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Laureate Professor Paul Foster

Laureate Professor

School of Biomedical Sciences and Pharmacy (Immunology and Microbiology)

Joining forces to ease the wheeze

Australia's two million sufferers of airway disease can breathe easier thanks to the work of the University's groundbreaking respiratory researchers.

Laureate Professor Paul FosterFrom the bench to the bedside, the University of Newcastle's Priority Research Centre for Asthma and Respiratory Diseases is leading the way in the understanding, management and treatment of chronic airway conditions.

Centre co-directors Laureate Professor Paul Foster and Professor Peter Gibson lead highly talented teams of scientists and doctors who integrate the latest advances in laboratory technology and methodology with innovative, patient-focused research.

The work of the Centre is internationally recognised, having contributed significantly to advancing both medical practice and policy through its discoveries.

Its studies are regularly published in the most prestigious journals and it is a major training hub for respiratory medicine and immunology, attracting gifted PhD students and postdoctoral researchers from around the world to work and study in Newcastle.

Foster and Gibson's teams work under the umbrella of the Hunter Medical Research Institute (HMRI), a partnership between the University of Newcastle and Hunter New England Health. They also collaborate with research groups in Sydney, Newcastle, Melbourne and Perth as part of the Cooperative Research Centre for Asthma and Airways, a $55 million government-backed program.

Gibson is working at the clinical interface, using his role as a respiratory physician at the John Hunter Hospital in Newcastle to inform his research into treatments and management strategies for asthma and airway disease.

Foster, the University's Chair in Immunology, investigates the molecular and cellular mechanisms of disease in the laboratory. Both have a keen interest in unravelling the critical role of inflammation in asthma and other respiratory conditions.

"We are constantly on the lookout for better treatments but with a disease like asthma, management is also important," Gibson says.

"For some people, just understanding what is happening to them is enough to make a big difference to their condition and quality of life."

Gibson's clinically based team is involved in research projects with significant implications for future treatment and management of airway disease (see below).

Novel discoveries have also been made by the centre's laboratory-based researchers.  These discoveries have enhanced the understanding of processes associated with the development and progression of respiratory diseases.

Centre scientists study the cellular and molecular functions of the diseases on animal models then collaborate with the clinical researchers to validate their findings using human tissue.

Foster says the centre is at the forefront of interpreting how inflammation, which underpins airway disease, occurs and of developing new anti-inflammatory treatments.

A major breakthrough was their research into how microRNA molecules, which regulate protein production in human cells, can cause inflammation in the body that can manifest as asthma. Working out how to control that inflammatory response has provided scientists with a therapeutic target, which could lead to new treatments.

"Steroids are the conventional treatment, but they can have side effects and while they dampen response, they do not cure the disease," Foster explains.

"Also, not everyone is responsive to steroids and within that non-responsive group there is a lot of morbidity."

Foster says his team has made a significant contribution to the understanding of the mechanisms of steroid-resistant inflammatory pathways that may be relevant to asthma, bringing them closer to the goal of developing alternative treatments. Other critical areas of laboratory research focus on allergies, viruses and infection as triggers for asthma.

While the two arms of research within the centre are undertaken by different teams, Foster says it is the critical mass that contributes to its overall success.

"What we have is diversity and common interest," he says. "There are similar centres of excellence around the world but they primarily do either clinical-based research or basic immunology. The way the two are integrated here is what makes us unique and underpins our success."

"People are willing to collaborate," Gibson agrees, "and it is only by linking patient-focused research with laboratory discoveries and evidence-based medicine that we are able to get these broad insights into disease."

Leading the wayProfessor Paul Foster and Professor Peter Gibson talking

Professor Peter Gibson's clinical research team is leading three groundbreaking projects that could revolutionise the treatment of asthma.

These specific projects involve better management of asthma in pregnancy, the development of a blood test to diagnose the disease and the treatment of non-eosinophilic asthma with macrolide antibiotics.

The team's study into asthma in pregnancy was prompted by the reluctance of women to use treatments during gestation, even though severe asthmatic episodes can be harmful to both mother and child.

As part of this project, researchers measured nitric oxide, which is produced by inflamed airways, in the pregnant patient's exhaled breath. They were then able to adjust the amount of medication according to the severity of the inflammation.

In many cases this reduced the amount of steroid that needed to be administered, which made women more likely to take their medication as they were less apprehensive about the treatment and its effects on their unborn child.

Another benefit was that the frequency of asthma exacerbations, or episodes, decreased because the condition was being better managed.

In another study, published this year in the American Journal of Respiratory and Critical Care Medicine, the team used the emerging scientific field of proteomics (the study of proteins) to identify four blood-based biomarkers that when analysed together can distinguish between asthma and chronic obstructive pulmonary disease.

The two diseases share common symptoms, so are difficult to distinguish, but require different therapeutic approaches.

This finding could lead to the development of the first blood test for asthma, which would be a major diagnostic breakthrough.

The third project is the AMAZES study (Asthma and Macrolides: Azithromycin Efficacy and Safety). It will trial an alternative treatment, known as a macrolide antibiotic, for asthma that is not responsive to conventional steroid medication.

Steroids treat a particular cell, called an eosinophil, which is thought to provoke inflammation when present in increased levels. But research has established that up to half of adults with asthma symptoms have normal levels of eosinophils and respond poorly to conventional treatment.

The five-year, $2.9 million study is trialling the antibiotic on approximately 400 asthmatics in four cities and is the biggest study into non-eosinophilic asthma in the world.  It is funded by the National Health and Medical Research Council.

Visit the Priority Research Centre for Asthma and Respiratory Diseases website

Visit the Hunter Medical Research Institute (HMRI) website

Joining forces to ease the wheeze

Joining forces to ease the wheeze

Australia's two million sufferers of airway disease can breathe easier thanks to the work of the University's groundbreaking respiratory researchers Professors Paul Foster and Peter Gibson.

Read more

Career Summary

Biography

Professor Paul Foster is the Director of the Priority Research Centre for Asthma and Respiratory Disease; the Virus, Infection/Immunity, Vaccines and Asthma Program, Hunter Medical Research Institute and the Cooperative Research Centre (CRC) for Asthma and Airways (Newcastle node). He also currently holds the Chair of Immunology, School of Biomedical Sciences and Pharmacy, Faculty of Health, University of Newcastle. He is also a visiting Professor at Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

He serves as an Associate Editor of the American Journal of Respiratory Cell and Molecular Biology and the Journal of Pharmacology and Therapeutics, and is on the Editorial Boards of a number of leading international immunology/allergy journals. Professor Foster's research focuses on understanding the molecular and cellular basis of asthma, allergy, respiratory disorders, and chronic inflammation.

His research program focuses on translational approaches directed towards the development of novel anti-inflammatory therapies. Professor Foster's research findings are published in the most highly ranked medical and biomedical science journals (e.g. Nature Immunology and Journal of Experimental Medicine). Essential Science Indicators metrics places his team on the forefront of his field internationally. Professor Foster receives numerous and ongoing invitations to speak and chair sessions and leading international conferences in immunology and respiratory medicine (e.g. American Academy of Asthma, Allergy and Immunology, Keystone, Cold Spring Harbor, International Congress on Immunology and International Eosinophil meeting).

The importance of his team's work has been recognised through award of over $10.5 million in direct funding (since 2003) through Australian national competitive grants. Since 1995 Professor Foster's laboratory has focused on the biology of T cells and granulocytes, and on signaling by cytokines and chemokines pertinent to regulating allergic inflammatory responses, in particular asthma.

In the last 5 years we have extended our focus to understanding the relationship between inflammation induced by infection (viruses, bacteria and microbial products), at various times through life, on the subsequent development of the T cell repertoire and on chronic inflammation in the lung. A focus on the role of microRNAs in the regulation of inflammation is also a main focus. Professor Foster's activities have been supported through grants from the NHMRC (program and project grants), Australian Research Council (Discovery and LIEF grants), Human Frontiers Science Foundation, and through the CRC for Asthma and Airways. Professor Foster actively contributes to peer review at a national and international level (e.g. NHMRC; fellowship, program and project reviews/grant panel; Wellcome Trust; and leading international journals (e.g. J. of Clin. Invest., J. of Exp. Med., and Nature).

Professor Foster is also on the Editorial Board of:
• American Journal of Respiratory Cell & Molecular Biology • Pharmacology & Therapeutics (Associate Editor)
• Current Molecular Medicine
• Journal Inflammation and Allergy
• Clinical and Experimental Allergy

Research Expertise

Current research in my laboratory primarily aims at defining the key cellular and molecular processes that underlie the development of allergic disease (lung, skin and gastrointestinal tract) and of viral (RSV and influenza) induced pulmonary inflammation. We are particularly interested in the molecular events that predispose to remodeling of the airways in chronic disease and the subsequent impact on lung function. In particular, projects are focusing on the biology of CD4+ Th2 cells, CD8+ T cells and eosinophils, and in signaling arrangements between cytokine and chemokine systems that pertain to allergic disease, viral induced pathogenesis and viral induced exacerbation of asthma.

Our aim is to develop integrative concepts on molecular mechanisms of pathogenesis by employing an approach that is multifactorial ranging from transgenic systems to the identification of novel gene products. The laboratory has established in vivo models of asthma (acute and chronic), allergic cutaneous disease and of eosinophil and lymphocyte homing to sites of allergen or viral provocation.

Models of RSV infection in the presence and absence of allergic inflammation are also established. These models, in conjunction with mice that are factor deficient or transgenic (constitutive and inducible systems that are airway specific, and T cell transgenic systems), are currently being employed to define the individual role of inflammatory cells and cytokines/chemokines in the pathophysiology of allergic and viral disorders and viral induced exacerbation of allergic inflammation. Collectively, this approach is providing a fundamental platform for the identification of key targets for potential therapeutic intervention in these diseased states and models for the development of novel anti-inflammatory approaches. Models of leukocyte trafficking and pathogenesis are combined with experimental programs at a cellular level to enhance the understanding of the molecular basis of disease. Novel mechanisms to attenuate allergic and viral induced disease are also being explored. We have also established models of chronic obstructive pulmonary disease (COPD).

Current PhD and Honours projects within my team aim to gather an understanding in:
• the role of miRNA in asthma and infection
• the role of viruses in inducing asthma and COPD
• miRNA regulation of leukocyte differentiation
• the innate immune system in severe asthma

Teaching Expertise
• Immunology
• Research Commercialisation

Administrative Expertise
• Hunter Medical Research Institute Building Committee
• Research Committee - Member
• Academic Senate - Member
• Animal Services Research Facility, Advisory Committee, Sub-committee - Member
• Analytical and Biomolecular Research Facility Advisory
• Strategic Research Advisory Panel HMRI - Member
• Research Committee, School of Biomedical Sciences and Pharmacy, University of Newcastle - Member
• Steering Committee, Vaccines, Infection, Virus and Asthma Group, HMRI - Member

Collaborations
I have extensive national and international collaborations and associations with leading investigators and biotechnology and pharmaceutical companies. For example:
• Professor Andrew Mackenzie, Laboratory of Molecular Biology, Cambridge University, UK.
• Professor K Takeda and S Akira, Osaka University, Osaka Japan.
• Professor Marc Rothenberg, Children’s Hospital Medical Centre, Cincinnati, OH.
• Professor Helene Rosenberg, National Institute of Allergy and Infectious Diseases, National Institutes of Health, USA.
• Professor Richard Stevens, Harvard Medical School, Boston MA.
• Professor Sebastian Johnston, Imperial College, London UK.
• Professor Pardric Fallon, Trinity College, Dublin, Ireland.
• GSK.
• MedImmune Inc, Washington DC, USA.
• Commonwealth Serum Laboratories, Parkville, Melbourne, Australia.


Qualifications

  • PhD, Australian National University
  • Bachelor of Science (Honours), University of Western Australia

Keywords

  • Allergy
  • Asthma
  • Biomedical Sciences
  • Chronic Inflammation
  • Immunology
  • Leukocyte Biology
  • Medicine
  • Pharmacy

Fields of Research

CodeDescriptionPercentage
110799Immunology not elsewhere classified75
110299Cardiorespiratory Medicine and Haematology not elsewhere classified25

Professional Experience

UON Appointment

DatesTitleOrganisation / Department
1/09/2014 - ProfessorUniversity of Newcastle
School of Biomedical Sciences and Pharmacy
Australia

Academic appointment

DatesTitleOrganisation / Department
Associate Editor - Pharmacology & TherapeuticsPharmacology & Therapeutics
Australia
1/01/2010 - Visiting ProfessorshipHarvard University
United States
1/01/2008 - Editor - Clinical and Experimental AllergyClinical and Experimental Allergy
Australia
1/01/2008 - Editor - Journal Inflammation and AllergyJournal Inflammation and Allergy
Australia
1/01/2003 - ProfessorUniversity of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
1/01/2003 - ProfessorAustralian National University
Allergy & Inflammation Research Group
Australia
1/01/2002 - Editor - American Journal of Respiratory Cell and Molecular BiologyAmerican Journal of Respiratory Cell and Molecular Biology
United States
1/01/1999 - 1/12/2002Senior FellowAustralian National University
Allergy & Inflammation Research Group
Australia
1/01/1996 - 1/12/1998Fellow Australian National University
Leucocyte Signalling & Regulation Laboratory
Australia

Membership

DatesTitleOrganisation / Department
Member - International Eosinophil SocietyInternational Eosinophil Society
Australia
Member - International Mucosal Immunology SocietyInternational Mucosal Immunology Society
Australia
Member - American Society for ImmunologyAmerican Society for Immunology
United States
Member - The Australian Lung foundationThe Australian Lung foundation
Australia
Member - The Thoracic Society of Australia and New ZealandThe Thoracic Society of Australia and New Zealand
Australia
Member - The Australian Society for ImmunolgyThe Australian Society for Immunolgy
Australia
1/01/2003 - Membership - CRC for Asthma and AirwaysaCRC for Asthma and Airways
Australia
1/01/2003 - 31/12/2003ARC Committee memberARC
Australia

Awards

Recipient

YearAward
2005CRC for Asthma and Airways
University of Newcastle
2003NHMRC Programme Grant 2003-2007
Australian National University

Research Award

YearAward
2010Research Excellence
Hunter Medical Research Institute (HMRI)
1999Australian Academy of Science and The Royal Society Travelling Fellowship
The Australian Academy of Science
1997Human Frontiers Science Programme International Collaborative Grant
Human Frontier Science Program
1996The Asthma Foundation of NSW, The Jean Jeavons grant for Asthma Research
Asthma Foundation of New South Wales
1996The British council Collaborative Research Award
British Council
1996The John curtin School of Medical Research, Howard Florey Young Investigators Award
Australian National University
1994Australian Academy of Science and The Royal Society Travelling Fellowship
The Australian Academy of Science
1983Commonwealth Postgraduate Research Scholarship
Commonwealth

Invitations

Participant

YearTitle / Rationale
2010Congress of the European Academy of Allergy and Clinical Immunology
Organisation: 29th Conference Description:
2010The American Academy of Asthma, Allergy and Immunology (AAAAI)
Organisation: 65th Annual Meeting - Mini-symposium (educational section) Description:
2009Biennial Symposium International Eosinophil Society
Organisation: 6th Conference Description:
2009The American Academy of Asthma, Allergy and Immunology (AAAAI)
Organisation: 64th Annual Meeting - Mini-symposium (educational section) Description:
2008The American Academy of Asthma, Allergy and Immunology (AAAAI)
Organisation: 63nd Annual Meeting - Mini-symposium (educational section). Description:
2007Molecular Therapeutics of Cancer
Organisation: Gordon Conference Description:
2007Biennial Symposium International Eosinophil Society
Organisation: 5th Conference Description:
2007International Congress of Immunology
Organisation: 14th Conference Description:
2006The American Academy of Asthma, Allergy and Immunology (AAAAI)
Organisation: 61st Annual Meeting - Mini-symposium (educational section) Description:
2005The American Academy of Asthma, Allergy and Immunology (AAAAI)
Organisation: 60th Annual Meeting - Symposium Chemokines and Receptors Description:
200412th International Congress on Immunology
Organisation: 4th Annual Conerence of FOCIS Description:
200425th International Symposium
Organisation: Collegium Internationalale Allergologicum Description:
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Chapter (8 outputs)

YearCitationAltmetricsLink
2015Maltby S, Plank M, Ptaschinski C, Mattes J, Foster PS, 'Microrna function in mast cell biology: protocols to characterize and modulate microrna expression', , Humana Press Inc. 287-304 (2015)

MicroRNAs (miRNAs) are small noncoding RNA molecules that can modulate mRNA levels through RNA-induced silencing complex (RISC)-mediated degradation. Recognition of target mRNAs occurs through imperfect base pairing between an miRNA and its target, meaning that each miRNA can target a number of different mRNAs to modulate gene expression. miRNAs have been proposed as novel therapeutic targets and many studies are aimed at characterizing miRNA expression patterns and functions within a range of cell types. To date, limited research has focused on the function of miRNAs specifi cally in mast cells; however, this is an emerging fi eld. In this chapter, we will briefl y overview miRNA synthesis and function and the current understanding of miRNAs in hematopoietic development and immune function, emphasizing studies related to mast cell biology. The chapter will conclude with fundamental techniques used in miRNA studies, including RNA isolation, real-time PCR and microarray approaches for quantifi cation of miRNA expression levels, and antagomir design to interfere with miRNA function.

DOI10.1007/978-1-4939-1568-2_18,
Co-authorsSteven Maltby, Joerg Mattes
2015Maltby S, Plank M, Ptaschinski C, Mattes J, Foster PS, 'Microrna function in mast cell biology: protocols to characterize and modulate microrna expression', , Humana Press Inc. 287-304 (2015)
DOI10.1007/978-1-4939-1568-2_18,
Co-authorsJoerg Mattes, Steven Maltby
2013Lee JJ, Ptaschinski C, Plank M, Mattes J, Foster PS, Balla KM, et al., 'Emerging Concepts', Eosinophils in Health and Disease, Academic Press, London 607-641 (2013) [B1]
DOI10.1016/B978-0-12-394385-9.00016-X
Co-authorsJoerg Mattes
2008Hogan SP, Rosenberg HF, Moqbel R, Phipps S, Foster PS, Lacy P, et al., 'Eosinophils: Biological properties and role in health and allergic diseases', Allergy and Allergic Diseases, Wiley-Blackwell, Hoboken 258-294 (2008) [B1]
CitationsWeb of Science - 284
2004Kumar RL, Foster PS, 'Lessons from a model of chronic asthma', Focus on Asthma, Nova Science Publishers, New York, United States 165-183 (2004) [B1]
2000Simson L, Foster PS, 'Chemokine and Cytokine Cooperativity', Chemokines in Allergic Disease, Marcel Dekker, New York, USA 289-309 (2000) [B1]
1999Ramsay A, Hogan S, Foster PS, Xiong Y, 'Gene therapy of allergic airways inflammation', Progress in Inflammation Research: Gene Therapy of Inflammatory Diseases, Birkhauser Publishing, Basel, Switzerland 65-72 (1999) [B1]
1999Foster PS, Hogan S, Matthaei K, Young I, 'The role of interleukin-5 in allergic airways disease.', Interleukin-5, Marcel Dekker, New York, USA 127-135 (1999) [B1]
Show 5 more chapters

Journal article (214 outputs)

YearCitationAltmetricsLink
2015Su Y-C, Townsend D, Herrero LJ, Zaid A, Rolph MS, Gahan ME, et al., 'Dual proinflammatory and antiviral properties of pulmonary eosinophils in respiratory syncytial virus vaccine-enhanced disease', Journal of Virology, 89 1564-1578 (2015)

Human respiratory syncytial virus (RSV) is a major cause of morbidity and severe lower respiratory tract disease in the elderly and very young, with some infants developing bronchiolitis, recurrent wheezing, and asthma following infection. Previous studies in humans and animal models have shown that vaccination with formalin-inactivated RSV (FI-RSV) leads to prominent airway eosinophilic inflammation following RSV challenge; however, the roles of pulmonary eosinophilia in the antiviral response and in disease pathogenesis are inadequately understood. In vivo studies in mice with eotaxin and/or interleukin 5 (IL-5) deficiency showed that FI-RSV vaccination did not lead to enhanced pulmonary disease, where following challenge there were reduced pulmonary eosinophilia, inflammation, Th2-type cytokine responses, and altered chemokine (TARC and CCL17) responses. In contrast to wild-type mice, RSV was recovered at high titers from the lungs of eotaxin- and/or IL-5-deficient mice. Adoptive transfer of eosinophils to FI-RSV-immunized eotaxin- and IL-5-deficient (double-deficient) mice challenged with RSV was associated with potent viral clearance that was mediated at least partly through nitric oxide. These studies show that pulmonary eosinophilia has dual outcomes: one linked to RSV-induced airway inflammation and pulmonary pathology and one with innate features that contribute to a reduction in the viral load.

DOI10.1128/JVI.01536-14
CitationsScopus - 1Web of Science - 1
2015Siggs OM, Miosge LA, Daley SR, Asquith K, Foster PS, Liston A, Goodnow CC, 'Quantitative reduction of the TCR adapter protein SLP-76 unbalances immunity and immune regulation.', J Immunol, 194 2587-2595 (2015)
DOI10.4049/jimmunol.1400326Author URL
CitationsScopus - 1Web of Science - 1
2015Essilfie A-T, Horvat JC, Kim RY, Mayall JR, Pinkerton JW, Beckett EL, et al., 'Macrolide therapy suppresses key features of experimental steroid-sensitive and steroid-insensitive asthma', THORAX, 70 458-U151 (2015)
DOI10.1136/thoraxjnl-2014-206067Author URL
CitationsWeb of Science - 1
Co-authorsJodie Simpson, Jay Horvat, Philip Hansbro, Peter Gibson, Malcolm Starkey
2015Tay HL, Kaiko GE, Plank M, Li J, Maltby S, Essilfie AT, et al., 'Antagonism of miR-328 increases the antimicrobial function of macrophages and neutrophils and rapid clearance of non-typeable Haemophilus influenzae (NTHi) from infected lung.', PLoS pathogens, 11 e1004549 (2015)
DOI10.1371/journal.ppat.1004549
Co-authorsSteven Maltby, Philip Hansbro
2015Chen-Yu Hsu A, Starkey MR, Hanish I, Parsons K, Haw TJ, Howland LJ, et al., 'Targeting PI3K-p110a Suppresses Influenza Virus Infection in Chronic Obstructive Pulmonary Disease.', Am J Respir Crit Care Med, 191 1012-1023 (2015)
DOI10.1164/rccm.201501-0188OCAuthor URL
Co-authorsMalcolm Starkey, Philip Hansbro, Darryl Knight, Alan Hsu, Peter Wark
2015Li JJ, Tay HL, Maltby S, Xiang Y, Eyers F, Hatchwell L, et al., 'MicroRNA-9 regulates steroid-resistant airway hyperresponsiveness by reducing protein phosphatase 2A activity.', J Allergy Clin Immunol, (2015)
DOI10.1016/j.jaci.2014.11.044Author URL
Co-authorsSteven Maltby
2015Foo SY, Zhang V, Lalwani A, Lynch JP, Zhuang A, Lam CE, et al., 'Regulatory T cells prevent inducible BALT formation by dampening neutrophilic inflammation.', J Immunol, 194 4567-4576 (2015)
DOI10.4049/jimmunol.1400909Author URL
2015Girkin J, Hatchwell L, Foster P, Johnston SL, Bartlett N, Collison A, Mattes J, 'CCL7 and IRF-7 Mediate Hallmark Inflammatory and IFN Responses following Rhinovirus 1B Infection.', J Immunol, 194 4924-4930 (2015)
DOI10.4049/jimmunol.1401362Author URL
2015Hatchwell L, Collison A, Girkin J, Parsons K, Li J, Zhang J, et al., 'Toll-like receptor 7 governs interferon and inflammatory responses to rhinovirus and is suppressed by IL-5-induced lung eosinophilia.', Thorax, (2015)
DOI10.1136/thoraxjnl-2014-205465Author URL
Co-authorsDarryl Knight
2014Maltby S, Hansbro NG, Tay HL, Stewart J, Plank M, Donges B, et al., 'Production and differentiation of myeloid cells driven by proinflammatory cytokines in response to acute pneumovirus infection in mice.', J Immunol, 193 4072-4082 (2014) [C1]
DOI10.4049/jimmunol.1400669Author URL
Co-authorsNicole Hansbro, Steven Maltby
2014Gibson PG, Foster PS, 'Asthma 2014: from monoclonals to the microbiome.', Lancet Respir Med, 2 956-958 (2014) [C3]
DOI10.1016/S2213-2600(14)70275-9Author URL
Co-authorsPeter Gibson
2014Starkey MR, Nguyen DH, Essilfie AT, Kim RY, Hatchwell LM, Collison AM, et al., 'Tumor necrosis factor-related apoptosis-inducing ligand translates neonatal respiratory infection into chronic lung disease.', Mucosal Immunol, 7 478-488 (2014) [C1]
DOI10.1038/mi.2013.65Author URL
CitationsScopus - 1
Co-authorsMalcolm Starkey, Philip Hansbro, Jay Horvat, Joerg Mattes
2014Yang M, Eyers F, Xiang Y, Guo M, Young IG, Rosenberg HF, Foster PS, 'Expression profiling of differentiating eosinophils in bone marrow cultures predicts functional links between microRNAs and their target mRNAs', PLoS ONE, 9 (2014) [C1]

Background: MicroRNAs (miRNAs) are small non-coding RNAs that regulate complex transcriptional networks underpin immune responses. However, little is known about the specific miRNA networks that control differentiation of specific leukocyte subsets. In this study, we profiled miRNA expression during differentiation of eosinophils from bone marrow (BM) progenitors (bmEos), and correlated expression with potential mRNA targets involved in crucial regulatory functions. Profiling was performed on whole BM cultures to document the dynamic changes in miRNA expression in the BM microenvironment over the differentiation period. miRNA for network analysis were identified in BM cultures enriched in differentiating eosinophils, and chosen for their potential ability to target mRNA of factors that are known to play critical roles in eosinophil differentiation pathways or cell identify. Methodology/Principal Findings: We identified 68 miRNAs with expression patterns that were up- or down- regulated 5-fold or more during bmEos differentiation. By employing TargetScan and MeSH databases, we identified 348 transcripts involved in 30 canonical pathways as potentially regulated by these miRNAs. Furthermore, by applying miRanda and Ingenuity Pathways Analysis (IPA), we identified 13 specific miRNAs that are temporally associated with the expression of IL-5Ra and CCR3 and 14 miRNAs associated with the transcription factors GATA-1/2, PU.1 and C/EBPe. We have also identified 17 miRNAs that may regulate the expression of TLRs 4 and 13 during eosinophil differentiation, although we could identify no miRNAs targeting the prominent secretory effector, eosinophil major basic protein. Conclusions/Significance: This is the first study to map changes in miRNA expression in whole BM cultures during the differentiation of eosinophils, and to predict functional links between miRNAs and their target mRNAs for the regulation of eosinophilopoiesis. Our findings provide an important resource that will promote the platform for further understanding of the role of these non-coding RNAs in the regulation of eosinophil differentiation and function. © 2014 Yang et al.

DOI10.1371/journal.pone.0097537
CitationsScopus - 2Web of Science - 2
Co-authorsMing Yang
2014Xiang Y, Eyers F, Young IG, Rosenberg HF, Foster PS, Yang M, 'Identification of MicroRNAs regulating the developmental pathways of bone marrow derived mast cells', PLoS ONE, 9 (2014) [C1]

Background: MicroRNAs (miRNAs) play important roles in leukocyte differentiation, although those utilised for specific programs and key functions remain incompletely characterised. As a global approach to gain insights into the potential regulatory role of miRNA in mast cell differentiation we characterised expression in BM cultures from the initiation of differentiation. In cultures enriched in differentiating mast cells we characterised miRNA expression and identified miRNA targeting the mRNA of putative factors involved in differentiation pathways and cellular identity. Detailed pathway analysis identified a unique miRNA network that is intimately linked to the mast cell differentiation program. Methodology/Principal Findings: We identified 86 unique miRNAs with expression patterns that were up- or down-regulated at 5-fold or more during bone marrow derived mast cells (BMMC) development. By employing TargetScan and MeSH databases, we identified 524 transcripts involved in 30 canonical pathways as potentially regulated by these specific 86 miRNAs. Furthermore, by applying miRanda and IPA analyses, we predict that 7 specific miRNAs of this group are directly associated with the expression of c-Kit and FceRIa and likewise, that 18 miRNAs promote expression of Mitf, GATA1 and c/EBPa three core transcription factors that direct mast cell differentiation. Furthermore, we have identified 11 miRNAs that may regulate the expression of STATs-3, -5a/b, GATA2 and GATA3 during differentiation, along with 13 miRNAs that target transcripts encoding Ndst2, mMCP4 and mMCP6 and thus may regulate biosynthesis of mast cell secretory mediators. Conclusions/ Significance: This investigation characterises changes in miRNA expression in whole BM cultures during the differentiation of mast cells and predicts functional links between miRNAs and their target mRNAs for the regulation of development. This information provides an important resource for further investigations of the contributions of miRNAs to mast cell differentiation and function. © 2014 Xiang et al.

DOI10.1371/journal.pone.0098139
CitationsScopus - 5Web of Science - 4
Co-authorsMing Yang
2014Hansbro PM, Hamilton MJ, Fricker M, Gellatly SL, Jarnicki AG, Zheng D, et al., 'Importance of mast cell Prss31/transmembrane tryptase/tryptase-¿ in lung function and experimental chronic obstructive pulmonary disease and colitis', Journal of Biological Chemistry, 289 18214-18227 (2014) [C1]

Protease serine member S31 (Prss31)/transmembrane tryptase/tryptase-¿ is a mast cell (MC)-restricted protease of unknown function that is retained on the outer leaflet of the plasma membrane when MCs are activated. We determined the nucleotide sequences of the Prss31 gene in different mouse strains and then used a Cre/loxP homologous recombination approach to create a novel Prss31 -/- C57BL/6 mouse line. The resulting animals exhibited no obvious developmental abnormality, contained normal numbers of granulated MCs in their tissues, and did not compensate for their loss of the membrane tryptase by increasing their expression of other granule proteases. When Prss31-null MCs were activated with a calcium ionophore or by their high affinity IgE receptors, they degranulated in a pattern similar to that of WT MCs. Prss31-null mice had increased baseline airway reactivity to methacholine but markedly reduced experimental chronic obstructive pulmonary disease and colitis, thereby indicating both beneficial and adverse functional roles for the tryptase. In a cigarette smokeinduced model of chronic obstructive pulmonary disease, WT mice had more pulmonary macrophages, higher histopathology scores, and more fibrosis in their small airways than similarly treated Prss31-null mice. In a dextran sodium sulfate-induced acute colitis model, WT mice lost more weight, had higher histopathology scores, and contained more Cxcl-2 and IL-6 mRNA in their colons than similarly treated Prss31-null mice. The accumulated data raise the possibility that inhibitors of this membrane tryptase may provide additional therapeutic benefit in the treatment of humans with these MC-dependent inflammatory diseases. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

DOI10.1074/jbc.M114.548594
CitationsScopus - 4Web of Science - 3
Co-authorsMichael Fricker, Philip Hansbro
2014Hatchwell L, Girkin J, Morten M, Collison A, Mattes J, Foster PS, et al., 'Salmeterol attenuates chemotactic responses in rhinovirus-induced exacerbation of allergic airways disease¿by modulating protein phosphatase 2A', Journal of Allergy and Clinical Immunology, (2014) [C1]

Background: ß-Agonists are used for relief and control of asthma symptoms by reversing bronchoconstriction. They might also have anti-inflammatory properties, but the underpinning mechanisms remain poorly understood. Recently, a direct interaction between formoterol and protein phosphatase 2A (PP2A) has been described in¿vitro. Objective: We sought to elucidate the molecular mechanisms by which ß-agonists exert anti-inflammatory effects in allergen-driven and rhinovirus 1B-exacerbated allergic airways disease (AAD). Methods: Mice were sensitized and then challenged with house dust mite to induce AAD while receiving treatment with salmeterol, formoterol, or salbutamol. Mice were also infected with rhinovirus 1B to exacerbate lung inflammation and therapeutically administered salmeterol, dexamethasone, or the PP2A-activating drug (S)-2-amino-4-(4-[heptyloxy]phenyl)-2-methylbutan-1-ol (AAL[S]). Results: Systemic or intranasal administration of salmeterol protected against the development of allergen- and rhinovirus-induced airway hyperreactivity and decreased eosinophil recruitment to the lungs as effectively as dexamethasone. Formoterol and salbutamol also showed anti-inflammatory properties. Salmeterol, but not dexamethasone, increased PP2A activity, which reduced CCL11, CCL20, and CXCL2 expression and reduced levels of phosphorylated extracellular signal-regulated kinase 1 and active nuclear factor ¿B subunits in the lungs. The anti-inflammatory effect of salmeterol was blocked by targeting the catalytic subunit of PP2A with small RNA interference. Conversely, increasing PP2A activity with AAL(S) abolished rhinovirus-induced airway hyperreactivity, eosinophil influx, and CCL11, CCL20, and CXCL2 expression. Salmeterol also directly activated immunoprecipitated PP2A in¿vitro isolated from human airway epithelial cells. Conclusions: Salmeterol exerts anti-inflammatory effects by increasing PP2A activity in AAD and rhinovirus-induced lung inflammation, which might potentially account for some of its clinical benefits. © 2013 American Academy of Allergy, Asthma & Immunology.

DOI10.1016/j.jaci.2013.11.014
CitationsScopus - 5Web of Science - 4
Co-authorsNikki Verrills, Joerg Mattes, Matt Dun
2014Kumar RK, Foster PS, Rosenberg HF, 'Respiratory viral infection, epithelial cytokines, and innate lymphoid cells in asthma exacerbations', Journal of Leukocyte Biology, 96 391-396 (2014) [C1]

Exacerbations of asthma are most commonly triggered by viral infections, which amplify allergic inflammation. Cytokines released by virus-infected AECs may be important in driving this response. This review focuses on accumulating evidence in support of a role for epithelial cy-tokines, including IL-33, IL-25, and TSLP, as well as their targets, type 2 innate lymphoid cells (ILC2s), in the patho-genesis of virus-induced asthma exacerbations. Production and release of these cytokines lead to recruitment and activation of ILC2s, which secrete mediators, including IL-5 and IL-13, which augment allergic inflammation. However, little information is currently available about the induction of these responses by the respiratory viruses that are strongly associated with exacerbations of asthma, such as rhinoviruses. Further human studies, as well as improved animal experimental models, are needed to investigate appropriately the pathogenetic mechanisms in virus-induced exacerbations of asthma, including the role of ILCs. © Society for Leukocyte Biology.

DOI10.1189/jlb.3RI0314-129R
CitationsScopus - 3Web of Science - 2
2014Tay HL, Plank M, Collison A, Mattes J, Kumar RK, Foster PS, 'MicroRNA: Potential biomarkers and therapeutic targets for allergic asthma?', Annals of Medicine, 46 633-639 (2014) [C1]

MicroRNAs are small non-coding RNAs that bind to multiple target mRNAs to control gene expression post-transcriptionally by inhibiting translation. In mammalian cells, microRNAs play important roles in a diverse array of cellular processes (e.g. cell proliferation and differentiation). However, alterations in their levels may compromise cellular function, predisposing to disease. In this review, we discuss microRNAs that have been linked with pathogenesis of asthma and propose functional roles in the regulation of disease. MicroRNAs have the potential to be biomarkers for asthma and provide the platform for the development of new classes of therapeutic compounds.

DOI10.3109/07853890.2014.958196
CitationsScopus - 1Web of Science - 1
Co-authorsJoerg Mattes
2014Collison A, Li J, Pereira De Siqueira A, Zhang J, Toop HD, Morris JC, et al., 'Tumor necrosis factor-related apoptosis-inducing ligand regulates hallmark features of airways remodeling in allergic airways disease', American Journal of Respiratory Cell and Molecular Biology, 51 86-93 (2014) [C1]

Allergic asthma is a complex disease characterized by acute inflammation of the airways that over time leads to the development of significant structural changes termed remodeling. TNF-related apoptosis-inducing ligand (TRAIL) has an important regulatory role in acute allergic airways inflammation through up-regulation of the E3 ubiquitin ligase Midline-1 (MID-1), which limits protein phosphatase 2A (PP2A) activity and downstream dephosphorylation of proinflammatory signaling molecules. The relevance of TRAIL in the development of airways remodeling has yet to be determined. In this study, the lungs of wild-type (WT) BALB/c and Tnfsf10 knockout (TRAIL-/-) mice were chronically exposed to ovalbumin (OVA) for 12 weeks to induce hallmark features of chronic allergic airways disease, including airways hyperreactivity (AHR), subepithelial collagen deposition, goblet cell hyperplasia, and smooth muscle hypertrophy. TRAIL-/- mice were largely protected from the development of AHR and peribronchial eosinophilia and had reduced levels of mast cells in the airways. This correlated with lower levels of cytokines, including IL-4, -5, -10, and -13, and with lower levels of proinflammatory chemokines from cultured cells isolated from the draining lymph nodes. TRAIL-/- mice were also protected from the characteristic features of airways remodeling, including peribronchial fibrosis, smooth muscle hypertrophy, and mucus hypersecretion, which correlated with reduced TGF-ß1 levels in the lungs. MID-1 expression was reduced in TRAIL-/- mice and up-regulated in allergic WT mice. Raising PP2A activity using 2-amino-4-(4-heptyloyphenol)-2-methylbutan-1-ol in allergic WT mice reduced eosinophilia, TGF-ß1, and peribronchial fibrosis. This study shows that TRAIL promotes airways remodeling in an OVA-induced model of chronic allergic airways disease. Targeting TRAIL and its downstream proin flammatory signaling pathway involving PP2A may be of therapeutic bene fit in reducing the hallmark features of airways remodeling observed in chronic allergic airways inflammation. Copyright © 2014 by the American Thoracic Society.

DOI10.1165/rcmb.2013-0490OC
CitationsScopus - 4Web of Science - 4
Co-authorsJoerg Mattes
2013Eftekhari P, Hajizadeh S, Reza Raoufy M, Reza Masjedi M, Yang M, Hansbro N, et al., 'Preventive effect of N-acetylcysteine in a mouse model of steroid resistant acute exacerbation of asthma', EXCLI Journal, 12 184-192 (2013) [C1]

Oxidative stress appears to have an important role in glucocorticoid insensitivity, as a crucial problem in asthma therapy. We studied the preventive effect of antioxidant N-acetylcysteine (NAC) on the airway hyper-responsiveness (AHR) and the accumulation of inflammatory cells in the airways in an animal model of steroid resistant acute exacerbation of asthma. Systemically sensitized Balb/C mice were exposed to Ovalbumin aerosol on days 13, 14, 15 and 16, followed by intratracheal lipopolysaccharide (LPS) to induce acute exacerbation. NAC (intraperitoneal, 320 mg/kg 30 min before and 12 hours after each challenge) reduced hyperresponsiveness with/out dexamethasone. LPS application caused neutrophilia in bronchoalveolar lavage fluid (BALF) and eosinophil count was higher than respective control in BALF as well as neutrophils after dexamethasone treatment. NAC significantly decreased neutrophil and eosinophil count in BALF as well as inflammatory cytokines (IL-13 and IL-5).We concluded that addition of NAC to asthma therapy has beneficial preventive effects in an animal model of steroid resistant acute exacerbation of asthma.

CitationsScopus - 1Web of Science - 1
Co-authorsNicole Hansbro, Ming Yang
2013de Souza Alves CC, Collison A, Hatchwell L, Plank M, Morten M, Foster PS, et al., 'Inhibiting AKT phosphorylation employing non-cytotoxic anthraquinones ameliorates TH2 mediated allergic airways disease and rhinovirus exacerbation.', PLoS One, 8 e79565 (2013) [C1]
DOI10.1371/journal.pone.0079565Author URL
CitationsScopus - 2Web of Science - 1
Co-authorsJoerg Mattes
2013Kaiko G, Loh Z, Spann K, Lynch J, Lalwani A, Davidson S, et al., 'TLR7 gene deficiency and early-life pneumovirus infection interact to predispose toward the development of asthma-like pathology in mice', EUROPEAN RESPIRATORY JOURNAL, 42 (2013)
Author URL
2013Hansbro P, Beckett E, Stevens R, Jarnicki A, Wark P, Foster P, 'A short-term model of COPD identifies a role for mast cell tryptase', EUROPEAN RESPIRATORY JOURNAL, 42 (2013)
Author URL
Co-authorsPeter Wark, Philip Hansbro
2013Thorburn AN, Brown AC, Nair PM, Chevalier N, Foster PS, Gibson PG, Hansbro PM, 'Pneumococcal Components Induce Regulatory T Cells That Attenuate the Development of Allergic Airways Disease by Deviating and Suppressing the Immune Response to Allergen', JOURNAL OF IMMUNOLOGY, 191 4112-4120 (2013) [C1]
DOI10.4049/jimmunol.1201232Author URL
CitationsScopus - 4Web of Science - 3
Co-authorsPhilip Hansbro, Peter Gibson
2013Kaiko GE, Loh Z, Spann K, Lynch JP, Lalwani A, Zheng Z, et al., 'Toll-like receptor 7 gene deficiency and early-life Pneumovirus infection interact to predispose toward the development of asthma-like pathology in mice', JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 131 1331-U132 (2013) [C1]
DOI10.1016/j.jaci.2013.02.041Author URL
CitationsScopus - 19Web of Science - 18
Co-authorsKatherine Baines, Jodie Simpson
2013Beckett EL, Stevens RL, Jarnicki AG, Kim RY, Hanish I, Hansbro NG, et al., 'A new short-term mouse model of chronic obstructive pulmonary disease identifies a role for mast cell tryptase in pathogenesis', The Journal of Allergy and Clinical Immunology, 131 752-762 (2013) [C1]
CitationsScopus - 29Web of Science - 30
Co-authorsPhilip Hansbro, Nicole Hansbro, Simon Keely, Jay Horvat, Peter Wark, Ming Yang
2013Foster PS, Plank MW, Collison AM, Tay HL, Kaiko GE, Li J, et al., 'The emerging role of microRNAs in regulating immune and inflammatory responses in the lung', Immunological Reviews, 253 198-215 (2013) [C1]
CitationsScopus - 8Web of Science - 11
Co-authorsMing Yang, Philip Hansbro, Joerg Mattes
2013Barry J, Loh Z, Collison A, Mazzone S, Lalwani A, Zhang V, et al., 'Absence of Toll-IL-1 Receptor 8/Single Immunoglobulin IL-1 Receptor-Related Molecule Reduces House Dust Mite-Induced Allergic Airway Inflammation in Mice', AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 49 481-490 (2013) [C1]
DOI10.1165/rcmb.2012-0425OCAuthor URL
CitationsScopus - 2Web of Science - 2
Co-authorsJoerg Mattes
2013Collison AM, Hatchwell LM, Verrills NM, Wark PA, Pereira De Siqueira AL, Tooze MK, et al., 'The E3 ubiquitin ligase midline 1 promotes allergen and rhinovirus-induced asthma by inhibiting protein phosphatase 2A activity', Nature Medicine, 19 232-237 (2013) [C1]
CitationsScopus - 32Web of Science - 27
Co-authorsNikki Verrills, Peter Wark, Joerg Mattes
2013Hansbro PM, Scott GV, Essilfie A-T, Kim RY, Starkey MR, Nguyen D, et al., 'Th2 cytokine antagonists: Potential treatments for severe asthma', Expert Opinion on Investigational Drugs, 22 49-69 (2013) [C1]
CitationsScopus - 18Web of Science - 13
Co-authorsMalcolm Starkey, Ming Yang, Philip Hansbro, Jay Horvat
2013Starkey MR, Jarnicki AG, Essilfie A-T, Gellatly SL, Kim RY, Brown AC, et al., 'Murine models of infectious exacerbations of airway inflammation', CURRENT OPINION IN PHARMACOLOGY, 13 337-344 (2013) [C1]
DOI10.1016/j.coph.2013.03.005Author URL
CitationsScopus - 6Web of Science - 7
Co-authorsMalcolm Starkey, Philip Hansbro, Jay Horvat
2013Rosenberg HF, Dyer KD, Foster PS, 'Eosinophils: changing perspectives in health and disease', NATURE REVIEWS IMMUNOLOGY, 13 9-22 (2013) [C1]
DOI10.1038/nri3341Author URL
CitationsScopus - 97Web of Science - 93
2013Rosenberg HF, Foster PS, 'Eosinophil cytolysis and release of cell-free granules', NATURE REVIEWS IMMUNOLOGY, 13 (2013) [C3]
DOI10.1038/nri3341-c2Author URL
2013Collison A, Siegle JS, Hansbro NG, Kwok C-T, Herbert C, Mattes J, et al., 'Epigenetic changes associated with disease progression in a mouse model of childhood allergic asthma', DISEASE MODELS & MECHANISMS, 6 993-1000 (2013) [C1]
DOI10.1242/dmm.011247Author URL
CitationsScopus - 4Web of Science - 4
Co-authorsNicole Hansbro, Joerg Mattes
2013Herbert C, Siegle JS, Shadie AM, Nikolaysen S, Garthwaite L, Hansbro NG, et al., 'Development of asthmatic inflammation in mice following early-life exposure to ambient environmental particulates and chronic allergen challenge', DMM Disease Models and Mechanisms, 6 479-488 (2013) [C1]
CitationsScopus - 9Web of Science - 9
Co-authorsNicole Hansbro
2013Li JJ, Tay HL, Plank M, Essilfie A-T, Hansbro PM, Foster PS, Yang M, 'Activation of Olfactory Receptors on Mouse Pulmonary Macrophages Promotes Monocyte Chemotactic Protein-1 Production', PLOS ONE, 8 (2013) [C1]
DOI10.1371/journal.pone.0080148Author URL
CitationsScopus - 2Web of Science - 1
Co-authorsMing Yang, Philip Hansbro
2013Starkey MR, Essilfie A-T, Horvat JC, Kim RY, Nguyen DH, Beagley KW, et al., 'Constitutive production of IL-13 promotes early-life Chlamydia respiratory infection and allergic airway disease', Mucosal Immunology, 6 569-579 (2013) [C1]
CitationsScopus - 8Web of Science - 4
Co-authorsJay Horvat, Malcolm Starkey, Philip Hansbro, Joerg Mattes
2012Thorburn AN, Foster PS, Gibson PG, Hansbro PM, 'Components of streptococcus pneumoniae suppress allergic airways disease and NKT cells by inducing regulatory T cells', The Journal of Immunology, 188 4611-4620 (2012) [C1]
CitationsScopus - 23Web of Science - 19
Co-authorsPhilip Hansbro, Peter Gibson
2012Essilfie A-T, Simpson JL, Dunkley ML, Morgan LC, Oliver BG, Gibson PG, et al., 'Combined haemophilus influenzae respiratory infection and allergic airways disease drives chronic infection and features of neutrophilic asthma', Thorax, 67 588-599 (2012) [C1]
CitationsScopus - 32Web of Science - 29
Co-authorsMargaret Dunkley, Philip Hansbro, Peter Gibson, Jodie Simpson
2012Munitz A, Foster PS, 'T(H)9 cells: In front and beyond T(H)2', Journal of Allergy and Clinical Immunology, 129 1011-1013 (2012) [C3]
CitationsScopus - 2Web of Science - 2
2012Yang M, Kumar RK, Hansbro PM, Foster PS, 'Emerging roles of pulmonary macrophages in driving the development of severe asthma', Journal of Leukocyte Biology, 91 557-569 (2012) [C1]
CitationsScopus - 19Web of Science - 18
Co-authorsMing Yang, Philip Hansbro
2012Kumar RK, Foster PS, 'Are mouse models of asthma appropriate for investigating the pathogenesis of airway hyper-responsiveness?', Frontiers in Physiology, 3 1-7 (2012) [C1]
DOI10.3389/fphys.2012.00312
CitationsScopus - 10Web of Science - 8
2012Kumar RK, Yang M, Herbert C, Foster PS, 'Interferon-¿, pulmonary macrophages and airway responsiveness in asthma', Inflammation and Allergy - Drug Targets, 11 292-297 (2012) [C1]
CitationsScopus - 6
Co-authorsMing Yang
2012Beckett EL, Phipps S, Starkey MR, Horvat JC, Beagley KW, Foster PS, Hansbro PM, 'TLR2, but not TLR4, is required for effective host defence against chlamydia respiratory tract infection in early life', PLOS One, 7 e39460 (2012) [C1]
CitationsScopus - 17Web of Science - 16
Co-authorsPhilip Hansbro, Malcolm Starkey, Jay Horvat
2012Hansbro PM, Starkey MR, Kim RY, Stevens RL, Foster PS, Horvat JC, 'Programming of the lung by early-life infection', Journal of Developmental Origins of Health and Disease, 3 153-158 (2012) [C1]
CitationsScopus - 4Web of Science - 4
Co-authorsJay Horvat, Philip Hansbro, Malcolm Starkey
2011Collison AM, Herbert C, Siegle JS, Mattes J, Foster PS, Kumar RK, 'Altered expression of microRNA in the airway wall in chronic asthma: miR-126 as a potential therapeutic target', BMC Pulmonary Medicine, 11 29 (2011) [C1]
CitationsScopus - 39Web of Science - 34
Co-authorsJoerg Mattes
2011Kaiko GE, Foster PS, 'New insights into the generation of Th2 immunity and potential therapeutic targets for the treatment of asthma', Current Opinion in Allergy and Clinical Immunology, 11 39-45 (2011) [C1]
DOI10.1097/aci.0b013e328342322f
CitationsScopus - 28Web of Science - 27
2011Essilfie A-T, Simpson JL, Horvat JC, Preston JA, Dunkley ML, Foster PS, et al., 'Haemophilus influenzae infection drives IL-17-mediated neutrophilic allergic airways disease', PLoS Pathogens, 7 e1002244 (2011) [C1]
Co-authorsPeter Gibson, Jay Horvat, Jodie Simpson, Philip Hansbro, Margaret Dunkley
2011Asquith KL, Horvat JC, Kaiko GE, Carey AJ, Beagley KW, Hansbro PM, Foster PS, 'Interleukin-13 promotes susceptibility to chlamydial infection of the respiratory and genital tracts', PLoS Pathogens, 7 e1001339 (2011) [C1]
CitationsScopus - 24Web of Science - 20
Co-authorsJay Horvat, Philip Hansbro
2011Wang W, Hansbro PM, Foster PS, Yang M, 'An alternate STAT6-independent pathway promotes eosinophil influx into blood during allergic airway inflammation', PLoS ONE, 6 e17766 (2011) [C1]
DOI10.1371/journal.pone.0017766
CitationsScopus - 7Web of Science - 6
Co-authorsPhilip Hansbro, Ming Yang
2011Hansbro PM, Kaiko GE, Foster PS, 'Cytokine/anti-cytokine therapy - Novel treatments for asthma?', British Journal of Pharmacology, 163 81-95 (2011) [C2]
DOI10.1111/j.1476-5381.2011.01219.x
CitationsScopus - 48Web of Science - 42
Co-authorsPhilip Hansbro
2011Siegle JS, Hansbro NG, Dong C, Angkasekwinai P, Foster PS, Kumar RK, 'Blocking induction of T helper type 2 responses prevents development of disease in a model of childhood asthma', Clinical and Experimental Immunology, 165 19-28 (2011) [C1]
DOI10.1111/j.1365-2249.2011.04392.x
CitationsScopus - 17Web of Science - 18
Co-authorsNicole Hansbro
2011Wu D, Ahrens R, Osterfeld H, Noah TK, Groschwitz K, Foster PS, et al., 'Interleukin-13 (IL-13)/IL-13 receptor1 (IL-13R1) signaling regulates intestinal epithelial cystic fibrosis transmembrane conductance regulator channel-dependent Cl- secretion', Journal of Biological Chemistry, 286 13357-13369 (2011) [C1]
CitationsScopus - 13Web of Science - 9
2011Davidson SK, Kaiko GE, Loh Z, Lalwani A, Zhang V, Spann K, et al., 'Plasmacytoid Dendritic Cells promote host defense against Acute Pneumovirus infection via the TLR7-MyD88-Dependent signaling pathway', Journal of Immunology, 186 5938-5948 (2011) [C1]
DOI10.4049/jimmunol.1002635
CitationsScopus - 33Web of Science - 33
Co-authorsNicole Hansbro
2011Lousberg EL, Diener KR, Fraser CK, Phipps S, Foster PS, Chen W, et al., 'Antigen-specific T-Cell responses to a recombinant fowlpox virus are dependent on MyD88 and Interleukin-18 and Independent of Toll-Like Receptor 7 (TLR7)- and TLR9-Mediated innate immune recognition', Journal of Virology, 85 3385-3396 (2011) [C1]
DOI10.1128/jvi.02000-10
CitationsScopus - 6Web of Science - 6
2011Collison AM, Mattes J, Plank MW, Foster PS, 'Inhibition of house dust mite-induced allergic airways disease by antagonism of microRNA-145 is comparable to glucocorticoid treatment', Journal of Allergy and Clinical Immunology, 128 160-U251 (2011) [C1]
CitationsScopus - 70Web of Science - 58
Co-authorsJoerg Mattes
2011Preston JA, Thorburn AN, Starkey MR, Beckett EL, Horvat JC, Wade MA, et al., 'Streptococcus pneumoniae infection suppresses allergic airways disease by inducing regulatory T-cells', European Respiratory Journal, 37 53-64 (2011) [C1]
DOI10.1183/09031936.00049510
CitationsScopus - 31Web of Science - 29
Co-authorsPhilip Hansbro, Peter Gibson, Jay Horvat, Malcolm Starkey
2011Hazlewood LC, Wood LG, Hansbro PM, Foster PS, 'Dietary lycopene supplementation suppresses Th2 responses and lung eosinophilia in a mouse model of allergic asthma', Journal of Nutritional Biochemistry, 22 95-100 (2011) [C1]
DOI10.1016/j.jnutbio.2009.12.003
CitationsScopus - 18Web of Science - 15
Co-authorsPhilip Hansbro, Lisa Wood
2010Lau JY, Oliver BG, Baraket M, Beckett EL, Hansbro NG, Moir LM, et al., 'Fibulin-1 Is increased in asthma - A novel mediator of airway remodeling?', Plos One, 5 1-13 (2010) [C1]
DOI10.1371/journal.pone.0013360
CitationsScopus - 15Web of Science - 12
Co-authorsPhilip Hansbro, Nicole Hansbro
2010Herbert C, Scott MM, Scruton KH, Keogh RP, Yuan KC, Hsu K, et al., 'Alveolar macrophages stimulate enhanced cytokine production by pulmonary CD4+ T-lymphocytes in an exacerbation of murine chronic asthma', American Journal of Pathology, 177 1657-1664 (2010) [C1]
DOI10.2353/ajpath.2010.100019
CitationsScopus - 21Web of Science - 19
2010Horvat JC, Starkey MR, Kim RY, Beagley KW, Preston JA, Gibson PG, et al., 'Chlamydial respiratory infection during allergen sensitization drives neutrophilic allergic airways disease', Journal of Immunology, 184 4159-4169 (2010) [C1]
DOI10.4049/jimmunol.0902287
CitationsScopus - 40Web of Science - 35
Co-authorsMalcolm Starkey, Peter Gibson, Jay Horvat, Philip Hansbro
2010Kaiko GE, Phipps S, Angkasekwinai P, Dong C, Foster PS, 'NK cell deficiency predisposes to viral-induced Th2-type allergic inflammation via epithelial-derived IL-25', Journal of Immunology, 185 4681-4690 (2010) [C1]
DOI10.4049/jimmunol.1001758
CitationsScopus - 47Web of Science - 45
2010Li J, Wang W, Baines KJ, Bowden NA, Hansbro PM, Gibson PG, et al., 'IL-27/IFN-y induce MyD88-dependent steroid-resistant airway hyperresponsiveness by inhibiting glucocorticoid signaling in macrophages', Journal of Immunology, 185 4401-4409 (2010) [C1]
DOI10.4049/jimmunol.1001039
CitationsScopus - 35Web of Science - 32
Co-authorsPeter Gibson, Katherine Baines, Ming Yang, Philip Hansbro, Nikola Bowden
2010Thorburn AN, O'Sullivan BJ, Thomas R, Kumar RK, Foster PS, Gibson PG, Hansbro PM, 'Pneumococcal conjugate vaccine-induced regulatory T cells suppress the development of allergic airways disease', Thorax, 65 1053-1060 (2010) [C1]
DOI10.1136/thx.2009.131508
CitationsScopus - 29Web of Science - 28
Co-authorsPeter Gibson, Philip Hansbro
2010Horvat JC, Starkey MR, Kim RY, Phipps S, Gibson PG, Beagley KW, et al., 'Early-life chlamydial lung infection enhances allergic airways disease through age-dependent differences in immunopathology', Journal of Allergy and Clinical Immunology, 125 617-625 (2010) [C1]
DOI10.1016/j.jaci.2009.10.018
Co-authorsMalcolm Starkey, Jay Horvat, Peter Gibson, Philip Hansbro
2010Hutchinson MR, Loram LC, Zhang Y, Shridhar M, Rezvani N, Berkelhammer D, et al., 'Evidence that tricyclic small molecules may possess toll-like receptor and myeloid differentiation protein 2 activity', Neuroscience, 168 551-563 (2010) [C1]
DOI10.1016/j.neuroscience.2010.03.067
CitationsScopus - 39Web of Science - 36
2010Yang M, Kumar RK, Foster PS, 'Interferon-Y and pulmonary macrophages contribute to the mechanisms underlying prolonged airway hyperresponsiveness', Clinical and Experimental Allergy, 40 163-173 (2010) [C1]
DOI10.1111/j.1365-2222.2009.03393.x
CitationsScopus - 16Web of Science - 12
Co-authorsMing Yang
2010Wood LG, Hazlewood LC, Foster PS, Hansbro PM, 'Lyprinol reduces inflammation and improves lung function in a mouse model of allergic airways disease', Clinical and Experimental Allergy, 40 1785-1793 (2010) [C1]
DOI10.1111/j.1365-2222.2010.03503.x
CitationsScopus - 8Web of Science - 7
Co-authorsLisa Wood, Philip Hansbro
2010Burgess JK, Boustany S, Moir LM, Weckmann M, Lau JY, Grafton K, et al., 'Reduction of tumstatin in asthmatic airways contributes to angiogenesis, inflammation, and hyperresponsiveness', American Journal of Respiratory and Critical Care Medicine, 181 106-115 (2010) [C1]
DOI10.1164/rccm.200904-0631oc
CitationsScopus - 21Web of Science - 18
Co-authorsNicole Hansbro, Philip Hansbro
2010Wang W, Li J, Foster PS, Hansbro PM, Yang M, 'Potential therapeutic targets for steroid-resistant asthma', Current Drug Targets, 11 957-970 (2010) [C1]
DOI10.2174/138945010791591412
CitationsScopus - 25Web of Science - 24
Co-authorsMing Yang, Philip Hansbro
2010Siegle JS, Hansbro NG, Herbert C, Rosenberg HF, Domachowske JB, Asquith KL, et al., 'Early-life viral infection and allergen exposure interact to induce an asthmatic phenotype in mice', Respiratory Research, 11 1-15 (2010) [C1]
DOI10.1186/1465-9921-11-14
CitationsScopus - 44Web of Science - 41
Co-authorsNicole Hansbro
2009Kumar RK, Hitchins MP, Foster PS, 'Epigenetic changes in childhood asthma', Disease Models and Mechanisms: DMM, 2 549-553 (2009) [C1]
DOI10.1242/dmm.001719
CitationsScopus - 14Web of Science - 10
2009Yang M, Kumar RK, Foster PS, 'Pathogenesis of steroid-resistant airway hyperresponsiveness: Interaction between IFN-gamma and TLR4/MyD88 pathways', Journal of Immunology, 182 5107-5115 (2009) [C1]
DOI10.4049/jimmunol.0803468
CitationsScopus - 38Web of Science - 30
Co-authorsMing Yang
2009Percopo CM, Qiu Z, Phipps S, Foster PS, Domachowske JB, Rosenberg HF, 'Pulmonary eosinophils and their role in immunopathologic responses to formalin-inactivated pneumonia virus of mice', Journal of Immunology, 183 604-612 (2009) [C1]
DOI10.4049/jimmunol.0802270
CitationsScopus - 15Web of Science - 13
2009Cai Y, Kumar RK, Zhou J, Foster PS, Webb DC, 'Ym1/2 promotes Th2 cytokine expression by inhibiting 12/15(S)-lipoxygenase: Identification of a novel pathway for regulating allergic inflammation', Journal of Immunology, 182 5393-5399 (2009) [C1]
DOI10.4049/jimmunol.0803874
CitationsScopus - 36Web of Science - 33
2009Mattes J, Collison AM, Plank MW, Phipps S, Foster PS, 'Antagonism of microRNA-126 suppresses the effector function of T(H)2 cells and the development of allergic airways disease', Proceedings of the National Academy of Sciences of the United States of America, 106 18704-18709 (2009) [C1]
DOI10.1073/pnas.0905063106
CitationsScopus - 159Web of Science - 151
Co-authorsJoerg Mattes
2009Knott ML, Matthaei KI, Foster PS, Dent LA, 'The roles of eotaxin and the STAT6 signalling pathway in eosinophil recruitment and host resistance to the nematodes Nippostrongylus brasiliensis and Heligmosomoides bakeri', Molecular Immunology, 46 2714-2722 (2009) [C1]
DOI10.1016/j.molimm.2009.05.016
CitationsScopus - 17Web of Science - 16
2009Collison AM, Foster PS, Mattes J, 'Emerging role of tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) as a key regulator of inflammatory responses', Clinical and Experimental Pharmacology and Physiology, 36 1049-1053 (2009) [C1]
DOI10.1111/j.1440-1681.2009.05258.x
CitationsScopus - 25Web of Science - 27
Co-authorsJoerg Mattes
2009Bertram CM, Misso NL, Fogel-Petrovic M, Figueroa CD, Foster PS, Thompson PJ, Bhoola KD, 'Expression of kinin receptors on eosinophils: Comparison of asthmatic patients and healthy subjects', Journal of Leukocyte Biology, 85 544-552 (2009) [C1]
DOI10.1189/jlb.0508283
CitationsScopus - 12Web of Science - 11
2009Foster PS, Mattes J, 'IL-21 comes of age', Immunology and Cell Biology, 87 359-360 (2009) [C2]
DOI10.1038/icb.2009.33
Co-authorsJoerg Mattes
2009Phipps S, Hansbro NG, Lam CE, Foo A, Matthaei KI, Foster PS, 'Allergic sensitization is enhanced in early life through toll-like receptor 7 activation', Clinical and Experimental Allergy, 39 1920-1928 (2009) [C1]
DOI10.1111/j.1365-2222.2009.03335.x
CitationsScopus - 10Web of Science - 9
Co-authorsNicole Hansbro
2009Phipps S, Lam CE, Kaiko GE, Foo A, Collison AM, Mattes J, et al., 'Toll/IL-1 signaling is critical for house dust mite-specific Th1 and Th2 responses', American Journal of Respiratory and Critical Care Medicine, 179 883-893 (2009) [C1]
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CitationsScopus - 91Web of Science - 92
Co-authorsJoerg Mattes
2009De Vries A, Hazlewood LC, Fitch PM, Seckl JR, Foster PS, Howie SEM, 'High-fat feeding redirects cytokine responses and decreases allergic airway eosinophilia', Clinical & Experimental Allergy, 39 731-739 (2009) [C1]
DOI10.1111/j.1365-2222.2008.03179.x
CitationsScopus - 19Web of Science - 17
2008Ito K, Herbert C, Siegle JS, Vuppusetty C, Hansbro NG, Thomas PS, et al., 'Steroid-resistant neutrophilic inflammation in a mouse model of an acute exacerbation of asthma', American Journal of Respiratory Cell and Molecular Biology, 39 543-550 (2008) [C1]
DOI10.1165/rcmb.2008-0028oc
CitationsScopus - 57Web of Science - 50
Co-authorsNicole Hansbro
2008Zhou J, Wolf CR, Henderson CJ, Cai Y, Board PG, Foster PS, Webb DC, 'Glutathione transferase P1: An endogenous inhibitor of allergic responses in a mouse model of asthma', American Journal of Respiratory and Critical Care Medicine, 178 1202-1210 (2008) [C1]
DOI10.1164/rccm.200801-178oc
CitationsScopus - 16Web of Science - 15
2008Foster PS, Hogan SP, Rosenberg HF, Moqbel R, PHIPPS S, Lacy P, et al., 'Eosinophils: Biological properties and role in health and disease', Clinical and Experimental Allergy, 38 709-750 (2008) [C1]
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CitationsScopus - 309
2008Kumar RK, Herbert C, Foster PS, 'The 'classical' ovalbumin challenge model of asthma in mice', Current Drug Targets, 9 485-494 (2008) [C1]
DOI10.2174/138945008784533561
CitationsScopus - 66Web of Science - 59
2008Mattes J, Collison AM, Foster PS, 'Emerging role of microRNAs in disease pathogenesis and strategies for therapeutic modulation', Current Opinion in Molecular Therapeutics, 10 150-157 (2008) [C1]
CitationsScopus - 35Web of Science - 32
Co-authorsJoerg Mattes
2008Foster PS, Rosenberg HF, Asquith KL, Kumar RK, 'Targeting eosinophils in asthma', Current Molecular Medicine, 8 585-590 (2008) [C1]
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CitationsScopus - 16Web of Science - 15
2008Forbes EE, Groschwitz K, Abonia JP, Brandt EB, Cohen E, Blanchard C, et al., 'IL-9-and mast cell-mediated intestinal permeability predisposes to oral antigen hypersensitivity', Journal of Experimental Medicine, 205 897-913 (2008) [C1]
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CitationsScopus - 115Web of Science - 104
2008Gantier MP, Tong S, Behlke MA, Xu D, Phipps S, Foster PS, Williams BRG, 'TLR7 is involved in sequence-specific sensing of single-stranded RNAs in human macrophages', Journal of Immunology, 180 2117-2124 (2008) [C1]
CitationsScopus - 51Web of Science - 49
2008Kaiko GE, Phipps S, Hickey DK, Lam CE, Hansbro PM, Foster PS, Beagley KW, 'Chlamydia muridarum infection subverts dendritic cell function to promote Th2 immunity and airways hyperreactivity', Journal of Immunology, 180 2225-2232 (2008) [C1]
CitationsScopus - 30Web of Science - 29
Co-authorsPhilip Hansbro
2008Asquith KL, Ramshaw HS, Hansbro PM, Beagley KW, Lopez AF, Foster PS, 'The IL-3/IL-5/GM-CSF common beta receptor plays a pivotal role in the regulation of Th2 immunity and allergic airway inflammation', Journal of Immunology, 180 1199-1206 (2008) [C1]
CitationsScopus - 58Web of Science - 57
Co-authorsPhilip Hansbro
2008Herbert C, Hettiaratchi A, Webb DC, Thomas PS, Foster PS, Kumar RK, 'Suppression of cytokine expression by roflumilast and dexamethasone in a model of chronic asthma', Clinical and Experimental Allergy, 38 847-856 (2008) [C1]
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CitationsScopus - 35Web of Science - 32
2007Tumes DJ, Cormie J, Calvert MG, Stewart K, Nassenstein C, Braun A, et al., 'Strain-dependent resistance to allergen-induced lung pathophysiology in mice correlates with rate of apoptosis of lung-derived eosinophils', Journal of Leukocyte Biology, 81 1362-1373 (2007) [C1]
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CitationsScopus - 21Web of Science - 21
2007Bertram CM, Baltic S, Misso NL, Bhoola KD, Foster PS, Thompson PJ, Fogel-Petrovic M, 'Expression of kinin B1 and B2 receptors in immature, monocyte-derived dendritic cells and bradykinin-mediated increase in intracellular Ca2+ and cell migration', Journal of Leukocyte Biology, 81 1445-1454 (2007) [C1]
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CitationsScopus - 28Web of Science - 26
2007Phipps S, Lam CE, Foster PS, Matthaei KI, 'The contribution of toll-like receptors to the pathogenesis of asthma', Immunology and Cell Biology, 85 463-470 (2007) [C1]
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CitationsScopus - 21Web of Science - 20
2007Mattes J, Yang M, Foster PS, 'Regulation of microRNA by antagomirs: a new class of pharmacological antagonists for the specific regulation of gene function?', American Journal of Respiratory and Cellular Molecular Biology, 36 8-12 (2007) [C1]
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Co-authorsJoerg Mattes, Ming Yang
2007Horvat JC, Beagley KW, Wade MA, Preston JA, Hansbro NG, Hickey DK, et al., 'Neonatal chlamydial infection induces mixed T-cell responses that drive allergic airway disease', American Journal of Respiratory and Critical Care Medicine, 176 556-564 (2007) [C1]
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CitationsScopus - 45Web of Science - 44
Co-authorsJay Horvat, Philip Hansbro, Nicole Hansbro, Peter Gibson
2007Weckmann M, Collison A, Simpson JL, Kopp MV, Wark PA, Smyth MJ, et al., 'Critical link between TRAIL and CCL20 for the activation of T(H)2 cells and the expression of allergic airway disease', Nature Medicine, 13 1308-1315 (2007) [C1]
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CitationsScopus - 61Web of Science - 59
Co-authorsPeter Wark, Nicole Hansbro, Jodie Simpson, Joerg Mattes, Peter Gibson
2007Fogel-Petrovic M, Long JA, Misso NL, Foster PS, Bhoola KD, Thompson PJ, 'Physiological concentrations of transforming growth factor Beta1 selectively inhibit human dendritic cell function', International Immunopharmacology, 7 1924-1933 (2007) [C1]
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CitationsScopus - 24Web of Science - 22
2007Phipps S, Lam CE, Mahalingam S, Newhouse M, Ramirez R, Rosenberg HF, et al., 'Eosinophils contribute to innate antiviral immunity and promote clearance of respiratory syncytial virus', Blood, 110 1578-1586 (2007) [C1]
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CitationsScopus - 104Web of Science - 97
2007Knott ML, Matthaei KI, Giacomin PR, Wang H, Foster PS, Dent LA, 'Impaired resistance in early secondary Nippostrongylus brasiliensis infections in mice with defective eosinophilopoeisis', International Journal for Parasitology, 37 1367-1378 (2007) [C1]
DOI10.1016/j.ijpara.2007.04.006
CitationsScopus - 42Web of Science - 41
2007Simson L, Ellyard JI, Dent LA, Matthaei KI, Rothenberg ME, Foster PS, et al., 'Regulation of carcinogenesis by IL-5 and CCL11: A potential role for eosinophils in tumor immune surveillance', JOURNAL OF IMMUNOLOGY, 178 4222-4229 (2007)
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CitationsScopus - 65Web of Science - 64
2007Webb DC, Yang M, Matthaei (Ext) K, Foster PS, 'Comparative roles of IL-4, IL-13, and IL-4Ralpha in dendritic cell maturation and CD4+ Th2 cell function', Journal of Immunology, 178 219-227 (2007) [C1]
CitationsScopus - 43Web of Science - 42
Co-authorsMing Yang
2007Dyer KD, Czapiga M, Foster B, Foster PS, Kang EM, Lappas CM, et al., 'Eosinophils from lineage-ablated Delta dblGATA bone marrow progenitors: The dblGATA enhancer in the promoter of GATA-1 is not essential for differentiation ex vivo', Journal of Immunology, 179 1693-1699 (2007) [C1]
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2007Rosenberg HF, Phipps S, Foster PS, 'Eosinophil trafficking in allergy and asthma', Journal of Allergy and Clinical Immunology, 119 1303-1310 (2007) [C1]
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2007Preston JA, Essilfie AT, Horvat JC, Wade MA, Beagley KW, Gibson PG, et al., 'Inhibition of allergic airways disease by immunomodulatory therapy with whole killed Streptococcus pneumoniae', Vaccine, 25 8154-8162 (2007) [C1]
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Co-authorsPhilip Hansbro, Peter Gibson, Jay Horvat
2006Yang M, Rangasamy D, Matthaei KI, Frew AJ, Zimmmermann N, Mahalingam S, et al., 'Inhibition of arginase I activity by RNA interference attenuates IL-13-induced airways hyperresponsiveness', Journal of Immunology, 177 5595-5603 (2006) [C1]
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Co-authorsMing Yang
2006Forbes E, Hulett M, Ahrens R, Wagner N, Smart V, Matthaei (Ext) K, et al., 'ICAM-1-dependent pathways regulate colonic eosinophilic inflammation', Journal of Leukocyte Biology, 80 330-341 (2006) [C1]
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2006Prescott VE, Forbes E, Foster PS, Matthaei (Ext) K, Hogan SP, 'Mechanistic analysis of experimental food allergen-induced cutaneous reactions', Journal of Leukocyte Biology, 80 258-266 (2006) [C1]
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CitationsScopus - 13Web of Science - 10
2006Bystrom J, Dyer KD, Ravin S, Naumann N, Stephany DA, Foster PS, et al., 'Interleukin-5 does not influence differential transcription of transmembrane and soluble isoforms of IL-5R alpha in vivo', European Journal of Haematology, 77 181-190 (2006) [C1]
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CitationsScopus - 6Web of Science - 6
2006Sharkhuu T, Matthaei KI, Forbes E, Mahalingam S, Hogan SP, Hansbro PM, Foster PS, 'Mechanism of interleukin-25 (IL-17E)-induced pulmonary inflammation and airways hyper-reactivity', Clinical and Experimental Allergy, 36 1575-1583 (2006) [C1]
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Co-authorsPhilip Hansbro
2006Yang M, Rangasamy D, Matthaei K, Frew A, Zimmmermann N, Mahalingham S, et al., 'Inhibition of arginase I activity by RNA interference attenuates interleukin-13 induced airways hyperresponsiveness', ACTA PHARMACOLOGICA SINICA, 27 266-266 (2006)
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Co-authorsMing Yang
2006Yang M, Mattes J, Hansbro PM, Foster PS, 'Employment of microRNA profiles and RNA interference and antagomirs for the characterization and treatment of respiratory disease', Drug Discovery Today: Therapeutic Strategies, 3 325-332 (2006) [C1]
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Co-authorsMing Yang, Philip Hansbro, Joerg Mattes
2006Kumar RK, Webb DC, Herbert C, Foster PS, 'Interferon - as a possible target in chronic asthma', Inflammation and Allergy - Drug Targets, 5 253-256 (2006) [C1]
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2006Siegle JS, Hansbro NG, Herbert C, Yang M, Foster PS, Kumar RK, 'Airway hyperreactivity in exacerbation of chronic asthma is independent of elosinophilic inflammation', American Journal of Respiratory Cell and Molecular Biology, 35 565-570 (2006) [C1]
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Co-authorsNicole Hansbro, Ming Yang
2006Swartz JM, Dyer KD, Cheever AW, Ramalingam T, Pesnicak L, Domachowske JB, et al., 'Schistosoma mansoni infection in eosinophil lineage-ablated mice', Blood, 108 2420-2427 (2006) [C1]
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CitationsScopus - 75Web of Science - 65
2005Prescott VE, Campbell PM, Moore A, Mattes J, Rothenberg ME, Foster PS, et al., 'Transgenic expression of bean alpha-amylase inhibitor in peas results in altered structure and immunogenicity', Journal of Agricultural and Food Chemistry, 53 9023-9030 (2005) [C1]
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CitationsScopus - 104Web of Science - 85
Co-authorsJoerg Mattes
2005Rolph MS, So T, Young T, Laybutt R, Commandeur ZA, Foster PS, et al., 'Control of obesity and glucose homeostasis by Th1/Th2 cytokines', INFLAMMATION RESEARCH, 54 S105-S106 (2005)
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2004Forbes E, Smart V, D'Aprile A, Henry P, Yang M, Matthaei KI, et al., 'T Helper-2 Immunity Regulates Bronchial Hyperresponsiveness in Eosinophil-Associated Gastrointestinal Disease in Mice', Gastroenterology, 127 105-118 (2004) [C1]
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Co-authorsMing Yang
2004Forbes E, Murase T, Yang M, Matthaei KI, Lee JJ, Lee NA, et al., 'Immunopathogenesis of experimental ulcerative colitis is mediated by eosinophil peroxidase1', J Immunol, 172 5664-5675 (2004) [C1]
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Co-authorsMing Yang
2004Webb DC, Matthaei KI, Cai Y, McKenzie ANJ, Foster PS, 'Polymorphisms in IL-4Ra correlate with airways hyperreactivity, eosinophilia, and Ym protein expression in allergic IL-13 -/- mice1', J Immunol, 172 1092-1098 (2004) [C1]
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2004Fulkerson PC, Zimmermann N, Brandt EB, Muntel EE, Doepker MP, Kavanaugh JL, et al., 'Negative regulation of eosinophil recruitment to the lung by the chemokine monokine induced by INF-g (Mig, CXCL9)', Proceedings of the National Academy of Sciences of the USA, 101 1987-1992 (2004) [C1]
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Co-authorsMing Yang
2004Clark K, Simson L, Newcombe N, Koskinen AML, Mattes J, Lee NA, et al., 'Eosinophil degranulation in the allergic lung of mice primarily occurs in the airway lumen', Journal of Leukocyte Biology, 75 1001-1009 (2004) [C1]
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Co-authorsJoerg Mattes
2004Kumar RK, Herbert C, Foster PS, 'Expression of growth factors by airway epithelial cells in a model of chronic asthma: regulation and relationship to subepithelial fibrosis', Clinical and Experimental Allergy, 34 567-575 (2004) [C1]
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2004Leigh R, Ellis R, Wattie JN, Hirota JA, Matthaei KI, Foster PS, et al., 'Type 2 cytokines in the pathogenesis of sustained airway dysfunction and airway remodelling in mice', Am J Resp Crit Care Med, 169 860-867 (2004) [C1]
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2004Kumar RK, Herbert C, Webb DC, Li L, Foster PS, 'Effects of anticytokine therapy in a mouse model of chronic asthma', Am, J Resp Crit Care Med, 170 1043-1048 (2004) [C1]
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2004Hogan SP, Rothenberg ME, Forbes E, Smart VE, Matthaei KI, Foster PS, 'Chemokines in Eosinophil-associated Gastrointestinal Disorders', Current Allergy and Asthma Reports, 4 74-82 (2004) [C1]
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2003Mattes J, Foster P, 'Regulation of eosinophil migration and Th2 cell function by IL-5 and eotaxin', Current Drug Targets, 2 169-174 (2003) [C1]
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Co-authorsJoerg Mattes
2003Foster PS, Yang M, Mattes J, Kumar R, Webb D, 'Interleukin-13 and allergy', Modern Aspects of Immunobiology, 3 8-8 (2003)
2003Matthaei KI, Donaldson DD, Foster PS, Webb DC, Mahalingam S, Cai Y, 'Antigen-specific production of interleukin (IL)-13 and IL-5 cooperate to mediate IL-4R&agr;-independent airway hyperreactivity', European Journal of Immunology, 33 3377-3385 (2003) [C1]
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Co-authorsMing Yang
2003Mattes J, Hulett M, Xie W, Hogan S, Rothenburg ME, Foster P, Parish C, 'Immunotherapy of cytotoxic T cell resistant tumors by T helper 2 cells: an eotaxin and STAT6 dependent process', Journal of Experimental Medicine, 197 387-393 (2003) [C1]
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Co-authorsJoerg Mattes
2003Smart V, Foster PS, Rothenberg ME, Higgins TJ, Hogan SP, 'A plant-based allergy vaccine suppresses experimental asthma via an IFN-y and CD4+ CD45RB low T cell-dependent mechanism', Journal of Immunology, 171 2116-2126 (2003) [C1]
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2003Kumar RK, Herbert C, Thomas PS, Wollin L, Beume R, Yang M, et al., 'Inhibition of inflammation and remodeling by roflumilast and dexamethasone in murine chronic asthma', Journal of Pharmacology and Experimental Therapeutics, 307 349-355 (2003) [C1]
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Co-authorsMing Yang
2003Yang M, Hogan SP, Mahalingam S, Pope SM, Zimmermann N, Fulkerson P, et al., 'Eotaxin-2 and 165 cooperate in the lung to regulate IL-13 production and airway eosinophilia and hyperreactivity', JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 112 935-943 (2003)
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2003Zimmermann N, Gurjit Khurana H, Foster PS, Rothenberg ME, 'Chemokines in asthma: Cooperative interaction between chemokines and IL-13', Journal of Allergy and Clinical Immunology, 111 227-242 (2003) [C1]
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Co-authorsMing Yang
2003Kruse S, Kuehr J, Moseler M, Kropp MV, Kurz T, Deichmann KA, et al., 'Polymorphisms in the IL18 gene are associated with specific sensitization to common allergens and allergic rhinitis', Journal of Allergy and Clinical Immunology, 111 117-122 (2003) [C1]
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Co-authorsJoerg Mattes
2003Foster PS, Webb DC, Yang M, Herbert C, Kumar RK, 'Dissociation of T helper type 2 cytokine-dependent airway lesions from signal transducer and activator of transcription 6 signalling in experimental chronic asthma', Clinical and Experimental Allergy, 33 688-695 (2003) [C1]
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Co-authorsMing Yang
2002Foster PS, Wong G, Yasuda S, Qi J, Mahalingam S, Mellor E, et al., 'Biochemical and functional characterization of human transmembrane tryptase (TMT)/tryptase gamma. TMT is an exocytosed mast cell protease that induces airway hyperresponsiveness in vivo via an interleukin-13/interleukin-4 receptor alpha/signal transducer and activator of transcription (STAT) 6-dependent pathway', Journal of Biological Chemistry, 277 1906-1915 (2002) [C1]
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2002Mishra A, Hogan S, Brandt E, Wagner N, Crossman M, Foster PS, Rothenberg M, 'Enterocyte expression of the eotaxin and interleukin-5 transgenes induces compartmentalized dysregulation of eosinophil trafficking', Journal of Biological Chemistry, 277 4406-4412 (2002) [C1]
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Co-authorsJoerg Mattes
2002Kumar R, Thomas P, Seetoo D-Q, Herbert C, McKenzie A, Foster PS, Lloyd A, 'Eotaxin expression by epithelial cells and plasma cells in chronic asthma', Laboratory Investigation, 82 495-504 (2002) [C1]
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2002Foster PS, Yang M, Herbert C, Kumar R, 'CD4+ T-lymphocytes regulate airway remodeling and hyper-reactivity in a mouse model of chronic asthma', Laboratory Investigation, 82 455-462 (2002) [C1]
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Co-authorsJoerg Mattes
2002Foster PS, Martinez-Moczygemba M, Huston D, Corry D, 'Interleukins-4, -5, and -13: emerging therapeutic targets in allergic disease', Pharmacology and Therapeutics, 94 253-264 (2002) [C1]
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2002Foster PS, Mahalingam S, Meanger J, Lidbury B, 'The viral manipulation of the host cellular and immune environments to enhance propagation and survival: a focus on RNA viruses', Journal of Leukocyte Biology, 72 429-439 (2002) [C2]
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2002Kumar R, Foster PS, 'ST2: marker, activator and regulator of Th2 immunity?', Clinical and Experimental Allergy, 32 1394-1396 (2002) [C2]
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2002Truong-Tran A, Ruffin R, Foster PS, Koskinen A, Coyle P, Philcox J, et al., 'Altered zinc homeostasis and caspase-3 activity in murine allergic airway inflammation', American Journal of Respiratory Cell and Molecular Biology, 27 286-296 (2002) [C1]
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2001Foster PS, Mahalingam S, Chaudhri G, Tan C, John A, Karupiah G, 'Transcription of the interferon (IFN-gamma)-inducible chemokine Mig in IFN-gamma-deficient Mice', Journal of Biological Chemistry, 276 7568-7574 (2001) [C1]
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2001Hertz M, Mahalingam S, Dalum I, Klysner S, Mattes J, Neisig A, et al., 'Active vaccination against IL-5 bypasses immunological tolerance and ameliorates experimental asthma', Journal of Immunology, 167 3792-3799 (2001) [C1]
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Co-authorsJoerg Mattes
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Co-authorsJoerg Mattes
2001Mattes J, Yang M, Siqueira A, Clark K, Mackenzie J, McKenzie A, et al., 'IL-13 induces airways hyperreactivity independently of the IL-4R{alpha} chain in the allergic lung', Journal of Immunology, 167 1683-1692 (2001) [C1]
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Co-authorsJoerg Mattes
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2000Webb D, McKenzie A, Koskinen A, Yang M, Mattes J, Foster PS, 'Integrated signals between IL-13, IL-4, and IL-5 regulate airways hyperreactivity', Journal of Immunology, 165 108-113 (2000) [C1]
CitationsScopus - 213Web of Science - 194
Co-authorsJoerg Mattes
2000Mould A, Ramsay A, Matthaei K, Young I, Rothenberg M, Foster PS, 'The effect of IL-5 and eotaxin expression in the lung on eosinophil trafficking and degranulation and the induction of bronchial hyperreactivity', Journal of Immunology, 164 2142-2150 (2000) [C1]
CitationsScopus - 125Web of Science - 119
2000Foster PS, Ming Y, Matthei K, Young I, Temelkovski J, Kumar R, 'Dissociation of inflammatory and epithelial responses in a murine model of chronic asthma', Laboratory Investigation, 80 655-662 (2000) [C1]
CitationsScopus - 71Web of Science - 66
2000Mahalingam S, Foster PS, Lobigs M, Farber J, Karupiah G, 'Interferon-inducible chemokines and immunity to poxvirus infections', Immunological Reviews, 177 127-133 (2000) [C3]
CitationsScopus - 16Web of Science - 17
1999Mishra A, Hogan S, Lee J, Foster PS, Rothenberg M, 'Fundamental signals that regulate eosinophil homing to the gastrointestinal tract', Journal of Clinical Investigation, 103 1719-1727 (1999) [C1]
CitationsScopus - 207Web of Science - 192
1999Xiong Y, Karupiah G, Hogan S, Foster PS, Ramsay A, 'Inhibition of allergic airway inflammation in mice lacking nitric oxide synthase 2', Journal of Immunology, 162 445-452 (1999) [C1]
CitationsScopus - 116Web of Science - 105
1999Rothenberg M, Zimmermann N, Mishra A, Brandt E, Birkenberger L, Hogan S, Foster PS, 'Chemokines and chemokine receptors: their role in allergic airway disease', Journal of Clinical Immunology, 19 250-265 (1999) [C2]
CitationsScopus - 71Web of Science - 66
1999Foster PS, 'STAT6: an intracellular target for the inhibition of allergic disease', Clinical and Experimental Allergy, 29 12-16 (1999) [C3]
CitationsScopus - 30Web of Science - 26
1999Foster PS, 'Allergic networks regulating eosinophilia', American Journal of Respiratory Cell and Molecular Biology, 21 451-454 (1999) [C2]
CitationsScopus - 22Web of Science - 18
1999Foster PS, Hogan S, 'The use of murine models to investigate the immune metworks underlying asthma', Current Opinion in Anti-inflammatory and Immunomod, 1 433-441 (1999) [C1]
1998Hogan S, Foster PS, Tan X, Ramsay A, 'Mucosal IL-12 gene delivery inhibits allergic airways disease and restores local antiviral immunity', European Journal of Immunology, 28 413-423 (1998) [C1]
CitationsScopus - 107Web of Science - 96
1998Hogan S, Matthaei K, Young J, Koskinen A, Young I, Foster PS, 'A novel T cell-regulated mechanism modulating allergen-induced airways hyperreactivity in BALB/c mice independently of IL-4 and IL-5', Journal of Immunology, 161 1501-1509 (1998) [C1]
CitationsScopus - 240Web of Science - 223
1998Temelkovski J, Hogan S, Shepherd D, Foster PS, Kumar R, 'An improved murine model of asthma: selective airway inflammation, epithelial lesions and increased methacholine responsiveness following chronic exposure to aerosolised allergen', Thorax, 53 849-856 (1998) [C1]
CitationsScopus - 247Web of Science - 209
1998Hogan S, Koskinen A, Matthaei K, Young I, Foster PS, 'Interleukin-5-producing CD4+ T cells play a pivotal role in aeroallergen-induced eosinophilia, bronchial hyperreactivity, and lung damage in mice', American Journal of Respiratory and Critical Care Medicine, 157 210-218 (1998) [C1]
CitationsScopus - 154Web of Science - 145
1997Hogan S, Mould A, Kikutani H, Ramasy A, Foster PS, 'Aeroallergen-induced eosinophilic inflammation, lung damage, and airways hyperreactivity in mice can occur independently of IL-4 and allergen-specific immunoglobulins', Journal of Clinical Investigation, 99 1329-1339 (1997) [C1]
CitationsScopus - 214Web of Science - 203
1997Mould A, Matthaei K, Young I, Foster PS, 'Relationship between interleukin-5 and eotaxin in regulating blood and tissue eosinophilia in mice', Journal of Clinical Investigation, 99 1064-1071 (1997) [C1]
CitationsScopus - 259Web of Science - 245
1997Kourie J, Foster PS, Dulhunty A, 'Inositol polyphosphates modify the kinetics of a small chloride channel in skeletal muscle sarcoplasmic reticulum', Journal of Membrane Biology: an international journal for studies on the structure function and genesis of biomembranes, 157 147-158 (1997) [C1]
CitationsScopus - 15Web of Science - 15
1997Hogan S, Foster PS, 'Cytokines as targets for the inhibition of eosinophilic inflammation', Pharmacology and Therapeutics, 74 259-283 (1997) [C2]
CitationsWeb of Science - 26
1997Matthaei K, Foster PS, Young I, 'The role of interleukin-5 (IL-5) in vivo: Studies with IL-5 deficient mice', Memorias do Instituto Oswaldo Cruz Rio de Janeiro, 92 63-68 (1997) [C1]
CitationsScopus - 24Web of Science - 24
1997Foster PS, Hogan S, Matthaei K, Young I, 'Interleukin-4 and interleukin-5 as targets for the inhibition of eosinophilic inflammation and allergic airways hyperreactivity', Memorias do Instituto Oswaldo Cruz Rio de Janeiro, 92 55-61 (1997) [C1]
CitationsScopus - 10Web of Science - 10
1997Hogan S, Koskinen A, Foster PS, 'Interleukin-5 and eosinophils induce airway damage and bronchial hyperreactivity during allergic airway inflammation in BALB/c mice', Immunology and Cell Biology, 75 284-288 (1997) [C1]
CitationsScopus - 89Web of Science - 79
1996Foster PS, Hogan S, Ramsay A, Matthaei K, Young I, 'Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model', Journal of Experimental Medicine, 183 195-201 (1996) [C1]
CitationsScopus - 1076Web of Science - 1014
1996Hogan S, Foster PS, 'Cellular and molecular mechanisms involved in the regulation of eosinophil trafficking in vivo', Medicinal Research Reviews, 16 407-432 (1996) [C1]
CitationsScopus - 20Web of Science - 21
1996Denborough M, Hopkinson K, O'Brien R, Foster PS, 'Overheating alone can trigger malignant hyperthermia in piglets', Anaesthesia and Intensive Care, 24 348-354 (1996) [C1]
CitationsScopus - 13Web of Science - 10
1995Taske N, Eyre H, O'Brien R, Sutherland G, Denborough M, Foster PS, 'Molecular cloning of the cDNA encoding human skeletal muscle triadin and its localisation to chromosome 6q22-6q23', The Federation of European Biochemical Societies (FEBS) Journal, 233 258-265 (1995) [C1]
CitationsScopus - 11Web of Science - 11
1995O'Brien R, Taske N, Hansbro P, Matthaei K, Hogan S, Denborough M, Foster PS, 'Exclusion of defects in the skeletal muscle specific regions of the DHPR alpha 1 subunit as frequent causes of malignant hyperthermia', Journal of Medical Genetics, 32 913-914 (1995) [C1]
CitationsScopus - 5Web of Science - 7
Co-authorsPhilip Hansbro
1994Hansbro P, Foster PS, Hogan S, Ozaki S, Denborough M, 'Purification and characterization of D-myo-Inositol (1,4,5)/(1,3,4,5)-polyphosphate 5-phosphatase from skeletal muscle', Archives of Biochemistry and Biophysics, 311 47-54 (1994) [C1]
CitationsScopus - 3Web of Science - 5
Co-authorsPhilip Hansbro
1994Foster PS, Hansbro P, Liu C, Potter B, Denborough M, 'Kinetic analysis of novel inhibitors of inositol polyphosphate metabolism', Biochemical and Biophysical Research Communications, 200 8-15 (1994) [C1]
CitationsScopus - 2Web of Science - 2
Co-authorsPhilip Hansbro
1994Foster PS, Hogan S, Hansbro P, O'Brien R, Potter B, Ozaki S, Denborough M, 'The metabolism of D-myo-inositol 1,4,5-trisphosphate and D-myo-inositol 1,3,4,5-tetrakisphosphate by porcine skeletal muscle', European Journal of Biochemistry, 222 955-964 (1994) [C1]
CitationsScopus - 12Web of Science - 12
Co-authorsPhilip Hansbro
1994Foster PS, 'The role of phosphoinositide metabolism in Ca2+ signalling of skeletal muscle cells', The International Journal of Biochemistry and Cell Biology, 26 449-468 (1994) [C1]
CitationsScopus - 10Web of Science - 12
1994Hogan S, Foster PS, Hansbro P, Ozaki S, Denborough M, 'Detection and partial purification of inositol 1,4,5-trisphosphate 3-kinase from porcine skeletal muscle', Cellular Signalling, 6 233-243 (1994) [C1]
CitationsScopus - 5Web of Science - 4
Co-authorsPhilip Hansbro
1993Foster PS, Denbobourgh M, 'The effect of calcium channel antagonists and BAY K 8644 on calcium fluxes of malignant hyperpyrexia-susceptible muscle', The International Journal of Biochemistry and Cell Biology, 25 495-504 (1993) [C1]
CitationsScopus - 1Web of Science - 2
1993Foster PS, Gesini E, Denborough M, 'Inositol 1,4,5-trisphosphate metabolism in red blood cells from individuals susceptible to malignant hyperpyrexia', Lancet, 342 986-987 (1993) [C3]
CitationsScopus - 9Web of Science - 8
1992Foster PS, Hopkinson K, Denborough M, 'Propofol anaesthesia in malignant hyperpyrexia susceptible swine', Clinical and Experimental Pharmacology and Physiology, 19 183-186 (1992) [C1]
CitationsScopus - 4Web of Science - 4
1991Foster PS, Hopkinson K, Payne N, Denborough M, 'The effect of azumolene on hypercontractility and sarcoplasmic reticulum Ca(2+)-dependent ATPase activity of malignant hyperpyrexia-susceptible porcine skeletal muscle', Clinical and Experimental Pharmacology and Physiology, 18 489-495 (1991) [C1]
CitationsScopus - 8Web of Science - 9
1990FOSTER PS, 'MALIGNANT HYPERPYREXIA', INTERNATIONAL JOURNAL OF BIOCHEMISTRY, 22 1217-1222 (1990)
DOI10.1016/0020-711X(90)90301-IAuthor URL
CitationsScopus - 6Web of Science - 10
1990Foster PS, 'Malignant hyperpyrexia (Short Survey)', The International Journal of Biochemistry and Cell Biology, 22 1217-1222 (1990) [C1]
1989Foster PS, Denborough M, 'Effect of diltiazem and dantrolene on the contractility of isolated malignant hyperpyrexia-susceptible porcine skeletal muscle', British Journal of Anaesthesia, 62 566-572 (1989) [C1]
CitationsScopus - 5Web of Science - 13
1989Foster PS, Hopkinson K, Denborough M, 'Effect of diltiazem on porcine malignant hyperpyrexia induced by suxamethonium and halothane', British Journal of Anaesthesia, 62 560-565 (1989) [C1]
CitationsScopus - 1Web of Science - 3
1989Foster PS, White M, Denborough M, 'Characterization of the terminal cisternae and longitudinal tubules of sarcoplasmic reticulum from malignant hyperpyrexia susceptible porcine skeletal muscle', International Journal of Biochemistry, 21 1119-1126 (1989) [C1]
CitationsScopus - 6Web of Science - 7
1989Foster PS, Claudianos C, Gesini E, Hopkinson K, Denborough M, 'Inositol 1,4,5,-trisphosphate phosphatase deficiency and malignant hyperpyrexia in swine', Lancet, 2 124-127 (1989) [C1]
CitationsScopus - 39Web of Science - 62
1989Foster PS, Hopkinson K, Denborough MA, '31P-NMR spectroscopy: The metabolic profile of malignant hyperpyrexic porcine skeletal muscle', Muscle and Nerve, 12 390-396 (1989)

31Phosphorus-NMR spectroscopy may have the potential to help in the noninvasive diagnosis of malignant hyperpyrexia (MH). Changes in the phosphate-metabolite profile of MH-susceptible (MHS) skeletal muscle occur more readily under conditions of anoxia than in control muscle. Induction of anoxia causes a rapid fall in intracellular phosphocreatine, an elevation of inorganic phosphate, and finally a diminution of ATP in MHS muscle. The onset of metabolic change was slower in control tissue. Increased oxygen consumption may occur in anoxic MHS muscle, which leads to accelerated glycolysis and a rapid fall in the intracellular high-energy phosphates. In MHS muscle an abnormality may exist in carbohydrate metabolism linked with poor resynthesis of the high-energy phosphates, which may be precipitated under anaerobic conditions. Accelerated muscle metabolism is also observed in the presence of 2 mM caffeine and 3% halothane in MHS muscle. Changes in the concentrations of metabolites could be mapped noninvasively under anoxic conditions using topical 31P-NMR.

CitationsScopus - 5
1989Foster PS, Hopkinson K, Denborough M, '31P-NMR spectroscopy: The metabolic profile of malignant hyperpyrexic porcine skeletal muscle', Muscle and Nerve, 12 390-396 (1989) [C1]
CitationsWeb of Science - 8
1989Foster PS, Hopkinson K, Denborough M, 'Effect of diltiazem, verapamil and dantrolene on the contractility of isolated malignant hyperpyrexia-susceptible human skeletal muscle', Clinical and Experimental Pharmacology and Physiology, 16 799-805 (1989) [C1]
CitationsScopus - 2Web of Science - 4
1983Foster PS, Goldie R, Paterson J, Spina D, 'Effect of hypothermia on beta 1-adrenoceptor-mediated relaxation of pig bronchus', British Journal of Pharmacology, 80 699-702 (1983) [C1]
CitationsWeb of Science - 2
1983Foster PS, Goldie R, Paterson J, 'Effect of steroids on beta-adrenoreceptor-mediated relaxation of pig bronchus', British Journal of Pharmacology, 78 441-445 (1983) [C1]
CitationsWeb of Science - 89
Show 211 more journal articles

Review (2 outputs)

YearCitationAltmetricsLink
2013Plank M, Maltby S, Mattes J, Foster PS, 'Targeting translational control as a novel way to treat inflammatory disease: The emerging role of MicroRNAs', Clinical and Experimental Allergy (2013) [C1]

Chronic inflammatory diseases (e.g. asthma and chronic obstructive pulmonary disease) are leading causes of morbidity and mortality world-wide and effective treatments are limited. These disorders can often be attributed to abnormal immune responses to environmental stimuli and infections. Mechanisms leading to inflammation are complex, resulting from interactions of structural cells and activation of both the adaptive and innate arms of the immune system. The activation of structural and immune cells involves both temporary and permanent changes in gene expression in these cells, which underpin chronic inflammation and tissue dysfunction. miRNAs are small non-coding RNAs increasingly being recognized to play important roles in the post-transcriptional regulation of gene expression in mammalian cells by regulating translation. Individual miRNAs can exert their effects by directly inhibiting the translation or stability of multiple mRNAs simultaneously. Thus, the expression or blockade of function of a single miRNA (miR) can result in pronounced alterations in protein expression within a given cell. Dysregulation of miRNA expression may subsequently alter cellular function, and in certain situations predispose to disease. Our current understanding of the role of miRNA in the regulation of inflammatory disease (e.g. allergic diseases) remains limited. In this review, we provide an overview of the current understanding of miRNA biogenesis and function, the roles miRNA play in the regulation of immune cell function and their potential contribution to inflammatory diseases. We also highlight strategies to alter miRNA function for experimental or therapeutic gain, and discuss the potential utility and limitations of targeting these molecules as anti-inflammatory strategies. © 2013 John Wiley & Sons Ltd.

DOI10.1111/cea.12135
CitationsScopus - 6Web of Science - 5
Co-authorsJoerg Mattes, Steven Maltby
2013Plank M, Maltby S, Mattes J, Foster PS, 'Targeting translational control as a novel way to treat inflammatory disease: the emerging role of microRNAs.', Clinical and Experimental Allergy (2013) [C1]
DOI10.1111/cea.12170Author URL
Co-authorsJoerg Mattes, Steven Maltby

Conference (107 outputs)

YearCitationAltmetricsLink
2014Starkey M, Hanish I, Dua K, Nair P, Haw T, Hsu A, et al., 'Interleukin-13 predisposes mice to more severe influenza infection by suppressing interferon responses and activating microRNA-21/PI3K', CYTOKINE, Melbourne, AUSTRALIA (2014) [E3]
DOI10.1016/j.cyto2014.07.182Author URL
Co-authorsPeter Wark, Philip Hansbro, Darryl Knight, Alan Hsu, Malcolm Starkey, Jay Horvat
2014Collison A, Hatchwell L, Girkin J, Li J, Parsons K, Bartlett N, et al., 'REDUCED TLR7 EXPRESSION MAY UNDERPIN IMPAIRED RESPONSE TO VIRAL INFECTION IN ASTHMA', RESPIROLOGY (2014) [E3]
DOI10.1111/resp.12263_5Author URL
Co-authorsJoerg Mattes, Peter Wark
2013Tay H, Kaiko G, Hansbro P, Foster P, 'The role of miRNA in regulating bacterial clearance', JOURNAL OF IMMUNOLOGY, Honolulu, HI (2013) [E3]
Author URL
Co-authorsPhilip Hansbro
2013Hansbro P, Beckett E, Stevens R, Jarnicki A, Kim R, Hanish I, et al., 'A short-term model of COPD identifies a role for mast cell tryptase', JOURNAL OF IMMUNOLOGY, Honolulu, HI (2013) [E3]
Author URL
Co-authorsMing Yang, Philip Hansbro, Nicole Hansbro, Simon Keely, Peter Wark, Jay Horvat
2013Hansbro P, Horvat J, Essilfie A-T, Kim R, Mayall J, Starkey M, Foster P, 'Macrolides suppress key features of experimental steroid-sensitive and steroid-resistant asthma', JOURNAL OF IMMUNOLOGY, Honolulu, HI (2013) [E3]
Author URL
Co-authorsMalcolm Starkey, Philip Hansbro, Jay Horvat
2013Girkin J, Hatchwell L, Foster PS, Johnston SL, Collison A, Mattes J, 'SALMETEROL ATTENUATES CHEMOTAXIS IN RHINOVIRUS-INDUCED EXACERBATION OF ASTHMA VIA MODULATION OF PP2A', RESPIROLOGY (2013) [E3]
Author URL
Co-authorsJoerg Mattes
2013Kim RY, Horvat JC, Starkey MR, Essilfie A-T, Foster PS, Hansbro PM, 'MICRORNA INHIBITION IN NEONATAL CHLAMYDIA LUNG INFECTION PREVENTS INFECTION-INDUCED LUNG PATHOLOGY IN LATER LIFE', RESPIROLOGY (2013) [E3]
Author URL
Co-authorsMalcolm Starkey, Philip Hansbro, Jay Horvat
2013Herbert C, Siegle JS, Shadie AM, Nikolaysen S, Garthwaite L, Hansbro NG, et al., 'EARLY LIFE EXPOSURE TO ENVIRONMENTAL PARTICULATES PREDISPOSES TO DEVELOPMENT OF ASTHMATIC INFLAMMATION', RESPIROLOGY (2013) [E3]
Author URL
Co-authorsNicole Hansbro
2013Horvat JC, Essilfie A-T, Kim RY, Mayall JR, Starkey MR, Beckett EL, et al., 'MACROLIDES SUPPRESS KEY FEATURES OF EXPERIMENTAL STEROID-SENSITIVE AND STEROID-RESISTANT ASTHMA', RESPIROLOGY (2013) [E3]
Author URL
CitationsScopus - 1
Co-authorsPeter Gibson, Philip Hansbro, Malcolm Starkey, Jay Horvat
2013Hatchwell L, Collison A, Phipps S, Foster PS, Johnston SL, Mattes J, 'CCL7 (MCP-3) MEDIATES RHINOVIRUS-INDUCED LUNG INFLAMMATION AND EXACERBATION OF ALLERGIC AIRWAY DISEASE', RESPIROLOGY (2013) [E3]
Author URL
Co-authorsJoerg Mattes
2012Kaiko GE, Tay HL, Plank MW, Hansbro PM, Foster PS, 'MicroRNA regulate bacterial phagocytosis in the lung', Immunology: Abstracts of the European Congress of Immunology, Glasgow, Scotland (2012) [E3]
Co-authorsPhilip Hansbro
2012Starkey M, Kim R, Horvat J, Essilfie A-T, Beagley K, Mattes J, et al., 'Constitutive IL-13 promotes respiratory chlamydial infection and infection-induced chronic airway hyper-responsiveness', JOURNAL OF IMMUNOLOGY, Boston, MA (2012) [E3]
Author URL
Co-authorsPhilip Hansbro, Joerg Mattes
2012Collison AM, Hatchwell LM, Siqueira AP, Bartlett NW, Johnston SL, Foster PS, Mattes J, 'Antagonism of microRNA-122 is comparible to azithromycin treatment in a mouse model of rhinovirus-induced exacerbation of allergic airways disease', Respirology, Canberra, ACT (2012) [E3]
Co-authorsJoerg Mattes
2012Hatchwell LM, Collison AM, Siqueira AP, Bartlett NW, Johnston SL, Foster PS, Mattes J, 'Toll-like receptor 7 mediates anti-viral responses to rhinovirus while suppressing exacerbation of asthma', Respirology, Canberra, ACT (2012) [E3]
Co-authorsJoerg Mattes
2012Hatchwell LM, Collison AM, Siqueira AP, Bartlett NW, Johnston SL, Foster PS, Mattes J, 'TRAIL regulates inflammatory responses to rhinovirus and rhinovirus-induced exacerbation of asthma', Respirology, Canberra, ACT (2012) [E3]
Co-authorsJoerg Mattes
2012Horvat JC, Essilfie A-T, Kim RY, Mayall JR, Starkey MR, Beckett EL, et al., 'Efficacy of antibiotic-based therapeutic strategies for the treatment of infection-induced, steroid-resistant allergic airways disease', Respirology, Canberra, ACT (2012) [E3]
Co-authorsPhilip Hansbro, Malcolm Starkey, Jay Horvat
2012Kaiko GE, Phipps S, Plank MW, Tay HL, Lam CE, Foster PS, 'Inhibition of microRNA reverses CD8 T cell exhaustion and improves immunity against respiratory virus infection', Respirology, Canberra, ACT (2012) [E3]
2012Li J, Foster PS, Yang M, 'Inducible microRNA-X expression underpins steroid- resistant airway hyperresponsiveness by upregulating IL-27 expression', Respirology, Canberra, ACT (2012) [E3]
Co-authorsMing Yang
2012Plank MW, Kaiko GE, Luck H, Li J, Mattes J, Hansbro PM, Foster PS, 'The role of micrornas in CD4 T cell function', Respirology, Canberra, ACT (2012) [E3]
Co-authorsPhilip Hansbro, Joerg Mattes
2012Starkey MR, Kim RY, Horvat JC, Essilfie A-T, Beagley KW, Mattes J, et al., 'Constitutive IL-13 promotes respiratory chlamydial infection-induced chronic airway hyperresponsiveness', Respirology, Canberra, ACT (2012) [E3]
Co-authorsPhilip Hansbro, Joerg Mattes, Jay Horvat, Malcolm Starkey
2012Tay HL, Kaiko GE, Plank MW, Mattes J, Hansbro PM, Foster PS, 'MiRNAs regulate bacterial infection in lungs', Respirology, Canberra, ACT (2012) [E3]
Co-authorsJoerg Mattes, Philip Hansbro
2011Wu DXY, Ahrens R, Osterfeld H, Groschwitz K, Foster P, Rothenberg ME, et al., 'Interleukin-13 (IL-13)/IL-13 receptor alpha 1 (IL-13R alpha 1) signaling regulates intestinal epithelial Cystic fibrosis transmembrane conductance regulator (CFTR) channel-dependent Cl- secretion', FASEB JOURNAL, Washington, DC (2011) [E3]
Author URL
2011Foster PS, Tay HL, Kaiko GE, Plank MW, Mattes J, Hansbro PM, 'MiRNA and its roles in regulating bacterial infection in lungs', American Journal of Respiratory and Critical Care Medicine, Denver, CO (2011) [E3]
Co-authorsPhilip Hansbro, Joerg Mattes
2011Hansbro PM, Horvat JC, Essilfie A-T, Kim RY, Simpson JL, Dunkley ML, et al., 'Infection-induced neutrophilic allergic airways disease is resistant to steroid treatment', American Journal of Respiratory and Critical Care Medicine, Denver, CO (2011) [E3]
Co-authorsJay Horvat, Peter Gibson, Philip Hansbro, Margaret Dunkley, Jodie Simpson
2011Horvat JC, Essilfie A-T, Kim RY, Simpson JL, Dunkley ML, Beagley KW, et al., 'Investigation of infection-induced steroid resistant asthma', Respirology, Perth, WA (2011) [E3]
Co-authorsJay Horvat, Peter Gibson, Margaret Dunkley, Philip Hansbro, Jodie Simpson
2011Collison AM, Hatchwell LM, Pereira De Siqueira AL, Don A, Verrills NM, Foster PS, Mattes J, 'The development of house dust mite-induced allergic airways disease is regulated by a novel E3 ubiquitin ligase-dependent deactivation of a protein phosphatase', Respirology, Perth, WA (2011) [E3]
Co-authorsJoerg Mattes, Nikki Verrills
2011Hatchwell LM, Collison AM, Pereira De Siqueira AL, Foster PS, Verrills NM, Don A, et al., 'A novel E3 ubiquitin ligase links rhinovirus infection to exacerbation of asthma', Respirology, Perth, WA (2011) [E3]
Co-authorsNikki Verrills, Joerg Mattes, Peter Wark
2011Mattes J, Hankin RG, Hilton JM, Collison AM, Pereira De Siqueira AL, Gulliver T, et al., 'Frequent persistent wheeze in infancy may be associated with impaired FEV0.5 and FVC values', Respirology, Perth, WA (2011) [E3]
Co-authorsJoerg Mattes
2010Hansbro PM, Essilfie A-T, Simpson JL, Dunkley ML, Horvat JC, Gibson PG, Foster PS, 'Haemophilus influenzae induces IL-17-mediated neutrophilic allergic airways disease', American Journal of Respiratory and Critical Care Medicine, New Orleans (2010) [E3]
CitationsScopus - 37Web of Science - 34
Co-authorsJodie Simpson, Philip Hansbro, Jay Horvat, Peter Gibson, Margaret Dunkley
2010Herbert C, Scott MM, Keogh R, Siegle JS, Yuan K, Tedla N, et al., 'Alternatively activated alveolar macrophages stimulate Th2 cytokine production by primed CD4+ T cells in a model of an acute exacerbation of asthma', American Journal of Respiratory and Critical Care Medicine, New Orleans (2010) [E3]
2010Ptaschinski CM, Phipps S, Hansbro NG, Rosenberg HF, Mattes J, Foster PS, 'MicroRNAs are involved in the regulation of inflammatory responses characteristic of severe respiratory virus infection', American Journal of Respiratory and Critical Care Medicine, New Orleans (2010) [E3]
Co-authorsNicole Hansbro, Joerg Mattes
2010Thorburn AN, Foster PS, Gibson PG, Hansbro PM, 'Development of a streptococcus pneumoniae-based immunoregulatory therapy for asthma', American Journal of Respiratory and Critical Care Medicine, New Orleans (2010) [E3]
Co-authorsPeter Gibson, Philip Hansbro
2010Thorburn AN, Foster PS, Gibson PG, Hansbro PM, 'Streptococcus pneumoniae vaccine, prevenar, induces regulatory T cells and prevents allergic airways disease', American Journal of Respiratory and Critical Care Medicine, New Orleans (2010) [E3]
Co-authorsPhilip Hansbro, Peter Gibson
2010Mattes J, Collison AM, Plank MW, Phipps S, Foster PS, 'The role of microRNA as new anti-inflammatory targets', APCAACI 2010: The 8th Asia Pacific Congress on Allergy, Asthma and Clinical Immunology Programme & Abstracts Handbook, Singapore (2010) [E3]
Co-authorsJoerg Mattes
2010Siegle J, Hansbro NG, Dong C, Angkasekwinai P, Foster PS, Kumar R, 'Anti-Th2 cytokines inhibit progression in a murine model of childhood asthma', European Respiratory Society Annual Congress 2010. Abstracts, Barcelona, Spain (2010) [E3]
Co-authorsNicole Hansbro
2010Ptaschinski CM, Adachi R, Rosenberg HF, Stevens RL, Foster PS, 'Beneficial role for the tryptase mouse mast cell protease 6 in the innate immune response in the lung to pneumonia virus of mice', Translational Science: From Basic to Clinincal Immunology and Allergy, Ischia, Italy (2010) [E3]
2010Foster PS, Mattes J, Collison AM, Plank MW, Phipps S, 'MicoRNAs bridge innate and adative immunity: induction of TH2 mediated allergic airways disease', OzBio 2010: The Molecules of Life - from Discovery to Biotechnology. Abstracts, Melbourne, Vic (2010) [E3]
Co-authorsJoerg Mattes
2010Foo A, Lam CE, Foster PS, Phipps S, 'Regulatory T cells suppress the formation of inducible bronchus-associated lymphoid tissue in weanling mice', Respirology, Brisbane, QLD (2010) [E3]
2010Lam CE, Foo A, Essilfie A-T, Hansbro PM, Matthaei KI, Foster PS, Phipps S, 'Chemerin derived peptide reduces LPS and haemophilus influenza-induced emphysema in mice', Respirology, Brisbane, QLD (2010) [E3]
Co-authorsPhilip Hansbro
2009Foo A, Lam CE, Foster PS, Phipps S, 'Regulatory T cells suppress the development of inducible bronchus-associated lymphoid tissue (iBALT) in weanling mice', 39th Annual Meeting of the Australasian Society for Immunology: Program, Broadbeach, QLD (2009) [E3]
2009Hansbro PM, Starkey MR, Horvat JC, Kim RY, Phipps S, Gibson PG, Foster PS, 'Early life chlamydial infection enhances allergic airways disease through age-dependent differences in immunopathology', Journal of Immunology, Seattle, WASH. (2009) [E3]
DOI10.1016/j.jaci.2009.10.018
Co-authorsJay Horvat, Peter Gibson, Philip Hansbro, Malcolm Starkey
2009Hansbro PM, Thorburn AN, Foster PS, Gibson PG, 'Streptococcus pneumoniae vaccine, Prevenar, utilises Tregs to suppress asthma', Journal of Immunology, Seattle, WASH. (2009) [E3]
Co-authorsPhilip Hansbro, Peter Gibson
2009Horvat JC, Starkey MR, Beagley KW, Gibson PG, Foster PS, Hansbro PM, 'Chlamydial respiratory infection predisposes to neutrophil dominated allergic airways disease (AAD)', Journal of Immunology, Seattle, WASH. (2009) [E3]
Co-authorsPhilip Hansbro, Jay Horvat, Malcolm Starkey, Peter Gibson
2009Wu DX, Ahrens RE, Groschwitz KR, Osterfield HN, Foster PS, Finkelman FD, et al., 'Elevated intestinal interleukin-13 promotes intestinal epithelial barrier dysfunction', The Journal of Allergy and Clinical Immunology, Washington, DC (2009) [E3]
2009Collison AM, Mattes J, Phipps S, Plank MW, Foster PS, 'MicroRNAs are crucial in the development of airways hyperreactivity', American Journal of Respiratory and Critical Care Medicine, San Diego, CA (2009) [E3]
Co-authorsJoerg Mattes
2009Foo A, Lam CE, Wark PA, Foster PS, Phipps S, 'Immune mechanisms that promote the development of inducible bronchus-associated lymphoid tissue (iBALT)', American Journal of Respiratory and Critical Care Medicine, San Diego, CA (2009) [E3]
Co-authorsPeter Wark
2009Lam CE, Foo A, Matthaei KI, Foster PS, Phipps S, 'Repeated stimulation of toll-like receptor 4 is sufficient to induce emphysematous lesions in mice', American Journal of Respiratory and Critical Care Medicine, San Diego, CA (2009) [E3]
2009Mattes J, Collison AM, Plank MW, Phipps S, Foster PS, 'MicroRNAs regulate allergic airway inflammation', American Journal of Respiratory and Critical Care Medicine, San Diego, CA (2009) [E3]
Co-authorsJoerg Mattes
2009Herbert C, Scruton K, Hsu K, Siegle JS, Hansbro NG, Foster PS, et al., 'Enhanced expression of cytokines by pulmonary T-cells and macrophages in a model of exacerbations of chronic asthma', American Journal of Respiratory and Critical Care Medicine, San Diego, CA (2009) [E3]
Co-authorsNicole Hansbro
2009Collison AM, De Siqueira A, Plank MW, Foster PS, Mattes J, 'The identification of TRAIL as a mediator of airways remodelling in a chronic model of murine allergic airways disease', American Journal of Respiratory and Critical Care Medicine, San Diego, CA (2009) [E3]
Co-authorsJoerg Mattes
2009Thorburn AN, O'Sullivan B, Thomas R, Foster PS, Gibson PG, Hansbro PM, 'Prevenar suppresses allergic airways disease through the expansion of regulatory T cells', Respirology, Darwin, NT (2009) [E3]
DOI10.1111/j.1440-1843.2009.01503_1.x
Co-authorsPhilip Hansbro, Peter Gibson
2009Siegle JS, Hansbro NG, Herbert C, Rosenberg HF, Asquith KL, Foster PS, Kumar RK, 'Interaction between early-life viral infection and allergen exposure induces an asthmatic phenotype in mice', Respirology, Darwin, NT (2009) [E3]
DOI10.1111/j.1440-1843.2009.01502_7.x
Co-authorsNicole Hansbro
2009Essilfie A-T, Simpson JL, Dunkley ML, Foster PS, Gibson PG, Hansbro PM, 'Haemophilus influenzae infection induces features of neutrophilic asthma', Respirology, Darwin, NT (2009) [E3]
DOI10.1111/j.1440-1843.2009.01503_1.x
Co-authorsPeter Gibson, Jodie Simpson, Philip Hansbro, Margaret Dunkley
2009Horvat JC, Starkey MR, Beagley KW, Preston JA, Gibson PG, Foster PS, Hansbro PM, 'Neutrophil influx during chlamydial lung infection determines the phenotype of allergic airways disease (AAD)', Respirology, Darwin, NT (2009) [E3]
DOI10.1111/j.1440-1843.2009.01503_1.x
Co-authorsPhilip Hansbro, Peter Gibson, Jay Horvat, Malcolm Starkey
2009Starkey MR, Horvat JC, Kim RY, Phipps S, Gibson PG, Beagley KW, et al., 'Early life chlamydial lung infection enhances allergic airways disease through age-dependent differences in immunopathology', Respirology, Darwin, NT (2009) [E3]
DOI10.1016/j.jaci.2009.10.018
CitationsScopus - 46Web of Science - 46
Co-authorsPeter Gibson, Philip Hansbro, Jay Horvat, Malcolm Starkey
2009Weckmann M, Lau J, Grafton K, Oliver B, Hansbro NG, Foster PS, et al., 'Tumstatin: A non-collagenous domain of collagen IV: Effects on inflammation and angiogenesis', Respirology, Darwin, NT (2009) [E3]
Co-authorsNicole Hansbro, Philip Hansbro
2008Burgess JK, Boustany S, Oliver BG, Moir LM, Baraket M, Hansbro PM, et al., 'The absence of tumstatin in asthma may lead to angiogenesis and airway hyperresponsiveness', American Journal of Respiratory and Critical Care Medicine, Toronto, ONT (2008) [E3]
Co-authorsPhilip Hansbro, Nicole Hansbro
2008Hansbro PM, Essilfie A-T, Foster PS, Gibson PG, 'Haemophilus influenzae (Hi) infection in asthma may drive the development of neutrophilic asthma (NA)', American Journal of Respiratory and Critical Care Medicine, Toronto, ONT (2008) [E3]
Co-authorsPhilip Hansbro, Peter Gibson
2008Hansbro PM, Horvat JC, Beagley KW, Gibson PG, Foster PS, 'Neutrophil influx during chlamydial lung infection determines the phenotype of allergic airways disease', American Journal of Respiratory and Critical Care Medicine, Toronto, ONT (2008) [E3]
Co-authorsPhilip Hansbro, Peter Gibson, Jay Horvat
2008Hansbro PM, Thorburn AN, Foster PS, Gibson PG, 'Streptococcus Pneumoniae vaccine prevenar: A potential therapy for the suppression of asthma', American Journal of Respiratory and Critical Care Medicine, Toronto, ONT (2008) [E3]
Co-authorsPhilip Hansbro, Peter Gibson
2008Yang M, Ma C, Foster PS, 'Antigen-specific TH1 cells induce airway hyper-reactivity in co-operation with lipopolysaccharide in BALB/C mice', Respirology, Melbourne, VIC (2008) [E3]
DOI10.1111/j.1440-1843.2008.01252.x
Co-authorsMing Yang
2008Thorburn AN, Foster PS, Gibson PG, Hansbro PM, 'Streptococcus pneumoniae vaccine prevenar: A potential therapy for the suppression of asthma', Respirology, Melbourne, VIC (2008) [E3]
DOI10.1111/j.1440-1843.2008.01252.x
Co-authorsPeter Gibson, Philip Hansbro
2008Horvat JC, Beagley KW, Gibson PG, Foster PS, Hansbro PM, 'Neutrophil influx during chlamydial lung infection determines the phenotype of allergic airways disease', Respirology, Melbourne, VIC (2008) [E3]
DOI10.1111/j.1440-1843.2008.01252.x
Co-authorsPhilip Hansbro, Peter Gibson, Jay Horvat
2008Essilfie A-T, Preston JA, Horvat JC, Dunkley ML, Foster PS, Gibson PG, et al., 'Haemophilus influenzae (Hi) infection in asthma may drive the development of neutrophilic asthma (NA)', Respirology, Melbourne, VIC (2008) [E3]
DOI10.1111/j.1440-1843.2008.01252.x
Co-authorsJay Horvat, Peter Gibson, Jodie Simpson, Margaret Dunkley, Philip Hansbro
2008Hansbro NG, Boustany S, Oliver B, Burgess J, Black J, Rosenberg H, et al., 'Early life pneumoviral infection induces the development of pulmonary angiogenesis', Respirology, Melbourne, VIC (2008) [E3]
DOI10.1111/j.1440-1843.2008.01252.x
Co-authorsNicole Hansbro, Philip Hansbro
2008Boustany S, Oliver BG, Moir LM, Black JL, Hansbro PM, Hansbro NG, et al., 'Tumstatin, an angiogenic inhibitor, modulates airway angiogenesis', Respirology, Melbourne, VIC (2008) [E3]
DOI10.1111/j.1440-1843.2008.01252_4.x
Co-authorsNicole Hansbro, Philip Hansbro
2008Hansbro PM, Essilfie A-T, Simpson JL, Dunkley ML, Gibson PG, Foster PS, 'Haemophilus influenzae (HI) infection induces features of neutrophilic asthma', Australasian Society for Immunology 38th Annual Scientific Meeting: Delegate Book, Canberra, ACT (2008) [E3]
Co-authorsMargaret Dunkley, Philip Hansbro, Jodie Simpson, Peter Gibson
2008Hazelwood L, Wood LG, Hansbro PM, Foster PS, 'High fat diet reduces eosinophilic lung inflammation via nicotinic acetylcholine-dependent signaling', Australasian Society for Immunology 38th Annual Scientific Meeting: Delegate Book, Canberra, ACT (2008) [E3]
Co-authorsLisa Wood, Philip Hansbro
2008Starkey MR, Horvat JC, Kim RY, Phipps S, Gibson PG, Beagley KW, et al., 'Early life chlamydial lung infection enhances allergic airways disease through age-dependent differences in immunopathology', Australasian Society for Immunology 38th Annual Scientific Meeting: Delegate Book, Canberra, ACT (2008) [E3]
Co-authorsMalcolm Starkey, Jay Horvat, Philip Hansbro, Peter Gibson
2008Thorburn AN, O'Sullivan BJ, Thomas R, Foster PS, Gibson PG, Hansbro PM, 'Suppression of allergic airways disease by the Streptococcus pneumoniae vaccine prevenar through the induction of regulatory T cells', Australasian Society for Immunology 38th Annual Scientific Meeting: Delegate Book, Canberra, ACT (2008) [E3]
Co-authorsPhilip Hansbro, Peter Gibson
2008Asquith KL, Ramshaw H, Lopez A, Foster PS, 'The IL-3/IL-5/GM-CSF Common beta Receptor Plays a Pivotal Role in Regulating Th2 Immunity and Allergic Airway Inflammation', FASEB JOURNAL (2008) [E3]
Author URL
Co-authorsPhilip Hansbro
2007Phipps S, Lam CE, Kaiko GE, Collison A, Smith L, Mansell A, et al., 'Contribution of multiple toll-like receptors to the development of murine allergic airways inflammation', Immunology and Cell Biology, Manly, NSW (2007) [E3]
2007Kaiko GE, Phipps S, Foster PS, 'Importance of CD4 T cells in the clearance of a primary Respiratory Syncytial Virus infection and in protection against the development of exhausted CD8 T cell memory', Immunology and Cell Biology, Manly, NSW (2007) [E3]
2007Horvat JC, Preston JA, Gibson PG, Beagley KW, Foster PS, Hansbro PM, 'Development of allergic airways disease (AAD) is differentially affected by the timing of chlamydial infection relative to allergic sensitization', American Journal of Respiratory and Critical Care Medicine, San Francisco, Calif. (2007) [E3]
Co-authorsJay Horvat, Peter Gibson, Philip Hansbro
2007Horvat JC, Garside CG, Wade MA, Preston JA, Hansbro NG, Gibson PG, et al., 'Development of allergic airways disease is differentially affected by chlamydial respiratory infection at different ages', American Journal of Respiratory and Critical Care Medicine, San Francisco, Calif. (2007) [E3]
Co-authorsPhilip Hansbro, Nicole Hansbro, Peter Gibson, Jay Horvat
2007Kaiko GE, Phipps S, Foster PS, 'Respiratory Syncytial Virus up-regulates PD-1 expression; comparison to a model of CD8 T cell exhaustion in BALB/c mice', Immuno 2007: 13th International Congress of Immunology, Abstracts and Posters, Rio de Janeiro, Brazil (2007) [E3]
2007Hansbro NG, Boustany S, Oliver BG, Burgess JK, Black JL, Hansbro PM, Foster PS, 'Viral-induced angiogenesis', Immuno 2007: 13th International Congress of Immunology. Abstracts and Posters, Rio de Janeiro, Brazil (2007) [E3]
Co-authorsPhilip Hansbro, Nicole Hansbro
2007Essiflie A, Preston JA, Horvat JC, Dunkley ML, Foster PS, Gibson PG, et al., 'Elucidating the association between Haemophilus influenzae infection and neutrophilic allergic airways disease using mouse models', Immuno 2007: 13th International Congress of Immunology. Abstracts and Posters, Rio de Janeiro, Brazil (2007) [E3]
Co-authorsMargaret Dunkley, Jay Horvat, Peter Gibson, Jodie Simpson, Philip Hansbro
2007Ferguson AL, Beagley KW, Hansbro PM, Foster PS, 'CD4+ T-cell programming by adult and neonatal bacterial infections inhibit the development of allergic airway inflammation in later life', Immuno 2007: 13th International Congress on Immunology. Abstracts and Posters, Rio de Janeiro, Brazil (2007) [E3]
Co-authorsPhilip Hansbro
2007Horvat JC, Moller CG, Wade MA, Preston JA, Hansbro NG, Gibson PG, et al., 'Allergic airways disease (AAD) is differentially affected by chlamydial lung infection at different stages of life', Respirology (TSANZ Abstracts-Posters), Auckland (2007) [E3]
DOI10.1111/j.1440-1843.2007.001050.x
Co-authorsPhilip Hansbro, Nicole Hansbro, Peter Gibson, Jay Horvat
2007Horvat JC, Preston JA, Gibson PG, Beagley KW, Foster PS, Hansbro PM, 'Timing of chlamydial infection relative to allergen exposure differentially affects allergic airways disease', Respirology (TSANZ Abstracts-Posters), Auckland (2007) [E3]
Co-authorsPhilip Hansbro, Jay Horvat, Peter Gibson
2007Simosn L, Ellyard JI, Dent LA, Matthaei KI, Rothenberg ME, Foster PS, et al., 'Potential role for eosinophils in tumor immune surveillance', Proceedings of the 13th International Congress on Immunology, Rio de Janeiro, Brazil (2007) [E1]
2007Forbes EE, Groschwitz KR, Ahrens R, Brandt EB, Rothenberg ME, Foster PS, et al., 'Role of Th2-molecules in OVA-induced intestinal anaphylaxis', Journal of Allergy and Clinical Immunology (Program and Abstracts of Papers to be Presented During Scientific Sessions - 2007 AAAAI Annual Meeting), San Diego, California (2007) [E3]
DOI10.1016/j.jaci.2006.11.660
2006Forbes EE, Matthaei KI, Newhouse MJ, Foster PS, Hogan SP, 'Gastrointestinal allergic inflammation: IL-9, mast cells and intestinal anaphylaxis', JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Miami Beach, FL (2006)
DOI10.1016/j.jaci.2005.12.345Author URL
2006Dixon CM, Christie J, Matthaei KI, Foster PS, Webb DC, 'Identification & characterisation of proteins associated with allergic airways disease (AAD)', JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Miami Beach, FL (2006)
DOI10.1016/j.jaci.2005.12.608Author URL
2006Kaiko GE, Phipps S, Lam CE, Hickey DK, Hansbro NG, Foster PS, Beagley KW, 'The chlamydia infection of dendritic cells drives the development of a pro-asthmatic response', Immunology and Cell Biology, Auckland, NZ (2006) [E3]
Co-authorsNicole Hansbro
2006Horvat JC, Preston JA, Gibson PG, Beagley KW, Foster PS, Hansbro PM, 'Exacerbation of Allergic Airways Disease (AAD) by Chlamydia is Differentially Affected by the Timing of Infection Relative to Allergen Exposure', Immunology and Cell Biology, Auckland, NZ (2006) [E3]
Co-authorsJay Horvat, Philip Hansbro, Peter Gibson
2006Preston JA, Horvat JC, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'Streptococcus pneumoniae (SPN) lung infection suppresses hallmark features of a mouse model of asthma', Immunology and Cell Biology, Auckland, NZ (2006) [E3]
Co-authorsPeter Gibson, Philip Hansbro, Jay Horvat
2006Horvat JC, Moller CG, Wade MA, Preston JA, Hansbro NG, Gibson PG, et al., 'The development of allergic airways disease (AAD) is differently affected by chlamydial lung infection at different stages of life', Immunology and Cell Biology, Auckland, NZ (2006) [E3]
Co-authorsJay Horvat, Peter Gibson, Nicole Hansbro, Philip Hansbro
2006Mattes J, Simpson JL, Foster PS, Gibson PG, 'Trail is upregulated in the airways of asthmatics', Respirology, Canberra (2006) [E3]
Co-authorsPeter Gibson, Joerg Mattes, Jodie Simpson
2006Horvat JC, Wade MA, Preston JA, Hansbro NG, Gibson PG, Beagley KW, et al., 'Early life chlamydial lung infection enhances allergic airways disease (AAD)', Respirology, Canberra (2006) [E3]
Co-authorsPeter Gibson, Jay Horvat, Nicole Hansbro, Philip Hansbro
2006Preston JA, Horvat JC, Wade MA, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'Inhibition of allergic lung disease by respiratory streptococcus pneumoniae infection', Respirology, Canberra (2006) [E3]
Co-authorsPhilip Hansbro, Peter Gibson, Jay Horvat
2006Horvat JC, Wade MA, Preston JA, Hansbro NG, Gibson PG, Beagley KW, et al., 'Neonatal chlamydial infection exacerbates allergic airways disease', Abstracts ATS 2006 International Conference, San Diego, California (2006) [E3]
Co-authorsNicole Hansbro, Peter Gibson, Jay Horvat, Philip Hansbro
2006Preston JA, Horvat JC, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'Respiratory Streptococcus pneumoniae infection decreases key inflammatory responses in a mouse model of asthma', Abstracts ATS 2006 International Conference, San Diego, California (2006) [E3]
Co-authorsPeter Gibson, Philip Hansbro, Jay Horvat
2006Preston JA, Horvat JC, Wade MA, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'Inhibition of allergic lung disease by respiratory Streptococcus pneumoniae infection', 5th International Symposium on Pneumococci and Pneumococcal Diseases, Alice Springs (2006) [E3]
Co-authorsPeter Gibson, Jay Horvat, Philip Hansbro
2006Preston JA, Horvat JC, Wade MA, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'The influence of allergic airways disease on the immune response to respiratory Streptococcus pneumoniae infection', 5th International Symposium on Pneumococci and Pneumococcal Diseases, Alice Springs (2006) [E3]
Co-authorsJay Horvat, Philip Hansbro, Peter Gibson
2005Phipps S, Lam E, Newhouse M, Mahalingam S, Foster PS, Matthaei KI, 'Eosinophils Contribute to Antiviral Immunity Through the Expression of TLR7', 'Genetics and The Immune Response' Abstracts of the 35th Annual Scientific Meeting of the Australasian Society for Immunology and 14th International HLA & Immunogenetics Workshop, Melbourne (2005) [E3]
DOI10.1111/j.1399-0039.2005.00523.x
2005Preston JA, Horvat JC, Wade MA, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'Respiratory streptococcus pneumoniae infection decreases key inflammatory responses in a mouse model of asthma', TISSUE ANTIGENS, Melbourne, AUSTRALIA (2005)
Author URL
Co-authorsJay Horvat, Peter Gibson, Philip Hansbro
2005Horvat JC, Wade MA, Preston JA, Newcombe N, Ferguson AL, Kaiko G, et al., 'Neonatal But Not Adult Chlamydial Infection Induces the Development of Allergic Airways Disease Through Novel Mechanisms Involving Inflammation of Mixed Phenotype', Tissue Antigens, Melbourne, Australia (2005) [E3]
CitationsWeb of Science - 1
Co-authorsPhilip Hansbro, Jay Horvat, Peter Gibson
2005Horvat JC, Preston JA, Hansbro NG, Ferguson AL, Gibson PG, Beagley KW, et al., 'Neonatal chlamydial infection inhibits the development of allergic airway inflammation in adult mice', Inflammation Research, Melbourne, Australia (2005) [E3]
Co-authorsPhilip Hansbro, Peter Gibson, Nicole Hansbro, Jay Horvat
2005Preston JA, Horvat JC, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'Timing of Streptococcus Pneumoniae (pnc) infection determines the magnitute of the effect on allergic airways inflammation (AAI) in a mouse model of asthma', Respirology, Perth Convention Exhibition Centre (2005) [E3]
Co-authorsJay Horvat, Peter Gibson, Philip Hansbro
2005Preston JA, Horvat JC, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'Respiratory Streptococcus Pneumoniae Infection Decreases Eosinophilia and Mucus Cell Hyperplasia in a Mouse Model of Asthma', Respirology, Perth Convention Exhibition Centre (2005) [E3]
Co-authorsPeter Gibson, Philip Hansbro, Jay Horvat
2001Mahalingam S, Karupiah G, Takeda K, Akira S, Matthaei K, Foster PS, 'Enhanced resistance in STAT6-deficient mice to infection with ectromelia virus', Proceedings of the National Academy of Sciences of the United States of America, . (2001) [E1]
CitationsScopus - 16Web of Science - 14
2000Hogan S, Mishra A, Brandt E, Foster PS, Rothenberg M, 'A critical role for eotaxin in experimental oral antigen-induced eosinophilic gastrointestinal allergy', Proceedings of the National Academy of Sciences of the United States of America, . (2000) [E1]
CitationsScopus - 110Web of Science - 99
2000Simson L, Foster PS, 'Chemokine and cytokine cooperativity: Eosinophil migration in the asthmatic response', Immunology and Cell Biology, . (2000) [E1]
CitationsScopus - 27Web of Science - 24
1998Hogan S, Foster PS, Charlton B, Slattery R, 'Prevention of Th2-mediated murine allergic airways disease by soluble antigen administration in the neonate', Proceedings of the National Academy of Sciences of the United States of America, . (1998) [E1]
CitationsScopus - 13Web of Science - 12
1998Hogan S, Mould A, Young J, Rothenberg M, Ramsay A, Matthaei K, et al., 'Cellular and molecular regulation of eosinophil trafficking to the lung', Immunology and Cell Biology, . (1998) [E1]
CitationsScopus - 25Web of Science - 25
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Edit

Grants and Funding

Summary

Number of grants86
Total funding$19,406,566

Click on a grant title below to expand the full details for that specific grant.


201410 grants / $3,062,541

Characterising the immune function of a newly discovered CD4 T helper cell (Th22) and understanding its role in allergic inflammation$690,558

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamLaureate Professor Paul Foster
SchemeProject Grant
RoleLead
Funding Start2014
Funding Finish2014
GNoG1300109
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

New way of treating respiratory infections and airway inflammatory diseases by targeting miRNA $677,562

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamLaureate Professor Paul Foster, Doctor Ming Yang
SchemeProject Grant
RoleLead
Funding Start2014
Funding Finish2014
GNoG1300121
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Toll-like receptor 7 and asthma $673,712

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Joerg Mattes, Laureate Professor Paul Foster, Conjoint Professor Peter Wark
SchemeProject Grant
RoleInvestigator
Funding Start2014
Funding Finish2014
GNoG1300093
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

How resident host defence cells contribute to the development of childhood asthma and severe attacks of asthma $587,562

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamLaureate Professor Paul Foster, Professor Rakesh Kumar
SchemeProject Grant
RoleLead
Funding Start2014
Funding Finish2014
GNoG1300100
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Expanding the Genomic Frontier - from Species to Strains and Individuals to Populations$150,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Marc Wilkins, Professor Rick Cavicchioli, Professor Brett Neilan, Professor Rodney Scott, Laureate Professor Paul Foster, Associate Professor Phillip Dickson, Professor Ian Charles, Associate Professor Elizabeth Harry, Associate Professor Steven Djordjevic, Associate Professor Cynthia Whitchurch, Professor Ian Paulsen, Professor Nicolle Packer, Professor Michael Gillings
SchemeEquipment Grant
RoleInvestigator
Funding Start2014
Funding Finish2014
GNoG1300426
Type Of FundingInternal
CategoryINTE
UONY

Expanding the Genomic Frontier - from Species to Strains and Individuals to Populations$128,147

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamProfessor Marc Wilkins, Professor Rick Cavicchioli, Professor Brett Neilan, Professor Rodney Scott, Laureate Professor Paul Foster, Associate Professor Phillip Dickson, Professor Ian Paulsen, Professor Nicolle Packer, Professor Michael Gillings, Professor Ian Charles, Associate Professor Elizabeth Harry, Associate Professor Steven Djordjevic, Associate Professor Cynthia Whitchurch
SchemeLinkage Infrastructure Equipment & Facilities (LIEF)
RoleInvestigator
Funding Start2014
Funding Finish2014
GNoG1301339
Type Of FundingScheme excluded from IGS
CategoryEXCL
UONY

The Nanostring nCounter System$75,000

Funding body: Ramaciotti Foundations

Funding bodyRamaciotti Foundations
Project TeamProfessor Darryl Knight, Professor Phil Hansbro, Laureate Professor Paul Foster, Professor Rodney Scott, Conjoint Professor Peter Gibson, Professor Michael Nilsson
SchemeMajor Equipment Award
RoleInvestigator
Funding Start2014
Funding Finish2014
GNoG1300853
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

The Nanostring nCounter System$40,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamProfessor Darryl Knight, Professor Phil Hansbro, Laureate Professor Paul Foster, Professor Rodney Scott, Conjoint Professor Peter Gibson, Professor Michael Nilsson
SchemeEquipment Grant
RoleInvestigator
Funding Start2014
Funding Finish2014
GNoG1301083
Type Of FundingOther Public Sector - State
Category2OPS
UONY

The Nanostring nCounter System$20,000

Funding body: John Hunter Hospital Charitable Trust Fund

Funding bodyJohn Hunter Hospital Charitable Trust Fund
Project TeamProfessor Darryl Knight, Professor Phil Hansbro, Laureate Professor Paul Foster, Professor Rodney Scott, Conjoint Professor Peter Gibson, Professor Michael Nilsson
SchemeResearch Grant
RoleInvestigator
Funding Start2014
Funding Finish2014
GNoG1301084
Type Of FundingOther Public Sector - State
Category2OPS
UONY

Virus Infections Change the Bone Marrow: Effects on Immunity, Bone Development and Inflammatory Disease$20,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Steven Maltby, Mr Max Plank, Doctor Hock Tay, Laureate Professor Paul Foster
SchemeProject Grant
RoleInvestigator
Funding Start2014
Funding Finish2014
GNoG1401394
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

20134 grants / $1,020,342

HMRI MRSP Infrastructure (12-16) - VIVA Program$973,342

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamLaureate Professor Paul Foster, Conjoint Professor Peter Gibson
SchemeNSW MRSP Infrastructure Grant
RoleLead
Funding Start2013
Funding Finish2013
GNoG1300567
Type Of FundingOther Public Sector - State
Category2OPS
UONY

Molecular and cellular characterisation of TLR7 signalling in rhinovirus-induced asthma exacerbation$25,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamProfessor Joerg Mattes, Laureate Professor Paul Foster
SchemeNear Miss
RoleInvestigator
Funding Start2013
Funding Finish2013
GNoG1300692
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

DP73 Digital colour and monochrome camera + cellSens software + Xcite120 fluorescence lamp illuminator$20,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamLaureate Professor Paul Foster, Doctor Alan Hsu, Professor Phil Hansbro, Professor Joerg Mattes, Doctor Katie Baines, Associate Professor Jodie Simpson, Professor Rakesh Kumar, Doctor Nicole Hansbro, Doctor Steven Maltby, Doctor Ming Yang, Doctor Gerard Kaiko, Doctor Jay Horvat, Doctor Simon Keely, Doctor Andrew Jarnicki, Doctor Michael Fricker
SchemeEquipment Grant
RoleLead
Funding Start2013
Funding Finish2013
GNoG1201186
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

American Academy of Allergy Asthma & Immunology Annual Meeting, Henry B Gonzalez Convention Centre, San Antonio USA, 22 - 26 February 2013$2,000

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding bodyUniversity of Newcastle - Faculty of Health and Medicine
Project TeamLaureate Professor Paul Foster
SchemeTravel Grant
RoleLead
Funding Start2013
Funding Finish2013
GNoG1300349
Type Of FundingInternal
CategoryINTE
UONY

201211 grants / $2,174,035

Targeting miRNA to inhibit leukocyte differentiation: a novel anti-inflammatory approach for the treatment of asthma$590,886

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamLaureate Professor Paul Foster, Professor Ian Young
SchemeProject Grant
RoleLead
Funding Start2012
Funding Finish2012
GNoG1100129
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Understanding the mechanisms of steroid resistant inflammatory pathways in mouse models of asthma: potential new treatment approaches$514,551

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamLaureate Professor Paul Foster, Doctor Ming Yang
SchemeProject Grant
RoleLead
Funding Start2012
Funding Finish2012
GNoG1100099
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

HMRI MRSP Infrastructure (11-12)- VIVA$486,671

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamLaureate Professor Paul Foster, Conjoint Professor Peter Gibson
SchemeNSW MRSP Infrastructure Grant
RoleLead
Funding Start2012
Funding Finish2012
GNoG1101137
Type Of FundingOther Public Sector - State
Category2OPS
UONY

BD FACSAria III Cell Sorter: 3 laser 10-colour Flow Cytometer$180,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamLaureate Professor Paul Foster, Conjoint Professor Peter Gibson, Laureate Professor John Aitken, Professor Roger Smith, Professor Rodney Scott
SchemeLinkage Infrastructure Equipment & Facilities (LIEF)
RoleLead
Funding Start2012
Funding Finish2012
GNoG1100746
Type Of FundingScheme excluded from IGS
CategoryEXCL
UONY

BD FACSAria III Cell Sorter: 3 laser 10-colour Flow Cytometer$150,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamLaureate Professor Paul Foster, Professor Trevor Day, Conjoint Professor Peter Gibson, Laureate Professor John Aitken, Professor Roger Smith, Professor Rodney Scott
SchemeEquipment Grant
RoleLead
Funding Start2012
Funding Finish2012
GNoG1100744
Type Of FundingInternal
CategoryINTE
UONY

BD FACSAria III Cell Sorter: 3 laser 10-colour Flow Cytometer$122,927

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamLaureate Professor Paul Foster, Conjoint Professor Peter Gibson, Laureate Professor John Aitken, Professor Roger Smith, Professor Rodney Scott
SchemeProject Grant
RoleLead
Funding Start2012
Funding Finish2012
GNoG1200668
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

SpectraMax M5e Multi-Mode Microplate Reader$50,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamLaureate Professor Paul Foster, Professor Phil Hansbro, Professor Joerg Mattes, Professor Rakesh Kumar, Doctor Nicole Hansbro, Doctor Ming Yang, Doctor Jay Horvat, Doctor Simon Keely, Doctor Andrew Jarnicki, Doctor Linda Howland, Doctor Kelly Asquith
SchemeEquipment Grant
RoleLead
Funding Start2012
Funding Finish2012
GNoG1100975
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

Australia-Harvard Fellowship$36,000

Funding body: Harvard Club of Australia Foundation

Funding bodyHarvard Club of Australia Foundation
Project TeamLaureate Professor Paul Foster
SchemeAustralia-Harvard Fellowships
RoleLead
Funding Start2012
Funding Finish2012
GNoG1200214
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

Australia-Harvard Fellowship - Allen$26,000

Funding body: Harvard Club of Australia Foundation

Funding bodyHarvard Club of Australia Foundation
Project TeamLaureate Professor Paul Foster
SchemeAustralia-Harvard Fellowships
RoleLead
Funding Start2012
Funding Finish2012
GNoG1200238
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

Elucidating the mechanisms of steroid-resistant asthma$15,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Jay Horvat, Professor Phil Hansbro, Laureate Professor Paul Foster
SchemeResearch Grant
RoleInvestigator
Funding Start2012
Funding Finish2012
GNoG1200190
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

American Academy of Allergy Asthma and Immunology Annual Meeting 2012, Orlando, Florida, 2 - 6 March 2012$2,000

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding bodyUniversity of Newcastle - Faculty of Health and Medicine
Project TeamLaureate Professor Paul Foster
SchemeTravel Grant
RoleLead
Funding Start2012
Funding Finish2012
GNoG1200407
Type Of FundingInternal
CategoryINTE
UONY

201111 grants / $3,113,902

Targeting microRNA (miRNA) as a unified therapeutic approach to the treatment of asthma and allergic inflammation$651,732

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamLaureate Professor Paul Foster, Professor Joerg Mattes, Professor Rakesh Kumar
SchemeProject Grant
RoleLead
Funding Start2011
Funding Finish2011
GNoG1000262
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Mast cell proteases suppress respiratory viral infections and allergic inflammation of the airways$642,561

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamLaureate Professor Paul Foster, Dr Michele Grimbaldeston
SchemeProject Grant
RoleLead
Funding Start2011
Funding Finish2011
GNoG1000260
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Establishment of a comprehensive regional biophysical analysis facility $500,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamProfessor Peter Lewis, Professor Nicholas Dixon, Professor Eileen McLaughlin, Professor Adam McCluskey, Associate Professor Aaron Oakley, Laureate Professor Paul Foster, Laureate Professor John Aitken, Associate Professor Jennifer Beck, Dr Michael Kelso, Professor Graham Nicholson, Associate Professor Elizabeth Harry, Professor Ian Charles, Associate Professor Steven Djordjevic
SchemeLinkage Infrastructure Equipment & Facilities (LIEF)
RoleInvestigator
Funding Start2011
Funding Finish2011
GNoG1000630
Type Of FundingScheme excluded from IGS
CategoryEXCL
UONY

HMRI MRSP Infrastructure Grant (10-11) VIVA$485,452

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamConjoint Professor Peter Gibson, Laureate Professor Paul Foster
SchemeNSW MRSP Infrastructure Grant
RoleInvestigator
Funding Start2011
Funding Finish2011
GNoG1100162
Type Of FundingOther Public Sector - State
Category2OPS
UONY

Development of microbial bioproducts for the suppression of inflammation$285,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamProfessor Phil Hansbro, Laureate Professor Paul Foster, Professor Rakesh Kumar
SchemeDiscovery Projects
RoleInvestigator
Funding Start2011
Funding Finish2011
GNoG1000021
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Establishment of a comprehensive regional biophysical analysis facility $230,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamProfessor Peter Lewis, Professor Nicholas Dixon, Professor Eileen McLaughlin, Professor Adam McCluskey, Associate Professor Aaron Oakley, Laureate Professor Paul Foster, Laureate Professor John Aitken, Associate Professor Jennifer Beck, Dr Michael Kelso, Professor Graham Nicholson, Associate Professor Elizabeth Harry, Professor Ian Charles, Associate Professor Steven Djordjevic
SchemeLinkage Infrastructure Equipment & Facilities (LIEF) Partner funding
RoleInvestigator
Funding Start2011
Funding Finish2011
GNoG1100484
Type Of FundingScheme excluded from IGS
CategoryEXCL
UONY

DVCR Special Grant 2011$140,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamLaureate Professor Paul Foster
SchemeSpecial Project Grant
RoleLead
Funding Start2011
Funding Finish2011
GNoG1101011
Type Of FundingInternal
CategoryINTE
UONY

Research microscope, confocal ready nikon eclipse 90i microscope$69,157

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Roger Smith, Conjoint Professor Tam Zakar, Professor Jon Hirst, Doctor Kaushik Maiti, Doctor Gemma Madsen, Professor Rodney Scott, Conjoint Professor Peter Wark, Laureate Professor Paul Foster, Professor Phil Hansbro, Conjoint Professor Ian Wright
SchemeEquipment Grant
RoleInvestigator
Funding Start2011
Funding Finish2011
GNoG1100024
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

Maitland Cancer Appeal Committee Donation - Lung Cancer Mouse Model$50,000

Funding body: Maitland Cancer Appeal Committee

Funding bodyMaitland Cancer Appeal Committee
Project TeamProfessor Phil Hansbro, Laureate Professor Paul Foster, Doctor Gough Au
SchemeResearch Project
RoleInvestigator
Funding Start2011
Funding Finish2011
GNoG1100246
Type Of FundingDonation - Aust Non Government
Category3AFD
UONY

SCIREQ FlexiVentFX system + FlexiVentFX extension$45,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Phil Hansbro, Laureate Professor Paul Foster, Professor Joerg Mattes, Doctor Simon Keely, Doctor Jay Horvat, Doctor Nicole Hansbro, Doctor Ming Yang, Doctor Catherine Ptaschinski, Doctor Kelly Asquith, Doctor Gough Au, Conjoint Professor Peter Wark, Laureate Professor John Aitken, Conjoint Professor Keith Jones, Professor Roger Smith, Professor Judith Black, Professor Rakesh Kumar, Professor Paul Hertzog
SchemeEquipment Grant
RoleInvestigator
Funding Start2011
Funding Finish2011
GNoG1100037
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

Sparke Helmore/NBN Triathlon Award for Research Excellence$15,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamLaureate Professor Paul Foster
SchemeSparke Helmore/NBN Television Corporate Triathlon Award for Research Excellence
RoleLead
Funding Start2011
Funding Finish2011
GNoG1000985
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

20108 grants / $1,847,788

The role of microRNAs in the regulation of antiviral and inflammatory responses during experimental rhinovirus infection$583,500

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Joerg Mattes, Laureate Professor Paul Foster
SchemeProject Grant
RoleInvestigator
Funding Start2010
Funding Finish2010
GNoG0190183
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

HMRI MRSP Infrastructure Grant (09-10) - VIVA$397,696

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamLaureate Professor Paul Foster, Conjoint Professor Peter Gibson
SchemeNSW MRSP Infrastructure Grant
RoleLead
Funding Start2010
Funding Finish2010
GNoG1000232
Type Of FundingOther Public Sector - State
Category2OPS
UONY

Mechanisms of induction and progression of childhood asthma: investigations in a mouse model $240,750

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Rakesh Kumar, Laureate Professor Paul Foster, Dr Megan Hitchins
SchemeProject Grant
RoleLead
Funding Start2010
Funding Finish2010
GNoG0900216
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Buxco FinePointe software and FinePointe RC system for mice $39,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamLaureate Professor Paul Foster, Professor Phil Hansbro, Professor Joerg Mattes, Doctor Nicole Hansbro, Doctor Simon Phipps, Doctor Ming Yang, Doctor Kelly Asquith, Doctor Catherine Ptaschinski, Professor Rakesh Kumar, Professor Judith Black
SchemeEquipment Grant
RoleLead
Funding Start2010
Funding Finish2010
GNoG1000053
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

Molecular markers of reversible airway obstruction in early life and correlation with clinical wheezing patterns$19,842

Funding body: Hunter Children`s Research Foundation

Funding bodyHunter Children`s Research Foundation
Project TeamProfessor Joerg Mattes, Laureate Professor Paul Foster, Conjoint Associate Professor Bruce Whitehead, Doctor Ana Pereira De Siqueira
SchemeResearch Grant
RoleInvestigator
Funding Start2010
Funding Finish2010
GNoG0900119
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

The 8th Asia Pacific Congress of Allergy, Asthma and Clinical Immunology, Singapore, 6 - 9 November 2010$2,000

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding bodyUniversity of Newcastle - Faculty of Health and Medicine
Project TeamLaureate Professor Paul Foster
SchemeTravel Grant
RoleLead
Funding Start2010
Funding Finish2010
GNoG1000937
Type Of FundingInternal
CategoryINTE
UONY

20095 grants / $630,650

Coulter counter$41,150

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamLaureate Professor Paul Foster, Professor Phil Hansbro, Professor Joerg Mattes, Doctor Simon Phipps, Doctor Ming Yang, Doctor Nicole Hansbro, Doctor Kelly Asquith
SchemeEquipment Grant
RoleLead
Funding Start2009
Funding Finish2009
GNoG0189851
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

Development of novel therapeutic approaches for rhinovirus - induced asthma exacerbation$24,500

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamProfessor Joerg Mattes, Laureate Professor Paul Foster, Conjoint Professor Peter Wark
SchemeProject Grant
RoleInvestigator
Funding Start2009
Funding Finish2009
GNoG0189800
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Immunisation against chlamydia-associated asthma$20,000

Funding body: Rebecca L Cooper Medical Research Foundation Ltd

Funding bodyRebecca L Cooper Medical Research Foundation Ltd
Project TeamDoctor Jay Horvat, Professor Phil Hansbro, Laureate Professor Paul Foster
SchemeResearch Grant
RoleInvestigator
Funding Start2009
Funding Finish2009
GNoG0189629
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

20087 grants / $2,045,882

The role of microRNAs as new anti-inflammatory targets for the treatment of asthma$600,375

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamLaureate Professor Paul Foster, Professor Rakesh Kumar, Assoc. Prof Klaus Matthaei, Professor Joerg Mattes
SchemeProject Grant
RoleLead
Funding Start2008
Funding Finish2008
GNoG0187584
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Targeting the shared beta-chain of the IL-3, IL-5 and GM-CSF receptors as therapy for allergic inflammation$585,375

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamLaureate Professor Paul Foster, Professor Angel Lopez
SchemeProject Grant
RoleLead
Funding Start2008
Funding Finish2008
GNoG0187585
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

The mechanisms underlying pneumoviral-induced angiogenesis of the lung and its impact on the asthmatic response$541,875

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamLaureate Professor Paul Foster, Professor Judith Black
SchemeProject Grant
RoleLead
Funding Start2008
Funding Finish2008
GNoG0187591
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Role of IL-3 in allergic inflammation: modulation of basophils, mast cells, eosinophils and remodelling in asthma$235,050

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamLaureate Professor Paul Foster
SchemeProject Grant
RoleLead
Funding Start2008
Funding Finish2008
GNoG0189190
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Individually ventilated cages (IVC) and associated ventilator, holding boxes and water bottles$35,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamLaureate Professor Paul Foster, Professor Phil Hansbro, Professor Joerg Mattes, Doctor Simon Phipps, Doctor Ming Yang, Doctor Nicole Hansbro, Doctor Kelly Asquith
SchemeEquipment Grant
RoleLead
Funding Start2008
Funding Finish2008
GNoG0188541
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

MicroRNA and antagomirs in the regulation and suppression of interferon (IFN)-g and lipopolysaccharide (LPS) induced steroid-resistant airways hyperreactivity$24,250

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Ming Yang, Laureate Professor Paul Foster
SchemeProject Grant
RoleInvestigator
Funding Start2008
Funding Finish2008
GNoG0188474
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Therapeutic potential of targeting the IL-3/IL-5/GM-CSF common beta receptor to treat allergic inflammation and asthma$23,957

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Kelly Asquith, Laureate Professor Paul Foster
SchemeProject Grant
RoleInvestigator
Funding Start2008
Funding Finish2008
GNoG0188460
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

20079 grants / $1,114,488

HMRI - Viruses, Infection/Immunity, Vaccines and Asthma Research Program$692,213

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamLaureate Professor Paul Foster, Conjoint Professor Peter Gibson, Conjoint Professor Stephen Graves, Associate Professor Darren Shafren
SchemeNSW MRSP Infrastructure Grant
RoleLead
Funding Start2007
Funding Finish2007
GNoG0187930
Type Of FundingOther Public Sector - State
Category2OPS
UONY

Influence of early-life viral infection on severity of murine chronic asthma and acute exacerbations$231,750

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamLaureate Professor Paul Foster, Professor Rakesh Kumar
SchemeProject Grant
RoleLead
Funding Start2007
Funding Finish2007
GNoG0187409
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Differential regulation of human mast cell degranulation by discrete forms of protein phosphatase 2A$50,000

Funding body: Asthma Foundation of New South Wales

Funding bodyAsthma Foundation of New South Wales
Project TeamProfessor Alistair Sim, Doctor Nikki Verrills, Laureate Professor Paul Foster, Conjoint Professor Peter Wark, Conjoint Professor Peter Gibson, Dr Gregory Kranias
SchemeResearch Grant
RoleInvestigator
Funding Start2007
Funding Finish2007
GNoG0187247
Type Of FundingDonation - Aust Non Government
Category3AFD
UONY

Nitric Oxide Monitoring System (NIOX)$45,000

Funding body: NHMRC (National Health & Medical Research Council)

Elucidation of the association between Haemophilus influenzae infection and neutrophilic asthma.$20,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamProfessor Phil Hansbro, Associate Professor Jodie Simpson, Laureate Professor Paul Foster, Conjoint Professor Margaret Dunkley
SchemeProject Grant
RoleInvestigator
Funding Start2007
Funding Finish2007
GNoG0187206
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

The role of tumstatin in angiogenesis and asthma$20,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamLaureate Professor Paul Foster, Doctor Nicole Hansbro, Doctor Simon Phipps, Professor Phil Hansbro
SchemeProject Grant
RoleLead
Funding Start2007
Funding Finish2007
GNoG0187238
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Hewlett Packard 7890 series gas chromatograph with accessories$20,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamAssociate Professor Lisa Wood, Conjoint Professor Peter Wark, Conjoint Professor Peter Gibson, Associate Professor Jodie Simpson, Doctor Vanessa Murphy, Laureate Professor Paul Foster, Professor Phil Hansbro, Conjoint Associate Professor Vicki Clifton, Professor Clare Collins, Conjoint Professor Wayne Smith, Professor John Attia
SchemeEquipment Grant
RoleInvestigator
Funding Start2007
Funding Finish2007
GNoG0188191
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

Class II biohazard containment hood and carbon dioxide cell culture incubator$20,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamConjoint Professor Peter Wark, Conjoint Professor Peter Gibson, Associate Professor Jodie Simpson, Doctor Vanessa Murphy, Associate Professor Lisa Wood, Laureate Professor Paul Foster, Professor Phil Hansbro
SchemeEquipment Grant
RoleInvestigator
Funding Start2007
Funding Finish2007
GNoG0188192
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

The prevention and treatment of Asthma with a diet high in seafood content$15,525

Funding body: Seafood Services Australia

Funding bodySeafood Services Australia
Project TeamProfessor Phil Hansbro, Laureate Professor Paul Foster
SchemeSeafood Industry Development Fund
RoleInvestigator
Funding Start2007
Funding Finish2007
GNoG0185404
Type Of FundingAust Competitive - Non Commonwealth
Category1NS
UONY

20068 grants / $918,744

PRC Priority Research Centre for Asthma & Respiratory Diseases$524,282

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamLaureate Professor Paul Foster, Conjoint Professor Peter Gibson, Conjoint Professor Kenneth Beagley, Emeritus Professor Michael Hensley, Professor Phil Hansbro, Professor Joerg Mattes, Professor Alistair Sim, Conjoint Professor Peter Wark
SchemePriority Research Centre
RoleLead
Funding Start2006
Funding Finish2006
GNoG0186914
Type Of FundingInternal
CategoryINTE
UONY

Surveillance and Analysis of Avian Influenza Viruses in Migratory Birds in Australia$249,625

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Phil Hansbro, Dr Ian Barr, Conjoint Professor Peter Wark, Dr Paul Selleck, Dr Simone Warner, Laureate Professor Paul Foster, Dr Aeron Hurt, Dr Irene Peroulis, Dr John Curran, Conjoint Professor Peter Gibson
SchemePotential Avian Influenza-Induced Pandemic
RoleInvestigator
Funding Start2006
Funding Finish2006
GNoG0186000
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Targeting protein phosphatases to control mast cell activation$50,000

Funding body: Asthma Foundation of New South Wales

Funding bodyAsthma Foundation of New South Wales
Project TeamProfessor Alistair Sim, Laureate Professor Paul Foster
SchemeResearch Grant
RoleInvestigator
Funding Start2006
Funding Finish2006
GNoG0186027
Type Of FundingDonation - Aust Non Government
Category3AFD
UONY

CD4+T-cell programming in early life and neonatal infection.$25,000

Funding body: GlaxoSmithKline Australia

Funding bodyGlaxoSmithKline Australia
Project TeamLaureate Professor Paul Foster, Ms Angela Ferguson
SchemeSupport Grant
RoleLead
Funding Start2006
Funding Finish2006
GNoG0186837
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Identification of early-life signals induced in response to infection that predispose to asthma in later life$20,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Phil Hansbro, Laureate Professor Paul Foster, Conjoint Professor Kenneth Beagley, Professor Alistair Sim
SchemePilot Grant
RoleInvestigator
Funding Start2006
Funding Finish2006
GNoG0186699
Type Of FundingInternal
CategoryINTE
UONY

CD4 T Cell Programming by early life and neonatal infection$18,837

Funding body: Asthma Foundation of New South Wales

Funding bodyAsthma Foundation of New South Wales
Project TeamMs Angela Ferguson, Laureate Professor Paul Foster
SchemePhD Scholarships
RoleInvestigator
Funding Start2006
Funding Finish2006
GNoG0186002
Type Of FundingDonation - Aust Non Government
Category3AFD
UONY

Role of TRAIL on development of atopic dermatitis and T helper type 2 immunity$16,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamProfessor Joerg Mattes, Laureate Professor Paul Foster
SchemeProject Grant
RoleInvestigator
Funding Start2006
Funding Finish2006
GNoG0186098
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

CRC for asthma - shared with Monash University$15,000

Funding body: CRC for Asthma

Funding bodyCRC for Asthma
Project TeamLaureate Professor Paul Foster
SchemeResearch Grant
RoleLead
Funding Start2006
Funding Finish2006
GNoG0186654
Type Of FundingCRC - Cooperative Research Centre
Category4CRC
UONY

20057 grants / $2,604,586

Drug targets from new animal models$2,030,948

Funding body: CRC for Asthma

Funding bodyCRC for Asthma
Project TeamLaureate Professor Paul Foster, Professor Phil Hansbro, Professor Joerg Mattes, Doctor Ming Yang, Dr Simon Phipps
SchemeResearch Grant
RoleLead
Funding Start2005
Funding Finish2005
GNoG0185860
Type Of FundingCRC - Cooperative Research Centre
Category4CRC
UONY

CD4 T cell programming by neonatal and early-life infection$250,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamLaureate Professor Paul Foster, Conjoint Professor Kenneth Beagley, Professor Phil Hansbro
SchemeDiscovery Projects
RoleLead
Funding Start2005
Funding Finish2005
GNoG0184398
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Modulation of inflammatory responses in the asthmatic lung by Chlamydial infection$50,000

Funding body: Asthma Foundation of New South Wales

Funding bodyAsthma Foundation of New South Wales
Project TeamProfessor Phil Hansbro, Laureate Professor Paul Foster, Conjoint Professor Kenneth Beagley
SchemeResearch Grant
RoleInvestigator
Funding Start2005
Funding Finish2005
GNoG0185208
Type Of FundingDonation - Aust Non Government
Category3AFD
UONY

SealSafe Shelving Module IVC System & Slimline AHU Air Control Mobile Trolley$41,449

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamLaureate Professor Paul Foster
SchemeEquipment Grant
RoleLead
Funding Start2005
Funding Finish2005
GNoG0185470
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

Chlamydia infection of dendritic cells drives the development of pro-asthmatic Th2 cells$15,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamConjoint Professor Kenneth Beagley, Laureate Professor Paul Foster
SchemeProject Grant
RoleInvestigator
Funding Start2005
Funding Finish2005
GNoG0184898
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Prevention of asthma by immunisation with pneumococcal cell walls$10,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Phil Hansbro, Laureate Professor Paul Foster, Conjoint Professor Kenneth Beagley, Conjoint Professor Peter Gibson
SchemeProject Grant
RoleInvestigator
Funding Start2005
Funding Finish2005
GNoG0184712
Type Of FundingInternal
CategoryINTE
UONY

20046 grants / $873,608

Molecular Mechanisms in the Regulation of allergy and inflammation$663,608

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamLaureate Professor Paul Foster, Dr Simon Hogan, Assoc. Prof Klaus Matthaei, Professor Philip Thompson, Professor Ian Young
SchemeProgram Grant
RoleLead
Funding Start2004
Funding Finish2004
GNoG0184188
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Cytokines regulating airway inflammation, remodelling and hyper-reactivity in chronic asthma$110,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamLaureate Professor Paul Foster, Professor Rakesh Kumar, Dr Mark Raftery
SchemeProject Grant
RoleLead
Funding Start2004
Funding Finish2004
GNoG0184155
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Modulation of Asthma by bacterial infection or vaccination in different age groups$60,000

Funding body: Rebecca L Cooper Medical Research Foundation Ltd

Funding bodyRebecca L Cooper Medical Research Foundation Ltd
Project TeamProfessor Phil Hansbro, Laureate Professor Paul Foster, Conjoint Professor Kenneth Beagley
SchemeResearch Grant
RoleInvestigator
Funding Start2004
Funding Finish2004
GNoG0184154
Type Of FundingDonation - Aust Non Government
Category3AFD
UONY

Modulation of immune responses in asthma by bacterial infections during early life.$15,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Phil Hansbro, Laureate Professor Paul Foster, Conjoint Professor Peter Gibson
SchemeProject Grant
RoleInvestigator
Funding Start2004
Funding Finish2004
GNoG0183512
Type Of FundingInternal
CategoryINTE
UONY

Investigation of the role of eosinophils in regulating disease processes in asthma$15,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamLaureate Professor Paul Foster
SchemeNew Staff Grant
RoleLead
Funding Start2004
Funding Finish2004
GNoG0184841
Type Of FundingInternal
CategoryINTE
UONY

Chemokine-mediated enhancement of transcutaneous immunization to target genital and respiratory tract chlamydial infections$10,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamConjoint Professor Kenneth Beagley, Laureate Professor Paul Foster
SchemeProject Grant
RoleInvestigator
Funding Start2004
Funding Finish2004
GNoG0183467
Type Of FundingInternal
CategoryINTE
UONY
Edit

Research Supervision

Current Supervision

CommencedResearch Title / Program / Supervisor Type
2015Contribution of Cell Death to the Pathogenesis of Chronic Obstructive Pulmonary Disease (COPD)
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2015Novel Signalling Pathways in Food Allergy and Eosinophilic Oesophagitis
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2014Chronic Obstructive Pulmonary Disease (COPD)
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2013The Impact of Better Asthma Management during Pregnancy on the Lung Function of the Child
Paediatrics, Faculty of Health and Medicine
Co-Supervisor
2013Role of TLR/IL-13/STAT6/PI3K Response in Early-life Respiratory Infection and Infection-Induced Chronic Lung Disease
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2013Investigation of the pathogenesis and potential therapeutic interventions of influenza in Asthma and COPD
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2012The Role of Rhinovirus, TRAIL, IL-13 and PP2A in Allergic Airways Disease
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2012Investigating the Mechanisms of Tobacco Cigarette Smoke-Induced Lung Cancer
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2012The Role of TRAIL in the Induction and Perpetuation of Eosinophilic Oesophagitis
Paediatrics, Faculty of Health and Medicine
Co-Supervisor
2012Roles of Bromodomain and extra terminal (BET) proteins in Suppression of Airway Inflammation
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2012Understanding the mechanisms of airway hyper-responsiveness in a mouse model of asthma
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2012Assessing the Epigenetic Involvement in the Development and Progression of Chronic Obstructive Pulmonary Disease (COPD)
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2011The Role of Interferon Epsilon in Protection Against Chlamydial Reproductive Tract Infections
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2011Mechanisms of Predisposition to Secondary Bacterial Pneumonia
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2011The Role of Innate Cells in Infectious Exacerbation of COPD
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2011Investigation of Pathogenesis of Chronic Obstructive Pulmonary Disease (COPD)
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2011Immunoregulatory Therapies for Inflammatory Diseases
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2011The Roles of Fibulin-1 in Airway Remodelling in Lung Diseases
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2010Role of TRAIL and TLRT in Response to Rhinovirus Infection in Allergic Airways Disease
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2010Indentification of New Therapeutics in COPD/ Emphysema
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2009Mechanisms of Increased Susceptibility to Influenza Infection in Mouse Models of Chronic Lung Disease
Microbiology, Faculty of Health and Medicine
Co-Supervisor

Past Supervision

YearResearch Title / Program / Supervisor Type
2015Investigation of the Mechanisms of Respiratory Infection- Induced Lung Disease
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2014Immune Mechanisms that Underpin Early-Life Chlamydia Respiratory Infection-Induced Chronic Lung Disease
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2014Respiratory Innate Immune Factors Regulate Steroid-resistant Airway Hyperreactivity and Asthma
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2014The Role of microRNAs in Allergic Airways Disease and T Cell Biology
Microbiology, Faculty of Health and Medicine
Principal Supervisor
2014The Role of MicroRNA in Regulating Anti-Bacterial Responses in Innate Immune Cells
Microbiology, Faculty of Health and Medicine
Principal Supervisor
2013The Role of Early Life Infection on the Programming of CD4+ T-cells
Microbiology, Faculty of Health and Medicine
Principal Supervisor
2012Modulation of Responses in Allergic Airways Disease by Haemophilus Influenzae Infection
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2012Novel Therapeutic Approaches for the Treatment of Allergic Airways Disease
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2011The Innate Immune Mechanisms Underlying the Interplay Between Respiratory Infections and Asthma
Microbiology, Faculty of Health and Medicine
Principal Supervisor
2011Understanding the Inflammatory Mechanisms That Predispose to Emphysema in Mouse Models
Microbiology, Faculty of Health and Medicine
Principal Supervisor
2011Immune Mechanisms that Promote the Development of Inducible Bronchus-Associated Lymphoid Tissue (IBALT)
Microbiology, Faculty of Health and Medicine
Principal Supervisor
2009Nutritional Modulation of Lung Inflammation
Microbiology, Faculty of Health and Medicine
Principal Supervisor
2008Modulation of Responses in the Asthmatic Lung by Chlamydial Infection
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2007Modulation of Responses in the Asthmatic Lung by Streptococcus Pneumoniae
Microbiology, Faculty of Health and Medicine
Co-Supervisor
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News

Laureate Professor Paul Foster

Warrior immune cells could win the fight against asthma

May 5, 2014

University of Newcastle Laureate Professor Paul Foster is developing new anti-inflammatory approaches to treat asthma and infections of the lung. One promising approach is to boost the body's own defence systems against infections, especially against those that trigger asthma.

Laureate Professor John Aitken

Newcastle biologist named NSW Scientist of the Year

November 14, 2012

The University of Newcastle's Laureate Professor John Aitken has been named NSW Scientist of the Year at the 2012 NSW Science and Engineering awards in Sydney.

Person with asthma inhaler

Laureate Professor awarded top honour from ANU

July 13, 2012

Laureate Professor Paul Foster has been awarded a Doctor of Science degree (D.Sc.) from the Australian National University at a ceremony on Friday July 13th, 2012. This is a particularly prestigious award given the Australian National University is ranked as one of the top 50 Universities in the world.

Laureate Professor Paul Foster

Position

Laureate Professor
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

Focus area

Immunology and Microbiology

Contact Details

Emailpaul.foster@newcastle.edu.au
Phone(02) 4042 0163
Fax(02) 4042 0036

Office

Room2401 HMRI
BuildingHMRI
LocationOther

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