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Emeritus Professor Peter Dunkley

Emeritus Professor

School of Biomedical Sciences and Pharmacy (Medical Biochemistry)

Career Summary

Biography

Professor Dunkley's research is focused on signal transduction in neuronal and endocrine tissues and especially on protein phosphorylation. Professor Dunkley has published 108 articles in peer reviewed journals and a further 14 refereed reviews and book chapters. His life time citations are 2880, his h-index is 27 and his average number of citations per article is 28. In 2011 the number of citations was over 160. Professor Dunkley was invited by Nature Protocols to write a protocol based on two of his earlier papers which have together been cited 637 times.

Since 2004 he has worked on the activation of tyrosine hydroxylase by protein phosphorylation and his review in J Neurochemistry has been cited 145 times. Professor Dunkley has maintained a strong collaboration and mentoring role with young researchers in Brazil and has published 20 papers with these colleagues. Professor Dunkley has a post-doctoral fellow and two PhD students working with him in 2012. Grants: Professor Dunkley had continuous support from the NHMRC for 31 years until he retired for research in which he was the first named chief investigator. He has also been involved in many other collaborative NHMRC grants as a secondary CI. Professor Dunkley has also had grants from the ARC and many other funding agencies. Recognition: Professor Dunkley has presented his research at 7 overseas conferences over the last 10 years with 5 being invited presentations.

In 2002 Professor Dunkley received the Hunter Medical Research Institute award for research excellence in the form of a $10,000 prize. Professor Dunkley has been the neuroscience representative on the ARC biological sciences panel for 3 years and on an NHMRC RGIC on four occasions, including being the deputy chair of the cellular neuroscience panel in 1999 and deputy chair of the molecular neuroscience panel in 2006. He was on the Medicine and Public Health committee of the ERA in 2010 and the New Zealand PBRF committee in 2012. Professor Dunkley was the President (2002-2003) of the International Society for Neurochemistry (ISN). He still serves as a member of the ISN finance committee. In addition he is a member of the Asian Pacific Society for Neurochemistry (APSN) council. Professor Dunkley was the Foundation Head of The School of Biomedical Sciences at The University of Newcastle (1998-2002) and was the Pro Vice-Chancellor (Health) in 2010-2011. In 2012 he was the Director of the Hunter Medical Research Institute.

Research Expertise

My basic training is that of a protein chemist and I work in the field of cellular and molecular biology. My research focuses on signal transduction mechanisms in neuronal and endocrine tissues and especially on protein phosphorylation. I have focused on a number of key proteins and especially myelin basic protein that is essential for myelin structure, synapsin I that controls neurotransmitter release and tyrosine hydroxylase that is the rate limiting enzyme in catecholamine synthesis. I have investigated these proteins in the context of diseases including Multiple Sclerosis, Parkinsons' disease, depression and anxiety. My focus recently has been on been investigating the phosphorylation of tyrosine hydroxylase at Ser19, Ser31 and Ser40 and tyrosine hydroxylase activity in a number of tissues from the brain and from the adrenal medulla; the tissues have been collected from a range of animal models of stress and from human postmortem Parkinsons' disease patients. I have also had an interest in nutritional biochemistry undertaking occasional studies on the uptake of dissolved nutrients in the Sydney rock oyster; the use of blood glucose monitors in diabetics; the teratogenic and oxidative consequences of ethanol consumption and the effects of vitamin A deficiency on gastrointestinal structure and function.

Teaching Expertise
B Nutrition and Dietetics Professional Skills for Laboratory Scientists-B Biomedical Science Biomedical Sciences Degree and Biomedical Science Hons International Development Programme Visiting Medical Specialist B Medicine

Administrative Expertise
Member of the Griffith and University of Western Sydney Medical School Strategic Advisory Groups Foundation Head, School of Biomedical Sciences Member of the Executive of Faculty of Medicine and Health Sciences Co-ordinator of Space for the Campus University Strategic Planning Task Force elected by Academic Senate Assistant Dean Finance and Personnel/Deputy Director, Medical School University Planning and Resources Committee elected by the University Senate Faculty of Medicine Structure Review Committee Head of Medical Biochemistry (1988-1999).


Qualifications

  • PhD, University of Melbourne
  • Bachelor of Science, University of Melbourne
  • Bachelor of Science (Honours), University of Melbourne

Keywords

  • Biochemistry
  • Catecholamines
  • Depression
  • Medical Biochemistry
  • Neurochemistry
  • Neuroscience
  • Parkinsons' disease
  • Protein chemistry
  • Signal transduction
  • Tyrosine hydroxylase
  • protein phosphorylation

Fields of Research

CodeDescriptionPercentage
110199Medical Biochemistry and Metabolomics not elsewhere classified10
060199Biochemistry and Cell Biology not elsewhere classified40
110999Neurosciences not elsewhere classified50

Professional Experience

UON Appointment

DatesTitleOrganisation / Department
4/08/2014 - 18/12/2014One Off - Casual LecturerUniversity of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
1/01/2014 - 14/02/2014HMRI Strategic ConsultantUniversity of Newcastle
Faculty of Health and Medicine
Australia
5/12/2011 - 30/03/2012DirectorUniversity of Newcastle
Faculty of Health
Australia
1/07/2010 - 9/12/2010Casual LecturerUniversity of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
15/06/2010 - 1/07/2010Pro Vice-ChancellorUniversity of Newcastle
Office PVC - Health
Australia

Academic appointment

DatesTitleOrganisation / Department
1/01/2007 - 1/12/2007Invited to Chair Molecular Neuroscience PanelNHMRC (National Health & Medical Research Council)
1/01/2006 - 1/12/2006Consultant in Restrospective Analysis of Research GrantsNHMRC (National Health & Medical Research Council)
1/01/2006 - 1/12/2006Deputy Chair Molecular Neuroscience PanelNHMRC (National Health & Medical Research Council)
1/01/2005 - 1/07/2005Consultant in Biomedical SciencesUniversity of Western Sydney
Australia
1/01/2005 - 1/06/2006Consultant in Biomedical SciencesGriffith University
Australia
1/01/2001 - 1/12/2003PresidentInternational Society for Neurochemistry
United Kingdom
1/01/2000 - 1/12/2000Deputy Chair Neuroscience DPNHMRC (National Health & Medical Research Council)
1/01/1998 - 1/12/2001TreasurerInternational Society for Neurochemistry
United Kingdom
1/01/1997 - 1/12/2001Foundation Head of School of Biomedical Sciences
Biomedical Sciences
University of Newcastle
School of Health
Australia
1/01/1994 - 1/07/2010Professor of Medical BiochemistryUniversity of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
1/01/1988 - 1/12/1993Associate Professor Medical Biochemistry
Medical Biochemistry
University of Newcastle
Faculty of Medicine
Australia
1/01/1982 - 1/12/1987Senior Lecturer
Medical Biochemistry
University of Newcastle
Faculty of Medicine
Australia
1/02/1978 - 1/12/1981Foundation Lecturer in Medical BiochemistryUniversity of Newcastle
Faculty of Medicine
Australia
1/09/1976 - 1/02/1978Research ScientistCSIRO- Plant Biochemistry
Australia
1/01/1975 - 1/09/1976Exhibition for 1851 FellowInstitute of Psychiatry, London
Biochemistry; Neurochemistry
United Kingdom

Membership

DatesTitleOrganisation / Department
Member - The American Society for NeurochemistryThe American Society for Neurochemistry
United States
Member - International Society for NeurochemistryThe International Society for Neurochemistry
Australia
Member - The Australian Society for Biochemistry and Molecular BiologyThe Australian Society for Biochemistry and Molecular Biology
Australia
1/07/2011 - 1/12/2012MemberNew Zealand Performance Based Research Fund
New Zealand
1/01/2010 - 1/12/2010MemberERA Medicine and Public Health Committee
Australia
1/01/1996 - 31/12/1998Member - AO Biological Sciences CommitteeAO Biological Sciences Committee 1996-1998
Australia
1/01/1993 - 31/12/1997Member - Journal of NeurochemistryJournal of Neurochemistry
Australia
1/01/1992 - 31/12/1995Member - European Journal of PharmacologyEuropean Journal of Pharmacology
Australia
1/01/1992 - 31/12/1994Member -NHMRC RGIC CommitteesNHMRC RGIC Committees
Australia
1/01/1991 - 31/12/1994Member - Journal of Molecular NeuroscienceJournal of Molecular Neuroscience
Australia

Professional appointment

DatesTitleOrganisation / Department
1/12/2011 - 1/04/2012Director Hunter Medical Research InstituteUniversity of Newcastle
Health
Australia

Teaching appointment

DatesTitleOrganisation / Department
1/01/1974 - 1/12/1974Senior TutorThe University of Melbourne
Department of Biochemistry
Australia

Awards

Research Award

YearAward
2002Award for Research Excellence
HMRI

Invitations

Keynote Speaker

YearTitle / Rationale
2011The Laurie Austin Lecture
Organisation: Australian Neuroscience Society
2008IBN Lecture
Organisation: Brazil Neuroscience Society

Participant

YearTitle / Rationale
2002Plenary Lecturer
Organisation: Japanese Society for Neurochemistry
Edit

Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Journal article (143 outputs)

YearCitationAltmetricsLink
2014Ong LK, Guan L, Damanhuri H, Goodchild AK, Bobrovskaya L, Dickson PW, Dunkley PR, 'Neurobiological consequences of acute footshock stress: effects on tyrosine hydroxylase phosphorylation and activation in the rat brain and adrenal medulla', JOURNAL OF NEUROCHEMISTRY, 128 547-560 (2014) [C1]
DOI10.1111/jnc.12482Author URL
CitationsScopus - 2Web of Science - 1
Co-authorsPhil Dickson, Linkooi Ong
2014Stutz B, Lima da Conceicao FS, Santos LE, Cadilhe DV, Fleming RL, Acquarone M, et al., 'Murine dopaminergic Muller cells restore motor function in a model of Parkinson's disease', JOURNAL OF NEUROCHEMISTRY, 128 829-840 (2014) [C1]
DOI10.1111/jnc.12475Author URL
CitationsScopus - 2Web of Science - 2
Co-authorsPhil Dickson
2013Briggs G, Bulley J, Dunkley PR, Dickson PW, 'Structural Basis for Regulation of Tyrosine Hydroxlyase by the Catecholamines 8-9 (2013) [E3]
DOI10.1016/B978-0-12-800044-1.00006-4
Co-authorsPhil Dickson
2013Bobrovskaya L, Maniam J, Ong LK, Dunkley PR, Morris MJ, 'Early Life Stress and Post-Weaning High Fat Diet Alter Tyrosine Hydroxylase Regulation and AT1 Receptor Expression in the Adrenal Gland in a Sex Dependent Manner', NEUROCHEMICAL RESEARCH, 38 826-833 (2013) [C1]
DOI10.1007/s11064-013-0985-4Author URL
CitationsScopus - 1Web of Science - 1
Co-authorsLinkooi Ong
2013Sominsky L, Fuller EA, Bondarenko E, Ong LK, Averell L, Nalivaiko E, et al., 'Functional Programming of the Autonomic Nervous System by Early Life Immune Exposure: Implications for Anxiety', PLOS ONE, 8 (2013) [C1]
DOI10.1371/journal.pone.0057700Author URL
CitationsScopus - 9Web of Science - 10
Co-authorsLinkooi Ong, Eugene Nalivaiko, Deborah Hodgson, Phil Dickson
2012Dunkley PR, 'Richard Burnard Rodnight, 1921-2012 [Obituary]', Journal of Neurochemistry, 123 199-201 (2012) [C3]
CitationsScopus - 1Web of Science - 1
2012Ong LK, Sominsky L, Dickson PW, Hodgson DM, Dunkley PR, 'The sustained phase of Tyrosine hydroxylase activation in vivo', Neurochemical Research, 37 1938-1943 (2012) [C1]
CitationsScopus - 6Web of Science - 5
Co-authorsLinkooi Ong, Deborah Hodgson, Phil Dickson
2012Barreto RDA, Walker FR, Dunkley PR, Day TA, Smith DW, 'Fluoxetine prevents development of an early stress-related molecular signature in the rat infralimbic medial prefrontal cortex. Implications for depression?', BMC Neuroscience, 13 1-12 (2012) [C1]
CitationsScopus - 5Web of Science - 7
Co-authorsDouglas Smith, Trevor Day, Rohan Walker
2012Dayas CV, Smith DW, Dunkley PR, 'An emerging role for the mammalian Target of Rapamycin (mTOR) in 'pathological' protein translation: Relevance to cocaine addiction', Frontiers in Pharmacology, 3 1-12 (2012) [C1]
CitationsScopus - 9Web of Science - 7
Co-authorsChristopher Dayas, Douglas Smith
2012Damanhuri HA, Burke PGR, Ong LK, Bobrovskaya L, Dickson PW, Dunkley PR, Goodchild AK, 'Tyrosine hydroxylase phosphorylation in catecholaminergic brain regions: A marker of activation following acute hypotension and glucoprivation', Plos One, 7 1-19 (2012) [C1]
CitationsScopus - 10Web of Science - 7
Co-authorsLinkooi Ong, Phil Dickson
2011Ong LK, Guan L, Stutz B, Dickson PW, Dunkley PR, Bobrovskaya L, 'The effects of footshock and immobilization stress on tyrosine hydroxylase phosphorylation in the rat locus coeruleus and adrenal gland', Neuroscience, 192 20-27 (2011) [C1]
DOI10.1016/j.neuroscience.2011.06.087
CitationsScopus - 7Web of Science - 7
Co-authorsPhil Dickson, Linkooi Ong
2011Ong LK, Bobrovskaya L, Walker FR, Day TA, Dickson PW, Dunkley PR, 'The effect of social defeat on tyrosine hydroxylase phosphorylation in the rat brain and adrenal gland', Neurochemical Research, 36 27-33 (2011) [C1]
DOI10.1007/s11064-010-0255-7
CitationsScopus - 7Web of Science - 7
Co-authorsLinkooi Ong, Phil Dickson, Rohan Walker, Trevor Day
2010Bobrovskaya L, Damanhuri HA, Ong LK, Schneider JJ, Dickson PW, Dunkley PR, Goodchild AK, 'Signal transduction pathways and tyrosine hydroxylase regulation in the adrenal medulla following glucoprivation: An in vivo analysis', Neurochemistry International, 57 162-167 (2010) [C1]
DOI10.1016/j.neuint.2010.05.009
CitationsScopus - 11Web of Science - 11
Co-authorsJennifer Schneider, Phil Dickson, Linkooi Ong
2010Double KL, Halliday GM, Dunkley PR, Dickson PW, Gerlach M, Riederer P, 'Pigmentation in the human brain and risk of Parkinson's Disease', Annals of Neurology, 67 553-554 (2010) [C3]
CitationsScopus - 2Web of Science - 1
Co-authorsPhil Dickson
2010Posser T, Dunkley PR, Dickson PW, Franco JL, 'Human neuroblastoma cells transfected with tyrosine hydroxylase gain increased resistance to methylmercury-induced cell death', Toxicology in Vitro, 24 1498-1503 (2010) [C1]
DOI10.1016/j.tiv.2010.07.015
CitationsScopus - 8Web of Science - 9
Co-authorsPhil Dickson
2010Franco JL, Posser T, Gordon SL, Bobrovskaya L, Schneider JJ, Farina M, et al., 'Expression of tyrosine hydroxylase increases the resistance of human neuroblastoma cells to oxidative insults', Toxicological Sciences, 113 150-157 (2010) [C1]
DOI10.1093/toxsci/kfp245
CitationsScopus - 10Web of Science - 8
Co-authorsJennifer Schneider, Phil Dickson
2009Posser T, Franco JL, Bobrovskaya L, Leal RB, Dickson PW, Dunkley PR, 'Manganese induces sustained Ser40 phosphorylation and activation of tyrosine hydroxylase in PC12 cells', Journal of Neurochemistry, 110 848-856 (2009) [C1]
DOI10.1111/j.1471-4159.2009.06185.x
CitationsScopus - 16Web of Science - 13
Co-authorsPhil Dickson
2009Gordon SL, Bobrovskaya L, Dunkley PR, Dickson PW, 'Differential regulation of human tyrosine hydroxylase isoforms 1 and 2 in situ: Isoform 2 is not phosphorylated at Ser35', Biochimica et Biophysica Acta - Molecular Cell Research, 1793 1860-1867 (2009) [C1]
DOI10.1016/j.bbamcr.2009.10.001
CitationsScopus - 21Web of Science - 21
Co-authorsPhil Dickson
2009Gordon SL, Webb JK, Shehadeh J, Dunkley PR, Dickson PW, 'The low affinity dopamine binding site on tyrosine hydroxylase: The role of the N-Terminus and in situ regulation of enzyme activity', Neurochemical Research, 34 1830-1837 (2009) [C1]
DOI10.1007/s11064-009-9989-5
CitationsScopus - 7Web of Science - 6
Co-authorsPhil Dickson
2009Franco JL, Posser T, Dunkley PR, Dickson PW, Mattos JJ, Martins R, et al., 'Methylmercury neurotoxicity is associated with inhibition of the antioxidant enzyme glutathione peroxidase', Free Radical Biology and Medicine, 47 449-457 (2009) [C1]
DOI10.1016/j.freeradbiomed.2009.05.013
CitationsScopus - 70Web of Science - 66
Co-authorsPhil Dickson
2008Dunkley PR, Jarvie P, Robinson PJ, 'A rapid Percoll gradient procedure for preparation of synaptosomes', Nature Protocols, 3 1718-1728 (2008) [C1]
DOI10.1038/nprot.2008.171
CitationsScopus - 89Web of Science - 85
2008Gordon SL, Quinsey NS, Dunkley PR, Dickson PW, 'Tyrosine hydroxylase activity is regulated by two distinct dopamine-binding sites', Journal of Neurochemistry, 106 1614-1623 (2008) [C1]
DOI10.1111/j.1471-4159.2008.05509.x
CitationsScopus - 19Web of Science - 18
Co-authorsPhil Dickson
2007Bobrovskaya L, Gelain DP, Gilligan C, Dickson PW, Dunkley PR, 'PACAP stimulates the sustained phosphorylation of tyrosine hydroxylase at serine 40', Cellular Signalling, 19 1141-1149 (2007) [C1]
DOI10.1016/j.cellsig.2006.12.006
CitationsWeb of Science - 33
Co-authorsPhil Dickson, Conor Gilligan
2007Bobrovskaya L, Gilligan C, Bolster EK, Flaherty JJ, Dickson PW, Dunkley PR, 'Sustained phosphorylation of tyrosine hydroxylase at serine 40: a novel mechanism for maintenance of catecholamine synthesis', Journal of Neurochemistry, 100 479-489 (2007) [C1]
DOI10.1111/j.1471-4159.2006.04213.x
CitationsScopus - 48Web of Science - 48
Co-authorsConor Gilligan, Phil Dickson
2007Gelain DP, Moreira JCF, Bevilaqua LRM, Dickson PW, Dunkley PR, 'Retinol activates tyrosine hydroxylase acutely by increasing the phosphorylation of serine40 and then serine31 in bovine adrenal chromaffin cells', Journal of Neurochemistry, 103 2369-2379 (2007) [C1]
DOI10.1111/j.1471-4159.2007.04935.x
CitationsScopus - 14Web of Science - 14
Co-authorsPhil Dickson
2007Leal RB, Posser T, Rigon AP, Oliveira CS, Goncalves CA, Gelain DP, Dunkley PR, 'Cadmium stimulates MAPKs and Hsp27 phosphorylation in bovine adrenal chromaffin cells', Toxicology, 234 34-43 (2007) [C1]
DOI10.1016/j.tox.2007.01.023
CitationsWeb of Science - 19
2006Lehmann IT, Bobrovskaya L, Gordon SL, Dunkley PR, Dickson PW, 'Differential regulation of the human tyrosine hydroxylase isoforms via hierarchical phosphorylation', Journal of Biological Chemistry, 281 17644-17651 (2006) [C1]
DOI10.1074/jbc.M512194200
CitationsScopus - 44Web of Science - 45
Co-authorsPhil Dickson
2005Cechin SR, Dunkley PR, Rodnight RB, 'Signal transduction mechanisms involved in the proliferation of C6 glioma cells induced by lysophosphatidic acid', Neurochemical Research, 30 603-611 (2005) [C1]
DOI10.1007/s11064-005-2747-4
CitationsScopus - 28Web of Science - 26
2005Graham ME, Dickson PW, Dunkley PR, Von Nagy-Felsobuki EI, 'Characterisation of tryptic peptides of phosphorylated tyrosine hydroxylase by high-pressure liquid chromatography electrospray ionisation mass spectrometry', Journal of Electron Spectroscopy and Related Phenomena, 142 271-276 (2005) [C1]
DOI10.1016/j.elspec.2004.09.008
CitationsScopus - 2Web of Science - 2
Co-authorsPhil Dickson, Ellak
2004Cordova FM, Rodrigues ALS, Giacomelli MBO, Oliveira CS, Posser T, Dunkley PR, Leal RB, 'Lead stimulates ERK1/2 and p38MAPK phosphorylation in the hippocampus of immature rats', Brain Research, 998 65-72 (2004) [C1]
DOI10.1016/j.brainres.2003.11.012
CitationsScopus - 50Web of Science - 51
2004Ma FY, Grattan DR, Bobrovskaya L, Dunkley PR, Bunn SJ, 'Angiotensin II regulates tyrosine hydroxylase activity and mRNA expression in rat mediobasal hypothalamic cultures: the role of specific protein kinases', Journal of Neurochemistry, 90 431-441 (2004) [C1]
DOI10.1111/j.1471-4159.2004.02492.x
CitationsScopus - 14Web of Science - 15
2004Dunkley PR, Bobrovskaya L, Graham ME, Von Nagy-Felsobuki EI, Dickson PW, 'Tyrosine hydroxylase phosphorylation: regulation and consequences', Journal of Neurochemistry, 91 1025-1043 (2004) [C1]
DOI10.1111/j.1471-4159.2004.02797.x
CitationsScopus - 224Web of Science - 226
Co-authorsPhil Dickson, Ellak
2004Roberts-Thomson EL, Herd LM, Saunders H, Dunkley PR, Bunn SJ, 'The tryrosine phosphorylation and cytoskeletal translocation of phospholipase Cy1 in bovine adrenal medullary chromaffin cells', Neurochemical Research, 29 1847-1855 (2004) [C1]
DOI10.1023/B:NERE.0000042211.76499.c6
CitationsScopus - 1Web of Science - 1
Co-authorsLynn Herd
2004Frizzo JK, Tramontina F, Bortoli E, Gottfried C, Leal RB, Lengyel I, et al., 'S100B-Mediated Inhibition of the Phosphorylation of GFAP Is Prevented by TRTK-12', Neurochemical Research, 29 735-740 (2004) [C1]
DOI10.1023/B:NERE.0000018844.51009.40
CitationsScopus - 23
2004Roberts-Thomson EL, Herd LM, Saunders HI, Dunkley PR, Bunn SJ, 'The tyrosine [correction of tryrosine] phosphorylation and cytoskeletal translocation of phospholipase C gamma 1 in bovine adrenal medullary chromaffin cells.', Neurochemical research, 29 1847-1855 (2004)
DOI10.1023/b:nere.0000042211.76499.c6
2004Leal RB, Frizzo JK, Tramontina F, Fieuw-Makaroff S, Bobrovskaya L, Dunkley PR, Goncalves CA, 'S1009B protein stimulates calcineurin activity', NEUROREPORT, 15 317-320 (2004)
DOI10.1097/01.wnr.0000109328.44017e9Author URL
CitationsWeb of Science - 10
2004Leal RB, Frizzo JK, Tramontina F, Fieuw-Makaroff S, Bobrovskaya L, Dunkley PR, Goncalves C-A, 'S100B protein stimulates calcineurin activity', NeuroReport, 15 317-320 (2004) [C1]
DOI10.1097/00001756-200402090-00021
CitationsScopus - 11
2003Cammarota MP, Bevilaqua L, Rostas JA, Dunkley PR, 'Histamine activates tyrosine hydroxylase in bovine adrenal chromaffin cells through a pathway that involves ERK1/2 but not p38 or JNK', Journal of Neurochemistry, 84 453-458 (2003) [C1]
DOI10.1046/j.1471-4159.2003.01517.x
CitationsScopus - 25Web of Science - 25
Co-authorsJohn Rostas
2003Bevilaqua L, Cammarota MP, Dickson PW, Sim AT, Dunkley PR, 'Role of protein phosphatase 2C from bovine adrenal chromaffin cells in the dephosphorylation of phospho-serine 40 tyrosine hydroxylase', Journal of Neurochemistry, 85 1368-1373 (2003) [C1]
DOI10.1046/j.1471-4159.2003.01792.x
CitationsScopus - 18Web of Science - 18
Co-authorsAlistair Sim, Phil Dickson
2003Powis DA, Zerbes M, Herd LM, Dunkley PR, 'Angiotensin II Causes Calcium Entry into Bovine Adrenal Chromaffin Cells via Pathway(s) Activated by Depletion of Intracellular Calcium Stores', Neurochemical Research, 28 1299-1306 (2003) [C1]
DOI10.1023/A:1024987128090
Co-authorsLynn Herd
2002Leal R, Cordova F, Herd LM, Bobrovskaya L, Dunkley PR, 'Lead-Stimulated p38 MARK-Dependent Hsp27 Phosphorylation', Toxicology and Applied Pharmacology, 178 44-51 (2002) [C1]
CitationsScopus - 38Web of Science - 39
Co-authorsLynn Herd
2002Leal R, Sim AT, Goncalves C, Dunkley PR, 'Tyrosine Hydroxylase Dephosphorylation by Protein Phosphatase 2A in Bovine Adrenal Chromaffin Cells', Neurochemical Research, 27, No 3 207-213 (2002) [C1]
CitationsScopus - 23Web of Science - 23
Co-authorsAlistair Sim
2002Warden RA, Noltorp RA, Bell CJ, O'Loughlin EV, Dunkley PR, Garg ML, 'Vitamin A Deficiency Changes Jejunal Mucosal Fatty Acid Profile in Rats', Journal of Clinical Biochemistry and Nutrition, 31 19-26 (2002) [C1]
CitationsScopus - 1Web of Science - 1
Co-authorsManohar Garg
2002Graham ME, Bevilaqua LRM, Phillip, Dickson W, Dunkley PR, Von Nagy-Felsobuki EI, 'Kinetic monitoring of protein phosphorylation using quantitative electrospray lonization mass spectrometry', Proceedings 50th ASMS Conference on Mass Spectrometry and Allied Topics, 301-302 (2002)

A kinetic model of protein phosphorylation using quantitative electrospray ionization mass spectrometry (ESI-MS) was discussed. Rate constants were determined in the absence of dopamine only. The analysis showed that the rate of serine 40 phosphorylation was two to three times higher when serine 19 was already phosphorylated. The application of quantitative ESI-MS to enzyme kinetics to provide information on protein structure/function was also demonstrated.

2001Bevilaqua L, Graham ME, Dunkley PR, Von Nagy-Felsobuki EI, Dickson PW, 'Phosphorylation of Ser19 Alters the Conformation of Tyrosine Hydroxylase to Increase the Rate of Phosphorylation of Ser40*', The Journal of Biological Chemistry, 276 No. 44 40411-40416 (2001) [C1]
CitationsScopus - 62Web of Science - 63
Co-authorsPhil Dickson
2001Leal RB, Cordova FM, Lynn H, Dunkley PR, 'Lead and cadmium stimulate HSP27 phosphorylation in bovine adrenal chromaffin cells', JOURNAL OF NEUROCHEMISTRY, 78 194-194 (2001)
Author URL
2001Bobrovskaya L, Odell AF, Leal RB, Dunkley PR, 'Tyrosine hydroxylase phosphorylation in bovine adrenal chromaffin cells: the role of MAPKs after angiotensin II stimulation', Journal of Neurochemistry, 78 490-498 (2001) [C1]
CitationsWeb of Science - 29
2001Cammarota MP, Bevilaqua L, Dunkley PR, Rostas JA, 'Angiotensin II Promotes the Phosphorylation of Cyclic AMP-Responsive Element Binding Protein (CREB) at Ser133 Through an ERK1/2-Dependent Mechanism', Journal of Neurochemistry, 79 1122-1128 (2001) [C1]
CitationsScopus - 32Web of Science - 31
Co-authorsJohn Rostas
2001Bevilaqua L, Graham ME, Von Nagy-Felsobuki EI, Dunkley PR, Dickson PW, 'Effect of phosphorylation on tyrosine hydroxylase shape', Journal of Neurochemistry, 78 Supt. 1 143 (2001) [C3]
Co-authorsPhil Dickson
2001Cammarota MP, Bevilaqua L, Dunkley PR, Rostas JA, 'Angiotensin II Promotes a Rapid and Reversible Increase in SRC-Tyrosine Kinase Activity in Bovine Adrenal Chromaffin Cells: Effect on MAPK Pathways', Proceedings of the Australian Neuroscience Society, 12 197 (2001) [C3]
Co-authorsJohn Rostas
2001Bobrovskaya L, Odell AF, Cheah TB, Dunkley PR, 'The Involvement of MAPKs in Angiotensin II-Stimulated Tyrosine Hydroxylase Phosphorylation in Bovine Adrenal Chromaffin Cells', Proceedings of the Australian Neuroscience Society, 12 85 (2001) [C3]
2001Graham ME, Bevilaqua L, Dunkley PR, Von Nagy-Felsobuki EI, Dickson PW, 'The Kinetics of CAMKII Phosphorylation of Dopamine Bound-Tyrosine Hydroxylase Determined by Electrospray Mass Spectrometry', ComBio 2001, 0 (2001) [C3]
Co-authorsPhil Dickson
2001Cammarota MP, Bevilaqua L, Dunkley PR, Rostas JA, 'Angiotensin II Promotes a Src and ERK 1/2 Dependent Increase in SER133-CREB Phosphorylation', Journal of Neurochemistry, 78 Supl. 1 143 (2001) [C3]
Co-authorsJohn Rostas
2000Karl J, Gottfried C, Tramontina F, Dunkley PR, Rodnight R, Goncalves CA, 'GFAP phosphorylation studied in digitonin-permeabilized astrocytes: standardization of conditions', Brain Research, 853 32-40 (2000) [C1]
CitationsWeb of Science - 14
2000Roberts-Thomson EL, Saunders H, Palmer SM, Powis DA, Dunkley PR, Bunn SJ, 'Ca2+ influx stimulated phospholipase C activity in bovine adrenal chromaffin cells: responses to K+ depolarization and histamine', European Journal of Pharmacology, 398 199-207 (2000) [C1]
CitationsWeb of Science - 8
2000Bobrovskaya L, Cheah TB, Dunkley PR, 'Angiotensin II-stimulated tyrosine hydroxylase activity and phosphorylation in bovine adrenal chromaffin cells', JOURNAL OF NEUROCHEMISTRY, 74 S38-S38 (2000)
Author URL
2000Lengyel I, Fieuw-Makaroff S, Hall AL, Sim AT, Rostas JA, Dunkley PR, 'Modulation of the Phosphorylation and Activity of Calcium/Calmodulin-Dependent Protein Kinase II by Zinc', Journal of Neurochemistry, 75 No. 2 594-605 (2000) [C1]
CitationsScopus - 51Web of Science - 51
Co-authorsAlistair Sim, John Rostas
2000Goncalves C-A, Gottfried C, Dunkley PR, 'The Use of Permeabilized Cells to Assay Protein Phosphorylatioon and Catecholamine Release', Neurochemical Research, 25 No. 6 885-894 (2000) [C1]
CitationsWeb of Science - 8
2000Graham ME, Dickson PW, Dunkley PR, Von Nagy-Felsobuki EI, 'Determination of Phosphorylation Levels of Tyrosine Hydroxylase by Electrospray Mass Spectrometry', Analytical Biochemistry, 280 1-7 (2000) [C1]
CitationsWeb of Science - 8
Co-authorsEllak, Phil Dickson
1999Bobrovskaya L, Cheah TB, Dunkley PR, 'Phorbol ester-mediated phosphorylation of tyrosine hydroxylase in bovine adrenal chromaffin cells', JOURNAL OF NEUROCHEMISTRY, 72 S25-S25 (1999)
Author URL
1999Lengyel I, Hall AL, Fieuw-Makaroff S, Sim ATR, Rostas JAP, Dunkley PR, 'Characterization of the zinc-dependent autophosphorylation sites on calcium/calmodulin-dependent protein kinase II', JOURNAL OF NEUROCHEMISTRY, 73 S33-S33 (1999)
Author URL
Co-authorsJohn Rostas
1999Bobrovskaya L, Dickson P, Cheah TB, Dunkley PR, 'The role of mitogen-activated protein kinase in tyrosine hydroxylase phosphorylation.', JOURNAL OF NEUROCHEMISTRY, 73 S34-S34 (1999)
Author URL
1999Roberts-Thomson EL, Saunders HI, Dunkley PR, Bunn SJ, 'The effect of insulin on phospholipase C activity in bovine adrenal medullary chromaffin cells.', JOURNAL OF NEUROCHEMISTRY, 73 S50-S50 (1999)
Author URL
1999Cheah TB, Bobrovskaya L, Goncalves C-A, Hall RM, Elliot R, Lengyel I, et al., 'Simultaneous measurement of tyrosine hydroxylase activity and phosphorylation in bovine adrenal chomaffin cells', Journal of Neuroscience Methods, 87 167-174 (1999) [C1]
CitationsScopus - 20Web of Science - 20
1998Bobrovskaya L, Cheah TB, Bunn SJ, Dunkley PR, 'Angiotensin II-mediated phosphorylation of tyrosine hydroxylase in bovine adrenal chromaffin cells', JOURNAL OF NEUROCHEMISTRY, 71 S60-S60 (1998)
Author URL
1998Bobrovskaya L, Cheah TB, Bunn SJ, Dunkley PR, 'Tyrosine hydroxylase in bovine adrenal chromaffin cells: Angiotensin II-stimulated activity and phosphorylation of Ser19, Ser31, and Ser40', Journal of Neurochemistry, 70 2565-2573 (1998) [C1]
CitationsScopus - 30Web of Science - 31
1998Graham ME, Dickson PW, Dunkley PR, Von Nagy-Felsobuki EI, 'Characterisation of the phosphorylation of rat tyrosine hydroxylase using electrospray mass spectrometry', Rapid Communications in Mass Spectrometry, 12 746-748 (1998) [C1]
Co-authorsPhil Dickson
1998Graham ME, Dickson P, Dunkley P, Von Nagy-Felsobuki EI, 'Characterization of the Phosphorylation of Rat Tyrosine Hydroxylase using Electrospray Mass Spectrometry', Rapid Communications in Mass Spectrometry, 12 746-748 (1998) [C1]
CitationsWeb of Science - 6
Co-authorsEllak, Phil Dickson
1997Brent PJ, Herd L, Saunders H, Sim ATR, Dunkley PR, 'Protein phosphorylation and calcium uptake into rat forebrain synaptosomes: Modulation by the sigma (F) ligand 1,3-ditolylguanidine.', J.Neurochem, 68 2201-2211 (1997) [C1]
1997Goncalves CA, Hall A, Sim ATR, Bunn SJ, Marley P, Cheah TB, Dunkley PR, 'Tyrosine hydroxylase phosphorylation in digitonin permeabilised bovine adrenal chromaffin cells: The effect of protein kinase and phosphatase inhibitors on Ser-19 and Ser-40 phosphorylation.', J.Neurochem, 69 2387-2396 (1997) [C1]
CitationsScopus - 14Web of Science - 15
1997Brent PJ, Herd L, Saunders H, Sim ATR, Dunkley PR, 'Protein phosphorylation and calcium uptake into rat forebrain synaptosomes: Modulation by the sigma (sigma) ligand, 1,3-ditolylguanidine', JOURNAL OF NEUROCHEMISTRY, 69 S206-S206 (1997)
Author URL
1997Goncalves CA, Hall A, Sim ATR, Bunn SJ, Marley PD, Cheah TB, Dunkley PR, 'Tyrosine hydroxylase phosphorylation in digitonin-permeabilised bovine adrenal chromaffin cells', JOURNAL OF NEUROCHEMISTRY, 69 S207-S207 (1997)
Author URL
1997Warden RA, Noltorp RS, Francis JL, Dunkley PR, OLoughlin EV, 'Vitamin A deficiency exacerbates methotrexate-induced jejunal injury in rats', JOURNAL OF NUTRITION, 127 770-776 (1997)
Author URL
CitationsScopus - 24Web of Science - 24
1997Bunn SJ, Dunkley PR, 'Histamine-stimulated phospholipase C signalling in the adrenal chromaffin cell: Effects on inositol phospholipid metabolism and tyrosine hydroxylase phosphorylation', CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 24 624-631 (1997)
DOI10.1111/j.1440-1681.1997.tb02103.xAuthor URL
CitationsScopus - 10Web of Science - 10
1996Dunkley PR, Cote A, Harrison SM, Herd L, Hall A, Powis DA, 'Tyrosine hydroxylase phosphorylation in bovine adrenal chromaffin cells - Clonidine stimulates basal but inhibits nicotinic receptor evoked phosphorylation', BIOCHEMICAL PHARMACOLOGY, 51 239-245 (1996)
DOI10.1016/0006-2952(95)02128-0Author URL
CitationsScopus - 12Web of Science - 12
1996Warden RA, Strazzari MJ, Dunkley PR, OLoughlin EV, 'Vitamin A-deficient rats have only mild changes in jejunal structure and function', JOURNAL OF NUTRITION, 126 1817-1826 (1996)
Author URL
CitationsScopus - 25Web of Science - 27
1996Powis DA, OBrien KJ, Harrison SM, Jarvie PE, Dunkley PR, 'Mn2+ can substitute for Ca2+ in causing catecholamine secretion but not for increasing tyrosine hydroxylase phosphorylation in bovine adrenal chromaffin cells', CELL CALCIUM, 19 419-429 (1996)
DOI10.1016/S0143-4160(96)90115-3Author URL
CitationsWeb of Science - 14
1996Powis DA, O'Brien KJ, Harrison SM, Jarvie PE, Dunkley PR, 'Mn2+ can substitute for Ca2+ in causing catecholamine secretion but not for increasing tyrosine hydroxylase phosphorylation in bovine adrenal chromaffin cells', Cell Calcium, 19 419-429 (1996)

The ability of the divalent cation manganese (Mn2+) to substitute for calcium (Ca2+) both in triggering catecholamine release and in stimulating catecholamine synthesis, as indicated by an increase in tyrosine hydroxylase (TOH) phosphorylation, has been determined in bovine adrenal medullary chromaffin cells maintained in tissue culture. Mn2+ was found to enter chromaffin cells through pathways activated by nicotinic receptor stimulation and potassium depolarisation, and via the Nai:Cao exchange mechanism in Na+-loaded cells. Like Ca2+, entry of Mn2+ through these pathways triggered immediate catecholamine release and, like Ca2+, maintained quantitatively comparable release at least up to 40 min. Unlike Ca2+, Mn2+ did not stimulate an increase in TOH phosphorylation in intact chromaffin cells, even over a prolonged time course, but Mn2+ did stimulate increased TOH phosphorylation in lysed cell preparations showing that its lack of effect in the intact cells was not due to inhibition of the specific phosphorylation pathway. In lysed cell preparations, Mn2+ stimulated also phosphorylation of a different spectrum of proteins to Ca2+, and of the same proteins to different extents. In particular, P80 (MARCKS protein) was more intensely phosphorylated in the presence of Mn2+ than in the presence of Ca2+. Since TOH phosphorylation always occurs when intracellular Ca2+ is increased, the absence of an increase with Mn2+ indicates that none of its intracellular effects could have occurred as a consequence of Mn2+ mobilisation of intracellular Ca2+. In summary, the data show that Mn2+ is a surrogate for Ca2+ in triggering and maintaining catecholamine release, but does not substitute for Ca2+ in stimulating TOH phosphorylation.

CitationsScopus - 16
1996Brent PJ, Saunders H, Dunkley PR, 'Intrasynaptosomal free calcium levels in rat forebrain synaptosomes: Modulation by sigma (sigma) receptor ligands', NEUROSCIENCE LETTERS, 211 138-142 (1996)
DOI10.1016/0304-3940(96)12711-7Author URL
CitationsScopus - 12Web of Science - 12
1996Lengyel I, Nichol KA, Sim ATR, Bennett MR, Dunkley PR, Rostas JAP, 'Characterization of protein kinase and phosphatase systems in chick ciliary ganglion', NEUROSCIENCE, 70 577-588 (1996)
DOI10.1016/0306-4522(95)00356-8Author URL
CitationsScopus - 8Web of Science - 9
Co-authorsJohn Rostas
1996Amini SA, Dunkley PR, Murdoch RN, 'Teratogenic effects of ethanol in the Quackenbush Special mouse', DRUG AND ALCOHOL DEPENDENCE, 41 61-69 (1996)
DOI10.1016/0376-8716(96)01231-8Author URL
CitationsScopus - 5Web of Science - 5
1996Amini SA, Dunstan RH, Dunkley PR, Murdoch RN, 'Oxidative stress and the fetotoxicity of alcohol consumption during pregnancy', FREE RADICAL BIOLOGY AND MEDICINE, 21 357-365 (1996)
DOI10.1016/0891-5849(96)00027-5Author URL
CitationsScopus - 28Web of Science - 23
Co-authorsHugh Dunstan
1995BRENT PJ, HAYNES H, JARVIE PE, MUDGE L, SIM ATR, DUNKLEY PR, 'PHOSPHORYLATION OF SYNAPSIN I AND DYNAMIN IN RAT FOREBRAIN SYNAPTOSOMES - MODULATION BY SIGMA (SIGMA) LIGANDS', NEUROSCIENCE LETTERS, 191 71-74 (1995)
DOI10.1016/0304-3940(95)11562-1Author URL
CitationsScopus - 8Web of Science - 6
1995SITGES M, DUNKLEY PR, CHIN LM, 'A ROLE FOR CALCIUM/CALMODULIN KINASE(S) IN THE REGULATION OF GABA EXOCYTOSIS', NEUROCHEMICAL RESEARCH, 20 245-252 (1995)
DOI10.1007/BF00969539Author URL
CitationsScopus - 13Web of Science - 10
1995Jarvie PE, Dunkley PR, 'Characterization of calcium/calmodulin-stimulated protein kinase II.', Methods in molecular biology (Clifton, N.J.), 41 239-259 (1995)
CitationsScopus - 15
1995Amini SA, Walsh K, Dunstan R, Dunkley PR, Murdoch RN, 'Maternal hepatic, endometrial, and embryonic levels of Zn, Mg, Cu, and Fe following alcohol consumption during pregnancy in QS mice', RESEARCH COMMUNICATIONS IN ALCOHOL AND SUBSTANCES OF ABUSE, 16 207-219 (1995)
Author URL
CitationsScopus - 1Web of Science - 1
1995WARDEN R, FRANCIS L, DUNKLEY P, OLOUGHLIN E, 'VITAMIN-A-DEFICIENCY POTENTIATES METHOTREXATE (MTX) ENTEROPATHY IN RATS', GASTROENTEROLOGY, 108 A762-A762 (1995)
Author URL
1995BUNN SJ, SIM ATR, HERD LM, AUSTIN LM, DUNKLEY PR, 'TYROSINE-HYDROXYLASE PHOSPHORYLATION IN BOVINE ADRENAL CHROMAFFIN CELLS - THE ROLE OF INTRACELLULAR CA2+ IN THE HISTAMINE H-1 RECEPTOR-STIMULATED PHOSPHORYLATION OF SER(8), SER(19), SER(31), AND SER(40)', JOURNAL OF NEUROCHEMISTRY, 64 1370-1378 (1995)
Author URL
CitationsScopus - 34Web of Science - 36
1995DUNKLEY PR, BUNN SJ, SIM ATR, AUSTIN L, HERD L, HALL A, BUCKENHAM AJ, 'INTRACELLULAR CALCIUM-DEPENDENT PHOSPHORYLATION OF TYROSINE-HYDROXYLASE IN BOVINE ADRENAL CHROMAFFIN CELLS', JOURNAL OF NEUROCHEMISTRY, 65 S5-S5 (1995)
Author URL
1995BRENT PJ, MUDGE L, DUNKLEY PR, 'MODULATION OF PROTEIN-PHOSPHORYLATION BY THE SELECTIVE SIGMA-LIGAND DTG IN RAT CORTICAL SYNAPTOSOMES IS CALCIUM-DEPENDENT AND INHIBITED BY THE SIGMA-ANTAGONIST RIMCAZOLE', JOURNAL OF NEUROCHEMISTRY, 65 S14-S14 (1995)
Author URL
CitationsWeb of Science - 1
1995BUCKENHAM AJ, GONCALVES CA, HALL A, DUNKLEY PR, 'CALCIUM/CALMODULIN-DEPENDENT PROTEIN-KINASE-II IN INTACT BOVINE ADRENAL CHROMAFFIN CELLS', JOURNAL OF NEUROCHEMISTRY, 65 S16-S16 (1995)
Author URL
1995SITGES M, DUNKLEY PR, CHIU LM, 'A ROLE FOR CALCIUM-CALMODULIN KINASE(S) IN THE REGULATION OF GABA EXOCYTOSIS', JOURNAL OF NEUROCHEMISTRY, 65 S19-S19 (1995)
Author URL
1995BUNN SJ, SAUNDERS HI, DUNKLEY PR, 'HISTAMINE-STIMULATED INOSITOL PHOSPHOLIPID-METABOLISM IN BOVINE ADRENAL-MEDULLARY CELLS - A KINETIC-ANALYSIS', JOURNAL OF NEUROCHEMISTRY, 65 626-635 (1995)
Author URL
CitationsScopus - 14Web of Science - 11
1994WARDEN RA, STRAZZARI MJ, DUNKLEY PR, OLOUGHLIN EV, 'THE EFFECT OF VITAMIN-A-DEFICIENCY ON INTESTINAL STRUCTURE AND FUNCTION', GASTROENTEROLOGY, 106 A639-A639 (1994)
Author URL
1993BUNN SJ, BOYD TE, DUNKLEY PR, 'KINETIC-ANALYSIS OF HISTAMINE-STIMULATED INOSITOL PHOSPHOLIPID-METABOLISM IN BOVINE ADRENAL CHROMAFFIN CELLS', JOURNAL OF NEUROCHEMISTRY, 61 S104-S104 (1993)
Author URL
1993SIM ATR, RATCLIFFE E, DUNKLEY PR, ROSTAS JAP, 'MEMBRANE-BOUND FORMS OF PROTEIN PHOSPHATASE TYPE-1 AND TYPE-2A HAVE LOWER ACTIVITY THAN CYTOSOLIC FORMS IN BRAIN', JOURNAL OF NEUROCHEMISTRY, 61 S136-S136 (1993)
Author URL
Co-authorsJohn Rostas
1993BUNN SJ, AUSTIN LM, HERD LM, DUNKLEY PR, 'HISTAMINERGIC PHOSPHORYLATION OF TYROSINE-HYDROXYLASE IN BOVINE ADRENAL CHROMAFFIN CELLS', JOURNAL OF NEUROCHEMISTRY, 61 S153-S153 (1993)
Author URL
1993LENGYEL I, NICHOL KA, BENNETT MR, ROSTAS JAP, DUNKLEY PR, 'PROTEIN-PHOSPHORYLATION IN CHICK CILIARY GANGLION', JOURNAL OF NEUROCHEMISTRY, 61 S221-S221 (1993)
Author URL
Co-authorsJohn Rostas
1993SIM ATR, LLOYD HGE, JARVIE PE, MORRISON M, ROSTAS JAP, DUNKLEY PR, 'SYNAPTOSOMAL AMINO-ACID RELEASE - EFFECT OF INHIBITING PROTEIN PHOSPHATASES WITH OKADAIC ACID', NEUROSCIENCE LETTERS, 160 181-184 (1993)
DOI10.1016/0304-3940(93)90408-DAuthor URL
CitationsScopus - 17Web of Science - 19
Co-authorsJohn Rostas
1992KIDD GJ, HEATH JW, TRAPP BD, DUNKLEY PR, 'MYELIN SHEATH SURVIVAL AFTER GUANETHIDINE-INDUCED AXONAL DEGENERATION', JOURNAL OF CELL BIOLOGY, 116 395-403 (1992)
DOI10.1083/jcb.116.2.395Author URL
CitationsScopus - 2Web of Science - 5
1992BUNN SJ, HARRISON SM, DUNKLEY PR, 'PROTEIN-PHOSPHORYLATION IN BOVINE ADRENAL-MEDULLARY CHROMAFFIN CELLS - HISTAMINE-STIMULATED PHOSPHORYLATION OF TYROSINE-HYDROXYLASE', JOURNAL OF NEUROCHEMISTRY, 59 164-174 (1992)
DOI10.1111/j.1471-4159.1992.tb08887.xAuthor URL
CitationsScopus - 17Web of Science - 18
1992ROSTAS JAP, DUNKLEY PR, 'MULTIPLE FORMS AND DISTRIBUTION OF CALCIUM/CALMODULIN-STIMULATED PROTEIN KINASE-II IN BRAIN', JOURNAL OF NEUROCHEMISTRY, 59 1191-1202 (1992)
DOI10.1111/j.1471-4159.1992.tb08428.xAuthor URL
CitationsScopus - 40Web of Science - 49
Co-authorsJohn Rostas
1992PRESEK P, JESSEN S, DREYER F, JARVIE PE, FINDIK D, DUNKLEY PR, 'TETANUS TOXIN INHIBITS DEPOLARIZATION-STIMULATED PROTEIN-PHOSPHORYLATION IN RAT CORTICAL SYNAPTOSOMES - EFFECT ON SYNAPSIN-I PHOSPHORYLATION AND TRANSLOCATION', JOURNAL OF NEUROCHEMISTRY, 59 1336-1343 (1992)
DOI10.1111/j.1471-4159.1992.tb08445.xAuthor URL
CitationsScopus - 21Web of Science - 20
1992CAMPBELL EM, REDMAN S, DUNKLEY PR, MOFFITT PS, 'THE USE OF PORTABLE BLOOD-GLUCOSE MONITORS BY TRAINED LAY OPERATORS', MEDICAL JOURNAL OF AUSTRALIA, 157 446-448 (1992)
Author URL
CitationsScopus - 3Web of Science - 3
1991BUNN SJ, DUNKLEY PR, 'OPIOID INHIBITION OF NICOTINE-INDUCED CA-45(2+)-UPTAKE INTO CULTURED BOVINE ADRENAL-MEDULLARY CELLS', BIOCHEMICAL PHARMACOLOGY, 41 715-722 (1991)
DOI10.1016/0006-2952(91)90071-CAuthor URL
CitationsScopus - 11Web of Science - 15
1991Thorne B, Wonnacott S, Dunkley PR, 'Isolation of hippocampal synaptosomes on percoll gradients: Cholinergic markers and ligand binding sites', Journal of Neurochemistry, 56 479-484 (1991)

The S1 Percoll procedure, devised empirically for cortical tissue, provides highly purified, functionally viable synaptosomes on a four-step Percoll gradient. Here, for the first time, the procedure has been applied to rat hippocampus, and the gradient fractions have been analysed with respect to cholinergic markers and the synaptosomal index, lactate dehydrogenase. The presynaptic cholinergic markers choline acetyltransferase and [3H]choline uptake were most enriched in fraction 4. In contrast, acetylcholinesterase activity was broadly distributed across the gradient, consistent with the separation of synaptic plasma membranes (in fractions 1 and 2) from synaptosomes (in fractions 3 and 4). This is supported by the recovery of muscarinic binding sites labelled with [3H]quinuclidinylbenzilate in fractions 1 and 2. (-)-[3H]-Nicotine binding sites, however, were most enriched in fraction 4, consistent with their predominantly presynaptic localisation in the CNS. These results demonstrate the applicability of the S1 Percoll method to discrete brain regions for the recovery of homogeneous and viable synaptosome fractions. The separation of presynaptic terminals from postsynaptic membranes is a further advantage of this technique.

CitationsScopus - 18
1991KIDD GJ, HEATH JW, TRAPP BD, LITTLE GJ, DUNKLEY PR, 'MYELIN SHEATH MAINTENANCE IN THE ABSENCE OF AXONS', ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 633 549-549 (1991)
Author URL
1991SIM ATR, DUNKLEY PR, JARVIE PE, ROSTAS JAP, 'MODULATION OF SYNAPTOSOMAL PROTEIN-PHOSPHORYLATION DEPHOSPHORYLATION BY CALCIUM IS ANTAGONIZED BY INHIBITION OF PROTEIN PHOSPHATASES WITH OKADAIC ACID', NEUROSCIENCE LETTERS, 126 203-206 (1991)
DOI10.1016/0304-3940(91)90554-7Author URL
CitationsScopus - 19Web of Science - 29
Co-authorsJohn Rostas
1991HEATH JW, KIDD GJ, TRAPP BD, DUNKLEY PR, 'MYELIN MAINTENANCE BY SCHWANN-CELLS IN THE ABSENCE OF AXONS', NEUROSCIENCE LETTERS, 128 277-280 (1991)
DOI10.1016/0304-3940(91)90279-3Author URL
CitationsScopus - 2Web of Science - 6
1991JEITNER TM, JARVIE PE, COSTA M, ROSTAS JAP, DUNKLEY PR, 'PROTEIN-PHOSPHORYLATION IN GUINEA-PIG MYENTERIC GANGLIA AND BRAIN - PRESENCE OF CALMODULIN KINASE-II, PROTEIN-KINASE-C AND CYCLIC-AMP KINASE AND CHARACTERIZATION OF MAJOR PHOSPHOPROTEINS', NEUROSCIENCE, 40 555-569 (1991)
DOI10.1016/0306-4522(91)90141-AAuthor URL
CitationsScopus - 8Web of Science - 14
Co-authorsJohn Rostas
1991DUNKLEY PR, 'AUTOPHOSPHORYLATION OF NEURONAL CALCIUM CALMODULIN-STIMULATED PROTEIN KINASE-II', MOLECULAR NEUROBIOLOGY, 5 179-202 (1991)
DOI10.1007/BF02935545Author URL
CitationsScopus - 16Web of Science - 11
1991DUNKLEY PR, COTE A, HARRISON SM, 'AUTOPHOSPHORYLATION OF CALMODULIN-STIMULATED PROTEIN KINASE-II IN INTACT SYNAPTOSOMES', JOURNAL OF MOLECULAR NEUROSCIENCE, 2 193-201 (1991)
Author URL
CitationsScopus - 2Web of Science - 6
1989O'Dea K, Dunkley P, MacMahon B, Seal J, Birkbeck J, Court J, et al., 'Methods and models for introducing nutrition into the medical curriculum', Medical Journal of Australia, 151 (1989)
1989ROSTAS JAP, BRENT VA, SECCOMBE M, WEINBERGER RP, DUNKLEY PR, 'PURIFICATION AND CHARACTERIZATION OF CALMODULIN-STIMULATED PROTEIN KINASE-II FROM 2-DAY AND ADULT CHICKEN FOREBRAIN', JOURNAL OF MOLECULAR NEUROSCIENCE, 1 93-104 (1989)
DOI10.1007/BF02918895Author URL
CitationsScopus - 5Web of Science - 10
Co-authorsJohn Rostas
1989Rostas JAP, Brent VA, Seccombe M, Weinberger RP, Dunkley PR, 'Purification and characterization of calmodulin-stimulated protein kinase II from two-day and adult chicken forebrain', Journal of Molecular Neuroscience, 1 93-104 (1989)

Soluble calmodulin-stimulated protein kinase II has been purified from 2-day and adult chicken forebrain At both ages the holoenzyme eluted from a Superose-6B column with an apparent molecular weight of approximately 700,000 daltons and contained three subunits. The subunits were found to be the counterparts of the alpha, beta, and betá subunits of the enzyme purified from adult rat brain in that they had one-dimensional phosphopeptide maps that were indistinguishable from those of the corresponding subunit in the rat enzyme and they migrated in SDS-polyacrylamide gels with the same apparent molecular weights. However, the doublet formed by the beta subunit was much more clearly resolved in the chicken enzyme and the betá subunit, which was much more abundant in the adult chicken than in the adult rat, was also found to be a doublet. The ratio of the concentrations of the alpha and beta subunits changed during development. By autoradiography following autophosphorylation, the alpha:beta ratios of the 2-day and adult enzymes were 0.89±0.07 and 1.92±0.26, reapectively; by silver staining the alpha:beta ratios were 0.95±0.11 and 1.85±0.17, respectively. The concentration of the betá subunit was equal to that of the beta subunit at both ages. Autophosphorylation produced a decrease in the electrophoretic mobility of the alpha and beta subunits in SDS-polyacrylamide gels and a marked decrease in the calcium dependence of the substrate phosphorylation activity of the enzyme at both ages. The purified enzyme from chicken brain appeared to be more stable under standard in vitro assay conditions than the rat enzyme, and this was particularly so for the enzyme from 2-day forebrain. © 1989 Humana Press Inc.

DOI10.1007/BF02918895
Co-authorsJohn Rostas
1988DUNKLEY PR, HEATH JW, HARRISON SM, JARVIE PE, GLENFIELD PJ, ROSTAS JAP, 'A RAPID PERCOLL GRADIENT PROCEDURE FOR ISOLATION OF SYNAPTOSOMES DIRECTLY FROM AN S-1 FRACTION - HOMOGENEITY AND MORPHOLOGY OF SUBCELLULAR-FRACTIONS', BRAIN RESEARCH, 441 59-71 (1988)
DOI10.1016/0006-8993(88)91383-2Author URL
CitationsScopus - 274Web of Science - 315
Co-authorsJohn Rostas
1988HARRISON SM, JARVIE PE, DUNKLEY PR, 'A RAPID PERCOLL GRADIENT PROCEDURE FOR ISOLATION OF SYNAPTOSOMES DIRECTLY FROM AN S-1 FRACTION - VIABILITY OF SUBCELLULAR-FRACTIONS', BRAIN RESEARCH, 441 72-80 (1988)
DOI10.1016/0006-8993(88)91384-4Author URL
CitationsScopus - 29Web of Science - 38
1988DUNKLEY PR, JARVIE PE, ROSTAS JAP, 'DISTRIBUTION OF CALMODULIN-STIMULATED AND CYCLIC AMP-STIMULATED PROTEIN-KINASES IN SYNAPTOSOMES', JOURNAL OF NEUROCHEMISTRY, 51 57-68 (1988)
DOI10.1111/j.1471-4159.1988.tb04835.xAuthor URL
CitationsScopus - 7Web of Science - 20
Co-authorsJohn Rostas
1988THORNE B, IRONS J, LUNT GG, WONNACOTT S, DUNKLEY PR, 'COMPARISON OF METHODS FOR RAPID ISOLATION OF SYNAPTOSOMES FROM BRAIN-REGIONS, FOR UPTAKE AND RELEASE STUDIES', BIOCHEMICAL SOCIETY TRANSACTIONS, 16 309-310 (1988)
Author URL
CitationsWeb of Science - 8
1987ROBINSON PJ, DUNKLEY PR, 'ALTERED PROTEIN-PHOSPHORYLATION IN INTACT RAT CORTICAL SYNAPTOSOMES AFTER INVIVO ADMINISTRATION OF FLUPHENAZINE', BIOCHEMICAL PHARMACOLOGY, 36 2203-2208 (1987)
DOI10.1016/0006-2952(87)90151-1Author URL
CitationsScopus - 2Web of Science - 2
1987ROBINSON PJ, HAUPTSCHEIN R, LOVENBERG W, DUNKLEY PR, 'DEPHOSPHORYLATION OF SYNAPTOSOMAL PROTEINS P96 AND P139 IS REGULATED BY BOTH DEPOLARIZATION AND CALCIUM, BUT NOT BY A RISE IN CYTOSOLIC CALCIUM ALONE', JOURNAL OF NEUROCHEMISTRY, 48 187-195 (1987)
DOI10.1111/j.1471-4159.1987.tb13146.xAuthor URL
CitationsWeb of Science - 46
1987Rostas JAP, Brent V, Dunkley PR, 'The effect of calmodulin and autophosphorylation on the activity of calmodulin-stimulated protein kinase II', Neuroscience Research Communications, 1 3-8 (1987)
CitationsScopus - 2
Co-authorsJohn Rostas
1986DUNKLEY PR, JARVIE PE, HEATH JW, KIDD GJ, ROSTAS JAP, 'A RAPID METHOD FOR ISOLATION OF SYNAPTOSOMES ON PERCOLL GRADIENTS', BRAIN RESEARCH, 372 115-129 (1986)
DOI10.1016/0006-8993(86)91464-2Author URL
CitationsScopus - 272Web of Science - 366
Co-authorsJohn Rostas
1986KIDD GJ, HEATH JW, DUNKLEY PR, 'SELECTIVE DEGENERATION OF MYELINATED SYMPATHETIC-NERVES FOLLOWING TREATMENT WITH GUANETHIDINE', JOURNAL OF ANATOMY, 149 250-250 (1986)
Author URL
1986DUNKLEY PR, BAKER CM, ROBINSON PJ, 'DEPOLARIZATION-DEPENDENT PROTEIN-PHOSPHORYLATION IN RAT CORTICAL SYNAPTOSOMES - CHARACTERIZATION OF ACTIVE PROTEIN-KINASES BY PHOSPHOPEPTIDE ANALYSIS OF SUBSTRATES', JOURNAL OF NEUROCHEMISTRY, 46 1692-1703 (1986)
Author URL
CitationsScopus - 29Web of Science - 60
1986DUNKLEY PR, ROBINSON PJ, 'DEPOLARIZATION-DEPENDENT PROTEIN-PHOSPHORYLATION IN SYNAPTOSOMES - MECHANISMS AND SIGNIFICANCE', PROGRESS IN BRAIN RESEARCH, 69 273-293 (1986)
DOI10.1016/S0079-6123(08)61065-1Author URL
CitationsScopus - 25Web of Science - 60
1986ROSTAS JAP, WEINBERGER RP, DUNKLEY PR, 'MULTIPLE POOLS AND MULTIPLE FORMS OF CALMODULIN-STIMULATED PROTEIN-KINASE DURING DEVELOPMENT - RELATIONSHIP TO POSTSYNAPTIC DENSITIES', PROGRESS IN BRAIN RESEARCH, 69 355-371 (1986)
DOI10.1016/S0079-6123(08)61070-5Author URL
CitationsScopus - 10Web of Science - 26
Co-authorsJohn Rostas
1986KIDD GJ, HEATH JW, DUNKLEY PR, 'DEGENERATION OF MYELINATED SYMPATHETIC-NERVE FIBERS FOLLOWING TREATMENT WITH GUANETHIDINE', JOURNAL OF NEUROCYTOLOGY, 15 561-572 (1986)
DOI10.1007/BF01611857Author URL
CitationsScopus - 4Web of Science - 13
1986ROSTAS JAP, BRENT VA, HEATH JW, NEAME RLB, POWIS DA, WEINBERGER RP, DUNKLEY PR, 'THE SUBCELLULAR-DISTRIBUTION OF A MEMBRANE-BOUND CALMODULIN-STIMULATED PROTEIN-KINASE', NEUROCHEMICAL RESEARCH, 11 253-268 (1986)
DOI10.1007/BF00967973Author URL
CitationsScopus - 11Web of Science - 23
Co-authorsJohn Rostas
1985ROBINSON PJ, DUNKLEY PR, 'DEPOLARIZATION-DEPENDENT PROTEIN-PHOSPHORYLATION AND DEPHOSPHORYLATION IN RAT CORTICAL SYNAPTOSOMES IS MODULATED BY CALCIUM', JOURNAL OF NEUROCHEMISTRY, 44 338-348 (1985)
DOI10.1111/j.1471-4159.1985.tb05422.xAuthor URL
CitationsScopus - 36Web of Science - 65
1984ROBINSON PJ, JARVIE PE, DUNKLEY PR, 'DEPOLARIZATION-DEPENDENT PROTEIN-PHOSPHORYLATION IN RAT CORTICAL SYNAPTOSOMES IS INHIBITED BY FLUPHENAZINE AT A STEP AFTER CALCIUM ENTRY', JOURNAL OF NEUROCHEMISTRY, 43 659-667 (1984)
DOI10.1111/j.1471-4159.1984.tb12785.xAuthor URL
CitationsScopus - 11Web of Science - 21
1984NELL JA, DUNKLEY PR, 'EFFECTS OF TEMPERATURE, NUTRITIONAL FACTORS AND SALINITY ON THE UPTAKE OF L-METHIONINE BY THE SYDNEY ROCK OYSTER SACCOSTREA-COMMERCIALIS', MARINE BIOLOGY, 80 335-339 (1984)
DOI10.1007/BF00392829Author URL
CitationsScopus - 8Web of Science - 11
1984ROBINSON PJ, DUNKLEY PR, 'IS THERE A ROLE FOR CALCIUM-STIMULATED PROTEIN-PHOSPHORYLATION IN NEUROTRANSMITTER RELEASE', PROCEEDINGS OF THE AUSTRALIAN BIOCHEMICAL SOCIETY, 16 S40-S40 (1984)
Author URL
1984WEINBERGER RP, DUNKLEY PR, ROSTAS JAP, 'DEVELOPMENTAL ACCUMULATION OF A CALMODULIN STIMULATED PROTEIN-KINASE IN SYNAPTIC-MEMBRANES', PROCEEDINGS OF THE AUSTRALIAN BIOCHEMICAL SOCIETY, 16 87-87 (1984)
Author URL
CitationsWeb of Science - 1
Co-authorsJohn Rostas
1983ROBINSON PJ, DUNKLEY PR, 'DEPOLARIZATION-DEPENDENT PROTEIN-PHOSPHORYLATION IN RAT CORTICAL SYNAPTOSOMES - FACTORS DETERMINING THE MAGNITUDE OF THE RESPONSE', JOURNAL OF NEUROCHEMISTRY, 41 909-918 (1983)
DOI10.1111/j.1471-4159.1983.tb09034.xAuthor URL
CitationsScopus - 43Web of Science - 84
1983NELL JA, SKEEL ME, DUNKLEY P, 'UPTAKE OF SOME DISSOLVED ORGANIC NUTRIENTS BY THE SYDNEY ROCK OYSTER SACCOSTREA-COMMERCIALIS', MARINE BIOLOGY, 74 313-318 (1983)
DOI10.1007/BF00403457Author URL
CitationsScopus - 8Web of Science - 8
1983ROBINSON PJ, DUNKLEY PR, 'DEPOLARIZATION-DEPENDENT PROTEIN-PHOSPHORYLATION IN RAT CORTICAL SYNAPTOSOMES - THE EFFECTS OF CALCIUM, STRONTIUM AND BARIUM', NEUROSCIENCE LETTERS, 43 85-90 (1983)
DOI10.1016/0304-3940(83)90133-7Author URL
CitationsScopus - 19Web of Science - 32
1983ROSTAS JAP, BRENT VA, DUNKLEY PR, 'THE MAJOR CALMODULIN-STIMULATED PHOSPHOPROTEIN OF SYNAPTIC JUNCTIONS AND THE MAJOR POST-SYNAPTIC DENSITY PROTEIN ARE DISTINCT', NEUROSCIENCE LETTERS, 43 161-165 (1983)
DOI10.1016/0304-3940(83)90181-7Author URL
CitationsScopus - 5Web of Science - 18
Co-authorsJohn Rostas
1983DUNKLEY PR, ROBINSON PJ, 'THE INVITRO PHOSPHORYLATION OF ACTIN FROM RAT CEREBRAL-CORTEX', NEUROCHEMICAL RESEARCH, 8 865-871 (1983)
DOI10.1007/BF00964547Author URL
CitationsScopus - 5Web of Science - 13
1981DUNKLEY PR, ROBINSON PJ, 'CALCIUM-STIMULATED PROTEIN-KINASES FROM RAT CEREBRAL-CORTEX ARE INACTIVATED BY PRE-INCUBATION', BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 102 1196-1202 (1981)
DOI10.1016/S0006-291X(81)80138-6Author URL
CitationsScopus - 8Web of Science - 25
1981DUNKLEY PR, ROBINSON PJ, 'PREINCUBATION OF SUB-CELLULAR FRACTIONS FROM RAT CEREBRAL-CORTEX INACTIVATES PROTEIN-PHOSPHORYLATION', BIOCHEMICAL JOURNAL, 199 269-272 (1981)
Author URL
CitationsWeb of Science - 13
1980DUNKLEY PR, 'IS PROTEIN-PHOSPHORYLATION INVOLVED IN NEUROTRANSMISSION IN THE CENTRAL NERVOUS-SYSTEM', PROCEEDINGS OF THE AUSTRALIAN BIOCHEMICAL SOCIETY, 13 Q5-Q5 (1980)
Author URL
1980DUNKLEY PR, 'PHOSPHORYLATION OF SYNAPTOSOMAL PROTEINS INVITRO - THE EFFECT OF HYPOTONIC LYSIS AND TRITON X-100', PROCEEDINGS OF THE AUSTRALIAN BIOCHEMICAL SOCIETY, 13 118-118 (1980)
Author URL
Show 140 more journal articles

Conference (45 outputs)

YearCitationAltmetricsLink
2014Ong LK, Briggs GD, Dunkley PR, Dickson PW, 'The role of inflammation and dopamine synthesis in Parkinson's disease', JOURNAL OF NEUROCHEMISTRY, Kaohsiung, TAIWAN (2014) [E3]
Author URL
Co-authorsPhil Dickson, Linkooi Ong
2013Guan L, Werno M, Gordon SL, Dunkley P, Dickson PW, 'The effect of tyrosine hydroxylase on alpha-synuclein aggregation', JOURNAL OF NEUROCHEMISTRY, Cancun, MEXICO (2013) [E3]
Author URL
Co-authorsPhil Dickson
2013Dickson P, Shehadeh J, Double K, Bobrovskaya L, Reyes S, Dunkley P, Halliday G, 'Analysis of Tyrosine Hydroxylase Isoforms and Phosphorylation in Parkinson's Disease' (2013) [E3]
DOI10.1016/B978-0-12-800044-1.00011-8
2012Sominsky Bar L, Fuller AE, Bondarenko E, Ong LK, Clark VR, Bobrovskaya L, et al., 'Neonatal programming of the autonomic nervous system by immunological challenge: Implications for anxiety', Abstracts of the 21st Annual Meeting of the International Behavioral Neuroscience Society, Kona, Hawaii (2012) [E3]
Co-authorsEugene Nalivaiko, Linkooi Ong, Deborah Hodgson
2012Guan L, Werno M, Gordon SL, Dunkley PR, Dickson PW, 'Effect of tyrosine hydroxylase on alphasynuclein aggregation', Abstracts. Australian Neuroscience Society 32nd Annual Meeting, Gold Coast, Queensland (2012) [E3]
Co-authorsPhil Dickson
2012James MH, Charnley JL, Levi EM, Dunkley PR, Smith DW, Dickson PW, Dayas CV, 'A role for the mTOR pathway in the development of addiction', Abstracts. Australian Neuroscience Society 32nd Annual Meeting, Gold Coast, Queensland (2012) [E3]
Co-authorsDouglas Smith, Phil Dickson, Christopher Dayas
2012Ong LK, Guan L, Bobrovskaya L, Dickson PW, Dunkley PR, 'Neurobiological consequences of acute footshock stress', Journal of Neurochemistry, Kobe, Japan (2012) [E3]
Co-authorsLinkooi Ong, Phil Dickson
2012Sominsky Bar L, Fuller EA, Bondarenko E, Ong LK, Clark VR, Bobrovskaya L, et al., 'Neonatal immune challenge induces anxiety in adulthood and is associated with functional alterations to the autonomic nervous system', Brain, Behavior, and Immunity, San Diego, CA (2012) [E3]
Co-authorsDeborah Hodgson, Eugene Nalivaiko, Linkooi Ong
2011Barreto RDA, Walker FR, Dunkley PR, Day TA, Smith DW, 'Alteration of neurotrophic factor pathway gene expression in the rat infralimbic medial prefrontal cortex by subchronic restraint stress is reversed by fluoxetine', Posters. Australian Neuroscience Society 31st Annual Meeting, Auckland, New Zealand (2011) [E3]
Co-authorsRohan Walker, Douglas Smith, Trevor Day
2011Damanhuri H, Bobrovskaya L, Dunkley P, Goodchild A, 'Effect of barodenervation on tyrosine hydroxylase phosphorylation in rat brain following hypotension', FASEB JOURNAL, Washington, DC (2011) [E3]
Author URL
2010Damanhuri H, Bobrovskaya L, Dunkley PR, Goodchild AK, 'Effect of glucoprivation and hypotension on tyrosine hydroxylase phosphorylation in different catecholmine cell groups in the rat brainstem', Journal of Neurochemistry, Phuket, Thailand (2010) [E3]
2010Ong LK, Guan L, Stutz B, Dickson PW, Dunkley PR, Bobrovskaya L, 'Tyrosine hydroxylase phosphorylation in response to footshock and restraint stress', Journal of Neurochemistry, Phuket, Thailand (2010) [E3]
DOI10.1093/jac/dkq221
CitationsScopus - 1
Co-authorsPhil Dickson, Linkooi Ong
2009Bobrovskaya L, Damanhuri H, Ong LK, Dickson PW, Dunkley PR, Goodchild AK, 'The effect of glucoprivation on tyrosine hydroxylase phosphorylation in adrenals of Sprague-Dawley rats', Autonomic Neuroscience: Basic and Clinical, Sydney, NSW (2009) [E3]
DOI10.1016/j.autneu.2009.05.191
Co-authorsLinkooi Ong, Phil Dickson
2009Damanhuri H, Ong LK, Bobrovskaya L, Dunkley PR, Goodchild AK, 'Activation of tyrosine hydroxylase in the A8, A9 and A10 cell groups following hypotension and glucoprivation in Sprague Dawley rat', Autonomic Neuroscience: Basic and Clinical, Sydney, NSW (2009) [E3]
DOI10.1016/j.autneu.2009.05.228
Co-authorsLinkooi Ong
2009Ong LK, Maniam J, Dunkley PR, Bobrovskaya L, Morris MJ, 'The effect of voluntary exercise and high fat diet on tyrosine hydroxylase phosphorylation in male Sprague-Dawley rats exposed to early life stress', Autonomic Neuroscience: Basic and Clinical, Sydney, NSW (2009) [E3]
DOI10.1016/j.autneu.2009.05.192
Co-authorsLinkooi Ong
2009Bobrovskaya L, Ong LK, Walker RA, Day TA, Dickson PW, Dunkley PR, 'The effect of social stress on tyrosine hydroxylase phosphorylation', ANS 2009 Abstracts: Posters, Canberra, ACT (2009) [E3]
Co-authorsLinkooi Ong, Phil Dickson, Trevor Day
2009Gordon SL, Dunkley PR, Dickson PW, 'The low affinity dopamine binding site regulates tyrosine hydroxylase activity in situ: Implications for the regulation of cytosolic catecholamine levels', ANS 2009 Abstracts: Posters, Canberra, ACT (2009) [E3]
Co-authorsPhil Dickson
2009Briggs GD, Gordon SL, Dunkley PR, Dickson PW, 'Localisation of the low affinity catecholamine binding site in tyrosine hydroxylase', ANS 2009 Abstracts: Posters, Canberra, ACT (2009) [E3]
Co-authorsPhil Dickson
2009Gordon SL, Bobrovskaya L, Dunkley PR, Dickson PW, 'Differential regulation of the two major isoforms of human tyrosine hydroxylase in situ', Journal of Neurochemistry, Busan, Korea (2009) [E3]
DOI10.1111/j.1471-4159.2009.06242.x
Co-authorsPhil Dickson
2009Ong LK, Bobrovskaya L, Walker FR, Day TA, Dickson PW, Dunkley PR, 'The effect of social conflict on tyrosine hydroxylase phosphorylation in catecholamine-producing cells from sprague-dawley rats', Journal of Neurochemistry, Busan, Korea (2009) [E3]
DOI10.1111/j.1471-4159.2009.06242.x
Co-authorsRohan Walker, Phil Dickson, Linkooi Ong, Trevor Day
2009Dickson PW, Shehadeh J, Double KL, Bobrovskaya L, Reyes S, Dunkley PR, Halliday GM, 'Distribution of tyrosine hydroxylase isoforms in the human brain', Journal of Neurochemistry, Busan, Korea (2009) [E3]
DOI10.1111/j.1471-4159.2009.06239.x
Co-authorsPhil Dickson
2009Shehadeh J, Double K, Murphy K, Bobrovskaya L, Reyes S, Dunkley PR, et al., 'Differential distribution of tyrosine hydroxylase isoforms in the human brain', Parkinsonism & Related Disorders, Miami Beach, FL (2009) [E3]
Co-authorsPhil Dickson
2008Gelain DP, Mareira JC, Bevilaqua LRM, Dickson PW, Dunkley PR, 'Retinol stimulates tyrosine hydroxylase activity by increasing ser40 phosphorylation in bovine adrenal chromaffin cells', Proceedings of the Australian Neuroscience Society, Hobart, TAS (2008) [E3]
Co-authorsPhil Dickson
2008Lonergan T, Bobrovskaya L, Dunkley PR, Dickson PW, Pilowsky PM, Goodchild A, 'Intracellular signaling pathways in catecholaminergic cells activitated by glucoprivation', Proceedings of the Australian Neuroscience Society, Hobart, TAS (2008) [E3]
Co-authorsPhil Dickson
2008Posser T, Franco JL, Bobrovskaya L, Leal RB, Dickson PW, Dunkley PR, 'Sustained tyrosine hydroxylase phosphorylation in pc12 cells exposed to manganese', Proceedings of the Australian Neuroscience Society, Hobart, TAS (2008) [E3]
Co-authorsPhil Dickson
2008Gelain DP, Moreira JC, Bevilaqua LRM, Dickson PW, Dunkley PR, 'Retinol stimulates tyrosine hydroxylase activity by increasing ser40 and then ser 31 phosphorylation in bovine adrenal chromaffin cells', Journal of Neurochemistry, Shanghai, China (2008) [E3]
Co-authorsPhil Dickson
2007Bobrovskaya L, Gelain D, Gilligan C, Flaherty J, Bolster EK, Dickson PW, Dunkley PR, 'Nicotine and Pacap stimulate the sustained phosphorylation of tyrosine hydroxylase at serine 40 (Poster)', 7th IBRO 2007 World Congress of Neuroscience Program, Melbourne (2007) [E3]
Co-authorsPhil Dickson, Conor Gilligan
2007Gordon SL, Quinsey NS, Dunkley PR, Dickson PW, 'Tyrosine hydroxylase activity is regulated by two distinct dopamine binding sites (Poster)', 7th IBRO 2007 World Congress of Neuroscience Program, Melbourne (2007) [E3]
Co-authorsPhil Dickson
2007Gelain DP, Moreira JC, Bevilaqua LR, Dickson PW, Dunkley PR, 'Retinol stimulates tyrosine hydroxylase activity by increasing Ser40 phosphorylation in bovine adrenal chromaffin cells', JOURNAL OF NEUROCHEMISTRY, Cancun, MEXICO (2007)
Author URL
Co-authorsPhil Dickson
2006Dunkley PR, 'Sustained phosphorylation of tyrosine hydroxylase at serine 40: a novel mechanism for maintenance of catecholamine synthesis', Journal of Neurochemistry, Singapore (2006) [E3]
2006Dunkley PR, Bobrovskaya L, Gilligan C, Bolster EK, Flaherty J, Dickson PW, 'Sustained phosphorylation of tyrosine hydroxylase at serine 40 is inhibited by the antidepressant imipramine', Proceedings of the Australian Neuroscience Society, Sydney, NSW (2006) [E3]
Co-authorsPhil Dickson, Conor Gilligan
2006Lehmann IT, Bobrovskaya L, Dunkley PR, Dickson PW, 'Differential regulation of the human tyrosine hydroxylase isoforms via hierarchical phosphorylation', Proceedings of the Australian Neuroscience Society, Sydney (2006) [E3]
Co-authorsPhil Dickson
2005Dunkley PR, Bobrovskaya L, Gilligan C, Soster E, Dickson PW, 'Sustained phosphorylation of tyrosine hydroxylase at Ser40', JOURNAL OF NEUROCHEMISTRY, Innsbruck, AUSTRIA (2005) [E1]
Author URL
Co-authorsConor Gilligan, Phil Dickson
2005Lehmann IT, Bobrovskaya L, Dunkley PR, Dickson PW, 'Phosphorylation of Ser31 increases the activation of tyrosine hydroxylase via hierarchical phosphorylation', JOURNAL OF NEUROCHEMISTRY, Innsbruck, AUSTRIA (2005) [E1]
Author URL
Co-authorsPhil Dickson
2004Bobrovskaya L, Dunkley PR, Dickson PW, 'Phosphorylation of Ser19 increases both Ser40 phosphorylation and enzyme activity of tyrosine hydroxylase in intact cells', Journal of Neurochemistry, England (2004) [E1]
DOI10.1111/j.1471-4159.2004.02550.x
CitationsScopus - 40Web of Science - 41
Co-authorsPhil Dickson
2004Bobrovskaya L, Bolster EK, Dickson PW, Dunkley PR, 'Angiotensin II-Stimulated phosphorylation of tyrosine hydroxylase in bovine adrenal chromaffin cells: The role of PKC isozymes', Proceedings of the Australian Neuroscience Society, Melbourne, Australia (2004) [E3]
Co-authorsPhil Dickson
2004Cechin SR, Jacques-Silva MC, Dunkley PR, Rodnight RB, 'Involvement of RhoA pathway and the Na+/H+ exchanger in the LPA-induced proliferation of the C6 glioma cells', Journal of Neurochemistry, Hong Kong (2004) [E3]
2004Dunkley PR, Bobrovskaya L, Dickson PW, Rose J, Lehmann IT, 'Hierarchical phosphorylation of tyrosine hydroxylase in bovine adrenal chromaffin cells', Journal of Neurochemistry, Hong Kong (2004) [E3]
Co-authorsPhil Dickson
2003Bobrovskaya L, Dickson PW, Dunkley PR, 'Hierarchical Phosphorylation of SER19 and SER40 on Tyrosine Hydroxylase in Bovine Adrenal Chromaffin Cells', Proccedings of the Australian Neuroscience Society, Adelaide, Australia (2003) [E3]
Co-authorsPhil Dickson
2003Bobrovskaya L, Dunkley PR, Dickson PW, 'Phosphorylation of Ser19 increases both Ser40 phosphorylation and enzyme activity of tyrosine hydroxylase in intact cells', JOURNAL OF NEUROCHEMISTRY, WANCHAI, PEOPLES R CHINA (2003) [E1]
Author URL
Co-authorsPhil Dickson
2001Graham ME, Dickson PW, Dunkley PR, Von Nagy-Felsobuki EI, 'Quantification of phosphorylation levels of tyrosine hydroxylase utilkizing protein cleavage and electrospray mass spectrometry', Advances in Mass Spectrometry, Barcelona, Spain (2001) [E3]
Co-authorsPhil Dickson, Ellak
2001Bobrovskaya L, Odell A, Dunkley PR, 'Tyrosine hydroxylase phosphorylation in bovine adrenal chromaffin cells: the involvement of MAPKs after angiotensin II stimulation', JOURNAL OF NEUROCHEMISTRY (2001) [E3]
Author URL
CitationsScopus - 30
1996Warden RA, Noltorp RS, Bell CJ, Dunkley PR, OLoughlin EV, 'Intestinal permeability in vitamin A deficient rats', PROCEEDINGS OF THE NUTRITION SOCIETY OF AUSTRALIA, VOL 20, SYDNEY, AUSTRALIA (1996)
Author URL
1996Warden RA, Noltorp R, Francis L, Dunkley PR, OLoughlin EV, 'Vitamin A deficiency potentiates methotrexate-induced enteropathy', EUROPEAN JOURNAL OF CLINICAL NUTRITION, MIJDRECHT, NETHERLANDS (1996)
Author URL
CitationsScopus - 1
1994WARDEN RA, STRAZZARI MJ, DUNKLEY PR, OLOUGHLIN EV, 'Vitamin A deficiency and gastrointestinal structure and function', PROCEEDINGS OF THE NUTRITION SOCIETY OF AUSTRALIA, VOL 18, NEWCASTLE, AUSTRALIA (1994)
Author URL
Show 42 more conferences
Edit

Grants and Funding

Summary

Number of grants73
Total funding$8,348,345

Click on a grant title below to expand the full details for that specific grant.


20141 grants / $185,679

Role of infection in the development of Parkinson's Disease $185,679

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamAssociate Professor Phillip Dickson, Emeritus Professor Peter Dunkley
SchemeProject Grant
RoleInvestigator
Funding Start2014
Funding Finish2014
GNoG1301295
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

20121 grants / $354,601

Human tyrosine hydroxylase isoforms and susceptibility of dopaminergic neurons to degeneration in Parkinson's disease$354,601

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamAssociate Professor Phillip Dickson, Emeritus Professor Peter Dunkley, Associate Professor Kay Double
SchemeProject Grant
RoleInvestigator
Funding Start2012
Funding Finish2012
GNoG1100113
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

20111 grants / $25,000

Brain Mechanisms Conferring Psychostimulant Addiction$25,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Chris Dayas, Emeritus Professor Peter Dunkley, Doctor Doug Smith
SchemeNear Miss Grant
RoleInvestigator
Funding Start2011
Funding Finish2011
GNoG1001052
Type Of FundingInternal
CategoryINTE
UONY

20101 grants / $24,686

The central neural pathway that controls the release of catecholaines from the adrenal medulla: It is impaired in hypertension?$24,686

Funding body: Hunter Children`s Research Foundation

Funding bodyHunter Children`s Research Foundation
Project TeamDoctor Larisa Bobrovskaya, Associate Professor Ann Goodchild, Emeritus Professor Peter Dunkley
SchemeResearch Grant
RoleInvestigator
Funding Start2010
Funding Finish2010
GNoG0900143
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

20092 grants / $545,000

20083 grants / $559,204

Dopamine mechanisms conferring resilience to depression: A new antidepressant target$538,500

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Trevor Day, Emeritus Professor Peter Dunkley, Professor David Pow, Doctor Doug Smith
SchemeProject Grant
RoleInvestigator
Funding Start2008
Funding Finish2008
GNoG0187604
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Neurobiology of sustained phosphorylation$18,800

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding bodyUniversity of Newcastle - Faculty of Health and Medicine
Project TeamDoctor Larisa Bobrovskaya, Emeritus Professor Peter Dunkley
SchemePilot Grant
RoleInvestigator
Funding Start2008
Funding Finish2008
GNoG0189081
Type Of FundingInternal
CategoryINTE
UONY

Asian Pacific Society for Neurochemistry Biennial Meeting, Hope Island, Shanghai, China, 23/6/2008 - 26/6/2008$1,904

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamEmeritus Professor Peter Dunkley
SchemeTravel Grant
RoleLead
Funding Start2008
Funding Finish2008
GNoG0188912
Type Of FundingInternal
CategoryINTE
UONY

20074 grants / $771,575

Heat Shock Proteins in Myometrium$437,750

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Roger Smith, Emeritus Professor Peter Dunkley, Professor Alistair Sim, Conjoint Associate Professor Andrew Bisits
SchemeProject Grant
RoleInvestigator
Funding Start2007
Funding Finish2007
GNoG0186406
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Differential regulation of human tyrosine hydroxylase isoforms and the development of Parkinson's disease$312,750

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamAssociate Professor Phillip Dickson, Emeritus Professor Peter Dunkley, Associate Professor Kay Double
SchemeProject Grant
RoleInvestigator
Funding Start2007
Funding Finish2007
GNoG0186394
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Vulnerability to depression: the role of dopamine pathways$20,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Trevor Day, Emeritus Professor Peter Dunkley, Doctor Doug Smith, Professor David Pow
SchemeNear Miss Grant
RoleInvestigator
Funding Start2007
Funding Finish2007
GNoG0187196
Type Of FundingInternal
CategoryINTE
UONY

7th International Brain Research Organisation World Congress of Neuroscience, Melbourne, 12/7/2007 - 17/7/2007$1,075

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamEmeritus Professor Peter Dunkley
SchemeTravel Grant
RoleLead
Funding Start2007
Funding Finish2007
GNoG0187748
Type Of FundingInternal
CategoryINTE
UONY

20066 grants / $2,007,868

Advanced technology for transcriptomics, genomics and gene mapping$850,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamProfessor Rodney Scott, Professor Ian Dawes, Professor Ronald Trent, Professor Nicholas Hunt, Emeritus Professor Peter Bergquist, Professor Mark Baker, Emeritus Professor Peter Dunkley, Dr Ruby Lin, Conjoint Professor Peter Gibson, Professor Alistair Sim
SchemeLinkage Infrastructure Equipment & Facilities (LIEF)
RoleInvestigator
Funding Start2006
Funding Finish2006
GNoG0185547
Type Of FundingScheme excluded from IGS
CategoryEXCL
UONY

PRC - Priority Research Centre for Brain & Mental Health Research (CBMHR)$524,282

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamConjoint Professor Chris Levi, Professor Amanda Baker, Professor Mike Calford, Professor Trevor Day, Emeritus Professor Peter Dunkley, Professor Michael Hazelton, Professor Andrew Heathcote, Professor Brian Kelly, Conjoint Professor Vaughan Carr, Emeritus Professor Patricia Michie, Professor David Pow, Emeritus Professor John Rostas, Professor Ulli Schall, Professor Alistair Sim, Professor Mike Startup
SchemePriority Research Centre
RoleInvestigator
Funding Start2006
Funding Finish2006
GNoG0186947
Type Of FundingInternal
CategoryINTE
UONY

Differential regulation of human tyrosine hydroxyase isoforms and susceptibility of dopaminergic neurons to degeneration$10,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamAssociate Professor Phillip Dickson, Emeritus Professor Peter Dunkley, Associate Professor Kay Double
SchemeNear Miss Grant
RoleInvestigator
Funding Start2006
Funding Finish2006
GNoG0186079
Type Of FundingInternal
CategoryINTE
UONY

Asian Pacific Society for Neurochemistry (APSN), 2-5 July 2006$1,448

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamEmeritus Professor Peter Dunkley
SchemeTravel Grant
RoleLead
Funding Start2006
Funding Finish2006
GNoG0186518
Type Of FundingInternal
CategoryINTE
UONY

BioRad Mini-PROTEAN3 Electrophoresis system$995

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamEmeritus Professor Leonie Ashman, Associate Professor Phillip Dickson, Emeritus Professor Peter Dunkley, Emeritus Professor John Rostas, Professor Judith Scott, Professor Alistair Sim, Doctor Nikki Verrills
SchemeEquipment Grant
RoleInvestigator
Funding Start2006
Funding Finish2006
GNoG0187280
Type Of FundingNot Known
CategoryUNKN
UONY

20054 grants / $576,189

A novel mechanism for the maintenance of catecholamine synthesis$351,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamEmeritus Professor Peter Dunkley, Associate Professor Phillip Dickson
SchemeProject Grant
RoleLead
Funding Start2005
Funding Finish2005
GNoG0184211
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Control of Dopamine synthesis and Parkinsons' disease$10,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamAssociate Professor Phillip Dickson, Emeritus Professor Peter Dunkley
SchemeProject Grant
RoleInvestigator
Funding Start2005
Funding Finish2005
GNoG0185977
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Regulation of Human Tyrosine Hydroxylase Isoforms by Hierarchical Phosphorylation$8,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamAssociate Professor Phillip Dickson, Emeritus Professor Peter Dunkley
SchemeProject Grant
RoleInvestigator
Funding Start2005
Funding Finish2005
GNoG0184779
Type Of FundingInternal
CategoryINTE
UONY

20041 grants / $187,341

Biacore3000-Expansion of Proteomics Facility$187,341

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamProfessor Alistair Sim, Laureate Professor John Aitken, Emeritus Professor Peter Dunkley, Emeritus Professor John Rostas, Associate Professor Phillip Dickson, Emeritus Professor Leonie Ashman, Professor Roger Smith, Professor Gordon Burns, Professor Adam McCluskey, Associate Professor Paul Tooney, Dr Fraser Ross, Conjoint Professor Ray Rose
SchemeLinkage Infrastructure Equipment & Facilities (LIEF)
RoleInvestigator
Funding Start2004
Funding Finish2004
GNoG0183030
Type Of FundingScheme excluded from IGS
CategoryEXCL
UONY

20034 grants / $170,000

Hierarchical Phosphorylation of Tyrosine Hydroxylase is Dependent on the Activation Sequence of Signaling Pathways.$135,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamAssociate Professor Phillip Dickson, Emeritus Professor Peter Dunkley
SchemeDiscovery Projects
RoleInvestigator
Funding Start2003
Funding Finish2003
GNoG0182096
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Molecular Mechanisms of Lead-Induced Neurotoxicity$15,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamEmeritus Professor Peter Dunkley, Dr Perry Hartfield
SchemeProject Grant
RoleLead
Funding Start2003
Funding Finish2003
GNoG0182478
Type Of FundingInternal
CategoryINTE
UONY

Signal transduction in clutured astrocytes in relation to morphology and intracellular hydrogen ion concentration (pHi)$10,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamConjoint Professor Richard Rodnight, Emeritus Professor Peter Dunkley
SchemeProject Grant
RoleInvestigator
Funding Start2003
Funding Finish2003
GNoG0182429
Type Of FundingInternal
CategoryINTE
UONY

Sparke Helmore Prime Television Corporate Triathlon Award for Research Excellence$10,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamEmeritus Professor Peter Dunkley
SchemeResearch Grant
RoleLead
Funding Start2003
Funding Finish2003
GNoG0182732
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

20024 grants / $777,647

Proteomic and Genomic Analysis Facility.$473,332

Funding body: Wellcome Trust

Funding bodyWellcome Trust
Project TeamProfessor Alistair Sim, Emeritus Professor Peter Dunkley, Emeritus Professor John Rostas, Professor Rodney Scott, Emeritus Professor Leonie Ashman
SchemeMajor Equipment Award
RoleInvestigator
Funding Start2002
Funding Finish2002
GNoG0181527
Type Of FundingScheme excluded from IGS
CategoryEXCL
UONY

Control of catecholamine synthesis and secretion by angiotensin II$270,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamEmeritus Professor Peter Dunkley, Associate Professor Phillip Dickson
SchemeProject Grant
RoleLead
Funding Start2002
Funding Finish2002
GNoG0180883
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Peltier Thermal Cycler and associated equipment essential for establishing cDNA Retroviral Libraries$21,315

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamEmeritus Professor Leonie Ashman, Dr Petranel Ferrao, Professor Gordon Burns, Professor Alistair Sim, Emeritus Professor Peter Dunkley, Emeritus Professor John Rostas, Associate Professor Phillip Dickson, Professor Dirk Van Helden, Dr Perry Hartfield
SchemeEquipment Grant
RoleInvestigator
Funding Start2002
Funding Finish2002
GNoG0181919
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Heat Shock Protein Function in Nerve Cell Death$13,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDr Perry Hartfield, Emeritus Professor Peter Dunkley
SchemeProject Grant
RoleInvestigator
Funding Start2002
Funding Finish2002
GNoG0181348
Type Of FundingInternal
CategoryINTE
UONY

20014 grants / $62,540

The Effect of Lead on Cells$26,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamEmeritus Professor Peter Dunkley, Dr Perry Hartfield
SchemeNIB Hunter Golf Professionals Charity Golf Day
RoleLead
Funding Start2001
Funding Finish2001
GNoG0180752
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Control of Catecholamine Synthesis by Tyrosine Hydroxylase.$13,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamEmeritus Professor Peter Dunkley, Associate Professor Phillip Dickson, Emeritus Professor Ellak Von Nagy-Felsobuki, Professor Alistair Sim
SchemeProject Grant
RoleLead
Funding Start2001
Funding Finish2001
GNoG0180125
Type Of FundingInternal
CategoryINTE
UONY

Thermocycler with 96 well sample block for PCR reactions. Class II Biological Safety Cabinet. Liquid Nitrogen storage Dewar & Transport Dewar$11,770

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamEmeritus Professor Peter Dunkley, Professor Alistair Sim, Professor Dirk Van Helden, Professor Robert Callister
SchemeEquipment Grant
RoleLead
Funding Start2001
Funding Finish2001
GNoG0181178
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Thermocycler with 96 well sample block for PCR reactions. Class II Biological Safety Cabinet. Liquid Nitrogen storage Dewar & Transport Dewar$11,770

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamEmeritus Professor Peter Dunkley, Professor Alistair Sim, Professor Dirk Van Helden, Professor Robert Callister
SchemeUniversity/NHMRC Equipment Grant Funds
RoleLead
Funding Start2001
Funding Finish2001
GNoG0181179
Type Of FundingInternal
CategoryINTE
UONY

20004 grants / $64,000

Neurolucida Imaging System.$24,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamConjoint Professor Loris Chahl, Associate Professor Paul Tooney, Emeritus Professor Peter Dunkley, Emeritus Professor John Rostas
SchemeEquipment Grant
RoleInvestigator
Funding Start2000
Funding Finish2000
GNoG0179167
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Control of Catecholamine Synthesis by Tyrosine Hydroxylase.$14,500

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamEmeritus Professor Peter Dunkley, Associate Professor Phillip Dickson, Emeritus Professor Ellak Von Nagy-Felsobuki
SchemeSmall Grant
RoleLead
Funding Start2000
Funding Finish2000
GNoG0178980
Type Of FundingScheme excluded from IGS
CategoryEXCL
UONY

Regulating the Regulator: Using Immunochemical Tools to Reveal How CaMPK-II is Controlled by Phosporylation In Vivo.$13,500

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamEmeritus Professor John Rostas, Emeritus Professor Peter Dunkley, Dr Martin Cammarota, Dr Sabine Fieuw-Makaroff
SchemeProject Grant
RoleInvestigator
Funding Start2000
Funding Finish2000
GNoG0178869
Type Of FundingInternal
CategoryINTE
UONY

Mechanisms of ATP-stimulated phosphorylation and activation of tyrosine hydroxylase.$12,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDr Tat Cheah, Emeritus Professor Peter Dunkley, Conjoint Professor David Powis
SchemeProject Grant
RoleInvestigator
Funding Start2000
Funding Finish2000
GNoG0178904
Type Of FundingInternal
CategoryINTE
UONY

19994 grants / $241,816

Mechanisms of angiotensin-stimulated phosphorylation & activation of tyrosine hydroxylase$203,316

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamEmeritus Professor Peter Dunkley, Conjoint Professor David Powis, Dr Tat Cheah
SchemeProject Grant
RoleLead
Funding Start1999
Funding Finish1999
GNoG0178348
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

FPLC Protein Purification System$16,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Alistair Sim, Emeritus Professor John Rostas, Emeritus Professor Peter Dunkley, Associate Professor Phillip Dickson
SchemeEquipment Grant
RoleInvestigator
Funding Start1999
Funding Finish1999
GNoG0180790
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Determination of the Phosphorylation States of Tyrosine Hyroxylase in Bovine Adrenal Chromaffin Cells by Electrospray Mass Spectrometry.$13,500

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamEmeritus Professor Ellak Von Nagy-Felsobuki, Emeritus Professor Peter Dunkley
SchemeSmall Grant
RoleInvestigator
Funding Start1999
Funding Finish1999
GNoG0178016
Type Of FundingScheme excluded from IGS
CategoryEXCL
UONY

Development of a cellular model to study regulation of neurotransmitter synthesis$9,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamAssociate Professor Phillip Dickson, Emeritus Professor Peter Dunkley
SchemeProject Grant
RoleInvestigator
Funding Start1999
Funding Finish1999
GNoG0178050
Type Of FundingInternal
CategoryINTE
UONY

19983 grants / $66,000

Molecular Dynamics Storm 860 Tri-mode Analysis System$35,000

Funding body: Ramaciotti Foundations

Funding bodyRamaciotti Foundations
Project TeamProfessor Alistair Sim, Emeritus Professor John Rostas, Emeritus Professor Peter Dunkley, Dr Stephen Bunn, Dr Tat Cheah, Conjoint Professor Kenneth Beagley, Conjoint Professor Ray Rose, Professor Judith Scott, Doctor Cheng Chan, Professor Roger Smith
SchemeResearch Grant
RoleInvestigator
Funding Start1998
Funding Finish1998
GNoG0177453
Type Of FundingAust Competitive - Non Commonwealth
Category1NS
UONY

Identification of protein phosphatases acting on Tyrosine Hydroxylase in bovine adrenal chromaffin cells.$19,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamEmeritus Professor Peter Dunkley, Professor Alistair Sim, Dr Tat Cheah
SchemeProject Grant
RoleLead
Funding Start1998
Funding Finish1998
GNoG0177219
Type Of FundingInternal
CategoryINTE
UONY

Determination of the Phoshorylation States of Tyrosine Hydroxylase in Bovine Adrenal Chromaffin Cells by Electrospray Mass Spectrometry$12,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamEmeritus Professor Ellak Von Nagy-Felsobuki, Emeritus Professor Peter Dunkley
SchemeSmall Grant
RoleInvestigator
Funding Start1998
Funding Finish1998
GNoG0177304
Type Of FundingScheme excluded from IGS
CategoryEXCL
UONY

19976 grants / $557,193

Newcastle Protein - A Protein Sequencing and Analysis Unit of the Newcastle Biomolecular Research Facility.$200,000

Funding body: Department of Education, Training & Youth Affairs

Funding bodyDepartment of Education, Training & Youth Affairs
Project TeamEmeritus Professor Peter Dunkley
SchemeResearch Infrastructure Equipment & Facilities (RIEF)
RoleLead
Funding Start1997
Funding Finish1997
GNoG0176524
Type Of FundingScheme excluded from IGS
CategoryEXCL
UONY

Role of Protein Phosphorylation in the Control of Glutamate Release from Nerve Terminals.$178,409

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamEmeritus Professor Peter Dunkley, Dr B Walmsley, Professor Alistair Sim, Dr Stephen Bunn
SchemeProject Grant
RoleLead
Funding Start1997
Funding Finish1997
GNoG0176252
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Exocytosis and the Calcium Regulation of Phospholipase C Isozymes$143,284

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamEmeritus Professor Peter Dunkley, Dr Stephen Bunn
SchemeProject Grant
RoleLead
Funding Start1997
Funding Finish1997
GNoG0176253
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Modulation of Neurotransmitted Release by Carboxyl-methylation and tyrosine Phosphorylation of Protein Phosphatase type 2A.$18,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamProfessor Alistair Sim, Doctor Paul Brent, Emeritus Professor Peter Dunkley
SchemeSmall Grant
RoleInvestigator
Funding Start1997
Funding Finish1997
GNoG0176731
Type Of FundingScheme excluded from IGS
CategoryEXCL
UONY

Biomedical applications using an electrospray mass spectrometer$15,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamEmeritus Professor Ellak Von Nagy-Felsobuki, Emeritus Professor Peter Dunkley
SchemeSmall Grant
RoleInvestigator
Funding Start1997
Funding Finish1997
GNoG0176739
Type Of FundingScheme excluded from IGS
CategoryEXCL
UONY

International society for Neurochemistry, Boston, USA, 20-25 July 1997$2,500

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamEmeritus Professor Peter Dunkley
SchemeTravel Grant
RoleLead
Funding Start1997
Funding Finish1997
GNoG0179452
Type Of FundingInternal
CategoryINTE
UONY

19963 grants / $66,000

Microscope and infra-red camera$42,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamDr Pankaj Sah, Dr B Walmsley, Emeritus Professor Peter Dunkley, Professor Dirk Van Helden
SchemeEquipment Grant
RoleInvestigator
Funding Start1996
Funding Finish1996
GNoG0175473
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Establishment of techniques for preparing genetically engineered molecules to study the regulation of neuronal and cellular function$12,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamEmeritus Professor John Rostas, Emeritus Professor Peter Dunkley, Professor Robert Callister
SchemeProject Grant
RoleInvestigator
Funding Start1996
Funding Finish1996
GNoG0175744
Type Of FundingInternal
CategoryINTE
UONY

Effects of angiotensin II on tyrosine hydroxylase activity and phosphorylation in bovine adrenal chromaffin cells.$12,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamEmeritus Professor Peter Dunkley, Dr Tat Cheah, Dr Stephen Bunn
SchemeProject Grant
RoleLead
Funding Start1996
Funding Finish1996
GNoG0175838
Type Of FundingInternal
CategoryINTE
UONY

19956 grants / $401,743

The mechanism and significance of tyrosine hydroxylase phosphorylation.$166,805

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamEmeritus Professor Peter Dunkley, Dr Stephen Bunn, Dr Tat Cheah
SchemeProject Grant
RoleLead
Funding Start1995
Funding Finish1995
GNoG0174549
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Regulation of signal transduction pathways by sigma ligands: mechanisms and significance.$144,626

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamDoctor Paul Brent, Emeritus Professor Peter Dunkley
SchemeProject Grant
RoleInvestigator
Funding Start1995
Funding Finish1995
GNoG0174539
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Neuroscience Group$59,000

Funding body: Department of Education, Training & Youth Affairs

Funding bodyDepartment of Education, Training & Youth Affairs
Project TeamEmeritus Professor Peter Dunkley
SchemeResearch Infrastructure Block Grant (RIBG)
RoleLead
Funding Start1995
Funding Finish1995
GNoG0175584
Type Of FundingScheme excluded from IGS
CategoryEXCL
UONY

95APP. High resolution purification of intra-cellular signalling proteins from brain by FPLC.$20,000

Funding body: Ramaciotti Foundations

Funding bodyRamaciotti Foundations
Project TeamProfessor Alistair Sim, Emeritus Professor Peter Dunkley, Emeritus Professor John Rostas
SchemeResearch Grant
RoleInvestigator
Funding Start1995
Funding Finish1995
GNoG0174696
Type Of FundingAust Competitive - Non Commonwealth
Category1NS
UONY

Establishment of new model systems and techniques for studying neurotransmision$9,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamEmeritus Professor Peter Dunkley, Emeritus Professor John Rostas, Dr B Walmsley
SchemeProject Grant
RoleLead
Funding Start1995
Funding Finish1995
GNoG0174902
Type Of FundingInternal
CategoryINTE
UONY

15th Biennial Mtg of Intern. Society for Neurochemistry, Japan, 2-7 July$2,312

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamEmeritus Professor Peter Dunkley
SchemeTravel Grant
RoleLead
Funding Start1995
Funding Finish1995
GNoG0176857
Type Of FundingInternal
CategoryINTE
UONY

19945 grants / $58,000

Mechanism of Nitric Oxide Modulation of Secretion in Autonomic Ganglia$22,500

Funding body: National Heart Foundation of Australia

Funding bodyNational Heart Foundation of Australia
Project TeamEmeritus Professor Peter Dunkley, Emeritus Professor John Rostas
SchemeGrant-In-Aid
RoleLead
Funding Start1994
Funding Finish1994
GNoG0175235
Type Of FundingAust Competitive - Non Commonwealth
Category1NS
UONY

Establishment of new model systems and techniques for studying neurotransmission$13,500

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamEmeritus Professor John Rostas, Emeritus Professor Peter Dunkley, Dr B Walmsley
SchemeSmall Grant
RoleInvestigator
Funding Start1994
Funding Finish1994
GNoG0174822
Type Of FundingScheme excluded from IGS
CategoryEXCL
UONY

94 APP The effect of Vitamin A deficiency on intestinal structure, function and mucosal repair$11,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamMs Rosemary Warden, Ted O'Loughlin, Emeritus Professor Peter Dunkley
SchemeProject Grant
RoleInvestigator
Funding Start1994
Funding Finish1994
GNoG0174784
Type Of FundingInternal
CategoryINTE
UONY

The control of tyrosine hydroxylase activity by protein phosphorylation.$6,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamEmeritus Professor Peter Dunkley, Dr Stephen Bunn, Professor Alistair Sim
SchemeProject Grant
RoleLead
Funding Start1994
Funding Finish1994
GNoG0174737
Type Of FundingInternal
CategoryINTE
UONY

Do sigma binding site ligands modulate neurotransmission by molecular mechanisms involving protein phosphorylation in neuronal tissue$5,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Paul Brent, Emeritus Professor Peter Dunkley, Professor Alistair Sim
SchemeProject Grant
RoleInvestigator
Funding Start1994
Funding Finish1994
GNoG0174732
Type Of FundingInternal
CategoryINTE
UONY

19932 grants / $245,861

Autophosphorylation of Calcium/Calmodulin-stimulated Protein Kinase II.$243,361

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamEmeritus Professor Peter Dunkley
SchemeProject Grant
RoleLead
Funding Start1993
Funding Finish1993
GNoG0173162
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

'Intern. Society for Neurochemistry', Montpellier, France, 22 - 27 August 1993$2,500

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamEmeritus Professor Peter Dunkley
SchemeTravel Grant
RoleLead
Funding Start1993
Funding Finish1993
GNoG0174385
Type Of FundingInternal
CategoryINTE
UONY

19922 grants / $317,024

92,93,94GRANT. The Regulation Of Protein Phosphatases In The Brain$183,006

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Alistair Sim, Emeritus Professor Peter Dunkley, Emeritus Professor John Rostas
SchemeProject Grant
RoleInvestigator
Funding Start1992
Funding Finish1992
GNoG0174274
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

The Role Of Inositol (1,4,5) Trisphosphate In The Adrenal Chromaffin Cell$134,018

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamDr Stephen Bunn, Emeritus Professor Peter Dunkley
SchemeProject Grant
RoleInvestigator
Funding Start1992
Funding Finish1992
GNoG0174260
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

19912 grants / $83,378

Calmodulin Kinases: Roles in Hormone and Neurotransmitter Release.$45,826

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamEmeritus Professor Peter Dunkley
SchemeProject Grant
RoleLead
Funding Start1991
Funding Finish1991
GNoG0173950
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Beta Scintillation Spectrometer$37,552

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamConjoint Professor David Powis, Emeritus Professor Peter Dunkley, Emeritus Professor John Rostas, Emeritus Professor Anthony Smith
SchemeEquipment Grant
RoleInvestigator
Funding Start1991
Funding Finish1991
GNoG0173965
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY
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Research Supervision

Current Supervision

CommencedResearch Title / Program / Supervisor Type
2015Role of Inflammation in Parkinson's Disease
Medical Science, Faculty of Health and Medicine
Co-Supervisor
2007Catecholamine binding sites on tyrosine hydroxylase
Biochemistry & Cell Biology, University of Newcastle
Co-Supervisor

Past Supervision

YearResearch Title / Program / Supervisor Type
2015Regulation of Tyrosine Hydroxylase in Stress and Parkinson's Disease
Medical Science, Faculty of Health and Medicine
Co-Supervisor
2013Investigation of Catecholamine Inhibition in Tyrosine Hydroxylase
Medical Science, Faculty of Health and Medicine
Co-Supervisor
2012Neurobiological Consequences of Stress: Tyrosine Hydroxylase Phosphorylation in Response to Stress
Medical Science, Faculty of Health and Medicine
Principal Supervisor
2012Dopaminergic Pathway Imbalance in the Neurobiology of Depression
Human Biology, Faculty of Health and Medicine
Co-Supervisor
2010Differential Distribution of Tyrosine Hydroxylase Isoforms and Phosphorylation in Parkinson Disease
Medical Science, Faculty of Health and Medicine
Co-Supervisor
2009Acute Regulation of Tyrosine Hydroxylase
Medical Science, Faculty of Health and Medicine
Co-Supervisor
2005The effects of antidepressant drugs on catecholamine synthesis
Biochemistry & Cell Biology, University of Newcastle
Co-Supervisor
2004A model for the sustained activation of tyrosine hydroxylase
Biochemistry & Cell Biology, University of Newcastle
Co-Supervisor
2004Catecholamine binding sites in tyrosine hydroxylase
Biochemistry & Cell Biology, University of Newcastle
Co-Supervisor
2003Regulation of tyrosine hydroxylase phosphorylation by Angiotensin II
Biochemistry & Cell Biology, University of Newcastle
Co-Supervisor
2002The regulation of tyrosine hydroxylase
Biochemistry & Cell Biology, University of Newcastle
Co-Supervisor
2001Characterisation of tyrosine hydroxylase phosphorylation by mass spectrosopy
Biochemistry & Cell Biology, University of Newcastle
Co-Supervisor
2000The control of tyrosine hydroxylase phosphorylation in bovine adrenal chromaffin cells
Biochemistry & Cell Biology, University of Newcastle
Sole Supervisor
1999The regulation of phospholipase c1 in bovine adrenal chromaffin cells
Biochemistry & Cell Biology, University of Newcastle
Co-Supervisor
1999Angiotensin II-stimulated tyrosine hydroxylase activity and phosphorylation in bovine adrenal chromaffin cells
Biochemistry & Cell Biology, University of Newcastle
Sole Supervisor
1997Vitamin A deficiency and intestinal structure and function in the rat
Biochemistry & Cell Biology, University of Newcastle
Co-Supervisor
1996Embryo-fetotoxicity of prenatal alcohol exposure and its relationship to oxidative stress
Biochemistry & Cell Biology, University of Newcastle
Co-Supervisor
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Emeritus Professor Peter Dunkley

Positions

Emeritus Professor
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

One Off - Casual Lecturer
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

Focus area

Medical Biochemistry

Contact Details

Emailpeter.dunkley@newcastle.edu.au
Phone(02) 4921 5600
Fax(02) 4921 6903

Office

RoomMSB506
BuildingMedical Sciences Building
LocationCallaghan
University Drive
Callaghan, NSW 2308
Australia
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