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Conjoint Professor Peter Gibson

Conjoint Professor

School of Medicine and Public Health

Joining forces to ease the wheeze

Australia's two million sufferers of airway disease can breathe easier thanks to the work of the University's groundbreaking respiratory researchers.

Conjoint Professor Peter GibsonFrom the bench to the bedside, the University of Newcastle's Centre for Asthma and Respiratory Diseases is leading the way in the understanding, management and treatment of chronic airway conditions.

Centre co-directors Professor Paul Foster and Professor Peter Gibson lead highly talented teams of scientists and doctors who integrate the latest advances in laboratory technology and methodology with innovative, patient-focused research.

The work of the centre is internationally recognised, having contributed significantly to advancing both medical practice and policy through its discoveries.

Its studies are regularly published in the most prestigious journals and it is a major training hub for respiratory medicine and immunology, attracting gifted PhD students and postdoctoral researchers from around the world to work and study in Newcastle.

Foster and Gibson's teams work under the umbrella of the Hunter Medical Research Institute, a partnership between the University of Newcastle and Hunter New England Health. They also collaborate with research groups in Sydney, Newcastle, Melbourne and Perth as part of the Cooperative Research Centre for Asthma and Airways, a $55 million government-backed program.

Gibson is working at the clinical interface, using his role as a respiratory physician at the John Hunter Hospital in Newcastle to inform his research into treatments and management strategies for asthma and airway disease.

Foster, the University's Chair in Immunology, investigates the molecular and cellular mechanisms of disease in the laboratory. Both have a keen interest in unravelling the critical role of inflammation in asthma and other respiratory conditions.

"We are constantly on the lookout for better treatments but with a disease like asthma, management is also important," Gibson says.

"For some people, just understanding what is happening to them is enough to make a big difference to their condition and quality of life."

Gibson's clinically based team is involved in research projects with significant implications for future treatment and management of airway disease (see below).

Novel discoveries have also been made by the centre's laboratory-based researchers.  These discoveries have enhanced the understanding of processes associated with the development and progression of respiratory diseases.

Centre scientists study the cellular and molecular functions of the diseases on animal models then collaborate with the clinical researchers to validate their findings using human tissue.

Foster says the centre is at the forefront of interpreting how inflammation, which underpins airway disease, occurs and of developing new anti-inflammatory treatments.

A major breakthrough was their research into how microRNA molecules, which regulate protein production in human cells, can cause inflammation in the body that can manifest as asthma. Working out how to control that inflammatory response has provided scientists with a therapeutic target, which could lead to new treatments.

"Steroids are the conventional treatment, but they can have side effects and while they dampen response, they do not cure the disease," Foster explains.

"Also, not everyone is responsive to steroids and within that non-responsive group there is a lot of morbidity."

Foster says his team has made a significant contribution to the understanding of the mechanisms of steroid-resistant inflammatory pathways that may be relevant to asthma, bringing them closer to the goal of developing alternative treatments. Other critical areas of laboratory research focus on allergies, viruses and infection as triggers for asthma.

While the two arms of research within the centre are undertaken by different teams, Foster says it is the critical mass that contributes to its overall success.

"What we have is diversity and common interest," he says. "There are similar centres of excellence around the world but they primarily do either clinical-based research or basic immunology. The way the two are integrated here is what makes us unique and underpins our success."

"People are willing to collaborate," Gibson agrees, "and it is only by linking patient-focused research with laboratory discoveries and evidence-based medicine that we are able to get these broad insights into disease."

Leading the way

Professor Peter Gibson's clinical research team is leading three groundbreaking projects that could revolutionise the treatment of asthma.

These specific projects involve better management of asthma in pregnancy, the development of a blood test to diagnose the disease and the treatment of non-eosinophilic asthma with macrolide antibiotics.

The team's study into asthma in pregnancy was prompted by the reluctance of women to use treatments during gestation, even though severe asthmatic episodes can be harmful to both mother and child.

As part of this project, researchers measured nitric oxide, which is produced by inflamed airways, in the pregnant patient's exhaled breath. They were then able to adjust the amount of medication according to the severity of the inflammation.

In many cases this reduced the amount of steroid that needed to be administered, which made women more likely to take their medication as they were less apprehensive about the treatment and its effects on their unborn child.

Another benefit was that the frequency of asthma exacerbations, or episodes, decreased because the condition was being better managed.

In another study, published this year in the American Journal of Respiratory and Critical Care Medicine, the team used the emerging scientific field of proteomics (the study of proteins) to identify four blood-based biomarkers that when analysed together can distinguish between asthma and chronic obstructive pulmonary disease.

The two diseases share common symptoms, so are difficult to distinguish, but require different therapeutic approaches.

This finding could lead to the development of the first blood test for asthma, which would be a major diagnostic breakthrough.

The third project is the AMAZES study (Asthma and Macrolides: Azithromycin Efficacy and Safety). It will trial an alternative treatment, known as a macrolide antibiotic, for asthma that is not responsive to conventional steroid medication.

Steroids treat a particular cell, called an eosinophil, which is thought to provoke inflammation when present in increased levels. But research has established that up to half of adults with asthma symptoms have normal levels of eosinophils and respond poorly to conventional treatment.

The five-year, $2.9 million study is trialling the antibiotic on approximately 400 asthmatics in four cities and is the biggest study into non-eosinophilic asthma in the world.  It is funded by the National Health and Medical Research Council.

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Peter Gibson

Joining forces to ease the wheeze

The School of Medicine and Public Health is a multi-disciplinary team of researchers, many of whom are recognised as world-leaders in their field.

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Career Summary

Biography

Peter Gibson works as a doctor who cares for people with respiratory diseases and as a clinical scientist investigating the mechanisms and treatment of asthma, Chronic Obstructive Pulmonary Disease (COPD), cough, and other airway disorders.

He is a concept leader who has developed innovative approaches around inflammatory subtypes of asthma and cough; airway biomarkers; neurogenic mechanisms, laryngeal dysfunction and related treatments for refractory cough; multidimensional assessment and management of complex airway disorders such as severe asthma, airways diseases in the elderly, and asthma in pregnant women.

Peter's research metrics record a H index of 62 (Scopus 2015), 450 published articles, competitive research funding success, and effective mentorship of clinical researchers.  His peers have awarded Peter several research medals and elected him as the president of the Thoracic Society of Australia and New Zealand (2015-6).

His research, clinical practice, and participation in guideline panels serve to bring research developments into focus as effective health care interventions that improve the health of people suffering from breathing disorders.

Research Expertise
Inflammation and immunological mechanism of airway diseases such as asthma, COPD, and cough. Clinical assessment and treatment of airway diseases. Practice guidelines and policy of respiratory diseases.



Qualifications

  • Bachelor of Medicine & Surgery, University of New South Wales

Keywords

  • Asthma
  • COPD
  • Cough

Fields of Research

Code Description Percentage
110799 Immunology not elsewhere classified 20
110299 Cardiorespiratory Medicine and Haematology not elsewhere classified 80

Professional Experience

Academic appointment

Dates Title Organisation / Department
1/01/2009 - 1/12/2013 Fellow NHMRC

NHMRC - Practitioner Fellowships (Formerly Practioner Fellowships Scheme)

National Health & Medical Research Council
1/01/2004 - 1/12/2008 Fellowship

NHMRC - Practitioner Fellowships (Formerly Practioner Fellowships Scheme)

National Health & Medical Research Council
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Book (4 outputs)

Year Citation Altmetrics Link
2005 Gibson P, Abramson M, Wood-Baker R, Volmink J, Hensley M, Costabel U, Evidence-Based Respiratory Medicine, BMJ Books/Blackwell Pub, Malden, Mass., 608 (2005)
2005 Gibson PG, Monitoring Asthma, Taylor & Francis, Boca Raton, 576 (2005)
2005 Gibson P, Abramson M, Wood-Baker R, Volmink J, Hensley M, Costabel U, Evidence-Based Respiratory Medicine, BMJ Books/Blackwell Pub, Malden, Mass., 608 (2005)
2005 Gibson PG, Monitoring Asthma, Taylor & Francis, Boca Raton, 576 (2005)
Show 1 more book

Chapter (20 outputs)

Year Citation Altmetrics Link
2014 McDonald VM, Gibson PG, 'Asthma Education', Clinical Asthma, CRC Press, Bosa Roca/US 127-137 (2014) [B2]
DOI 10.1201/b16468-18
Co-authors Vanessa Mcdonald
2013 Scott H, Wood LG, Garg ML, Gibson PG, 'Asthma and Inflammation', Nutrition and Physical activity in inflammatory diseases, CABI, Oxford, UK 299-321 (2013) [B1]
Co-authors Lisa Wood, Manohar Garg, Hayley Scott
2013 Baines KJ, Simpson JL, Gibson PG, 'Biology of Neutrophils', Middleton's Allergy: Principles and Practice: Eighth Edition 280-191 (2013)
DOI 10.1016/B978-0-323-08593-9.00018-8
Citations Scopus - 1
Co-authors Jodie Simpson, Katherine Baines
2011 Gaga M, Zervas E, Gibson PG, 'Allergic and nonallergic factors in severe asthma', Difficult-to-Treat Severe Asthma, European Respiratory Society, Sheffield, UK 107-119 (2011) [B1]
DOI 10.1183/1025448x.10001210
2011 Gibson PG, Wang F, He XY, Brightling CE, 'Noninvasive assessment of inflammation in severe asthma', Difficult-to-Treat Severe Asthma, European Respiratory Society, Sheffield, UK 208-217 (2011) [B1]
DOI 10.1183/1025448x.10002110
2010 Murphy VE, Gibson PG, 'Asthma and rhinitis in pregnancy', Allergy Frontiers: Therapy and Prevention, Springer, Berlin 485-497 (2010) [B1]
Co-authors Vanessa Murphy
2010 Wark PA, Gibson PG, 'Pathogenesis of ABPA', Aspergillosis: From diagnosis to prevention, Springer, Berlin 695-706 (2010) [B1]
Co-authors Peter Wark
2009 Simpson JL, Baines KJ, Gibson PG, 'Biology of neutrophils', Middleton's Allergy: Principles & Practice, Mosby, Philadelphia, Pennsylvania 283-294 (2009) [B1]
Co-authors Katherine Baines, Jodie Simpson
2009 Murphy VE, Gibson PG, 'Asthma in pregnancy', Pulmonary Problems in Pregnancy, Humana Press, New York 143-164 (2009) [B1]
DOI 10.1007/978-1-59745-445-2
Co-authors Vanessa Murphy
2009 McDonald VM, Gibson PG, 'Asthma patient education', Allergy Frontiers: Diagnosis and Health Economics, Springer, Berlin 475-489 (2009) [B1]
DOI 10.1007/978-4-431-98349-1_26
Co-authors Vanessa Mcdonald
2008 Gibson PG, 'Clinical assessment of asthma', Clinical Asthma, Mosby, Maryland Heights, Missouri 119-126 (2008) [B1]
DOI 10.1016/b978-032304289-5.10013-x
2007 Powell H, Gibson PG, 'Role of self-management in preventing asthma exacerbations', Exacerbations of Asthma, Informa Healthcare, London, United Kingdom 307-320 (2007) [B1]
2007 Wood LG, Gibson PG, Garg ML, 'Alpha-tocopherol and cystic fibrosis', The Encyclopedia of Vitamin E, Centre for Agricultural Bioscience International, Wallingford, United Kingdom 708-718 (2007) [B1]
Co-authors Lisa Wood, Manohar Garg
2005 Gibson PG, simpson JL, 'Inflammatory mediators of asthma in children', Childhood Asthma, CRC Press, New York (2005)
Co-authors Jodie Simpson
2003 Gibson PG, Wark PAB, Simpson JL, 'Induced sputum studies in children', An Atlas of Induced Sputum An Aid for Research and Diagnosis, Taylor & Francis, USA (2003)
Co-authors Peter Wark, Jodie Simpson
2001 Gibson PG, Yates D, Saltos N, 'Examination of Sputum, Nasal Cytology and Exhaled Gases', Manual of Asthma Management, WB Saunders Company Ltd, London 107-118 (2001) [B1]
2001 Gibson PG, Boulet L-P, 'ROLE OF ASTHMA EDUCATION', Evidence-Based Asthma Management, B.C. Decker Inc., Hamilton, Ontario, Canada 275-290 (2001) [B2]
2001 Gibson PG, Simpson JL, 'Measurement of cytokines in induced sputum: application to the investigation of asthma and COPD', Interleukin Protocols, PennWell Corporation, USA (2001)
Co-authors Jodie Simpson
2001 Gibson PG, Simpson J, 'Measurement of Cytokines in Induced Sputum', Interleukin Protocols, Humana Press, Totowa, New Jersey 305-312 (2001) [B1]
2000 Gibson PG, Wilson A, 'Quality of life in asthma', Understanding asthma: a management companion, MacLennan & Petty Pty Limited, Sydney Australia 278-288 (2000) [B1]
Show 17 more chapters

Journal article (469 outputs)

Year Citation Altmetrics Link
2016 Li Q, Baines KJ, Gibson PG, Wood LG, 'Changes in expression of genes regulating airway inflammation following a high-fat mixed meal in asthmatics', Nutrients, 8 (2016) [C1]

© 2016 by the authors; licensee MDPI, Basel, Switzerland.Consumption of a high fat meal can increase neutrophilic airway inflammation in asthma subjects. This study investigates ... [more]

© 2016 by the authors; licensee MDPI, Basel, Switzerland.Consumption of a high fat meal can increase neutrophilic airway inflammation in asthma subjects. This study investigates the molecular mechanisms driving airway neutrophilia following a high fat meal in asthmatics. Subjects with asthma (n = 11) and healthy controls (n = 8) consumed a high-fat/energy meal, containing total energy (TE) of 3846 kJ and 48 g of total fat (20.5 g saturated). Sputum was induced at 0 and 4 h, and gene expression was examined by microarray and quantitative real-time PCR (qPCR). Following the high fat dietary challenge, 168 entities were significantly differentially expressed greater than >1.5 fold in subjects with asthma, whereas, in healthy controls, only 14 entities were differentially expressed. Of the 168 genes that were changed in asthma, several biological processes were overrepresented, with 25 genes involved in "immune system processes". qPCR confirmed that S100P, S100A16, MAL and MUC1 were significantly increased in the asthma group post-meal. We also observed a strong correlation and a moderate correlation between the change in NLRP12 and S100A16 gene expression at 4 h compared to baseline, and the change in total and saturated non-esterified plasma fatty acid levels at 2 h compared to baseline. In summary, our data identifies differences in inflammatory gene expression that may contribute to increased airway neutrophilia following a high fat meal in subjects with asthma and may provide useful therapeutic targets for immunomodulation. This may be particularly relevant to obese asthmatics, who are habitually consuming diets with a high fat content.

DOI 10.3390/nu8010030
Co-authors Katherine Baines, Lisa Wood
2016 Simpson JL, Carroll M, Yang IA, Reynolds PN, Hodge S, James AL, et al., 'Reduced Antiviral Interferon Production in Poorly Controlled Asthma Is Associated With Neutrophilic Inflammation and High-Dose Inhaled Corticosteroids.', Chest, 149 704-713 (2016)
DOI 10.1016/j.chest.2015.12.018
Co-authors Jodie Simpson
2016 Ballantyne D, Scott H, MacDonald-Wicks L, Gibson PG, Wood L, 'Resistin is a predictor of asthma risk and resistin: adiponectin ratio is a negative predictor of lung function in asthma.', Clin Exp Allergy, (2016)
DOI 10.1111/cea.12742
Citations Scopus - 1
Co-authors Lesley Wicks, Lisa Wood
2016 Hodge S, Upham JW, Pizzutto S, Petsky HL, Yerkovich S, Baines KJ, et al., 'Is Alveolar Macrophage Phagocytic Dysfunction in Children With Protracted Bacterial Bronchitis a Forerunner to Bronchiectasis?', Chest, 149 508-515 (2016)
DOI 10.1016/j.chest.2015.10.066
Citations Scopus - 1
Co-authors Jodie Simpson, Katherine Baines
2016 Steel K, Gibson P, Murphy V, 'ASTHMA SELF-MANAGEMENT EDUCATION AND INHALED CORTICOSTEROID USE DURING PREGNANCY AND POSTPARTUM FROM 2004 TO 2014', RESPIROLOGY, 21 23-23 (2016)
Co-authors Vanessa Murphy
2016 Jensen M, Murphy V, Mattes J, Gibson P, Carmargo JC, 'MATERNAL SERUM VITAMIN D LEVELS >= 75 NMOL/L DURING PREGNANCY ARE ASSOCIATED WITH FEWER ADVERSE RESPIRATORY OUTCOMES IN INFANTS AT 12 MONTHS OF AGE', RESPIROLOGY, 21 51-51 (2016)
Co-authors Joerg Mattes, Vanessa Murphy
2016 Nguyen TH, Maltby S, Simpson JL, Eyers F, Baines KJ, Gibson PG, et al., 'TNF-a and Macrophages Are Critical for Respiratory Syncytial Virus-Induced Exacerbations in a Mouse Model of Allergic Airways Disease.', J Immunol, 196 3547-3558 (2016)
DOI 10.4049/jimmunol.1502339
Co-authors Paul Foster, Katherine Baines, Jodie Simpson, Ming Yang, Steven Maltby
2016 Porsbjerg C, Baines K, Gibson P, Bergqvist A, Erjefält JS, Sverrild A, Backer V, 'IL-33 is related to innate immune activation and sensitization to HDM in mild steroid-free asthma.', Clin Exp Allergy, 46 564-574 (2016)
DOI 10.1111/cea.12702
2016 Chang AB, Upham JW, Masters IB, Redding GR, Gibson PG, Marchant JM, Grimwood K, 'Protracted bacterial bronchitis: The last decade and the road ahead', Pediatric Pulmonology, 51 225-242 (2016)

© 2015 Wiley Periodicals, Inc.Cough is the single most common reason for primary care physician visits and, when chronic, a frequent indication for specialist referrals. In child... [more]

© 2015 Wiley Periodicals, Inc.Cough is the single most common reason for primary care physician visits and, when chronic, a frequent indication for specialist referrals. In children, a chronic cough (>4 weeks) is associated with increased morbidity and reduced quality of life. One common cause of childhood chronic cough is protracted bacterial bronchitis (PBB), especially in children aged <6 years. PBB is characterized by a chronic wet or productive cough without signs of an alternative cause and responds to 2 weeks of appropriate antibiotics, such as amoxicillin-clavulanate. Most children with PBB are unable to expectorate sputum. If bronchoscopy and bronchoalveolar lavage are performed, evidence of bronchitis and purulent endobronchial secretions are seen. Bronchoalveolar lavage specimens typically reveal marked neutrophil infiltration and culture large numbers of respiratory bacterial pathogens, especially Haemophilus influenzae. Although regarded as having a good prognosis, recurrences are common and if these are frequent or do not respond to antibiotic treatments of up to 4-weeks duration, the child should be investigated for other causes of chronic wet cough, such as bronchiectasis. The contribution of airway malacia and pathobiologic mechanisms of PBB remain uncertain and, other than reduced alveolar phagocytosis, evidence of systemic, or local immune deficiency is lacking. Instead, pulmonary defenses show activated innate immunity and increased gene expression of the interleukin-1ß signalling pathway. Whether these changes in local inflammatory responses are cause or effect remains to be determined. It is likely that PBB and bronchiectasis are at the opposite ends of the same disease spectrum, so children with chronic wet cough require close monitoring. Pediatr Pulmonol. 2016;51:225-242.

DOI 10.1002/ppul.23351
2016 Hodge S, Hodge G, Simpson JL, Yang IA, Upham J, James A, et al., 'Blood cytotoxic/inflammatory mediators in non-eosinophilic asthma', Clinical and Experimental Allergy, 46 60-70 (2016) [C1]

© 2016 John Wiley & Sons Ltd.Background: Non-eosinophilic asthma (NEA) is a distinct, often corticosteroid-resistant inflammatory asthma phenotype. NK and NKT-like cells are effe... [more]

© 2016 John Wiley & Sons Ltd.Background: Non-eosinophilic asthma (NEA) is a distinct, often corticosteroid-resistant inflammatory asthma phenotype. NK and NKT-like cells are effector lymphocytes that we have shown, like CD28null T cells, to be relatively resistant to steroids and major sources of pro-inflammatory/cytotoxic mediators. We hypothesized that these cells and mediators would be increased in peripheral blood in NEA. Methods: Adults with severe asthma and variable airflow obstruction, poorly controlled despite maintenance therapy with inhaled glucocorticosteroids and long-acting bronchodilators, were recruited. Blood was assessed in those with eosinophilic asthma (n = 12), NEA (n = 25) and healthy non-smoking controls (n = 30). We applied flow cytometry to measure T, CD28null, NK and NKT-like cells and their expression of granzyme B, perforin, and killer inhibitory/activating receptors CD94(Kp43), CD158b and CD107A. Intracellular pro-inflammatory cytokine production (IFN-¿ and TNF-a) was assessed in 18 controls and 10 patients with asthma/group. Results: In NEA, there was increased expression of granzyme B by CD8+ T cells vs. controls. There was increased expression of granzyme B and CD158 and decreased CD94 on NK cells, vs. healthy controls and those with eosinophilic asthma. IFN-¿ production by NK cells and TNF-a production by NKT-like cells in NEA were significantly increased vs. controls. In both eosinophilic and NEA phenotypes, there were significant increases in CD4+28null T cells (72% and 81% increases, respectively, vs. controls) and their expression of pro-inflammatory cytokines. Significant correlations were noted between blood CD4+28null T cells and neutrophil numbers in induced sputum, and between corticosteroid dose and blood NKT-like cells, and their production of granzyme B and TNF-a and NK IFN-¿. Conclusion and clinical relevance: In poorly controlled asthma, altered expression of cytotoxic/pro-inflammatory mediators can be seen on a variety of lymphocyte subsets in the peripheral blood; these changes are most apparent in NEA. Whether this pattern of expression is a marker of treatment responsiveness and future risk of exacerbations remains to be determined.

DOI 10.1111/cea.12634
Co-authors Jodie Simpson
2016 Gibson P, Wang G, McGarvey L, Vertigan AE, Altman KW, Birring SS, 'Treatment of unexplained chronic cough chest guideline and expert panel report', Chest, 149 27-44 (2016)

BACKGROUND: Unexplained chronic cough (UCC) causes significant impairments in quality of life. Effective assessment and treatment approaches are needed for UCC. METHODS: This syst... [more]

BACKGROUND: Unexplained chronic cough (UCC) causes significant impairments in quality of life. Effective assessment and treatment approaches are needed for UCC. METHODS: This systematic review of randomized controlled trials (RCTs) asked: What is the efficacy of treatment compared with usual care for cough severity, cough frequency, and cough-related quality of life in patients with UCC? Studies of adults and adolescents aged 12 years with a chronic cough of 8 weeks' duration that was unexplained after systematic investigation and treatment were included and assessed for relevance and quality. Based on the systematic review, guideline suggestions were developed and voted on by using the American College of Chest Physicians organization methodology. RESULTS: Eleven RCTs and five systematic reviews were included. The 11 RCTs reported data on 570 participants with chronic cough who received a variety of interventions. Study quality was high in 10 RCTs. The studies used an assortment of descriptors and assessments to identify UCC. Although gabapentin and morphine exhibited positive effects on cough-related quality of life, only gabapentin was supported as a treatment recommendation. Studies of inhaled corticosteroids (ICS) were affected by intervention fidelity bias; when this factor was addressed, ICS were found to be ineffective for UCC. Esomeprazole was ineffective for UCC without features of gastroesophageal acid reflux. Studies addressing nonacid gastroesophageal reflux disease were not identified. A multimodality speech pathology intervention improved cough severity. CONCLUSIONS: The evidence supporting the diagnosis and management of UCC is limited. UCC requires further study to establish agreed terminology and the optimal methods of investigation using established criteria for intervention fidelity. Speech pathology-based cough suppression is suggested as a treatment option for UCC. This guideline presents suggestions for diagnosis and treatment based on the best available evidence and identifies gaps in our knowledge as well as areas for future research. Copyright © 2016 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.

DOI 10.1378/chest.15-1496
Citations Scopus - 2
2016 Simpson JL, Baines KJ, Horvat JC, Essilfie AT, Brown AC, Tooze M, et al., 'COPD is characterized by increased detection of Haemophilus influenzae, Streptococcus pneumoniae and a deficiency of Bacillus species', Respirology, 21 697-704 (2016) [C1]

© 2016 Asian Pacific Society of Respirology.Background and objective Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow limitation and inflammat... [more]

© 2016 Asian Pacific Society of Respirology.Background and objective Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow limitation and inflammation. Airway bacterial colonization is increased in COPD; however, the role of potentially pathogenic and non-pathogenic bacteria in the pathogenesis of disease is unclear. This study characterized the presence of bacteria in a well-characterized cohort of adults with COPD and healthy controls. Methods Adults with COPD (n = 70) and healthy controls (n = 51) underwent clinical assessment and sputum induction. Sputum was dispersed, and total and differential cell counts were performed. Bacteria were cultured, identified and enumerated. Supernatants were assessed for neutrophil elastase (NE) and IL-1ß. Common respiratory pathogens were also determined using real-time PCR. Results Participants with COPD had a typical neutrophilic inflammatory profile. The total load of bacteria was increased in COPD and was associated with poorer respiratory health status, as measured by the St George's Respiratory Questionnaire (Spearman's r = 0.336, P = 0.013). Significantly lower levels of culturable Bacillus species were identified compared with healthy controls. PCR analyses revealed increased rates of detection of potentially pathogenic bacteria with Haemophilus influenzae detection associated with higher sputum levels of NE and IL-1ß, while Streptococcus pneumoniae was more common in male ex-smokers with emphysema and a deficit in diffusion capacity. Conclusion Non-pathogenic and pathogenic bacteria were altered in the sputum of patients with COPD. These observations highlight the potential to identify treatment and management strategies that both target specific bacterial pathogens and restore the microbial balance, which may lead to reductions in inflammation and subsequent improvements in lung health.

DOI 10.1111/resp.12734
Co-authors Philip Hansbro, Jay Horvat, Vanessa Mcdonald, Jodie Simpson, Katherine Baines
2016 Murphy V, Gibson P, 'THE USE OF FRACTIONAL EXHALED NITRIC OXIDE-BASED MANAGEMENT FOR NON-EOSINOPHILIC ASTHMA DURING PREGNANCY', RESPIROLOGY, 21 93-93 (2016)
Co-authors Vanessa Murphy
2016 Wright TK, Gibson PG, Simpson JL, McDonald VM, Wood LG, Baines KJ, 'Neutrophil extracellular traps are associated with inflammation in chronic airway disease.', Respirology, 21 467-475 (2016)
DOI 10.1111/resp.12730
Co-authors Katherine Baines, Jodie Simpson, Vanessa Mcdonald, Lisa Wood
2016 Vertigan AE, Kapela SL, Ryan NM, Birring SS, McElduff P, Gibson PG, 'Pregabalin and Speech Pathology Combination Therapy for Refractory Chronic Cough: A Randomized Controlled Trial.', Chest, 149 639-648 (2016)
DOI 10.1378/chest.15-1271
Citations Scopus - 1
Co-authors Nicole Ryan
2016 Brooks CR, Van Dalen CJ, Zacharasiewicz A, Simpson JL, Harper JL, Le Gros G, et al., 'Absence of airway inflammation in a large proportion of adolescents with asthma', Respirology, 21 460-466 (2016)

© 2015 Asian Pacific Society of Respirology.Background and objective Neutrophilic inflammation has been implicated in non-eosinophilic asthma (NEA) in adults, but little is known... [more]

© 2015 Asian Pacific Society of Respirology.Background and objective Neutrophilic inflammation has been implicated in non-eosinophilic asthma (NEA) in adults, but little is known about NEA in children/adolescents. We assessed clinical and inflammatory characteristics of NEA in adolescent asthma. Methods Airway inflammation, sputum endotoxin, airway hyper-reactivity, atopy and lung function were assessed in 77 adolescents with asthma and 68 without asthma (12-17 years). Asthma was identified on the basis of wheeze and asthma history. Results The proportion of NEA (sputum eosinophils <2.5%) was 54%. In this group, atopy, sputum neutrophil, eosinophil, eosinophil cationic protein (ECP), endotoxin, neutrophil elastase and IL-8 levels were not different from those without asthma. In contrast, eosinophilic asthma (EA) was associated with atopy and sputum ECP and IL-8. The majority of NEA had no evidence of inflammation; only 14% had neutrophilia (=61% neutrophils), compared with 11% of EA, and 15% of those without asthma. Small differences in FEV1 (NS) were found between EA and NEA, but symptom prevalence and severity was not different (63% of EA and 52% of NEA were classified moderate to severe). Conclusion NEA is common in adolescent asthma and has similar clinical characteristics as EA. Neutrophils do not appear to play a role in NEA in adolescents, and underlying mechanisms may not involve airway inflammation. Our study suggests that many adolescents with stable asthma do not appear to correspond to the conventional notion that asthma is 'an inflammatory disorder of the airways'. In the absence of overt inflammation, the mechanisms responsible for asthma symptoms in a large proportion of adolescent with asthma remain unknown.

DOI 10.1111/resp.12701
Citations Scopus - 1
Co-authors Jodie Simpson
2016 Sverrild A, Bergqvist A, Baines KJ, Porsbjerg C, Andersson CK, Thomsen SF, et al., 'Airway responsiveness to mannitol in asthma is associated with chymase-positive mast cells and eosinophilic airway inflammation', Clinical and Experimental Allergy, 46 288-297 (2016) [C1]

© 2016 John Wiley & Sons Ltd.Background: Airway hyperresponsiveness (AHR) to inhaled mannitol is associated with indirect markers of mast cell activation and eosinophilic airway ... [more]

© 2016 John Wiley & Sons Ltd.Background: Airway hyperresponsiveness (AHR) to inhaled mannitol is associated with indirect markers of mast cell activation and eosinophilic airway inflammation. It is unknown how AHR to mannitol relates to mast cell phenotype, mast cell function and measures of eosinophilic inflammation in airway tissue. We compared the number and phenotype of mast cells, mRNA expression of mast cell-associated genes and number of eosinophils in airway tissue of subjects with asthma and healthy controls in relation to AHR to mannitol. Methods: Airway hyperresponsiveness to inhaled mannitol was measured in 23 non-smoking, corticosteroid-free asthmatic individuals and 10 healthy controls. Mast cells and eosinophils were identified in mucosal biopsies from all participants. Mast cells were divided into phenotypes based on the presence of chymase. mRNA expression of mast cell-associated genes was measured by real-time PCR. Results: The proportion of submucosal MCTC was higher in asthmatic individuals with AHR to mannitol compared with asthmatic individuals without AHR (median: 40.3% vs. 18.7%, P=0.03). Increased submucosal MCTC numbers were associated with increased levels of mRNA for thymic stromal lymphopoietin (TSLP) and CPA3 in asthmatics. Reactivity to mannitol correlated significantly with eosinophils in submucosa (r(s): 0.56, P=0.01). Conclusion: Airway hyperresponsiveness to inhaled mannitol is associated with an altered submucosal mast cell profile in asthmatic individuals. This mast cell profile is associated with increased levels of TSLP and CPA3. The degree of AHR to mannitol is correlated with the degree of eosinophilic inflammation in the airway submucosa.

DOI 10.1111/cea.12609
Citations Scopus - 2
Co-authors Katherine Baines
2016 Agusti A, Bel E, Thomas M, Vogelmeier C, Brusselle G, Holgate S, et al., 'Treatable traits: toward precision medicine of chronic airway diseases.', Eur Respir J, 47 410-419 (2016)
DOI 10.1183/13993003.01359-2015
Citations Scopus - 10
2016 Murphy VE, Jensen ME, Mattes J, Hensley MJ, Giles WB, Peek MJ, et al., 'The Breathing for Life Trial: a randomised controlled trial of fractional exhaled nitric oxide (FENO)-based management of asthma during pregnancy and its impact on perinatal outcomes and infant and childhood respiratory health.', BMC Pregnancy Childbirth, 16 111 (2016)
DOI 10.1186/s12884-016-0890-3
Co-authors Michael Hensley, Joerg Mattes, Vanessa Murphy, John Attia
2016 Thorburn AN, Tseng HY, Donovan C, Hansbro NG, Jarnicki AG, Foster PS, et al., 'TLR2, TLR4 AND MyD88 Mediate Allergic Airway Disease (AAD) and Streptococcus pneumoniae-Induced Suppression of AAD.', PLoS One, 11 e0156402 (2016)
DOI 10.1371/journal.pone.0156402
Co-authors Paul Foster, Philip Hansbro
2016 Simpson JL, Yang IA, Upham JW, Reynolds PN, Hodge S, James AL, et al., 'Periostin levels and eosinophilic inflammation in poorly-controlled asthma.', BMC Pulm Med, 16 67 (2016)
DOI 10.1186/s12890-016-0230-4
Co-authors Jodie Simpson
2016 Zosky GR, Hoy RF, Silverstone EJ, Brims FJ, Miles S, Johnson AR, et al., 'Coal workers¿ pneumoconiosis: An Australian perspective', Medical Journal of Australia, 204 414-418.e2 (2016)

© 2016 AMPCo Pty Ltd. Produced with Elsevier B.V. All rights reserved.Coal workers¿ pneumoconiosis (CWP) is an untreatable but preventable lung disease arising from chronic inha... [more]

© 2016 AMPCo Pty Ltd. Produced with Elsevier B.V. All rights reserved.Coal workers¿ pneumoconiosis (CWP) is an untreatable but preventable lung disease arising from chronic inhalation of coal dust. Recent reports of CWP in Queensland, along with international data, suggest that there is a resurgence in pneumoconiosis. The prevalence of CWP varies considerably between countries. In Australia, there is no mandatory reporting system and no national data on the prevalence of CWP. The symptoms and manifestations of CWP vary depending on the composition of the inhaled dust, duration of exposure, stage of disease and host-related factors. CWP may develop into progressive massive fibrosis (PMF), which can be fatal. Radiological assessment should be performed according to evidence-based standards using the ILO (International Labour Office) International Classification of Radiographs of Pneumoconioses. As preventing exposure to coal dust prevents CWP, it is important to implement and enforce appropriate standards limiting exposure. In Australia, these standards currently vary between states and are not in keeping with international understanding of the levels of coal dust that cause disease. Longitudinal screening programs are crucial for monitoring the health of coal workers to identify individuals with early-stage disease and prevent progression from mild disease to PMF. We recommend: standardisation of coal dust exposure limits, with harmonisation to international regulations; implementation of a national screening program for at-risk workers, with use of standardised questionnaires, imaging and lung function testing; development of appropriate training materials to assist general practitioners in identifying pneumoconiosis; and a system of mandatory reporting of CWP to a centralised occupational lung disease register.

DOI 10.5694/mja16.00357
2016 Dong Z, Xiong L, Zhang W, Gibson PG, Wang T, Lu Y, et al., 'Holding the Inflammatory System in Check: TLRs and Their Targeted Therapy in Asthma', Mediators of Inflammation, 2016 (2016)

© 2016 Zhiyong Dong et al.Inflammation is a complex biological response to detrimental stimuli and can be a double-edged sword. Inflammation plays a protective role in removing p... [more]

© 2016 Zhiyong Dong et al.Inflammation is a complex biological response to detrimental stimuli and can be a double-edged sword. Inflammation plays a protective role in removing pathogenic factors, but dysregulated inflammation is associated with several major fatal diseases such as asthma, cancer, and cardiovascular diseases. Asthma is a complex heterogenous disease caused by genetic and environmental factors. TLRs are the primary proteins associated with the innate and adaptive immune responses to these fatal factors and play an important role in recognizing pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs), which initiates the downstream immune response. Due to the complex TLRs cascade and nowadays unsuccessful control in asthma, new studies are focused on TLRs and other potential targets in TLR cascade to minimize airway inflammation.

DOI 10.1155/2016/2180417
Citations Scopus - 1
2016 Periyalil H, Wood L, Karihaloo C, Wright T, Gibson P, 'OBESE ASTHMATICS ARE CHARACTERISED BY ALTERED ADIPOSE TISSUE MACROPHAGE ACTIVATION', RESPIROLOGY, 21 44-44 (2016)
2016 Jensen M, Wood L, Gibson P, Garg M, 'NEUTROPHIL ACTIVITY IS HIGHER IN OVERWEIGHT, VERSUS HEALTHY-WEIGHT, ADULTS WITH ASTHMA, BUT DECREASES FOLLOWING A 14-WEEK DIETARY INTERVENTION', RESPIROLOGY, 21 73-73 (2016)
2016 Wood L, Ballantyne D, Scott H, Mcdonald-Wicks L, Gibson P, 'RESISTIN AND RESISTIN : ADIPONECTIN RATIO AS PREDICTORS OF LUNG FUNCTION IN ASTHMA', RESPIROLOGY, 21 73-73 (2016)
2016 Wood L, Halnes I, Baines K, Mcdonald-Wicks L, Gibson P, 'A SOLUBLE FIBRE SUPPLEMENT REDUCES AIRWAY INFLAMMATION IN ASTHMA', RESPIROLOGY, 21 74-74 (2016)
2016 Scott H, Gibson P, Grag M, Upham J, Wood L, 'SEX HORMONES AND SYSTEMIC CYTOKINES ARE INDEPENDENT MODULATORS OF THE OBESE-ASTHMA PHENOTYPE', RESPIROLOGY, 21 74-74 (2016)
2016 Hew M, Gillman A, Sutherland M, Wark P, Bowden J, Macdonald V, et al., 'CLINICAL EFFECTIVENESS OF OMALIZUMAB IN SEVERE ALLERGIC ASTHMA ABOVE THE STANDARD DOSING RANGE: THE AUSTRALIAN XOLAIR REGISTRY', RESPIROLOGY, 21 102-102 (2016)
2016 Hu X, Gibson P, Wark P, 'IMPACT OF A STORM RELATED POWER OUTAGE ON PATIENTS REQUIRING LONG TERM DOMICILIARY RESPIRATORY SUPPORT IN THE HUNTER REGION', RESPIROLOGY, 21 146-146 (2016)
2016 Hew M, Gillman A, Sutherland M, Wark P, Bowden J, Guo M, et al., 'Real-life effectiveness of omalizumab in severe allergic asthma above the recommended dosing range criteria.', Clin Exp Allergy, (2016)
DOI 10.1111/cea.12774
Co-authors Peter Wark, Vanessa Mcdonald
2016 Vertigan A, Kapela S, Ryan NM, Birring S, McElduff P, Gibson P, 'Pregabalin and speech pathology combination therapy for refractory chronic cough: A randomised controlled trial.', Chest, 149 639-648 (2016)
DOI 10.1378/chest
2016 Scott HA, Gibson PG, Garg ML, Upham JW, Wood LG, 'Sex hormones and systemic inflammation are modulators of the obese-asthma phenotype.', Allergy, 71 1037-1047 (2016)
DOI 10.1111/all.12891
Co-authors Manohar Garg, Hayley Scott, Lisa Wood
2016 Simpson JL, Daly J, Baines KJ, Yang IA, Upham JW, Reynolds PN, et al., 'Airway dysbiosis: Haemophilus influenza and Tropheryma in poorly controlled asthma', European Respiratory Journal, 47 792-800 (2016) [C1]

© ERS 2016.Asthma is a chronic inflammatory disorder of the airways where bacteria may act as protagonists of chronic inflammation. Little is known about the relation of airway i... [more]

© ERS 2016.Asthma is a chronic inflammatory disorder of the airways where bacteria may act as protagonists of chronic inflammation. Little is known about the relation of airway inflammation to the presence of specific bacterial taxa. We sought to describe the sputum microbiome in adults with poorly controlled asthma. DNA was extracted from induced sputum and microbial communities were profiled using 16S rRNA pyrosequencing. Bacterial species were characterised, and the relationship between microbial populations, asthma inflammatory subtypes and other covariates was explored. Real-time PCR was used to identify Tropheryma whipplei and Haemophilus influenzae in sputum. Adults with neutrophilic asthma had reduced bacterial diversity and species richness. Tropheryma was identified and confirmed with real-time PCR in 12 (40%) participants. Haemophilus occurred most often in a group of younger atopic males with an increased proportion of neutrophils. PCR confirmed the presence of H. influenzae in 35 (76%) participants with poorly controlled asthma. There are phenotype-specific alterations to the airway microbiome in asthma. Reduced bacterial diversity combined with a high prevalence of H. influenzae was observed in neutrophilic asthma, whereas eosinophilic asthma had abundant T. whipplei.

DOI 10.1183/13993003.00405-2015
Co-authors Jodie Simpson, Katherine Baines
2016 Wang G, Baines KJ, Fu JJ, Wood LG, Simpson JL, McDonald VM, et al., 'Sputum mast cell subtypes relate to eosinophilia and corticosteroid response in asthma.', Eur Respir J, 47 1123-1133 (2016)
DOI 10.1183/13993003.01098-2015
Citations Scopus - 1
Co-authors Lisa Wood, Katherine Baines, Vanessa Mcdonald, Jodie Simpson
2016 Williams EJ, Baines KJ, Smart JM, Gibson PG, Wood LG, 'Rosuvastatin, lycopene and omega-3 fatty acids: A potential treatment for systemic inflammation in COPD; a pilot study', Journal of Nutrition and Intermediary Metabolism, 5 86-95 (2016)

© 2016 The AuthorsBackground/Aims Chronic Obstructive Pulmonary Disease (COPD) is characterized by airway inflammation, in which contributes to loss of lung function. Systemic in... [more]

© 2016 The AuthorsBackground/Aims Chronic Obstructive Pulmonary Disease (COPD) is characterized by airway inflammation, in which contributes to loss of lung function. Systemic inflammation is also a feature of COPD contributing to many associated co-morbidities. Statins, omega-3 fatty acids (docosahexanoic acid, DHA and eicosapentanoic acid, EPA) and lycopene have been shown to decrease systemic inflammation; however their combined effects have not been investigated. This study aims to identify changes in systemic and airway inflammation induced by statins alone or in combination with DHA, EPA and lycopene in COPD. Methods COPD patients (n¿=¿11) received rosuvastatin (20¿mg/day) for 4 weeks, then a combination of rosuvastatin (20¿mg/day), DHA and EPA (1.5¿g/day) and lycopene (45¿mg/day) for 8 weeks. Blood and sputum were collected and lung function measured by spirometry at baseline, week 4 and 12. Plasma fatty acids were measured using gas chromatography, while plasma carotenoids were analysed using high-performance liquid chromatography. Plasma CRP and IL-6 concentrations were measured using ELISA; and peripheral blood gene expression was measured using the nCounter¿ GX Human Inflammation Kit 2. Results Following the interventions, clinical characteristics and plasma IL-6 and CRP were unchanged. Sputum neutrophil proportion and absolute count was increased and macrophage proportion decreased by rosuvastatin (P¿=¿0.020 and P¿=¿0.015; respectively). Rosuvastatin increased LTB4R and decreased CXCL10 and AGER gene expression in white blood cells. The addition of lycopene and omega-3 fatty acids decreased LTB4R and increased CXCL10 to basal levels, whilst combined use of interventions increased ALOX15 blood gene expression. Conclusion This study shows that rosuvastatin, omega-3 fatty acids and lycopene have some anti-inflammatory effects systemically, but rosuvastatin may increase airway neutrophils, which would be undesirable in COPD patients, warranting further investigation.

DOI 10.1016/j.jnim.2016.04.006
Co-authors Lisa Wood, Katherine Baines
2016 McDonald VM, Gibson PG, Scott HA, Baines PJ, Hensley MJ, Pretto JJ, Wood LG, 'Should we treat obesity in COPD? The effects of diet and resistance exercise training.', Respirology, 21 875-882 (2016)
DOI 10.1111/resp.12746
Citations Scopus - 1
Co-authors Lisa Wood, Hayley Scott, Vanessa Mcdonald, Michael Hensley
2016 Kim R, Pinkerton J, Essilfie A, Robertson A, Baines K, Mayall J, et al., 'NLRP3 INFLAMMASOME- MEDIATED, IL-1 beta-DEPENDENT INFLAMMATORY RESPONSES DRIVE SEVERE, STEROID-INSENSITIVE ASTHMA', RESPIROLOGY, 21 46-46 (2016)
Co-authors Philip Hansbro, Jay Horvat, Peter Wark
2015 Periyalil HA, Wood LG, Scott HA, Jensen ME, Gibson PG, 'Macrophage activation, age and sex effects of immunometabolism in obese asthma', European Respiratory Journal, 45 388-395 (2015) [C1]

Copyright © ERS 2015.Obese asthma is characterised by infiltration of adipose tissue by activated macrophages and mast cells. The aim of this study was to examine the age and sex... [more]

Copyright © ERS 2015.Obese asthma is characterised by infiltration of adipose tissue by activated macrophages and mast cells. The aim of this study was to examine the age and sex effects of immunometabolism in obese asthma. Obese and non-obese asthmatic children and adults underwent spirometry, body composition assessment by dual energy X-ray absorptiometry and measurement of serum soluble CD163 (sCD163), tryptase, C-reactive protein (CRP) and other adipocytokines. Plasma CRP (p<0.01) and leptin (p<0.01) were elevated in obese asthmatic adults, and sCD163 (p=0.003) was elevated in obese asthmatic children. We observed significantly higher sCD163 in obese female children compared to obese female adults and male children, and higher CRP in obese female adults compared to obese male children and adults. Serum tryptase concentrations were not significantly different across age groups. sCD163 positively correlated with the proportion of android fat in obese female children (r=0.70, p=0.003) and obese female adults (r=0.65, p=0.003). In obese female children, sCD163 was inversely associated with forced expiratory volume in 1 s % predicted (r=-0.55, p=0.02) and was positively associated with the Asthma Control Questionnaire (r=0.57, p=0.02). Obese children with asthma have sex-specific macrophage activation, which may contribute to worse asthma control and lung function. The heterogeneous systemic inflammatory profile across age and sex suggests the existence of sub-phenotypes in obese asthma at the molecular level.

DOI 10.1183/09031936.00080514
Citations Scopus - 2Web of Science - 1
Co-authors Hayley Scott, Lisa Wood
2015 Berthon BS, Gibson PG, Mcelduff P, Macdonald-Wicks LK, Wood LG, 'Effects of short-term oral corticosteroid intake on dietary intake, body weight and body composition in adults with asthma - a randomized controlled trial', Clinical and Experimental Allergy, 45 908-919 (2015) [C1]

© 2015 John Wiley & Sons Ltd.Background: Oral corticosteroids (OCS) are an efficacious treatment for asthma exacerbations, yet risk of adverse effects may decrease patient adhere... [more]

© 2015 John Wiley & Sons Ltd.Background: Oral corticosteroids (OCS) are an efficacious treatment for asthma exacerbations, yet risk of adverse effects may decrease patient adherence to therapy. In particular, changes in appetite and dietary intake, which lead to weight gain and changes in body composition, are considered undesirable. Objective: To determine whether 10-day OCS therapy in adults with asthma causes changes in leptin, appetite, dietary intake, body weight and body composition. Methods: Double-blinded, placebo-controlled randomized cross-over trial of 10 days prednisolone (50 mg) in adults with stable asthma (n = 55) (ACTRN12611000562976). Pre- and post-assessment included spirometry, body weight, body composition measured by dual-energy X-ray absorptiometry and bioelectrical impedance analysis, appetite measured using a validated visual analogue scale (VAS) and dietary intake assessed using 4-day food records. Leptin was measured as a biomarker of appetite and eosinophils as an adherence biomarker. Outcomes were analysed by generalized linear mixed models. Results: Subject adherence was confirmed by a significant decrease in blood eosinophils (× 109/L) following prednisolone compared to placebo [Coef. -0.29, 95% CI: (-0.39, -0.19) P < 0.001]. There was no difference in serum leptin (ng/mL) [Coef. 0.13, 95% CI: (-3.47, 3.72) P = 0.945] or appetite measured by VAS (mm) [Coef. -4.93, 95% CI: (-13.64, 3.79) P = 0.267] following prednisolone vs. placebo. There was no difference in dietary intake (kJ/day) [Coef. 255, 95% CI: (-380, 891) P = 0.431], body weight (kg) [Coef. -0.38, 95% CI: (-0.81, 0.05) P = 0.083] or body fat (%) [Coef. -0.31, 95% CI: (-0.81, 0.20) P = 0.230]. Symptoms including sleep and gastrointestinal disturbance were reported significantly more often during prednisolone vs. placebo. Conclusions and Clinical Relevance: Short-term OCS in stable asthma did not induce significant changes in appetite, dietary intake, body weight or composition, although other adverse effects may require medical management. This evidence may assist in increasing medication adherence of asthmatics prescribed OCS for exacerbations.

DOI 10.1111/cea.12505
Citations Scopus - 2Web of Science - 1
Co-authors Lisa Wood, Lesley Wicks
2015 Essilfie A, Horvat JC, Kim RY, Mayall JR, Pinkerton JW, Beckett EL, et al., 'Macrolide therapy suppresses key features of experimental steroid-sensitive and steroid-insensitive asthma', Thorax Journal, 70 458-467 (2015) [C1]
DOI 10.1136/thoraxjnl-2014-206067
Citations Scopus - 12Web of Science - 2
Co-authors Paul Foster, Malcolm Starkey, Philip Hansbro, Jay Horvat, Jodie Simpson
2015 Thorburn AN, McKenzie CI, Shen S, Stanley D, MacIa L, Mason LJ, et al., 'Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites', Nature Communications, 6 (2015) [C1]

© 2015 Macmillan Publishers Limited. All rights reserved.Asthma is prevalent in Western countries, and recent explanations have evoked the actions of the gut microbiota. Here we ... [more]

© 2015 Macmillan Publishers Limited. All rights reserved.Asthma is prevalent in Western countries, and recent explanations have evoked the actions of the gut microbiota. Here we show that feeding mice a high-fibre diet yields a distinctive gut microbiota, which increases the levels of the short-chain fatty acid, acetate. High-fibre or acetate-feeding led to marked suppression of allergic airways disease (AAD, a model for human asthma), by enhancing T-regulatory cell numbers and function. Acetate increases acetylation at the Foxp3 promoter, likely through HDAC9 inhibition. Epigenetic effects of fibre/acetate in adult mice led us to examine the influence of maternal intake of fibre/acetate. High-fibre/acetate feeding of pregnant mice imparts on their adult offspring an inability to develop robust AAD. High fibre/acetate suppresses expression of certain genes in the mouse fetal lung linked to both human asthma and mouse AAD. Thus, diet acting on the gut microbiota profoundly influences airway responses, and may represent an approach to prevent asthma, including during pregnancy.

DOI 10.1038/ncomms8320
Citations Scopus - 15
Co-authors Joerg Mattes, Vanessa Murphy, Lisa Wood
2015 Wark PAB, McDonald VM, Gibson PG, 'Adjusting prednisone using blood eosinophils reduces exacerbations and improves asthma control in difficult patients with asthma.', Respirology, 20 1282-1284 (2015) [C1]
DOI 10.1111/resp.12602
Citations Scopus - 3
Co-authors Vanessa Mcdonald, Peter Wark
2015 Vanders RL, Murphy VE, Gibson PG, Hansbro PM, Wark PAB, 'CD8 T cells and dendritic cells: Key players in the attenuated maternal immune response to influenza infection', Journal of Reproductive Immunology, 107 1-9 (2015) [C1]

© 2014 Elsevier Ireland Ltd.Pregnancy provides a unique challenge for maternal immunity, requiring the ability to tolerate the presence of a semi-allogeneic foetus, and yet still... [more]

© 2014 Elsevier Ireland Ltd.Pregnancy provides a unique challenge for maternal immunity, requiring the ability to tolerate the presence of a semi-allogeneic foetus, and yet still being capable of inducing an immune response against invading pathogens. To achieve this, numerous changes must occur in the activity and function of maternal immune cells throughout the course of pregnancy. Respiratory viruses take advantage of these changes, altering the sensitive balance of maternal immunity, leaving the mother with increased susceptibility to viral infections and increased disease severity. Influenza virus is one of the most common respiratory virus infections during pregnancy, leading to an increased risk of ICU hospitalisations, pneumonia, acute respiratory distress syndrome and even death. Whilst much research has been performed to understand the changes that must take place in maternal immunity during pregnancy, considerable work is still needed to fully comprehend this tremendous feat. To date, few studies have focused on the alterations that occur in maternal immunity during respiratory virus infections. This review highlights the role of dendritic cells (DCs) and CD8 T cells during pregnancy, and the changes that occur in these antiviral cells following influenza virus infections.

DOI 10.1016/j.jri.2014.09.051
Citations Scopus - 2
Co-authors Peter Wark, Philip Hansbro, Vanessa Murphy
2015 Tang FSM, Foxley GJ, Gibson PG, Burgess JK, Baines KJ, Oliver BG, 'Altered Innate Immune Responses in Neutrophils from Patients with Well- and Suboptimally Controlled Asthma', Mediators of Inflammation, 2015 1-11 (2015) [C1]
DOI 10.1155/2015/219374
Co-authors Katherine Baines
2015 Wood LG, Shivappa N, Berthon BS, Gibson PG, Hebert JR, 'Dietary inflammatory index is related to asthma risk, lung function and systemic inflammation in asthma', Clinical and Experimental Allergy, 45 177-183 (2015) [C1]

© 2014 John Wiley & Sons Ltd.Background: Asthma prevalence has increased in recent years, and evidence suggests that diet may be a contributing factor. Increased use of processed... [more]

© 2014 John Wiley & Sons Ltd.Background: Asthma prevalence has increased in recent years, and evidence suggests that diet may be a contributing factor. Increased use of processed foods has led to a decrease in diet quality, which may be creating a pro-inflammatory environment, thereby leading to the development and/or progression of various chronic inflammatory diseases and conditions. Recently, the dietary inflammatory index (DII) has been developed and validated to assess the inflammatory potential of individual diets. Objective: This study aimed to examine the DII in subjects with asthma compared to healthy controls and to relate the DII to asthma risk, lung function and systemic inflammation. Methods: Subjects with asthma (n = 99) and healthy controls (n = 61) were recruited. Blood was collected and spirometry was performed. The DII was calculated from food frequency questionnaires administered to study subjects. Results: The mean DII score for the asthmatics was higher than the mean DII score for healthy controls (- 1.40 vs. - 1.86, P = 0.04), indicating that their diets were more pro-inflammatory. For every 1 unit increase in DII score, the odds of having asthma increased by 70% (OR: 1.70, 95% CI: 1.03, 2.14; P = 0.040). FEV1 was significantly associated with DII score (ß = - 3.44, 95% CI: - 6.50, - 0.39; P = 0.020), indicating that for every 1 unit increase in DII score, FEV1 decreased by 3.44 times. Furthermore, plasma IL-6 concentrations were positively associated with DII score (ß = 0.13, 95% CI: 0.05, 0.21; P = 0.002). Conclusion and Clinical Relevance: As assessed using the DII score, the usual diet consumed by asthmatics in this study was pro-inflammatory relative to the diet consumed by the healthy controls. The DII score was associated with increased systemic inflammation and lower lung function. Hence, consumption of pro-inflammatory foods may contribute to worse asthma status, and targeting an improvement in DII in asthmatics, as an indicator of suitable dietary intake, might be a useful strategy for improving clinical outcomes in the disease.

DOI 10.1111/cea.12323
Citations Scopus - 24Web of Science - 14
Co-authors Lisa Wood
2015 Baines KJ, Backer V, Gibson PG, Powell H, Porsbjerg CM, 'Investigating the effects of arctic dietary intake on lung health', European Journal of Clinical Nutrition, 69 1262-1266 (2015) [C1]

© 2015 Macmillan Publishers Limited.Background/Objective:Preservation of lung health requires understanding the modifiable risk factors of airflow limitation. This study investig... [more]

© 2015 Macmillan Publishers Limited.Background/Objective:Preservation of lung health requires understanding the modifiable risk factors of airflow limitation. This study investigates the association between diet and lung function in a population of Greenland Inuit residing in the Arctic (Greenland) or Western Europe (Denmark).Subjects/Methods:Two unselected Inuit populations were recruited, one living in Greenland (Urban (Nuuk) n=358; Rural (Uummannaq) n=207) and the other in Denmark (n=539). Lung function was measured using spirometry and diet by a food frequency questionnaire. Factors associated with airflow limitation were assessed using multiple linear regression models.Results:The dietary composition differed significantly in the two regions, with higher whale, seal and wild meat intake and lower fruit and vegetable intake in the Arctic regions compared with Denmark. Consumption of vegetables (P=0.004) and whale and/or seal (P<0.0001) was significantly and positively associated with FEV 1, as well as with FVC (vegetables: P=0.001, whale and/or seal: P=0.002). Regular fruit intake was included in the statistical models; however, it did not reach statistical significance (FEV 1: P=0.053; FVC: P=0.055).Conclusions:High dietary intake of vegetables as well as intake of arctic marine mammals had independent positive associations with lung function in this cohort of Greenlandic Inuit. These findings suggest an additive role of dietary intake of antioxidants and unsaturated fatty acids in lung health, which warrants prospective evaluation.

DOI 10.1038/ejcn.2015.85
Citations Scopus - 2
Co-authors Katherine Baines
2015 Fu J-J, McDonald VM, Baines KJ, Gibson PG, 'Airway IL-1 beta and Systemic Inflammation as Predictors of Future Exacerbation Risk in Asthma and COPD', CHEST, 148 618-629 (2015) [C1]
DOI 10.1378/chest.14-2337
Citations Scopus - 8
Co-authors Katherine Baines, Vanessa Mcdonald
2015 Powell H, Murphy VE, Hensley MJ, Giles W, Clifton VL, Gibson PG, 'Rhinitis in pregnant women with asthma is associated with poorer asthma control and quality of life', Journal of Asthma, (2015) [C1]

© 2015 Taylor & Francis. Objective: To describe the pattern and severity of rhinitis in pregnancy and the impact rhinitis has on asthma control and quality of life (QoL) in pregn... [more]

© 2015 Taylor & Francis. Objective: To describe the pattern and severity of rhinitis in pregnancy and the impact rhinitis has on asthma control and quality of life (QoL) in pregnant women with asthma. Methods: Two hundred and eighteen non-smoking pregnant women with asthma were participants in a randomised controlled trial of exhaled nitric oxide guided treatment adjustment. Rhinitis was assessed using a visual analogue scale (VAS) scored from 0 to 10 and classified as current (VAS¿>¿2.5), moderate/severe versus mild (VAS¿>¿6 vs <5), atopic versus non-atopic and pregnancy rhinitis. At baseline, women completed the 20-Item Sino-Nasal Outcome Test (SNOT20), asthma-specific (AQLQ-M) QoL questionnaires and the Six-Item Short-Form State Trait Anxiety Inventory (STAI-6). Asthma control was assessed using the asthma control questionnaire (ACQ). Perinatal outcomes were collected after delivery. Results: Current rhinitis was present in 142 (65%) women including 45 (20%) women who developed pregnancy rhinitis. Women with current rhinitis had higher scores for ACQ (p¿=¿0.004), SNOT20 (p¿<¿0.0001) and AQLQ-M (p¿<¿0.0001) compared to women with no rhinitis. Current rhinitis was associated with increased anxiety symptoms (p¿=¿0.002), rhinitis severity was associated with higher ACQ score (p¿=¿0.004) and atopic rhinitis was associated with poorer lung function (p¿=¿0.037). Rhinitis symptom severity improved significantly during gestation (p¿<¿0.0001). There was no impact on perinatal outcomes. Improved asthma control was associated with improvement in rhinitis. Conclusion: Rhinitis in pregnant women with asthma is common and associated with poorer asthma control, sino-nasal and asthma-specific QoL impairment and anxiety. In the context of active asthma management there was significant improvement in rhinitis symptoms and severity as pregnancy progressed.

DOI 10.3109/02770903.2015.1054403
Co-authors Michael Hensley, Vanessa Murphy
2015 Burgess L, McCaffery K, Powell H, Murphy VE, Gibson PG, Turner RM, 'The influence of asthma control on psychosocial outcomes for pregnant women with asthma', Journal of Asthma, (2015) [C1]

© 2015 Taylor & Francis. Objective: To investigate the relationship between asthma control and psychosocial outcomes in pregnant women with asthma. Methods: Secondary analysis (N... [more]

© 2015 Taylor & Francis. Objective: To investigate the relationship between asthma control and psychosocial outcomes in pregnant women with asthma. Methods: Secondary analysis (N¿=¿221) of a randomized controlled trial of treatment adjustments, based on fractional exhaled nitric oxide versus clinical guideline-based algorithms. Psychosocial variables included generic and asthma-specific quality of life (SF12, AQLQ-M), illness perceptions (BIPQ), perceived control (PCAQ), perceived risk of side effects (PRSE) and anxiety (STAI-6). Asthma control was defined as controlled (Asthma Control Questionnaire (ACQ7)¿=1.5 at randomization and end of study), improved (ACQ7¿>¿1.5 at randomization and =1.5 at end of study) and unimproved (ACQ7¿>1.5 at end of study). Regression models were fitted for each psychosocial measure at the end of the study, with adjustment for baseline values and smoking status, with predictor variable asthma control. Results: Women with unimproved asthma had poorer physical (SF12, p¿=¿0.012) and asthma-specific quality of life across all domains (AQLQ-M, p¿=¿0.012) compared to women with controlled asthma. They believed that they had less control over their asthma (PCAQ total p¿=¿0.014), had more symptoms and that their illness had a greater effect on their emotions and their lives in general (BIPQ identity, consequences, concern, emotional response p¿=¿0.015). Women with improved asthma control had significantly lower AQLQ-M breathlessness (p¿=¿0.048) and lower total scores (p¿=¿0.04) than women with controlled asthma. Conclusions: Pregnant women who are not able to get control of their asthma symptoms may experience worse quality of life and are likely to have more negative perceptions about their condition.

DOI 10.3109/02770903.2015.1038833
Co-authors Vanessa Murphy
2015 Gibson PG, Vertigan AE, 'Gabapentin in chronic cough', PULMONARY PHARMACOLOGY & THERAPEUTICS, 35 145-148 (2015) [C1]
DOI 10.1016/j.pupt.2015.06.007
Citations Scopus - 1
2015 Negewo NA, Gibson PG, McDonald VM, 'COPD and its comorbidities: Impact, measurement and mechanisms', RESPIROLOGY, 20 1160-1171 (2015) [C1]
DOI 10.1111/resp.12642
Citations Scopus - 4
Co-authors Vanessa Mcdonald
2015 Gibson PG, Vertigan AE, 'Management of chronic refractory cough.', BMJ, 351 h5590 (2015) [C1]
Citations Scopus - 1
2015 Chang AB, Grimwood K, Gibson PG, Upham JW, 'PBB: Definition, mechanisms, and treatment', The Lancet Respiratory Medicine, (2015) [C3]
DOI 10.1016/S2213-2600(15)00243-X
Citations Scopus - 1
2015 Scott HA, Gibson PG, Garg ML, Pretto JJ, Morgan PJ, Callister R, Wood LG, 'Determinants of weight loss success utilizing a meal replacement plan and/or exercise, in overweight and obese adults with asthma', Respirology, 20 243-250 (2015) [C1]

© 2014 Asian Pacific Society of Respirology.Background and objective While weight loss has been shown to reduce obesity-related comorbidity, many weight loss treatments fail. Fac... [more]

© 2014 Asian Pacific Society of Respirology.Background and objective While weight loss has been shown to reduce obesity-related comorbidity, many weight loss treatments fail. Factors that enhance weight loss success are unknown, particularly in those with asthma. The aim of the study was to identify patient characteristics that predict weight loss success in adults with asthma. Methods Baseline and change in asthma characteristics and eating behaviours were investigated for relationships with weight loss and fat loss using multiple linear regression, in 38 overweight and obese adults with asthma randomized to dietary, exercise or combined interventions targeting weight loss for 10 weeks. Results Mean ± standard deviation weight loss was 6.6 ± 5.1 kg. Greater %weight loss and %fat loss was achieved in those with poorer asthma-related quality of life at baseline ((rs = 0.398, P = 0.015) and (rs = 0.455, P = 0.005) respectively), with 1.7% greater absolute weight loss at week 10 corresponding to each one unit reduction in the asthma-related quality of life score at baseline. Furthermore, a lower baseline forced expiratory volume in 1 s/forced vital capacity correlated with greater weight loss (rs = 0.398, P = 0.015). Male sex was associated with a 3.6 kg greater weight loss (P = 0.087). Reducing emotional eating during the programme was associated with greater weight loss in women (rs = 0.576, P = 0.010). Conclusions This study demonstrates that individuals with more severe asthma at baseline are more successful in achieving weight loss, which could be a consequence of greater motivation and could be used as a motivational tool within the clinical setting. Gender tailoring of weight loss programmes may be useful to enhance weight loss success. Future studies are urgently needed to establish predictors of long-term weight loss maintenance in those with asthma. See Editorial, page 179 This study is the first to demonstrate that more severe asthma at baseline, male sex, and improvements in eating behaviours during weight loss are associated with greater weight loss success in overweight and obese adults with asthma. Our findings may inform the development of asthma-specific weight management guidelines.

DOI 10.1111/resp.12423
Citations Scopus - 3Web of Science - 1
Co-authors Philip Morgan, Robin Callister, Lisa Wood, Manohar Garg, Hayley Scott
2015 Mandaliya PH, Morten M, Kumar R, James A, Deshpande A, Murphy VE, et al., 'Ventilation inhomogeneities in children with congenital thoracic malformations', BMC Pulmonary Medicine, 15 (2015) [C1]

© Morten et al.; licensee BioMed Central.Background: Congenital thoracic malformations (CTM) are rare lung lesions that are managed with surgical resection or active surveillance... [more]

© Morten et al.; licensee BioMed Central.Background: Congenital thoracic malformations (CTM) are rare lung lesions that are managed with surgical resection or active surveillance. Methods: Nitrogen lung clearance index (LCI), reactance and resistance (X5Hz and R5Hz), forced expiratory volume in 1 s and forced vital capacity (FEV1 and FVC) were prospectively measured in 10 children with CTM (mean age/SD: 7.6/1.3) who had undergone surgical resection in early life and in 17 healthy children (mean age/SD: 4.8/0.4). Total lung capacity (TLC) was also conducted in children older than 7 years of age with CTM (n = 8). Results: Mean LCI was 8.0 (95% CI 7.5 to 8.5) in the CTM group and 7.3 (95% CI 7.0 to 7.6) in healthy children (p = 0.016). Mean X5Hz was -0.44kPa/l/s (95% CI -0.58 to -0.31) in the CTM group and -0.31kPa/l/s (95% CI -0.35 to -0.27) in healthy children (p = 0.02). Mean Z score for X5Hz was -2.11 (95% CI -3.59 to -0.63) in the CTM group and -0.11 (95% CI -0.55 to 0.33) in healthy children (p = 0.0008). Mean FEV1 was 1.21 L (95% CI 0.97 to 1.45) in the CTM group and 1.02 L (95% CI 0.90 to 1.15) in healthy children (p = 0.22). Mean % predicted FEV1 was 83% (95% CI 74 to 92) in the CTM group and 97% (95% CI 87 to 107) in healthy children (p < 0.05). Mean % predicted TLC in CTM children was 121.3% (95% CI 88.45 to 154.1). Mean LCI was inversely correlated with height z-scores in the CTM group (rs = -0.88, p = 0.002) but not in healthy children (rs = 0.22, p = 0.4). Conclusions: Children with CTM have impaired lung function as demonstrated by the significant differences in LCI, reactance and FEV1 but not FVC, resistance and TLC. These findings may be of clinical relevance as ventilation inhomogeneities are closely correlated with somatic growth in this study.

DOI 10.1186/s12890-015-0023-1
Co-authors Vanessa Murphy, Joerg Mattes
2015 Backer V, Baines KJ, Powell H, Porsbjerg C, Gibson PG, 'Increased asthma and adipose tissue inflammatory gene expression with obesity and Inuit migration to a western country', Respiratory Medicine, (2015)

© 2015 Elsevier Ltd. Background: An overlap between obesity and asthma exists, and inflammatory cells in adipose tissue could drive the development of asthma. Comparison of adipo... [more]

© 2015 Elsevier Ltd. Background: An overlap between obesity and asthma exists, and inflammatory cells in adipose tissue could drive the development of asthma. Comparison of adipose tissue gene expression among Inuit living in Greenland to those in Denmark provides an opportunity to assess how changes in adipose tissue inflammation can be modified by migration and diet. Objective: To examine mast cell and inflammatory markers in adipose tissue and the association with asthma. Methods: Two Inuit populations were recruited, one living in Greenland and another in Denmark. All underwent adipose subcutaneous biopsy, followed by clinical assessment of asthma, and measurement of AHR. Adipose tissue biopsies were homogenised, RNA extracted, and PCR was performed to determine the relative gene expression of mast cell (tryptase, chymase, CPA3) and inflammatory markers (IL-6, IL-1ß, and CD163). Results: Of the 1059 Greenlandic Inuit participants, 556 were living in Greenland and 6.4% had asthma. Asthma was increased in Denmark (9%) compared to Greenland (3.6%, p < 0.0001) and associated with increased adipose tissue IL-6 gene expression and increased BMI. There was no association between asthma and adipose tissue mast cell gene expression. Pro-inflammatory gene expression (IL-6, IL-1ß) was higher in those living in Denmark, and with increasing BMI and dietary changes. The anti-inflammatory (M2) macrophage marker, CD163, was higher in Greenland-dwelling Inuit (p < 0.01). Conclusions: No association was found between gene expression of mast cell markers in adipose tissue and asthma. Among Greenlandic Inuit, adipose tissue inflammation is also increased in those who migrate to Denmark, possibly as a result of dietary changes.

DOI 10.1016/j.rmed.2015.12.003
Co-authors Katherine Baines
2015 Gao P, Gibson PG, Baines KJ, Yang IA, Upham JW, Reynolds PN, et al., 'Anti-inflammatory deficiencies in neutrophilic asthma: Reduced galectin-3 and IL-1RA/IL-1ß', Respiratory Research, 16 1-10 (2015) [C1]
DOI 10.1186/s12931-014-0163-5
Citations Scopus - 5
Co-authors Jodie Simpson, Katherine Baines
2015 Gibson PG, McDonald VM, 'Asthma-COPD overlap 2015: Now we are six', Thorax, 70 683-691 (2015) [C1]

Background: The overlap between asthma and COPD is increasingly recognised. This review examines the new insights, treatment and remaining knowledge gaps for asthma-COPD overlap. ... [more]

Background: The overlap between asthma and COPD is increasingly recognised. This review examines the new insights, treatment and remaining knowledge gaps for asthma-COPD overlap. Method: A systematic literature review of cluster analyses of asthma and COPD was performed. Articles from 2009 to the present dealing with prevalence, morbidity and treatment of asthma-COPD overlap were identified and reviewed. Results: Asthma-COPD overlap was consistently recognised in studies using a variety of different study designs and sampling. The prevalence was approximately 20% in patients with obstructive airways diseases. Asthma-COPD overlap was associated with increased morbidity and possibly an increased mortality and comorbidity. There was evidence of a heterogeneous pattern of airway inflammation that included eosinophilic (in adult asthma), neutrophilic or mixed patterns (in severe asthma and COPD). Systemic inflammation was present in asthma-COPD overlap and resembled that of COPD. Within asthma-COPD overlap, there is evidence of different subgroups, and recognition using bronchodilator responsiveness has not been successful. Guidelines generally recommend a serial approach to assessment, with treatment recommendations dominated by an asthma paradigm. Research is needed into key clinical features that impact outcome, mechanisms and treatment approaches in asthma-COPD overlap. Identifying and treating disease components by multidimensional assessment shows promise. Conclusions: Asthma-COPD overlap has drawn attention to the significant heterogeneity that exists within obstructive airway diseases. It should be replaced by novel approaches that identify and manage the components of this heterogeneity, such as multidimensional assessment and treatment. Future research is needed to test these novel and personalised approaches.

DOI 10.1136/thoraxjnl-2014-206740
Citations Scopus - 12Web of Science - 3
Co-authors Vanessa Mcdonald
2015 Baines KJ, Wright TK, Simpson JL, McDonald VM, Wood LG, Parsons KS, et al., 'Airway beta-Defensin-1 Protein Is Elevated in COPD and Severe Asthma', MEDIATORS OF INFLAMMATION, (2015) [C1]
DOI 10.1155/2015/407271
Citations Scopus - 2
Co-authors Jodie Simpson, Katherine Baines, Vanessa Mcdonald, Peter Wark, Lisa Wood
2015 Kim RY, Pinkerton JW, Gibson PG, Cooper MA, Horvat JC, Hansbro PM, 'Inflammasomes in COPD and neutrophilic asthma', THORAX, 70 1199-1201 (2015) [C1]
DOI 10.1136/thoraxjnl-2014-206736
Citations Scopus - 1
Co-authors Philip Hansbro, Jay Horvat
2015 Wood LG, Lagleva M, Shah S, Berthon BS, Galbraith S, Henry R, et al., 'Dietary changes in migrant adolescents with increasing length of stay in Australia and associated risk of wheeze - a retrospective, cross sectional study', BMC Pediatrics, 15 (2015) [C1]

© 2015 Wood et al.Background: Recent studies have reported that asthma prevalence increases on migration to Australia. We hypothesised that changes in dietary intake contribute t... [more]

© 2015 Wood et al.Background: Recent studies have reported that asthma prevalence increases on migration to Australia. We hypothesised that changes in dietary intake contribute to this phenomenon. The aim of this study was to assess dietary intake in relation to migration status, length of stay in Australia and the association with self-reported wheeze. Methods: Students (n = 144) in a multicultural high school in Western Sydney completed the asthma symptoms ISAAC video questionnaire (AVQ3.0), spirometry and allergy skin prick tests. A dietitian administered a'Food Frequency' and 'Food Habits' questionnaire and a dietary history interview. Results: Students who spoke a language other than English, consumed a traditional or mixed dietary pattern, with lower consumption of saturated fat, compared to students who spoke English only. Saturated fat intake increased and fibre intake decreased with length of time in Australia. Intake of foods high in saturated or trans fatty acids were positively associated with length of stay in Australia. No associations between nutrient intake or whole food intake and self-reported wheeze were observed. Conclusion: As time progressed, dietary intake of immigrant children changed. While this was not associated with the development of wheeze in the students in this cohort, these changes are likely to have negative health consequences.

DOI 10.1186/s12887-015-0420-x
Co-authors Lisa Wood
2014 Gibson PG, Foster PS, 'Asthma 2014: from monoclonals to the microbiome.', Lancet Respir Med, 2 956-958 (2014) [C3]
DOI 10.1016/S2213-2600(14)70275-9
Co-authors Paul Foster
2014 Fu J-J, Mcdonald VM, Wang G, Gibson PG, 'Asthma control: How it can be best assessed?', Current Opinion in Pulmonary Medicine, 20 1-7 (2014) [C1]
DOI 10.1097/MCP.0000000000000003
Citations Scopus - 3Web of Science - 1
Co-authors Vanessa Mcdonald
2014 Mattes J, Gibson PG, 'The early origins of copd in severe asthma: The one thing that leads to another or the two things that come together?', Thorax, 69 789-790 (2014) [C3]
DOI 10.1136/thoraxjnl-2013-204815
Citations Scopus - 4Web of Science - 3
Co-authors Joerg Mattes
2014 Baines KJ, Upham JW, Yerkovich ST, Chang AB, Marchant JM, Carroll M, et al., 'Mediators of neutrophil function in children with protracted bacterial bronchitis', Chest, 146 1013-1020 (2014) [C1]

© 2014 American College of Chest Physicians.BACKGROUND: Protracted bacterial bronchitis (PBB) is a common and treatable cause of chronic wet cough in children in which the mechan... [more]

© 2014 American College of Chest Physicians.BACKGROUND: Protracted bacterial bronchitis (PBB) is a common and treatable cause of chronic wet cough in children in which the mechanisms are not understood. Th is study investigates the IL-1 pathway and a neutrophil gene expression signature in PBB.METHODS: BAL was collected from children in an experimental cohort (n = 21, PBB; n = 33, control subjects), and a second validation cohort (n = 36, PBB; n = 11, control subjects). IL-1ß , IL-1 receptor antagonist (IL-1RA), and a -defensins 1-3 were assayed by enzyme-linked immunosorbent assay, western blot, and quantitative real-time polymerase chain reaction, together with selected IL-1 pathway members and neutrophil-related molecules.RESULTS: In the experimental cohort, children with symptomatic PBB had significantly higher levels of IL-1ß and a -defensin gene and protein expression. Expression of the neutrophil chemokine receptor C-X-C motif receptor 2 was also higher in PBB. IL-1RA protein was higher, however, the IL-1RA:IL-1ß ratio was lower in children with PBB than control subjects. In the validation cohort, protein and gene expression of IL-1ß and a -defensins 1-3 were confirmed higher, as was gene expression of IL-1 pathway members and C-X-C motif receptor 2. IL-1ß and a -defensin 1-3 levels lowered when PBB was treated and resolved. In children with recurrent PBB, gene expression of the IL-1ß signaling molecules pellino-1 and IL-1 receptor-associated kinase 2 was significantly higher. IL-1ß protein levels correlated with BAL neutrophilia and the duration and severity of cough symptoms. IL-1ß and a -defensin 1-3 levels were highly correlated.CONCLUSIONS: PBB is characterized by increased IL-1ß pathway activation. IL-1ß and related mediators were associated with BAL neutrophils, cough symptoms, and disease recurrence, providing insight into PBB pathogenesis.

DOI 10.1378/chest.14-0131
Citations Scopus - 9Web of Science - 3
Co-authors Jodie Simpson, Katherine Baines
2014 Gunawardhana LP, Gibson PG, Simpson JL, Benton MC, Lea RA, Baines KJ, 'Characteristic DNA methylation profiles in peripheral blood monocytes are associated with inflammatory phenotypes of asthma.', Epigenetics, 9 1302-1316 (2014) [C1]
DOI 10.4161/epi.33066
Citations Scopus - 9Web of Science - 5
Co-authors Jodie Simpson, Katherine Baines
2014 Baines KJ, Backer V, Gibson PG, Powel H, Porsbjerg CM, 'Impaired lung function is associated with systemic inflammation and macrophage activation.', The European Respiratory Journal, 45 557-559 (2014) [C1]
Citations Web of Science - 1
Co-authors Katherine Baines
2014 Fu JJ, Gibson PG, Simpson JL, McDonald VM, 'Longitudinal changes in clinical outcomes in older patients with asthma, COPD and asthma-COPD overlap syndrome', Respiration, 87 63-74 (2014) [C1]

Background: The progression of obstructive airway diseases (OADs) including asthma, chronic obstructive pulmonary disease (COPD) and asthma-COPD overlap syndrome in older adults i... [more]

Background: The progression of obstructive airway diseases (OADs) including asthma, chronic obstructive pulmonary disease (COPD) and asthma-COPD overlap syndrome in older adults is not well understood. Objective: To examine the prognosis of OADs and to identify potential determinants for longitudinal changes in clinical outcomes. Methods: We consecutively recruited 99 older adults (>55 years) with OADs who underwent a multidimensional assessment at baseline and 4 years which involved spirometry, 6-min walk distance (6MWD), assessments of health status (Saint George's Respiratory Questionnaire, SGRQ), comorbidity, and serum and sputum biomarkers. All-cause mortality and respiratory hospitalisation during the follow-up period were recorded. Clinical outcomes were compared between basal and final visits, and changes in clinical outcomes were compared among asthma, COPD and asthma-COPD overlap groups. Associations between clinical parameters, biomarkers and prognosis were examined. Results: After a median follow-up of 4.2 years, outcome data were available for 75 (75.8%) patients. There were 16 (16.2%) deaths. The BODE index predicted all-cause mortality in older people with OADs. While spirometry, 6MWD and SGRQ deteriorated significantly over the 4 years, there was significant heterogeneity in the longitudinal changes in these clinical outcomes. Participants with COPD had a significant decline in FEV1 (p = 0.003), SGRQ (p = 0.030) and 6MWD [decline of 75.5 (93.4) m, p = 0.024]. The change in 6MWD was lower in the asthma-COPD overlap group. Airflow reversibility was associated with a reduced decline in 6MWD. Conclusion: COPD patients had a poor prognosis compared with asthma and asthma-COPD overlap patients. The BODE index is a useful prognostic indicator in older adults with OADs. Both airway disease diagnosis and BODE index warrant specific attention in clinical practice. © 2013 S. Karger AG, Basel.

DOI 10.1159/000352053
Citations Scopus - 25Web of Science - 15
Co-authors Vanessa Mcdonald, Jodie Simpson
2014 Jensen ME, Gibson PG, Collins CE, Wood LG, 'Lean mass, not fat mass, is associated with lung function in male and female children with asthma', Pediatric Research, 75 93-98 (2014) [C1]

Background:Whether body composition is associated with lung function in asthmatic children has not been investigated. This study aimed to primarily investigate whether BMI z-score... [more]

Background:Whether body composition is associated with lung function in asthmatic children has not been investigated. This study aimed to primarily investigate whether BMI z-score and body composition were associated with respiratory function in asthmatic children.Methods:In a cross-sectional study, male (n = 27; mean age: 11.9 y (SD: 2.3)) and female (n = 21; mean age: 13.6 y (SD: 2.2)) asthmatic children underwent clinical assessment.Results:BMI z-score was associated with forced expiratory volume in 1 s (FEV 1; r = 0.458), forced vital capacity (FVC; r = 0.477), and total lung capacity (TLC; r = 0.451) in males only (P < 0.05). Total lean mass was associated with FEV 1 (r = 0.655), FVC (r = 0.562), and TLC (r = 0.635) in males, as was thoracic lean mass (FEV 1 (r = 0.573), FVC (r = 0.526), and TLC (r = 0.497); P < 0.05). TLC was associated with total (r = 0.522) and thoracic (r = 0.532) lean mass in females (P < 0.05). Fat mass was not associated with lung function in this group.Conclusion:Lean mass, not fat mass, is associated with lung function in children with asthma. The positive association between BMI z-score and respiratory function in male children is driven by lean mass. Although body weight can be easily monitored in the clinical setting, body composition can provide important information. Future research exploring lean mass and lung function associations could inform future interventions. Copyright © 2014 International Pediatric Research Foundation, Inc.

DOI 10.1038/pr.2013.181
Citations Scopus - 2Web of Science - 1
Co-authors Clare Collins, Lisa Wood
2014 Mattes J, Murphy VE, Powell H, Gibson PG, 'Prenatal origins of bronchiolitis: Protective effect of optimised asthma management during pregnancy', Thorax, 69 383-384 (2014) [C1]

Objective Maternal asthma is the most common chronic disease complicating pregnancy and is a risk factor for bronchiolitis in infancy. Recurrent episodes of bronchiolitis are stro... [more]

Objective Maternal asthma is the most common chronic disease complicating pregnancy and is a risk factor for bronchiolitis in infancy. Recurrent episodes of bronchiolitis are strongly associated with the development of childhood asthma. Methods We conducted a follow-up study of infants born to women with asthma who completed a double-blind randomised controlled trial during pregnancy. In this trial, pregnant women with asthma were assigned to treatment adjustment by an algorithm using clinical symptoms (clinical group) or the fraction of exhaled nitric oxide (FeNO group) and we showed that the FeNO group had significantly lower asthma exacerbation rates in pregnancy. Results 146 infants attended the 12-month follow-up visit. Infants born to mothers from the FeNO group were significantly less likely to have recurrent episodes of bronchiolitis in the first year of life (OR 0.08, 95% CI 0.01 to 0.62; p=0.016) as compared with the clinical group. Conclusions Optimised management of asthma during pregnancy may reduce recurrent episodes of bronchiolitis in infancy, which could potentially modulate the risk to develop or the severity of emerging childhood asthma.

DOI 10.1136/thoraxjnl-2013-203388
Citations Scopus - 8Web of Science - 3
Co-authors Vanessa Murphy, Joerg Mattes
2014 Simpson JL, Baines KJ, Ryan N, Gibson PG, 'Neutrophilic asthma is characterised by increased rhinosinusitis with sleep disturbance and GERD', Asian Pacific Journal of Allergy and Immunology, 32 66-74 (2014) [C1]

Background: Asthma is a heterogeneous inflammatory disease and eosinophilic, noneosinophilic and neutrophilic forms are recognised. While clinically similar to eosinophilic asthma... [more]

Background: Asthma is a heterogeneous inflammatory disease and eosinophilic, noneosinophilic and neutrophilic forms are recognised. While clinically similar to eosinophilic asthma, patients with non-eosinophilic asthma have different responses to treatment and little is known about the triggers of symptoms and inflammation. Objective: This study sought to characterise asthma control, exacerbation frequency and potential triggers of non-eosinophilic and specifically neutrophilic asthma such as infection, gastroesophageal reflux disease, and rhinosinusitis. Methods: Adults with asthma (n=65; doctor's diagnosis plus demonstrated response to bronchodilator and/or airways hyperresponsiveness to hypertonic saline) were recruited from the Respiratory and Sleep Medicine Ambulatory Care Service at John Hunter Hospital, NSW, Australia. Questionnaires were administered to assess gastroesophageal reflux disease, rhinosinusitis and asthma control. A sputum induction was performed and sputum was processed for assessment of inflammatory cells, infection, and lipid laden macrophages (Oil Red O). Results: Participants with neutrophilic asthma (n=11, 23%) had a higher frequency of primary care doctor visits for asthma exacerbations and a high prevalence (>70%) of chest infections in the previous 12 months. There was also an increased prevalence of rhinosinusitis (64%) and increased symptoms of gastroesophageal reflux disease compared to those with eosinophilic asthma. Conclusions: The clinical pattern of neutrophilic asthma is different from paucigranulocytic and eosinophilic asthma with evidence of abnormal upper airways responses. Specific and targeted treatment of these airway problems may assist in the control and management of neutrophilic asthma.

DOI 10.12932/AP0322.32.1.2014
Citations Scopus - 4Web of Science - 1
Co-authors Katherine Baines, Jodie Simpson, Nicole Ryan
2014 Ortega HG, Liu MC, Pavord ID, Brusselle GG, FitzGerald JM, Chetta A, et al., 'Mepolizumab Treatment in Patients with Severe Eosinophilic Asthma', New England Journal of Medicine, 371 1198-1207 (2014)
DOI 10.1056/NEJMoa1403290
2014 Bel EH, Wenzel SE, Thompson PJ, Prazma CM, Keene ON, Yancey SW, et al., 'Oral Glucocorticoid-Sparing Effect of Mepolizumab in Eosinophilic Asthma', New England Journal of Medicine, 371 1189-1197 (2014)
DOI 10.1056/NEJMoa1403291
2014 Chung KF, Wenzel SE, Brozek JL, Bush A, Castro M, Sterk PJ, et al., 'International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma', EUROPEAN RESPIRATORY JOURNAL, 43 343-373 (2014) [C1]
DOI 10.1183/09031936.00202013
Citations Scopus - 282Web of Science - 125
2014 Simpson JL, Phipps S, Baines KJ, Oreo KM, Gunawardhana L, Gibson PG, 'Elevated expression of the NLRP3 inflammasome in neutrophilic asthma', European Respiratory Journal, 43 1067-1076 (2014) [C1]

Asthma is a heterogeneous inflammatory airways disorder where interleukin (IL)-1ß is thought to be a key mediator, especially in the neutrophilic subtype of asthma. The generatio... [more]

Asthma is a heterogeneous inflammatory airways disorder where interleukin (IL)-1ß is thought to be a key mediator, especially in the neutrophilic subtype of asthma. The generation of active IL-1ß requires proteolytic cleavage typically mediated through the formation of a caspase-1-containing inflammasome. This study hypothesised that an IL-1ß endotype associated with the nucleotide-binding domain, leucine-rich repeat-containing family protein (NLRP)3/apoptosis-associated speck-like protein containing a caspase-recruitment domain (ASC)/caspase-1 inflammasome is characteristic of patients with the neutrophilic subtype of asthma. Participants with asthma (n=85) and healthy controls (n=27) underwent clinical assessment, spirometry and sputum induction. Sputum was processed for differential cell count, gene expression and protein mediators. NLRP3 and caspase-1 expression was also determined by immunocytochemistry. Sputum macrophages were isolated (n=8) and gene expression of NLRP3 and IL-1ß determined. There was significantly elevated gene expression of NLRP3, caspase-1, caspase-4, caspase-5 and IL-1ß in participants with neutrophilic asthma. Protein levels of IL-1ß were significantly higher in those with neutrophilic asthma and correlated with sputum IL-8 levels. Sputum macrophages, as well as sputum neutrophils in neutrophilic asthma, expressed NLRP3 and caspase-1 protein. NLRP3 inflammasome is upregulated in neutrophilic asthma and may regulate the inflammation process observed in this asthma phenotype through production of IL-1ß. Copyright © ERS 2014.

DOI 10.1183/09031936.00105013
Citations Scopus - 21Web of Science - 11
Co-authors Jodie Simpson, Katherine Baines
2014 Murphy VE, Mattes J, Powell H, Baines KJ, Gibson PG, 'Respiratory viral infections in pregnant women with asthma are associated with wheezing in the first 12 months of life', Pediatric Allergy and Immunology, 25 151-158 (2014) [C1]

Background: There are few studies investigating the relationship between respiratory viral infection in pregnancy and asthma in the offspring, and none among mothers with asthma. ... [more]

Background: There are few studies investigating the relationship between respiratory viral infection in pregnancy and asthma in the offspring, and none among mothers with asthma. Infants of mothers with asthma are more likely to wheeze and have a higher risk of developing asthma than infants of non-asthmatic mothers. Methods: A prospective cohort study of viral infection in pregnancy was conducted between 2007 and 2009, and a subgroup of infants of mothers with asthma was followed up at 6 and 12 months of age. During common colds, nasal and throat swabs were collected from mothers and respiratory viruses detected by polymerase chain reaction. Respiratory health of infants was assessed by parent-completed questionnaire. Results: Twelve-month-old infants whose mothers had confirmed viral infections in pregnancy (n = 26) reported more frequent wheeze (40% had 4-12 wheeze attacks compared with 0%), sleep disturbed by wheeze (1 night per week or more in 60% vs. 11%), beta agonist treatment for wheeze (27% vs. 0%), prolonged colds (2 wk or longer 31% vs. 0%), more eczema (40% vs. 6.3%), and parent-perceived asthma (32% vs. 0%), compared with infants whose mothers had common colds without laboratory-confirmed viral infection (n = 16). Conclusions: This study demonstrates a relationship between maternal respiratory viral infection in pregnancy and wheezing illness in infants of mothers with asthma. Viral infections are the most common cause of asthma exacerbations in pregnancy, and infants of asthmatic mothers are at increased risk of asthma themselves. Further research is needed to elucidate the mechanisms involved. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

DOI 10.1111/pai.12156
Citations Scopus - 5Web of Science - 2
Co-authors Joerg Mattes, Katherine Baines, Vanessa Murphy
2014 Oreo KM, Gibson PG, Simpson JL, Wood LG, Mcdonald VM, Baines KJ, 'Sputum ADAM8 expression is increased in severe asthma and COPD', Clinical and Experimental Allergy, 44 342-352 (2014) [C1]

Background: Severe asthma and chronic obstructive pulmonary disease (COPD) are chronic inflammatory airway diseases in which the mechanisms are not fully understood. A disintegrin... [more]

Background: Severe asthma and chronic obstructive pulmonary disease (COPD) are chronic inflammatory airway diseases in which the mechanisms are not fully understood. A disintegrin and metalloproteinase domain 8 (ADAM8) is an enzyme expressed on most leucocytes and may be important for facilitating leucocyte migration in respiratory disease. Objective: To investigate ADAM8 mRNA and protein expression in asthma and COPD and its relationship between asthma severity and inflammatory phenotypes. Methods: Induced sputum was collected from 113 subjects with asthma (severe n = 31, uncontrolled n = 39 and controlled n = 35), 20 subjects with COPD and 21 healthy controls. Sputum ADAM8 mRNA expression was measured by qPCR, and soluble ADAM8 (sADAM8) protein was measured in the sputum supernatant by validated ELISA. Results: ADAM8 mRNA correlated with ADAM8 protein levels (r = 0.27, P < 0.01). ADAM8 mRNA (P = 0.004) and sADAM8 protein (P = 0.014) levels were significantly higher in both asthma and COPD compared with healthy controls. ADAM8 mRNA (P = 0.035) and sADAM8 protein (P = 0.002) levels were significantly higher in severe asthma compared with controlled asthma. Total inflammatory cell count (P < 0.01) and neutrophils (P < 0.01) were also elevated in severe asthmatic sputum. Although ADAM8 mRNA was significantly higher in eosinophilic and neutrophilic asthma (P < 0.001), sADAM8 did not differ between asthma inflammatory phenotypes. ADAM8 expression positively correlated with sputum total cell count and sputum neutrophils. Conclusions and Clinical Relevance: ADAM8 expression is increased in both severe asthma and COPD and associated with sputum total cell count and neutrophils. ADAM8 may facilitate neutrophil migration to the airways in severe asthma and COPD. © 2013 John Wiley & Sons Ltd.

DOI 10.1111/cea.12223
Citations Scopus - 6Web of Science - 2
Co-authors Vanessa Mcdonald, Katherine Baines, Jodie Simpson, Lisa Wood
2014 Zhang XY, Simpson JL, Powell H, Yang IA, Upham JW, Reynolds PN, et al., 'Full blood count parameters for the detection of asthma inflammatory phenotypes', Clinical and Experimental Allergy, 44 1137-1145 (2014) [C1]

Summary: Background: In asthma, the airway inflammatory phenotype influences clinical characteristics and treatment response. Although induced sputum is the gold standard test for... [more]

Summary: Background: In asthma, the airway inflammatory phenotype influences clinical characteristics and treatment response. Although induced sputum is the gold standard test for phenotyping asthma, a more accessible method is needed for clinical practice. Objective: To investigate whether white blood cell counts and/or their derived ratios can predict sputum eosinophils or neutrophils in uncontrolled asthma. Methods: This cross-sectional study evaluated 164 treated but uncontrolled asthmatic patients with sputum induction and blood collection. Receiver-operating characteristic (ROC) curves were used to assess the relationship between blood and sputum parameters. Results: There was a significant positive relationship between blood eosinophil parameters and the percentage of sputum eosinophil count. A weak but significant correlation was found between sputum neutrophil percentage and blood neutrophil percentage (r = 0.219, P = 0.005). ROC curve analysis identified that blood eosinophil percentage count was the best predictor for eosinophilic asthma, with an area under the curve (AUC) of 0.907 (P < 0.001). The optimum cut-point for blood eosinophil percentage was 2.7%, and this yielded a sensitivity of 92.2% and a specificity of 75.8%. The absolute blood eosinophil count was also highly predictive with an AUC of 0.898 (P < 0.0001) at a blood eosinophil cut-off of 0.26 × 109/L. The blood eosinophil/lymphocyte ratio (ELR) and eosinophil/neutrophil ratio (ENR) were increased in eosinophilic asthma, and the neutrophil/lymphocyte ratio (NLR) was increased in neutrophilic asthma. Neutrophilic asthma could also be detected by blood neutrophil percentages and NLR, but with less accuracy. Conclusions and Clinical Relevance: Blood eosinophil counts and derived ratios (ELR and ENR) can accurately predict eosinophilic asthma in patients with persistent uncontrolled asthma despite treatment. Blood neutrophil parameters are poor surrogates for the proportion of sputum neutrophils. Blood counts may be a useful aid in the monitoring of uncontrolled asthma. © 2014 John Wiley & Sons Ltd.

DOI 10.1111/cea.12345
Citations Scopus - 16Web of Science - 7
Co-authors Jodie Simpson
2014 Zhang HP, Jia CE, Lv Y, Gibson PG, Wang G, 'Montelukast for prevention and treatment of asthma exacerbations in adults: Systematic review and meta-analysis', Allergy and Asthma Proceedings, 35 278-287 (2014) [C1]

It has proven efficacy in reducing asthma exacerbations, but the effect size of montelukast (a leukotriene receptor antagonist) for varied severity of asthma exacerbations is not ... [more]

It has proven efficacy in reducing asthma exacerbations, but the effect size of montelukast (a leukotriene receptor antagonist) for varied severity of asthma exacerbations is not systematically assessed. This study was designed to systematically explore the evidence for montelukast, as first-line or add-on therapy, in preventing and treating asthma exacerbations in adult patients with asthma. Randomized controlled trials were searched in PubMed, CENTRAL, COPY Web of Science, Embase, and OVID up to March 2013, where montelukast prevented or treated asthma exacerbations in adults. Primary outcomes were the number of patients experiencing exacerbations in chronic asthma and hospitalizations in acute asthma. Odds ratio (OR) with 95% confidence intervals (CI), risk difference, and number needed to treat (NNT) were calculated and pooled. Adverse events were also assessed in chronic asthma. Twenty trials for chronic asthma and six for acute asthma were identified. In comparison with placebo, adults with chronic asthma receiving montelukast had significantly reduced number of exacerbations (OR = 0.60 and 95% CI, 0.49, 0.74; NNT = 17 and 95% CI, 12, 29). However, montelukast was inferior to inhaled corticosteroids (ICSs) (OR = 1.63; 95% CI, 1.29, 2.0) and ICS plus long-acting beta2-agonist (LABA; OR = 3.94; 95% CI, 1.64, 9.48) as the first-line therapies and LABA (OR = 1.22; 95% CI, 1.05, 1.42) as the add-on therapies in reducing asthma exacerbations. In acute asthma, montelukast could statistically improve peak expiratory flow percent predicted (p = 0.008) and reduce systemic corticosteroid intake (p = 0.005). Montelukast had low risk in hoarseness and insomnia. Our meta-analysis suggests that montelukast significantly reduces mild, moderate, and part of severe exacerbations in chronic mild to moderate asthma, but it has inferior efficacy to ICS or ICS plus LABA. Copyright © 2014, OceanSide Publications, Inc.

DOI 10.2500/aap.2014.35.3745
Citations Scopus - 6Web of Science - 4
2014 Simpson JL, Gibson PG, Yang IA, Upham J, James A, Reynolds PN, Hodge S, 'Altered sputum granzyme B and granzyme B/proteinase inhibitor-9 in patients with non-eosinophilic asthma', RESPIROLOGY, 19 280-287 (2014) [C1]
DOI 10.1111/resp.12213
Citations Scopus - 4Web of Science - 2
Co-authors Jodie Simpson
2014 Gibson P, 'Laryngeal botoxification for severe asthma', RESPIROLOGY, 19 467-468 (2014) [C3]
DOI 10.1111/resp.12278
Citations Scopus - 1Web of Science - 1
2014 Gunawardhana LP, Gibson PG, Simpson JL, Powell H, Baines KJ, 'Activity and expression of histone acetylases and deacetylases in inflammatory phenotypes of asthma', Clinical & Experimental Allergy, 44 47-57 (2014) [C1]
DOI 10.1111/cea.12168
Citations Scopus - 10Web of Science - 3
Co-authors Jodie Simpson, Katherine Baines
2014 Hodge S, Hodge G, Pizzutto S, Petsky H, Gibson P, Chang A, Upham J, 'REDUCED MACROPHAGE PHAGOCYTIC HOST RESPONSE TO NTHI IN CHILDREN WITH BRONCHIECTASIS', RESPIROLOGY, 19 86-86 (2014)
2014 Gibson PG, Simpson JL, Ryan NM, Vertigan AE, 'Mechanisms of cough', CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 14 55-61 (2014) [C1]
DOI 10.1097/ACI.0000000000000027
Citations Scopus - 8Web of Science - 5
Co-authors Jodie Simpson, Nicole Ryan
2014 Vertigan AE, Bone SL, Gibson PG, 'Development and validation of the Newcastle laryngeal hypersensitivity questionnaire', Acta Veterinaria Scandinavica, 10 1-13 (2014) [C1]
DOI 10.1186/1745-9974-10-1
Citations Scopus - 8
2014 Simpson JL, Powell H, Baines KJ, Milne D, Coxson HO, Hansbro PM, Gibson PG, 'The Effect of Azithromycin in Adults with Stable Neutrophilic COPD: A Double Blind Randomised, Placebo Controlled Trial', PLOS ONE, 9 (2014) [C1]
DOI 10.1371/journal.pone.0105609
Citations Scopus - 5Web of Science - 3
Co-authors Philip Hansbro, Jodie Simpson, Katherine Baines
2014 Baines KJ, Simpson JL, Wood LG, Scott RJ, Fibbens NL, Powell H, et al., 'Sputum gene expression signature of 6 biomarkers discriminates asthma inflammatory phenotypes', Journal of Allergy and Clinical Immunology, 133 997-1007 (2014) [C1]

Background Airway inflammation is associated with asthma exacerbation risk, treatment response, and disease mechanisms. Objective This study aimed to identify and validate a sputu... [more]

Background Airway inflammation is associated with asthma exacerbation risk, treatment response, and disease mechanisms. Objective This study aimed to identify and validate a sputum gene expression signature that discriminates asthma inflammatory phenotypes. Methods An asthma phenotype biomarker discovery study generated gene expression profiles from induced sputum of 47 asthmatic patients. A clinical validation study (n = 59 asthmatic patients) confirmed differential expression of key genes. A 6-gene signature was identified and evaluated for reproducibility (n = 30 asthmatic patients and n = 20 control subjects) and prediction of inhaled corticosteroid (ICS) response (n = 71 asthmatic patients). Receiver operating characteristic curves were calculated, and area under the curve (AUC) values were reported. Results From 277 differentially expressed genes between asthma inflammatory phenotypes, we identified 23 genes that showed highly significant differential expression in both the discovery and validation populations. A signature of 6 genes, including Charcot-Leydon crystal protein (CLC); carboxypeptidase A3 (CPA3); deoxyribonuclease I-like 3 (DNASE1L3); IL-1ß (IL1B); alkaline phosphatase, tissue-nonspecific isozyme (ALPL); and chemokine (C-X-C motif) receptor 2 (CXCR2), was reproducible and could significantly (P <.0001) discriminate eosinophilic asthma from other phenotypes, including patients with noneosinophilic asthma (AUC, 89.6%), paucigranulocytic asthma (AUC, 92.6%), or neutrophilic asthma (AUC, 91.4%) and healthy control subjects (AUC, 97.6%), as well as discriminating patients with neutrophilic asthma from those with paucigranulocytic asthma (AUC, 85.7%) and healthy control subjects (AUC, 90.8). The 6-gene signature predicted ICS response (>12% change in FEV1; AUC, 91.5%). ICS treatment reduced the expression of CLC, CPA3, and DNASE1L3 in patients with eosinophilic asthma. Conclusions A sputum gene expression signature of 6 biomarkers reproducibly and significantly discriminates inflammatory phenotypes of asthma and predicts ICS treatment response. This signature has the potential to become a useful diagnostic tool to assist in the clinical diagnosis and management of asthma. © 2013 American Academy of Allergy, Asthma & Immunology.

DOI 10.1016/j.jaci.2013.12.1091
Citations Scopus - 32Web of Science - 18
Co-authors Lisa Wood, Katherine Baines, Rodney Scott, Jodie Simpson
2014 Ryan NM, Gibson PG, 'Recent additions in the treatment of cough', JOURNAL OF THORACIC DISEASE, 6 S739-S747 (2014) [C1]
DOI 10.3978/j.issn.2072-1439.2014.03.13
Citations Web of Science - 1
Co-authors Nicole Ryan
2014 Ryan NM, Birring SS, Gibson PG, 'Arnold¿s nerve cough reflex: evidence for chronic cough as a sensory vagal neuropathy', Journal of Thoracic Disease, 6 S748-S752 (2014) [C3]
DOI 10.3978/j.issn.2072-1439.2014.04.22
Co-authors Nicole Ryan
2014 Fu JJ, McDonald VM, Gibson PG, Simpson JL, 'Systemic inflammation in older adults with asthma-COPD overlap syndrome', Allergy, Asthma and Immunology Research, 6 316-324 (2014) [C1]

Purpose: The role of systemic inflammation on asthma-COPD overlap syndrome is unknown. This study aimed to examine systemic inflammation in asthma-COPD overlap syndrome, and to id... [more]

Purpose: The role of systemic inflammation on asthma-COPD overlap syndrome is unknown. This study aimed to examine systemic inflammation in asthma-COPD overlap syndrome, and to identify associations between clinical characteristics and inflammatory mediators in asthma-COPD overlap syndrome. Methods: In 108 adults older than 55 years comprising healthy controls (n=29), asthma (n=16), COPD (n=21) and asthma-COPD overlap syndrome (n=42), serum high sensitivity C-reactive protein and Interleukin 6 (IL-6) were assayed. Spirometry, induced sputum, quality of life, comorbidities and medications were assessed, and their associations with asthma-COPD overlap syndrome were analyzed using logistic regression. Associations between systemic inflammatory mediators and clinical characteristics were tested in multivariate linear regression models. Results: Patients with asthma-COPD overlap syndrome had significantly elevated IL-6 levels compared with healthy controls and asthmatics. Age, comorbidity index and IL-6 level were independently associated with asthma-COPD overlap syndrome. FEV1% predicted was inversely associated with IL-6 level, and cardiovascular disease was associated with an increased IL-6 level. Systemic markers were not associated with airway inflammation. Conclusions: Systemic inflammation is commonly present in asthma-COPD overlap syndrome, and asthma-COPD overlap syndrome resembled COPD in terms of systemic inflammation. IL-6 is a pivotal inflammatory mediator that may be involved in airflow obstruction and cardiovascular disease and may be an independent treatment target. © Copyright The Korean Academy of Asthma, Allergy and Clinical Immunology.

DOI 10.4168/aair.2014.6.4.316
Citations Scopus - 21Web of Science - 12
Co-authors Jodie Simpson, Vanessa Mcdonald
2014 Gunawardhana LP, Baines KJ, Mattes J, Murphy VE, Simpson JL, Gibson PG, 'Differential DNA methylation profiles of infants exposed to maternal asthma during pregnancy', Pediatric Pulmonology, 49 852-862 (2014) [C1]

Background Asthma is a complex disease that involves both genetic factors and environmental exposures. Aberrant epigenetic modifications, such as DNA methylation, may be important... [more]

Background Asthma is a complex disease that involves both genetic factors and environmental exposures. Aberrant epigenetic modifications, such as DNA methylation, may be important in asthma development. Fetal exposure to maternal asthma during critical periods of in utero development may lead to epigenetic alterations that predispose infants to a greater risk of developing asthma themselves. We investigated alterations in the DNA methylation profile of peripheral blood from infants exposed to maternal asthma during pregnancy. Methods Peripheral blood was collected from 12-month-old infants born to women with (n = 25) and without (n = 15) doctor diagnosed asthma during pregnancy. Genomic DNA was extracted, bisulfite converted, and hybridized to Infinium Methylation 27 arrays (Illumina), containing over27,000 CpGs from 14,495 genes. CpG loci in only autosomal genes were classified as differentially methylated at the 99% level (P < 0.01, |DiffScore| > 22 and delta beta >0.06). Results There were 70 CpG loci, corresponding to 67 genes that were significantly differentially methylated. Twelve CpG loci (11 genes) showed greater than 10% comparative difference in DNA methylation, including hyper-methylated loci of FAM181A, MRI1, PIWIL1, CHFR, DEFA1, MRPL28, AURKA, and hypo-methylated loci of NALP1L5, MAP8KIP3, ACAT2, and PM20D1 in maternal asthma. Methylation of MAPK8IP3 was significantly negatively correlated with maternal blood eosinophils (r = -0.38; P = 0.022), maternal eNO (r = -0.44; P = 0.005), and maternal serum total IgE (r = -0.39, P = 0.015). Methylation of AURKA negatively correlated with maternal hemoglobin (r = -0.43; P = 0.008), infants height (r = -0.51; P < 0.001) and weight (r = -0.36; P = 0.021). Methylation of PM20D1 was lower in infants born to mothers with asthma on inhaled corticosteroid treatment. Methylation of PM20D1 was lower and MRI1 was higher in infants born to atopic mothers without asthma. Conclusions In an Australian study population, exposure to maternal asthma during pregnancy is associated with differential methylation profiles of infants' peripheral blood DNA, which may act as risk factors for future asthma development. © 2013 Wiley Periodicals, Inc.

DOI 10.1002/ppul.22930
Citations Scopus - 6Web of Science - 4
Co-authors Jodie Simpson, Joerg Mattes, Katherine Baines, Vanessa Murphy
2014 Walters JAE, Tan DJ, White CJ, Gibson PG, Wood-Baker R, Walters EH, 'Systemic corticosteroids for acute exacerbations of chronic obstructive pulmonary disease', COCHRANE DATABASE OF SYSTEMATIC REVIEWS, (2014) [C1]
DOI 10.1002/14651858.CD001288.pub4
Citations Web of Science - 1
2014 Simpson JL, Guest M, Boggess MM, Gibson PG, 'Occupational exposures, smoking and airway inflammation in refractory asthma', BMC PULMONARY MEDICINE, 14 (2014) [C1]
DOI 10.1186/1471-2466-14-207
Citations Scopus - 1
Co-authors Jodie Simpson
2014 Wang G, Murphy VE, Namazy J, Powell H, Schatz M, Chambers C, et al., 'The risk of maternal and placental complications in pregnant women with asthma: A systematic review and meta-analysis', Journal of Maternal-Fetal and Neonatal Medicine, 27 934-942 (2014) [C1]

Objective: To investigate if maternal asthma is associated with an increased risk of maternal and placental complications in pregnancy. Methods: Electronic databases were searched... [more]

Objective: To investigate if maternal asthma is associated with an increased risk of maternal and placental complications in pregnancy. Methods: Electronic databases were searched for the following terms: (asthma or wheeze) and (pregnan* or perinat* or obstet*). Cohort studies published between January 1975 and March 2012 were considered for inclusion. Forty publications met the inclusion criteria, reporting at least one maternal or placental complication in pregnant women with and without asthma. Relative risk (RR) with 95% confidence intervals (CIs) was calculated. Results: Maternal asthma was associated with a significantly increased risk of cesarean section (RR=1.31, 95%CI=[1.22-1.39]), gestational diabetes (RR=1.39, 95%CI=[1.17-1.66]), hemorrhage (antepartum: RR=1.25, 95%CI=[1.10-1.42]; postpartum: RR=1.29, 95%CI=[1.18-1.41]), placenta previa (RR=1.23, 95%CI=[1.07-1.40]), placental abruption (RR=1.29, 95%CI=[1.14-1.47]) and premature rupture of membranes (RR=1.21, 95%CI=1.07-1.37). Moderate to severe asthma significantly increased the risk of cesarean section (RR=1.19, 95%CI=[1.09-1.31]) and gestational diabetes (RR=1.19, 95%CI=[1.06-1.33]) compared to mild asthma. Bronchodilator use was associated with a significantly lowered risk of gestational diabetes (RR=0.64, 95%CI=[0.57-0.72]). Conclusions: Pregnant women with asthma are at increased risk of maternal and placental complications, and women with moderate/severe asthma may be at particular risk. Further studies are required to elucidate whether adequate control of asthma during pregnancy reduces these risks. © 2014 Informa UK Ltd. All rights reserved.

DOI 10.3109/14767058.2013.847080
Citations Scopus - 13Web of Science - 4
Co-authors Vanessa Murphy, John Attia
2014 Gibson PG, McDonald VM, 'Why is COPD phenotyping like sorting diamonds?', Eur Respir J, 44 277-279 (2014) [C3]
DOI 10.1183/09031936.00091214
Citations Scopus - 1Web of Science - 1
Co-authors Vanessa Mcdonald
2014 Baines KJ, Pavord ID, Gibson PG, 'The role of biomarkers in the management of airways disease.', Int J Tuberc Lung Dis, 18 1264-1268 (2014) [C1]
DOI 10.5588/ijtld.14.0226
Citations Scopus - 5Web of Science - 4
Co-authors Katherine Baines
2014 Negewo NA, McDonald VM, Gibson PG, 'Comorbidity in chronic obstructive pulmonary disease', Respiratory Investigation, (2014) [C1]

© 2015 The Japanese Respiratory Society. Patients with chronic obstructive pulmonary diseases (COPD) often experience comorbid conditions. The most common comorbidities that have... [more]

© 2015 The Japanese Respiratory Society. Patients with chronic obstructive pulmonary diseases (COPD) often experience comorbid conditions. The most common comorbidities that have been associated with COPD include cardiovascular diseases, lung cancer, metabolic disorder, osteoporosis, anxiety and depression, skeletal muscle dysfunction, cachexia, gastrointestinal diseases, and other respiratory conditions. Not only are comorbidities common but they also considerably influence disease prognosis and patients' health status, and are associated with poor clinical outcomes. However, perusal of literature indicates that little has been done so far to effectively assess, manage, and treat comorbidities in patients with COPD. The aim of this review is to comprehensively narrate the comorbid conditions that often coexist with COPD, along with their reported prevalence and their significant impacts in the disease management of COPD. A perspective on integrated disease management approaches for COPD is also discussed.

DOI 10.1016/j.resinv.2015.02.004
Citations Scopus - 3
Co-authors Vanessa Mcdonald
2013 Gibson PG, 'Induced Sputum', APSR Respiratory Updates, 5 1-7 (2013) [C3]
2013 Gibson PG, 'Obesity and asthma.', Ann Am Thorac Soc, 10 Suppl S138-S142 (2013) [C1]
DOI 10.1513/AnnalsATS.201302-038AW
Citations Scopus - 10
2013 Periyalil HA, Gibson PG, Wood LG, 'Immunometabolism in obese asthmatics: Are we there yet?', Nutrients, 5 3506-3530 (2013) [C1]

Obesity is now recognised as a worldwide epidemic. The recent International Association for the Study of Obesity/International Obesity Taskforce (IASO/IOTF) analysis estimates tha... [more]

Obesity is now recognised as a worldwide epidemic. The recent International Association for the Study of Obesity/International Obesity Taskforce (IASO/IOTF) analysis estimates that approximately 1.0 billion adults are currently overweight and a further 475 million are obese. Obesity has huge psychosocial impact with obese children and adolescents facing discrimination and stigmatization in many areas of their lives leading to body dissatisfaction, low self-esteem and depression. Indeed, obesity is recognised as an important risk factor for the development of several chronic diseases such as hypertension, cancer, asthma and metabolic syndrome. Chronic low grade systemic inflammation is considered as a hallmark of obesity and may possibly explain the link between obesity and chronic disease, in particular the increased incidence, prevalence and severity of asthma in obese individuals. There is now strong evidence for infiltration of immune and inflammatory cells into adipose tissue that drives systemic inflammation and subsequent end organ damage. In addition to adipocytes, the key adipose tissue resident immune cells are macrophages and mast cells. Immunometabolism, as an emerging field of investigation, explores the pivotal role of these immune cells in translating immunological changes to metabolic effects in obesity. Abundance of free fatty acids, along with other inflammatory cytokines shift the balance of metabolic homeostasis to pro-inflammatory status by influencing the development of inflammatory cell lineage, which, further exhibits distinct functional phenotypes. There is emerging evidence for macrophage activation and functional polarization of an anti-inflammatory M2 phenotype towards a pro-inflammatory M1 phenotype of macrophages in obese adipose tissue. Similarly, studies in both obese humans and murine models reveal the pathognomic presence of an increased number of mast cells in visceral adipose tissue. These suggest a possible contribution of mast cells to the unique metabolome of obese asthma. This review examines proposed multilevel interactions between metabolic and immune systems in obese asthmatics that underlie the negative effects of obesity and may offer significant therapeutic promise. © 2013 by the authors; licensee MDPI, Basel, Switzerland.

DOI 10.3390/nu5093506
Citations Scopus - 7Web of Science - 4
Co-authors Lisa Wood
2013 Murphy VE, Powell H, Wark PAB, Gibson PG, 'A Prospective Study of Respiratory Viral Infection in Pregnant Women With and Without Asthma', CHEST, 144 420-427 (2013) [C1]
DOI 10.1378/chest.12-1956
Citations Scopus - 7Web of Science - 3
Co-authors Peter Wark, Vanessa Murphy
2013 McDonald V, Wood L, Baines P, Higgins I, Gibson P, 'Obesity and bone health in COPD', EUROPEAN RESPIRATORY JOURNAL, 42 (2013)
Co-authors Isabel Higgins, Lisa Wood, Vanessa Mcdonald
2013 Thorburn AN, Brown AC, Nair PM, Chevalier N, Foster PS, Gibson PG, Hansbro PM, 'Pneumococcal Components Induce Regulatory T Cells That Attenuate the Development of Allergic Airways Disease by Deviating and Suppressing the Immune Response to Allergen', JOURNAL OF IMMUNOLOGY, 191 4112-4120 (2013) [C1]
DOI 10.4049/jimmunol.1201232
Citations Scopus - 6Web of Science - 4
Co-authors Paul Foster, Philip Hansbro
2013 Vanders RL, Gibson PG, Murphy VE, Wark PAB, 'Plasmacytoid Dendritic Cells and CD8 T Cells From PregnantWomen Show Altered Phenotype and Function Following H1N1/09 Infection', JOURNAL OF INFECTIOUS DISEASES, 208 1062-1070 (2013) [C1]
DOI 10.1093/infdis/jit296
Citations Scopus - 7Web of Science - 5
Co-authors Peter Wark, Vanessa Murphy
2013 Gibson PG, 'Macrolides for yet another chronic airway disease: severe asthma?', THORAX, 68 313-314 (2013) [C3]
DOI 10.1136/thoraxjnl-2012-203055
Citations Scopus - 2
2013 McDonald VM, Higgins I, Wood LG, Gibson PG, 'Multidimensional assessment and tailored interventions for COPD: respiratory utopia or common sense?', THORAX, 68 691-694 (2013) [C1]
DOI 10.1136/thoraxjnl-2012-202646
Citations Scopus - 34Web of Science - 18
Co-authors Lisa Wood, Vanessa Mcdonald, Isabel Higgins
2013 Jia CE, Zhang HP, Lv Y, Liang R, Jiang YQ, Powell H, et al., 'The Asthma Control Test and Asthma Control Questionnaire for assessing asthma control: Systematic review and meta-analysis', JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 131 695-703 (2013) [C1]
DOI 10.1016/j.jaci.2012.08.023
Citations Scopus - 47Web of Science - 34
2013 Ryan NM, Birring SS, Gibson PG, 'Gabapentin for refractory chronic cough Reply', LANCET, 381 624-625 (2013) [C3]
Citations Scopus - 2Web of Science - 2
Co-authors Nicole Ryan
2013 Powell H, McCaffery K, Murphy VE, Hensley MJ, Clifton VL, Giles W, Gibson PG, 'Psychosocial Variables Are Related to Future Exacerbation Risk and Perinatal Outcomes in Pregnant Women with Asthma', JOURNAL OF ASTHMA, 50 383-389 (2013) [C1]
DOI 10.3109/02770903.2012.757777
Citations Scopus - 16Web of Science - 7
Co-authors Michael Hensley, Vanessa Murphy
2013 McDonald VM, Higgins I, Gibson PG, 'Insight into Older Peoples' Healthcare Experiences with Managing COPD, Asthma, and Asthma-COPD Overlap', JOURNAL OF ASTHMA, 50 497-504 (2013) [C1]
DOI 10.3109/02770903.2013.790415
Citations Scopus - 3Web of Science - 4
Co-authors Isabel Higgins, Vanessa Mcdonald
2013 Namazy JA, Murphy VE, Powell H, Gibson PG, Chambers C, Schatz M, 'Effects of asthma severity, exacerbations and oral corticosteroids on perinatal outcomes', EUROPEAN RESPIRATORY JOURNAL, 41 1082-1090 (2013) [C1]
DOI 10.1183/09031936.00195111
Citations Scopus - 30Web of Science - 17
Co-authors Vanessa Murphy
2013 Gibson PG, 'Why inflammatory phenotyping is necessary for successful drug evaluation in asthma and COPD', EUROPEAN RESPIRATORY JOURNAL, 42 891-892 (2013) [C3]
DOI 10.1183/09031936.00038713
Citations Scopus - 3Web of Science - 2
2013 Jensen ME, Gibson PG, Collins CE, Wood LG, 'Airway and systemic inflammation in obese children with asthma', EUROPEAN RESPIRATORY JOURNAL, 42 1012-1019 (2013) [C1]
DOI 10.1183/09031936.00124912
Citations Scopus - 24Web of Science - 13
Co-authors Clare Collins, Lisa Wood
2013 Simpson JL, Gibson PG, Yang IA, Upham J, James A, Reynolds PN, Hodge S, 'Impaired macrophage phagocytosis in non-eosinophilic asthma', CLINICAL AND EXPERIMENTAL ALLERGY, 43 29-35 (2013) [C1]
DOI 10.1111/j.1365-2222.2012.04075.x
Citations Scopus - 28Web of Science - 18
Co-authors Jodie Simpson
2013 Jensen ME, Gibson PG, Collins CE, Hilton JM, Wood LG, 'Diet-induced weight loss in obese children with asthma: a randomized controlled trial', CLINICAL AND EXPERIMENTAL ALLERGY, 43 775-784 (2013) [C1]
DOI 10.1111/cea.12115
Citations Scopus - 22Web of Science - 16
Co-authors Clare Collins, Lisa Wood
2013 Simpson JL, McDonald VM, Baines KJ, Oreo KM, Wang F, Hansbro PM, Gibson PG, 'Influence of Age, Past Smoking, and Disease Severity on TLR2, Neutrophilic Inflammation, and MMP-9 Levels in COPD', MEDIATORS OF INFLAMMATION, (2013) [C1]
DOI 10.1155/2013/462934
Citations Scopus - 10Web of Science - 7
Co-authors Jodie Simpson, Philip Hansbro, Katherine Baines, Vanessa Mcdonald
2013 McDonald VM, Higgins I, Gibson PG, 'Managing Older Patients with Coexistent Asthma and Chronic Obstructive Pulmonary Disease Diagnostic and Therapeutic Challenges', DRUGS & AGING, 30 1-17 (2013) [C1]
DOI 10.1007/s40266-012-0042-z
Citations Scopus - 15Web of Science - 7
Co-authors Vanessa Mcdonald, Isabel Higgins
2013 Berthon BS, Macdonald-Wicks LK, Gibson PG, Wood LG, 'Investigation of the association between dietary intake, disease severity and airway inflammation in asthma', RESPIROLOGY, 18 447-454 (2013) [C1]
DOI 10.1111/resp.12015
Citations Scopus - 16Web of Science - 12
Co-authors Lesley Wicks, Lisa Wood
2013 Vanders RL, Gibson PG, Wark PAB, Murphy VE, 'Alterations in inflammatory, antiviral and regulatory cytokine responses in peripheral blood mononuclear cells from pregnant women with asthma', RESPIROLOGY, 18 827-833 (2013) [C1]
DOI 10.1111/resp.12068
Citations Scopus - 8Web of Science - 5
Co-authors Vanessa Murphy, Peter Wark
2013 Brooks CR, Gibson PG, Douwes J, Van Dalen CJ, Simpson JL, 'Relationship between airway neutrophilia and ageing in asthmatics and non-asthmatics', RESPIROLOGY, 18 857-865 (2013) [C1]
DOI 10.1111/resp.12079
Citations Scopus - 10Web of Science - 8
Co-authors Jodie Simpson
2013 Vertigan AE, Bone SL, Gibson PG, 'Laryngeal sensory dysfunction in laryngeal hypersensitivity syndrome', RESPIROLOGY, 18 948-956 (2013) [C1]
DOI 10.1111/resp.12103
Citations Scopus - 12Web of Science - 5
2013 Porsbjerg CM, Gibson PG, Pretto JJ, Salome CM, Brown NJ, Berend N, King GG, 'Relationship between airway pathophysiology and airway inflammation in older asthmatics', RESPIROLOGY, 18 1128-1134 (2013) [C1]
DOI 10.1111/resp.12142
Citations Scopus - 9Web of Science - 8
2013 Scott HA, Gibson PG, Garg ML, Pretto JJ, Morgan PJ, Callister R, Wood LG, 'Dietary restriction and exercise improve airway inflammation and clinical outcomes in overweight and obese asthma: a randomized trial', Clinical and Experimental Allergy, 43 36-49 (2013) [C1]
DOI 10.1111/cea.12004
Citations Scopus - 41Web of Science - 28
Co-authors Lisa Wood, Hayley Scott, Philip Morgan, Robin Callister, Manohar Garg
2013 Baines KJ, Hsu AC-Y, Tooze M, Gunawardhana LP, Gibson PG, Wark PAB, 'Novel immune genes associated with excessive inflammatory and antiviral responses to rhinovirus in COPD', RESPIRATORY RESEARCH, 14 (2013) [C1]
DOI 10.1186/1465-9921-14-15
Citations Scopus - 13Web of Science - 9
Co-authors Katherine Baines, Peter Wark, Alan Hsu
2013 Gao P, Simpson JL, Zhang J, Gibson PG, 'Galectin-3: its role in asthma and potential as an anti-inflammatory target', RESPIRATORY RESEARCH, 14 (2013) [C1]
DOI 10.1186/1465-9921-14-136
Citations Scopus - 9Web of Science - 9
Co-authors Jodie Simpson
2013 Murphy VE, Wang G, Namazy JA, Powell H, Gibson PG, Chambers C, Schatz M, 'The risk of congenital malformations, perinatal mortality and neonatal hospitalisation among pregnant women with asthma: a systematic review and meta-analysis', BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 120 812-822 (2013) [C1]
DOI 10.1111/1471-0528.12224
Citations Scopus - 26Web of Science - 16
Co-authors Vanessa Murphy
2013 Jensen ME, Gibson PG, Collins CE, Hilton JM, Latham-Smith F, Wood LG, 'Increased sleep latency and reduced sleep duration in children with asthma', SLEEP AND BREATHING, 17 281-287 (2013) [C1]
DOI 10.1007/s11325-012-0687-1
Citations Scopus - 7Web of Science - 5
Co-authors Lisa Wood, Clare Collins
2013 Fu J-J, Baines KJ, Wood LG, Gibson PG, 'Systemic Inflammation Is Associated with Differential Gene Expression and Airway Neutrophilia in Asthma', OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY, 17 187-199 (2013) [C1]
DOI 10.1089/omi.2012.0104
Citations Scopus - 18Web of Science - 11
Co-authors Lisa Wood, Katherine Baines
2013 Gao P, Gibson PG, Zhang J, He X, Hao Y, Li P, Liu H, 'The safety of sputum induction in adults with acute exacerbation of COPD', CLINICAL RESPIRATORY JOURNAL, 7 101-109 (2013) [C1]
DOI 10.1111/j.1752-699X.2012.00291.x
Citations Scopus - 5Web of Science - 5
2013 Mcdonald VM, Simpson JL, Mcelduff P, Gibson PG, 'Older peoples' perception of tests used in the assessment and management of COPD and asthma', Clinical Respiratory Journal, 7 367-374 (2013) [C1]

Objectives: Outcome assessment is an important part of the management of airways disease, yet older adults may have difficulty with the burden of testing. This study evaluated the... [more]

Objectives: Outcome assessment is an important part of the management of airways disease, yet older adults may have difficulty with the burden of testing. This study evaluated the patient perception of tests used for the assessment of airways disease in older people. Data Source: Older adults (>55 years) with obstructive airway disease and healthy controls (N=56) underwent inhaler technique assessment, skin allergy testing, venepuncture, fractional exhaled nitric oxide (FENO) and gas diffusion measurement, exercise testing, sputum induction, and questionnaire assessment. They then completed an assessment burden questionnaire across five domains: difficulty, discomfort, pain, symptoms and test duration. Results: Test perception was generally favourable. Induced sputum had the greatest test burden perceived as being more difficult (mean 0.83, P=0.001), associated with more discomfort (mean 1.3, P<0.001), more painful (0.46, P=0.019), longer test duration (0.84, P<0.001) and worsening symptoms (0.55, P=0.001) than the questionnaires. FENO had a more favourable assessment but was assessed to be difficult to perform. Inhaler technique received the most favourable assessment. Conclusions: Older adults hold favourable perceptions to a range of tests that they might encounter in the course of their care for airway disease. The newer tests of sputum induction and FENO have some observed difficulties, in particular sputum induction. The results of this study can inform current practice by including details of the test and its associated adverse effects when conducting the test, as well as providing clear explanations of the utility of tests and how the results might aid in patient care. © 2013 John Wiley & Sons Ltd.

DOI 10.1111/crj.12017
Co-authors Jodie Simpson, Vanessa Mcdonald
2013 Gao P, Zhang J, He X, Hao Y, Wang K, Gibson PG, 'Sputum Inflammatory Cell-Based Classification of Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease', PLOS ONE, 8 (2013) [C1]
DOI 10.1371/journal.pone.0057678
Citations Scopus - 14Web of Science - 7
2012 Wood LG, Garg ML, Smart JM, Scott HA, Barker D, Gibson PG, 'Manipulating antioxidant intake in asthma: A randomized controlled trial', American Journal of Clinical Nutrition, 96 534-543 (2012) [C1]
Citations Scopus - 41Web of Science - 30
Co-authors Hayley Scott, Lisa Wood, Manohar Garg
2012 Wood LG, Baines KJ, Fu J, Scott HA, Gibson PG, 'The neutrophilic inflammatory phenotype is associated with systemic inflammation in asthma', Chest, 142 86-93 (2012) [C1]
Citations Scopus - 78Web of Science - 50
Co-authors Hayley Scott, Lisa Wood, Katherine Baines
2012 Thorburn AN, Foster PS, Gibson PG, Hansbro PM, 'Components of streptococcus pneumoniae suppress allergic airways disease and NKT cells by inducing regulatory T cells', The Journal of Immunology, 188 4611-4620 (2012) [C1]
Citations Scopus - 29Web of Science - 20
Co-authors Paul Foster, Philip Hansbro
2012 Vanders RL, Wark PA, Murphy VE, Gibson PG, 'Pregnant women have attenuated innate interferon responses to 2009 pandemic influenza a virus subtype H1N1', Journal of Infectious Diseases, 206 646-653 (2012) [C1]
Citations Scopus - 17Web of Science - 14
Co-authors Vanessa Murphy, Peter Wark
2012 Chang AB, Yerkovich ST, Gibson PG, Anderson-James S, Petsky HL, Carroll ML, et al., 'Pulmonary innate immunity in children with protracted bacterial bronchitis', Journal of Pediatrics, 161 621-625 (2012) [C1]
Citations Scopus - 19Web of Science - 12
2012 Murphy VE, Namazy JA, Powell H, Schatz M, Chambers C, Attia J, Gibson PG, 'A Meta-Analysis of Adverse Perinatal Outcomes in Women With Asthma EDITORIAL COMMENT', OBSTETRICAL & GYNECOLOGICAL SURVEY, 67 77-78 (2012) [C3]
DOI 10.1097/OGX.0b013e318247c54d
Co-authors John Attia
2012 Pavord ID, Gibson PG, 'Inflammometry: The current state of play', Thorax, 67 191-192 (2012) [C3]
Citations Scopus - 21Web of Science - 17
2012 Pavord ID, Gibson PG, 'Use of sputum eosinophil counts to guide management in children with severe asthma [response]', Thorax, 67 1016 (2012) [C3]
Citations Scopus - 1Web of Science - 1
2012 Essilfie A-T, Simpson JL, Dunkley ML, Morgan LC, Oliver BG, Gibson PG, et al., 'Combined haemophilus influenzae respiratory infection and allergic airways disease drives chronic infection and features of neutrophilic asthma', Thorax, 67 588-599 (2012) [C1]
Citations Scopus - 43Web of Science - 32
Co-authors Jodie Simpson, Margaret Dunkley, Philip Hansbro, Paul Foster
2012 Vanders RL, Gibson PG, Murphy VE, Wark PAB, 'Impaired type I and III interferon response to rhinovirus infection during pregnancy and asthma', Thorax, 67 209-214 (2012) [C1]
Citations Scopus - 31Web of Science - 22
Co-authors Vanessa Murphy, Peter Wark
2012 Powell H, Gibson PG, 'Exhaled nitric oxide as a guide to management of asthma in pregnancy Reply', LANCET, 379 708-709 (2012) [C3]
2012 Powell H, Gibson PG, 'Reply: Exhaled nitric oxide as a guide to management of asthma in pregnancy', Lancet, 379 708-709 (2012) [C3]
2012 Powell H, Gibson PG, 'Management of asthma in pregnancy - Authors' reply', The Lancet, 379 e43 (2012) [C3]
2012 Ryan NM, Birring SS, Gibson PG, 'Gabapentin for refractory chronic cough: a randomised, double-blind, placebo-controlled trial', The Lancet, 380 1583-1589 (2012) [C1]
Citations Scopus - 80Web of Science - 54
Co-authors Nicole Ryan
2012 Vertigan AE, Gibson PG, 'The role of speech pathology in the management of patients with chronic refractory cough', Lung, 190 35-40 (2012) [C1]
Citations Scopus - 13Web of Science - 10
2012 Sukkar MB, Wood LG, Tooze MK, Simpson JL, McDonald VM, Gibson PG, Wark PA, 'Soluble RAGE is deficient in neutrophilic asthma and COPD', European Respiratory Journal, 39 721-729 (2012) [C1]
Co-authors Jodie Simpson, Lisa Wood, Peter Wark, Vanessa Mcdonald
2012 Wark PA, Tooze M, Cheese L, Whitehead BF, Gibson PG, Wark K, McDonald VM, 'Viral infections trigger exacerbations of cystic fibrosis in adults and children', European Respiratory Journal, 40 510-512 (2012) [C1]
DOI 10.1183/09031936.00202311
Citations Scopus - 10Web of Science - 9
Co-authors Peter Wark, Vanessa Mcdonald
2012 Ryan NM, Vertigan AE, Ferguson JK, Wark PA, Gibson PG, 'Clinical and physiological features of postinfectious chronic cough associated with H1N1 infection', Respiratory Medicine, 106 138-144 (2012) [C1]
DOI 10.1016/j.rmed.2011.10.007
Citations Scopus - 7Web of Science - 5
Co-authors Peter Wark, John Ferguson, Nicole Ryan
2012 McDonald VM, Gibson PG, 'Exacerbations of severe asthma', Clinical and Experimental Allergy, 42 670-677 (2012) [C1]
Citations Scopus - 18Web of Science - 15
Co-authors Vanessa Mcdonald
2012 Wood LG, Gibson PG, 'Adiponectin: The link between obesity and asthma in women?', American Journal of Respiratory and Critical Care Medicine, 186 1-2 (2012) [C3]
Citations Scopus - 5Web of Science - 3
Co-authors Lisa Wood
2012 Scott HA, Gibson PG, Garg ML, Pretto JJ, Morgan PJ, Callister R, Wood LG, 'Relationship between body composition, inflammation and lung function in overweight and obese asthma', Respiratory Research, 13 1-10 (2012) [C1]
Citations Scopus - 15Web of Science - 10
Co-authors Lisa Wood, Hayley Scott, Manohar Garg, Robin Callister, Philip Morgan
2012 Murphy VE, Namazy JA, Powell H, Schatz M, Chambers C, Attia JR, Gibson PG, 'Severity of asthma in pregnancy affects perinatal outcomes - Authors' Reply', BJOG - An International Journal of Obstetrics and Gynaecology, 119 508-509 (2012) [C3]
DOI 10.1111/j.1471-0528.2011.03258.x
Citations Scopus - 1
Co-authors Vanessa Murphy, John Attia
2012 Jensen ME, Wood LG, Gibson PG, 'Obesity and childhood asthma - Mechanisms and manifestations', Current Opinion in Allergy and Clinical Immunology, 12 186-192 (2012) [C1]
Citations Scopus - 30Web of Science - 26
Co-authors Lisa Wood
2011 Gibson PG, 'Simple clinical score', Clinical Medicine, 11 96 (2011) [C3]
2011 McDonald VM, Higgins I, Simpson JL, Gibson PG, 'The importance of clinical management problems in older people with COPD and asthma: Do patients and physicians agree?', Primary Care Respiratory Journal, 20 389-395 (2011) [C1]

Background: COPD and asthma in older people are complex conditions associated with multiple clinical problems. The relative importance of these problems to both patients and physi... [more]

Background: COPD and asthma in older people are complex conditions associated with multiple clinical problems. The relative importance of these problems to both patients and physicians and the level of agreement between them is largely unknown. Methods: Older people with asthma and COPD underwent a multidimensional assessment to characterise the prevalence of clinical problems. Each individual's problems were then summarised and presented separately to the patient and physician to rate problem importance. Problems were scored using a 5-point Likert scale from unimportant to very important. Results: The highest-rated problems were dyspnoea, activity limitation and airway inflammation, and these areas had good patientphysician concordance. Poor concordance was found for inhaler technique adequacy, airflow obstruction and obesity. Good concordance was found for written action plans, but this was less important to both patients and physicians. Conclusions: In asthma and COPD, patients and their physicians agree about the importance of managing activity limitation, dyspnoea, and airway inflammation. Other areas of management had little concordance or were viewed as less important. Self-management skills were not rated as important by patients and this may hinder successful management. Eliciting problems and addressing their importance to treatment goals may improve care in COPD and asthma. © 2011 Primary Care Respiratory Society UK. All rights reserved.

Citations Scopus - 19Web of Science - 15
Co-authors Isabel Higgins, Jodie Simpson, Vanessa Mcdonald
2011 Gibson PG, 'Asthma phenotypes in childhood', Paediatric Respiratory Reviews, 12 151 (2011) [C3]
DOI 10.1016/j.prrv.2011.02.006
Citations Scopus - 1Web of Science - 1
2011 Jensen ME, Collins CE, Gibson PG, Wood LG, 'The obesity phenotype in children with asthma', Paediatric Respiratory Reviews, 12 152-159 (2011) [C1]
DOI 10.1016/j.prrv.2011.01.009
Citations Scopus - 19Web of Science - 21
Co-authors Clare Collins, Lisa Wood
2011 Essilfie A-T, Simpson JL, Horvat JC, Preston JA, Dunkley ML, Foster PS, et al., 'Haemophilus influenzae infection drives IL-17-mediated neutrophilic allergic airways disease', PLoS Pathogens, 7 e1002244 (2011) [C1]
Co-authors Jodie Simpson, Philip Hansbro, Paul Foster, Margaret Dunkley, Jay Horvat
2011 Baines KJ, Simpson JL, Gibson PG, 'Innate immune responses are increased in chronic obstructive pulmonary disease', PLoS ONE, 36 e18426 (2011) [C1]
DOI 10.1371/journal.pone.0018426
Citations Scopus - 35Web of Science - 20
Co-authors Jodie Simpson, Katherine Baines
2011 McDonald VM, Simpson JL, Higgins IJ, Gibson PG, 'Multidimensional assessment of older people with asthma and COPD: Clinical management and health status', Age and Ageing, 40 42-49 (2011) [C1]
DOI 10.1093/ageing/afq134
Citations Scopus - 30Web of Science - 18
Co-authors Isabel Higgins, Vanessa Mcdonald, Jodie Simpson
2011 Chang AB, Gibson PG, Willis C, Petsky HL, Widdicombe JG, Masters IB, Robertson CF, 'Do sex and atopy influence cough outcome measurements in children?', Chest, 140 324-330 (2011) [C1]
DOI 10.1378/chest.10-2507
Citations Scopus - 6Web of Science - 4
2011 Baines KJ, Simpson JL, Wood LG, Scott R, Gibson PG, 'Systemic upregulation of neutrophil a-defensins and serine proteases in neutrophilic asthma', Thorax, 66 942-947 (2011) [C1]
Citations Scopus - 28Web of Science - 18
Co-authors Lisa Wood, Rodney Scott, Katherine Baines, Jodie Simpson
2011 Wood LG, Garg ML, Gibson PG, 'A high-fat challenge increases airway inflammation and impairs bronchodilator recovery in asthma', Journal of Allergy and Clinical Immunology, 127 1133-1140 (2011) [C1]
DOI 10.1016/j.jaci.2011.01.036
Citations Scopus - 56Web of Science - 42
Co-authors Lisa Wood, Manohar Garg
2011 Baines KJ, Simpson JL, Wood LG, Scott R, Gibson PG, 'Transcriptional phenotypes of asthma defined by gene expression profiling of induced sputum samples', Journal of Allergy and Clinical Immunology, 127 153.e9-160.e9 (2011) [C1]
DOI 10.1016/j.jaci.2010.10.024
Citations Scopus - 82Web of Science - 62
Co-authors Lisa Wood, Jodie Simpson, Katherine Baines, Rodney Scott
2011 Powell GH, Murphy VE, Taylor DR, Hensley MJ, McCaffery K, Giles W, et al., 'Management of asthma in pregnancy guided by measurement of fraction of exhaled nitric oxide: A double-blind, randomised controlled trial', The Lancet, 378 983-990 (2011) [C1]
DOI 10.1016/s0140-6736(11)60971-9
Citations Scopus - 125Web of Science - 86
Co-authors Vanessa Murphy, Michael Hensley
2011 Murphy VE, Gibson PG, 'Asthma in pregnancy', Clinics in Chest Medicine, 32 93-110 (2011) [C1]
Citations Scopus - 30Web of Science - 12
Co-authors Vanessa Murphy
2011 Powell H, McCaffery K, Murphy VE, Hensley MJ, Clifton VL, Giles WB, Gibson PG, 'Psychosocial outcomes are related to asthma control and quality of life in pregnant women with asthma', Journal of Asthma, 48 1032-1040 (2011) [C1]
DOI 10.3109/02770903.2011.631239
Citations Scopus - 24Web of Science - 16
Co-authors Michael Hensley, Vanessa Murphy
2011 Vertigan AE, Gibson PG, 'Chronic refractory cough as a sensory neuropathy: Evidence from a reinterpretation of cough triggers', Journal of Voice, 25 596-601 (2011) [C1]
DOI 10.1016/j.jvoice.2010.07.009
Citations Scopus - 38Web of Science - 27
2011 Wang F, He XY, Baines KJ, Gunawardhana LP, Simpson JL, Li F, Gibson PG, 'Different inflammatory phenotypes in adults and children with acute asthma', European Respiratory Journal, 38 567-574 (2011) [C1]
DOI 10.1183/09031936.00170110
Citations Scopus - 35Web of Science - 27
Co-authors Katherine Baines, Jodie Simpson
2011 Preston JA, Thorburn AN, Starkey MR, Beckett EL, Horvat JC, Wade MA, et al., 'Streptococcus pneumoniae infection suppresses allergic airways disease by inducing regulatory T-cells', European Respiratory Journal, 37 53-64 (2011) [C1]
DOI 10.1183/09031936.00049510
Citations Scopus - 36Web of Science - 29
Co-authors Paul Foster, Malcolm Starkey, Philip Hansbro, Jay Horvat
2011 Wang F, Gibson PG, 'Respiratory Chlamydophyla pneumoniae resides primarily in the lower airway', European Respiratory Journal, 38 995 (2011) [C3]
DOI 10.1183/09031936.00076011
2011 Scott HA, Gibson PG, Garg ML, Wood LG, 'Airway inflammation is augmented by obesity and fatty acids in asthma', European Respiratory Journal, 38 594-602 (2011) [C1]
Citations Scopus - 77Web of Science - 66
Co-authors Lisa Wood, Hayley Scott, Manohar Garg
2011 Wood LG, Simpson JL, Wark PA, Powell H, Gibson PG, 'Characterization of innate immune signalling receptors in virus-induced acute asthma', Clinical and Experimental Allergy, 41 640-648 (2011) [C1]
DOI 10.1111/j.1365-2222.2010.03669.x
Citations Scopus - 17Web of Science - 13
Co-authors Peter Wark, Jodie Simpson, Lisa Wood
2011 Verrills NM, Irwin JA, He XY, Wood LG, Powell H, Simpson JL, et al., 'Identification of novel diagnostic biomarkers for asthma and chronic obstructive pulmonary disease', American Journal of Respiratory and Critical Care Medicine, 183 1633-1643 (2011) [C1]
DOI 10.1164/rccm.201010-1623OC
Citations Scopus - 43Web of Science - 34
Co-authors Jodie Simpson, Vanessa Mcdonald, Alistair Sim, Lisa Wood, Nikki Verrills
2011 Hodyl NA, Stark MJ, Osei-Kumah A, Bowman M, Gibson PG, Clifton VL, 'Fetal glucocorticoid-regulated pathways are not affected by inhaled corticosteroid use for asthma during pregnancy', American Journal of Respiratory and Critical Care Medicine, 183 716-722 (2011) [C1]
DOI 10.1164/rccm.201007-1188oc
Citations Scopus - 21Web of Science - 15
Co-authors Maria Bowman, Vicki Clifton
2011 Wood LG, Powell H, Grissell TV, Davies BL, Shafren DR, Whitehead BF, et al., 'Persistence of rhinovirus RNA and IP-10 gene expression after acute asthma', Respirology, 16 291-299 (2011) [C1]
DOI 10.1111/j.1440-1843.2010.01897.x
Citations Scopus - 9Web of Science - 9
Co-authors Lisa Wood, Michael Hensley
2011 McDonald VM, Vertigan AE, Gibson PG, 'How to set up a severe asthma service', Respirology, 16 900-911 (2011) [C1]
DOI 10.1111/j.1440-1843.2011.02012.x
Citations Scopus - 11Web of Science - 5
Co-authors Vanessa Mcdonald
2011 Thomas R, Ferguson JK, Coombs G, Gibson PG, 'Community-acquired methicillin-resistant Staphylococcus aureus pneumonia: A clinical audit', Respirology, 16 926-931 (2011) [C1]
Citations Scopus - 11Web of Science - 10
Co-authors John Ferguson
2011 Vertigan AE, Gibson PG, 'Urge to cough and its application to the behavioural treatment of cough', Bratislavske Lekarske Listy, 112 102-108 (2011) [C1]
Citations Scopus - 4Web of Science - 4
2011 Gibson PG, Ryan NM, 'Cough pharmacotherapy: Current and future status', Expert Opinion on Pharmacotherapy, 12 1745-1755 (2011) [C1]
Citations Scopus - 14Web of Science - 11
Co-authors Nicole Ryan
2011 Murphy VE, Namazy JA, Powell H, Schatz M, Chambers C, Attia JR, Gibson PG, 'A meta-analysis of adverse perinatal outcomes in women with asthma', BJOG: An International Journal of Obstetrics and Gynaecology, 118 1314-1323 (2011) [C1]
DOI 10.1111/j.1471-0528.2011.03055.x
Citations Scopus - 94Web of Science - 58
Co-authors Vanessa Murphy, John Attia
2010 Ryan NM, Vertigan AE, Bone S, Gibson PG, 'Cough reflex sensitivity improves with speech language pathology management of refractory chronic cough', Cough, 6 1-8 (2010) [C1]
Citations Scopus - 26
Co-authors Nicole Ryan
2010 Wood LG, Gibson PG, 'Reduced circulating antioxidant defences are associated with airway hyper-responsiveness, poor control and severe disease pattern in asthma', British Journal of Nutrition, 103 735-741 (2010) [C1]
DOI 10.1017/s0007114509992376
Citations Scopus - 15Web of Science - 16
Co-authors Lisa Wood
2010 Barnes PJ, Dweik RA, Gelb AF, Gibson PG, George SC, Grasemann H, et al., 'Exhaled nitric oxide in pulmonary diseases: A comprehensive review', Chest, 138 682-692 (2010) [C1]
DOI 10.1378/chest.09-2090
Citations Scopus - 195Web of Science - 146
2010 Horvat JC, Starkey MR, Kim RY, Beagley KW, Preston JA, Gibson PG, et al., 'Chlamydial respiratory infection during allergen sensitization drives neutrophilic allergic airways disease', Journal of Immunology, 184 4159-4169 (2010) [C1]
DOI 10.4049/jimmunol.0902287
Citations Scopus - 44Web of Science - 36
Co-authors Jay Horvat, Malcolm Starkey, Philip Hansbro, Paul Foster
2010 Li J, Wang W, Baines KJ, Bowden NA, Hansbro PM, Gibson PG, et al., 'IL-27/IFN-y induce MyD88-dependent steroid-resistant airway hyperresponsiveness by inhibiting glucocorticoid signaling in macrophages', Journal of Immunology, 185 4401-4409 (2010) [C1]
DOI 10.4049/jimmunol.1001039
Citations Scopus - 46Web of Science - 34
Co-authors Paul Foster, Philip Hansbro, Nikola Bowden, Katherine Baines, Ming Yang
2010 Gibson PG, Chang AB, Glasgow NJ, Holmes PW, Katelaris P, Kemp AS, et al., 'CICADA: Cough in children and adults: Diagnosis and assessment. Australian Cough Guidelines summary statement', Medical Journal of Australia, 192 265-271 (2010) [C2]
Citations Scopus - 44Web of Science - 35
2010 Gibson PG, Chang AB, Kemp AS, 'CICADA: Cough in Children and Adults: Diagnosis and Assessment. Australian Cough Guidelines summary statement REPLY', Medical Journal of Australia, 192 672 (2010) [C3]
Citations Scopus - 1
2010 Thorburn AN, O'Sullivan BJ, Thomas R, Kumar RK, Foster PS, Gibson PG, Hansbro PM, 'Pneumococcal conjugate vaccine-induced regulatory T cells suppress the development of allergic airways disease', Thorax, 65 1053-1060 (2010) [C1]
DOI 10.1136/thx.2009.131508
Citations Scopus - 32Web of Science - 29
Co-authors Paul Foster, Philip Hansbro
2010 Murphy VE, Clifton VL, Gibson PG, 'The effect of cigarette smoking on asthma control during exacerbations in pregnant women', Thorax, 65 739-744 (2010) [C1]
DOI 10.1136/thx.2009.124941
Citations Scopus - 27Web of Science - 17
Co-authors Vicki Clifton, Vanessa Murphy
2010 Hodyl NA, Wyper HJ, Osei-Kumah A, Scott NM, Murphy VE, Gibson PG, et al., 'Sex-specific associations between cortisol and birth weight in pregnancies complicated by asthma are not due to differential glucocorticoid receptor expression', Thorax, 65 677-683 (2010) [C1]
DOI 10.1136/thx.2009.123091
Citations Scopus - 17Web of Science - 13
Co-authors Vicki Clifton, Roger Smith, Vanessa Murphy
2010 Horvat JC, Starkey MR, Kim RY, Phipps S, Gibson PG, Beagley KW, et al., 'Early-life chlamydial lung infection enhances allergic airways disease through age-dependent differences in immunopathology', Journal of Allergy and Clinical Immunology, 125 617-625 (2010) [C1]
DOI 10.1016/j.jaci.2009.10.018
Co-authors Malcolm Starkey, Philip Hansbro, Paul Foster, Jay Horvat
2010 Gibson PG, McDonald VM, Marks GB, 'Asthma in older adults', The Lancet, 376 803-813 (2010) [C1]
DOI 10.1016/S0140-6736(10)61087-2
Citations Scopus - 153Web of Science - 99
Co-authors Vanessa Mcdonald
2010 Baines KJ, Simpson JL, Bowden NA, Scott R, Gibson PG, 'Differential gene expression and cytokine production from neutrophils in asthma phenotypes', European Respiratory Journal, 35 522-531 (2010) [C1]
DOI 10.1183/09031936.00027409
Citations Scopus - 39Web of Science - 26
Co-authors Jodie Simpson, Nikola Bowden, Rodney Scott, Katherine Baines
2010 Wood LG, Attia JR, McElduff P, McEvoy MA, Gibson PG, 'Assessment of dietary fat intake and innate immune activation as risk factors for impaired lung function', European Journal of Clinical Nutrition, 64 818-825 (2010) [C1]
DOI 10.1038/ejcn.2010.68
Citations Scopus - 6Web of Science - 5
Co-authors Mark Mcevoy, Lisa Wood, John Attia
2010 Reddel HK, Gibson PG, Peters MJ, Wark PA, Sand IB, Hoyos CM, Jenkins CR, 'Down-titration from high-dose combination therapy in asthma: Removal of long-acting b2-agonist', Respiratory Medicine, 104 1110-1120 (2010) [C1]
DOI 10.1016/j.rmed.2010.04.003
Citations Scopus - 36Web of Science - 29
Co-authors Peter Wark
2010 Wood LG, Simpson JL, Hansbro PM, Gibson PG, 'Potentially pathogenic bacteria cultured from the sputum of stable asthmatics are associated with increased 8-isoprostane and airway neutrophilia', Free Radical Research, 44 146-154 (2010) [C1]
DOI 10.3109/10715760903362576
Citations Scopus - 32Web of Science - 19
Co-authors Jodie Simpson, Philip Hansbro, Lisa Wood
2010 Wood LG, Powell HG, Gibson PG, 'Mannitol challenge for assessment of airway responsiveness, airway inflammation and inflammatory phenotype in asthma', Clinical & Experimental Allergy, 40 232-241 (2010) [C1]
DOI 10.1111/j.1365-2222.2009.03371.x
Citations Scopus - 21Web of Science - 18
Co-authors Lisa Wood
2009 Walters JAE, Gibson PG, Wood-Baker R, Hannay M, Walters EH, 'Systemic corticosteroids for acute exacerbations of chronic obstructive pulmonary disease', Cochrane Database of Systematic Reviews, - CD001288 (2009) [C1]
DOI 10.1002/14651858.cd001288.pub3
Citations Scopus - 83Web of Science - 38
2009 Thorburn AN, Hansbro PM, Gibson PG, 'Pneumococcal vaccines for allergic airways diseases', Expert Opinion on Biological Therapy, 9 621-629 (2009) [C1]
DOI 10.1517/14712590902916999
Citations Scopus - 15Web of Science - 12
Co-authors Philip Hansbro
2009 Baines KJ, Wood LG, Gibson PG, 'The nutrigenomics of asthma: Molecular mechanisms of airway neutrophilia following dietary antioxidant withdrawal', OMICS: A Journal of Integrative Biology, 13 355-365 (2009) [C1]
DOI 10.1089/omi.2009.0042
Citations Scopus - 15Web of Science - 11
Co-authors Lisa Wood, Katherine Baines
2009 Ryan NM, Vertigan AE, Gibson PG, 'Chronic cough and laryngeal dysfunction improve with specific treatment of cough and paradoxical vocal fold movement', Cough, 5 1-8 (2009) [C1]
DOI 10.1186/1745-9974-5-4
Citations Scopus - 17
Co-authors Nicole Ryan
2009 Gibson PG, Simpson JL, 'The overlap syndrome of asthma and COPD: What are its features and how important is it?', Thorax, 64 728-735 (2009) [C1]
DOI 10.1136/thx.2008.108027
Citations Scopus - 249Web of Science - 174
Co-authors Jodie Simpson
2009 Boyd M, Lasserson TJ, McKean MC, Gibson PG, Ducharme FM, Haby M, 'Interventions for educating children who are at risk of asthma-related emergency department attendance', Cochrane Database of Systematic Reviews, - CD001290 (2009) [C1]
DOI 10.1002/14651858.cd001290.pub2
Citations Scopus - 54Web of Science - 26
2009 Gibson PG, 'Inflammatory phenotypes in adult asthma: clinical applications', CLINICAL RESPIRATORY JOURNAL, 3 198-206 (2009) [C3]
DOI 10.1111/j.1752-699X.2009.00162.x
Citations Scopus - 46Web of Science - 36
2009 Krishnan JA, Davis SQ, Naureckas ET, Gibson PG, Rowe BH, 'An umbrella review: Corticosteroid therapy for adults with acute asthma', American Journal of Medicine, 122 977-991 (2009) [C1]
DOI 10.1016/j.amjmed.2009.02.013
Citations Scopus - 24Web of Science - 19
2009 Clifton VL, Engel PJ, Smith R, Gibson PG, Brinsmead MW, Giles WB, 'Maternal and neonatal outcomes of pregnancies complicated by asthma in an Australian population', Australian and New Zealand Journal of Obstetrics and Gynaecology, 49 619-626 (2009) [C1]
DOI 10.1111/j.1479-828x.2009.01077.x
Citations Scopus - 33Web of Science - 27
Co-authors Roger Smith
2009 Saedi Some Olia A, Wood LG, Garg ML, Gibson PG, Wark PA, 'Anti-inflammatory effects of long-chain n-3 PUFA in rhinovirus-infected cultured airway epithelial cells', British Journal of Nutrition, 101 533-540 (2009) [C1]
DOI 10.1017/s0007114508025798
Citations Scopus - 16Web of Science - 12
Co-authors Lisa Wood, Peter Wark, Manohar Garg
2009 Ryan NM, Gibson PG, 'Characterization of laryngeal dysfunction in chronic persistent cough', Laryngoscope, 119 640-645 (2009) [C1]
DOI 10.1002/lary.20114
Citations Scopus - 15Web of Science - 12
Co-authors Nicole Ryan
2009 Marks GB, Poulos LM, Jenkins CR, Gibson PG, 'Asthma in older adults: A holistic, person-centred and problem-oriented approach', Medical Journal of Australia, 191 197-199 (2009) [C3]
Citations Scopus - 7Web of Science - 5
2009 Simpson JL, McElduff P, Gibson PG, 'Assessment and reproducibility of non-eosinophilic asthma using induced sputum', Respiration, 79 147-151 (2009) [C1]
DOI 10.1159/000245899
Citations Scopus - 37Web of Science - 30
Co-authors Jodie Simpson
2009 Gibson PG, 'Tackling asthma phenotypes in community studies', Thorax, 64 369-370 (2009) [C3]
DOI 10.1136/thx.2008.109710
Citations Scopus - 5Web of Science - 5
2009 Wood LG, Gibson PG, 'Dietary factors lead to innate immune activation in asthma', Pharmacology and Therapeutics, 123 37-53 (2009) [C1]
DOI 10.1016/j.pharmthera.2009.03.015
Citations Scopus - 34Web of Science - 31
Co-authors Lisa Wood
2009 Simpson JL, Phipps S, Gibson PG, 'Inflammatory mechanisms and treatment of obstructive airway diseases with neutrophilic bronchitis', Pharmacology and Therapeutics, 124 86-95 (2009) [C1]
DOI 10.1016/j.pharmthera.2009.06.004
Citations Scopus - 45Web of Science - 39
Co-authors Jodie Simpson
2009 Wood LG, Scott HA, Garg ML, Gibson PG, 'Innate immune mechanisms linking non-esterified fatty acids and respiratory disease', Progress in Lipid Research, 48 27-43 (2009) [C1]
DOI 10.1016/j.plipres.2008.10.001
Citations Scopus - 28Web of Science - 19
Co-authors Lisa Wood, Hayley Scott, Manohar Garg
2009 Baines KJ, Simpson JL, Scott R, Gibson PG, 'Immune responses of airway neutrophils are impaired in asthma', Experimental Lung Research, 35 554-569 (2009) [C1]
DOI 10.1080/01902140902777490
Citations Scopus - 18Web of Science - 15
Co-authors Rodney Scott, Jodie Simpson, Katherine Baines
2009 Simpson JL, Baines KJ, Boyle MJ, Scott R, Gibson PG, 'Oncostatin M (OSM) is increased in asthma with incompletely reversible airflow obstruction', Experimental Lung Research, 35 781-794 (2009) [C1]
DOI 10.3109/01902140902906412
Citations Scopus - 15Web of Science - 14
Co-authors Jodie Simpson, Katherine Baines, Rodney Scott
2009 Simpson JL, Milne DG, Gibson PG, 'Neutrophilic asthma has different radiographic features to COPD and smokers', Respiratory Medicine, 103 881-887 (2009) [C1]
DOI 10.1016/j.rmed.2008.12.013
Citations Scopus - 15Web of Science - 12
Co-authors Jodie Simpson
2009 Gibson PG, 'Using fractional exhaled nitric oxide to guide asthma therapy: Design and methodological issues for ASthma TReatment ALgorithm studies', Clinical and Experimental Allergy, 39 478-490 (2009) [C1]
DOI 10.1111/j.1365-2222.2009.03226.x
Citations Scopus - 71Web of Science - 61
2009 Saedi Some Olia A, Wood LG, Garg ML, Gibson PG, Wark PA, 'Lycopene enrichment of cultured airway epithelial cells decreases the inflammation induced by rhinovirus infection and lipopolysaccharide', Journal of Nutritional Biochemistry, 20 577-585 (2009) [C1]
DOI 10.1016/j.jnutbio.2008.06.001
Citations Scopus - 30Web of Science - 26
Co-authors Lisa Wood, Peter Wark, Manohar Garg
2009 Reddel HK, Taylor DR, Bateman ED, Boulet L-P, Boushey HA, Busse WW, et al., 'An official American Thoracic Society/European Respiratory Society Statement: Asthma control and exacerbations standardising endpoints for clinical asthma trials and clinical practice', American Journal of Respiratory and Critical Care Medicine, 180 59-99 (2009) [C1]
DOI 10.1164/rccm.200801-060st
Citations Scopus - 671Web of Science - 526
2009 Vandemheen KL, O'Connor A, Bell SC, Freitag A, Bye P, Jeanneret A, et al., 'Randomized trial of a decision aid for patients with cystic fibrosis considering lung transplantation', American Journal of Respiratory and Critical Care Medicine, 180 761-768 (2009) [C1]
DOI 10.1164/rccm.200903-0421oc
Citations Scopus - 25Web of Science - 20
2009 Gibson PG, Vertigan AE, 'Speech pathology for chronic cough: A new approach', Pulmonary Pharmacology & Therapeutics, 22 159-162 (2009) [C1]
DOI 10.1016/j.pupt.2008.11.005
Citations Scopus - 23Web of Science - 14
2009 Widdicombe J, Fontana G, Gibson PG, 'Workshop - Cough: Exercise, speech and music', Pulmonary Pharmacology & Therapeutics, 22 143-147 (2009) [C3]
DOI 10.1016/j.pupt.2008.12.009
Citations Scopus - 6Web of Science - 4
2009 Wark PA, Grissell TV, Davies BL, See HV, Gibson PG, 'Diversity in the bronchial epithelial cell response to infection with different rhinovirus strains', Respirology, 14 180-186 (2009) [C1]
DOI 10.1111/j.1440-1843.2009.01480.x
Citations Scopus - 47Web of Science - 41
Co-authors Peter Wark
2008 Saedi Some Olia A, Wood LG, Garg ML, Gibson PG, Wark PA, 'Supplementation of long chain N-3 polyunsaturated fatty acids increases the utilization of lycopene in cultured airway epithelial cells', Journal of Food Lipids, 15 421-432 (2008) [C1]
DOI 10.1111/j.1745-4522.2008.00130.x
Citations Scopus - 7Web of Science - 4
Co-authors Manohar Garg, Peter Wark, Lisa Wood
2008 Wood LG, Garg ML, Powell H, Gibson PG, 'Lycopene-rich treatments modify noneosinophilic airway inflammation in asthma: Proof of concept', Free Radical Research, 42 94-102 (2008) [C1]
DOI 10.1080/10715760701767307
Citations Scopus - 44Web of Science - 39
Co-authors Lisa Wood, Manohar Garg
2008 Simpson JL, Powell H, Boyle MJ, Scott R, Gibson PG, 'Clarithromycin targets neutrophilic airway inflammation in refractory asthma', American Journal of Respiratory and Critical Care Medicine, 177 148-155 (2008) [C1]
DOI 10.1164/rccm.200707-1134oc
Citations Scopus - 257Web of Science - 187
Co-authors Rodney Scott, Jodie Simpson
2008 Wlodarczyk JH, Gibson PG, Caeser M, 'Impact of inhaled corticosteroids on cortisol suppression in adults with asthma: A quantitative review', Annals of Allergy, Asthma and Immunology, 100 23-30 (2008) [C1]
DOI 10.1016/S1081-1206(10)60400-0
Citations Scopus - 15Web of Science - 11
2008 Murphy VE, Gibson PG, 'Premenstrual asthma: Prevalence, cycle-to-cycle variability and relationship to oral contraceptive use and menstrual symptoms', Journal of Asthma, 45 696-704 (2008) [C1]
DOI 10.1080/02770900802207279
Citations Scopus - 17Web of Science - 12
Co-authors Vanessa Murphy
2008 McDonald VM, Gibson PG, 'Asthma mortality and management in older Australians: Time for a new approach?', Australasian Journal on Ageing, 27 215 (2008) [C3]
DOI 10.1111/j.1741-6612.2008.00322.x
Citations Scopus - 5Web of Science - 4
Co-authors Vanessa Mcdonald
2008 Manning P, Gibson PG, Lasserson TJ, 'Ciclesonide versus other inhaled steroids for chronic asthma in children and adults', Cochrane Database of Systematic Reviews, CD007031 (2008) [C1]
DOI 10.1002/14651858.cd007031
Citations Scopus - 19Web of Science - 10
2008 Manning P, Gibson PG, Lasserson TJ, 'Ciclesonide versus placebo for chronic asthma in adults and children', Cochrane Database of Systematic Reviews, CD006217 (2008) [C1]
DOI 10.1002/14651858.cd006217.pub2
Citations Scopus - 6Web of Science - 7
2008 Ryan NM, Gibson PG, 'Extrathoracic airway hyperresponsiveness as a mechanism of post infectious cough: Case report', Cough, 4 1-4 (2008) [C3]
DOI 10.1186/1745-9974-4-7
Citations Scopus - 8
Co-authors Nicole Ryan
2008 Vertigan AE, Gibson PG, Theodoros DG, Winkworth AL, 'The role of sensory dysfunction in the development of voice disorders, chronic cough and paradoxical vocal fold movement', International Journal of Speech-Language Pathology, 10 231-244 (2008) [C1]
DOI 10.1080/17549500801932089
Citations Scopus - 8Web of Science - 4
2008 Powell H, Smart JM, Wood LG, Grissell TV, Shafren DR, Hensley MJ, Gibson PG, 'Validity of the common cold questionnaire (CCQ) in asthma exacerbations', PLoS ONE, 3 e1802 (2008) [C1]
DOI 10.1371/journal.pone.0001802
Co-authors Michael Hensley, Lisa Wood
2008 Marchant JM, Gibson PG, Grissell TV, Timmins NL, Masters IB, Chang AB, 'Prospective assessment of protracted bacterial bronchitis: Airway inflammation and innate immune activation', Pediatric Pulmonology, 43 1092-1099 (2008) [C1]
DOI 10.1002/ppul.20906
Citations Scopus - 42Web of Science - 30
2008 Taylor DR, Bateman ED, Boulet LP, Boushey HA, Busse WW, Casale TB, et al., 'A new perspective on concepts of asthma severity and control', European Respiratory Journal, 32 545-554 (2008) [C1]
DOI 10.1183/09031936.00155307
Citations Scopus - 225Web of Science - 180
2008 Gibson PG, 'A light at the end of the tunnel of inflammation in obstructive airway diseases?', Chest, 134 475-476 (2008) [C3]
DOI 10.1378/chest.08-1478
Citations Scopus - 1
2008 Pavord ID, Shaw DE, Gibson PG, Taylor DR, 'Inflammometry to assess airway diseases', The Lancet, 372 1017-1019 (2008) [C3]
DOI 10.1016/s0140-6736(08)61421-x
Citations Scopus - 41Web of Science - 34
2008 Wood LG, Garg ML, Blake RJ, Simpson JL, Gibson PG, 'Oxidized vitamin E and glutathione as markers of clinical status in asthma', Clinical Nutrition, 27 579-586 (2008) [C1]
DOI 10.1016/j.clnu.2007.12.002
Citations Scopus - 21Web of Science - 14
Co-authors Manohar Garg, Jodie Simpson, Lisa Wood
2008 Vertigan AE, Theodoros DG, Winkworth AL, Gibson PG, 'A comparison of two approaches to the treatment of chronic cough: Perceptual, acoustic, and electroglottographic outcomes', Journal of Voice, 22 581-589 (2008) [C1]
DOI 10.1016/j.jvoice.2007.01.001
Citations Scopus - 11Web of Science - 8
2008 Bateman ED, Hurd SS, Barnes PJ, Bousquet J, Drazen JM, Fitzgerald M, et al., 'Global strategy for asthma management and prevention: GINA executive summary', European Respiratory Journal, 31 143-178 (2008) [C1]
DOI 10.1183/09031936.00138707
Citations Scopus - 1343Web of Science - 1065
2008 Vertigan AE, Theodoros DG, Winkworth AL, Gibson PG, 'Acoustic and electroglottographic voice characteristics in chronic cough and paradoxical vocal fold movement', Folia Phoniatrica et Logopaedica, 60 210-216 (2008) [C1]
DOI 10.1159/000136902
Citations Scopus - 7Web of Science - 6
2007 Vertigan AE, Theodoros DG, Gibson PG, Winkworth AL, 'Voice and Upper Airway Symptoms in People With Chronic Cough and Paradoxical Vocal Fold Movement', Journal of Voice, 21 361-383 (2007) [C1]
DOI 10.1016/j.jvoice.2005.12.008
Citations Scopus - 24Web of Science - 19
2007 Chang AB, Gibson PG, Ardill J, McGarvey LPA, 'Calcitonin gene-related peptide relates to cough sensitivity in children with chronic cough', European Respiratory Journal, 30 66-72 (2007) [C1]
DOI 10.1183/09031936.00150006
Citations Scopus - 17
2007 Lovett CJ, Whitehead BF, Gibson PG, 'Eosinophilic airway inflammation and the prognosis of childhood asthma', Clinical and Experimental Allergy, 37 1594-1601 (2007) [C1]
DOI 10.1111/j.1365-2222.2007.02839.x
Citations Scopus - 21Web of Science - 15
2007 Vertigan AE, Theodoros DG, Winkworth AL, Gibson PG, 'Perceptual voice characteristics in chronic cough and paradoxical vocal fold movement', Folia Phoniatrica et Logopaedica, 59 256-267 (2007) [C1]
DOI 10.1159/000104464
Citations Scopus - 13Web of Science - 13
2007 Vertigan AE, Theodoros DG, Winkworth AL, Gibson PG, 'Chronic cough: A tutorial for speech-language pathologists', Journal of Medical Speech-Language Pathology, 15 189-206 (2007) [C1]
Citations Scopus - 7Web of Science - 6
2007 Horvat JC, Beagley KW, Wade MA, Preston JA, Hansbro NG, Hickey DK, et al., 'Neonatal chlamydial infection induces mixed T-cell responses that drive allergic airway disease', American Journal of Respiratory and Critical Care Medicine, 176 556-564 (2007) [C1]
DOI 10.1164/rccm.200607-1005OC
Citations Scopus - 49Web of Science - 45
Co-authors Jay Horvat, Nicole Hansbro, Paul Foster, Philip Hansbro
2007 Weckmann M, Collison A, Simpson JL, Kopp MV, Wark PA, Smyth MJ, et al., 'Critical link between TRAIL and CCL20 for the activation of T(H)2 cells and the expression of allergic airway disease', Nature Medicine, 13 1308-1315 (2007) [C1]
DOI 10.1038/nm1660
Citations Scopus - 69Web of Science - 63
Co-authors Nicole Hansbro, Jodie Simpson, Joerg Mattes, Paul Foster, Peter Wark
2007 Gibson PG, Taramarcaz P, McDonald VM, 'Use of omalizumab in a severe asthma clinic', Respirology, 12 S35-S44 (2007) [C1]
DOI 10.1111/j.1440-1843.2007.01047.x
Citations Scopus - 6Web of Science - 2
Co-authors Vanessa Mcdonald
2007 Grissell TV, Chang AB, Gibson PG, 'Reduced toll-like receptor 4 and substance P gene expression is associated with airway bacterial colonization in children', Pediatric Pulmonology, 42 380-385 (2007) [C1]
DOI 10.1002/ppul.20592
Citations Scopus - 26
2007 Vertigan AE, Theodoros DG, Gibson PG, Winkworth AL, 'Behaviour modification therapies for chronic cough', Chronic Respiratory Disease, 4 89-97 (2007) [C1]
DOI 10.1177/1479972307078099
Citations Scopus - 10
2007 Gibson PG, Abramson M, Wood-Baker R, Volmink J, Hensley M, Costabel U, 'Evidence-based Respiratory Medicine', Evidence-based Respiratory Medicine, 1-593 (2007)

First major evidence-based text in adult respiratory medicine. Comprehensive, authoritative summary of the best treatments for the major respiratory diseases. Compiled by speciali... [more]

First major evidence-based text in adult respiratory medicine. Comprehensive, authoritative summary of the best treatments for the major respiratory diseases. Compiled by specialists from the Cochrane Airways Management Group. Easy-to-use format, with key clinical implications summarised in each chapter. Kept up-to-date online: Compiled by specialists from the Cochrane Collaboration Airways Management Group, Evidence-based Respiratory Medicine is the first major evidence-based text in adult respiratory medicine. Providing a comprehensive summary of the best treatments for the most important respiratory diseases, some of the world's leading physicians review the evidence for a broad range of treatments using evidence-based principles. Essential information is presented in an easy-to-understand format, with the most important clinical implications summarised in each chapter. Evidence-based Respiratory Medicine tackles the big clinical questions in diagnosis and treatment, presenting treatment options which take into account the individual patient's needs. Evidence-Based Series:Evidence-based Respiratory Medicine, part of the acclaimed series BMJ Evidence-based medicine textbooks that have revolutionised clinical medicine literature, comes with a fully searchable CD-ROM of the whole text. Note: CD-ROM/DVD and other supplementary materials are not included as part of eBook file. © 2005 by Blackwell Publishing Ltd.

DOI 10.1002/9780470987377
2007 Vertigan AE, Gibson PG, Theodoros DG, Winkworth AL, 'A review of voice and upper airway function in chronic cough and paradoxical vocal cord movement', Current Opinion in Allergy and Clinical Immunology, 7 37-42 (2007) [C1]
DOI 10.1097/ACI.0b013e328012c587
Citations Scopus - 11Web of Science - 7
2007 Gibson PG, 'Long-Term Oxygen Therapy for Chronic Respiratory Failure in Chronic Obstructive Pulmonary Disease 463-471 (2007)
DOI 10.1002/9780470987377.ch35
Citations Scopus - 1
2007 Gibson PG, Powell H, 'Asthma Education 183-191 (2007)
DOI 10.1002/9780470987377.ch14
2007 Wood LG, Powell HG, Grissell TV, Nguyen TTD, Shafren D, Hensley MJ, Gibson PG, 'Persistent airway obstruction after virus infection is not associated with airway inflammation', Chest, 131 415-423 (2007) [C1]
DOI 10.1378/chest.06-1062
Citations Scopus - 8Web of Science - 7
Co-authors Lisa Wood, Michael Hensley
2007 Simpson JL, Grissell TV, Douwes J, Scott R, Boyle MJ, Gibson PG, 'Innate immune activation in neutrophilic asthma and bronchiectasis', Thorax, 62 211-218 (2007) [C1]
DOI 10.1136/thx.2006.061358
Citations Scopus - 158Web of Science - 129
Co-authors Rodney Scott, Jodie Simpson
2007 Gibson PG, 'What do non-eosinophilic asthma and airway remodelling tell us about persistent asthma?', Thorax, 62 1034-1036 (2007) [C3]
Citations Scopus - 6Web of Science - 5
2007 Gibson PG, Powell H, Ducharme FM, 'Differential effects of maintenance long-acting beta-agonist and inhaled corticosteroid on asthma control and asthma exacerbations', Journal of Allergy and Clinical Immunology, 119 344-350 (2007) [C1]
DOI 10.1016/j.jaci.2006.10.043
Citations Scopus - 64Web of Science - 53
2007 Gibson PG, Ducharme FM, Cates CJ, 'Reply', Journal of Allergy and Clinical Immunology, 120 726 (2007) [C3]
DOI 10.1016/j.jaci.2007.04.043
2007 Wark PA, Bucchieri F, Johnston SL, Gibson PG, Hamilton L, Mimica J, et al., 'IFN-gamma-induced protein 10 is a novel biomarker of rhinovirus-induced asthma exacerbations', Journal of Allergy and Clinical Immunology, 120 586-593 (2007) [C1]
DOI 10.1016/j.jaci.2007.04.046
Citations Scopus - 87Web of Science - 81
Co-authors John Attia, Joanna Latter, Peter Wark
2007 Yang Z, Yan WX, Cai H, Tedla N, Armishaw C, Di Girolamo N, et al., 'S100A12 provokes mast cell activation: A potential amplification pathway in asthma and innate immunity', Journal of Allergy and Clinical Immunology, 119 106-114 (2007) [C1]
DOI 10.1016/j.jaci.2006.08.021
Citations Scopus - 66Web of Science - 59
Co-authors Jodie Simpson
2007 Gibson PG, Ducharme FM, Cates CJ, 'Benefits of long-acting beta(2)-agonists - Reply', Journal of Allergy and Clinical Immunology, 120 726 (2007) [C3]
2007 Preston JA, Essilfie AT, Horvat JC, Wade MA, Beagley KW, Gibson PG, et al., 'Inhibition of allergic airways disease by immunomodulatory therapy with whole killed Streptococcus pneumoniae', Vaccine, 25 8154-8162 (2007) [C1]
DOI 10.1016/j.vaccine.2007.09.034
Citations Scopus - 30Web of Science - 27
Co-authors Paul Foster, Jay Horvat, Philip Hansbro
2006 Murphy VE, Clifton VL, Gibson PG, 'Asthma exacerbations during pregnancy: incidence and association with adverse pregnancy outcomes', Thorax, 61 169-176 (2006) [C1]
DOI 10.1136/thx.2005.049718
Citations Scopus - 136Web of Science - 102
Co-authors Vanessa Murphy, Vicki Clifton
2006 Wark PA, Gibson PG, 'Asthma exacerbations 3: Pathogenesis', Thorax, 61 909-915 (2006) [C1]
DOI 10.1136/thx.2005.045187
Citations Scopus - 63Web of Science - 52
Co-authors Peter Wark
2006 Fitzgerald JM, Gibson PG, 'Asthma exacerbations 4: Prevention', Thorax, 61 992-999 (2006) [C1]
DOI 10.1136/thx.2005.045195
Citations Scopus - 33Web of Science - 23
2006 Vertigan A, Theodoros D, Gibson PG, Winkworth A, 'Efficacy of Speech pathology management for chronic cough: a randomised placebo controllled trial of treatment efficacy', Thorax, 61 1065-1069 (2006) [C1]
DOI 10.1136/thx.2006.064337
Citations Scopus - 71Web of Science - 42
2006 Wood LG, Gibson PG, Garg ML, 'A review of the methodology for assessing in vivo antioxidant capacity', Journal of the Science of Food and Agriculture, 86 2057-2066 (2006) [C1]
DOI 10.1002/jsfa.2604
Citations Scopus - 58Web of Science - 41
Co-authors Lisa Wood, Manohar Garg
2006 Vertigan AE, Theodoros DG, Gibson PG, Winkworth AL, 'The Relationship Between Chronic Cough and Paradoxical Vocal Fold Movement: A Review of the Literature', Journal of Voice, 20 466-480 (2006) [C1]
DOI 10.1016/j.jvoice.2005.08.001
Citations Scopus - 26Web of Science - 21
2006 Simpson JL, Scott R, Boyle MJ, Gibson PG, 'Inflammatory subtypes in asthma: Assessment and identification using induced sputum', Respirology, 11 54-61 (2006) [C1]
DOI 10.1111/j.1440-1843.2006.00784.x
Citations Scopus - 308Web of Science - 244
Co-authors Rodney Scott, Jodie Simpson
2006 Murphy VE, Johnson RF, Wang YC, Akinsanya K, Gibson PG, Smith R, Clifton VL, 'Proteomic study of plasma proteins in pregnant women with asthma', Respirology, 11 41-48 (2006) [C1]
DOI 10.1111/j.1440-1843.2006.00782.x
Citations Scopus - 20Web of Science - 18
Co-authors Vicki Clifton, Vanessa Murphy, Roger Smith
2006 Vm M, Gibson PG, 'Asthma self-management education', Chronic Respiratory Disease, 3 29-37 (2006) [C1]
DOI 10.1191/1479972306cd090ra
Citations Scopus - 26
Co-authors Vanessa Mcdonald
2006 Vertigan AE, Gibson PG, Theodoros DG, Winkworth AL, Borgas T, Reid C, 'Involuntary glottal closure during inspiration in muscle tension dysphonia', Laryngoscope, 116 643-649 (2006) [C1]
DOI 10.1097/01.MLG.0000201906.41316.FC
Citations Scopus - 9Web of Science - 8
2006 Johnston S, Blasi F, Black P, Martin R, Farrell D, Nieman R, et al., 'The effect of telithromycin in acute exacerbations of asthma', The New England Journal of Medicine, 354 1589-1600 (2006) [C1]
DOI 10.1056/NEJMoa044080
2006 Gibson PG, 'Allergic bronchopulmonary aspergillosis', Seminars in Respiratory and Critical Care Medicine, 27 185-191 (2006) [C1]
DOI 10.1055/s-2006-939521
Citations Scopus - 40Web of Science - 32
2006 Gibson PG, Powell H, 'Initial corticosteroid therapy for asthma', Current Opinion in Pulmonary Medicine, 12 48-53 (2006) [C1]
DOI 10.1097/01.mcp.0000199808.64882.12
Citations Scopus - 4Web of Science - 2
2005 Thakkinstian A, McEvoy MA, Minelli C, Gibson PG, Hancox B, Duffy D, et al., 'Systematic review and meta-analysis of the association between beta(2)-adrenoceptor polymorphisms and asthma: A HuGE review', American Journal of Epidemiology, 162 201-211 (2005) [C1]
DOI 10.1093/aje/kwi184
Citations Scopus - 250Web of Science - 229
Co-authors Mark Mcevoy, John Attia
2005 Wood LG, Gibson PG, Garg ML, 'Circulating markers to assess nutritional therapy in cystic fibrosis', Clinica Chimica Acta, 353 13-29 (2005) [C1]
DOI 10.1016/j.cccn.2004.11.002
Citations Scopus - 8Web of Science - 6
Co-authors Lisa Wood, Manohar Garg
2005 Douwes J, LeGros G, Gibson P, Pearce N, 'On the hygiene hypothesis: Regulation down, up, or sideways? Reply', JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 115 1326-1326 (2005)
DOI 10.1016/j.jaci.2005.01.061
Citations Web of Science - 1
2005 Sigsgaard T, Heederik D, Douwes J, LeGros G, Gibson P, Pearce N, 'On the hygiene hypothesis: Regulation down, up, or sideways? [9] (multiple letters) [9]', Journal of Allergy and Clinical Immunology, 115 1325-1326 (2005)
DOI 10.1016/j.jaci.2005.01.060
Citations Scopus - 2
2005 Brannan JD, Anderson SD, Perry CP, Freed-Martens R, Lassig AR, Charlton B, et al., 'The safety and efficacy of inhaled dry powder mannitol as a bronchial provocation test for airway hyperresponsiveness: A phase 3 comparison study with hypertonic (4.5%) saline', Respiratory Research, 6 (2005)

Background: Inhaled mannitol is a new bronchial provocation test (BPT) developed to improve portability and standardisation of osmotic challenge testing. Osmotic challenge tests h... [more]

Background: Inhaled mannitol is a new bronchial provocation test (BPT) developed to improve portability and standardisation of osmotic challenge testing. Osmotic challenge tests have an advantage over the traditional methods of measuring airway hyperresponsiveness using methacholine as they demonstrate higher specificity to identify asthma and thus the need for treatment with inhaled corticosteroids (ICS). The safety and the efficacy of mannitol (M) as a BPT to measure airway hyperresponsiveness were compared to hypertonic (4.5%) saline (HS) in people both with and without signs and symptoms of asthma. Methods: A phase III, multi-centre, open label, operator-blinded, crossover design, randomised trial, with follow-up. Asthmatics and non-asthmatics (6-83yr) were recruited and 592 subjects completed the study. Mannitol was delivered using a low resistance dry powder inhaler and HS was delivered using an ultrasonic nebuliser. The FEV1 was measured 60 seconds after each dose of mannitol (5,10,20,40,80,160,160,160 mg) and after each exposure to HS (0.5,1.0,2.0,4.0,8.0 minutes). A 15% fall in FEV1 defined a positive test. Adverse events were monitored and diaries kept for 7 days following the tests. Results: Mean pre-test FEV1 (mean±SD) was 95.5±14% predicted. 296 were positive to mannitol (M+) and 322 positive to HS (HS+). A post study physician conducted clinical assessment identified 82.3% asthmatic (44% classified mild) and 17.7% non-asthmatic. Of those M+, 70.1% were taking ICS and of those mannitol negative (M-), 81.1% were taking ICS. The % fall in FEV1 for mannitol in asthmatics was 21.0%±5.7 and for the non-asthmatics, 5.5%±4.8. The median PD15 M was 148mg and PD15 HS 6.2ml. The sensitivity of M to identify HS+ was 80.7% and the specificity 86.7%. The sensitivity of M compared with the clinical assessment was 59.8% and specificity 95.2% and increased to 88.7% and 95.0% respectively when the M- subjects taking ICS were excluded. Cough was common during testing. There were no serious adverse events. The diarised events were similar for mannitol and HS, the most common being headache (17.2%M, 19%HS), pharyngolaryngeal pain (5.1%M, 3%HS), nausea (4.3%M, 3%HS), and cough (2.2%M, 2.4%HS). Conclusions: The efficacy and safety of mannitol was demonstrated in non-asthmatic and clinically diagnosed asthmatic adults and children. © 2005 Brannan et al., licensee BioMed Central Ltd.

DOI 10.1186/1465-9921-6-144
Citations Scopus - 109
2005 Thomas PS, Gibson PG, Wang H, Shah S, Henry RL, 'The relationship of exhaled nitric oxide to airway inflammation and responsiveness in children', Journal of Asthma, 42 291-295 (2005) [C1]
DOI 10.1081/JAS-200057908
Citations Scopus - 30Web of Science - 29
2005 Wood LG, Garg ML, Blake RJ, Garcia-Caraballo S, Gibson PG, 'Airway and Circulating Levels of Carotenoids in Asthma and Healthy Controls', Journal of the American College of Nutrition, 24 448-455 (2005) [C1]
Citations Scopus - 38Web of Science - 30
Co-authors Manohar Garg, Lisa Wood
2005 Gibson PG, 'Teaching old drugs new tricks: Asthma therapy adjusted by patient perception or noninvasive markers', EUROPEAN RESPIRATORY JOURNAL, 25 397-399 (2005)
DOI 10.1183/09031936.05.00002805
Citations Scopus - 17Web of Science - 12
2005 Murphy VE, Gibson PG, Smith R, Clifton VL, 'Asthma during pregnancy: mechanisms and treatment implications', European Respiratory Journal, 25 731-750 (2005) [C1]
DOI 10.1183/09031936.05.00085704
Citations Scopus - 91Web of Science - 67
Co-authors Vicki Clifton, Roger Smith, Vanessa Murphy
2005 Murphy VE, Gibson PG, Talbot PI, Kessell CG, Clifton VL, 'Asthma self-management skills and the use of asthma education during pregnancy', European Respiratory Journal, 26 435-441 (2005) [C1]
DOI 10.1183/09031936.05.00135604
Citations Scopus - 50Web of Science - 33
Co-authors Vicki Clifton, Vanessa Murphy
2005 Clifton VL, Crompton R, Read MA, Gibson PG, Smith R, Wright IM, 'Microvascular Effects of Corticotropin-Releasing Hormone in Human Skin Vary in Relation to Estrogen Concentration During the Menstrual Cycle', Journal of Endocrinology, 186 69-76 (2005) [C1]
DOI 10.1677/joe.1.06030
Citations Scopus - 14Web of Science - 11
Co-authors Ian Wright, Roger Smith, Vicki Clifton
2005 Grissell TV, Powell H, Shafren DR, Boyle MJ, Hensley MJ, Jones PD, et al., 'Interleukin-10 gene expression in acute virus-induced asthma', American Journal of Respiratory and Critical Care Medicine, 172 433-439 (2005) [C1]
DOI 10.1164/rccm.200412-1621OC
Citations Scopus - 125Web of Science - 107
Co-authors Michael Hensley
2005 Murphy VE, Johnson RF, Wang Y-C, Akinsanya K, Gibson PG, Smith R, Clifton VL, 'The Effect of Maternal Asthma on Placental and Cord Blood Protein Profiles', Society for Gynecological Investigation Journal, 12 349-355 (2005) [C1]
DOI 10.1016/j.jsgi.2005.01.024
Citations Scopus - 16Web of Science - 15
Co-authors Vanessa Murphy, Roger Smith, Vicki Clifton
2005 McDonald VM, Gibson PG, 'Inhalation-device polypharmacy in asthma', Medical Journal of Australia, 182 250-251 (2005) [C3]
Citations Scopus - 8Web of Science - 8
Co-authors Vanessa Mcdonald
2005 Simpson JL, Wood LG, Gibson PG, 'Inflammatory mediators in exhaled breath, induced sputum and saliva', Clinical & Experimental Allergy, 35 1180-1185 (2005) [C1]
DOI 10.1111/j.1365-2222.2005.02327.x
Citations Scopus - 41Web of Science - 39
Co-authors Lisa Wood, Jodie Simpson
2005 Simpson JL, Scott R, Boyle MJ, Gibson PG, 'Differential proteolytic enzyme activity in eosinophilic and neutrophilic asthma', American Journal of Respiratory and Critical Care Medicine, 172 559-565 (2005) [C1]
DOI 10.1164/rccm.200503-369OC
Citations Scopus - 99Web of Science - 88
Co-authors Rodney Scott, Jodie Simpson
2005 Wood LG, Garg ML, Simpson JL, Mori TA, Croft KD, Wark PA, Gibson PG, 'Induced sputum 8-isoprostane concentrations in inflammatory airway diseases', American Journal of Respiratory and Critical Care Medicine, 171 426-430 (2005) [C1]
DOI 10.1164/rccm.200408-1010OC
Citations Scopus - 64Web of Science - 52
Co-authors Jodie Simpson, Manohar Garg, Peter Wark, Lisa Wood
2005 Gibson PG, Powell H, Ducharme F, 'Long-acting beta2-agonists as an inhaled corticosteroid-sparing agent for chronic asthma in adults and children.', Cochrane database of systematic reviews (Online), (2005)

BACKGROUND: The addition of a long acting beta agonist (LABA) to inhaled corticosteroid (ICS) therapy can improve asthma symptoms and reduce exacerbations. The addition of LABA ma... [more]

BACKGROUND: The addition of a long acting beta agonist (LABA) to inhaled corticosteroid (ICS) therapy can improve asthma symptoms and reduce exacerbations. The addition of LABA may also have an ICS-sparing effect and permit a reduction in ICS maintenance dose. OBJECTIVES: To determine the efficacy of adding LABA to maintenance ICS therapy in reducing the requirement for ICS while maintaining control of chronic asthma. SEARCH STRATEGY: We searched the Cochrane Airways Group trials register and reference lists of articles. Date of last search: November 2004 SELECTION CRITERIA: Parallel RCTs that compared reduced dose ICS in combination with LABA vs ICS alone in asthmatics requiring daily ICS. DATA COLLECTION AND ANALYSIS: Trial quality was assessed and data were extracted independently by two reviewers. Study authors were contacted for confirmation. Trials were analysed according to the following ICS dose comparisons: a fixed moderate/high dose or a reduced/tapering dose of the same ICS. MAIN RESULTS: 19 publications describing 10 trials of adults were included in the review. Studies that compared reduced dose (mean 60% reduction) ICS/LABA combination to a fixed moderate/high dose ICS found no significant difference in severe exacerbations requiring oral corticosteroids (RR 1.0, 95%CI 0.76 to 1.32), withdrawal due to worsening asthma (RR 0.82, 95%CI 0.5 to 1.35) or airway inflammation. There were also significant improvements in FEV1 (change from baseline WMD 0.10, 95%CI 0.07 to 0.12), morning & evening PEF and percent rescue free days with LABA. Two studies provided outcomes for a reduced/tapering ICS dose comparison. More participants receiving the LABA/reduced ICS combination achieved a reduction in ICS dose reaching significance in one study. A significant reduction of 253 mcg BDP was achieved in one study. AUTHORS' CONCLUSIONS: In adults with asthma, using moderate to high maintenance doses of ICS, the addition of LABA has an ICS-sparing effect. The addition ofLABA permits more participants on minimum maintenance ICS to reduce ICS. The precise magnitude of the ICS dose reduction requires further study.

Citations Scopus - 8
2005 Murphy VE, Gibson PG, Talbot PI, Clifton VL, 'Severe asthma exacerbations during pregnancy', Obstetrics and Gynecology, 106 1046-1054 (2005) [C1]
Co-authors Vicki Clifton, Vanessa Murphy
2004 Powell HG, Gibson PG, 'Initial starting dose of inhaled corticosteroids in adults with asthma: a systematic review', Thorax, 59 1041-1045 (2004) [C1]
DOI 10.1136/thx.2004.023754
Citations Scopus - 29Web of Science - 17
2004 Gibson PG, Powell HG, 'Written action plans for asthma: an evidence-based review of the key components', Thorax, 59 94-99 (2004) [C1]
DOI 10.1136/thorax.2003.011858
Citations Scopus - 226Web of Science - 168
2004 Gibson PG, 'Atopic cough', Thorax, 59 449 (2004) [C3]
Citations Scopus - 2Web of Science - 3
2004 Douwes J, Le Gros G, Gibson PG, Pearce N, 'Can bacterial endotoxin exposure reverse atopy and atopic disease?', Journal of Allergy and Clinical Immunology, 114 1051-1054 (2004) [C1]
DOI 10.1016/j.jaci.2004.08.004
Citations Scopus - 50Web of Science - 39
2004 Taramarcaz P, Grissell TV, Borgas T, Gibson PG, 'Transient postviral vocal cord dysfunction', The Journal of Allergy and Clinical Immunology, 114 1471-1472 (2004) [C1]
DOI 10.1016/j.jaci.2004.08.038
Citations Web of Science - 19
2004 Hansbro PM, Beagley KW, Horvat JC, Gibson PG, 'Role of atypical bacterial infection of the lung in predisposition/protection of asthma', Pharmacology and Therapeutics, 101 193-210 (2004) [C1]
DOI 10.1016/j.pharmthera.2003.10.007
Citations Scopus - 66Web of Science - 54
Co-authors Philip Hansbro, Jay Horvat
2004 Henry RL, Gibson PG, Vimpani GV, Francis JL, Hazell J, 'Randomized Controlled Trial of a Teacher-Led Asthma Education Program', Pediatric Pulmonology, 38 434-442 (2004) [C1]
DOI 10.1002/ppul.20095
Citations Scopus - 27Web of Science - 18
2004 Preston JA, Beagley KW, Gibson PG, Hansbro PM, 'Genetic background affects susceptibility in nonfatal pneumococcal bronchopneumonia', Eur Respir J, 23 224-231 (2004) [C1]
DOI 10.1183/09031936.03.00081403
Citations Scopus - 21Web of Science - 17
Co-authors Philip Hansbro
2004 Gibson PG, Simpson JL, Holgate ST, Dahlén S-E, Reid DW, Champion A, et al., 'The European Network For Understanding Mechanisms Of Severe Asthma study; Host response to transmissible Pseudomonas aeruginosa; The use of computer-animation programs during spirometry in preschool children', European Respiratory Journal, 23 492-495 (2004)
DOI 10.1183/09031936.04.00132904
Co-authors Jodie Simpson
2004 Simpson JL, Timmins N, Fakes K, Talbot P, Gibson PG, 'Effect of saliva contamination on induced sputum cell counts, IL-8 and eosinophil cationic protein levels', European Respiratory Journal, 23 759-762 (2004) [C1]
DOI 10.1183/09031936.04.00043104a
Citations Scopus - 15Web of Science - 13
Co-authors Jodie Simpson
2004 Gibson PG, Simpson JL, 'The European Network For Understanding Mechanisms Of Severe Asthma study', European Respiratory Journal, 23 492-495 (2004) [C1]
DOI 10.1183/09031936.04.00132904a
Citations Scopus - 2Web of Science - 2
Co-authors Jodie Simpson
2004 Taramarcaz P, Gibson PG, 'The effectiveness of intranasal corticosteroids in combined allergic rhinitis and asthma syndrome', Clinical and Experimental Allergy, 34 1883-1889 (2004) [C1]
DOI 10.1111/j.1365-2222.2004.02130.x
Citations Scopus - 29Web of Science - 21
2004 Gibson PG, 'Review: Regular inhaled short acting B[sub2]- agonistimprove lung function in stable chronic obstructive pulmonary disease: commentary', ACP Journal Club, 140 12 (2004) [C3]
2004 Gibson PG, 'Cough is an airway itch?', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 169 1-2 (2004)
DOI 10.1164/rccm.2310009
Citations Scopus - 14Web of Science - 12
2004 Gibson PG, 'Cough is an Airway Itch', American Journal of Respiratory and Critical Care Medicine, 169 1-9 (2004) [C3]
2004 Gibson PG, 'Smokers and ex-smokers with chronic stable asthma did not respond to high dose oral corticosteroids', Evidence Based Medicine, 9 115 (2004) [C3]
2004 Powell H, Gibson PG, Thien F, 'Review: Adults who require inhaled corticosteroids benefit from a moderate starting dose', Evidence-Based Medicine, 9 178 (2004)
DOI 10.1136/ebm.9.6.178
2004 Gibson PG, 'Asthma action plans: use it or lose it', Primary Care Respiratory Journal, 13 17-18 (2004) [C3]
Citations Scopus - 10
2003 Powell H, Gibson PG, 'Review: Regular medical review is equivalent to written self management plans for optimising asthma control in adults', Evidence-Based Medicine, 8 115 (2003)
DOI 10.1136/ebm.8.4.115
2003 Simpson JL, Moric I, Wark PA, Johnston S, Gibson PG, 'Use of induced sputum for the diagnosis of influenza and infections in asthma: a comparison of diagnostic techniques', Journal of Clinical Virology, 339-346 (2003) [C1]
DOI 10.1016/S1386-6532(02)00084-7
Citations Scopus - 33Web of Science - 25
Co-authors Jodie Simpson, Peter Wark
2003 Hensley MJ, Chalmers AC, Clover K, Gibson PG, Toneguzzi R, Lewis PR, 'Symptoms of Asthma: Comparison of a Parent-Completed Retrospective Questionnaire With a Prospective Daily Symptom Diary', Pediatric Pulmonology, 36 509-513 (2003) [C1]
DOI 10.1002/ppul.10360
Citations Scopus - 20Web of Science - 18
Co-authors Anita Chalmers, Michael Hensley
2003 Gibson PG, Henry RL, Shah S, Powell H, Wang H, 'Migration to a Western Country Increases Asthma Symptoms But Not Eosinophilic Airway Inflammation', Pediatric Pulmonology, 36 209-215 (2003) [C1]
DOI 10.1002/ppul.10323
Citations Scopus - 39Web of Science - 33
2003 Powell H, Gibson PG, 'Options for self-management education for adults with asthma.', Cochrane database of systematic reviews (Online), (2003)

BACKGROUND: Asthma education and self-management are key recommendations of asthma management guidelines because they improve health outcomes. There are several different modaliti... [more]

BACKGROUND: Asthma education and self-management are key recommendations of asthma management guidelines because they improve health outcomes. There are several different modalities for the delivery of asthma self-management education. OBJECTIVES: We evaluated programmes that: 1) Optimised asthma control through inhaled corticosteroid use by regular medical review or optimised asthma control by individualised written action plans 2) Used written self-management plans based on peak expiratory flow self-monitoring compared with symptom self-monitoring 3) Compared different options for the delivery of optimal self-management programmes. SEARCH STRATEGY: We searched the Cochrane Airways Group trials register and reference lists of articles. SELECTION CRITERIA: Randomised trials of asthma self-management education interventions in adults over 16 years of age with asthma. DATA COLLECTION AND ANALYSIS: Fifteen trials met the inclusion criteria. Trial quality was assessed and data were extracted independently by two reviewers. Study authors were contacted for confirmation. MAIN RESULTS: 1) Six studies compared optimal self-management allowing self-adjustment of medications according to an individualised written action plan to adjustment of medications by a doctor. These two styles of asthma management gave equivalent effects for hospitalisation, ER visits, unscheduled doctor visits and nocturnal asthma. 2) Self-management using a written action plan based on PEF was found to be equivalent to self-management using a symptoms based written action plan in the six studies which compared these interventions. 3) Three studies compared self-management options. In one, that provided optimal therapy but tested the omission of regular review, the latter was associated with more health centre visits and sickness days. In another, comparing high and low intensity education, the latter was associated with more unscheduled doctor visits. In a third, no difference in health care utilisation or lung function was reported between verbal instruction and written action plans. REVIEWER'S CONCLUSIONS: Optimal self-management allowing for optimisation of asthma control by adjustment of medications may be conducted by either self-adjustment with the aid of a written action plan or by regular medical review. Individualised written action plans based on peak expiratory flow are equivalent to action plans based on symptoms. Reducing the intensity of self-management education or level of clinical review may reduce its effectiveness.

2003 Powell H, Gibson PG, 'Inhaled corticosteroid doses in asthma: an evidence-based approach', The Medical Journal of Australia, 178 223-225 (2003) [C1]
Citations Scopus - 73Web of Science - 55
2003 Gibson PG, Simpson JL, Hankin RG, Powell HG, Henry RL, 'Relationship between included sputum eosinophils and clinical pattern of childhood asthma', Thorax, 58 116-121 (2003) [C1]
DOI 10.1136/thorax.58.2.116
Citations Scopus - 76Web of Science - 55
Co-authors Jodie Simpson
2003 Wark PA, Hensley MJ, Saltos N, Boyle MJ, Toneguzzi R, Simpson JL, et al., 'Anti-inflammatory effect of itraconazole in stable allergic bronchopulmonary aspergillosis: A randomized controlled trial', The Journal of Allergy and Clinical Immunology, 111 952-957 (2003) [C1]
DOI 10.1067/mai.2003.1388
Citations Scopus - 158Web of Science - 116
Co-authors Jodie Simpson, Michael Hensley, Peter Wark
2003 Chang AB, Gibson PG, Masters I, Dash P, Hills B, 'The Relationship Between Inflammation and Dipalmitoyl Phosphatidycholine in Induced Sputum of Children with Asthma', Journal of Asthma, 40 63-70 (2003) [C1]
DOI 10.1081/JAS-120017208
Citations Scopus - 5Web of Science - 3
2003 Gibson PG, Wark PA, Simpson JL, Meldrum CJ, Meldrum S, Saltos N, Boyle MJ, 'Induced sputum IL-8 gene expression, neutrophil influx and MMP-9 in allergic bronchopulmonary aspergillosis', European Respiratory Journal, 21 582-588 (2003) [C1]
DOI 10.1183/09031936.03.00001803
Citations Scopus - 40Web of Science - 29
Co-authors Jodie Simpson, Peter Wark
2003 Wood LG, Gibson PG, Garg ML, 'Exhaled breath condensate contains more than only volatiles', The European Respiratory Journal, 22 1 (2003) [C3]
Citations Scopus - 5
Co-authors Manohar Garg, Lisa Wood
2003 Gibson PG, Ram FSF, Powell H, 'Asthma Education', Respiratory Medicine, 97 1036-1044 (2003) [C1]
DOI 10.1016/S0954-6111(03)00134-3
Citations Scopus - 45Web of Science - 32
2003 Gibson PG, 'Respiratory rehabilitation improves health-related quality of life in chronic obstructive pulmonary disease', ACP Journal Club, 138 43 (2003) [C3]
2003 Murphy VE, Gibson PG, Giles WB, Zakar T, Smith R, Bisits AM, et al., 'Maternal Asthma Is Associated with Reduced Female Fetal Growth', American Journal of Respiratory & Critical Care Medicine, 168 1317-1323 (2003) [C1]
DOI 10.1164/rccm.200303-374OC
Citations Scopus - 134Web of Science - 120
Co-authors Roger Smith, Vicki Clifton, Vanessa Murphy
2003 Wark PAB, Gibson PG, 'Clinical Usefulness of Inflammatory Markers in Asthma', American Journal of Respiratory & Critical Care Medicine, 2 11-19 (2003) [C1]
Citations Scopus - 23
Co-authors Peter Wark
2003 Rutherford C, Mills R, Gibson PG, Price MJ, 'Improvement in health-related quality of life with fluticasone propionate compared with budesonide or beclomethasone dipropionate in adults with severe asthma', Respirology, 8 371-375 (2003) [C1]
DOI 10.1046/j.1440-1843.2003.00488.x
Citations Scopus - 11Web of Science - 9
2002 Murphy VE, Zakar T, Smith R, Giles WB, Gibson PG, Clifton VL, 'Reduced 11 -Hydroxysteroid Dehydrogenase Type 2 Activity Is Associated with Decreased Birth Weight Centile in Pregnancies Complicated by Asthma', The Journal of Clinical Endocrinology & Metabolism, 87(4) 1660-1668 (2002) [C1]
Citations Scopus - 98Web of Science - 89
Co-authors Roger Smith, Vicki Clifton, Vanessa Murphy
2002 Gibson PG, 'Should we still give our asthmatic patients written individualised management plans? Comment', MEDICAL JOURNAL OF AUSTRALIA, 177 460-460 (2002)
2002 Thornett AM, Newbury JW, Duszynski AJ, Gibson PG, 'Should we still give our asthmatic patients written individualised management plans? (multiple letters)', Medical Journal of Australia, 177 459-460 (2002)
Citations Scopus - 1
2002 Gibson PG, 'Comment: Should we still give our asthmatic patients written individualised management plans?', The Medical Journal of Australia, 177(8) 460 (2002) [C3]
2002 Douwes J, Gibson PG, Pekkanen J, Pearce N, 'Non-eosinophilic asthma: importance and possible mechanisms', Thorax, 57 643-648 (2002) [C1]
Citations Scopus - 333Web of Science - 276
2002 Gibson PG, Fujimura M, Niimi A, 'Eosinophilic bronchitis: clinical manifestations and implications for treatment', Thorax, 57(2) 178-182 (2002) [C1]
Citations Scopus - 120
2002 Wark PA, Johnston S, Simpson JL, Hensley MJ, Gibson PG, 'Chlamydia pneumoniae immunoglobulin A reactivation and airway inflammation in acute asthma', The European Respiratory Journal, 20 834-840 (2002) [C1]
Citations Scopus - 51Web of Science - 42
Co-authors Peter Wark, Jodie Simpson, Michael Hensley
2002 Wark PA, Johnston S, Moric I, Simpson JL, Hensley MJ, Gibson PG, 'Neutrophil degranulation and cell lysis is associated with clinical severity in virus-induced asthma', The European Respiratory Journal, 19 68-75 (2002) [C1]
Citations Scopus - 224Web of Science - 180
Co-authors Michael Hensley, Peter Wark, Jodie Simpson
2002 Gibson PG, Grootendor D, Henry R, Pin I, Rytila P, Wark P, et al., 'Sputum induction in children', European Respiratory Journal, 37 44s-46s (2002) [C3]
Citations Scopus - 27Web of Science - 4
Co-authors Peter Wark
2002 Wark PA, Simpson JL, Hensley MJ, Gibson PG, 'Airway inflammation in thunderstorm asthma', Clinical and Experimental Allergy, 32 1750-1756 (2002) [C1]
Citations Scopus - 27Web of Science - 21
Co-authors Michael Hensley, Jodie Simpson, Peter Wark
2002 Mamoon H, Henry R, Stuart JE, Gibson PG, 'House dust mite allergen levels in carpeted sleeping accommodation are higher in private houses than public places', Journal of Paediatrics and Child Health, 38 568-570 (2002) [C1]
Citations Scopus - 7Web of Science - 4
Co-authors John Stuart
2002 Gibson PG, Coughlan J, Wilson A, Hensley MJ, Abramson M, Bauman A, Walters E, 'Limited (information only) patient education programs for adults with asthma', The Cochrane Library, 2 CD001005 (2002) [C3]
Citations Scopus - 17
Co-authors Amanda Wilson, Michael Hensley
2002 Richeldi L, Ferrara G, Fabbri L, Gibson PG, 'Macrolides for chronic asthma', The Cochrane Library, 1 CD002997 (2002) [C3]
2002 Haby M, Waters E, Robertson C, Gibson PG, Ducharme F, 'Interventions for educating children who have attended the emergency room for asthma', The Cochrane Library, 1 CD001290 (2002) [C3]
2002 Walters E, Walters J, Gibson PG, 'Regular treatment with long acting beta agonists versus daily regular treatment with short acting beta agonists in adults and children with stable asthma', The Cochrane Library, 4 CD003901 (2002) [C3]
2002 Gibson PG, 'Outpatient monitoring of asthma', Current Opinion in Allergy and Clinical Immunology, 2 161-166 (2002) [C1]
Citations Scopus - 7
2002 Preston JA, Beagley KW, Gibson PG, Hansbro PM, 'Development of a Pneumococcal Pneumonia Recovery Model in Mice', 3rd International Symposium on Pneumococci and Pneumococcal Diseases, n/a 91 (2002) [C3]
Co-authors Philip Hansbro
2002 Gibson PG, Powell H, Coughlan J, Wilson AJ, Hensley MJ, Abramson M, et al., 'Limited (information only) patient education programs for adults with asthma.', Cochrane database of systematic reviews (Online), (2002)

BACKGROUND: A key component of many asthma management guidelines is the recommendation for patient education and regular medical review. A number of controlled trials have been co... [more]

BACKGROUND: A key component of many asthma management guidelines is the recommendation for patient education and regular medical review. A number of controlled trials have been conducted to measure the effectiveness of asthma education programmes. These programmes improve patient knowledge, but their impact on health outcomes is less well established. At its simplest level, education is limited to the transfer of information about asthma, its causes and its treatment. This review focused on the effects of limited asthma education. OBJECTIVES: The objective of this review was to assess the effects of limited (i.e. information only) asthma education on health outcomes in adults with asthma. SEARCH STRATEGY: We searched the Cochrane Airways Group trials register and reference lists of articles. SELECTION CRITERIA: Randomised and controlled trials of individual asthma education involving information transfer only in adults over 16 years of age. DATA COLLECTION AND ANALYSIS: Trial quality was assessed and two reviewers extracted data independently. Study authors were contacted for missing information. MAIN RESULTS: Twelve trials were included. They were of variable quality. Limited asthma education did not reduce hospitalisation for asthma (weighted mean difference -0.03 average hospitalisations per person per year, 95% confidence interval -0.09 to 0.03). There was no significant effect on doctor visits, lung function and medication use. The effects on asthma symptoms were variable. There was no reduction in days lost from normal activity, but in two studies, perceived asthma symptoms did improve after limited asthma education (odds ratio 0.44, 95% confidence interval 0.26 to 0.74). In one study, limited asthma education was associated with reduced emergency department visits (reduction of -2.76 average visits per person per year, 95% confidence interval -4.34 to 1.18). REVIEWER'S CONCLUSIONS: Use of limited asthma education as it has been practiced does not appear to improve health outcomes in adults with asthma although perceived symptoms may improve. Provision of information in the emergency department may be effective, but this needs to be confirmed.

Citations Scopus - 58
Co-authors Michael Hensley
2002 Chang A, Gibson PG, 'Relationship between Cough, Cough Receptor Sensitivity and Asthma in Children', Pulmonary Pharmacology & Therapeutics, 15 287-291 (2002) [C1]
Citations Scopus - 11Web of Science - 5
2002 Simpson JL, Gibson PG, Wark PA, 'Optimization of sputum-processing methods for the measurement of interleukin-5: Effects of protease inhibition', Respirology, 7 111-116 (2002) [C1]
Citations Scopus - 8Web of Science - 10
Co-authors Jodie Simpson, Peter Wark
2002 Wood LG, Fitzgerald DA, Gibson PG, Cooper DM, Garg ML, 'Increased plasma fatty acid concentrations after respiratory exacerbations are associated with elevated oxidative stress in cystic fibrosis patients', American Journal of Clinical Nutrition: a journal reporting the practical application of our world-wide knowledge of nutrition, 75 668-675 (2002) [C1]
Citations Scopus - 37Web of Science - 30
Co-authors Manohar Garg, Lisa Wood
2002 Chang A, Harrhy V, Simpson JL, Masters I, Gibson PG, 'Cough, airway inflammation, and mild asthma exacerbation', Archives of Disease in Childhood, 86 270-275 (2002) [C1]
Citations Scopus - 24Web of Science - 22
Co-authors Jodie Simpson
2002 Powell H, Gibson PG, 'Teaching People about Asthma: the evidence', International Review of Asthma, 4(4) 88-101 (2002) [C3]
2001 Gibson PG, Simpson J, Saltos N, 'Heterogeneity of Airway Inflammation in Persistant Asthma Evidence of Neturophilic Inflammation and Increased Sputum Interleukin-8', Chest, 119 1329-1336 (2001) [C1]
Citations Scopus - 348Web of Science - 291
Co-authors Jodie Simpson
2001 Gibson PO, Simpson JL, 'IL-8 gene expression is increased in allergic bronchopulmonary aspergillosis', Respirology, 6 (2001)

Airway inflammation is allergic aspergillosis (ABPA) is typically characterised by increased eosinophils. We have recently reported increased sputum neutrophils in ABPA that corre... [more]

Airway inflammation is allergic aspergillosis (ABPA) is typically characterised by increased eosinophils. We have recently reported increased sputum neutrophils in ABPA that correlates with the extent of bronchiectasis on HRCT. In this study we sought to evaluate the role of the neutrophil chemoattractant IL-8 in ABPA. 29 adults with ABPA (20 with central bronchiectasis, ABPA-CB; 9 with serological ABPA, ABPA-S) were compared with 21 normal controls, and 9 asthmatics without Af sensitisation. Induced sputum was examined for cellular differential, IL-8 protein by ELISA and immunocytocheraistry, and IL-8 gene expression by semi-quantitative RTPCR. Sputum supernatant IL-8 was 66ng/mL in ABPA-CB, 65 in ABPA-S, 3.5ng/mL in controls and 3.6ng/mL in asthma (p<0.001 ). Sputum IL-8 correlated with sputum neutrophils (r=0.63) and FEV| % predicted (r=-0.7). IL-8 containing cells were predominantly neutrophils. IL-8mRNA levels were 108 and 24ag/mL in the ABPA groups, compared to 1.2 and 2.4ag/mL in asthma and controls (p<0.05). Conclusion: In ABPA there is elevated IL-8 gene expression and protein release, that correlates with the degree of airflow obstruction and neutrophil influx. IL-8 may be an important cytokine mediating inflammation and lung damage in ABPA.

2001 Gibson PG, 'Implementing evidence-based guidelines', Medical Journal of Australia, 174 337-338 (2001) [C2]
Citations Scopus - 8Web of Science - 6
2001 Coughlan JD, Gibson PG, Henry R, 'Medical treatment for reflux oesophagitis does not consistently improve asthma control: a systematic review', Thorax, 56 198-204 (2001) [C1]
Citations Scopus - 69
2001 Gibson PG, 'Gastro-oesophageal reflux and asthma - author's reply', Thorax, 56(11) 898 (2001) [C3]
2001 Jujimura M, Gibson PG, 'Eosinophilic airway diseases with isolated cough except for asthma', Japanese Journal of Clinical Medicine, 59 2031-2038 (2001) [C3]
2001 Gibson PG, 'Management of chronic obstructive pulmonary disease (COPD)', Australian Prescriber, 24 152-155 (2001)

The expiratory airflow obstruction that characterises chronic obstructive pulmonary disease is usually progressive over time and caused by emphysema, obliterative bronchiolitis, a... [more]

The expiratory airflow obstruction that characterises chronic obstructive pulmonary disease is usually progressive over time and caused by emphysema, obliterative bronchiolitis, and mucus hypersecretion. Stopping smoking is the only measure that slows the progression of chronic obstructive pulmonary disease, and smokers should be encouraged to stop at all stages of the disease. The effects of medication are limited, and need to be balanced against cost and adverse effects. Bronchodilators, given by puffer and spacer rather than by nebuliser, are effective. Avoid inhaled corticosteroids unless there is associated asthma. Pulmonary rehabilitation leads to important improvements in quality of life. Influenza vaccination is helpful. Comorbidity from cardiac disease and sleep disordered breathing are common and can be effectively treated. New therapies under evaluation include lung volume reduction surgery, non-invasive ventilation, and anti-inflammatory drugs.

2001 Gibson PG, 'Outcomes of the Cochrane Airways Group International Conference', Australian Prescriber, 24 78-79 (2001) [C3]
2001 Wood L, Fitzgerald D, Gibson PG, Cooper D, Collins C, Garg M, 'Oxidative Stress in Cystic Fibrosis: Dietary and Metabolic Factors', Journal of the American College of Nutrition, 20 157-165 (2001) [C1]
Citations Scopus - 64Web of Science - 50
Co-authors Manohar Garg, Lisa Wood, Clare Collins
2001 Wark PA, Simpson J, Hensley MJ, Gibson PG, 'Safety of sputum induction with isotonic saline in adults with acute severe asthma', Clinical and Experimental Allergy, 31 1745-1753 (2001) [C1]
Citations Scopus - 28Web of Science - 24
Co-authors Michael Hensley, Peter Wark, Jodie Simpson
2001 Shah S, Peat J, Mazurski E, Wang H, Sindhusake D, Bruce C, et al., 'Effect of peer led programme for asthma education in adolescents: cluster randomised controlled trial', BMJ, 322 1-5 (2001) [C1]
2001 Gibson PG, Shah S, Sindhausake D, Wang H, Peat J, Henry R, 'Peer led programme for athma education in adolescents - Author's Reply', BMJ, 323(7304) 110 (2001) [C3]
2001 Shah S, Peat JK, Mazurski EJ, Wang H, Sindhusake D, Bruce C, et al., 'Effect of peer led programme for asthma education in adolescents: cluster randomised controlled trial', BRITISH MEDICAL JOURNAL, 322 583-585 (2001)
DOI 10.1136/bmj.322.7286.583
Citations Scopus - 130Web of Science - 97
2001 Gibson PG, Shah S, Sindhusake D, Wang H, Peak JK, Henry RL, 'Peer led programme for asthma education in adolescents - Reply', BRITISH MEDICAL JOURNAL, 323 111-111 (2001)
2001 Jones PD, Hankin RG, Simpson J, Gibson PG, Henry R, 'The Tolerability, Safety, and Success of Sputum Induction and Combined Hypertonic Saline Challenge in Children', American Journal of Respiratory And Critical Care Medicine, 164 1146-1149 (2001) [C1]
Citations Scopus - 45Web of Science - 33
Co-authors Jodie Simpson
2001 Gibson PG, Saltos N, Fakes K, 'Acute Anti-Inflammatory Effects of Inhaled Budesonide in Asthma. A randomized controlled trial', American Journal of Respiratory and Critical Care Medicine, 163 32-36 (2001) [C1]
Citations Scopus - 122Web of Science - 99
2001 Gibson PG, Simpson J, Chalmers AC, Toneguzzi R, Wark PA, Wilson AJ, Hensley MJ, 'Airway Eosinophilia is associated with Wheeze but is uncommon in Children with Persistent Cough and Frequent Chest Colds', American Journal of Respiratory and Critical Care Medicine, 164 977-981 (2001) [C1]
Citations Scopus - 45Web of Science - 36
Co-authors Peter Wark, Michael Hensley, Anita Chalmers, Amanda Wilson, Jodie Simpson
2001 Clifton VL, Giles WB, Smith R, Bisits AM, Hempenstall P, Kessell C, Gibson PG, 'Alterations of Placental Vascular Function in Asthmatic Pregnancies', American Journal of Respiratory and Critical Care Medicine, 164 546-553 (2001) [C1]
Citations Scopus - 44Web of Science - 36
Co-authors Roger Smith, Vicki Clifton
2001 Wark PA, Gibson PG, Johnston S, 'Exacerbations of asthma: addressing the triggers and treatments', Monaldi Archives for Chest Disease, 56 429-435 (2001) [C1]
Co-authors Peter Wark
2001 Arnold DJ, Gibson PG, 'Prevalence of long term oral corticosteroid use and treatment for osteoporosis in chronic obstructive pulmonary disease (copd) or asthma', Respirology, 6 (2001)

Aim: To determine the prevalence of long term (>6 months) oral corticosteroid use and osteoporosis therapy (treatment or prevention) in patients hospitalised with COPD or asthma. ... [more]

Aim: To determine the prevalence of long term (>6 months) oral corticosteroid use and osteoporosis therapy (treatment or prevention) in patients hospitalised with COPD or asthma. Method: All patients admitted to hospital under the care of the respiratory service with a history of COPD or asthma were interviewed to assess their use of OCS, history of osteoporosis and therapy for osteoporosis. Results: 67 patients (mean±SD age 63±17) were enrolled, 48 with COPD and 19 with asthma. 19(28%) were on long term OCS and of these 7(10%) had a previous diagnosis of osteoporosis (5 had had a fracture and all were on osteoporosis therapy; 2 had had no fracture and 1 was on therapy). Of the 12( 18%) patients on long term OCS with no diagnosis of osteoporosis none were on preventative therapy. Of 48 patients not on long term OCS 8 had a previous diagnosis of osteoporosis but only 3 were on therapy. Overall 27 (40%) of 67 patients were on long term OCS or had a previous diagnosis of osteoporosis, 13 (19%) had had a fracture and 11 ( 16%) were on osteoporosis treatment. Conclusion: Amongst patients admitted to hospital with COPD or asthma use of long term OCS or history of osteoporosis is common, while therapy for prevention or treatment of osteoporosis is uncommon.

2001 Wark PA, Gibson PG, 'Allergic bronchopulmonary aspergillosis: New concepts of pathogenesis and treatment', Respirology, 6 1-7 (2001) [C2]
Citations Scopus - 51
Co-authors Peter Wark
2001 Berend N, Kellett B, Kent N, Sly P, Bowler S, Burdon J, et al., 'Improved safety with equivalent asthma control in adults with chronic severe asthma on high-dose fli\uticasone propionate', Respirology, 6 237-246 (2001) [C1]
2001 Preston JA, Beagley KW, Gibson PG, Hansbro PM, 'Effects of Infections by Streptococcus pneumoniae on Eosinophilic Immune Responses', Official Journal of the Australian Society for Microbiology, 22 A82 (2001) [C3]
Co-authors Philip Hansbro
2001 Wark P, Wilson AW, Gibson PG, 'Azoles for allergic bronchopulmonary aspergillosis associated with asthma.', Cochrane database of systematic reviews (Online), (2001)

BACKGROUND: Allergic Broncho-pulmonary Aspergillosis is hypersensitivity to the fungus Aspergillus fumigatus that complicates patients with asthma and cystic fibrosis. The mainsta... [more]

BACKGROUND: Allergic Broncho-pulmonary Aspergillosis is hypersensitivity to the fungus Aspergillus fumigatus that complicates patients with asthma and cystic fibrosis. The mainstay of treatment for ABPA remains oral corticosteroids, though this does not completely prevent exacerbations and may not prevent the decline in lung function. OBJECTIVES: The purpose of this review was to determine the efficacy of azoles in the treatment of Allergic Broncho-pulmonary Aspergillosis. SEARCH STRATEGY: The Cochrane Airways Group Asthma register was searched using the terms: (allergic bronchopulmonary aspergillosis OR aspergillosis OR allergic pulmonary aspergillosis OR allergic fungal and disease OR allergic mycotic and disease) AND (azole OR triazole OR itraconazole OR ketoconazole). SELECTION CRITERIA: All controlled trials that assessed the effect of azole antifungal agents compared to placebo or other standard therapy for ABPA were reviewed. Patients with cystic fibrosis were not included. DATA COLLECTION AND ANALYSIS: All identified trials were independently reviewed by both reviewers & all data collected. Trial quality was scored by the Cochrane assessment of allocation concealment & the Jadad scale of methodological quality. MAIN RESULTS: Twelve trials were identified, but only three were prospective, randomised and controlled. One demonstrated a reduction in immunological markers of disease activity and symptom scores using ketoconazole 400 mg daily for 12 month. There was no significant improvement in lung function. The other two examined the use of itraconazole for 16 weeks. In one there was a reduction in sputum eosinophils by 35% compared to 19% with placebo (p<0.01). In the same trial, the number of exacerbations requiring oral corticosteroids was 0.4 per patient with itraconazole compared with 1.3 per patient with placebo (p<0.03). Meta analysis of data from both trials showed that itraconazole treated patients were more likely to have decline in serum IgE over 25% or more (Odds Ratio 3.3; 95% confidence intervals 1.3, 8.2). REVIEWER'S CONCLUSIONS: Itraconazole modifies the immunologic activation associated with ABPA and improves clinical outcome in ABPA at least over the period of 16 weeks.

Citations Scopus - 21
2000 Gibson PG, Charpin D, 'Educating adolescents about asthma [1] (multiple letters)', Chest, 118 1514-1515 (2000)
Citations Scopus - 3
2000 Gibson PG, 'Educating Adolescents About Asthma', Chest, 118 1514-1515 (2000) [C3]
Citations Web of Science - 1
2000 Thorne R, Marshall J, Shafren D, Gibson PG, Hart I, Burns G, 'The Integrins a3B1 and a6B1 Physically and Functionally Associate with CD36 in Human Melanoma Cells', Journal of Biological Chemistry, 275 35264-35275 (2000) [C1]
Citations Scopus - 67Web of Science - 67
Co-authors Rick Thorne
2000 Wood LG, Fitzgerald DA, Gibson PG, Cooper DM, Garg ML, 'Lipid Peroxidation as Determined by Plasma Isoprostanes Is Related to Disease Severity in Mild Asthma', Lipids, 35;9 967-974 (2000) [C1]
Citations Scopus - 117Web of Science - 101
Co-authors Manohar Garg, Lisa Wood
2000 Gibson PG, 'Letter to the Editor', JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 106 1-2 (2000) [C3]
2000 Gibson PG, 'Monitoring the patient with asthma: An evidence-based approach', Journal of Allergy and Clinical Immunology, 106 17-26 (2000) [C1]
Citations Scopus - 66Web of Science - 54
2000 Gibson PG, Saltos N, Borgas T, 'Airway mast cells and eosinophils correlate with clinical severity and airway hyperresponsiveness in corticosteroid-treated asthma', Journal of Allergy and clinical Immunology, 105 752-759 (2000) [C1]
Citations Scopus - 84Web of Science - 69
2000 Jones P, Gibson PG, Henry R, 'The prevalence of asthma appears to be inversely related to the incidence of typhoid and tuberculosis: hypothesis to explain the variation in asthma prevalence around the world', Medical Hypotheses, 55 40-42 (2000) [C1]
Citations Web of Science - 15
2000 Gibson PG, Henry R, Thomas P, 'Noninvasive assessment of airway inflammation in children: induced sputum, exhaled nitric oxide, and breath condensate', European Respiratory Journal, 16 1008-1015 (2000) [C1]
Citations Scopus - 126Web of Science - 94
2000 Wark PA, Saltos N, Simpson J, Slater S, Hensley MJ, Gibson PG, 'Induced sputum easinophils and neutrophils and bronchiectasis severity in allergic bronchopulmonary aspergillosis', European Respiratory Journal, 16 1095-1101 (2000) [C1]
Citations Scopus - 56Web of Science - 41
Co-authors Peter Wark, Michael Hensley, Jodie Simpson
2000 Gibson PG, Henry R, Shah S, Toneguzzi R, Francis J, Norzila M, Davies H, 'Validation of the ISAAC video questionnaire (AVQ3.0) in adolescents from a mixed ethnic background', Clinical and Experiemental Allergy, 30 1181-1187 (2000) [C1]
Citations Scopus - 48Web of Science - 32
2000 Gibson PG, 'Commentary on "Glucocorticoids reduced short-term treatment failure in exacerbations of chronic obstructive pulmonary disease". Comment on: Niewoehner DE, Erbland ML, Deupree RH et al. Effect of systemic glucocorticoids on exacerbations of chronic obstruc', ACP JOURNAL CLUB, 132 14 (2000) [C3]
2000 Gibson PG, Henry R, Coughlan J, 'Review: Treatment of gastroesophageal reflux does not improve asthma outcomes', ACP Journal Club, 132 15 (2000) [C3]
2000 Norzila M, Fakes K, Henry R, Simpson J, Gibson PG, 'Interleukin-8 secretion and neutrophil recruitment accompanies induced sputum eosinophil activation in children with acute asthma', American Journal of respiratory and Critical Care Medicine, 161 769-774 (2000) [C1]
Citations Web of Science - 140
Co-authors Jodie Simpson
2000 Wark PA, Gibson PG, Fakes K, 'Induced sputum eosinophils in the assessment of asthma and chronic cough*', Respirology, 5 51-57 (2000) [C1]
Citations Scopus - 19
Co-authors Peter Wark
2000 Gibson PG, 'European Respiratory Society Annual Congress', I Drugs, 3 56-58 (2000) [C3]
2000 Wark PA, Wilson A, Gibson PG, 'Azoles for allergic bronchopulmonary aspergillosis', The Cochrane Library, 1-9 (2000) [C1]
Co-authors Peter Wark
2000 Gibson PG, Coughlan J, Wilson AJ, Abramson M, Bauman A, Hensley MJ, Walters EH, 'Self-management education and regular practitioner review for adults with asthma.', Cochrane database of systematic reviews (Online : Update Software), CD001117 (2000)

BACKGROUND: A key component of many asthma management guidelines is the recommendation for patient education and regular medical review. A number of controlled trials have been co... [more]

BACKGROUND: A key component of many asthma management guidelines is the recommendation for patient education and regular medical review. A number of controlled trials have been conducted to measure the effectiveness of asthma education programmes. These programmes improve patient knowledge, but their impact on health outcomes is less well established. This review was conducted to examine the strength of evidence supporting Step 6 of the Australian Asthma Management Plan: "Educate and Review Regularly"; to test whether health outcomes are influenced by education and self-management programmes. OBJECTIVES: The objective of this review was to assess the effects of asthma self-management programmes, when coupled with regular health practitioner review, on health outcomes in adults with asthma. SEARCH STRATEGY: We searched the Cochrane Airways Group trials register and reference lists of articles. SELECTION CRITERIA: Randomised trials of self-management education in adults over 16 years of age with asthma. DATA COLLECTION AND ANALYSIS: Trial quality was assessed and data were extracted independently by two reviewers. Study authors were contacted for confirmation. MAIN RESULTS: Twenty-five trials were included. Self-management education was compared with usual care in 22 studies. Self-management education reduced hospitalisations (odds ratio 0.57, 95% confidence interval 0.38 to 0.88); emergency room visits (odds ratio 0.71, 95% confidence interval (0.57 to 0.90); unscheduled visits to the doctor (odds ratio 0.57, 95% confidence interval 0.40 to 0.82); days off work or school (odds ratio 0.55, 95% confidence interval 0.38 to 0. 79); and nocturnal asthma (odds ratio 0.53, 95% confidence interval 0.39 to 0.72). Measures of lung function were little changed. Self-management programmes that involved a written action plan showed a greater reduction in hospitalisation than those that did not (odds ratio 0.35, 95% confidence interval 0.18 to 0.68). People who managed their asthma by self-adjustment of their medications using an individualised written plan had better lung function than those whose medications were adjusted by a doctor. REVIEWER'S CONCLUSIONS: Training in asthma self-management which involves self-monitoring by either peak expiratory flow or symptoms, coupled with regular medical review and a written action plan appears to improve health outcomes for adults with asthma. Training programmes which enable people to adjust their medication using a written action plan appear to be more effective than other forms of asthma self-management.

Citations Scopus - 62
Co-authors Michael Hensley, Amanda Wilson
2000 Gibson PG, Henry RL, Coughlan JL, 'Gastro-oesophageal reflux treatment for asthma in adults and children.', Cochrane database of systematic reviews (Online : Update Software), (2000)

BACKGROUND: Asthma and gastro-oesophageal reflux are both common medical conditions and often co-exist. Studies have shown conflicting results concerning the effects of lower oeso... [more]

BACKGROUND: Asthma and gastro-oesophageal reflux are both common medical conditions and often co-exist. Studies have shown conflicting results concerning the effects of lower oesophageal acidification as a trigger of asthma. Furthermore, asthma might precipitate gastro-oesophageal reflux. Thus a temporal association between the two does not establish that gastro-oesophageal reflux triggers asthma. Randomised trials of a number of treatments for gastro-oesophageal reflux in asthma have been conducted, with conflicting results. OBJECTIVES: The objective of this review was to evaluate the effectiveness of treatments for gastro-oesophageal reflux in terms of their benefit on asthma. SEARCH STRATEGY: The Cochrane Airways Group trials register, review articles and reference lists of articles were searched. SELECTION CRITERIA: Randomised controlled trials of treatment for oesophageal reflux in adults and children with a diagnosis of both asthma and gastro-oesophageal reflux. DATA COLLECTION AND ANALYSIS: Trial quality and data extraction were carried out by two independent reviewers. Authors were contacted for confirmation or more data. MAIN RESULTS: Nine trials met the inclusion criteria. Interventions included proton pump inhibitors (n=3), histamine antagonists (n=5), surgery (n=1) and conservative management (n=1). Treatment duration ranged from 1 week to 6 months. A temporal association between asthma and gastro-oesophageal reflux was investigated in 4 trials and found to be present in a proportion of participants in these trials. Anti-reflux treatment did not consistently improve lung function, asthma symptoms, nocturnal asthma or the use of asthma medications. REVIEWER'S CONCLUSIONS: In asthmatic subjects with gastro-oesophageal reflux, (but who were not recruited specifically on the basis of reflux-associated respiratory symptoms), there was no overall improvement in asthma following treatment for gastro-oesophageal reflux. Subgroups of patients may gain benefit, but it appears difficult to predict responders.

2000 Gibson PG, Coughlan J, Wilson AJ, Hensley MJ, Abramson M, Bauman A, Walters EH, 'Limited (information only) patient education programs for adults with asthma.', Cochrane database of systematic reviews (Online : Update Software), (2000)

BACKGROUND: A key component of many asthma management guidelines is the recommendation for patient education and regular medical review. A number of controlled trials have been co... [more]

BACKGROUND: A key component of many asthma management guidelines is the recommendation for patient education and regular medical review. A number of controlled trials have been conducted to measure the effectiveness of asthma education programmes. These programmes improve patient knowledge, but their impact on health outcomes is less well established. At its simplest level, education is limited to the transfer of information about asthma, its causes and its treatment. This review focused on the effects of limited asthma education. OBJECTIVES: The objective of this review was to assess the effects of limited (i.e. information only) asthma education on health outcomes in adults with asthma. SEARCH STRATEGY: We searched the Cochrane Airways Group trials register and reference lists of articles. SELECTION CRITERIA: Randomised and controlled trials of individual asthma education involving information transfer only in adults over 16 years of age. DATA COLLECTION AND ANALYSIS: Trial quality was assessed and data were extracted independently by two reviewers. Study authors were contacted for missing information. MAIN RESULTS: Eleven trials were included. They were of variable quality. Limited asthma education did not reduce hospitalisation for asthma (weighted mean difference -0.03 average hospitalisations per person per year, 95% confidence interval -0.09 to 0.03). There was no effect on doctor visits, lung function and medication use. The effects on asthma symptoms were variable. There was no reduction in days lost from normal activity, but perceived asthma symptoms did improve after limited asthma education (odds ratio 0.40, 95% confidence interval 0.18 to 0.86). In one study, limited asthma education was associated with reduced emergency department visits (weighted mean difference -2.76 average visits per person per year, 95% confidence interval -4.34 to 1.18). REVIEWER'S CONCLUSIONS: Use of limited asthma education as it has been practiced does not appear to improve health outcomes in adults with asthma. However the use of information in the emergency department may be effective, but this needs to be confirmed.

Citations Scopus - 31
Co-authors Amanda Wilson, Michael Hensley
2000 Gibson PG, Coughlan J, Wilson AJ, Hensley MJ, Abramson M, Bauman A, Walters EH, 'Limited (information only) patient education programs for adults with asthma.', Cochrane database of systematic reviews (Online), (2000)

BACKGROUND: A key component of many asthma management guidelines is the recommendation for patient education and regular medical review. A number of controlled trials have been co... [more]

BACKGROUND: A key component of many asthma management guidelines is the recommendation for patient education and regular medical review. A number of controlled trials have been conducted to measure the effectiveness of asthma education programmes. These programmes improve patient knowledge, but their impact on health outcomes is less well established. At its simplest level, education is limited to the transfer of information about asthma, its causes and its treatment. This review focused on the effects of limited asthma education. OBJECTIVES: The objective of this review was to assess the effects of limited (i.e. information only) asthma education on health outcomes in adults with asthma. SEARCH STRATEGY: We searched the Cochrane Airways Group trials register and reference lists of articles. SELECTION CRITERIA: Randomised and controlled trials of individual asthma education involving information transfer only in adults over 16 years of age. DATA COLLECTION AND ANALYSIS: Trial quality was assessed and data were extracted independently by two reviewers. Study authors were contacted for missing information. MAIN RESULTS: Eleven trials were included. They were of variable quality. Limited asthma education did not reduce hospitalisation for asthma (weighted mean difference -0.03 average hospitalisations per person per year, 95% confidence interval -0.09 to 0.03). There was no effect on doctor visits, lung function and medication use. The effects on asthma symptoms were variable. There was no reduction in days lost from normal activity, but perceived asthma symptoms did improve after limited asthma education (odds ratio 0.40, 95% confidence interval 0.18 to 0.86). In one study, limited asthma education was associated with reduced emergency department visits (weighted mean difference -2.76 average visits per person per year, 95% confidence interval -4.34 to 1.18). REVIEWER'S CONCLUSIONS: Use of limited asthma education as it has been practiced does not appear to improve health outcomes in adults with asthma. However the use of information in the emergency department may be effective, but this needs to be confirmed.

Co-authors Michael Hensley
2000 Gibson PG, Coughlan J, Wilson AJ, Abramson M, Bauman A, Hensley MJ, Walters EH, 'Self-management education and regular practitioner review for adults with asthma.', Cochrane database of systematic reviews (Online), (2000)

BACKGROUND: A key component of many asthma management guidelines is the recommendation for patient education and regular medical review. A number of controlled trials have been co... [more]

BACKGROUND: A key component of many asthma management guidelines is the recommendation for patient education and regular medical review. A number of controlled trials have been conducted to measure the effectiveness of asthma education programmes. These programmes improve patient knowledge, but their impact on health outcomes is less well established. This review was conducted to examine the strength of evidence supporting Step 6 of the Australian Asthma Management Plan: "Educate and Review Regularly"; to test whether health outcomes are influenced by education and self-management programmes. OBJECTIVES: The objective of this review was to assess the effects of asthma self-management programmes, when coupled with regular health practitioner review, on health outcomes in adults with asthma. SEARCH STRATEGY: We searched the Cochrane Airways Group trials register and reference lists of articles. SELECTION CRITERIA: Randomised trials of self-management education in adults over 16 years of age with asthma. DATA COLLECTION AND ANALYSIS: Trial quality was assessed and data were extracted independently by two reviewers. Study authors were contacted for confirmation. MAIN RESULTS: Twenty-five trials were included. Self-management education was compared with usual care in 22 studies. Self-management education reduced hospitalisations (odds ratio 0.57, 95% confidence interval 0.38 to 0.88); emergency room visits (odds ratio 0.71, 95% confidence interval (0.57 to 0.90); unscheduled visits to the doctor (odds ratio 0.57, 95% confidence interval 0.40 to 0.82); days off work or school (odds ratio 0.55, 95% confidence interval 0.38 to 0. 79); and nocturnal asthma (odds ratio 0.53, 95% confidence interval 0.39 to 0.72). Measures of lung function were little changed. Self-management programmes that involved a written action plan showed a greater reduction in hospitalisation than those that did not (odds ratio 0.35, 95% confidence interval 0.18 to 0.68). People who managed their asthma by self-adjustment of their medications using an individualised written plan had better lung function than those whose medications were adjusted by a doctor. REVIEWER'S CONCLUSIONS: Training in asthma self-management which involves self-monitoring by either peak expiratory flow or symptoms, coupled with regular medical review and a written action plan appears to improve health outcomes for adults with asthma. Training programmes which enable people to adjust their medication using a written action plan appear to be more effective than other forms of asthma self-management.

Co-authors Michael Hensley
2000 Gibson PG, Henry RL, Coughlan JL, 'Gastro-oesophageal reflux treatment for asthma in adults and children.', Cochrane database of systematic reviews (Online), (2000)

BACKGROUND: Asthma and gastro-oesophageal reflux are both common medical conditions and often co-exist. Studies have shown conflicting results concerning the effects of lower oeso... [more]

BACKGROUND: Asthma and gastro-oesophageal reflux are both common medical conditions and often co-exist. Studies have shown conflicting results concerning the effects of lower oesophageal acidification as a trigger of asthma. Furthermore, asthma might precipitate gastro-oesophageal reflux. Thus a temporal association between the two does not establish that gastro-oesophageal reflux triggers asthma. Randomised trials of a number of treatments for gastro-oesophageal reflux in asthma have been conducted, with conflicting results. OBJECTIVES: The objective of this review was to evaluate the effectiveness of treatments for gastro-oesophageal reflux in terms of their benefit on asthma. SEARCH STRATEGY: The Cochrane Airways Group trials register, review articles and reference lists of articles were searched. SELECTION CRITERIA: Randomised controlled trials of treatment for oesophageal reflux in adults and children with a diagnosis of both asthma and gastro-oesophageal reflux. DATA COLLECTION AND ANALYSIS: Trial quality and data extraction were carried out by two independent reviewers. Authors were contacted for confirmation or more data. MAIN RESULTS: Nine trials met the inclusion criteria. Interventions included proton pump inhibitors (n=3), histamine antagonists (n=5), surgery (n=1) and conservative management (n=1). Treatment duration ranged from 1 week to 6 months. A temporal association between asthma and gastro-oesophageal reflux was investigated in 4 trials and found to be present in a proportion of participants in these trials. Anti-reflux treatment did not consistently improve lung function, asthma symptoms, nocturnal asthma or the use of asthma medications. REVIEWER'S CONCLUSIONS: In asthmatic subjects with gastro-oesophageal reflux, (but who were not recruited specifically on the basis of reflux-associated respiratory symptoms), there was no overall improvement in asthma following treatment for gastro-oesophageal reflux. Subgroups of patients may gain benefit, but it appears difficult to predict responders.

2000 Wilson AJ, Gibson PG, Coughlan J, 'Long acting beta-agonists versus theophylline for maintenance treatment of asthma.', Cochrane database of systematic reviews (Online), (2000)

BACKGROUND: Theophylline and long acting beta2-agonists are bronchodilators used for the management of persistent asthma symptoms, especially nocturnal asthma. They represent diff... [more]

BACKGROUND: Theophylline and long acting beta2-agonists are bronchodilators used for the management of persistent asthma symptoms, especially nocturnal asthma. They represent different classes of drug with differing side-effect profiles. OBJECTIVES: To assess the comparative efficacy, safety and side-effects of long-acting beta-agonists and theophylline in the maintenance treatment of asthma. SEARCH STRATEGY: Randomised, controlled trials (RCTs) were identified using the Cochrane Airways Group register. The register was searched using the following terms: asthma and theophylline and long acting beta-agonist or formoterol or foradile or eformoterol or salmeterol or bambuterol or bitolterol. Titles and abstracts were then screened to identify potentially relevant studies. The bibliography of each RCT was searched for additional RCTs. Authors of identified RCTs were contacted for other relevant published and unpublished studies. SELECTION CRITERIA: All included studies were RCTs involving adults and children with clinical evidence of asthma. These studies must have compared oral sustained release and/or dose adjusted theophylline with an inhaled long-acting beta-agonist. DATA COLLECTION AND ANALYSIS: Potentially relevant trials, identified by screening titles and/or abstracts, were obtained. Two reviewers independently assessed full text versions of these trials to decided whether the trial should be included in the review, and assessed its methodological quality. Where there was disagreement between reviewers, this was resolved by consensus, or reference to a third party. Data were extracted by two independent reviewers. Inter-rater reliability was assessed by simple agreement. Study authors were contacted to clarify randomisation methods, provide missing data, verify the data extracted and identify unpublished studies. Relevant pharmaceutical manufacturers were also contacted. MAIN RESULTS: Six trials met the inclusion criteria. Five used salmeterol and one, biltoterol. They were of varying quality. There was a trend for salmeterol to improve FEV1 more than theophylline in three studies and salmeterol use was associated with more symptom free nights. Bitolterol, used in only one study, was reported to be less effective than theophylline. Subjects taking salmeterol experienced fewer adverse events than those using theophylline (Relative Risk 0.38; 95%Confidence Intervals 0.25, 0.57). Significant reductions were reported for central nervous system adverse events (Relative Risk 0.51; 95%Confidence Intervals 0.30, 0.88) and gastrointestinal adverse events (Relative Risk 0.32; 95%Confidence Intervals 0.17, 0.59). REVIEWER'S CONCLUSIONS: Salmeterol may be more effective than theophylline in reducing asthma symptoms including night waking and improving lung function. More adverse events occurred in subjects using theophylline when compared to salmeterol.

Citations Scopus - 14
Co-authors Amanda Wilson
2000 Wark P, Wilson AW, Gibson PG, 'Azoles for allergic bronchopulmonary aspergillosis.', Cochrane database of systematic reviews (Online), (2000)

BACKGROUND: Allergic Broncho-pulmonary Aspergillosis (ABPA) is hypersensitivity to the fungus Aspergillus Fumigatus that complicates patients with asthma and cystic fibrosis. The ... [more]

BACKGROUND: Allergic Broncho-pulmonary Aspergillosis (ABPA) is hypersensitivity to the fungus Aspergillus Fumigatus that complicates patients with asthma and cystic fibrosis. The condition usually results in an increase in symptoms, a greater reliance on corticosteroids to control the disease process and may lead to a progressive decline in lung function. The mainstay of treatment for ABPA remains oral corticosteroids, though this does not completely prevent exacerbations and may not prevent the decline in lung function. OBJECTIVES: The purpose of this review is to determine the efficacy of azoles in the treatment of ABPA SEARCH STRATEGY: An initial search was carried out using the Cochrane Airways Group Asthma RCT register. The register was searched using the following terms: (asthma or wheeze) and (allergic bronchopulmonary aspergillosis or aspergillosis or allergic pulmonary aspergillosis or allergic fungal and disease or allergic mycotic and disease) and (azole or triazole or itraconazole or ketoconazole). SELECTION CRITERIA: All controlled trials that assessed the effect of azole antifungal agents compared to placebo or other standard, for any duration or dose regimen in subjects with ABPA of any age or severity were reviewed. Studies in languages other than English were included. DATA COLLECTION AND ANALYSIS: All identified trials were independently reviewed by both reviewers & all data collected. Trial quality was scored by the Cochrane assessment of allocation concealment & the Jadad scale of methodological quality. MAIN RESULTS: A total of 11 trials were identified concerning the use of azoles in ABPA. Only two prospective controlled trials were identified. The first trial examined the use of Ketoconazole 400 mg daily for 12 months and demonstrated a reduction in immunological markers of disease activity and symptom scores, there was no significant improvement in lung function. The other trial examined the use of itraconazole for 16 weeks. This demonstrated a reduction in corticosteroid usage, an improvement in immunological markers, an improvement in pulmonary function and exercise tolerance. This study was only available as an abstract and limited details were available. REVIEWER'S CONCLUSIONS: There is insufficient information available to recommend the use of azole anti-fungal agents in the routine treatment of patients with ABPA.

Co-authors Peter Wark
2000 Hensley M, Coughlan JL, Gibson P, 'Lung volume reduction surgery for diffuse emphysema.', Cochrane database of systematic reviews (Online : Update Software), (2000)

BACKGROUND: Lung volume reduction surgery (LVRS) has been re-introduced for treating patients with severe diffuse emphysema. OBJECTIVES: To assemble evidence from randomised contr... [more]

BACKGROUND: Lung volume reduction surgery (LVRS) has been re-introduced for treating patients with severe diffuse emphysema. OBJECTIVES: To assemble evidence from randomised controlled trials for the effectiveness of LVRS, and identify optimal surgical techniques, those patients who benefit most and those for whom it should be avoided. SEARCH STRATEGY: Randomised controlled trials were identified using the Cochrane Airways Group COPD register using the terms: emphysema AND (emphysema surgery OR lung volume reduction surgery OR LVRS OR volume reduction surgery OR pneumectomy OR reduction pneumoplasty OR lung reduction surgery). The Cochrane Controlled Clinical Trials Register was also searched using these terms. SELECTION CRITERIA: Randomised controlled trials that studied the safety and efficacy of LVRS in patients with diffuse emphysema were included. Studies were excluded if they investigated giant or bullous emphysema. DATA COLLECTION AND ANALYSIS: Two independent reviewers assessed trials for inclusion and extracted data. MAIN RESULTS: Only one randomised trial of LVRS for diffuse emphysema was identified. This compared stapled unilateral thoracoscopic lung reduction coupled with bovine pericardium reinforcement with a unilateral neodymium:yttrium aluminium garnet laser contact reduction. A total of 72 patients were studied. Both arms included post-operative rehabilitation and appeared to be well matched at randomisation. Improvement in FEV1 & FVC at six months was significantly greater in the staple treated group (p < 0.01 & p < 0. 07 respectively), but absolute increases were small. Need for supplemental oxygen was reduced significantly more in the staple treated group; Peto Odds Ratio (OR) 4.05; 95% confidence interval (CI) 1.40, 11.71. Quality of life improved more in the staple treated group (OR 5.36; 95% CI 2.13,13.47). The rate of delayed pneumothorax in the laser treated group was significantly higher (OR 10.46; 95% CI 1.98, 55.30). REVIEWER'S CONCLUSIONS: There is no randomised controlled trial evidence concerning the efficacy of LVRS for diffuse emphysema compared to optimal conservative medical therapy. Stapling is more effective than laser resection and has a lower complication rate. LVRS should not be applied routinely until results of large trials currently underway become available.

Citations Scopus - 2
2000 Davies H, Olson L, Gibson P, 'Methotrexate as a steroid sparing agent for asthma in adults.', Cochrane database of systematic reviews (Online : Update Software), (2000)

BACKGROUND: Sustained oral corticosteroid use can lead to complications, so there is interest in identifying agents that can reduce oral steroid use in people with asthma. Methotr... [more]

BACKGROUND: Sustained oral corticosteroid use can lead to complications, so there is interest in identifying agents that can reduce oral steroid use in people with asthma. Methotrexate has attracted attention as a possible steroid sparing agent in patients with chronic oral steroid dependent asthma. OBJECTIVES: The objective of this review was to assess the effects of adding methotrexate to oral corticosteroids in adults with stable asthma who are dependent on oral corticosteroids. SEARCH STRATEGY: The Cochrane Airways Group trials register and reference lists of identified articles were searched. SELECTION CRITERIA: Randomised trials of the addition of methotrexate compared with placebo in adult steroid dependent asthmatics. Duration of therapy needed to be at least 12 weeks. DATA COLLECTION AND ANALYSIS: Trial quality was assessed and data extraction was carried out by two reviewers independently. Study authors were contacted for missing information. MAIN RESULTS: Ten trials involving a total of 185 people were included. Study design and quality, corticosteroid dosages and outcomes varied widely. There was a reduction in oral corticosteroid dose favouring methotrexate in parallel trials (weighted mean difference -4.1 mg per day, 95% confidence interval -6.8 to -1.3) and also in cross-over trials (weighted mean difference -2.9 mg per day, 95% confidence interval -5.9 to -0.2). There was no difference between methotrexate and placebo for forced expiratory volume in one minute (weighted mean difference 0.12 litre, 95% confidence interval -0.21 to 0.45). Hepatotoxicity was a common adverse effect with methotrexate compared to placebo (odds ratio 6.9, 95% confidence interval 3.1 to 15.5). REVIEWER'S CONCLUSIONS: Methotrexate may have a small steroid sparing effect in adults with asthma who are dependent on oral corticosteroids. However, the overall reduction in daily steroid use is probably not large enough to reduce steroid-induced adverse effects. This small potential to reduce the impact of steroid side-effects is probably insufficient to offset the adverse effects of methotrexate.

2000 Davies H, Olson L, Gibson P, 'Methotrexate as a steroid sparing agent for asthma in adults.', Cochrane database of systematic reviews (Online), (2000)

BACKGROUND: Sustained oral corticosteroid use can lead to complications, so there is interest in identifying agents that can reduce oral steroid use in people with asthma. Methotr... [more]

BACKGROUND: Sustained oral corticosteroid use can lead to complications, so there is interest in identifying agents that can reduce oral steroid use in people with asthma. Methotrexate has attracted attention as a possible steroid sparing agent in patients with chronic oral steroid dependent asthma. OBJECTIVES: The objective of this review was to assess the effects of adding methotrexate to oral corticosteroids in adults with stable asthma who are dependent on oral corticosteroids. SEARCH STRATEGY: The Cochrane Airways Group trials register and reference lists of identified articles were searched. SELECTION CRITERIA: Randomised trials of the addition of methotrexate compared with placebo in adult steroid dependent asthmatics. Duration of therapy needed to be at least 12 weeks. DATA COLLECTION AND ANALYSIS: Trial quality was assessed and data extraction was carried out by two reviewers independently. Study authors were contacted for missing information. MAIN RESULTS: Ten trials involving a total of 185 people were included. Study design and quality, corticosteroid dosages and outcomes varied widely. There was a reduction in oral corticosteroid dose favouring methotrexate in parallel trials (weighted mean difference -4.1 mg per day, 95% confidence interval -6.8 to -1.3) and also in cross-over trials (weighted mean difference -2.9 mg per day, 95% confidence interval -5.9 to -0.2). There was no difference between methotrexate and placebo for forced expiratory volume in one minute (weighted mean difference 0.12 litre, 95% confidence interval -0.21 to 0.45). Hepatotoxicity was a common adverse effect with methotrexate compared to placebo (odds ratio 6.9, 95% confidence interval 3.1 to 15.5). REVIEWER'S CONCLUSIONS: Methotrexate may have a small steroid sparing effect in adults with asthma who are dependent on oral corticosteroids. However, the overall reduction in daily steroid use is probably not large enough to reduce steroid-induced adverse effects. This small potential to reduce the impact of steroid side-effects is probably insufficient to offset the adverse effects of methotrexate.

Citations Scopus - 43
2000 Hensley M, Coughlan JL, Gibson P, 'Lung volume reduction surgery for diffuse emphysema.', Cochrane database of systematic reviews (Online), (2000)

BACKGROUND: Lung volume reduction surgery (LVRS) has been re-introduced for treating patients with severe diffuse emphysema. OBJECTIVES: To assemble evidence from randomised contr... [more]

BACKGROUND: Lung volume reduction surgery (LVRS) has been re-introduced for treating patients with severe diffuse emphysema. OBJECTIVES: To assemble evidence from randomised controlled trials for the effectiveness of LVRS, and identify optimal surgical techniques, those patients who benefit most and those for whom it should be avoided. SEARCH STRATEGY: Randomised controlled trials were identified using the Cochrane Airways Group COPD register using the terms: emphysema AND (emphysema surgery OR lung volume reduction surgery OR LVRS OR volume reduction surgery OR pneumectomy OR reduction pneumoplasty OR lung reduction surgery). The Cochrane Controlled Clinical Trials Register was also searched using these terms. SELECTION CRITERIA: Randomised controlled trials that studied the safety and efficacy of LVRS in patients with diffuse emphysema were included. Studies were excluded if they investigated giant or bullous emphysema. DATA COLLECTION AND ANALYSIS: Two independent reviewers assessed trials for inclusion and extracted data. MAIN RESULTS: Only one randomised trial of LVRS for diffuse emphysema was identified. This compared stapled unilateral thoracoscopic lung reduction coupled with bovine pericardium reinforcement with a unilateral neodymium:yttrium aluminium garnet laser contact reduction. A total of 72 patients were studied. Both arms included post-operative rehabilitation and appeared to be well matched at randomisation. Improvement in FEV1 & FVC at six months was significantly greater in the staple treated group (p < 0.01 & p < 0. 07 respectively), but absolute increases were small. Need for supplemental oxygen was reduced significantly more in the staple treated group; Peto Odds Ratio (OR) 4.05; 95% confidence interval (CI) 1.40, 11.71. Quality of life improved more in the staple treated group (OR 5.36; 95% CI 2.13,13.47). The rate of delayed pneumothorax in the laser treated group was significantly higher (OR 10.46; 95% CI 1.98, 55.30). REVIEWER'S CONCLUSIONS: There is no randomised controlled trial evidence concerning the efficacy of LVRS for diffuse emphysema compared to optimal conservative medical therapy. Stapling is more effective than laser resection and has a lower complication rate. LVRS should not be applied routinely until results of large trials currently underway become available.

1999 McNamara T, Zeng XP, Faraguna LA, Gibson P, Scicchitano R, Holmes M, 'Defensin mRNA is expressed in cells from induced sputum in asthmatics', Respirology, 4 (1999)

Defensins are small antimicrobial peptides which in addition to their role in host defense, have a number of functions, including cytotoxicity which may contribute to airways epit... [more]

Defensins are small antimicrobial peptides which in addition to their role in host defense, have a number of functions, including cytotoxicity which may contribute to airways epithelial damage in asthma. As part of a large multicentre trial, we had the opportunity to examine induced sputum obtained from a group of asthmatic subjects. Hypothesis: Human defensin gene expression is a marker of airway inflammation and asthma severity. Methods: Induced sputum was collected from 11 asthmatics and processed using the plug selection method. Total and differential cell counts were determined before isolation of total RNA. Defensin mRNA expression was analysed using reverse transcription and competitive polymerase chain reaction. Data were analysed using regression analysis; significance p<0.05. Results: Induced sputum samples yielded an average cell viability of 84.5 ± 2.5%. The differential cell count was (mean % ±SEM) neutrophils 42.1 ± 6.0, macrophages 55.1 ±5.8, eosinophils 1.5±0.6, epithelial cells 0.7±0.2, lymphocytes 0.7±0.2, mast cells 0.1 ±0.0 and squamous cells 4.0±1.0. Human ct-defensins (Human Neutrophil Peptide 1-3; HNP1-3), human beta defensin-1 (hBD-1) and human beta defensin-2 (hBD-2) mRNA expression was detected in all samples. Defensin gene expression did not correlate significantly with % predicted FEVi, % predicted FVC, FEWFVC or PD to hypertonic saline. Defensin expression was not correlated significantly with the % of neutrophils or macrophages in sputum. Conclusions: Defensin mRNA expressed in sputum cells obtained from asthmatics and the relationship with parameters of asthma severity and airways inflammation needs further investigation.

1999 Shah S, Mazurski E, Wang H, Henry R, Bauman A, Peat JK, Gibson P, 'Asthma knowledge and morbidity in rural adolescents', Respirology, 4 (1999)

The burden of illness caused by asthma in rural adolescents is poorly defined. We sought to establish knowledge of asthma self-management and various aspects of asthma morbidity i... [more]

The burden of illness caused by asthma in rural adolescents is poorly defined. We sought to establish knowledge of asthma self-management and various aspects of asthma morbidity in high school students in rural NSW, prior to the implementation of a peer-led asthma educational program. Methods: Students from years 7 and 10 in six high schools (n =1379, 91% response rate) in Tamworth completed video questionnaires to measure asthma prevalence (ISAAC) and asthma self management behaviour'. Students who reported wheezing in the last year (n=280, 86% response rate) completed questionnaires for Quality of Life (QOL), asthma symptoms and performed spirometry. Results: Prevalence of recent wheeze was 20.5% in Year 7 and 26.6% in Year 10 students (p <.02). The higher prevalence of wheeze in year 10 compared to Year 7 students tended to be greater among girls (6.4%) than boys (5.6%). Of students who reported wheezing within the last year, self- reported school absenteeism was 9.2 days with 10% having an asthma attack at school. QOL impairment due to asthma was mild (mean 5.5, where 1 = severe and 7= no impairment), and females reported more limitation (5.3) than males (5.7, p =.001). Only 5% had severe impairment due to asthma. Inhaled corticosteroids were used by 27% (n=76). Conclusions: Asthma is common in high school students in rural NSW, with older girls reporting more asthma. Females also experienced more impairment of QOL. The frequent asthma attacks at school underscore the need for effective asthma educational programs for this population.

1999 Henry R, Gibson P, Coughlan J, 'Treatment of reflux does not consistently improve asthma', Respirology, 4 (1999)

Asthma and gastroesophageal reflux (GOR) commonly coexist. The Australian Asthma Management Plan advises that treatment of GOR in patients with asthma and reflux may improve asthm... [more]

Asthma and gastroesophageal reflux (GOR) commonly coexist. The Australian Asthma Management Plan advises that treatment of GOR in patients with asthma and reflux may improve asthma. We conducted a systematic review to establish whether high quality literature supports the recommendation. Methods: Relevant articles were identified by a search of the Cochrane Airways Group clinical trials database. Two reviewers independently assessed articles for inclusion, methodological quality, study characteristics, interventions and outcomes. RCT's reporting the effects of GOR treatment on asthma were included. Results: From 18 potentially relevant RCT's, 9 were included. Agreement between assessors was 100%. Interventions were proton pump inhibitors (n=3), H2 antagonists (n=5), surgery (n=1) and conservative management (n=1). Treatment-time ranged from 1 week to 6 months. Although 6/9 trials reported that treatment improved at least 1 asthma outcome, these outcomes differed between trials. Overall, anti-reflux treatment did not consistently benefit FEV1, peak expiratory flow rate, asthma symptoms, nocturnal asthma symptoms or asthma medications in unselected asthmatic subjects. Significant improvement in wheeze was reported in 2 studies. One study included only subjects with asthma that was triggered by GOR, however treatment was too brief (1 week) to observe an effect. Conclusion: The published literature does not consistently support the treatment of GOR as a means to control asthma. Trials in asthma proven to be triggered by GOR are needed.

1999 Gibson PG, 'Asthma in general practice: action plans or planned actions', MEDICAL JOURNAL OF AUSTRALIA, 171 67-67 (1999)
Citations Scopus - 5Web of Science - 3
1999 Gibson PG, 'Airway hyperresponsiveness in asthma', THORAX, 54 656-657 (1999)
Citations Web of Science - 2
1999 Gibson PG, Brusasco V, Crimi E, Pellegrino R, 'Airway hyperresponsiveness in asthma (multiple letters) [4]', Thorax, 54 656-657 (1999)
Citations Scopus - 2
1999 Gibson PG, Wilson AJ, Wlodarczyk JH, Fakes K, Hensley MJ, 'Different patterns of airway inflammation during asthma exacerbation: a controlled dose reduction study.', JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 103 S61-S61 (1999)
Co-authors Amanda Wilson, Michael Hensley
1999 Gibson PG, Coughlan J, Abramson M, 'Self-management education for adults with asthma improves health outcomes', WESTERN JOURNAL OF MEDICINE, 170 266-266 (1999)
Citations Scopus - 12Web of Science - 5
1999 Fitzgerald DA, Wood LG, Cooper DM, Gibson PG, Garg ML, 'Isoprostanes and antioxidant defences in cystic fibrosis', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 159 A682-A682 (1999)
Co-authors Manohar Garg, Lisa Wood
1999 Chalmers A, Hensley MJ, Gibson P, Toneguzzi R, Lewis P, Ray C, 'Indoor air quality and the respiratory health of children living in Newcastle, Australia.', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 159 A774-A774 (1999)
Co-authors Michael Hensley
1999 Wark P, Simpson J, Fakes K, Burgess H, Timmins N, Hensley M, Gibson PG, 'Airway inflammation in allergic bronchopulmonary aspergillosis', Respirology, 4 (1999)

Allergic bronchopulmonary aspergillosis (ABPA) is a serious complication of asthma. In uncomplicated asthma airway inflammation(ai) is characterised by sputum eosinophilia without... [more]

Allergic bronchopulmonary aspergillosis (ABPA) is a serious complication of asthma. In uncomplicated asthma airway inflammation(ai) is characterised by sputum eosinophilia without an increase in the total cell count (TCC). In bronchiectasis the intensity of ai increased and there is a neutrophil infiltrate. Airway inflammation in ABPA is not well defined. This study tested the hypothesis that ai in ABPA would be of increased intensity with a mixed eosinophil/neutrophil pattern. Methods: In subjects with asthma, ABPA was assessed by 5 criteria; 1. positive allergy skin test to Aspergillus Fumigatus (Af); 2. raised specific serum IgE to Af; 3. positive precipitating antibodies to Af; 4. total IgE > 10001U/ml and 5. bronchiectasis (CT scan). Subjects were classified as definite ABPA (n=13) with criteria 1, 2, 3 and either 4 or 5; or as probable ABPA (n=18) with 1 and 2 and either 3, 4 or 5 (n=13). These groups were combined for analysis. Af sensitised subjects (n=19 with positive skin testing alone), were compared to a matched group with asthma (negative to Af on skin test) (n=15) and healthy controls (n=8). Spirometry, saline challenge and sputum induction were performed, with results reported as medians and interquartile ranges. Results: Patients with ABPA had an increased TCC (4.6, 0.9-29.6) compared to: Af sensitised (3.6, 1.4-7.4), asthma (1.5, 0.8-3.2), and controls (1.35, 1.3-1.4) (p<0.05). Those with ABPA had increased sputum eosinophils (3.8, 0.3-16.3), compared to: Af sensitised (1.4, 0.1-6), asthma (1.6, 0.01-3), and controls (0.3, 0.3-0.31 ) (p=0.001). Those with ABPA had increased levels of eosinophil cationic protein(ng/ml) (5471, 311-42485) compared to: Af sensitised (1432, 338-6902), asthma (244, 78-857), and controls (110, 99-121 ) (p<0.001). Neutrophil counts were similar in all groups. Myeloperoxidase was similar in ABPA (232, 66-454) and asthma (177, 57-318) (p=0.3) but greater than in healthy controls (76, 76-89) Conclusion: Airway inflammation in ABPA is of increased intensity compared to that of chronic asthma. Unlike bronchiectasis, the cellular infiltrate is predominantly eosinophilic. The eosinophils demonstrate increased activation.

1999 Simpson J, Wilson A, Fakes K, Burgess H, Saltos N, Gibson PG, 'Neutrophil activation in symptomatic asthma without eosinophilia', Respirology, 4 (1999)

In mild asthma there is typically an infiltrate with eosinophils, which improves with corticosteroid therapy. Asthma can persist despite high dose inhaled corticosteroid therapy (... [more]

In mild asthma there is typically an infiltrate with eosinophils, which improves with corticosteroid therapy. Asthma can persist despite high dose inhaled corticosteroid therapy (ICS). Aim: The aim of this study was to establish the characteristics of airway inflammation in asthma, which persists despite high dose inhaled corticosteroids. Method: Adults (n=73) with asthma and persistent symptoms who were taking =1000g ICS underwent hypertonic saline challenge and sputum induction. Sputum was dispersed using dithiothreitol and assayed for total cell count, cellular differential, supernatant eosinophil cationic protein (ECP ng/mL), myeloperoxidase (MPO ng/mL) and interleukin-8 (IL-8 ng/mL). Subjects were categorised into 4 groups based upon the presence or absence of airway hyperresponsiveness (AHR) and increased sputum eosinophils (E; being >5%). Results: Subjects with eosinophilic AHR (EAR n=16) had 22% E, compared to those with noneosinophilic AHR (NEAR, n=40) who had 1.5% E. Those with asthma in remission (normal AHR and E; n=14) had 1.2% E. Neutrophil % was similar in all 3 groups (p>0.05). ECP was highest in the EAR positive group (7572) compared with NEAR (2834) and remission (504; p = 0.001). MPO was elevated in NEAR (275) and EAR (253) compared with remission (189; p = 0.05). IL-8 levels were highest in NEAR (86.2) compared to EAR (36.5) and remission (12.9; p = 0.03). Conclusion: Asthma which remains symptomatic despite high dose ICS consists of 2 different inflammatory patterns. While some have typical eosinophil inflammation, the most common pattern is cellular (neutrophil and eosinophil) activation, with suppressed eosinophil counts. This may be mediated by IL-8 secretion. There is heterogeneity of airway inflammation in symptomatic asthma.

1999 Gibson PG, Coughlan J, Abramson M, 'Review: Self-management education for adults with asthma improves health outcomes: Commentary', Evidence-Based Medicine, 4 15 (1999)
1999 Gibson PG, Norzila MZ, Fakes K, Simpson J, Henry RL, 'Pattern of airway inflammation and its determinants in children with acute severe asthma', PEDIATRIC PULMONOLOGY, 28 261-270 (1999)
DOI 10.1002/(SICI)1099-0496(199910)28:4<261::AID-PPUL5>3.0.CO;2-I
Citations Scopus - 61Web of Science - 45
Co-authors Jodie Simpson
1998 Pizzichini E, Pizzichini MMM, Gibson P, Parameswaran K, Gleich GJ, Berman L, et al., 'Sputum eosinophilia predicts benefit from prednisone in smokers with chronic obstructive bronchitis', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 158 1511-1517 (1998)
Citations Web of Science - 160
1998 Cai Y, Carty K, Henry RL, Gibson PG, 'Persistence of sputum eosinophilia in children with controlled asthma when compared with healthy children', EUROPEAN RESPIRATORY JOURNAL, 11 848-853 (1998)
DOI 10.1183/09031936.98.11040848
Citations Scopus - 104Web of Science - 83
1998 Gibson PG, Woolley KL, Carty K, Murree-Allen K, Saltos N, 'Induced sputum eosinophil cationic protein (ECP) measurement in asthma and chronic obstructive airway disease (COAD)', CLINICAL AND EXPERIMENTAL ALLERGY, 28 1081-1088 (1998)
Citations Scopus - 39Web of Science - 38
1998 Gibson PG, Shah S, Mamoon HA, 'Peer-led asthma education for adolescents: Impact evaluation', JOURNAL OF ADOLESCENT HEALTH, 22 66-72 (1998)
DOI 10.1016/S1054-139X(97)00203-6
Citations Scopus - 45Web of Science - 39
1998 Gibson PG, 'How to measure airway inflammation: Induced sputum', Canadian Respiratory Journal, 5 (1998)

Induced sputum examination has emerged as an important investigative tool in airway diseases. Sputum can be easily induced by ultrasonic nebulization of Hypertonic saline. Inprove... [more]

Induced sputum examination has emerged as an important investigative tool in airway diseases. Sputum can be easily induced by ultrasonic nebulization of Hypertonic saline. Inprovements in sputum processing have established that sputum provides reproducible measurements of cell counts and fluid phase mediators. Adults and children with stable asthma demonstrate an infiltrate of eosinophils. With an exacerbation of asthma the eosinophil infiltrate increases and the cells become activated in response to cytokines including interleukin-5. A neutrophil infiltrate may accompany some exacerbations. Exacerbations resolve under the influence of corticosteroid therapy. Eosinophils undergo apoptosis and are removed by macrophages. Eosinophilic bronchitis is an important component in up to 20% of patients with chronic cough. Sputum examination promises to be an important technique to facilitate the understanding and management of asthma and cough in adults and children.

Citations Scopus - 7
1998 Gibson PG, 'Severe exacerbation of chronic obstructive airways disease: Health resource use in general practice and hospital', Journal of Quality in Clinical Practice, 18 125-133 (1998)

The objective of this study is to examine the treatment of exacerbations of chronic obstructive airways disease (COAD) in the hospital and in the community setting using a retrosp... [more]

The objective of this study is to examine the treatment of exacerbations of chronic obstructive airways disease (COAD) in the hospital and in the community setting using a retrospective study of patients admitted to a major teaching hospital combined with a general practice chart audit. The admission records for 248 admissions from 128 patients were reviewed. Most patients (70%) had visited their GP within 2 weeks of admission, antibiotics were prescribed for 30% of the exacerbations while 51% were treated with ingested corticosteroids. During hospitalization, features of infection were present in 64% (n = 159) of exacerbations and 79% (n = 196) received antibiotics. Patients were also treated with nebulized bronchodilators, oxygen and corticosteroids (82%). The median length of stay was 10 days (range 0-55). There was a high readmission rate (70%) at 1 year for exacerbation of COAD during the study period. Exacerbations of COAD frequently demonstrated the clinical features of infection. Treatment in general practice was less intensive than in hospital, and there is a need to reconcile these differences with studies of early therapy with antibiotics and corticosteroids. Although corticosteroids were used less often in general practice, the literature in this area is not conclusive and the evidence supporting guideline recommendations is not explicit. There are opportunities to examine the role of early therapy and early discharge programmes to minimize the cost burden from exacerbations of COAD.

Citations Scopus - 42
1998 Gibson PG, Coughlan J, Wilson AJ, Shekelle PG, 'Review: Limited asthma education reduces emergency department visits but does not improve patient outcomes', Evidence-Based Medicine, 3 121 (1998)
1998 Gibson PG, 'Loss-of-life cost for paediatric illness associated with parental smoking was estimated at U.S. $8.2 billion per year', Evidence-Based Medicine, 3 64 (1998)

Objective Tb calculate the costs of tobacco-related paediatric illness attributable to parental smoking in the United States. Design Cost-estimate study using techniques of litera... [more]

Objective Tb calculate the costs of tobacco-related paediatric illness attributable to parental smoking in the United States. Design Cost-estimate study using techniques of literature synthesis to generate the incidence and costs of tobacco-related paediatric illness. Data sources and selection English-language articles were identified by searching MEDLINE, HEALTH, BIOETHICSLINE, ECONLIT, and Social Sciences Citation Index from January 1980 to May 1996. Articles that included children in the age range of neonate to 18 years were used. For cost data, only articles referring to the United States were included. National databases and textbooks were used to obtain estimates of the prevalence of parental smoking and the incidence of the diseases in question. Main outcome and cost measures Best estimates of the relative risk for smoking-related diseases in children exposed to parental smoking were obtained, and the attributable risk fraction (the fraction of cases of disease that would not have occurred if no one in the population had been exposed) and direct medical expenditures were calculated. The cost of illness (based on costs for loss of life) was also calculated. Costs were adjusted to 1993 U.S. dollars. Main results Estimated annual excess cases of childhood illness and death caused by parental smoking in the United States were 5 400 000 and 6200, respectively, leading to direct medical costs of $4.6 billion and loss-of-life costs of $8.2 billion (Table). Conclusion Loss-of-life cost for paediatric illness associated with parental smoking was estimated at U.S. $8.2 billion per year.

1998 Henry RL, Gibson PG, Carty K, Cai Y, Francis JL, 'Airway inflammation after treatment with aerosolized deoxyribonuclease in cystic fibrosis', PEDIATRIC PULMONOLOGY, 26 97-100 (1998)
DOI 10.1002/(SICI)1099-0496(199808)26:2<97::AID-PPUL4>3.0.CO;2-E
Citations Scopus - 18Web of Science - 13
1998 Gibson PG, Wlodarczyk J, Hensley MJ, Henry RL, Cripps AW, Clancy RL, Gleeson M, 'Epidemiological association of airway inflammation with asthma symptoms and airway hyperresponsiveness in childhood', American Journal of Respiratory and Critical Care Medicine., 158 36-41 (1998) [C1]
Citations Scopus - 151Web of Science - 130
Co-authors Maree Gleeson, Michael Hensley
1998 Gibson PG, Zlatic K, Scott JL, Sewell W, Woolley K, Saltos N, 'Chronic cough resembles asthma with IL-5 and granulocyte-macrophage colony-stimulating factor gene expression in bronchoalveolar cells', Journal of Allergy and Clinical Immunology, 101 320-326 (1998) [C1]
Citations Scopus - 81Web of Science - 71
1998 Hensley MJ, Gibson PG, 'Promoting evidence-based alternative medicine', Medical Journal of Australia, 169 573-574 (1998) [C1]
Citations Scopus - 15Web of Science - 13
Co-authors Michael Hensley
1998 Jones PD, Henry R, Gibson PG, Hankin RG, Carty K, 'Chemotherapy for malignancy induces a remission in asthma symptoms and airway inflammation but not airway hyperreponsivesness', Pediatric Pulmonology, 26 74-77 (1998) [C1]
Citations Scopus - 5Web of Science - 4
1997 Carney IK, Gibson PG, MurreeAllen K, Saltos N, Olson LG, Hensley MJ, 'A systematic evaluation of mechanisms in chronic cough', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 156 211-216 (1997)
Citations Scopus - 102Web of Science - 85
Co-authors Michael Hensley
1997 Thorne RF, Meldrum CJ, Harris SJ, Dorahy DJ, Shafren DR, Berndt MC, et al., 'CD36 forms covalently associated dimers and multimers in platelets and transfected COS-7 cells', BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 240 812-818 (1997)
DOI 10.1006/bbrc.1997.7755
Citations Scopus - 27Web of Science - 24
Co-authors Rick Thorne
1997 Gibson P, 'Chronic Cough in Adults', Current Therapeutics, 38 50-56 (1997)
1996 Gibson PG, 'Corticosteroids - Clinical applications: Exacerbations of asthma in adults', Australian Prescriber, 19 44-47 (1996)

Corticosteroids are essential to reverse the eosinophilic airway inflammation which causes symptomatic exacerbations of asthma. Much of the current variation in clinical practice ... [more]

Corticosteroids are essential to reverse the eosinophilic airway inflammation which causes symptomatic exacerbations of asthma. Much of the current variation in clinical practice is not justified by data from clinical trials. Oral prednisolone is as effective as intravenous therapy and very high doses of corticosteroid are no better than modest doses (30- 50 mg prednisolone). Corticosteroids should be given twice a day for optimum effect. Therapy does not need to be tapered, but can be ceased abruptly after 10 days in most patients who are also taking high-dose inhaled corticosteroids. There is an increasing role for inhaled corticosteroids in the management of mild exacerbations of asthma. The dose, route and duration of therapy need to be defined for each patient and written down as part of an action plan to enable early intervention in future exacerbations.

Citations Scopus - 7
1996 Twaddell SH, Gibson PG, Carty K, Woolley KL, Henry RL, 'Assessment of airway inflammation in children with acute asthma using induced sputum', EUROPEAN RESPIRATORY JOURNAL, 9 2104-2108 (1996)
DOI 10.1183/09031936.96.09102104
Citations Scopus - 78Web of Science - 62
1996 Gibson PG, Stuart JE, Wlodarczyk J, Olson LG, Hensley MJ, 'Nasal inflammation and chronic ear disease in Australian Aboriginal children', JOURNAL OF PAEDIATRICS AND CHILD HEALTH, 32 143-147 (1996)
DOI 10.1111/j.1440-1754.1996.tb00911.x
Citations Scopus - 17Web of Science - 15
Co-authors John Stuart, Michael Hensley
1996 Twaddell SH, Henry RL, Francis JL, Gibson PG, 'The prediction of hospital admission in children with acute asthma', JOURNAL OF PAEDIATRICS AND CHILD HEALTH, 32 532-535 (1996)
DOI 10.1111/j.1440-1754.1996.tb00968.x
Citations Scopus - 14Web of Science - 12
1996 Gleeson M, Clancy RL, Hensley MJ, Cripps AW, Henry RL, Wlodarczyk JH, Gibson PG, 'Development of bronchial hyperreactivity following transient absence of salivary IgA', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 153 1785-1789 (1996)
Citations Scopus - 18Web of Science - 13
Co-authors Maree Gleeson, Michael Hensley
1996 Woolley KL, Gibson PG, Carty K, Wilson AJ, Woolley MJ, 'Eosinophil apoptosis and the resolution of airway inflammation in asthma', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 154 237-243 (1996)
Citations Scopus - 221Web of Science - 190
Co-authors Amanda Wilson
1996 Gibson PG, 'The use of continuous quality improvement methods to implement practice guidelines in asthma', Journal of Quality in Clinical Practice, 16 87-102 (1996)

National asthma management guidelines have improved awareness of the rising morbidity and mortality from asthma but have not been widely implemented at a local level. This paper d... [more]

National asthma management guidelines have improved awareness of the rising morbidity and mortality from asthma but have not been widely implemented at a local level. This paper describes the use of continuous quality improvement techniques to facilitate the implementation of asthma management guidelines within a tertiary hospital setting. A baseline audit demonstrated satisfactory emergency assessment and treatment, but identified poor compliance with the patient education aspects of the asthma management plan. An evaluation of the literature demonstrated that programs combining asthma education and management were effective when directed towards adults with a recent severe asthma exacerbation. An asthma education and management service was developed to address these deficits. A repeat audit was conducted which identified improvements in asthma control and management skills for patients attending the education program, together with reductions in asthma re-admission rates for patients referred to the service. Ongoing quality assessments will target nonattenders to the service and the maintenance of asthma skills. An area Asthma Health Outcomes Council was formed to address the issues of asthma management throughout the area health service.

Citations Scopus - 27
Co-authors Amanda Wilson
1996 Cai Y, Carty K, Gibson P, Henry R, 'Comparison of sputum processing techniques in cystic fibrosis', PEDIATRIC PULMONOLOGY, 22 402-407 (1996)
Citations Scopus - 16Web of Science - 17
1995 Gibson PG, Nair BR, Davies C, Saunders NA, 'Development and implementation of an innovative intern training programme', Medical Education, 29 220-224 (1995)

The quality of medical education during internship is a cause for concern. This paper describes a structured educational programme for interns that was based around learning modul... [more]

The quality of medical education during internship is a cause for concern. This paper describes a structured educational programme for interns that was based around learning modules, clinical attachments and bedside teaching. The programme was incorporated into the term rotation of interns within an Area Health Service, and evaluated. Learning modules were timetabled by a Programme Coordinator and interns were reminded to attend. Clinical attachments were organized by the interns from a list of willing supervisors. Attendance at timetabled learning modules averaged 67%, which was greater than the 27% attendance at clinical attachments. Both sessions received high ratings for quality and clinical relevance. This structured education programme was based upon adult learning methods and was both feasible and well received by interns. Intern training programmes need to be programmed into the working week to ensure attendance, and modified following evaluation by interns. Such programmes should be considered by all hospitals to which interns are allocated.

Citations Scopus - 4
1995 Gibson PG, Mattoli S, Sears MR, Dolovigh J, Hargreave FE, 'Increased peak flow variability in children with asymptomatic hyperresponsiveness', European Respiratory Journal, 8 1731-1735 (1995)

The relevance of increased methacholine airway responsiveness detected in children with no current or past symptoms of asthma is not known. We wished for determine whether the pre... [more]

The relevance of increased methacholine airway responsiveness detected in children with no current or past symptoms of asthma is not known. We wished for determine whether the presence of airway hyperresponsiveness in asymptomatic children is also associated with abnormal variability of peak expiratory flow (PEF). In 12 asymptomatic children with methacholine hyperresponsiveness, we examined the diurnal variation of peak expiratory flow (PEF) and response to inhaled bronchodilator. Twelve asthmatic children with a comparable range of methacholine hyperresponsiveness, and 12 normal children without methacholine responsiveness, were used as positive and negative controls. The children were aged 11 (range 9-14) yrs. The mean diurnal variation of PEF in those children with asymptomatic hyperresponsiveness was increased at 9.3%, to a degree comparable to the symptomatic asthmatic children (10.7%), and greater than the normal children (5.7%). Methacholine stimulated airway constriction was associated with symptoms in subjects from each group, indicating that the children were capable of perceiving airway constriction. We conclude that asymptomatic children with methacholine airway hyperresponsiveness have other evidence of mild variable airflow obstruction with increased diurnal PEF variability, and can perceive airflow limitation. The lack of symptoms in the children with airway hyperresponsiveness could be due to an insufficient stimulus to cause symptomatic obstruction, or the absence of eosinophilic airway inflammation, which may be a requirement for the development of symptomatic airway hyperresponsiveness.

DOI 10.1183/09031936.95.08101731
Citations Scopus - 29
1995 Gibson PG, Hargreave FE, Girgis-Gabardo A, Morris M, Denburg JA, Dolovich J, 'Chronic cough with eosinophilic bronchitis: Examination for variable airflow obstruction and response to corticosteroid', Clinical and Experimental Allergy, 25 127-132 (1995)

The purpose of this study was to examine airway responsiveness, sputum cells and the effects of inhaled corticosteroid in the chronic cough syndrome associated with eosinophilic b... [more]

The purpose of this study was to examine airway responsiveness, sputum cells and the effects of inhaled corticosteroid in the chronic cough syndrome associated with eosinophilic bronchitis. We studied nine consecutive referrals with chronic cough, sputum with >10% eosinophils, normal spirometry, and normal methacholine airway responsiveness. Clinical assessment, sputum analysis, allergy skin tests and a methacholine inhalation test were performed at the first visit. Peak expiratory flow (PEF) was measured twice daily for 1 week followed by an adenosine monophosphate (AMP) inhalation test. Subjects were then treated with inhaled beclomethasone 0.4 mg twice daily for 7 days. Sputum analysis and measurement of methacholine responsiveness were then repeated. Excessive airway narrowing to methacholine was not present in any of the subjects. A methacholine plateau response was present in five subjects. Hyperresponsiveness to AMP was absent in six of the nine subjects, and PEF variability was not increased for eight subjects. Corticosteroid therapy led to a reduction in sputum eosinophil counts from 40.1 (SD 21 4)% to 4.0 (4.5)% but there was no significant change in metachromatic cell counts (0.8 SD 0.5% vs 0.6 SD 0.6%) or total cell counts. Methacholine responsiveness improved within the normal range in the three subjects in whom it could be determined. Chronic cough associated with eosinophilic airway inflammation can occur in the absence of variable airflow obstruction (asthma) and can improve after treatment with inhaled corticosteroid. This treatment can reduce the level of methacholine responsiveness within the normal range and reduces sputum eosinophils but not mast eels. These results suggest that the occurrence of variable airflow obstruction depends on the baseline level of methacholine responsiveness, the degree of eosinophilic infiltration and the degree to which methacholine responsiveness becomes heightened.

DOI 10.1111/j.1365-2222.1995.tb01017.x
Citations Scopus - 130
1995 GIBSON PG, WLODARCZYK J, HENSLEY MJ, MURREEALLEN K, OLSON LG, SALTOS N, 'USING QUALITY-CONTROL ANALYSIS OF PEAK EXPIRATORY FLOW RECORDINGS TO GUIDE THERAPY FOR ASTHMA', ANNALS OF INTERNAL MEDICINE, 123 488-& (1995)
Citations Scopus - 57Web of Science - 60
Co-authors Michael Hensley
1995 GIBSON PG, HENRY RL, VIMPANI GV, HALLIDAY J, 'ASTHMA KNOWLEDGE, ATTITUDES, AND QUALITY-OF-LIFE IN ADOLESCENTS', ARCHIVES OF DISEASE IN CHILDHOOD, 73 321-326 (1995)
Citations Scopus - 106Web of Science - 80
1995 GIBSON PG, WLODARCZYK JH, BORGAS T, 'DRUG-DELIVERY IN ASTHMA - A COMPARISON OF SPACERS WITH A JET NEBULIZER', AUSTRALIAN AND NEW ZEALAND JOURNAL OF MEDICINE, 25 324-329 (1995)
DOI 10.1111/j.1445-5994.1995.tb01897.x
Citations Scopus - 11Web of Science - 10
1995 GIBSON PG, TALBOT PI, TONEGUZZI RC, 'SELF-MANAGEMENT, AUTONOMY, AND QUALITY-OF-LIFE IN ASTHMA', CHEST, 107 1003-1008 (1995)
DOI 10.1378/chest.107.4.1003
Citations Scopus - 91Web of Science - 68
1995 Gibson PG, Talbot PI, Toneguzzi RC, 'Self-management, autonomy, and quality of life in asthma. Population Medicine Group 91C.', Chest, 107 1003-1008 (1995)
1994 Gibson PG, 'Computer-supported education reduced hospital admissions in asthma', Annals of Internal Medicine, 121 20-21 (1994)
1994 SHAH S, GIBSON PG, WACHINGER S, 'RECOGNITION AND CRISIS MANAGEMENT OF ASTHMA IN SCHOOLS', JOURNAL OF PAEDIATRICS AND CHILD HEALTH, 30 312-315 (1994)
DOI 10.1111/j.1440-1754.1994.tb00652.x
Citations Web of Science - 12
1994 HENRY RL, GIBSON PG, VIMPANI GV, HAZELL J, LEGGATT R, MOWBRAY C, et al., 'INTEGRATED HEALTH AND EDUCATION INPUT IN THE DEVELOPMENT OF EDUCATIONAL RESOURCES ABOUT ASTHMA FOR SCHOOLS', JOURNAL OF PAEDIATRICS AND CHILD HEALTH, 30 492-496 (1994)
DOI 10.1111/j.1440-1754.1994.tb00719.x
Citations Scopus - 8Web of Science - 8
1993 GIBSON PG, MURREEALLEN K, HOPKINS Y, BENNETTS K, 'DO FOOD-ADDITIVES INDUCE AIRWAYS INFLAMMATION IN ASTHMA', AMERICAN REVIEW OF RESPIRATORY DISEASE, 147 A559-A559 (1993)
1993 GIBSON PG, HENSLEY MJ, HOPKINS YJ, WLODARCZYK J, TONEGUZZI R, 'EPIDEMIC ASTHMA AFTER A THUNDERSTORM - CLINICAL AND CYTOLOGICAL FEATURES OF NEW ONSET ASTHMA', AMERICAN REVIEW OF RESPIRATORY DISEASE, 147 A560-A560 (1993)
Co-authors Michael Hensley
1993 Gibson PG, Allen CJ, Yang JP, Wong BJO, Dolovich J, Denburg J, Hargreave FE, 'Intraepithelial mast cells in allergic and nonallergic asthma: Assessment using bronchial brushings', American Review of Respiratory Disease, 148 80-86 (1993)

Mast cell mediators are known to contribute to the pathogenesis of asthma. There is some disagreement concerning the numbers of mast cells in asthmatic mucosa. In this study a sta... [more]

Mast cell mediators are known to contribute to the pathogenesis of asthma. There is some disagreement concerning the numbers of mast cells in asthmatic mucosa. In this study a standardized bronchial brush technique was developed and used to assess intraepithelial mast cells and other inflammatory cells in allergic and nonallergic asthmatic and nonasthmatic subjects. A total of 10 nonasthmatic (5 allergic) and 13 asthmatic (8 allergic) subjects with stable controlled asthma treated with ß-agonist only were assessed by history, spirometry, allergy prick tests, and methacholine airway responsiveness. During fiberoptic bronchoscopy, bronchoalveolar lavage (BAL) was performed from the middle lobe and standardized bronchial brushings were taken from the lingula and left lower lobe bronchi. Quantitative cell counts were performed blind to the clinical characteristics of the subjects. The average total cell recovery from the brushings was 1.04 (SEM 0.09) x 106 ml, with a cell viability of 64% (5.3%). Reproducible total cell and mast cell counts were obtained from brushings taken from two lobar bronchi (ICC 0.86). Mast cells were significantly elevated in asthmatic compared with nonasthmatic subjects (1.5 ± 0.34 versus 0.15 ± 0.06%). Allergic asthmatic subjects had the greatest numbers of mast cells (1.86 ± 0.48%); however, the numbers present in brushings from nonallergic asthmatic subjects were also increased (1.03 ± 0.45%). The mast cells had the staining characteristics of mucosal mast cells, with formalin-blockable metachromatic staining and positive staining for tryptase. Both asthmatic groups also had elevated BAL eosinophils, and neutrophils were elevated in nonallergic asthmatic subjects. We conclude that bronchial brushings are a useful technique for sampling intraepithelial mast cells and that there is an accumulation of mast cells within the airway epithelium in asthma that is independent of allergy. The microenvironment within the bronchial epithelium may favor mast cell accumulation and the acquisition of a particular mast cell phenotype, which in turn may contribute to persisting airway inflammation and hyperresponsiveness in asthma.

Citations Scopus - 101
1993 GIBSON P, 'ASTHMA GUIDELINES AND EVIDENCE-BASED MEDICINE', LANCET, 342 1305-1305 (1993)
DOI 10.1016/0140-6736(93)92399-E
Citations Scopus - 17Web of Science - 16
1993 GIBSON PG, TALBOT PI, HANCOCK J, HENSLEY MJ, 'A PROSPECTIVE AUDIT OF ASTHMA MANAGEMENT FOLLOWING EMERGENCY ASTHMA-TREATMENT AT A TEACHING HOSPITAL', MEDICAL JOURNAL OF AUSTRALIA, 158 775-778 (1993)
Citations Scopus - 41Web of Science - 45
Co-authors Michael Hensley
1993 Blackie JD, Gibson P, Murree-Allen K, Saul WP, 'Acute myopathy in status asthmaticus.', Clinical and experimental neurology, 30 72-81 (1993)

An acute myopathy complicating life-threatening asthma has been reported with increasing frequency. We present a further 3 patients with this complication. Each patient had nerve ... [more]

An acute myopathy complicating life-threatening asthma has been reported with increasing frequency. We present a further 3 patients with this complication. Each patient had nerve conduction studies, electromyography and muscle biopsy performed. The records of a cohort of 12 patients, ventilated in an intensive care unit over a 16 month period, were reviewed. Eleven out of the 12 patients developed an elevated creatine kinase level (median 1311 U/L, range 185-9973 U/L) and 4 developed symptomatic weakness. The myopathy of status asthmaticus is not a homogeneous clinicopathological entity. Although myopathy is the predominant feature, there is a neuropathic component in some patients. Full recovery is usual. The combination of corticosteroids and neuromuscular blocking agents has been proposed as the possible cause of the complication.

Citations Scopus - 9
1993 GIBSON P, HENRY D, FRANCIS L, CRUICKSHANK D, DUPEN F, HIGGINBOTHAM N, et al., 'ASSOCIATION BETWEEN AVAILABILITY OF NONPRESCRIPTION BETA(2) AGONIST INHALERS AND UNDERTREATMENT OF ASTHMA', BRITISH MEDICAL JOURNAL, 306 1514-1518 (1993)
Citations Scopus - 30Web of Science - 35
1992 HENRY DA, GIBSON P, CRUICKSHANK D, FRANCIS L, DUPEN F, HIGGINBOTHAM N, HENRY RL, 'NONPRESCRIPTION USE OF BRONCHODILATOR AEROSOLS', MEDICAL JOURNAL OF AUSTRALIA, 156 68-68 (1992)
Citations Scopus - 3Web of Science - 7
1990 HARGREAVE FE, GIBSON PG, RAMSDALE EH, 'AIRWAY HYPERRESPONSIVENESS, AIRWAY INFLAMMATION, AND ASTHMA', IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA, 10 439-448 (1990)
Citations Web of Science - 7
Show 466 more journal articles

Review (12 outputs)

Year Citation Altmetrics Link
2016 Grainge CL, Maltby S, Gibson PG, Wark PA, McDonald VM, 'Targeted therapeutics for severe refractory asthma: monoclonal antibodies.', Expert Rev Clin Pharmacol (2016)
DOI 10.1586/17512433.2016.1172208
Co-authors Vanessa Mcdonald, Peter Wark, Christopher Grainge, Steven Maltby
2016 Wark PA, Hew M, Maltby S, McDonald VM, Gibson PG, 'Diagnosis and investigation in the severe asthma clinic.', Expert Rev Respir Med (2016)
DOI 10.1586/17476348.2016.1165096
Co-authors Peter Wark, Steven Maltby, Vanessa Mcdonald
2013 Gibson PG, 'Asthma and Obesity, the Twin Epidemics (2013) [D2]
2004 Powell HG, Gibson PG, 'High Dose versus low dose inhaled corticosteroid as initial starting dose for asthma in adults and children', ACP Journal Club (2004) [D2]
2004 Wark PA, Gibson PG, Wilson AJ, 'Azoles for Allergic Bronchopulmonary Aspergillosis Associated With Asthma', Cochrane Database of Systematic Reviews (2004) [D1]
DOI 10.1002/14651858.CD001108
Citations Scopus - 1
Co-authors Amanda Wilson, Peter Wark
2004 Taramarcaz P, Gibson PG, 'Intranasal Corticosteroids for Asthma control in People with Coexisting Asthma and Rhinitis', Cochrane Database of Systematic Reviews (2004) [D1]
2004 Shah S, Wilson AJ, Gibson PG, Coughlan J, 'Long Acting Beta-Agonists Versus Theophylline for Maintenance Treatment of Asthma', Cochrane Database of Systematic Reviews (2004) [D1]
DOI 10.1002/14651858.CD001281
Citations Scopus - 13
Co-authors Amanda Wilson
2004 Gibson PG, Powell HG, Coughlan J, Wilson AJ, Abramson M, Haywood P, et al., 'Self-Management Education and Regular Practitioner Review for Adults With Asthma', Cochrane Database of Systematic Reviews (2004) [D1]
Citations Scopus - 68
Co-authors Amanda Wilson, Michael Hensley
2004 Powell HG, Gibson PG, 'Options for Self-Management Education for Adults with Asthma', Cochrane Database of Systematic Reviews (2004) [D1]
Citations Scopus - 17
2004 Gibson PG, Henry RL, Coughlan J, 'Gastro-Oesophageal Reflux Treatment for Asthma in Adults and Children', Cochrane Database of Systematic Reviews (2004) [D1]
Citations Scopus - 22
2003 Lacasse Y, Brosseau L, Milne S, Gibson PG, 'Respiratory rehabilitation improves health-related quality of life in chronic obstructive pulmonary disease', A C P Journal Club (2003) [D1]
2003 Wood LG, Gibson PG, Garg ML, 'Biomarkers of lipid peroxidation, airway inflammation and asthma', The European Respiratory Journal (2003) [D2]
Citations Scopus - 166Web of Science - 149
Co-authors Manohar Garg, Lisa Wood
Show 9 more reviews

Conference (314 outputs)

Year Citation Altmetrics Link
2016 Negewo N, Mcdonald V, Baines K, Wark P, Simpson J, Jones P, Gibson P, 'BLOOD EOSINOPHILS AS A SURROGATE MARKER FOR SPUTUM EOSINOPHILIA IN STABLE COPD', RESPIROLOGY (2016)
Co-authors Peter Wark, Vanessa Mcdonald, Jodie Simpson
2016 Leong L, Rogers G, Gibson P, Yang I, Reynolds P, Hodge S, et al., 'THE LUNG MICROBIOTA IN STABLE ADULT ASTHMA DIFFERS ACCORDING TO INFLAMMATORY PHENOTYPE', RESPIROLOGY (2016)
Co-authors Jodie Simpson
2016 Gibson P, Reddel H, Jenkins C, Marks G, Upham J, Gillman A, et al., 'EFFECTIVENESS AND RESPONSE PREDICTORS OF OMALIZUMAB IN A SEVERE ALLERGIC ASTHMA POPULATION WITH A HIGH PREVALENCE OF COMORBIDITIES: THE AUSTRALIAN XOLAIR REGISTRY', RESPIROLOGY (2016)
Co-authors Peter Wark, Vanessa Mcdonald
2016 Simpson J, Lochrin A, Wood L, Gibson P, 'SPUTUM COLOUR AS A MARKER OF NEUTROPHILIC BRONCHITIS IN ADULTS WITH ASTHMA', RESPIROLOGY (2016)
Co-authors Jodie Simpson
2016 Simpson J, Powell H, Yang I, Upham J, Reynolds P, Hodge S, et al., 'SPUTUM INFLAMMATORY PHENOTYPES IN SYMPTOMATIC ASTHMA AROUND AUSTRALIA', RESPIROLOGY (2016)
Co-authors Jodie Simpson
2016 Harvey E, Gibson P, Bardin P, Peters M, Reynolds P, Upham J, et al., 'CHARACTERISATION OF SEVERE ASTHMA PHENOTYPES VIA A SEVERE ASTHMA REGISTRY: THE SEVERE ASTHMA WEB-BASED DATABASE', RESPIROLOGY (2016)
Co-authors Peter Wark, Vanessa Mcdonald
2016 Harvey E, Gibson P, Bardin P, Peters M, Reynolds P, Upham J, et al., 'SEVERE ASTHMA IS ASSOCIATED WITH WORK PRODUCTIVITY LOSS, ACTIVITY IMPAIRMENT AND REDUCED QUALITY OF LIFE', RESPIROLOGY (2016)
Co-authors Vanessa Mcdonald, Peter Wark
2016 Negewo N, Gibson P, Wood L, Baines K, McDonald V, 'DOES WEIGHT LOSS COUPLED WITH RESISTANCE TRAINING IN OBESE COPD PATIENTS IMPROVE OTHER INTERRELATED COMORBIDITIES?', RESPIROLOGY (2016)
Co-authors Vanessa Mcdonald
2016 Samuel S, Wood-Baker R, Gibson P, Yang I, Hutchinson A, Sajkov D, Mcdonald V, 'COPD ASSESSMENT TEST (CAT) AS A PREDICTOR FOR MORTALITY AND READMISSION FOLLOWING HOSPITALISATION FOR ACUTE EXACERBATION OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)', RESPIROLOGY (2016)
Co-authors Vanessa Mcdonald
2016 Berthon B, Gibson P, Wood L, Macdonald-Wicks L, Baines K, 'A NOVEL GENE EXPRESSION SIGNATURE IN SPUTUM PREDICTS ORAL CORTICOSTEROID RESPONSE IN ASTHMA', RESPIROLOGY (2016)
Co-authors Lesley Wicks
2015 Upham J, Chen A, Carroll M, Petsky H, Pizzutto S, Yerkovich S, et al., 'IMMUNE RESPONSES TO NONTYPEABLE HAEMOPHILUS INFLUENZAE IN PROTRACTED BACTERIAL BRONCHITIS', RESPIROLOGY (2015) [E3]
Co-authors Katherine Baines, Jodie Simpson
2015 Baines K, Wright T, Simpson J, Mcdonald V, Wood L, Gibson P, 'EXCESSIVE NEUTROPHIL EXTRACELLULAR TRAPS ARE ASSOCIATED WITH INFLAMMATION IN CHRONIC AIRWAY DISEASE', RESPIROLOGY (2015) [E3]
Co-authors Vanessa Mcdonald, Lisa Wood, Katherine Baines, Jodie Simpson
2015 Simpson J, Yang IA, Upham JW, Reynolds PN, Hodge S, James AL, et al., 'SPUTUM AND SERUM PERIOSTIN LEVELS ARE ASSOCIATED WITH, BUT DO NOT PREDICT SPUTUM EOSINOPHIL PROPORTION IN SEVERE ASTHMA', RESPIROLOGY (2015) [E3]
Co-authors Jodie Simpson
2015 Erriah M, Gao P, Baines K, Gibson P, Simpson J, 'SPUTUM GALECTIN-3 EXPRESSION IS ASSOCIATED WITH EOSINOPHILS IN COPD', RESPIROLOGY (2015) [E3]
Co-authors Katherine Baines, Jodie Simpson
2015 Murphy V, Powell H, Gibson P, 'EXACERBATIONS FOLLOWING STEP DOWN AND STEP UP INHALED CORTICOSTEROID THERAPY IN THE MANAGING ASTHMA IN PREGNANCY (MAP) STUDY', RESPIROLOGY (2015) [E3]
Co-authors Vanessa Murphy
2015 Wark P, Mcdonald V, Gibson P, 'A TREATMENT ALGORITHM ADJUSTING ORAL CORTICOSTEROID USING BLOOD EOSINOPHILS REDUCES EXACERBATIONS AND IMPROVES ASTHMA CONTROL, IN DIFFICULT ASTHMATICS', RESPIROLOGY (2015) [E3]
Co-authors Vanessa Mcdonald, Peter Wark
2015 Steven A, Gibson P, Wark P, Mcdonald V, 'THE USE OF AZOLES IN AIRWAYS DISEASE: A RETROSPECTIVE AUDIT', RESPIROLOGY (2015) [E3]
Co-authors Vanessa Mcdonald, Peter Wark
2015 McDonald V, Wark P, Baines K, Gibson P, 'A multidimensional assessment of severe asthma', American Journal of Respiratory and Critical Care Medicine (2015) [E3]
Co-authors Peter Wark, Vanessa Mcdonald, Katherine Baines
2015 Tang F, Gibson P, Foxley G, Burgess J, Baines K, Oliver B, 'Neutrophils from people with uncontrolled asthma have a deficient CXCL8 response to bacteria but not to viruses', Am J Resp Crit Care Med (2015) [E3]
Co-authors Katherine Baines
2015 Baines K, Wright T, Simpson J, McDonald V, Wood L, Gibson P, 'Accumulation of neutrophil extracellular traps is associated with inflammation in neutrophilic asthma and COPD', Am J Resp Crit Care Med (2015) [E3]
Co-authors Jodie Simpson, Vanessa Mcdonald, Katherine Baines, Lisa Wood
2015 McDonald V, Wark P, Baines K, Gibson P, 'The multidimensional components of severe asthma', Respirology (2015) [E3]
Co-authors Vanessa Mcdonald, Peter Wark, Katherine Baines
2015 Tang F, Gibson P, Foxley G, Burgess J, Baines K, Oliver B, 'Deficient CXCL8 response to bacteria but not to viruses in neutrophils from people with uncontrolled asthma', Respirology (2015) [E3]
Co-authors Katherine Baines
2015 Hew M, Gillman A, Wark P, Bowden J, Sutherland M, Gibson P, 'OMALIZUMAB TREATMENT IMPROVES CLINICAL OUTCOME IN SEVERE ALLERGIC ASTHMA PATIENTS ABOVE THE DOSING RANGE', INTERNAL MEDICINE JOURNAL (2015) [E3]
Co-authors Peter Wark
2014 Upham JW, Carroll M, Gibson P, Yang IA, Simpson J, 'Anti-Viral Innate Immunity Varies Across Different Asthma Inflammatory Phenotypes', JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2014) [E3]
Co-authors Jodie Simpson
2014 Vertigan AE, Gibson PG, Bone SL, 'Laryngeal Hypersensitivity in Chronic Refractory Cough and Paradoxical Vocal Fold Movement', LUNG (2014) [E3]
2014 Lewis A, Pretto J, Gibson P, 'UTILITY OF IMPULSE OSCILLOMETRY IN DETECTING UPPER AIRWAY DYSFUNCTION DURING HYPERTONIC SALINE CHALLENGE', RESPIROLOGY (2014) [E3]
DOI 10.1111/resp.12261
2014 Eckert B, Simpson J, Powell H, Pretto J, Upham J, Gibson P, 'EXHALED NITRIC OXIDE MEASUREMENT: INTER-INSTRUMENT VARIABILITY AND IMPLICATIONS ON TEST INTERPRETATION', RESPIROLOGY (2014) [E3]
DOI 10.1111/resp.12262_16
Co-authors Jodie Simpson
2014 Periyalil H, Scott H, Jensen M, Wood L, Gibson P, 'MACROPHAGE ACTIVATION IS A DETERMINANT OF DEVELOPMENTAL EFFECTS OF IMMUNOMETABOLISM IN OBESE ASTHMA', RESPIROLOGY (2014) [E3]
DOI 10.1111/resp.12263_7
Co-authors Lisa Wood, Hayley Scott
2014 Berthon B, Macdonald-Wicks L, Gibson P, Wood L, 'SHORT TERM ORAL CORTICOSTEROID THERAPY DOES NOT INCREASE APPETITE, DIETARY INTAKE, BODY WEIGHT AND BODY COMPOSITION IN ADULTS WITH ASTHMA - A RANDOMIZED-CONTROLLED TRIAL', RESPIROLOGY (2014) [E3]
Co-authors Lesley Wicks, Lisa Wood
2014 Wright T, Gibson P, Simpson J, Mcdonald V, Wood L, Baines K, 'ALARMINS IN ASTHMA AND COPD: RELATIONSHIPS TO INFLAMMATORY PHENOTYPES AND DISEASE SEVERITY', RESPIROLOGY (2014) [E3]
Co-authors Jodie Simpson, Vanessa Mcdonald, Katherine Baines, Lisa Wood
2014 Baines K, Simpson J, Wood L, Scott R, Fibbens N, Powell H, et al., 'SPUTUM GENE EXPRESSION OF SIX MARKERS IDENTIFIES ASTHMA INFLAMMATORY PHENOTYPE AND CORTICOSTEROID RESPONSE', RESPIROLOGY (2014) [E3]
Co-authors Lisa Wood, Jodie Simpson, Katherine Baines, Rodney Scott
2014 Wood L, Shivappa N, Berthon B, Gibson P, Hebert J, 'DIETARY INFLAMMATORY INDEX IS RELATED TO ASTHMA RISK, LUNG FUNCTION AND SYSTEMIC INFLAMMATION IN ASTHMA', RESPIROLOGY (2014) [E3]
Citations Web of Science - 1
Co-authors Lisa Wood
2014 Mcdonald V, Gibson P, Scott H, Baines P, Hensley M, Pretto J, Wood L, 'SHOULD WE TREAT OBESITY IN COPD? THE EFFECTS OF WEIGHT LOSS AND RESISTANCE TRAINING IN OBESE COPD', RESPIROLOGY (2014) [E3]
Co-authors Vanessa Mcdonald, Hayley Scott, Michael Hensley, Lisa Wood
2014 Baines K, Upham J, Yerkovich S, Chang A, Marchant J, Carroll M, et al., 'INTERLEUKIN-1B IS RELATED TO CLINICAL OUTCOMES IN PROTRACTED BACTERIAL BRONCHITIS', RESPIROLOGY (2014) [E3]
Co-authors Katherine Baines, Jodie Simpson
2014 Eckert B, Simpson J, Powell H, Pretto J, Upham J, Gibson P, 'EXHALED NITRIC OXIDE MEASUREMENT: INTER-INSTRUMENT VARIABILITY AND IMPLICATIONS ON TESTS INTERPRETATION', RESPIROLOGY (2014) [E3]
Co-authors Jodie Simpson
2014 Simpson J, Gao P, Baines K, Yang I, Reynolds P, Hodge S, et al., 'GALECTIN 3 AND GALECTIN 3 BINDING PROTEIN IN ASTHMA INFLAMMATORY SUBTYPES', RESPIROLOGY (2014) [E3]
Co-authors Katherine Baines, Jodie Simpson
2014 Simpson J, Carroll M, Gibson P, Yang I, Reynolds P, Hodge S, et al., 'REDUCED ANTI-VIRAL INNATE IMMUNITY IN PATIENTS WITH SEVERE ASTHMA IS ASSOCIATED WITH NEUTROPHILIC INFLAMMATION AND HIGH DOSE INHALED STEROIDS', RESPIROLOGY (2014) [E3]
Co-authors Jodie Simpson
2014 Murphy V, Powell H, Gibson P, 'THE ROLE OF MATERNAL OBESITY IN SUSCEPTIBILITY TO RESPIRATORY VIRAL INFECTION AND EXACERBATION RATE IN PREGNANT WOMEN WITH ASTHMA', RESPIROLOGY (2014)
Co-authors Vanessa Murphy
2014 Guo M, Gibson P, Thien F, Peters M, Sutherland M, Upham J, et al., 'SEVERE REFRACTORY ALLERGIC ASTHMA IN AUSTRALIA: THE AUSTRALIAN XOLAIR REGISTRY (AXR)', RESPIROLOGY (2014)
2014 Hodge G, Upham J, Chang A, Gibson P, Pizzutto S, Petsky H, Hodge S, 'INCREASED PERIPHERAL BLOOD PRO-INFLAMMATORY/CYTOTOXIC T AND NKT-LIKE CELLS IN INDIGENOUS CHILDREN WITH BRONCHIECTASIS', RESPIROLOGY (2014)
2014 Sutherland M, Gibson P, Thien F, Peters M, Upham J, Reddel H, et al., 'SEVERE REFRACTORY ALLERGIC ASTHMA IN AUSTRALIA: THE AUSTRALIAN XOLAIR REGISTRY (AXR)', INTERNAL MEDICINE JOURNAL (2014) [E3]
2013 Scott HA, Gibson PG, Garg ML, Smart J, Wood LG, 'Female Reproductive Stage Drives The Association Between Obesity And Neutrophilic Airway Inflammation In Adults With Asthma', American Journal of Respiratory and Critical Care Medicine (2013) [E3]
Co-authors Hayley Scott, Lisa Wood, Manohar Garg
2013 Scott HA, Gibson PG, Garg ML, Smart JM, Wood LG, 'The Association Between Obesity and Asthma is Driven By Female Reproductive Stage', Australasian Medical Journal (2013) [E3]
Co-authors Hayley Scott, Lisa Wood, Manohar Garg
2013 Jayasinha R, Brown N, Towns SM, Gibson PG, Jaffe A, Chang AB, 'Preventing tobacco smoking in disadvantaged and indigenous young people', Respirology (2013) [E3]
2013 Berthon B, MacDonald-Wicks L, Gibson P, Wood L, 'Changes in body composition are associated with corticosteroid use in adult asthma', EUROPEAN RESPIRATORY JOURNAL (2013)
Co-authors Lesley Wicks, Lisa Wood
2013 Scott HA, Gibson PG, Garg ML, Smart J, Wood LG, 'REPRODUCTIVE STAGE DRIVES LINK BETWEEN OBESITY AND NEUTROPHILIC AIRWAY INFLAMMATION IN FEMALES WITH ASTHMA', RESPIROLOGY (2013) [E3]
Co-authors Hayley Scott, Manohar Garg, Lisa Wood
2013 Fu JJ, Mcdonald VM, Simpson JL, Higgins I, Mao B, Gibson PG, 'VALIDATION OF THE NEW GOLD COMBINED ASSESSMENT IN AN AUSTRALIAN COPD COHORT', RESPIROLOGY (2013) [E3]
Co-authors Vanessa Mcdonald, Isabel Higgins, Jodie Simpson
2013 Mattes J, Murphy V, Powell H, Gibson P, 'THE EFFECT OF BETTER ASTHMA CONTROL IN PREGNANCY ON WHEEZY ILLNESSES IN INFANCY', RESPIROLOGY (2013) [E3]
Citations Web of Science - 2
Co-authors Vanessa Murphy, Joerg Mattes
2013 Forbes RL, Gibson PG, Murphy VE, Wark PA, 'H1N1PDM09 ALTERS MATERNAL IMMUNITY DURING PREGNANCY', RESPIROLOGY (2013) [E3]
Co-authors Peter Wark, Vanessa Murphy
2013 Gunawardhana LP, Baines KJ, Mattes J, Murphy VE, Simpson JL, Gibson PG, 'EPIGENETIC ALTERATIONS IN INFANTS ASSOCIATED WITH MATERNAL ASTHMA DURING PREGNANCY', RESPIROLOGY (2013) [E3]
Co-authors Katherine Baines, Jodie Simpson, Vanessa Murphy, Joerg Mattes
2013 Powell H, Garside CG, Simpson JL, Yang IA, Reynolds PN, Hodge SJ, et al., 'CHARACTERISTICS OF UNCONTROLLED ASTHMA IN AUSTRALIA', RESPIROLOGY (2013) [E3]
Co-authors Jodie Simpson
2013 Simpson JL, Yang IA, Reynolds PN, Hodge SJ, James AL, Upham J, et al., 'ALTERNATIVES TO INDUCED SPUTUM FOR IDENTIFYING PATIENTS WITH EOSINOPHILIC ASTHMA', RESPIROLOGY (2013) [E3]
Co-authors Jodie Simpson
2013 Simpson JL, Baines KJ, Ryan NM, Gibson PG, 'NEUTROPHILIC ASTHMA IS CHARACTERIZED BY INCREASED GERD AND RHINOSINUSITIS WITH SLEEP DISTURBANCE', RESPIROLOGY (2013) [E3]
Co-authors Nicole Ryan, Jodie Simpson, Katherine Baines
2013 Berthon BS, Macdonald-Wicks LK, Gibson PG, Wood LG, 'PARTIAL OR POOR ASTHMA CONTROL IS RELATED TO ANXIETY AND DEPRESSION SCORES', RESPIROLOGY (2013) [E3]
Co-authors Lesley Wicks, Lisa Wood
2013 Baines KJ, Simpson JL, Mcdonald VM, Hsu AC, Gibson PG, 'DIFFERENTIAL AIRWAY GENE EXPRESSION IN COPD', RESPIROLOGY (2013) [E3]
Co-authors Jodie Simpson, Vanessa Mcdonald, Katherine Baines, Alan Hsu
2013 Mcdonald VM, Wood LG, Baines P, Higgins I, Gibson PG, 'OBESITY IN COPD PROTECTIVE FOR OSTEOPOROSIS?', RESPIROLOGY (2013) [E3]
Co-authors Lisa Wood, Isabel Higgins, Vanessa Mcdonald
2013 Wang G, Baines KJ, Fu JJ, Gibson PG, 'MAST CELL-BASED PHENOTYPES OF ASTHMA IN INDUCED SPUTUM SAMPLES', RESPIROLOGY (2013) [E3]
Co-authors Katherine Baines
2013 Horvat JC, Essilfie A-T, Kim RY, Mayall JR, Starkey MR, Beckett EL, et al., 'MACROLIDES SUPPRESS KEY FEATURES OF EXPERIMENTAL STEROID-SENSITIVE AND STEROID-RESISTANT ASTHMA', RESPIROLOGY (2013) [E3]
Co-authors Paul Foster, Jodie Simpson, Jay Horvat, Philip Hansbro, Malcolm Starkey
2012 Scott HA, Gibson PG, Garg ML, Smart JM, Wood LG, 'Female reproductive stage drives the association between obesity and neutrophilic airway inflammation in adults with asthma', Abstracts. American Thoracic Society 2012 International Conference (2012) [E3]
Co-authors Hayley Scott, Lisa Wood, Manohar Garg
2012 Jensen ME, Gibson PG, Collins CE, Wood LG, 'Distribution of lean and fat mass differentially affect lung function in children', Abstracts. American Thoracic Society 2012 International Conference (2012) [E3]
Co-authors Clare Collins, Lisa Wood
2012 Jensen ME, Gibson PG, Collins CE, Wood LG, 'Systemic inflammation and clinical asthma outcomes in obese and non-obese children: A cross-sectional study', Abstracts. American Thoracic Society 2012 International Conference (2012) [E3]
Co-authors Clare Collins, Lisa Wood
2012 Fu J, McDonald VM, Gibson PG, Simpson JL, 'Systemic inflammation in older adults with asthma-COPD overlap syndrome', Abstracts. European Respiratory Society Annual Congress 2012 (2012) [E3]
Co-authors Jodie Simpson, Vanessa Mcdonald
2012 Scott HA, Gibson PG, Garg ML, Smart JM, Wood LG, 'Reproductive stage drives link between obesity and neutrophilic airway inflammation in females with asthma', Abstracts. TSANZ Annual Scientific Meeting 2012 (2012) [E3]
Co-authors Lisa Wood, Hayley Scott, Manohar Garg
2012 Ryan NM, Gibson PG, 'Gabapentin for idiopathic chronic cough: A randomised controlled trial', Lung (2012) [E3]
Co-authors Nicole Ryan
2012 Simpson JL, Phipps S, Baines KJ, Oreo KM, Gibson PG, 'NALP3 INFLAMMASOME ACTIVATION IN NEUTROPHILIC ASTHMA', RESPIROLOGY (2012) [E3]
Co-authors Jodie Simpson, Katherine Baines
2012 Garside CG, Simpson JL, Yang IA, Reynolds PN, Hodge SJ, James AL, et al., 'Inflammatory subtypes of uncontrolled asthma in Australia', Respirology (2012) [E3]
Co-authors Jodie Simpson
2012 McDonald VM, Fu J, Simpson JL, Gibson PG, 'The longitudinal determinants of decline in obstructive airway diseases', Respirology (2012) [E3]
Co-authors Vanessa Mcdonald, Jodie Simpson
2012 McDonald VM, Wark PA, Roberts M, Spencer LM, Alison JA, Wood LG, Gibson PG, 'Development and audience testing of a COPD education DVD', Respirology (2012) [E3]
Co-authors Lisa Wood, Vanessa Mcdonald, Peter Wark
2012 Parsons KS, Tooze MK, Grissell TV, Bell N, Chapman JN, Ryan J, et al., 'Patterns (2007-2009) of respiratory viruses isolated from acute exacerbations of airways disease', Respirology (2012) [E3]
Co-authors Peter Wark
2012 Powell HG, McCaffery K, Murphy VE, Giles W, Clifton VL, Hensley MJ, Gibson PG, 'Psychosocial outcomes are related to future exacerbation risk and perinatal outcomes in pregnant women with asthma', Respirology (2012) [E3]
Citations Web of Science - 1
Co-authors Vanessa Murphy, Vicki Clifton, Michael Hensley
2012 Simpson JL, Phipps S, Baines KJ, Oreo K, Gibson PG, 'NALP3 inflammasome activation in neutrophilic asthma', Respirology (2012) [E3]
Co-authors Jodie Simpson, Katherine Baines
2012 Suthers BG, McDonald VM, Gibson PG, 'Leptin is associated with breathlessness in obstructive airways disease (OAD)', Respirology (2012) [E3]
Co-authors Vanessa Mcdonald
2012 Wark PA, Tooze MK, Cheese L, Whitehead BF, Gibson PG, McDonald VM, 'Viral infections trigger CF exacerbations and worsen infection with P Aeruginosa in adults and children', Respirology (2012) [E3]
Co-authors Peter Wark, Vanessa Mcdonald
2012 Wood LG, Garg ML, Smart JM, Scott HA, Barker D, Gibson PG, 'Manipulating antioxidant intake in asthma: A randomized clinical trial', Respirology (2012) [E3]
Citations Web of Science - 2
Co-authors Lisa Wood, Manohar Garg, Hayley Scott
2012 Gao P, Wang L, Zhang J, Wang F, Gibson PG, 'Inflammatory cellular phenotypes in adults with acute exacerbations of chronic obstructive pulmonary disease', Respirology (2012) [E3]
2012 Brooks CR, Gibson PG, Douwes J, Van Dalen CJ, Simpson JL, 'Assessment of the relationship between airway neutrophilia and aging in asthmatics and non-asthmatics', Respirology (2012) [E3]
Co-authors Jodie Simpson
2012 Baines KJ, Simpson JL, Wood LG, Scott RJ, Gibson PG, 'Sputum gene expression of mast cell specific proteases are increased in eosinophilic asthma', Respirology (2012) [E3]
Co-authors Lisa Wood, Jodie Simpson, Katherine Baines, Rodney Scott
2012 Baines KJ, Simpson JL, Wood LG, Scott RJ, Gibson PG, 'Induced sputum differential gene expression implicates increased p38 signalling activity in severe asthma', Respirology (2012) [E3]
Co-authors Katherine Baines, Jodie Simpson, Lisa Wood, Rodney Scott
2012 Scott HA, Gibson PG, Garg ML, Pretto JJ, Morgan PJ, Callister R, Wood LG, 'Weight loss improves clinical asthma outcomes and airway inflammation in overweight and obese asthmatics', Obesity Research & Clinical Practice (2012) [E3]
Co-authors Lisa Wood, Philip Morgan, Manohar Garg, Robin Callister, Hayley Scott
2011 Berthon B, MacDonald-Wicks LK, Gibson PG, Wood LG, 'Asthmatics have an altered eating pattern with increased fat and decreased fibre intake associated with airway inflammation and poorer lung function', Australasian Medical Journal (2011) [E3]
Co-authors Lesley Wicks, Lisa Wood
2011 Berthon B, MacDonald-Wicks LK, Gibson PG, Wood LG, 'Plasma leptin levels are elevated in stable asthma', Australasian Medical Journal (2011) [E3]
Co-authors Lesley Wicks, Lisa Wood
2011 Jensen ME, Collins CE, Gibson PG, Hilton JM, Wood LG, 'Dietary induced weight loss improves asthma control and lung function after 10 weeks in obese children and adolescents with asthma', Australasian Medical Journal (2011) [E3]
Co-authors Clare Collins, Lisa Wood
2011 Jensen ME, Gibson PG, Collins CE, Wood LG, 'Lean mass is positively associated with respiratory function in male asthmatic children', Australasian Medical Journal (2011) [E3]
Co-authors Clare Collins, Lisa Wood
2011 Scott HA, Gibson PG, Garg ML, Pretto JJ, Morgan PJ, Callister R, Wood LG, 'The influence of body composition and inflammation on lung function in asthma', Australasian Medical Journal (2011) [E3]
Co-authors Philip Morgan, Robin Callister, Manohar Garg, Hayley Scott, Lisa Wood
2011 Baines KJ, Simpson JL, Scott R, Wood LG, Gibson PG, 'Systemic upregulation of neutrophil a-defensins and serine proteases in neutrophilic asthma', European Respiratory Society Annual Congress 2011 Abstracts (2011) [E3]
Co-authors Rodney Scott, Jodie Simpson, Lisa Wood, Katherine Baines
2011 Baines KJ, Simpson JL, Scott R, Wood LG, Gibson PG, 'Sputum gene expression of mast cell tryptase and carboxypeptidase A3 are increased in eosinophilic asthma', European Respiratory Society Annual Congress 2011 Abstracts (2011) [E3]
Co-authors Katherine Baines, Rodney Scott, Jodie Simpson, Lisa Wood
2011 Baines KJ, Simpson JL, Scott R, Wood LG, Gibson PG, 'Induced sputum differential gene expression implicates increased p38 signalling activity in severe asthma', European Respiratory Society Annual Congress 2011 Abstracts (2011) [E3]
Co-authors Lisa Wood, Rodney Scott, Jodie Simpson, Katherine Baines
2011 Porsbjerg C, Gibson PG, Pretto JJ, Salome C, Brown N, King G, 'Airway inflammation and airway pathophysiology in older asthmatics', European Respiratory Society Annual Congress 2011 Abstracts (2011) [E3]
2011 Namazy JA, Murphy VE, Powell H, Gibson PG, Chambers C, Schatz M, 'Effects of asthma severity and medication use on prematurity and intrauterine growth: A meta analysis from published data', Journal of Allergy and Clinical Immunology (2011) [E3]
Co-authors Vanessa Murphy
2011 Foster P, Li J, Wang W, Baines K, Bowden N, Hansbro P, et al., 'IL-27 underpins steroid resistant airway hyperresponsiveness via MyD88 dependent pathways', ALLERGY (2011) [E3]
Co-authors Philip Hansbro, Ming Yang, Nikola Bowden
2011 Gibson PG, Powell H, Giles W, Clifton V, Hensley MJ, Taylor DR, et al., 'Asthma exacerbations during pregnancy are reduced by inflammometry (FENO) guided asthma management: A randomised controlled trial', American Journal of Respiratory and Critical Care Medicine (2011) [E3]
Co-authors Michael Hensley, Vanessa Murphy
2011 Hansbro PM, Horvat JC, Essilfie A-T, Kim RY, Simpson JL, Dunkley ML, et al., 'Infection-induced neutrophilic allergic airways disease is resistant to steroid treatment', American Journal of Respiratory and Critical Care Medicine (2011) [E3]
Co-authors Margaret Dunkley, Philip Hansbro, Jodie Simpson, Paul Foster, Jay Horvat
2011 Jensen ME, Collins CE, Gibson PG, Hilton JM, Wood LG, 'Characterising the obese phenotype in asthmatic children and adolescents', American Journal of Respiratory and Critical Care Medicine (2011) [E3]
Co-authors Clare Collins, Lisa Wood
2011 Jensen ME, Gibson PG, Collins CE, Hilton JM, Latham-Smith F, Wood LG, 'Gender differences in sleep duration & sleep quality in children with & without asthma using polysomnography', American Journal of Respiratory and Critical Care Medicine (2011) [E3]
Co-authors Lisa Wood, Clare Collins
2011 Jensen ME, Gibson PG, Collins CE, Hilton JM, Wood LG, 'Results from a ten week pilot weight loss intervention in obese asthmatic children and adolescents', American Journal of Respiratory and Critical Care Medicine (2011) [E3]
Co-authors Lisa Wood, Clare Collins
2011 Scott HA, Gibson PG, Garg ML, Pretto JJ, Morgan PJ, Callister R, Wood LG, 'Clinical asthma outcomes are improved after body fat reduction in overweight and obese asthmatics', American Journal of Respiratory and Critical Care Medicine (2011) [E3]
Co-authors Robin Callister, Manohar Garg, Hayley Scott, Philip Morgan, Lisa Wood
2011 Sukkar MB, Wood LG, Tooze MK, Simpson JL, McDonald VM, Gibson PG, Wark PA, 'Deficiency of srage in asthma and COPD is selectively associated with neutrophilic airway inflammation', American Journal of Respiratory and Critical Care Medicine (2011) [E3]
Co-authors Vanessa Mcdonald, Jodie Simpson, Peter Wark, Lisa Wood
2011 Wood LG, Scott HA, Gibson PG, 'Systemic inflammation is increased in neutrophilic asthma', American Journal of Respiratory and Critical Care Medicine (2011) [E3]
Co-authors Lisa Wood, Hayley Scott
2011 Scott HA, Gibson PG, Garg ML, Pretto JJ, Morgan PJ, Callister R, Wood LG, 'Success in a weight loss trial is greatest in subjects with more severe asthma', American Journal of Respiratory and Critical Care Medicine (2011) [E3]
Co-authors Lisa Wood, Hayley Scott, Robin Callister, Philip Morgan, Manohar Garg
2011 Vertigan AE, Gibson PG, 'Development of a brief speech pathology intervention for chronic refractory cough', Pulmonary Pharmacology & Therapeutics (2011) [E3]
2011 McLaughlin KM, Mattes J, Murphy VE, Steel KR, Powell H, Gibson PG, 'The Growing Into Asthma (GIA) Study: Need for improved management of respiratory illnesses in early life', PSANZ 2011 15th Annual Congress: Poster Abstracts (2011) [E3]
Co-authors Vanessa Murphy, Joerg Mattes
2011 McDonald VM, Higgins IJ, Wood LG, Gibson PG, 'Multidimensional assessment and individualized management (MDAIM) of obstructive airway diseases (OAD) in older adults - A pilot clinical trial', Respirology (2011) [E3]
Co-authors Isabel Higgins, Lisa Wood, Vanessa Mcdonald
2011 Sukkar M, Wood LG, Tooze MK, Simpson JL, McDonald VM, Gibson PG, Wark PA, 'Soluble RAGE is deficient in neutrophilic asthma and COPD', Respirology (2011) [E3]
DOI 10.1183/09031936.00022011
Citations Scopus - 54Web of Science - 43
Co-authors Peter Wark, Lisa Wood, Vanessa Mcdonald, Jodie Simpson
2011 Baines KJ, Simpson JL, Scott R, Wood LG, Gibson PG, 'Analysis of systemic gene expression according to inflammatory phenotype of asthma', Respirology (2011) [E3]
Co-authors Lisa Wood, Katherine Baines, Rodney Scott, Jodie Simpson
2011 Berthon B, MacDonald-Wicks LK, Gibson PG, Wood LG, 'Diet quality is poor in severe asthmatics compared to healthy controls', Respirology (2011) [E3]
Co-authors Lisa Wood, Lesley Wicks
2011 Vanders RL, Gibson PG, Murphy VE, Wark PA, 'Reduced antiviral interferons during pregnancy explains susceptibility to influenza virus infection', Respirology (2011) [E3]
Co-authors Vanessa Murphy, Peter Wark
2011 Garside CG, Simpson JL, Yang IA, James AL, Upham JW, Reynolds PN, et al., 'Characterizing the severe asthma phenotype in an Australian setting: The Amazes Study', Respirology (2011) [E3]
Co-authors Jodie Simpson
2011 Gunawardhana LP, Baines KJ, Simpson JL, Mattes J, Murphy VE, Gibson PG, 'Maternal asthma is associated with alterations in DNA methylation profile of peripheral blood of infants', Respirology (2011) [E3]
Co-authors Vanessa Murphy, Joerg Mattes, Jodie Simpson, Katherine Baines
2011 Hodge S, Richard S, Simpson JL, Garside CG, Herewane K, Yang I, et al., 'Granzyme B is increased in induced sputum both from patients with COPD and non-eosinophilic asthma', Respirology (2011) [E3]
Co-authors Jodie Simpson
2011 Hodge S, Simpson JL, Richard S, Garside CG, Yang I, Upham J, et al., 'Non-eosinophilic asthma resembles COPD with suppressed apoptotic cell clearance and macrophage recognition molecules', Respirology (2011) [E3]
Co-authors Jodie Simpson
2011 Horvat JC, Essilfie A-T, Kim RY, Simpson JL, Dunkley ML, Beagley KW, et al., 'Investigation of infection-induced steroid resistant asthma', Respirology (2011) [E3]
Co-authors Paul Foster, Jay Horvat, Jodie Simpson, Margaret Dunkley, Philip Hansbro
2011 Mattes J, Murphy VE, McLaughlin KM, Steel KR, Powell H, Gibson PG, 'Are maternal asthma exacerbations during pregnancy related to impaired infant growth in the first six months of life?', Respirology (2011) [E3]
Co-authors Vanessa Murphy, Joerg Mattes
2011 Oreo K, Baines KJ, Gibson PG, Hansbro PM, 'Pro-inflammatory cytokine production is impaired in response to TLR2 activation in healthy ageing and COPD', Respirology (2011) [E3]
Co-authors Katherine Baines, Philip Hansbro
2011 Ryan NM, Vertigan AE, Ferguson JK, Wark PA, Gibson PG, 'Investigation and characterization of persistent cough associated with H1N1 2009 influenza', Respirology (2011) [E3]
Co-authors Nicole Ryan, Peter Wark, John Ferguson
2011 Scott HA, Gibson PG, Garg ML, Pretto JJ, Morgan PJ, Callister R, Wood LG, 'Success in a weight loss trial is related to asthma severity', Respirology (2011) [E3]
Co-authors Philip Morgan, Robin Callister, Manohar Garg, Hayley Scott, Lisa Wood
2011 Scott HA, Gibson PG, Garg ML, Pretto JJ, Morgan PJ, Callister R, Wood LG, 'Body fat reduction improves clinical asthma outcomes in overweight and obese asthma', Respirology (2011) [E3]
Co-authors Lisa Wood, Philip Morgan, Robin Callister, Manohar Garg, Hayley Scott
2011 Wood LG, Scott HA, Gibson PG, 'The neutrophilic inflammatory phenotype is associated increased systemic inflammation in asthma', Respirology (2011) [E3]
Co-authors Hayley Scott, Lisa Wood
2011 Wang F, Xy HA, Baines KJ, Gunawardhana LP, Simpson JL, Ki F, Gibson PG, 'Is chalamydophyla a pneumoniae infection related to non-eosinophilic asthma?', Respirology (2011) [E3]
Co-authors Jodie Simpson, Katherine Baines
2011 Fu J, Baines KJ, Wood LG, Scott HA, Gibson PG, 'Low-grade systemic inflammation is associated with airway neutrophilia in asthma', Respirology (2011) [E3]
Co-authors Katherine Baines, Hayley Scott, Lisa Wood
2011 Fu J, Baines KJ, Gibson PG, Scott HA, Wood LG, 'Systemic inflammation mediates airway neutrophilia via the regulation of IL-8 receptor mRNA expression', Respirology (2011) [E3]
Co-authors Katherine Baines, Hayley Scott, Lisa Wood
2011 McDonald VM, Simpson JL, Higgins IJ, Gibson PG, 'Mucus hypersecretion and chronic bronchitis in older adults with chronic obstructive airway diseases', Respirology (2011) [E3]
Co-authors Vanessa Mcdonald, Isabel Higgins, Jodie Simpson
2011 Gao P, Zhang J, He X, Wang K, Hao Y, Liu H, Gibson PG, 'The safety of sputum induction in adults with acute exacerbation of COPD', Respirology (2011) [E3]
2011 Wood LG, Garg ML, Gibson PG, 'Dietary fat increases airway inflammation and attenuates bronchodilator response in asthma', XI Asian Congress of Nutrition 2011 (2011) [E3]
Co-authors Manohar Garg, Lisa Wood
2010 Scott HA, Gibson PG, Garg ML, Smart JM, Wood LG, 'Fatty acids and obesity differentially affect airway inflammation in males and females with asthma', American Journal of Respiratory and Critical Care Medicine (2010) [E3]
Co-authors Hayley Scott, Manohar Garg, Lisa Wood
2010 Murphy VE, Namazy JA, Powell GH, Gibson PG, Chambers C, Attia JR, Schatz M, 'A meta-analysis of adverse perinatal outcomes in asthmatic women: Effect of asthma on placental and neonatal outcomes', American Journal of Respiratory and Critical Care Medicine (2010) [E3]
Co-authors John Attia, Vanessa Murphy
2010 Hansbro PM, Essilfie A-T, Simpson JL, Dunkley ML, Horvat JC, Gibson PG, Foster PS, 'Haemophilus influenzae induces IL-17-mediated neutrophilic allergic airways disease', American Journal of Respiratory and Critical Care Medicine (2010) [E3]
Citations Scopus - 53Web of Science - 37
Co-authors Paul Foster, Jodie Simpson, Philip Hansbro, Margaret Dunkley, Jay Horvat
2010 Thorburn AN, Foster PS, Gibson PG, Hansbro PM, 'Development of a streptococcus pneumoniae-based immunoregulatory therapy for asthma', American Journal of Respiratory and Critical Care Medicine (2010) [E3]
Co-authors Philip Hansbro, Paul Foster
2010 Thorburn AN, Foster PS, Gibson PG, Hansbro PM, 'Streptococcus pneumoniae vaccine, prevenar, induces regulatory T cells and prevents allergic airways disease', American Journal of Respiratory and Critical Care Medicine (2010) [E3]
Co-authors Philip Hansbro, Paul Foster
2010 Wood LG, Garg ML, Wood A, Gibson PG, 'A high fat challenge enhances innate immune responses in asthmatic airways', American Journal of Respiratory and Critical Care Medicine (2010) [E3]
Co-authors Lisa Wood, Manohar Garg
2010 Namazy JA, Murphy VE, Powell HG, Gibson PG, Chambers CD, Schatz M, 'Congenital anomalies in asthmatic women using corticosteroids during pregnancy: A meta analysis from published data', Birth Defects Research (Part A) (2010) [E3]
Co-authors Vanessa Murphy
2010 Scott HA, Gibson PG, Garg ML, Pretto JJ, Morgan PJ, Callister R, Wood LG, 'Caloric restriction and exercise improve clinical asthma outcomes in overweight and obese asthma', Obesity Research & Clinical Practice (2010) [E3]
Co-authors Robin Callister, Philip Morgan, Manohar Garg, Hayley Scott, Lisa Wood
2010 Jensen ME, Gibson PG, Collins CE, Hilton JM, Wood LG, 'Body composition may be associated with systemic and airway inflammation in children with asthma', Obesity Research and Clinical Practice (2010) [E3]
Co-authors Lisa Wood, Clare Collins
2010 Scott HA, Gibson PG, Garg ML, Pretto JJ, Morgan PJ, Callister R, Wood LG, 'Caloric consumption and exercise improve clinical asthma outcomes in overweight and obese asthma', Obesity Research and Clinical Practice (2010) [E3]
Co-authors Hayley Scott, Manohar Garg, Lisa Wood, Philip Morgan, Robin Callister
2010 Hodyl NA, Smith R, Bisits AM, Gibson PG, Clifton VL, 'The effect of inhaled corticosteroids on maternal and fetal systemic function and placental activity in women with asthma', Reproductive Sciences (2010) [E3]
DOI 10.1177/193371912010173s003
Co-authors Roger Smith, Vicki Clifton
2010 Irwin J, Verrills NM, He XY, Powell H, Wood LG, Gibson PG, 'Proteomic biomarkers as novel clinical diagnostics for airway disease', Abstract Book. Human Proteome World Congress Sydney 2010 (2010) [E3]
Co-authors Lisa Wood, Nikki Verrills
2010 Baines KJ, Simpson JL, Scott R, Wood LG, Gibson PG, 'Molecular phenotypes of asthma defined by gene expression profiling', American Journal of Respiratory and Critical Care Medicine (2010) [E3]
Co-authors Rodney Scott, Jodie Simpson, Katherine Baines, Lisa Wood
2010 Baines KJ, Simpson JL, Scott R, Wood LG, Gibson PG, 'Analysis of systemic gene expression according to inflammatory phenotype of asthma', Biomarker Discovery Conference (2010) [E3]
Co-authors Katherine Baines, Rodney Scott, Lisa Wood, Jodie Simpson
2010 Scott HA, Gibson PG, Garg ML, Pretto JJ, Morgan PJ, Callister R, Wood LG, 'Clinical asthma outcomes are improved by caloric restriction and exercise in overweight and obese asthma', Proceedings of the Nutrition Society of Australia (2010) [E3]
Co-authors Robin Callister, Manohar Garg, Hayley Scott, Philip Morgan, Lisa Wood
2010 McDonald VM, Higgins IJ, Simpson JL, Gibson PG, 'Is there an association between self reported activity limitation and exercise tolerance in COPD?', European Respiratory Society Annual Congress 2010. Abstracts (2010) [E3]
Co-authors Vanessa Mcdonald, Isabel Higgins, Jodie Simpson
2010 McDonald VM, Higgins IJ, Simpson JL, Gibson PG, 'Six minute walk tests: Are practice tests necessary?', European Respiratory Society Annual Congress 2010. Abstracts (2010) [E3]
Co-authors Vanessa Mcdonald, Isabel Higgins, Jodie Simpson
2010 McDonald VM, Higgins IJ, Wood LG, Gibson PG, 'Multidimensional assessment and individualised management of obstructive airway diseases (OAD) in older adults', European Respiratory Society Annual Congress 2010. Abstracts (2010) [E3]
Co-authors Lisa Wood, Isabel Higgins, Vanessa Mcdonald
2010 Namazy JA, Murphy VE, Powell HG, Gibson PG, Chambers C, Schatz M, 'Adverse perinatal outcomes in asthmatic women: A meta analysis from published data', Journal of Allergy and Clinical Immunology (2010) [E3]
Co-authors Vanessa Murphy
2010 McLaughlin KM, Steel KR, McCaffery K, Powell HG, Clifton VL, Giles W, et al., 'Psychosocial characteristics and perceived medication risk in pregnant women and asthma', Journal of Paediatrics and Child Health: Abstracts of the 14th Annual Congress of the Perinatal Society of Australia and New Zealand 2010 (2010) [E3]
Co-authors Michael Hensley, Vicki Clifton
2010 Vanders RL, Gibson PG, Murphy VE, Wark PA, 'Reduced anti-viral responses: Why pregnant women have increased susceptibility to respiratory virus infection', American Journal of Respiratory and Critical Care Medicine (2010) [E3]
Co-authors Vanessa Murphy, Peter Wark
2010 Baines KJ, Simpson JL, Scott RJ, Wood LG, Gibson PG, 'Molecular profiling of asthma defined by gene expression', Respirology (2010) [E3]
Co-authors Jodie Simpson, Lisa Wood
2010 Baines KJ, Simpson JL, Scott R, Wood LG, Gibson PG, 'Molecular phenotypes of asthma defined by gene expression profiling', Respirology (2010) [E3]
Co-authors Katherine Baines, Rodney Scott, Lisa Wood, Jodie Simpson
2010 Vanders RL, Gibson PG, Murphy VE, Wark PA, 'Reduced anti-viral responses: Why pregnant women have increased susceptiblty to respiratory virus infection', Respirology (2010) [E3]
Co-authors Vanessa Murphy, Peter Wark
2010 Jensen ME, Collins CE, Gibson PG, Hilton JM, Wood LG, 'Obesity is associated with increased airway inflammation in children with asthma', Respirology (2010) [E3]
Co-authors Clare Collins, Lisa Wood
2010 McDonald VM, Simpson JL, Higgins IJ, Gibson PG, 'Is there an association between self reported acitivity limitation and exercise tolerance in COPD?', Respirology (2010) [E3]
Co-authors Vanessa Mcdonald, Isabel Higgins, Jodie Simpson
2010 Murphy VE, Namazy J, Powell GH, Gibson PG, Chambers C, Attia JR, Schatz M, 'A meta-analysis of adverse perinatal outcomes in asthmatic women: Effect of asthma on maternal and neonatal outcomes', Respirology (2010) [E3]
Co-authors John Attia, Vanessa Murphy
2010 Murphy VE, Namazy J, Powell GH, Schatz M, Chambers C, Attia JR, Gibson PG, 'A meta-analysis of adverse perinatal outcomes in asthmatic women: Effect of asthma on size at birth and timing of birth', Respirology (2010) [E3]
Co-authors Vanessa Murphy, John Attia
2010 Ryan NM, Vertigan AE, Bone S, Gibson PG, 'Cough reflex sensitivity improves with speech language pathology management of refractory chronic cough', Respirology (2010) [E3]
DOI 10.1186/1745-9974-6-5
Co-authors Nicole Ryan
2010 Simpson JL, McDonald VM, Gibson PG, 'The relationship between systemic inflammation, airway inflammation and airway obstruction in COPD', Respirology (2010) [E3]
Co-authors Vanessa Mcdonald, Jodie Simpson
2010 Simpson JL, McDonald VM, Gibson PG, 'Exhaled nitric oxide is not a marker of eosinophilic inflammation in older Australians', Respirology (2010) [E3]
Co-authors Vanessa Mcdonald, Jodie Simpson
2010 Steel KR, McLaughlin KM, McCaffery K, Powell GH, Clifton VL, Giles W, et al., 'Psychosocial characteristics and perceived medication risk in pregnant women with asthma', Respirology (2010) [E3]
Co-authors Michael Hensley
2010 Wood LG, Garg ML, Wood A, Gibson PG, 'Dietary fat enhances airway inflammation in asthma', Respirology (2010) [E3]
Co-authors Lisa Wood, Manohar Garg
2010 Yan X, He S, Gangireddy SR, Gibson PG, Wark PA, 'Monocyte derived dendritic cells from COPD patients and their therapeutic potential', Respirology (2010) [E3]
Co-authors Peter Wark
2010 Jensen ME, Collins CE, Gibson PG, Hilton JM, Wood LG, 'Obesity affects airway inflammation in asthmatic children', Nutrition & Dietetics (2010) [E3]
Co-authors Lisa Wood, Clare Collins
2009 Baines KJ, Simpson JL, Scott R, Wood LG, Gibson PG, 'Genome wide gene expression of induced sputum in non-eosinophilic asthma', AMATA 2009 (2009) [E3]
Co-authors Rodney Scott, Jodie Simpson, Katherine Baines, Lisa Wood
2009 Hansbro PM, Starkey MR, Horvat JC, Kim RY, Phipps S, Gibson PG, Foster PS, 'Early life chlamydial infection enhances allergic airways disease through age-dependent differences in immunopathology', Journal of Immunology (2009) [E3]
DOI 10.1016/j.jaci.2009.10.018
Co-authors Philip Hansbro, Paul Foster, Jay Horvat, Malcolm Starkey
2009 Hansbro PM, Thorburn AN, Foster PS, Gibson PG, 'Streptococcus pneumoniae vaccine, Prevenar, utilises Tregs to suppress asthma', Journal of Immunology (2009) [E3]
Co-authors Paul Foster, Philip Hansbro
2009 Horvat JC, Starkey MR, Beagley KW, Gibson PG, Foster PS, Hansbro PM, 'Chlamydial respiratory infection predisposes to neutrophil dominated allergic airways disease (AAD)', Journal of Immunology (2009) [E3]
Co-authors Paul Foster, Jay Horvat, Malcolm Starkey, Philip Hansbro
2009 Scott HA, Gibson PG, Garg ML, Smart JM, Wood LG, 'Plasma fatty acid profiles are different in obese versus non-obese asthma', Proceedings of the Nutrition Society of Australia (2009) [E3]
Co-authors Lisa Wood, Hayley Scott, Manohar Garg
2009 Wood LG, Gibson PG, 'Antioxidant defences are impaired in asthmatics with airway hyperresponsiveness, poor control and severe disease pattern', Proceedings of the Nutrition Society of Australia (2009) [E3]
Co-authors Lisa Wood
2009 Wood AJ, Gibson PG, Wood LG, 'Effects of a high fat, high energy food challenge on mood, fatigue and gastrointestinal symptoms', Proceedings of the Nutrition Society of Australia (2009) [E3]
Co-authors Lisa Wood
2009 McDonald VM, Wood LG, Smart JM, Higgins IJ, Gibson PG, 'Sacropenia and sarcopenic obesity in older people with COPD?', Proceedings of the Nutrition Society of Australia (2009) [E3]
Co-authors Lisa Wood, Vanessa Mcdonald, Isabel Higgins
2009 McDonald VM, McElduff P, Simpson JL, Higgins IJ, Gibson PG, 'Multidimensional problem assessment of asthma and COPD in an older population: Patient-physician concordance', European Respiratory Journal (2009) [E3]
Co-authors Vanessa Mcdonald, Isabel Higgins, Jodie Simpson
2009 McDonald VM, Wood LG, Smart J, Higgins I, Gibson PG, 'An Investigation of Sarcopenic Obesity in COPD.', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2009) [E3]
Co-authors Isabel Higgins, Lisa Wood, Vanessa Mcdonald
2009 Scott HA, Gibson PG, Garg ML, Smart J, Wood LG, 'Neutrophilic Airway Inflammation Links Asthma and Obesity', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2009) [E3]
Co-authors Lisa Wood, Manohar Garg, Hayley Scott
2009 McDonald VM, Wood LG, Smart JM, Higgins IJ, Gibson PG, 'Does sarcopenic obesity exist in older people with COPD?', Respirology (2009) [E3]
DOI 10.1111/j.1440-1843.2009.01503_1.x
Co-authors Isabel Higgins, Vanessa Mcdonald, Lisa Wood
2009 McDonald VM, McElduff P, Simpson JL, Higgins IJ, Gibson PG, 'Multidimensional clinical problem assessment in asthma and COPD: Patient-physician concordance', Respirology (2009) [E3]
DOI 10.1111/j.1440-1843.2009.01502_7.x
Co-authors Vanessa Mcdonald, Isabel Higgins, Jodie Simpson
2009 Murphy VE, Clifton VL, Gibson PG, 'The effect of cigarette smoking on asthma control and exacerbations in pregnant women', Respirology (2009) [E3]
DOI 10.1111/j.1440-1843.2009.01503_1.x
Co-authors Vanessa Murphy
2009 Oldham RA, Simpson JL, Hansbro PM, Gibson PG, 'Increased bacterial load and colonisation in COPD', Respirology (2009) [E3]
DOI 10.1111/j.1440-1843.2009.01503_1.x
Co-authors Jodie Simpson, Philip Hansbro
2009 Wark PA, Parsons KS, Ryan J, Grissell T, Bell N, Chapman JN, Gibson PG, 'Seasonal patterns (2004-2007) of respiratory viruses isolated with acute airways disease', Respirology (2009) [E3]
DOI 10.1111/j.1440-1843.2009.01503_1.x
Co-authors Peter Wark
2009 Twaddell S, Loewenthal MR, Gibson PG, Saltos N, Wark PA, 'Individualised aminoglycoside dosing in adult patients with cystic fibrosis improves pharmacokinetic parameters', Respirology (2009) [E3]
DOI 10.1111/j.1440-1843.2009.01503_1.x
Co-authors Peter Wark
2009 Thorburn AN, O'Sullivan B, Thomas R, Foster PS, Gibson PG, Hansbro PM, 'Prevenar suppresses allergic airways disease through the expansion of regulatory T cells', Respirology (2009) [E3]
DOI 10.1111/j.1440-1843.2009.01503_1.x
Co-authors Philip Hansbro, Paul Foster
2009 Simpson JL, Gibson PG, Reynolds PN, Hodge S, 'Impaired macrophage phagocytosis in non-eosinophilic asthma', Respirology (2009) [E3]
DOI 10.1111/j.1440-1843.2009.01503_1.x
Co-authors Jodie Simpson
2009 Baines KJ, Grissell TV, Gibson PG, Wark PA, 'Molecular mechanisms of rhinovirus infection of primary bronchial epithelial cells', Respirology (2009) [E3]
DOI 10.1111/j.1440-1843.2009.01503_1.x
Co-authors Peter Wark, Katherine Baines
2009 Baines KJ, Wood LG, Gibson PG, 'Molecular mechanisms of airway neutrophilia following a low antioxidant diet', Respirology (2009) [E3]
DOI 10.1111/j.1440-1843.2009.01503_1.x
Co-authors Katherine Baines, Lisa Wood
2009 Scott HA, Gibson PG, Garg ML, Smart JM, Wood LG, 'Asthma and obesity are linked via neutrophilic airway inflammation', Respirology (2009) [E3]
DOI 10.1111/j.1440-1843.2009.01503_1.x
Co-authors Hayley Scott, Manohar Garg, Lisa Wood
2009 Oreo K, Baines KJ, Gibson PG, Hansbro PM, Simpson JL, 'Toll-like receptor agonists stimulate cytokine release from blood but not airway cells', Respirology (2009) [E3]
DOI 10.1111/j.1440-1843.2009.01503_1.x
Co-authors Jodie Simpson, Philip Hansbro, Katherine Baines
2009 Essilfie A-T, Simpson JL, Dunkley ML, Foster PS, Gibson PG, Hansbro PM, 'Haemophilus influenzae infection induces features of neutrophilic asthma', Respirology (2009) [E3]
DOI 10.1111/j.1440-1843.2009.01503_1.x
Co-authors Jodie Simpson, Philip Hansbro, Paul Foster, Margaret Dunkley
2009 Thomas R, Ferguson JK, Gibson PG, 'Community acquired methicillin resistant staphylococcus aureus pneumonia: A clinical audit', Respirology (2009) [E3]
DOI 10.1111/j.1440-1843.2009.01502_7.x
Co-authors John Ferguson
2009 Powell H, Murphy VE, Gibson PG, 'The relationship between feno and atopic status in pregnant women with asthma', Respirology (2009) [E3]
DOI 10.1111/j.1440-1843.2009.01503_1.x
Co-authors Vanessa Murphy
2009 Wood LG, Garg ML, Smith AJ, Smart JM, Gibson PG, 'A high fat, high energy food challenge induces an exaggerated inflammatory response in asthma', Respirology (2009) [E3]
DOI 10.1111/j.1440-1843.2009.01503_1.x
Co-authors Lisa Wood, Manohar Garg
2009 Horvat JC, Starkey MR, Beagley KW, Preston JA, Gibson PG, Foster PS, Hansbro PM, 'Neutrophil influx during chlamydial lung infection determines the phenotype of allergic airways disease (AAD)', Respirology (2009) [E3]
DOI 10.1111/j.1440-1843.2009.01503_1.x
Co-authors Malcolm Starkey, Philip Hansbro, Jay Horvat, Paul Foster
2009 Starkey MR, Horvat JC, Kim RY, Phipps S, Gibson PG, Beagley KW, et al., 'Early life chlamydial lung infection enhances allergic airways disease through age-dependent differences in immunopathology', Respirology (2009) [E3]
DOI 10.1016/j.jaci.2009.10.018
Citations Scopus - 53Web of Science - 48
Co-authors Malcolm Starkey, Philip Hansbro, Paul Foster, Jay Horvat
2009 McLaughlin KM, Murphy VE, McCaffery K, Powell H, Clifton VL, Giles W, et al., 'The relationship between patient perceived risk of inhaled corticosteroids in pregnancy and medication adherence', Respirology (2009) [E3]
Co-authors Vanessa Murphy, Michael Hensley
2008 Hansbro PM, Essilfie A-T, Foster PS, Gibson PG, 'Haemophilus influenzae (Hi) infection in asthma may drive the development of neutrophilic asthma (NA)', American Journal of Respiratory and Critical Care Medicine (2008) [E3]
Co-authors Paul Foster, Philip Hansbro
2008 Hansbro PM, Horvat JC, Beagley KW, Gibson PG, Foster PS, 'Neutrophil influx during chlamydial lung infection determines the phenotype of allergic airways disease', American Journal of Respiratory and Critical Care Medicine (2008) [E3]
Co-authors Philip Hansbro, Jay Horvat, Paul Foster
2008 Hansbro PM, Thorburn AN, Foster PS, Gibson PG, 'Streptococcus Pneumoniae vaccine prevenar: A potential therapy for the suppression of asthma', American Journal of Respiratory and Critical Care Medicine (2008) [E3]
Co-authors Philip Hansbro, Paul Foster
2008 Simpson JL, Hansbro PM, McDonald VM, Gibson PG, 'Age and disease related changes in airway inflammation and inflammatory subtype in older people with COPD', American Journal of Respiratory and Critical Care Medicine (2008) [E3]
Co-authors Philip Hansbro, Jodie Simpson, Vanessa Mcdonald
2008 Murphy VE, Clifton VL, Gibson PG, 'Characterization of asthma control and airway inflammation during exacerbations in pregnancy', American Journal of Respiratory and Critical Care Medicine (2008) [E3]
Co-authors Vanessa Murphy, Vicki Clifton
2008 Nguyen TD, Hensley MJ, Whitehead BF, Gibson PG, 'Influence of passive smoking on airway inflammation in children with asthma', American Journal of Respiratory and Critical Care Medicine (2008) [E3]
Co-authors Michael Hensley
2008 Nguyen TD, Hensley MJ, Whitehead BF, Gibson PG, 'Airway inflammatory phenotypes in children with asthma', American Journal of Respiratory and Critical Care Medicine (2008) [E3]
Co-authors Michael Hensley
2008 Baines KJ, Simpson JL, Scott R, Gibson PG, 'Ageing alters airway and circulating neutrophil function', Respirology (2008) [E3]
DOI 10.1111/j.1440-1843.2008.01252.x
Co-authors Jodie Simpson, Rodney Scott, Katherine Baines
2008 Baines KJ, Simpson JL, Scott R, Gibson PG, 'Innate immune responses of airway neutrophils are impaired in neutrophilic asthma', Respirology (2008) [E3]
DOI 10.1111/j.1440-1843.2008.01252.x
Co-authors Rodney Scott, Jodie Simpson, Katherine Baines
2008 Thorburn AN, Foster PS, Gibson PG, Hansbro PM, 'Streptococcus pneumoniae vaccine prevenar: A potential therapy for the suppression of asthma', Respirology (2008) [E3]
DOI 10.1111/j.1440-1843.2008.01252.x
Co-authors Paul Foster, Philip Hansbro
2008 Horvat JC, Beagley KW, Gibson PG, Foster PS, Hansbro PM, 'Neutrophil influx during chlamydial lung infection determines the phenotype of allergic airways disease', Respirology (2008) [E3]
DOI 10.1111/j.1440-1843.2008.01252.x
Co-authors Philip Hansbro, Paul Foster, Jay Horvat
2008 Essilfie A-T, Preston JA, Horvat JC, Dunkley ML, Foster PS, Gibson PG, et al., 'Haemophilus influenzae (Hi) infection in asthma may drive the development of neutrophilic asthma (NA)', Respirology (2008) [E3]
DOI 10.1111/j.1440-1843.2008.01252.x
Co-authors Jay Horvat, Paul Foster, Jodie Simpson, Philip Hansbro, Margaret Dunkley
2008 Simpson JL, Hansbro PM, McDonald VM, Gibson PG, 'Age and disease related changes in airway inflammation in older people with COPD', Respirology (2008) [E3]
DOI 10.1111/j.1440-1843.2008.01252.x
Co-authors Vanessa Mcdonald, Jodie Simpson, Philip Hansbro
2008 Powell H, Gibson PG, 'The efficacy of using LABA/ICS combination therapy as part of a written asthma action plan', Respirology (2008) [E3]
DOI 10.1111/j.1440-1843.2008.01252.x
2008 Marchant JM, Gibson PG, Grissell TV, Masters IB, Chang AB, 'Paediatric chronic cough: The role of protracted bronchitis', Respirology (2008) [E3]
2008 McDonald VM, Higgins IJ, Gibson PG, 'The use of qualitative interviews to gain insight into older people with COPD and asthma', Respirology (2008) [E3]
DOI 10.1111/j.1440-1843.2008.01251.x
Co-authors Vanessa Mcdonald, Isabel Higgins
2008 McDonald VM, Simpson JL, Higgins IJ, Gibson PG, 'A problem based assessment of asthma and COPD in an older population', Respirology (2008) [E3]
DOI 10.1111/j.1440-1843.2008.01252.x
Co-authors Jodie Simpson, Vanessa Mcdonald, Isabel Higgins
2008 Leadbeater KE, Daugherty BR, Gibson PG, 'Treatment of gastro-oesophageal reflux does not improve asthma outcomes: A systematic review', Respirology (2008) [E3]
DOI 10.1111/j.1440-1843.2008.01252.x
2008 Wood LG, Garg ML, Smith AJ, Smart JM, Gibson PG, 'A high fat challenge activates the innate immune response in asthma', Asia Pacific Journal of Clinical Nutrition (2008) [E3]
Co-authors Lisa Wood, Manohar Garg
2008 Wood LG, Attia JR, McElduff P, McEvoy MA, Flood V, Gibson PG, 'Dietary fat and an activated innate immune response are associated with reduced FEV1', Asia Pacific Journal of Clinical Nutrition (2008) [E3]
Co-authors Mark Mcevoy, John Attia, Lisa Wood
2008 Scott HA, Gibson PG, Garg ML, Smart JM, Wood LG, 'Obesity is associated with increased inflammation in asthma', Asia Pacific Journal of Clinical Nutrition (2008) [E3]
Co-authors Manohar Garg, Hayley Scott, Lisa Wood
2008 Jackson B, Powell H, Wood LG, Gibson PG, 'A comparison of two real-time nitric oxide analysers', Asia Pacific Journal of Clinical Nutrition (2008) [E3]
Co-authors Lisa Wood
2008 Hansbro PM, Essilfie A-T, Simpson JL, Dunkley ML, Gibson PG, Foster PS, 'Haemophilus influenzae (HI) infection induces features of neutrophilic asthma', Australasian Society for Immunology 38th Annual Scientific Meeting: Delegate Book (2008) [E3]
Co-authors Philip Hansbro, Jodie Simpson, Paul Foster, Margaret Dunkley
2008 Starkey MR, Horvat JC, Kim RY, Phipps S, Gibson PG, Beagley KW, et al., 'Early life chlamydial lung infection enhances allergic airways disease through age-dependent differences in immunopathology', Australasian Society for Immunology 38th Annual Scientific Meeting: Delegate Book (2008) [E3]
Co-authors Philip Hansbro, Malcolm Starkey, Jay Horvat, Paul Foster
2008 Thorburn AN, O'Sullivan BJ, Thomas R, Foster PS, Gibson PG, Hansbro PM, 'Suppression of allergic airways disease by the Streptococcus pneumoniae vaccine prevenar through the induction of regulatory T cells', Australasian Society for Immunology 38th Annual Scientific Meeting: Delegate Book (2008) [E3]
Co-authors Philip Hansbro, Paul Foster
2008 McLaughlin K, Murphy VE, McCaffery K, Powell H, Clifton V, Giles W, et al., 'The relationship between patient perceived risk of inhaled corticosteroids in pregnancy and medication adherence', Australian Asthma Conference 2008: Conference Program & Abstract Book (2008) [E3]
Co-authors Vanessa Murphy
2007 Horvat JC, Preston JA, Gibson PG, Beagley KW, Foster PS, Hansbro PM, 'Development of allergic airways disease (AAD) is differentially affected by the timing of chlamydial infection relative to allergic sensitization', American Journal of Respiratory and Critical Care Medicine (2007) [E3]
Co-authors Paul Foster, Jay Horvat, Philip Hansbro
2007 Horvat JC, Garside CG, Wade MA, Preston JA, Hansbro NG, Gibson PG, et al., 'Development of allergic airways disease is differentially affected by chlamydial respiratory infection at different ages', American Journal of Respiratory and Critical Care Medicine (2007) [E3]
Co-authors Nicole Hansbro, Jay Horvat, Paul Foster, Philip Hansbro
2007 Baines KJ, Bowden NA, Scott R, Simpson JL, Gibson PG, 'Molecular analysis of neutrophils in asthma subtypes', Respirology (TSANZ Abstracts-Posters) (2007) [E3]
DOI 10.1111/j.1440-1843.2007.001050.x
Co-authors Nikola Bowden, Katherine Baines, Rodney Scott, Jodie Simpson
2007 Collins CE, McDonald VM, Whitehead BF, Gibson PG, 'John Hunter Cystic Fibrosis Cohort 1993-2005', 7th Australasian Cystic Fibrosis Conference. Book of Abstracts (2007) [E3]
Co-authors Vanessa Mcdonald, Clare Collins
2007 Wark PA, See HV, Oldham R, Timmins N, Gibson PG, Hansbro PM, 'Response by peripheral blood monocytes (PBMCs) to rhinovirus (RV) is greater in cells exposed to infected epithelium in coculture than exposed to RV alone', American Journal of Respiratory and Critical Care Medicine (American Thoracic Society 2007 International Conference Abstracts) (2007) [E3]
Co-authors Philip Hansbro, Peter Wark
2007 Wark PA, Grissell TV, Davies B, Mimica J, Oldham R, Shafren DR, Gibson PG, 'Bronchial epithelial cell (BEC) response to clinical rhinovirus (clin-RV) isolates from ASTHMATICS compared to laboratory (lab-RV) strains', American Journal of Respiratory and Critical Care Medicine (American Thoracic Society 2007 International Conference Abstracts) (2007) [E3]
Co-authors Peter Wark
2007 Saedi Some Olia A, Garg ML, Wood LG, Wark PA, Gibson PG, 'Lycopene enrichment of cultured epithelial airway cells', Asia Pacific Journal of Clinical Nutrition (2007) [E3]
Co-authors Manohar Garg, Lisa Wood, Peter Wark
2007 McDonald VM, Simpson JL, Higgins IJ, Gibson PG, 'A problem based assessment of obstructive airways disease (OAD) in an elderly population', European Respiratory Society Annual Congress 2007. Abstracts (2007) [E3]
Co-authors Vanessa Mcdonald, Isabel Higgins, Jodie Simpson
2007 Essiflie A, Preston JA, Horvat JC, Dunkley ML, Foster PS, Gibson PG, et al., 'Elucidating the association between Haemophilus influenzae infection and neutrophilic allergic airways disease using mouse models', Immuno 2007: 13th International Congress of Immunology. Abstracts and Posters (2007) [E3]
Co-authors Margaret Dunkley, Jay Horvat, Philip Hansbro, Jodie Simpson, Paul Foster
2007 Saedi Some Olia A, Garg ML, Wood LG, Gibson PG, Wark PA, 'Anti-inflammatory effect of lycopene enrichment on infected cultured airway epithelial cells', Respirology (Abstracts of the 12th Congress of the Asian Pacific Society of Respirology) (2007) [E3]
Co-authors Peter Wark, Lisa Wood, Manohar Garg
2007 Gibson PG, 'The overlap syndrome of asthma and COPD in older people: What are its features and how important is it?', Respirology (Abstracts of the 12th Congress of the Asian Pacific Society of Respirology) (2007) [E3]
2007 Powell H, Smart J, Wood LG, Gibson PG, 'Validity of the common cold questionnaire V(CCQ) in asthma exacerbations', Respirology (TSANZ Abstracts-Posters) (2007) [E3]
Citations Scopus - 11Web of Science - 7
Co-authors Lisa Wood, Michael Hensley
2007 Horvat JC, Moller CG, Wade MA, Preston JA, Hansbro NG, Gibson PG, et al., 'Allergic airways disease (AAD) is differentially affected by chlamydial lung infection at different stages of life', Respirology (TSANZ Abstracts-Posters) (2007) [E3]
DOI 10.1111/j.1440-1843.2007.001050.x
Co-authors Jay Horvat, Paul Foster, Philip Hansbro, Nicole Hansbro
2007 Horvat JC, Preston JA, Gibson PG, Beagley KW, Foster PS, Hansbro PM, 'Timing of chlamydial infection relative to allergen exposure differentially affects allergic airways disease', Respirology (TSANZ Abstracts-Posters) (2007) [E3]
Co-authors Jay Horvat, Paul Foster, Philip Hansbro
2007 Murphy VE, Clifton VL, Gibson PG, 'Fractional exhaled nitric oxide (FENO) in pregnant women with and without asthma', Respirology (TSANZ Abstracts-Posters) (2007) [E3]
Co-authors Vanessa Murphy, Vicki Clifton
2007 Nguyen T, Hensley MJ, Whitehead BF, Gibson PG, 'Asthma in children: Influence of passive smoking on airway inflammation', Respirology (TSANZ Abstracts-Posters) (2007) [E3]
Co-authors Michael Hensley
2007 Powell H, Ryan N, Taramarcaz P, Gibson PG, 'Development and validation of a vocal cord dysfunction questionnaire', Respirology (TSANZ Abstracts-Posters) (2007) [E3]
2007 Ryan N, Gibson PG, 'Paradoxical vocal cord movement in chronic cough', Respirology (TSANZ Abstracts-Posters) (2007) [E3]
2007 See H, Oldham R, Timmins N, Hansbro PM, Wark PA, Gibson PG, 'Rhinovirus (RV) induced inflammatory response in mononuclear cells is enhanced by coculture with airway epithelium', Respirology (TSANZ Abstracts-Posters) (2007) [E3]
DOI 10.1111/j.1440-1843.2007.001050.x
Co-authors Peter Wark, Philip Hansbro
2007 Wark PA, Mimica J, Oldham R, Davies DE, Holgate SE, Johnston S, Gibson PG, 'Interferon-G induced protein (IP)- 10 is a novel clinical biomarker of rhinovirus (RV)-induced asthma exacerbations', Respirology (TSANZ Abstracts-Posters) (2007) [E3]
Co-authors Peter Wark
2007 Wood LG, Garg ML, Powell H, Gibson PG, 'Dietary lycopene reduces neutrophilic airway inflammation in asthma', Respirology (TSANZ Abstracts-Posters) (2007) [E3]
Co-authors Manohar Garg, Lisa Wood
2007 Simpson JL, Hansbro PM, Kenyon ME, Gibson PG, 'Remodelled asthma in the elderly: is asthma turning into COPD?', Respirology (TSANZ Abstracts-Posters) (2007) [E3]
Co-authors Philip Hansbro, Jodie Simpson
2007 Simpson JL, Milne DG, Gibson PG, 'Radiographic differences between neutrophilic asthma, COPD and smokers using HRCT', Respirology (TSANZ Abstracts-Posters) (2007) [E3]
Co-authors Jodie Simpson
2007 Simpson JL, Powell H, Boyle MJ, Scott R, Gibson PG, 'Anti-inflammatory effects of clarithromycin in refractory non-eosinophilic asthma', Respirology (TSANZ Abstracts-Posters) (2007) [E3]
DOI 10.1111/j.1440-1843.2007.001050.x
Co-authors Rodney Scott, Jodie Simpson
2007 Timmins NL, Wood LG, Simpson JL, Gibson PG, 'Optimising exhaled breath condensate collection', Respirology (TSANZ Abstracts-Posters) (2007) [E3]
Co-authors Jodie Simpson, Lisa Wood
2007 Jenkins CR, Marks GB, Gibson PG, Wark PA, Thien FCK, Belousova EG, et al., 'A randomised controlled trial of two algorithms for maintaining asthma control on long acting bronchodilators (LABA) and inhaled corticosteroids (ICS)', Respirology (TSANZ Abstracts-Posters) (2007) [E3]
Co-authors Peter Wark
2006 Horvat JC, Preston JA, Gibson PG, Beagley KW, Foster PS, Hansbro PM, 'Exacerbation of Allergic Airways Disease (AAD) by Chlamydia is Differentially Affected by the Timing of Infection Relative to Allergen Exposure', Immunology and Cell Biology (2006) [E3]
Co-authors Jay Horvat, Paul Foster, Philip Hansbro
2006 Preston JA, Horvat JC, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'Streptococcus pneumoniae (SPN) lung infection suppresses hallmark features of a mouse model of asthma', Immunology and Cell Biology (2006) [E3]
Co-authors Jay Horvat, Philip Hansbro, Paul Foster
2006 Horvat JC, Moller CG, Wade MA, Preston JA, Hansbro NG, Gibson PG, et al., 'The development of allergic airways disease (AAD) is differently affected by chlamydial lung infection at different stages of life', Immunology and Cell Biology (2006) [E3]
Co-authors Jay Horvat, Philip Hansbro, Nicole Hansbro, Paul Foster
2006 Wood LG, Garg ML, Gibson PG, 'Asthma control deteriorates on a low antioxidant diet', European Respiratory Journal Supplement (2006) [E3]
Co-authors Manohar Garg, Lisa Wood
2006 Wood LG, Garg ML, Powell HG, Gibson PG, 'Dietary lycopene and asthma control: A randomized control trial', Asia Pacific Journal of Clinical Nutrition (2006) [E3]
Co-authors Manohar Garg, Lisa Wood
2006 Saedisomeolia A, Garg ML, Wood LG, Gibson PG, 'Lycopene supplementation does not influence cytokine profile in asthma patients', Asia Pacific Journal of Clinical Nutrition (2006) [E3]
Co-authors Manohar Garg, Lisa Wood
2006 Simpson JL, Scott R, Boyle MJ, Oldham RA, Gibson PG, 'IL-8 levels ininflammatory subtypes of airway disease', Respirology (2006) [E3]
Co-authors Rodney Scott, Jodie Simpson
2006 Grissell TV, Davies B, Mimica JL, Shafren DR, Gibson PG, Wark PA, 'Bronchial epithelial cell response to clinical rhinoviruses isolated from asthmatics compared to laboratory rhinovirus strains', Respirology (2006) [E3]
Co-authors Peter Wark
2006 Mattes J, Simpson JL, Foster PS, Gibson PG, 'Trail is upregulated in the airways of asthmatics', Respirology (2006) [E3]
Co-authors Paul Foster, Joerg Mattes, Jodie Simpson
2006 Wark PA, Wood LG, Grissell TV, Davies B, Shafren DR, Powell HG, et al., 'Acute virus-induced asthma is characterised by increased expression of toll-like receptors (TLR)-2', Respirology (2006) [E3]
Co-authors Michael Hensley, Peter Wark, Lisa Wood
2006 Marchant JM, Gibson PG, Timmins NL, Taylor SM, Masters IB, Chang AB, 'Protracted Bacterial Bronchitis in Children - a celluar and inflammatory profile', Respirology (2006) [E3]
2006 Horvat JC, Wade MA, Preston JA, Hansbro NG, Gibson PG, Beagley KW, et al., 'Early life chlamydial lung infection enhances allergic airways disease (AAD)', Respirology (2006) [E3]
Co-authors Philip Hansbro, Nicole Hansbro, Paul Foster, Jay Horvat
2006 Preston JA, Horvat JC, Wade MA, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'Inhibition of allergic lung disease by respiratory streptococcus pneumoniae infection', Respirology (2006) [E3]
Co-authors Jay Horvat, Paul Foster, Philip Hansbro
2006 Aggarwal S, Grissell TV, Timmins N, Gibson PG, Thompson P, Misso N, '5-Lipoxygenase pathway MRNA expression in sputum cells of patients with Eosinophilic or Non-Eosinophilic Asthma', Respirology (2006) [E3]
2006 Simpson JL, Scott R, Boyle MJ, Gibson PG, 'Inflammatory subtypes in asthma with fixed airflow obstruction', Respirology (2006) [E3]
Co-authors Rodney Scott, Jodie Simpson
2006 Baines KJ, Simpson JL, Scott R, Bell NV, Boyle MJ, Gibson PG, 'Enhanced IL-8 release from neutrophils in non-eosinophilic asthma', Respirology (2006) [E3]
Co-authors Jodie Simpson, Rodney Scott, Katherine Baines
2006 Wood LG, Garg ML, Gibson PG, 'A low antioxidant diet worsens asthma control', Respirology (2006) [E3]
Co-authors Lisa Wood, Manohar Garg
2006 Vincent S, Jenkins C, Gibson PG, Helen R, 'Efficacy of B2- Agonist in asthma exacerbations', Respirology (2006) [E3]
2006 Wlodarczyk JH, Gibson PG, Caeser M, 'Quantitative review: Inhaled corticosteroids and cortisol suppression in airways disease', Respirology (2006) [E3]
2006 Heather P, Gibson PG, 'Efficacy and safety of long-acting beta-agonist and inhaled corticosteroid therapy for adults with asthma: a meta -view', Respirology (2006) [E3]
2006 Ryan (Ext) NM, Gibson PG, 'Cough reflex hypersensitivity and upper airway hyperresponsiveness in vocal cord dysfunction with chronic cough', Respirology (2006) [E3]
2006 Vertigan (Ext) A, Theodoros D, Gibson PG, Winkworth A, 'Efficacy of speech pathology treatment for refractory chronic cough', Respirology (2006) [E3]
2006 Wood LG, Garg ML, Powell H, Gibson PG, 'Modifying Dietary Antioxidant Consumption Affects Clinical Status and Noneosinophilic Airway Inflammation in Asthma', Respirology (2006) [E3]
Co-authors Manohar Garg, Lisa Wood
2006 Simpson JL, Grissell TV, Douwes J, Scott R, Boyle MJ, Gibson PG, 'Innate immune activation in neutrophilic asthma', The Journal of the Japanese Respiratory Society (2006) [E3]
Co-authors Jodie Simpson, Rodney Scott
2006 Horvat JC, Wade MA, Preston JA, Hansbro NG, Gibson PG, Beagley KW, et al., 'Neonatal chlamydial infection exacerbates allergic airways disease', Abstracts ATS 2006 International Conference (2006) [E3]
Co-authors Philip Hansbro, Nicole Hansbro, Paul Foster, Jay Horvat
2006 Preston JA, Horvat JC, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'Respiratory Streptococcus pneumoniae infection decreases key inflammatory responses in a mouse model of asthma', Abstracts ATS 2006 International Conference (2006) [E3]
Co-authors Philip Hansbro, Paul Foster, Jay Horvat
2006 Simpson JL, Scott R, Boyle MJ, Gibson PG, 'Inflammatory subtypes in Asthma with fixed airflow obstruction', American Thoracic Society. Proceedings (2006) [E3]
Co-authors Jodie Simpson, Rodney Scott
2006 Gadil E, Morris PS, Beissbarth J, Chang A, Gibson PG, Hare K, et al., 'Use of ototopical antibiotic treatment on chronic suppurative otitis media: A randomized placebo controlled trial and feasibility study', 5th International Symposim on Pneumoccoci and Pneumococcal Diseases (2006) [E3]
Co-authors Philip Hansbro
2006 Preston JA, Horvat JC, Wade MA, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'Inhibition of allergic lung disease by respiratory Streptococcus pneumoniae infection', 5th International Symposium on Pneumococci and Pneumococcal Diseases (2006) [E3]
Co-authors Jay Horvat, Paul Foster, Philip Hansbro
2006 Preston JA, Horvat JC, Wade MA, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'The influence of allergic airways disease on the immune response to respiratory Streptococcus pneumoniae infection', 5th International Symposium on Pneumococci and Pneumococcal Diseases (2006) [E3]
Co-authors Paul Foster, Jay Horvat, Philip Hansbro
2005 Murphy VE, Clifton VL, Talbot PI, Gibson PG, 'Severe asthma exacerbations during pregnancy', Perinatal Society of Australia and New Zealand 9th Annual Congress, Adelaide, 13-16 March, 2005 (2005) [E3]
Citations Scopus - 112Web of Science - 86
Co-authors Vicki Clifton, Vanessa Murphy
2005 Preston JA, Horvat JC, Wade MA, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'Respiratory streptococcus pneumoniae infection decreases key inflammatory responses in a mouse model of asthma', TISSUE ANTIGENS (2005)
Co-authors Philip Hansbro, Paul Foster, Jay Horvat
2005 Horvat JC, Wade MA, Preston JA, Newcombe N, Ferguson AL, Kaiko G, et al., 'Neonatal But Not Adult Chlamydial Infection Induces the Development of Allergic Airways Disease Through Novel Mechanisms Involving Inflammation of Mixed Phenotype', Tissue Antigens (2005) [E3]
Citations Web of Science - 1
Co-authors Jay Horvat, Philip Hansbro, Paul Foster
2005 Murphy VE, Clifton VL, Gibson PG, 'Asthma exacerbations during pregnancy are associated with low birth weight', European Respiratory Journal (2005) [C3]
Co-authors Vicki Clifton, Vanessa Murphy
2005 Wood LG, Garg ML, Blake RJ, Simpson JL, Gibson PG, 'Systemic and airway levels of glutathione and alpha-tocopherol in asthma', Asia Pacific Journal of Clinical Nutrition (2005) [E3]
Co-authors Manohar Garg, Jodie Simpson, Lisa Wood
2005 Simpson JL, Gibson PG, 'Deficient Sputum Anti-Protease Defenses in Neutrophilic and Eosinophilic Asthma', INFLAMMATION RESEARCH (2005)
Co-authors Jodie Simpson
2005 Bains KJ, Bell NV, Simpson JL, Scott RJ, Boyle MJ, Gibson PG, 'Enhanced IL-8 Release front Neutrophils in Non-Eosinophilic Asthma', INFLAMMATION RESEARCH (2005)
Co-authors Rodney Scott, Jodie Simpson
2005 Horvat JC, Preston JA, Hansbro NG, Ferguson AL, Gibson PG, Beagley KW, et al., 'Neonatal chlamydial infection inhibits the development of allergic airway inflammation in adult mice', Inflammation Research (2005) [E3]
Co-authors Nicole Hansbro, Paul Foster, Jay Horvat, Philip Hansbro
2005 Murphy VE, Talbot PI, Clifton VL, Gibson PG, 'Severe asthma exacerbations during pregnancy', American Journal of Respiratory and Critical Care (2005) [C3]
Co-authors Vicki Clifton, Vanessa Murphy
2005 Murphy VE, Clifton VL, Talbot PI, Gibson PG, 'Self-management education for pregnant women with asthma', American Journal of Respiratory and Critical Care Medicine (2005) [C3]
Co-authors Vanessa Murphy, Vicki Clifton
2005 Gibson PG, Giles WB, Zakar T, Smith R, Kessell CG, Clifton VL, Murphy VE, 'Inflammatory factors have sex-specified effects on fetal growth in humans', Ceska Gynekologie (2005) [C3]
Co-authors Roger Smith, Vanessa Murphy, Vicki Clifton
2005 Preston JA, Horvat JC, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'Timing of Streptococcus Pneumoniae (pnc) infection determines the magnitute of the effect on allergic airways inflammation (AAI) in a mouse model of asthma', Respirology (2005) [E3]
Co-authors Philip Hansbro, Paul Foster, Jay Horvat
2005 Preston JA, Horvat JC, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'Respiratory Streptococcus Pneumoniae Infection Decreases Eosinophilia and Mucus Cell Hyperplasia in a Mouse Model of Asthma', Respirology (2005) [E3]
Co-authors Jay Horvat, Paul Foster, Philip Hansbro
2005 Murphy VE, Talbot PI, Clifton VL, Gibson PG, 'Severe asthma exacerbations during pregnancy', Respirology (2005) [C3]
DOI 10.1097/01.AOG.0000185281.21716.02
Co-authors Vanessa Murphy, Vicki Clifton
2005 Murphy VE, Clifton VL, Talbot PI, Gibson PG, 'Self-management education for pregnant women with asthma. Thoracic Society of Australia and New Zealand Annual Scientific Meeting, Perth, 18-23 March, 2005', Respirology (2005) [C3]
Co-authors Vanessa Murphy, Vicki Clifton
2005 Murphy VE, Talbot PI, Gibson PG, 'The prevalence and cycle to cycle variability of premenstrual asthma', Respirology (2005) [C1]
DOI 10.1111/j.1440-1843.2005.00663.x-i1
Co-authors Vanessa Murphy
2005 Clifton VL, Murphy VE, Gibson PG, Smith R, Giles WB, Scott N, 'Gender specific differences in response to changes in glucocorticoid concentration in the human fetus: Relationship to birthweight', PEDIATRIC RESEARCH (2005)
Co-authors Roger Smith, Vanessa Murphy
2004 Clifton VL, Murphy VE, Osei-Kumah A, Giles WB, Smith R, Gibson PG, 'Gender specific mechanisms of human fetal cortisol metabolism and immunity.', JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION (2004)
Co-authors Vanessa Murphy, Roger Smith
2004 Gibson PG, Murphy VE, Kessell CG, Talbot PI, Giles WB, Smith R, Clifton VL, 'Effect of fetal gender on maternal athsma during pregnancy', American Journal of Respiratory Care (2004) [C3]
Co-authors Vicki Clifton, Vanessa Murphy, Roger Smith
2004 Talbot PI, Murphy VE, Kessell CG, Giles WB, Smith R, Gibson PG, Clifton VL, 'Effect of fetal gender on maternal asthma during pregnancy', Respirology (2004) [C3]
Co-authors Vicki Clifton, Vanessa Murphy, Roger Smith
2004 Murphy VE, Kessell CG, Talbot PI, Gibson PG, Clifton VL, 'Asthma education, lung function and inflammation in pregnant women: relation to birth weight', 8th Annual Conference of the Perinatal Society of Australia and New Zealand, Sydney, 15-19 March, 2004 (2004) [E3]
Co-authors Vanessa Murphy, Vicki Clifton
2004 Clifton VL, Murphy VE, Gibson PG, 'Gender specific growth mechanisms in the human fetus', 8th Annual Conference of the Perinatal Society of Australia and New Zealand, Sydney, 15-19 March, 2004 (2004) [E3]
Co-authors Vicki Clifton, Vanessa Murphy
2004 Wood LG, Garg ML, Blake RJ, Gibson PG, 'Carotenoid concentrations in asthmatics versus healthy controls', Asia Pacific Journal of Clinical Nutrition (2004) [E3]
Co-authors Manohar Garg
2004 Murphy VE, Gibson PG, Kessell CG, Clifton VL, 'Asthma self-management education for pregnant women delivered in an antenatal clinic setting', Perinatal Scoiety of Australian and New Zealand 9th annual Congress, Adelaide, 13-16 March (2004) [E3]
Co-authors Vicki Clifton, Vanessa Murphy
2003 Murphy VE, Gibson PG, Giles WB, Smith R, Clifton VL, 'A novel model for examining fetal growth restriction in human pregnancy', Reproductive Sciences (2003) [C3]
Co-authors Vanessa Murphy, Roger Smith, Vicki Clifton
2003 Murphy VE, Johnson RF, Wang Y, Akinsanya K, Gibson PG, Smith R, Clifton VL, 'A proteomic analysis of maternal plasma, umbilical cord plasma and placenta in asthmatic and non-asthmatic pregnancies', Australian Society for Medical Research, National Scientific Conference, Glenelg, 22-24 Nov, 2003 (2003) [E3]
Co-authors Vanessa Murphy, Roger Smith, Vicki Clifton
2003 Murphy VE, Gibson PG, Giles WB, Smith R, Clifton VL, 'The effect of fetal gender on maternal inflammation and lung function in asthmatic pregnancies', Endocrine Society of Australia Annual Meeting, Melbourne 14-17 Sept, 2003 (2003) [E3]
Co-authors Vicki Clifton, Roger Smith, Vanessa Murphy
2003 Gibson PG, 'Evidence-based medicine at the bedside', PROCEEDINGS OF THE 8TH CONGRESS OF THE ASIAN PACIFIC SOCIETY OF RESPIROLOGY (2003)
2003 Murphy VE, Gibson PG, Giles WB, Smith R, Zarzycki PK, 'Placental and maternal inflammatory pathways in pregnancies complicated by asthma', Placenta (2003) [C3]
Co-authors Vanessa Murphy, Roger Smith
2002 Murphy VE, Gibson PG, Giles WB, Zakar T, Smith R, Kessell CG, Clifton VL, 'Sex-specific changes in placental function and fetal growth and development in pregnancies complicated by ashtma', Endocrine Society of Australia Annual Scientific Meeting, Adelaide, 22-25 Sept, 2002 (2002) [E3]
Co-authors Vicki Clifton, Roger Smith, Vanessa Murphy
2001 Wark P, Simpson JL, Saltos N, Hensley MJ, Gibson PC, 'Itraconazole reduces eosinophilic airway inflammation in allergic bronchopulmonary aspergillosis (abpa)', Respirology (2001)

ABPA is an important complication of chronic asthma resulting from hypersensitivity to the fungus Aspergillus Fumigatus ( AF}. ABPA is characterised by an intense immune response ... [more]

ABPA is an important complication of chronic asthma resulting from hypersensitivity to the fungus Aspergillus Fumigatus ( AF}. ABPA is characterised by an intense immune response with increased use of oral steroids and potentially progressive lung disease. The aim of this study was to determine if treatment of subjects with ABPA with the antifungal agent Itraconazole (Itz) reduced airway and systemic inflammation. Methods: A randomised double blind placebo controlled trial was performed in stable subjects with ABPA (n=29). Subjects with cystic fibrosis ere excluded. The diagnosis of ABPA was based upon; the presence of asthma, IgE sensitisation to Af. a total serum IgE of lOOOIl'/mL or greater and serum IgG to Af or central bronchiectasis on CT scan. Subjects received Itz 400mg per day (n=15) or placebo (n=14) for 16 weeks. All subjects were reviewed monthly with history, spirometry. sputum induction to measure airway inflammation, serum total IgE and IgG to Af and blood eosinophils. Results: Subjects receiving Itz had a greater reduction in sputum eosinophils from baseline (median fall of 94.5%) compared to placebo (45.4%. p<0.01 ). Those on Itz had a fall in sputum total cell count from baseline (43.9%) compared to a rise in those on placebo (rise 10%. p=0.049). Subjects that received Itz also had a reduction in systemic immune activation; there was a fall in serum IgE (3IOIU/mL) compared to placebo (rise ISIU-'mL, p<0.01) and a fall in IgG to Af(15.4IU/mL) compared to placebo (rise 3.7IU-mL, p=0.03). Conclusion: Treatment of subjects with stable ABPA with Itz 400mg daily reduces eosinophilic airway inflammation along with measures of systemic immune activation. These results imply that Itz is a potential adjunctive treatment for ABPA and this should be further investigated with larger studies of lone term clinical efficacv.

Co-authors Michael Hensley, Jodie Simpson, Peter Wark
2001 McDonald VM, Cookson K, Dymond L, Kesseil C, Pratt P, Gibson PG, 'Inhaler polvpharmacy use among patients with asthma', Respirology (2001)

Many patients with asthma use two or more drag classes. Poor inhalation technique limits drag efficacy. There has been an increase in the number and type of drug delivery systems ... [more]

Many patients with asthma use two or more drag classes. Poor inhalation technique limits drag efficacy. There has been an increase in the number and type of drug delivery systems available. This may accentuate the problems with poor inhalation technique and negate the advantage of drag delivery by inhalation. AIMS: The aims of this study are to describe the number of different devices used by patients with asthma, the adequacy of inhalation technique for each device and the effect of a structured education programme on technique and device selection. DESIGN: A cross sectional analytic survey. METHODS: Data was collected from patients attending the Asthma Management Service (AMS) between 1/1/00 and 30/9/00. Inhaler technique was assessed by an asthma educator and rated as adequate or inadequate. The number of devices used by each patient was analysed together with their proficiency of use. RESULTS: 123 patients were referred to the AMS and 112 (91%) attended an initial assessment. 54% were female and 25% were smokers. The age range was 17-79 years. 56% were on doses of ICS greater than 800mcgs/day. 74% of patients were using multiple devices. The patients were using an average of 1.9 different inhalation devices. Inadequate inhaler technique was present in 23% of pMDI users, 6% of spacer users, 29% of turbuhaler users, and 0% of Accuhaler users. Of those using multiple devices 26% were rated as inadequate with at least one of their devices. CONCLUSION: Inhaler polypharmacy exists as a unique problem among people with airways disease, and could lead to limited drag efficacy in a significant proportion of patients. There is a role for asthma education in the identification and management of this problem. :.

Co-authors Vanessa Mcdonald
2001 Kessell C, McDonald V, Pratt P, Cookson K, Wild K, Clifton V, Gibson PG, 'Evaluation of an asthma education programme delivered in an antenatal clinic', Respirology (2001)

Severe and poorly controlled asthma may lead to adverse outcomes for mothers and their babies. An asthma management and education programme was established in the Antenatal Clinic... [more]

Severe and poorly controlled asthma may lead to adverse outcomes for mothers and their babies. An asthma management and education programme was established in the Antenatal Clinic (ANC) of John Hunter Hospital to optimise asthma management in pregnant women with asthma. Aim: The aim of this study was to evaluate the effect of the Asthma Management Service in the John Hunter Hospital ANC. Design: Longitudinal analytic survey. Method: Women were enrolled in their first trimester and underwent an initial assessment of asthma severity, treatment and management skills. Deficits were corrected by skills education, medical assessment and treatment. Records were reviewed of pregnant women with asthma who attended the Asthma Management Service between January 1998 and December 1999. Results: 83 women were enrolled and 72 patients attended between 2 and 8 visits during pregnancy, depending upon asthma severity. Conclusion: After structured asthma education, there were significant improvements in asthma knowledge and management skills. The antenatal clinic is a opportune setting for asthma education among pregnant women with asthma. Asthma Control Visit 1 After Education p Value Night Symptoms 53% 42% 0.15 Morning Symptoms 66% 46% 0.01 Activity Limitation 35% 30% 0.65 Asthma Skills pMDI: Inadequate 13% 0% 0.001 Spacer: Inadequate 2% 0% 0.50 Medication Knowledge 47% 88% 0.0001 Action Plan 13% 78% 0.0001 Peak Flow Monitoring 8% 78% 0.0001.

Co-authors Vanessa Mcdonald
2001 Murphy VE, Zakar T, Gibson PG, Giles WB, Smith R, Clifton VL, 'Pleacental 11beta-HSD2 activity in asthmatic women', Reproductive sciences (2001) [C3]
Co-authors Roger Smith, Vicki Clifton, Vanessa Murphy
2001 Murphy VE, Zakar T, Smith R, Giles WB, Gibson PG, Clifton VL, 'A potential mechnism for growth retardation in pregnancies complicated by asthma', Endocrine Society of Australia Annual Scientific Meeting, Gold Coast, 9-12 Sept, 2001 (2001) [E3]
Co-authors Roger Smith, Vanessa Murphy, Vicki Clifton
2001 Collins CE, Linabury N, Whitehead BF, Gibson PG, 'Nutritional status & lung function in the adolescent cohort attending John Hunter Hospital CF Clinic', Proceedings of the 4th Australian CF Conference (2001) [E3]
Co-authors Clare Collins
2000 Fitzgerald D, Wood LG, Gibson PG, Cooper D, Garg ML, 'Elevated plasma levels of 8-iso-PGF2a in asthma', American Journal of Respiratory and Critical Care Medicine ISSN 1073-449X (2000) [E3]
Co-authors Lisa Wood, Manohar Garg
2000 Jones PD, Hankin RG, Cai Y, Norzilla M, Henry RL, Gibson PG, Simpson J, 'Tolerability, Safety and Success of Induced Sputum with Hypertonic Saline (HS) and the Combined HS Challenge in Children', Journal of Paediatrics & Child Health (2000) [E3]
2000 Jones PD, Hankin RG, Henry RH, Gibson PG, Simpson J, 'How Chemotherapy Alters the Prevalence of Asthma', Journal of Paediatrics & Child Health (2000) [E3]
1999 Jones PD, Henry RL, Francis L, Gibson PG, 'Chemotherapy reduces the prevalence of asthma symptoms in children with cancer: Implications for the role of airway inflammation in asthma', JOURNAL OF PAEDIATRICS AND CHILD HEALTH (1999)
DOI 10.1046/j.1440-1754.1999.00358.x
Citations Scopus - 1Web of Science - 1
1999 Wood LG, Fitzgerald D, Gibson PG, Cooper D, Collins CE, Garg ML, 'Isoprostanes as a Novel Marker of Oxidative Stress in Cystic Fibrosis', 3rd Australian Cystic Fibrosis Conference (1999) [E3]
Co-authors Lisa Wood, Manohar Garg, Clare Collins
1999 Wood LG, Fitzgerald D, Gibson PG, Cooper D, Collins CE, Garg ML, '8-ISO-PGF2a and Oxidative Stress in Cystic Fibrosis', Weighing the Evidence Programme and Proceedings (1999) [E3]
Co-authors Manohar Garg, Lisa Wood, Clare Collins
1998 Gibson PG, 'Use of induced sputum to examine airway inflammation in childhood asthma', JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (1998)
DOI 10.1016/S0091-6749(98)70039-9
Citations Scopus - 30Web of Science - 22
1998 Wood LG, Fitzgerald D, Cooper D, Gibson PG, Garg ML, 'Antioxidant defenses in cystic fibrosis patients', Proceedings of the Nutrition Society of Australia (1998) [E3]
Co-authors Manohar Garg, Lisa Wood
Show 311 more conferences

Software / Code (2 outputs)

Year Citation Altmetrics Link
1998 Davies HM, Olson LG, Gibson PG, 'Methotrexate as a steroid- sparing agent in adults with asthma', NOT AVAILABLE, Update Software, Oxford (1998) [G1]
1998 Gibson PG, Wilson AJ, Coughlan J, Hensley MJ, Abramson MJ, Bauman A, Walters EH, 'The effects of limited (information only) asthma education on health outcomes of adults with asthma.(In: Cates C, DuCharme F, Gibson P, Jones P, Rowe B, Wolf F, Airays Module Cochrane Database of Systematic Reviews', NOT AVAILABLE, Update Software, Oxford U.K. (1998) [G1]
Co-authors Michael Hensley

Patent (3 outputs)

Year Citation Altmetrics Link
2008 Hansbro PM, Gibson PG, Vaccine compositions (2008) [I3]
Co-authors Philip Hansbro
2007 Gibson PG, Hansbro PM, Treatment and prevention of allergic airways diseases (2007) [I3]
Co-authors Philip Hansbro
2006 Gibson PG, Wood LG, Garg ML, Method for evaluating status of asthma control (2006) [I3]
Co-authors Lisa Wood, Manohar Garg

Creative Work (1 outputs)

Year Citation Altmetrics Link
2011 McDonald VM, Wark PA, Gibson PG, Alison J, Spencer L, Wood LG, Roberts M, Living with COPD: Chronic Obstructive Pulmonary Disease, Newcastle (2011) [J2]
Co-authors Vanessa Mcdonald, Lisa Wood, Peter Wark
Edit

Grants and Funding

Summary

Number of grants 122
Total funding $27,732,482

Click on a grant title below to expand the full details for that specific grant.


20165 grants / $825,239

Targeting neutrophil extracellular traps to reduce inflammation in severe asthma$585,239

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Doctor Katie Baines, Conjoint Professor Peter Gibson, Associate Professor Jodie Simpson, Professor Dominik Hartl, Associate Professor Vanessa McDonald
Scheme Project Grant
Role Investigator
Funding Start 2016
Funding Finish 2018
GNo G1500231
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

The pneumococcal vaccine Prevenar 13 as a new asthma therapy$180,000

Funding body: Asthma Australia

Funding body Asthma Australia
Project Team Conjoint Professor Peter Gibson, Professor Phil Hansbro
Scheme National Research Program
Role Lead
Funding Start 2016
Funding Finish 2018
GNo G1500725
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

The impact of azithromycin therapy on the airway microbiome in severe asthma$20,000

Funding body: National Clinical CRE in Severe Asthma

Funding body National Clinical CRE in Severe Asthma
Project Team Associate Professor Jodie Simpson, Conjoint Professor Peter Gibson
Scheme Seed Research Project
Role Investigator
Funding Start 2016
Funding Finish 2016
GNo G1600441
Type Of Funding Internal
Category INTE
UON Y

Development and Validation of the First Patient Reported Outcome Measure in Severe Asthma (PROMISe)$20,000

Funding body: National Clinical CRE in Severe Asthma

Funding body National Clinical CRE in Severe Asthma
Project Team Associate Professor Vanessa McDonald, Conjoint Professor Peter Gibson, Professor Janelle Yorke
Scheme Seed Research Project
Role Investigator
Funding Start 2016
Funding Finish 2016
GNo G1600921
Type Of Funding Internal
Category INTE
UON Y

Managing Inflammation in COPD (MiCOPD)$20,000

Funding body: Lung Foundation Australia

Funding body Lung Foundation Australia
Project Team Associate Professor Vanessa McDonald, Conjoint Professor Peter Gibson, Associate Professor Jodie Simpson, Conjoint Professor Peter Wark
Scheme Boehringer Ingelheim COPD Research Top-Up Grant
Role Investigator
Funding Start 2016
Funding Finish 2017
GNo G1601013
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

20152 grants / $35,222

Targeting neutrophil extracellular traps as a novel therapeutic option in COPD$25,222

Funding body: John Hunter Hospital Charitable Trust

Funding body John Hunter Hospital Charitable Trust
Project Team Doctor Katie Baines, Conjoint Professor Peter Gibson
Scheme Research Grant
Role Investigator
Funding Start 2015
Funding Finish 2015
GNo G1500570
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

(PROJECT)$10,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Associate Professor Vanessa McDonald, Mrs Netsanet Negewo, Conjoint Professor Peter Gibson, Doctor Katie Baines
Scheme Jennie Thomas Medical Research Travel Grant
Role Investigator
Funding Start 2015
Funding Finish 2015
GNo G1501430
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

201411 grants / $5,239,942

National Clinical Centre of Research Excellence in Severe Asthma$2,542,311

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Peter Gibson, Professor Guy Marks, Associate Professor Vanessa McDonald, Conjoint Associate Professor Greg King, Dr Bruce Thompson, Associate Professor Helen Reddel, Professor John Upham, Dr Lorraine Smith, Professor Alan James
Scheme Centres of Research Excellence (CRE) - Centres of Clinical Research Excellence
Role Lead
Funding Start 2014
Funding Finish 2019
GNo G1400017
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

The Breathing for Life Trial $1,647,904

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Doctor Vanessa Murphy, Conjoint Professor Peter Gibson, Emeritus Professor Michael Hensley, Professor Joerg Mattes, Professor Warwick Giles, Professor Michael Peek, Associate Professor Andrew Bisits, Associate Professor Leonie Callaway, Dr Kirsten McCaffery, Dr Helen Barrett
Scheme Project Grant
Role Investigator
Funding Start 2014
Funding Finish 2018
GNo G1300106
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Airway Inflammometry for Asthma and COPD: Practitioner Fellowship Peter G Gibson$542,215

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Peter Gibson
Scheme Practitioner Fellowships
Role Lead
Funding Start 2014
Funding Finish 2018
GNo G1300083
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Severe Asthma Web-based Database (SAWD) & Research Register$165,000

Funding body: Woolcock Institute of Medical Science

Funding body Woolcock Institute of Medical Science
Project Team Conjoint Professor Peter Gibson, Professor Guy Marks
Scheme Research Grant
Role Lead
Funding Start 2014
Funding Finish 2016
GNo G1400292
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Greenland Study$140,000

Funding body: Bispebjerg Hospital

Funding body Bispebjerg Hospital
Project Team Conjoint Professor Peter Gibson, Doctor Katie Baines, Professor Vibeke Backer
Scheme International Collaboration
Role Lead
Funding Start 2014
Funding Finish 2016
GNo G1400539
Type Of Funding International - Non Competitive
Category 3IFB
UON Y

The Nanostring nCounter System$75,000

Funding body: Ramaciotti Foundations

Funding body Ramaciotti Foundations
Project Team Professor Darryl Knight, Professor Phil Hansbro, Laureate Professor Paul Foster, Professor Rodney Scott, Conjoint Professor Peter Gibson, Professor Michael Nilsson
Scheme Major Equipment Award
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1300853
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

The Nanostring nCounter System$40,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor Darryl Knight, Professor Phil Hansbro, Laureate Professor Paul Foster, Professor Rodney Scott, Conjoint Professor Peter Gibson, Professor Michael Nilsson
Scheme Equipment Grant
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1301083
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Investigating the Phenotypes of Bronchiectasis$27,512

Funding body: John Hunter Hospital Charitable Trust

Funding body John Hunter Hospital Charitable Trust
Project Team Associate Professor Vanessa McDonald, Conjoint Professor Peter Gibson, Mrs Netsanet Negewo
Scheme Research Grant
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1400084
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

The Nanostring nCounter System$20,000

Funding body: John Hunter Hospital Charitable Trust

Funding body John Hunter Hospital Charitable Trust
Project Team Professor Darryl Knight, Professor Phil Hansbro, Laureate Professor Paul Foster, Professor Rodney Scott, Conjoint Professor Peter Gibson, Professor Michael Nilsson
Scheme Research Grant
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1301084
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

The role of comorbidities and inflammation in Chronic Obstructive Pulmonary Disease (COPD)$20,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Mrs Netsanet Negewo, Associate Professor Vanessa McDonald, Conjoint Professor Peter Gibson, Doctor Katie Baines
Scheme Postgraduate Research Scholarship
Role Investigator
Funding Start 2014
Funding Finish 2015
GNo G1401393
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Predicting who is at risk of worsening lung disease in Cystic Fibrosis$20,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Conjoint Professor Peter Wark, Doctor Katie Baines, Associate Professor Vanessa McDonald, Conjoint Professor Peter Gibson, Associate Professor Scott Bell, Dr David Reid
Scheme Project Grant
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1401410
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

201310 grants / $3,040,614

HMRI MRSP Infrastructure (12-16) - VIVA Program$1,633,124

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Laureate Professor Paul Foster, Conjoint Professor Peter Gibson
Scheme NSW MRSP Infrastructure Grant
Role Investigator
Funding Start 2013
Funding Finish 2016
GNo G1300567
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Inflammometry in Stable COPD; A Randomised Controlled Trial (RCT)$717,071

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Peter Gibson, Associate Professor Vanessa McDonald, Associate Professor Jodie Simpson, Conjoint Professor Peter Wark
Scheme Project Grant
Role Lead
Funding Start 2013
Funding Finish 2016
GNo G1200185
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Gene Expression Biomarkers Predict Severe Asthma Inflammatory Phenotype, Activation Mechanisms and Treatment Response$449,307

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Doctor Katie Baines, Conjoint Professor Peter Gibson, Associate Professor Jodie Simpson
Scheme Project Grant
Role Investigator
Funding Start 2013
Funding Finish 2015
GNo G1200188
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Protracted bacterial bronchitis: long term outcomes, systemic and airway predictors of recurrence$76,526

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Anne Chang, Professor John Upham, Conjoint Professor Peter Gibson, Dr Stephanie Yerkovich, Doctor Katie Baines, Dr Sandra Hodge, Mrs Susan Pizzuto, Associate Professor Ian Masters, Dr Helen Buntain
Scheme Project Grant
Role Lead
Funding Start 2013
Funding Finish 2016
GNo G1200534
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Immunometabolism in Obese Asthmatics$73,959

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Conjoint Professor Peter Gibson, Associate Professor Lisa Wood
Scheme Project Grant
Role Lead
Funding Start 2013
Funding Finish 2015
GNo G1300196
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

The Financial Markets Foundation for Children$25,627

Funding body: Financial Markets Foundation for Children

Funding body Financial Markets Foundation for Children
Project Team Conjoint Professor Peter Gibson
Scheme Project Grant
Role Lead
Funding Start 2013
Funding Finish 2014
GNo G1301030
Type Of Funding Aust Competitive - Non Commonwealth
Category 1NS
UON Y

BD FACSCanto II Violet Laser (405nm) upgrade including Trigon and 2 photomultiplier tubes (PMTs)$25,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Peter Wark, Doctor Alan Hsu, Doctor Katie Baines, Associate Professor Jodie Simpson, Conjoint Professor Peter Gibson, Ms Hayley See
Scheme Equipment Grant
Role Investigator
Funding Start 2013
Funding Finish 2013
GNo G1201180
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

Inflammometry-based management of asthma in pregnancy for the prevention of preterm birth: the iMAP study$20,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Doctor Vanessa Murphy, Conjoint Professor Peter Gibson, Emeritus Professor Michael Hensley, Conjoint Professor Warwick Giles, Conjoint Associate Professor Andrew Bisits, Dr Kirsten McCaffery, Professor Paul Colditz, Professor Michael Peek
Scheme Near Miss Grant
Role Investigator
Funding Start 2013
Funding Finish 2013
GNo G1300477
Type Of Funding Internal
Category INTE
UON Y

Effect of better asthma management in pregnancy on antiviral responses, atopy and airways inflammation in early childhood$10,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Joerg Mattes, Conjoint Professor Peter Gibson, Doctor Vanessa Murphy
Scheme Near Miss Grant
Role Investigator
Funding Start 2013
Funding Finish 2013
GNo G1300476
Type Of Funding Internal
Category INTE
UON Y

Effect of better asthma management in pregnancy on antiviral responses, atopy and airways inflammation in early childhood.$10,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor Joerg Mattes, Conjoint Professor Peter Gibson, Doctor Vanessa Murphy
Scheme Near Miss
Role Investigator
Funding Start 2013
Funding Finish 2013
GNo G1300694
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

20129 grants / $1,076,820

HMRI MRSP Infrastructure (11-12)- VIVA$486,671

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Laureate Professor Paul Foster, Conjoint Professor Peter Gibson
Scheme NSW MRSP Infrastructure Grant
Role Investigator
Funding Start 2012
Funding Finish 2012
GNo G1101137
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

BD FACSAria III Cell Sorter: 3 laser 10-colour Flow Cytometer$180,000

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Laureate Professor Paul Foster, Conjoint Professor Peter Gibson, Laureate Professor John Aitken, Laureate Professor Roger Smith, Professor Rodney Scott
Scheme Linkage Infrastructure Equipment & Facilities (LIEF)
Role Investigator
Funding Start 2012
Funding Finish 2012
GNo G1100746
Type Of Funding Scheme excluded from IGS
Category EXCL
UON Y

BD FACSAria III Cell Sorter: 3 laser 10-colour Flow Cytometer$150,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Laureate Professor Paul Foster, Professor Trevor Day, Conjoint Professor Peter Gibson, Laureate Professor John Aitken, Laureate Professor Roger Smith, Professor Rodney Scott
Scheme Equipment Grant
Role Investigator
Funding Start 2012
Funding Finish 2012
GNo G1100744
Type Of Funding Internal
Category INTE
UON Y

BD FACSAria III Cell Sorter: 3 laser 10-colour Flow Cytometer$122,927

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Laureate Professor Paul Foster, Conjoint Professor Peter Gibson, Laureate Professor John Aitken, Laureate Professor Roger Smith, Professor Rodney Scott
Scheme Project Grant
Role Investigator
Funding Start 2012
Funding Finish 2012
GNo G1200668
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Phenotype based management of severe persistent asthma$34,454

Funding body: John Hunter Hospital Charitable Trust

Funding body John Hunter Hospital Charitable Trust
Project Team Associate Professor Vanessa McDonald, Doctor Katie Baines, Conjoint Professor Peter Gibson
Scheme Research Grant
Role Investigator
Funding Start 2012
Funding Finish 2012
GNo G1200211
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Body plethysmograph respiratory function system$33,076

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Peter Gibson, Conjoint Professor Peter Wark, Associate Professor Lisa Wood, Associate Professor Jodie Simpson, Doctor Katie Baines, Doctor Vanessa Murphy, Doctor Jeffrey Pretto, Emeritus Professor Michael Hensley, Ms Jenny Mackney
Scheme Equipment Grant
Role Lead
Funding Start 2012
Funding Finish 2012
GNo G1100973
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

The Growing into Asthma Study: Wheezing prevalence and markers of airways inflammation in preschoolers born to mothers in asthma exacerbations in pregnancy$25,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor Joerg Mattes, Conjoint Professor Peter Gibson, Emeritus Professor Michael Hensley, Conjoint Associate Professor Bruce Whitehead, Doctor Vanessa Murphy
Scheme Project Grant
Role Investigator
Funding Start 2012
Funding Finish 2012
GNo G1200662
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Fatty acids, Carbohydrates and Bronchodilator Responses in Asthma$24,692

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Associate Professor Lisa Wood, Conjoint Professor Peter Gibson
Scheme Project Grant
Role Investigator
Funding Start 2012
Funding Finish 2012
GNo G1200618
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Phenotype based management of severe persistent asthma$20,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Associate Professor Vanessa McDonald, Doctor Katie Baines, Conjoint Professor Peter Gibson
Scheme Research Grant
Role Investigator
Funding Start 2012
Funding Finish 2012
GNo G1101169
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

20116 grants / $670,884

HMRI MRSP Infrastructure Grant (10-11) VIVA$485,452

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Conjoint Professor Peter Gibson, Laureate Professor Paul Foster
Scheme NSW MRSP Infrastructure Grant
Role Lead
Funding Start 2011
Funding Finish 2011
GNo G1100162
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

DVCR Special Grant 2011$80,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Conjoint Professor Peter Gibson
Scheme Special Project Grant
Role Lead
Funding Start 2011
Funding Finish 2011
GNo G1101010
Type Of Funding Internal
Category INTE
UON Y

MAID: Microarray analysis following anti inflammatory interventions in COPD$47,732

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Associate Professor Lisa Wood, Conjoint Professor Peter Gibson
Scheme Centres of Research Excellence (CRE) - Centres of Clinical Research Excellence
Role Investigator
Funding Start 2011
Funding Finish 2011
GNo G1100019
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Transcriptional Phenotyping of COPD and the relationship between neutrophilic airway inflammation, airway infection and activation of proinflammatory pathways$24,000

Funding body: John Hunter Hospital Charitable Trust

Funding body John Hunter Hospital Charitable Trust
Project Team Doctor Katie Baines, Conjoint Professor Peter Gibson, Associate Professor Jodie Simpson
Scheme Research Grant
Role Investigator
Funding Start 2011
Funding Finish 2011
GNo G1100635
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Identification of a specific biomarker signature that identifies asthma phenotype $23,700

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Katie Baines, Associate Professor Jodie Simpson, Conjoint Professor Peter Gibson
Scheme Project Grant
Role Investigator
Funding Start 2011
Funding Finish 2011
GNo G1001054
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Lung Function (Spirometry) testing and sputum induction equipment - establishing 3 new clinical workstations. Medgraphics CPFS/d USB spirometer with breezesuite software (x3). Laptop computer (x3). Ul$10,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Peter Gibson, Associate Professor Jodie Simpson, Associate Professor Lisa Wood, Doctor Katie Baines, Conjoint Professor Peter Wark, Doctor Vanessa Murphy
Scheme Equipment Grant
Role Lead
Funding Start 2011
Funding Finish 2011
GNo G1100038
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

20103 grants / $751,446

HMRI MRSP Infrastructure Grant (09-10) - VIVA$397,696

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Laureate Professor Paul Foster, Conjoint Professor Peter Gibson
Scheme NSW MRSP Infrastructure Grant
Role Investigator
Funding Start 2010
Funding Finish 2010
GNo G1000232
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Gabapentin in the treatment of idiopathic chronic cough: a randomised double-blind placebo-controlled trial$319,750

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Peter Gibson
Scheme Project Grant
Role Lead
Funding Start 2010
Funding Finish 2012
GNo G0190193
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Real time PCR machine (Mastercycler ep realplex2 from Epprndorf) $34,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Associate Professor Jodie Simpson, Conjoint Professor Peter Gibson, Conjoint Professor Peter Wark, Associate Professor Lisa Wood, Doctor Vanessa Murphy, Doctor Robert Scott, Doctor Katie Baines
Scheme Equipment Grant
Role Investigator
Funding Start 2010
Funding Finish 2010
GNo G1000056
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

200910 grants / $4,065,779

The AMAZES study: asthma and macrolides: the AZithromycin efficacy and safety study$2,991,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Peter Gibson, Associate Professor Jodie Simpson, Professor John Upham, Associate Professor Paul Reynolds, Dr Ian Yang, Dr Sandra Hodge
Scheme Project Grant
Role Lead
Funding Start 2009
Funding Finish 2013
GNo G0188843
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Practitioner Fellowship (re-appointment)$360,625

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Peter Gibson
Scheme Practitioner Fellowships
Role Lead
Funding Start 2009
Funding Finish 2013
GNo G0188586
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Epigenetic regulation of airways inflammation in non-eosinophilic asthma$63,354

Funding body: Asthma Foundation of New South Wales

Funding body Asthma Foundation of New South Wales
Project Team Conjoint Professor Peter Gibson, Doctor Katie Baines, Associate Professor Jodie Simpson
Scheme PhD Scholarships
Role Lead
Funding Start 2009
Funding Finish 2011
GNo G0189748
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

394591 ELx405UV select plate washer and workstation integration kit$27,500

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Peter Gibson, Doctor Xiao Yan He, Associate Professor Jodie Simpson, Associate Professor Lisa Wood, Conjoint Professor Peter Wark
Scheme Equipment Grant
Role Lead
Funding Start 2009
Funding Finish 2009
GNo G0189853
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

Growing into asthma: A birth cohort study to investigate the prenatal and development origins of asthma$24,800

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Vanessa Murphy, Professor Joerg Mattes, Conjoint Professor Peter Gibson
Scheme Project Grant
Role Investigator
Funding Start 2009
Funding Finish 2009
GNo G0189802
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

The role of Gabapentin in the treatment of refractory chronic dry cough: A randomised double-blind placebo-controlled study$20,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Conjoint Professor Peter Gibson
Scheme Research Higher Degree Support Grant
Role Lead
Funding Start 2009
Funding Finish 2009
GNo G0189804
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Integrated problem based management of Obstructive Airways Disease in older people$20,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Conjoint Professor Peter Gibson, Professor Isabel Higgins
Scheme Research Higher Degree Support Grant
Role Lead
Funding Start 2009
Funding Finish 2009
GNo G0189807
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Growing into asthma: a birth cohort study to investigate the prenatal and development origins of asthma$13,500

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Vanessa Murphy, Professor Joerg Mattes, Conjoint Professor Peter Gibson
Scheme Project Grant
Role Investigator
Funding Start 2009
Funding Finish 2009
GNo G0190487
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

20087 grants / $318,785

Exploring the link between obesity and asthma$75,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Associate Professor Lisa Wood, Conjoint Professor Peter Gibson, Professor Manohar Garg
Scheme Post Graduate Support Grant
Role Investigator
Funding Start 2008
Funding Finish 2010
GNo G0188479
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Exploring the link between asthma and obesity$66,771

Funding body: CCRE in Respiratory and Sleep Medicine

Funding body CCRE in Respiratory and Sleep Medicine
Project Team Associate Professor Lisa Wood, Conjoint Professor Peter Gibson, Professor Manohar Garg, Ms Hayley Scott
Scheme Postgraduate Research Scholarship
Role Investigator
Funding Start 2008
Funding Finish 2010
GNo G0188635
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Evaluation of self managed and remote delivery of speech pathology treatment for chronic cough$65,000

Funding body: CCRE in Respiratory and Sleep Medicine

Funding body CCRE in Respiratory and Sleep Medicine
Project Team Doctor Anne Vertigan, Conjoint Professor Peter Gibson
Scheme Postdoctoral Research Fellowship
Role Investigator
Funding Start 2008
Funding Finish 2009
GNo G0189582
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

Neurogenic Inflammation and vocal cord dysfunction in chronic cough$42,014

Funding body: CCRE in Respiratory and Sleep Medicine

Funding body CCRE in Respiratory and Sleep Medicine
Project Team Conjoint Professor Peter Gibson, Mrs Nicole Ryan
Scheme Postgraduate Research Scholarship
Role Lead
Funding Start 2008
Funding Finish 2009
GNo G0189060
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Becton Dickinson high throughout sampler for the FACSCanto II cytometry system$35,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Peter Wark, Conjoint Professor Peter Gibson, Associate Professor Jodie Simpson, Associate Professor Lisa Wood, Doctor Vanessa Murphy, Professor Phil Hansbro
Scheme Equipment Grant
Role Investigator
Funding Start 2008
Funding Finish 2008
GNo G0188547
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

Trans Fatty acids and airway inflammation$25,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Associate Professor Lisa Wood, Conjoint Professor Peter Gibson, Professor Manohar Garg
Scheme Project Grant
Role Investigator
Funding Start 2008
Funding Finish 2008
GNo G0188472
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Understanding non-eosinophilic asthma: triggers and treatment$10,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Associate Professor Jodie Simpson, Conjoint Professor Peter Gibson
Scheme Project Grant
Role Investigator
Funding Start 2008
Funding Finish 2008
GNo G0188559
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

200711 grants / $2,235,130

Managing asthma in pregnancy: the MAP study$805,875

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Peter Gibson, Conjoint Associate Professor Vicki Clifton, Emeritus Professor Michael Hensley, Conjoint Professor Warwick Giles
Scheme Project Grant
Role Lead
Funding Start 2007
Funding Finish 2010
GNo G0186407
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

HMRI - Viruses, Infection/Immunity, Vaccines and Asthma Research Program$692,213

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Laureate Professor Paul Foster, Conjoint Professor Peter Gibson, Conjoint Professor Stephen Graves, Associate Professor Darren Shafren
Scheme NSW MRSP Infrastructure Grant
Role Investigator
Funding Start 2007
Funding Finish 2009
GNo G0187930
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Characterisation and Treatment of Innate Immune Dysfunction in Older People with Obstructive Airway Disease$416,875

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Associate Professor Jodie Simpson, Conjoint Professor Peter Gibson, Professor Phil Hansbro
Scheme Project Grant
Role Investigator
Funding Start 2007
Funding Finish 2009
GNo G0186426
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

A Problem Based Approach to the Management of Airways Disease in people over the age of 55 years$88,595

Funding body: CCRE in Respiratory and Sleep Medicine

Funding body CCRE in Respiratory and Sleep Medicine
Project Team Conjoint Professor Peter Gibson, Professor Isabel Higgins
Scheme Postgraduate Research Scholarship
Role Lead
Funding Start 2007
Funding Finish 2010
GNo G0186902
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Differential regulation of human mast cell degranulation by discrete forms of protein phosphatase 2A$50,000

Funding body: Asthma Foundation of New South Wales

Funding body Asthma Foundation of New South Wales
Project Team Professor Alistair Sim, Doctor Nikki Verrills, Laureate Professor Paul Foster, Conjoint Professor Peter Wark, Conjoint Professor Peter Gibson, Dr Gregory Kranias
Scheme Research Grant
Role Investigator
Funding Start 2007
Funding Finish 2007
GNo G0187247
Type Of Funding Donation - Aust Non Government
Category 3AFD
UON Y

Role of p38 MAPK in regulating sex specific placental glucocorticoid receptor function in pregnancies complicated by asthma$50,000

Funding body: Asthma Foundation of New South Wales

Funding body Asthma Foundation of New South Wales
Project Team Conjoint Associate Professor Vicki Clifton, Conjoint Professor Peter Gibson, Conjoint Professor Warwick Giles
Scheme Research Grant
Role Investigator
Funding Start 2007
Funding Finish 2007
GNo G0187258
Type Of Funding Donation - Aust Non Government
Category 3AFD
UON Y

Nitric Oxide Monitoring System (NIOX)$45,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Peter Gibson, Conjoint Associate Professor Vicki Clifton, Conjoint Professor Warwick Giles, Emeritus Professor Michael Hensley, Doctor Vanessa Murphy, Conjoint Professor Peter Wark, Associate Professor Vanessa McDonald, Associate Professor Jodie Simpson, Conjoint Associate Professor Bruce Whitehead, Laureate Professor Paul Foster, Professor Phil Hansbro, Associate Professor Lisa Wood
Scheme Equipment Grant
Role Lead
Funding Start 2007
Funding Finish 2007
GNo G0188193
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

(59) PRC - Priority Research Centre for Asthma & Respiratory Diseases$26,572

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Conjoint Professor Peter Gibson
Scheme Publication Performance Grant
Role Lead
Funding Start 2007
Funding Finish 2008
GNo G0187975
Type Of Funding Internal
Category INTE
UON Y

The effects of passive smoking on children with Asthma$20,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Conjoint Professor Peter Gibson, Conjoint Associate Professor Bruce Whitehead, Emeritus Professor Michael Hensley
Scheme Project Grant
Role Lead
Funding Start 2007
Funding Finish 2007
GNo G0187259
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Hewlett Packard 7890 series gas chromatograph with accessories$20,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Associate Professor Lisa Wood, Conjoint Professor Peter Wark, Conjoint Professor Peter Gibson, Associate Professor Jodie Simpson, Doctor Vanessa Murphy, Laureate Professor Paul Foster, Professor Phil Hansbro, Conjoint Associate Professor Vicki Clifton, Professor Clare Collins, Conjoint Professor Wayne Smith, Professor John Attia
Scheme Equipment Grant
Role Investigator
Funding Start 2007
Funding Finish 2007
GNo G0188191
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

Class II biohazard containment hood and carbon dioxide cell culture incubator$20,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Peter Wark, Conjoint Professor Peter Gibson, Associate Professor Jodie Simpson, Doctor Vanessa Murphy, Associate Professor Lisa Wood, Laureate Professor Paul Foster, Professor Phil Hansbro
Scheme Equipment Grant
Role Investigator
Funding Start 2007
Funding Finish 2007
GNo G0188192
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

20067 grants / $2,105,369

Advanced technology for transcriptomics, genomics and gene mapping$850,000

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Professor Rodney Scott, Professor Ian Dawes, Professor Ronald Trent, Professor Nicholas Hunt, Emeritus Professor Peter Bergquist, Professor Mark Baker, Emeritus Professor Peter Dunkley, Dr Ruby Lin, Conjoint Professor Peter Gibson, Professor Alistair Sim
Scheme Linkage Infrastructure Equipment & Facilities (LIEF)
Role Investigator
Funding Start 2006
Funding Finish 2006
GNo G0185547
Type Of Funding Scheme excluded from IGS
Category EXCL
UON Y

PRC Priority Research Centre for Asthma & Respiratory Diseases$524,282

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Laureate Professor Paul Foster, Conjoint Professor Peter Gibson, Conjoint Professor Kenneth Beagley, Emeritus Professor Michael Hensley, Professor Phil Hansbro, Professor Joerg Mattes, Professor Alistair Sim, Conjoint Professor Peter Wark
Scheme Priority Research Centre
Role Investigator
Funding Start 2006
Funding Finish 2013
GNo G0186914
Type Of Funding Internal
Category INTE
UON Y

Investigation of the association between chlamydial infection and asthma in different age groups$362,625

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Phil Hansbro, Conjoint Professor Kenneth Beagley, Conjoint Professor Peter Gibson
Scheme Project Grant
Role Investigator
Funding Start 2006
Funding Finish 2008
GNo G0185145
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Surveillance and Analysis of Avian Influenza Viruses in Migratory Birds in Australia$249,625

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Phil Hansbro, Dr Ian Barr, Conjoint Professor Peter Wark, Dr Paul Selleck, Dr Simone Warner, Laureate Professor Paul Foster, Dr Aeron Hurt, Dr Irene Peroulis, Dr John Curran, Conjoint Professor Peter Gibson
Scheme Potential Avian Influenza-Induced Pandemic
Role Investigator
Funding Start 2006
Funding Finish 2006
GNo G0186000
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

The relationship between eosinophilic inflammation, viral infection and severe asthma exacerbations during pregnancy$50,000

Funding body: Asthma Foundation of New South Wales

Funding body Asthma Foundation of New South Wales
Project Team Doctor Vanessa Murphy, Conjoint Associate Professor Vicki Clifton, Emeritus Professor Michael Hensley, Conjoint Professor Warwick Giles, Conjoint Professor Peter Gibson
Scheme Research Grant
Role Investigator
Funding Start 2006
Funding Finish 2006
GNo G0186029
Type Of Funding Donation - Aust Non Government
Category 3AFD
UON Y

The effect of maternal asthma and its treatment on placental and fetal glucocorticoid receptor expression$50,000

Funding body: Asthma Foundation of New South Wales

Funding body Asthma Foundation of New South Wales
Project Team Conjoint Associate Professor Vicki Clifton, Conjoint Professor Peter Gibson, Laureate Professor Roger Smith, Conjoint Professor Warwick Giles, Mrs Pip Talbot
Scheme Research Grant
Role Investigator
Funding Start 2006
Funding Finish 2006
GNo G0186137
Type Of Funding Donation - Aust Non Government
Category 3AFD
UON Y

Molecular Pathogenesis of Non-Eosinophilic Asthma$18,837

Funding body: Asthma Foundation of New South Wales

Funding body Asthma Foundation of New South Wales
Project Team Doctor Katie Baines, Conjoint Professor Peter Gibson
Scheme PhD Scholarships
Role Investigator
Funding Start 2006
Funding Finish 2006
GNo G0185985
Type Of Funding Donation - Aust Non Government
Category 3AFD
UON Y

20058 grants / $3,991,893

Markers of disease activity$3,002,002

Funding body: CRC for Asthma

Funding body CRC for Asthma
Project Team Conjoint Professor Peter Gibson
Scheme Research Grant
Role Lead
Funding Start 2005
Funding Finish 2011
GNo G0185871
Type Of Funding CRC - Cooperative Research Centre
Category 4CRC
UON Y

CCRE for Respiratory and Sleep Medicine$366,110

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Ronald Grunstein, Conjoint Professor Peter Gibson, Emeritus Professor Michael Hensley
Scheme Centres of Research Excellence (CRE) - Centres of Clinical Research Excellence
Role Lead
Funding Start 2005
Funding Finish 2009
GNo G0185684
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

The role of lycopene supplementation in the management of asthma$328,750

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Peter Gibson, Professor Manohar Garg
Scheme Project Grant
Role Lead
Funding Start 2005
Funding Finish 2007
GNo G0183939
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

2005 RIBG allocation$40,842

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Conjoint Professor Peter Gibson
Scheme Research Infrastructure Block Grant (RIBG)
Role Lead
Funding Start 2005
Funding Finish 2005
GNo G0185791
Type Of Funding Internal
Category INTE
UON Y

HPLC with electrochemical detector$25,000

Funding body: Ramaciotti Foundations

Funding body Ramaciotti Foundations
Project Team Conjoint Professor Peter Gibson, Associate Professor Lisa Wood
Scheme Major Equipment Award
Role Lead
Funding Start 2005
Funding Finish 2005
GNo G0185635
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Characterisation of non-invasive markers of airway inflammation in pregnancies complicated by asthma$12,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Conjoint Professor Peter Gibson
Scheme Project Grant
Role Lead
Funding Start 2005
Funding Finish 2005
GNo G0184704
Type Of Funding Internal
Category INTE
UON Y

Prevention of asthma by immunisation with pneumococcal cell walls$10,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Phil Hansbro, Laureate Professor Paul Foster, Conjoint Professor Kenneth Beagley, Conjoint Professor Peter Gibson
Scheme Project Grant
Role Investigator
Funding Start 2005
Funding Finish 2005
GNo G0184712
Type Of Funding Internal
Category INTE
UON Y

20049 grants / $1,125,462

Characteristics and mechanisms of persistent asthma after common cold virus infection$400,250

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Peter Gibson, Associate Professor Darren Shafren, Emeritus Professor Michael Hensley
Scheme Project Grant
Role Lead
Funding Start 2004
Funding Finish 2006
GNo G0182884
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Practitioner Fellowship in Asthma Research$319,375

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Peter Gibson
Scheme Practitioner Fellowships
Role Lead
Funding Start 2004
Funding Finish 2008
GNo G0183674
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Respiratory Medicine$269,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Vanessa Murphy, Conjoint Professor Peter Gibson
Scheme Port Waratah Coal Service Post-Doctoral Fellowship
Role Investigator
Funding Start 2004
Funding Finish 2006
GNo G0184012
Type Of Funding Donation - Aust Non Government
Category 3AFD
UON Y

Molecular Pathogensis of Non-Eosinphilic Asthma$37,837

Funding body: Asthma Foundation of New South Wales

Funding body Asthma Foundation of New South Wales
Project Team Conjoint Professor Peter Gibson, Professor Rodney Scott, Doctor Katie Baines
Scheme PhD Scholarships
Role Lead
Funding Start 2004
Funding Finish 2005
GNo G0183715
Type Of Funding Donation - Aust Non Government
Category 3AFD
UON Y

Evaluation of a stepwise approach to multi-disciplinary management of chronic cough$25,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Anne Vertigan, Professor Deborah Theodoros, Dr Alison Winkworth, Conjoint Professor Peter Gibson, Dr Colin Reid
Scheme Research Grant
Role Investigator
Funding Start 2004
Funding Finish 2004
GNo G0184016
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Bio-Rad iCycler iQ Real- Time PCR Detection System (the $25,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Peter Gibson
Scheme Equipment Grant
Role Lead
Funding Start 2004
Funding Finish 2004
GNo G0184299
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

Airway inflammation in childhood asthma$19,000

Funding body: Hunter Children`s Research Foundation

Funding body Hunter Children`s Research Foundation
Project Team Conjoint Professor Peter Gibson, Conjoint Associate Professor Bruce Whitehead, Emeritus Professor Michael Hensley
Scheme Research Grant
Role Lead
Funding Start 2004
Funding Finish 2004
GNo G0184567
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Innate immune activation in chronic obstructive pulmonary disease (COPD)$15,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Conjoint Professor Peter Gibson
Scheme Project Grant
Role Lead
Funding Start 2004
Funding Finish 2004
GNo G0183373
Type Of Funding Internal
Category INTE
UON Y

Modulation of immune responses in asthma by bacterial infections during early life.$15,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Phil Hansbro, Laureate Professor Paul Foster, Conjoint Professor Peter Gibson
Scheme Project Grant
Role Investigator
Funding Start 2004
Funding Finish 2004
GNo G0183512
Type Of Funding Internal
Category INTE
UON Y

20037 grants / $578,650

Non-eosinophilic asthma: mechanisms and treatment$430,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Peter Gibson, Conjoint Associate Professor Michael Boyle, Professor Rodney Scott
Scheme Project Grant
Role Lead
Funding Start 2003
Funding Finish 2005
GNo G0181776
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Modulation of immune responses in the asthmatic lung by bacterial infections.$50,000

Funding body: Asthma Foundation of New South Wales

Funding body Asthma Foundation of New South Wales
Project Team Professor Phil Hansbro, Conjoint Professor Peter Gibson, Conjoint Professor Kenneth Beagley, Dr Paul Foster
Scheme Research Grant
Role Investigator
Funding Start 2003
Funding Finish 2003
GNo G0183600
Type Of Funding Donation - Aust Non Government
Category 3AFD
UON Y

Sievers NOA 280i Nitric Oxide Analyser$36,650

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Peter Gibson, Conjoint Associate Professor Vicki Clifton, Conjoint Associate Professor Michael Boyle, Professor Rodney Scott
Scheme Equipment Grant
Role Lead
Funding Start 2003
Funding Finish 2003
GNo G0183059
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Inflammatory mechanisms in non-eosinophilic ashtma$20,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Conjoint Professor Peter Gibson, Conjoint Associate Professor Michael Boyle
Scheme Research Grant
Role Lead
Funding Start 2003
Funding Finish 2003
GNo G0182955
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Treatment of asthma by vaccination with bacterial antigens.$17,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor Phil Hansbro, Conjoint Professor Peter Gibson, Conjoint Professor Kenneth Beagley
Scheme Research Grant
Role Investigator
Funding Start 2003
Funding Finish 2003
GNo G0182627
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Carotenoids and flavonoids in asthma$15,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Conjoint Professor Peter Gibson, Professor Manohar Garg, Associate Professor Lisa Wood
Scheme Project Grant
Role Lead
Funding Start 2003
Funding Finish 2003
GNo G0182435
Type Of Funding Internal
Category INTE
UON Y

Sparke Helmore Prime Television Corporate Triathlon Award for Research Excellence$10,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Conjoint Professor Peter Gibson
Scheme Sparke Helmore/NBN Television Corporate Triathlon Award for Research Excellence
Role Lead
Funding Start 2003
Funding Finish 2003
GNo G0183641
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

20023 grants / $57,455

Modulation of inflammatory responses in the asthmatic lung by bacterial infection and vaccination.$24,842

Funding body: Asthma Foundation of New South Wales

Funding body Asthma Foundation of New South Wales
Project Team Ms Julie Preston, Conjoint Professor Peter Gibson, Professor Phil Hansbro
Scheme PhD Scholarships
Role Investigator
Funding Start 2002
Funding Finish 2004
GNo G0181606
Type Of Funding Donation - Aust Non Government
Category 3AFD
UON Y

Ultra Low Temperature Upright Freezer including Racks and Storage box for Viral Laboratory establishment$20,613

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Peter Gibson, Conjoint Associate Professor Michael Boyle, Emeritus Professor Michael Hensley, Associate Professor Darren Shafren
Scheme Equipment Grant
Role Lead
Funding Start 2002
Funding Finish 2002
GNo G0181920
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Treatment of asthma by vaccination with bacterial antigens$12,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Phil Hansbro, Conjoint Professor Peter Gibson, Conjoint Professor Kenneth Beagley
Scheme Project Grant
Role Investigator
Funding Start 2002
Funding Finish 2002
GNo G0181356
Type Of Funding Internal
Category INTE
UON Y

20014 grants / $527,506

Virus induced asthma: mechanisms and management.$390,475

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Peter Gibson, Conjoint Associate Professor Michael Boyle, Emeritus Professor Michael Hensley, Conjoint Professor Peter Jones, Associate Professor Darren Shafren
Scheme Project Grant
Role Lead
Funding Start 2001
Funding Finish 2003
GNo G0179694
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Airways infection and immunology$94,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Conjoint Professor Peter Gibson
Scheme NSW Dept Health - Infrastructure Funding
Role Lead
Funding Start 2001
Funding Finish 2002
GNo G0183306
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Thermo Labsystem Luminoskan Ascent - Microplate Luminometer$23,031

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Peter Gibson, Conjoint Associate Professor Michael Boyle, Emeritus Professor Michael Hensley, Conjoint Professor Peter Jones, Associate Professor Darren Shafren
Scheme Equipment Grant
Role Lead
Funding Start 2001
Funding Finish 2001
GNo G0181176
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Oxidative stress and the antioxidant defences in asthmatic airways in relation to disease severity.$20,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Conjoint Professor Peter Gibson, Professor Manohar Garg
Scheme Research Grant
Role Lead
Funding Start 2001
Funding Finish 2001
GNo G0181501
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

20001 grants / $238,678

Airway inflammation in allergic aspergillosis: characterisaion, immunologic mechanisms and treatment.$238,678

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Peter Gibson, Conjoint Associate Professor Michael Boyle, Emeritus Professor Michael Hensley, Dr Cliff Meldrum
Scheme Project Grant
Role Lead
Funding Start 2000
Funding Finish 2002
GNo G0178474
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

19983 grants / $147,000

Effect of severe asthma during pregnancy on placental function and fetal outcome$90,000

Funding body: Asthma Foundation of New South Wales

Funding body Asthma Foundation of New South Wales
Project Team Conjoint Associate Professor Vicki Clifton, Conjoint Professor Peter Gibson, Laureate Professor Roger Smith
Scheme Research Grant
Role Investigator
Funding Start 1998
Funding Finish 1999
GNo G0177659
Type Of Funding Donation - Aust Non Government
Category 3AFD
UON Y

The investigation of airway inflammation and cell death in acute severe asthma$45,500

Funding body: Asthma Foundation of New South Wales

Funding body Asthma Foundation of New South Wales
Project Team Conjoint Professor Peter Gibson, Conjoint Professor Peter Wark
Scheme Research Grant
Role Lead
Funding Start 1998
Funding Finish 1999
GNo G0177660
Type Of Funding Donation - Aust Non Government
Category 3AFD
UON Y

Effect of severe asthma during pregnancy on placental function and fetal outcome.$11,500

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Conjoint Associate Professor Vicki Clifton, Conjoint Professor Peter Gibson
Scheme Project Grant
Role Investigator
Funding Start 1998
Funding Finish 1998
GNo G0177211
Type Of Funding Internal
Category INTE
UON Y

19972 grants / $421,869

Airway inflamation in childhood asthma$248,105

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Peter Gibson, Professor Richard Henry
Scheme Project Grant
Role Lead
Funding Start 1997
Funding Finish 1999
GNo G0176233
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

The Molecular Basis of Phagocytosis of Apoptotic Granulocytes$173,764

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Gordon Burns, Conjoint Professor Peter Gibson
Scheme Project Grant
Role Investigator
Funding Start 1997
Funding Finish 1999
GNo G0176242
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

19941 grants / $113,065

Eosinophils, Mast Cells and Airway Inflammation in Asthma.$113,065

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Peter Gibson
Scheme Project Grant
Role Lead
Funding Start 1994
Funding Finish 1996
GNo G0173004
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

19913 grants / $165,674

The role of airway inflammatory cells, adhesion proteins and cytokines in asthma$129,906

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Peter Gibson, Dr Leslie Olson
Scheme Project Grant
Role Lead
Funding Start 1991
Funding Finish 1993
GNo G0174252
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

The Role Of Food Additives In Asthma$25,293

Funding body: Asthma Foundation of New South Wales

Funding body Asthma Foundation of New South Wales
Project Team Conjoint Professor Peter Gibson
Scheme Research Grant
Role Lead
Funding Start 1991
Funding Finish 1991
GNo G0173870
Type Of Funding Donation - Aust Non Government
Category 3AFD
UON Y

The Role Of Airway Inflammation In Asthma$10,475

Funding body: Rebecca L Cooper Medical Research Foundation Ltd

Funding body Rebecca L Cooper Medical Research Foundation Ltd
Project Team Conjoint Professor Peter Gibson
Scheme Research Grant
Role Lead
Funding Start 1991
Funding Finish 1991
GNo G0173992
Type Of Funding Donation - Aust Non Government
Category 3AFD
UON Y
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Research Supervision

Number of supervisions

Completed17
Current4

Total current UON EFTSL

PhD1.05

Current Supervision

Commenced Level of Study Research Title / Program / Supervisor Type
2015 PhD The effects of Galectin-3 on alveolar macrophage function in asthma
PhD (Medicine), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2014 PhD Physical Activity and Sedentary Behaviour in Obstructive Airway Diseases
PhD (Medicine), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2013 PhD The Role of Comorbidities and Inflammation in COPD
PhD (Medicine), Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2011 PhD Immunoregulatory Therapies for Inflammatory Diseases
PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor

Past Supervision

Year Level of Study Research Title / Program / Supervisor Type
2015 PhD Immunometabolism in Obese Asthma
PhD (Medicine), Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2014 PhD Epigenetic Regulation of Airway Inflammation in Asthma
PhD (Medicine), Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2014 PhD Systemic Inflammation in Obstructive Airway Disease
PhD (Medicine), Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2013 PhD Paediatric Obesity, Inflammation and Asthma
PhD (Medicine), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2013 PhD Investigation of the Immune Mechanisms in Pregnancy and Asthma Leading to Increased Susceptibility and Disease Severity to Respiratory Virus Infections
PhD (Medicine), Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2012 PhD Exploring the Link Between Obesity and Asthma
PhD (Medicine), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2011 PhD A Streptococcus pneumoniae-based Immunoregulatory Therapy for Asthma
PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2011 PhD Asthma and COPD in Older People
PhD (Medicine), Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2011 PhD Laryngeal Dysfunction in Chronic Cough
PhD (Medicine), Faculty of Health and Medicine, The University of Newcastle
Sole Supervisor
2009 PhD Nutritional Modulation of Lung Inflammation
PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2009 PhD Evidence-Based Implementation of Evidence-Based Asthma Guidelines in Rural Hospital Emergency Departments
PhD (Medicine), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2008 PhD Modulation of Responses in the Asthmatic Lung by Chlamydial Infection
PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2008 PhD Airway Inflammation in School-Aged Children with Asthma
PhD (Medicine), Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2008 PhD Role of Lycopene and Long Chain n-3 Polyunsaturated Fatty Acid Supplements in Airway Inflammation
PhD (Human Physiology), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2008 PhD Molecular Pathogenesis of Non - Eosinophilic Asthma
PhD (Medical Genetics), Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2007 PhD Modulation of Responses in the Asthmatic Lung by Streptococcus Pneumoniae
PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2005 PhD Inflammatory Mechanisms in Non-Eosinophilic Asthma
PhD (Medicine), Faculty of Health and Medicine, The University of Newcastle
Sole Supervisor
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Research Collaborations

The map is a representation of a researchers co-authorship with collaborators across the globe. The map displays the number of publications against a country, where there is at least one co-author based in that country. Data is sourced from the University of Newcastle research publication management system (NURO) and may not fully represent the authors complete body of work.

Country Count of Publications
Australia 542
United Kingdom 49
United States 31
China 26
New Zealand 20
More...
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News

Associate Professor Vanessa McDonald

Weight-loss study challenges COPD’s obesity puzzle

February 29, 2016

Faced with a clinical paradox where obesity seemingly offers a protective effect for Chronic Obstructive Pulmonary Disease (COPD), Hunter researchers have performed a world-first pilot study aimed at achieving weight loss without exacerbating respiratory symptoms.

New study to examine fibre effect on asthma

June 15, 2015

Respiratory researchers from the University of Newcastle and HMRI are looking into whether a high-fibre diet can reduce airway inflammation in people with asthma.

Asthma antibiotics

Asthma study trials antibiotic therapy

August 7, 2014

A national study investigating the use of antibiotics as a potential therapy for chronic asthma attacks is entering its final recruitment phase, five years after it commenced.

Professor Peter Gibson

Professor Gibson to present at NSW Asthma Foundation

November 11, 2013

The University of Newcastle's Conjoint Professor Peter Gibson will be presenting at the NSW Asthma Foundation's AGM on Tuesday 26 November 2013.

Conjoint Professor Peter Gibson

Position

Conjoint Professor
Centre for Asthma and Respiratory Diseases
School of Medicine and Public Health
Faculty of Health and Medicine

Contact Details

Email peter.gibson@newcastle.edu.au
Phone 40420143
Mobile 0408963976
Fax 40420046

Office

Room Rm 2102, West Wing Level 2, HMRI
Building HMRI Building, 1 Kookaburra Circuit, JHH Campus
Location HMRI - John Hunter Hospital Campus

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