910 grants / $4,065,779

The AMAZES study: asthma and macrolides: the AZithromycin efficacy and safety study$2,991,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamConjoint Professor Peter Gibson, Associate Professor Jodie Simpson, Professor John Upham, Associate Professor Paul Reynolds, Dr Ian Yang, Dr Sandra Hodge
SchemeProject Grant
RoleLead
Funding Start2009
Funding Finish2009
GNoG0188843
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Practitioner Fellowship (re-appointment)$360,625

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamConjoint Professor Peter Gibson
SchemePractitioner Fellowships
RoleLead
Funding Start2009
Funding Finish2009
GNoG0188586
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Epigenetic regulation of airways inflammation in non-eosinophilic asthma$63,354

Funding body: Asthma Foundation of New South Wales

Funding bodyAsthma Foundation of New South Wales
Project TeamConjoint Professor Peter Gibson, Doctor Katie Baines, Associate Professor Jodie Simpson
SchemePhD Scholarships
RoleLead
Funding Start2009
Funding Finish2009
GNoG0189748
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

394591 ELx405UV select plate washer and workstation integration kit$27,500

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamConjoint Professor Peter Gibson, Doctor Xiao Yan He, Associate Professor Jodie Simpson, Associate Professor Lisa Wood, Conjoint Professor Peter Wark
SchemeEquipment Grant
RoleLead
Funding Start2009
Funding Finish2009
GNoG0189853
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

Growing into asthma: A birth cohort study to investigate the prenatal and development origins of asthma$24,800

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Vanessa Murphy, Professor Joerg Mattes, Conjoint Professor Peter Gibson
SchemeProject Grant
RoleInvestigator
Funding Start2009
Funding Finish2009
GNoG0189802
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

The role of Gabapentin in the treatment of refractory chronic dry cough: A randomised double-blind placebo-controlled study$20,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamConjoint Professor Peter Gibson
SchemeResearch Higher Degree Support Grant
RoleLead
Funding Start2009
Funding Finish2009
GNoG0189804
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Integrated problem based management of Obstructive Airways Disease in older people$20,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamConjoint Professor Peter Gibson, Professor Isabel Higgins
SchemeResearch Higher Degree Support Grant
RoleLead
Funding Start2009
Funding Finish2009
GNoG0189807
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Growing into asthma: a birth cohort study to investigate the prenatal and development origins of asthma$13,500

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Vanessa Murphy, Professor Joerg Mattes, Conjoint Professor Peter Gibson
SchemeProject Grant
RoleInvestigator
Funding Start2009
Funding Finish2009
GNoG0190487
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

20087 grants / $318,785

Exploring the link between obesity and asthma$75,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamAssociate Professor Lisa Wood, Conjoint Professor Peter Gibson, Professor Manohar Garg
SchemePost Graduate Support Grant
RoleInvestigator
Funding Start2008
Funding Finish2008
GNoG0188479
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Exploring the link between asthma and obesity$66,771

Funding body: CCRE in Respiratory and Sleep Medicine

Funding bodyCCRE in Respiratory and Sleep Medicine
Project TeamAssociate Professor Lisa Wood, Conjoint Professor Peter Gibson, Professor Manohar Garg, Ms Hayley Scott
SchemePostgraduate Research Scholarship
RoleInvestigator
Funding Start2008
Funding Finish2008
GNoG0188635
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Evaluation of self managed and remote delivery of speech pathology treatment for chronic cough$65,000

Funding body: CCRE in Respiratory and Sleep Medicine

Funding bodyCCRE in Respiratory and Sleep Medicine
Project TeamDoctor Anne Vertigan, Conjoint Professor Peter Gibson
SchemePostdoctoral Research Fellowship
RoleInvestigator
Funding Start2008
Funding Finish2008
GNoG0189582
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

Neurogenic Inflammation and vocal cord dysfunction in chronic cough$42,014

Funding body: CCRE in Respiratory and Sleep Medicine

Funding bodyCCRE in Respiratory and Sleep Medicine
Project TeamConjoint Professor Peter Gibson, Mrs Nicole Ryan
SchemePostgraduate Research Scholarship
RoleLead
Funding Start2008
Funding Finish2008
GNoG0189060
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Becton Dickinson high throughout sampler for the FACSCanto II cytometry system$35,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamConjoint Professor Peter Wark, Conjoint Professor Peter Gibson, Associate Professor Jodie Simpson, Associate Professor Lisa Wood, Doctor Vanessa Murphy, Professor Phil Hansbro
SchemeEquipment Grant
RoleInvestigator
Funding Start2008
Funding Finish2008
GNoG0188547
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

Trans Fatty acids and airway inflammation$25,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamAssociate Professor Lisa Wood, Conjoint Professor Peter Gibson, Professor Manohar Garg
SchemeProject Grant
RoleInvestigator
Funding Start2008
Funding Finish2008
GNoG0188472
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Understanding non-eosinophilic asthma: triggers and treatment$10,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamAssociate Professor Jodie Simpson, Conjoint Professor Peter Gibson
SchemeProject Grant
RoleInvestigator
Funding Start2008
Funding Finish2008
GNoG0188559
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

200711 grants / $2,235,130

Managing asthma in pregnancy: the MAP study$805,875

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamConjoint Professor Peter Gibson, Conjoint Associate Professor Vicki Clifton, Emeritus Professor Michael Hensley, Conjoint Professor Warwick Giles
SchemeProject Grant
RoleLead
Funding Start2007
Funding Finish2007
GNoG0186407
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

HMRI - Viruses, Infection/Immunity, Vaccines and Asthma Research Program$692,213

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamLaureate Professor Paul Foster, Conjoint Professor Peter Gibson, Conjoint Professor Stephen Graves, Associate Professor Darren Shafren
SchemeNSW MRSP Infrastructure Grant
RoleInvestigator
Funding Start2007
Funding Finish2007
GNoG0187930
Type Of FundingOther Public Sector - State
Category2OPS
UONY

Characterisation and Treatment of Innate Immune Dysfunction in Older People with Obstructive Airway Disease$416,875

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamAssociate Professor Jodie Simpson, Conjoint Professor Peter Gibson, Professor Phil Hansbro
SchemeProject Grant
RoleInvestigator
Funding Start2007
Funding Finish2007
GNoG0186426
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

A Problem Based Approach to the Management of Airways Disease in people over the age of 55 years$88,595

Funding body: CCRE in Respiratory and Sleep Medicine

Funding bodyCCRE in Respiratory and Sleep Medicine
Project TeamConjoint Professor Peter Gibson, Professor Isabel Higgins
SchemePostgraduate Research Scholarship
RoleLead
Funding Start2007
Funding Finish2007
GNoG0186902
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Differential regulation of human mast cell degranulation by discrete forms of protein phosphatase 2A$50,000

Funding body: Asthma Foundation of New South Wales

Funding bodyAsthma Foundation of New South Wales
Project TeamProfessor Alistair Sim, Doctor Nikki Verrills, Laureate Professor Paul Foster, Conjoint Professor Peter Wark, Conjoint Professor Peter Gibson, Dr Gregory Kranias
SchemeResearch Grant
RoleInvestigator
Funding Start2007
Funding Finish2007
GNoG0187247
Type Of FundingDonation - Aust Non Government
Category3AFD
UONY

Role of p38 MAPK in regulating sex specific placental glucocorticoid receptor function in pregnancies complicated by asthma$50,000

Funding body: Asthma Foundation of New South Wales

Funding bodyAsthma Foundation of New South Wales
Project TeamConjoint Associate Professor Vicki Clifton, Conjoint Professor Peter Gibson, Conjoint Professor Warwick Giles
SchemeResearch Grant
RoleInvestigator
Funding Start2007
Funding Finish2007
GNoG0187258
Type Of FundingDonation - Aust Non Government
Category3AFD
UONY

Nitric Oxide Monitoring System (NIOX)$45,000

Funding body: NHMRC (National Health & Medical Research Council)

(59) PRC - Priority Research Centre for Asthma & Respiratory Diseases$26,572

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamConjoint Professor Peter Gibson
SchemePublication Performance Grant
RoleLead
Funding Start2007
Funding Finish2007
GNoG0187975
Type Of FundingInternal
CategoryINTE
UONY

The effects of passive smoking on children with Asthma$20,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamConjoint Professor Peter Gibson, Conjoint Associate Professor Bruce Whitehead, Emeritus Professor Michael Hensley
SchemeProject Grant
RoleLead
Funding Start2007
Funding Finish2007
GNoG0187259
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Hewlett Packard 7890 series gas chromatograph with accessories$20,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamAssociate Professor Lisa Wood, Conjoint Professor Peter Wark, Conjoint Professor Peter Gibson, Associate Professor Jodie Simpson, Doctor Vanessa Murphy, Laureate Professor Paul Foster, Professor Phil Hansbro, Conjoint Associate Professor Vicki Clifton, Professor Clare Collins, Conjoint Professor Wayne Smith, Professor John Attia
SchemeEquipment Grant
RoleInvestigator
Funding Start2007
Funding Finish2007
GNoG0188191
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

Class II biohazard containment hood and carbon dioxide cell culture incubator$20,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamConjoint Professor Peter Wark, Conjoint Professor Peter Gibson, Associate Professor Jodie Simpson, Doctor Vanessa Murphy, Associate Professor Lisa Wood, Laureate Professor Paul Foster, Professor Phil Hansbro
SchemeEquipment Grant
RoleInvestigator
Funding Start2007
Funding Finish2007
GNoG0188192
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

20067 grants / $2,105,369

Advanced technology for transcriptomics, genomics and gene mapping$850,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamProfessor Rodney Scott, Professor Ian Dawes, Professor Ronald Trent, Professor Nicholas Hunt, Emeritus Professor Peter Bergquist, Professor Mark Baker, Emeritus Professor Peter Dunkley, Dr Ruby Lin, Conjoint Professor Peter Gibson, Professor Alistair Sim
SchemeLinkage Infrastructure Equipment & Facilities (LIEF)
RoleInvestigator
Funding Start2006
Funding Finish2006
GNoG0185547
Type Of FundingScheme excluded from IGS
CategoryEXCL
UONY

PRC Priority Research Centre for Asthma & Respiratory Diseases$524,282

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamLaureate Professor Paul Foster, Conjoint Professor Peter Gibson, Conjoint Professor Kenneth Beagley, Emeritus Professor Michael Hensley, Professor Phil Hansbro, Professor Joerg Mattes, Professor Alistair Sim, Conjoint Professor Peter Wark
SchemePriority Research Centre
RoleInvestigator
Funding Start2006
Funding Finish2006
GNoG0186914
Type Of FundingInternal
CategoryINTE
UONY

Investigation of the association between chlamydial infection and asthma in different age groups$362,625

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Phil Hansbro, Conjoint Professor Kenneth Beagley, Conjoint Professor Peter Gibson
SchemeProject Grant
RoleInvestigator
Funding Start2006
Funding Finish2006
GNoG0185145
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Surveillance and Analysis of Avian Influenza Viruses in Migratory Birds in Australia$249,625

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Phil Hansbro, Dr Ian Barr, Conjoint Professor Peter Wark, Dr Paul Selleck, Dr Simone Warner, Laureate Professor Paul Foster, Dr Aeron Hurt, Dr Irene Peroulis, Dr John Curran, Conjoint Professor Peter Gibson
SchemePotential Avian Influenza-Induced Pandemic
RoleInvestigator
Funding Start2006
Funding Finish2006
GNoG0186000
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

The relationship between eosinophilic inflammation, viral infection and severe asthma exacerbations during pregnancy$50,000

Funding body: Asthma Foundation of New South Wales

Funding bodyAsthma Foundation of New South Wales
Project TeamDoctor Vanessa Murphy, Conjoint Associate Professor Vicki Clifton, Emeritus Professor Michael Hensley, Conjoint Professor Warwick Giles, Conjoint Professor Peter Gibson
SchemeResearch Grant
RoleInvestigator
Funding Start2006
Funding Finish2006
GNoG0186029
Type Of FundingDonation - Aust Non Government
Category3AFD
UONY

The effect of maternal asthma and its treatment on placental and fetal glucocorticoid receptor expression$50,000

Funding body: Asthma Foundation of New South Wales

Funding bodyAsthma Foundation of New South Wales
Project TeamConjoint Associate Professor Vicki Clifton, Conjoint Professor Peter Gibson, Professor Roger Smith, Conjoint Professor Warwick Giles, Mrs Pip Talbot
SchemeResearch Grant
RoleInvestigator
Funding Start2006
Funding Finish2006
GNoG0186137
Type Of FundingDonation - Aust Non Government
Category3AFD
UONY

Molecular Pathogenesis of Non-Eosinophilic Asthma$18,837

Funding body: Asthma Foundation of New South Wales

Funding bodyAsthma Foundation of New South Wales
Project TeamDoctor Katie Baines, Conjoint Professor Peter Gibson
SchemePhD Scholarships
RoleInvestigator
Funding Start2006
Funding Finish2006
GNoG0185985
Type Of FundingDonation - Aust Non Government
Category3AFD
UONY

20058 grants / $3,991,893

Markers of disease activity$3,002,002

Funding body: CRC for Asthma

Funding bodyCRC for Asthma
Project TeamConjoint Professor Peter Gibson
SchemeResearch Grant
RoleLead
Funding Start2005
Funding Finish2005
GNoG0185871
Type Of FundingCRC - Cooperative Research Centre
Category4CRC
UONY

CCRE for Respiratory and Sleep Medicine$366,110

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Ronald Grunstein, Conjoint Professor Peter Gibson, Emeritus Professor Michael Hensley
SchemeCentres of Research Excellence (CRE) - Centres of Clinical Research Excellence
RoleLead
Funding Start2005
Funding Finish2005
GNoG0185684
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

The role of lycopene supplementation in the management of asthma$328,750

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamConjoint Professor Peter Gibson, Professor Manohar Garg
SchemeProject Grant
RoleLead
Funding Start2005
Funding Finish2005
GNoG0183939
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

2005 RIBG allocation$40,842

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamConjoint Professor Peter Gibson
SchemeResearch Infrastructure Block Grant (RIBG)
RoleLead
Funding Start2005
Funding Finish2005
GNoG0185791
Type Of FundingInternal
CategoryINTE
UONY

HPLC with electrochemical detector$25,000

Funding body: Ramaciotti Foundations

Funding bodyRamaciotti Foundations
Project TeamConjoint Professor Peter Gibson, Associate Professor Lisa Wood
SchemeMajor Equipment Award
RoleLead
Funding Start2005
Funding Finish2005
GNoG0185635
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

Characterisation of non-invasive markers of airway inflammation in pregnancies complicated by asthma$12,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamConjoint Professor Peter Gibson
SchemeProject Grant
RoleLead
Funding Start2005
Funding Finish2005
GNoG0184704
Type Of FundingInternal
CategoryINTE
UONY

Prevention of asthma by immunisation with pneumococcal cell walls$10,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Phil Hansbro, Laureate Professor Paul Foster, Conjoint Professor Kenneth Beagley, Conjoint Professor Peter Gibson
SchemeProject Grant
RoleInvestigator
Funding Start2005
Funding Finish2005
GNoG0184712
Type Of FundingInternal
CategoryINTE
UONY

20049 grants / $1,125,462

Characteristics and mechanisms of persistent asthma after common cold virus infection$400,250

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamConjoint Professor Peter Gibson, Associate Professor Darren Shafren, Emeritus Professor Michael Hensley
SchemeProject Grant
RoleLead
Funding Start2004
Funding Finish2004
GNoG0182884
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Practitioner Fellowship in Asthma Research$319,375

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamConjoint Professor Peter Gibson
SchemePractitioner Fellowships
RoleLead
Funding Start2004
Funding Finish2004
GNoG0183674
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Respiratory Medicine$269,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Vanessa Murphy, Conjoint Professor Peter Gibson
SchemePort Waratah Coal Service Post-Doctoral Fellowship
RoleInvestigator
Funding Start2004
Funding Finish2004
GNoG0184012
Type Of FundingDonation - Aust Non Government
Category3AFD
UONY

Molecular Pathogensis of Non-Eosinphilic Asthma$37,837

Funding body: Asthma Foundation of New South Wales

Funding bodyAsthma Foundation of New South Wales
Project TeamConjoint Professor Peter Gibson, Professor Rodney Scott, Doctor Katie Baines
SchemePhD Scholarships
RoleLead
Funding Start2004
Funding Finish2004
GNoG0183715
Type Of FundingDonation - Aust Non Government
Category3AFD
UONY

Evaluation of a stepwise approach to multi-disciplinary management of chronic cough$25,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Anne Vertigan, Professor Deborah Theodoros, Dr Alison Winkworth, Conjoint Professor Peter Gibson, Dr Colin Reid
SchemeResearch Grant
RoleInvestigator
Funding Start2004
Funding Finish2004
GNoG0184016
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Bio-Rad iCycler iQ Real- Time PCR Detection System (the $25,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamConjoint Professor Peter Gibson
SchemeEquipment Grant
RoleLead
Funding Start2004
Funding Finish2004
GNoG0184299
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

Airway inflammation in childhood asthma$19,000

Funding body: Hunter Children`s Research Foundation

Funding bodyHunter Children`s Research Foundation
Project TeamConjoint Professor Peter Gibson, Conjoint Associate Professor Bruce Whitehead, Emeritus Professor Michael Hensley
SchemeResearch Grant
RoleLead
Funding Start2004
Funding Finish2004
GNoG0184567
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Innate immune activation in chronic obstructive pulmonary disease (COPD)$15,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamConjoint Professor Peter Gibson
SchemeProject Grant
RoleLead
Funding Start2004
Funding Finish2004
GNoG0183373
Type Of FundingInternal
CategoryINTE
UONY

Modulation of immune responses in asthma by bacterial infections during early life.$15,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Phil Hansbro, Laureate Professor Paul Foster, Conjoint Professor Peter Gibson
SchemeProject Grant
RoleInvestigator
Funding Start2004
Funding Finish2004
GNoG0183512
Type Of FundingInternal
CategoryINTE
UONY

20037 grants / $578,650

Non-eosinophilic asthma: mechanisms and treatment$430,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamConjoint Professor Peter Gibson, Conjoint Associate Professor Michael Boyle, Professor Rodney Scott
SchemeProject Grant
RoleLead
Funding Start2003
Funding Finish2003
GNoG0181776
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Modulation of immune responses in the asthmatic lung by bacterial infections.$50,000

Funding body: Asthma Foundation of New South Wales

Funding bodyAsthma Foundation of New South Wales
Project TeamProfessor Phil Hansbro, Conjoint Professor Peter Gibson, Conjoint Professor Kenneth Beagley, Dr Paul Foster
SchemeResearch Grant
RoleInvestigator
Funding Start2003
Funding Finish2003
GNoG0183600
Type Of FundingDonation - Aust Non Government
Category3AFD
UONY

Sievers NOA 280i Nitric Oxide Analyser$36,650

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamConjoint Professor Peter Gibson, Conjoint Associate Professor Vicki Clifton, Conjoint Associate Professor Michael Boyle, Professor Rodney Scott
SchemeEquipment Grant
RoleLead
Funding Start2003
Funding Finish2003
GNoG0183059
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Inflammatory mechanisms in non-eosinophilic ashtma$20,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamConjoint Professor Peter Gibson, Conjoint Associate Professor Michael Boyle
SchemeResearch Grant
RoleLead
Funding Start2003
Funding Finish2003
GNoG0182955
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Treatment of asthma by vaccination with bacterial antigens.$17,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamProfessor Phil Hansbro, Conjoint Professor Peter Gibson, Conjoint Professor Kenneth Beagley
SchemeResearch Grant
RoleInvestigator
Funding Start2003
Funding Finish2003
GNoG0182627
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Carotenoids and flavonoids in asthma$15,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamConjoint Professor Peter Gibson, Professor Manohar Garg, Associate Professor Lisa Wood
SchemeProject Grant
RoleLead
Funding Start2003
Funding Finish2003
GNoG0182435
Type Of FundingInternal
CategoryINTE
UONY

Sparke Helmore Prime Television Corporate Triathlon Award for Research Excellence$10,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamConjoint Professor Peter Gibson
SchemeSparke Helmore/NBN Television Corporate Triathlon Award for Research Excellence
RoleLead
Funding Start2003
Funding Finish2003
GNoG0183641
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

20023 grants / $57,455

Modulation of inflammatory responses in the asthmatic lung by bacterial infection and vaccination.$24,842

Funding body: Asthma Foundation of New South Wales

Funding bodyAsthma Foundation of New South Wales
Project TeamMs Julie Preston, Conjoint Professor Peter Gibson, Professor Phil Hansbro
SchemePhD Scholarships
RoleInvestigator
Funding Start2002
Funding Finish2002
GNoG0181606
Type Of FundingDonation - Aust Non Government
Category3AFD
UONY

Ultra Low Temperature Upright Freezer including Racks and Storage box for Viral Laboratory establishment$20,613

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamConjoint Professor Peter Gibson, Conjoint Associate Professor Michael Boyle, Emeritus Professor Michael Hensley, Associate Professor Darren Shafren
SchemeEquipment Grant
RoleLead
Funding Start2002
Funding Finish2002
GNoG0181920
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Treatment of asthma by vaccination with bacterial antigens$12,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Phil Hansbro, Conjoint Professor Peter Gibson, Conjoint Professor Kenneth Beagley
SchemeProject Grant
RoleInvestigator
Funding Start2002
Funding Finish2002
GNoG0181356
Type Of FundingInternal
CategoryINTE
UONY

20014 grants / $527,506

Virus induced asthma: mechanisms and management.$390,475

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamConjoint Professor Peter Gibson, Conjoint Associate Professor Michael Boyle, Emeritus Professor Michael Hensley, Conjoint Professor Peter Jones, Associate Professor Darren Shafren
SchemeProject Grant
RoleLead
Funding Start2001
Funding Finish2001
GNoG0179694
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Airways infection and immunology$94,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamConjoint Professor Peter Gibson
SchemeNSW Dept Health - Infrastructure Funding
RoleLead
Funding Start2001
Funding Finish2001
GNoG0183306
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Thermo Labsystem Luminoskan Ascent - Microplate Luminometer$23,031

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamConjoint Professor Peter Gibson, Conjoint Associate Professor Michael Boyle, Emeritus Professor Michael Hensley, Conjoint Professor Peter Jones, Associate Professor Darren Shafren
SchemeEquipment Grant
RoleLead
Funding Start2001
Funding Finish2001
GNoG0181176
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Oxidative stress and the antioxidant defences in asthmatic airways in relation to disease severity.$20,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamConjoint Professor Peter Gibson, Professor Manohar Garg
SchemeResearch Grant
RoleLead
Funding Start2001
Funding Finish2001
GNoG0181501
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

20001 grants / $238,678

Airway inflammation in allergic aspergillosis: characterisaion, immunologic mechanisms and treatment.$238,678

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamConjoint Professor Peter Gibson, Conjoint Associate Professor Michael Boyle, Emeritus Professor Michael Hensley, Dr Cliff Meldrum
SchemeProject Grant
RoleLead
Funding Start2000
Funding Finish2000
GNoG0178474
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

19983 grants / $147,000

Effect of severe asthma during pregnancy on placental function and fetal outcome$90,000

Funding body: Asthma Foundation of New South Wales

Funding bodyAsthma Foundation of New South Wales
Project TeamConjoint Associate Professor Vicki Clifton, Conjoint Professor Peter Gibson, Professor Roger Smith
SchemeResearch Grant
RoleInvestigator
Funding Start1998
Funding Finish1998
GNoG0177659
Type Of FundingDonation - Aust Non Government
Category3AFD
UONY

The investigation of airway inflammation and cell death in acute severe asthma$45,500

Funding body: Asthma Foundation of New South Wales

Funding bodyAsthma Foundation of New South Wales
Project TeamConjoint Professor Peter Gibson, Conjoint Professor Peter Wark
SchemeResearch Grant
RoleLead
Funding Start1998
Funding Finish1998
GNoG0177660
Type Of FundingDonation - Aust Non Government
Category3AFD
UONY

Effect of severe asthma during pregnancy on placental function and fetal outcome.$11,500

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamConjoint Associate Professor Vicki Clifton, Conjoint Professor Peter Gibson
SchemeProject Grant
RoleInvestigator
Funding Start1998
Funding Finish1998
GNoG0177211
Type Of FundingInternal
CategoryINTE
UONY

19972 grants / $421,869

Airway inflamation in childhood asthma$248,105

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamConjoint Professor Peter Gibson, Professor Richard Henry
SchemeProject Grant
RoleLead
Funding Start1997
Funding Finish1997
GNoG0176233
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

The Molecular Basis of Phagocytosis of Apoptotic Granulocytes$173,764

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Gordon Burns, Conjoint Professor Peter Gibson
SchemeProject Grant
RoleInvestigator
Funding Start1997
Funding Finish1997
GNoG0176242
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

19941 grants / $113,065

Eosinophils, Mast Cells and Airway Inflammation in Asthma.$113,065

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamConjoint Professor Peter Gibson
SchemeProject Grant
RoleLead
Funding Start1994
Funding Finish1994
GNoG0173004
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

19913 grants / $165,674

The role of airway inflammatory cells, adhesion proteins and cytokines in asthma$129,906

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamConjoint Professor Peter Gibson, Dr Leslie Olson
SchemeProject Grant
RoleLead
Funding Start1991
Funding Finish1991
GNoG0174252
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

The Role Of Food Additives In Asthma$25,293

Funding body: Asthma Foundation of New South Wales

Funding bodyAsthma Foundation of New South Wales
Project TeamConjoint Professor Peter Gibson
SchemeResearch Grant
RoleLead
Funding Start1991
Funding Finish1991
GNoG0173870
Type Of FundingDonation - Aust Non Government
Category3AFD
UONY

The Role Of Airway Inflammation In Asthma$10,475

Funding body: Rebecca L Cooper Medical Research Foundation Ltd

Funding bodyRebecca L Cooper Medical Research Foundation Ltd
Project TeamConjoint Professor Peter Gibson
SchemeResearch Grant
RoleLead
Funding Start1991
Funding Finish1991
GNoG0173992
Type Of FundingDonation - Aust Non Government
Category3AFD
UONY
Edit

Research Supervision

Current Supervision

CommencedResearch Title / Program / Supervisor Type
2014Physical Activity and Sedentary Behaviour in Obstructive Airway Diseases
General Medicine, Faculty of Health and Medicine
Co-Supervisor
2014The Effects of Galectin-3 on Alveolar Macrophage Function in Asthma
General Medicine, Faculty of Health and Medicine
Co-Supervisor
2013The Role of Comorbidities and Inflammation in COPD
General Medicine, Faculty of Health and Medicine
Principal Supervisor
2012Immunometabolism in Obese Asthma
General Medicine, Faculty of Health and Medicine
Principal Supervisor
2011Immunoregulatory Therapies for Inflammatory Diseases
Microbiology, Faculty of Health and Medicine
Co-Supervisor

Past Supervision

YearResearch Title / Program / Supervisor Type
2014Epigenetic Regulation of Airway Inflammation in Asthma
General Medicine, Faculty of Health and Medicine
Principal Supervisor
2014Systemic Inflammation in Obstructive Airway Disease
General Medicine, Faculty of Health and Medicine
Principal Supervisor
2013Paediatric Obesity, Inflammation and Asthma
General Medicine, Faculty of Health and Medicine
Co-Supervisor
2013Investigation of the Immune Mechanisms in Pregnancy and Asthma Leading to Increased Susceptibility and Disease Severity to Respiratory Virus Infections
General Medicine, Faculty of Health and Medicine
Principal Supervisor
2012Exploring the Link Between Obesity and Asthma
General Medicine, Faculty of Health and Medicine
Co-Supervisor
2011A Streptococcus pneumoniae-based Immunoregulatory Therapy for Asthma
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2011Asthma and COPD in Older People
General Medicine, Faculty of Health and Medicine
Principal Supervisor
2011Laryngeal Dysfunction in Chronic Cough
General Medicine, Faculty of Health and Medicine
Sole Supervisor
2009Nutritional Modulation of Lung Inflammation
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2009Evidence-Based Implementation of Evidence-Based Asthma Guidelines in Rural Hospital Emergency Departments
General Medicine, Faculty of Health and Medicine
Co-Supervisor
2008Modulation of Responses in the Asthmatic Lung by Chlamydial Infection
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2008Airway Inflammation in School-Aged Children with Asthma
General Medicine, Faculty of Health and Medicine
Principal Supervisor
2008Role of Lycopene and Long Chain n-3 Polyunsaturated Fatty Acid Supplements in Airway Inflammation
Human Biology, Faculty of Health and Medicine
Co-Supervisor
2008Molecular Pathogenesis of Non - Eosinophilic Asthma
Health, Faculty of Health and Medicine
Principal Supervisor
2007Modulation of Responses in the Asthmatic Lung by Streptococcus Pneumoniae
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2005Inflammatory Mechanisms in Non-Eosinophilic Asthma
General Medicine, Faculty of Health and Medicine
Sole Supervisor
Edit

News

New study to examine fibre effect on asthma

June 15, 2015

Respiratory researchers from the University of Newcastle and HMRI are looking into whether a high-fibre diet can reduce airway inflammation in people with asthma.

Asthma antibiotics

Asthma study trials antibiotic therapy

August 7, 2014

A national study investigating the use of antibiotics as a potential therapy for chronic asthma attacks is entering its final recruitment phase, five years after it commenced.

Professor Peter Gibson

Professor Gibson to present at NSW Asthma Foundation

November 11, 2013

The University of Newcastle's Conjoint Professor Peter Gibson will be presenting at the NSW Asthma Foundation's AGM on Tuesday 26 November 2013.

Conjoint Professor Peter Gibson

Position

Conjoint Professor
Centre for Asthma and Respiratory Diseases
School of Medicine and Public Health
Faculty of Health and Medicine

Contact Details

Emailpeter.gibson@newcastle.edu.au
Phone40420143
Mobile0408963976
Fax40420046

Office

RoomRm 2102, West Wing Level 2, HMRI
BuildingHMRI Building, 1 Kookaburra Circuit, JHH Campus
LocationHMRI - John Hunter Hospital Campus

,
Edit