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Career Summary

Biography

Dr Nikola Bowden was appointed at the University of Newcastle in 2006 as the inaugural NBN Telethon childhood cancer post-doctoral fellow. Subsequent to this in 2008 she was awarded a Gladys M. Brawn memorial post-doctoral fellowship from the Faculty of Health, University of Newcastle. In January 2009 Dr Bowden was appointed as a Lecturer in the School of Biomedical Sciences & Pharmacy and was awarded an NH&MRC training (post-doctoral) fellowship which she commenced in October 2009. Since 2006, Dr Bowden has developed a research interest with the overall aim of delivering personalised diagnosis and treatment to patients with cancer, with a more focused interest in investigating DNA repair in melanoma. Dr Bowden's research has been funded through a nationally competitive fellowship and grants from the NH&MRC, Cure Cancer Australia Foundation and Cancer Australia, respectively. Dr Bowden collaborates with Dr Daniel Catchpoole at the Children’s Hospital at Westmead and has international collaborations with Prof James Cleaver from University of California San Francisco (USA) and Dr Javed Khan from the National Cancer Institute and National Institutes of Health (USA). Dr Bowden has obtained over $1,000,000 in funding, published 22 articles in international peer-reviewed journals and have presented her research over 60 times at international and national conferences. Dr Bowden currently supervises 4 research higher degree PhD students. Dr Bowden was awarded the University of Newcastle Young Alumni Award in 2011 and was part of a collaboration awarded the Schizophrenia Research Institute Research Paper Award in 2008 and was the recipient of the 2007 Hunter Children's Research Foundation (HCRF) Award for Research Excellence for her research into the DNA repair and skin cancer disorder, Xeroderma Pigmentosum, and childhood acute lymphoblastic leukaemia. In 2006, she was awarded the Hunter Medical Research Institute (HMRI) PULSE Education Prize, an award presented to an outstanding early career researcher. Dr Bowden has been an invited reviewer for the international funding body Medical Research Council (UK), and many international journals.

Qualifications

  • PhD, University of Newcastle, 04/10/2006
  • Bachelor of Biomedical Sciences, University of Newcastle, 14/12/2000
  • Bachelor of Biomedical Sciences (Hons), University of Newcastle, 14/11/2001

Research

Research keywords

  • Chemotherapy
  • DNA repair
  • Melanoma
  • UV-light

Research expertise

Below is a summary of my current research projects:

Nucleotide Excision Repair Gene Expression in Melanoma:

My main research program is investigating the role of DNA repair in cancer. The results of a pilot study into deficient DNA repair in melanoma have been published in the journal Cancer Research. The publication of this manuscript represents a shift in the central dogma surrounding DNA repair and melanoma. To date there has been a central belief that DNA repair is not involved in development of melanoma. The results of our study have now confirmed the hypothesis that a deficiency in DNA repair is indeed a feature of melanoma and may be the reason why melanomas develop after excessive sun exposure and why melanomas do not respond to common chemotherapeutic agents. The major outcome of this research program will be a biological explanation for why excessive sunlight exposure results in melanomagenesis and why melanomas do not respond to common DNA-damaging chemotherapeutic agents, two of the most elusive features of melanoma.

In addition, I collaborate with Dr Ricardo Vilain and Dr Stephen Braye from the Hunter Area Pathology Service (HAPS) Anatomocal Pathology department to utilise formalin-fixed paraffin embedded (FFPE) melanoma tissue collected and stored for diagnostic purposes. This tissue represents a very large cohort of individuals from the hunter region with melanoma and allows for retrospective analysis of clinical data such as disease recurrence, response to treatment and survival. Another major advantage of using this tissue is that it requires no direct participation from patients with melanoma thus lessening the burden of research on clinicians and patients. This collaboration was established in 2009 and the preliminary results of several projects have been presented at the 7th and 8th International Congress of the Society for Melanoma Research (2010 & 2011).

Languages

  • English

Fields of Research

CodeDescriptionPercentage
060199Biochemistry And Cell Biology Not Elsewhere Classified50
111299Oncology And Carcinogenesis Not Elsewhere Classified50

Memberships

Committee/Associations (relevant to research).

  • Member - Society for Melanoma Research
  • Member - American Association of Cancer Research
  • Member - Australian Society of Medical Research

NHMRC Committee

  • Member - Post-Doctoral Reference Group
  • Member - Research Translation Faculty

Appointments

Fellowship
National Health & Medical Research Council (Australia)
01/09/2009
Gladys M. Brawn Memorial Post Doctoral Fellow
University of Newcastle (Australia)
01/01/2008 - 01/12/2008
NBN Telethon Post-Doctoral Fellow
Hunter Medical Research Institute (Australia)
01/01/2006 - 01/12/2007

Awards

Other

2011Young Alumni Award
University of Newcastle (Australia)
Recognition of outstanding graduate of the University of Newcastle under 35 years.

Recognition.

2012Emerging Research Leaders Program
University of Newcastle (Australia)
Pro Vice-Chancellor (Research) program for future research leaders
2007INSIGHT
Hunter Medical Research Institute (Australia)
Development program for early-mid career researchers

Research Award.

2007Award for Research Excellence
Hunter Children's Research Foundation (Australia)
Annual award for excellence in research
2006PULSE Education Prize
Hunter Medical Research Institute (Australia)
2006Student Support Award to attend the International Congress on
Human Genetics Society of Australasia (Australia)
2004Student Travel Award
World Congress on Psychiatric Genetics (United States)
2003Student Travel Award
Australian Neuroscience Society (Australia)

Teaching

Teaching keywords

  • Genetics

Teaching expertise

The following is a summary of my major research training and teaching:

• Currently primary supervisor of 4 PhD students, co-supervisor of 3 PhD students. Previously supervised 3 !st Class Honours students.

• Supervised B. Biomedical Science 3rd year HUBS3409 students to undertake research project (2009 & 2011)

• Delivered the lectures and tutorials for the genetics and genomics component of the M. Pharmacy course PHAR6123 – Human Genomics and Biomolecular Analysis (2005, 2006, 2008, 2011, 2013)

• Delivered 6 lectures for B. Biomedical Science HUBS2409 Bioinformatics and Functional Genomics in 2008 and annual guest lectures in 2005-2006.

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Highlighted Publications

For publications that are currently unpublished or in-press, details are shown in italics.

YearCitationAltmetricsLink
2010Bowden NA, Ashton KA, Kiejda KA, Zhang XD, Hersey P, Scott R, 'Nucleotide excision repair gene expression after cisplatin treatment in melanoma', Cancer Research, 70 7918-7926 (2010) [C1]
2014Bowden NA, 'Nucleotide excision repair: Why is it not used to predict response to platinum-based chemotherapy?', Cancer Letters, 346 163-171 (2014)
2013Bowden NA, Ashton KA, Vilain RE, Avery-Kiejda KA, Davey RJ, Murray HC, et al., 'Regulators of Global Genome Repair Do Not Respond to DNA Damaging Therapy but Correlate with Survival in Melanoma', PLOS ONE, 8 (2013) [C1]
2013Budden T, Bowden NA, 'The Role of Altered Nucleotide Excision Repair and UVB-Induced DNA Damage in Melanomagenesis', INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 14 1132-1151 (2013) [C1]

Publications

For publications that are currently unpublished or in-press, details are shown in italics.

Click on a category title below to expand the list of citations for that specific category.

Journal article (30 outputs)

YearCitationAltmetricsLink
2014Evans TJ, Milne E, Anderson D, de Klerk NH, Jamieson SE, Talseth-Palmer BA, et al., 'Confirmation of childhood acute lymphoblastic leukemia variants, ARID5B and IKZF1, and interaction with parental environmental exposures.', PLoS One, 9 e110255 (2014)
2014Ashton KA, Scurry J, Ouveysi A, Ebbs J, Jaaback K, Bowden NA, 'Transformation of endometrioid carcinoma to carcinoma with trophoblastic differentiation: clinicopathological and whole genomic study.', Pathology, 46 351-353 (2014)
2014Bowden NA, 'Nucleotide excision repair: Why is it not used to predict response to platinum-based chemotherapy?', Cancer Letters, (2014)
2014Wan C, Latter JL, Amirshahi A, Symonds I, Finnie J, Bowden N, et al., 'Progesterone Activates Multiple Innate Immune Pathways in Chlamydia trachomatis-Infected Endocervical Cells', American Journal of Reproductive Immunology, 71 165-177 (2014)
2014Bowden NA, 'Nucleotide excision repair: Why is it not used to predict response to platinum-based chemotherapy?', Cancer Letters, 346 163-171 (2014)
2014Wong-Brown MW, Avery-Kiejda KA, Bowden NA, Scott RJ, 'Low prevalence of germline PALB2 mutations in Australian triple-negative breast cancer', International Journal of Cancer, 134 301-305 (2014)
2014Cox MB, Bowden NA, Scott RJ, Lechner-Scott J, 'Common genetic variants in the plasminogen activation pathway are not associated with multiple sclerosis.', Mult Scler, 20 489-491 (2014)
2014Wan C, Latter JL, Amirshahi A, Symonds I, Finnie J, Bowden N, et al., 'Progesterone Activates Multiple Innate Immune Pathways in Chlamydia trachomatis-Infected Endocervical Cells', AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 71 165-177 (2014)
2013Bowden NA, Ashton KA, Vilain RE, Avery-Kiejda KA, Davey RJ, Murray HC, et al., 'Regulators of Global Genome Repair Do Not Respond to DNA Damaging Therapy but Correlate with Survival in Melanoma', PLOS ONE, 8 (2013) [C1]
2013Cox MB, Bowden NA, Scott RJ, Lechner-Scott J, 'Altered expression of the plasminogen activation pathway in peripheral blood mononuclear cells in multiple sclerosis: possible pathomechanism of matrix metalloproteinase activation', Multiple Sclerosis Journal, 19 1268-1274 (2013) [C1]
2013Budden T, Bowden NA, 'The Role of Altered Nucleotide Excision Repair and UVB-Induced DNA Damage in Melanomagenesis', INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 14 1132-1151 (2013) [C1]
2013Bolton KA, Ross JP, Grice DM, Bowden NA, Holliday EG, Avery-Kiejda KA, Scott RJ, 'STaRRRT: a table of short tandem repeats in regulatory regions of the human genome', BMC GENOMICS, 14 (2013) [C1]
2012Cox MB, Ban M, Bowden NA, Baker A, Scott R, Lechner-Scott J, 'Potential association of vitamin D receptor polymorphism Taq1 with multiple sclerosis', Multiple Sclerosis Journal, 18 16-22 (2012) [C1]

Co-authors: RODNEY SCOTT

2012Young KMN, Scurry JP, Jaaback KS, Bowden NA, Scott R, 'Bilateral dysgerminoma associated with gonadoblastoma and sex-cord stromal tumour with annular tubules in a 28-year-old fertile woman with normal karyotype', Pathology, 44 257-260 (2012) [C3]

Co-authors: RODNEY SCOTT

2012Ashton KA, Scurry JP, Rutherford J, Otton GR, Scott R, Bowden NA, 'Nodular prurigo of the vulva', Pathology, 44 565-567 (2012) [C3]
2011Wong-Brown M, Nordfors C, Mossman D, Pecenpetelovska G, Kiejda KA, Talseth-Palmer B, et al., 'BRIP1, PALB2, and RAD51C mutation analysis reveals their relative importance as genetic susceptibility factors for breast cancer', Breast Cancer Research and Treatment, 127 853-859 (2011) [C1]
2011Kiejda KA, Bowden NA, Croft AJ, Scurr LL, Kairupan CF, Ashton KA, et al., 'P53 in human melanoma fails to regulate target genes associated with apoptosis and the cell cycle and may contribute to proliferation', BMC Cancer, 11 203-219 (2011) [C1]
2010Bowden NA, Ashton KA, Kiejda KA, Zhang XD, Hersey P, Scott R, 'Nucleotide excision repair gene expression after cisplatin treatment in melanoma', Cancer Research, 70 7918-7926 (2010) [C1]
2010Li J, Wang W, Baines KJ, Bowden NA, Hansbro PM, Gibson PG, et al., 'IL-27/IFN-y induce MyD88-dependent steroid-resistant airway hyperresponsiveness by inhibiting glucocorticoid signaling in macrophages', Journal of Immunology, 185 4401-4409 (2010) [C1]
2010Baines KJ, Simpson JL, Bowden NA, Scott R, Gibson PG, 'Differential gene expression and cytokine production from neutrophils in asthma phenotypes', European Respiratory Journal, 35 522-531 (2010) [C1]
2009Talseth-Palmer B, Bowden NA, Meldrum C, Nicholl J, Thompson E, Friend K, et al., 'A 1q44 deletion, paternal UPD of chromosome 2 and a deletion due to a complex translocation detected in children with abnormal phenotypes using new SNP array technology', Cytogenetic and Genome Research, 124 94-101 (2009) [C1]
2008Beveridge NJ, Tooney PA, Carroll AP, Gardiner EJ, Bowden NA, Scott R, et al., 'Dysregulation of miRNA 181b in the temporal cortex in schizophrenia', Human Molecular Genetics, 17 1156-1168 (2008) [C1]
2008Talseth-Palmer B, Bowden NA, Hill A, Meldrum C, Scott R, 'Whole genome amplification and its impact on CGH array profiles', BMC Research Notes, 1 108 (2008) [C1]
2008Bowden NA, Scott R, Tooney PA, 'Altered gene expression in the superior temporal gyrus in schizophrenia', BMC Genomics, 9 1-12 (2008) [C1]
2007Bowden NA, Croft A, Scott R, 'Gene expression profiling in familial adenomatous polyposis adenomas and desmoid disease', Hereditary Cancer in Clinical Practice, 5 79-96 (2007) [C1]
2007Bowden NA, Scott R, Tooney PA, 'Altered expression of regulator of G-protein signalling 4 (RGS4) mRNA in the superior temporal gyrus in schizophrenia', Schizophrenia Research, 89 165-168 (2007) [C1]
2006Bowden NA, Weidenhofer JC, Scott R, Schall U, Todd J, Michie PT, Tooney PA, 'Preliminary investigation of gene expression profiles in peripheral blood lymphocytes in schizophrenia', Schizophrenia Research, 82 175-183 (2006) [C1]
2006Bowden NA, Tooney PA, Scott R, 'Gene expression profiling of xeroderma pigmentosum', Hereditary Cancer in Clinical Practice, 4 103-110 (2006) [C1]
2006Weidenhofer JC, Bowden NA, Scott R, Tooney PA, 'Altered gene expression in the amygdala in schizophrenia: Up-regulation of genes located in the cytomatrix active zone', Molecular and Cellular Neuroscience, 31 243-250 (2006) [C1]
2006Weidenhofer J, Bowden NA, Scott RJ, Tooney PA, 'Dysfunction of genes regulating membrane exocytosis in schizophrenia', AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY, 40 A129-A129 (2006)
Show 27 more

Conference (60 outputs)

YearCitationAltmetricsLink
2014Bolton KA, Ross JP, Grice DM, Bowden NA, Holliday EG, Avery-Kiejda KA, Scott RJ, 'Short tandem repeats are variable genetic elements that may have major consequences for multiple disease.', ASMR Satellite Scientific Meeting Proceedings, Newcastle, NSW, Australia (2014)
2014Warren C, Ashton KA, Vilain RE, Braye SG, Moscato P, Bowden NA, 'The expression of the previously uncharacterised isoform, Bcl-2B is associated with increased survival in melanoma.', ASMR Satellite scientific meeting proceedings, Newcastle, NSW, Australia (2014)
2014Budden T, Bowden NA, 'Melanoma displays reduced nucleotide excision repair in response to UVB-induced DNA damage', ASMR Scientific Satellite Meeting Proceedings, Newcastle, NSW, Australia (2014)
2014Davey RJ, Vilain RE, Ashton KA, Braye SG, Scott RJ, Bowden NA, 'XPC expression is associated with BRAFV600E and NRASQ61R mutations and poor survival in melanoma.', ASMR Satellite scientific meeting proceedings, Newcastle, NSW, Australia (2014)
2014Bowden NA, 'How melanoma and melanocytes respond to UV-light and chemotherapy', Skin Cancer College of Australasia, Surfers Paradise, Qld, Australia (2014)
2014Murray HC, Maltby VE, Bowden NA, 'Nucleotide excision repair in response to UVA is deficient in melanoma.', Pigment Cell and Melanoma Research, Singapore (2014)
2014Budden T, Bowden NA, 'Melanoma exhibits defective nucleotide excision repair of UVB-induced DNA photoproducts', Pigment Cell and Melanoma Research, Singapore (2014)
2014Bowden NA, 'Investigation of the nucleotide excision repair pathway for melanoma biomarkers', Cure Cancer Australia symposium proceedings, Sydney, NSW, Australia (2014)
2014Murray HC, Maltby VE, Bowden NA, 'Nucleotide excision repair function in melanoma.', ASMR Satellite scientific meeting proceedings, Newcastle, NSW, Australia (2014)
2013Bolton KA, Avery-Kiejda KA, Grice DM, Holliday EG, Bowden NA, Ross J, Scott RJ, 'STaRRRT: Our new resource for identifying candidates of genetic risk in breast and endometrial cancer.', Translational Cancer Research Conference Abstract booklet, Newcastle, Australia (2013) [E3]
2013Wong-Brown M, Avery-Kiejda K, Bowden N, Scott R, 'Prevalence of BRCA1 and BRCA2 germline mutations in triple-negative breast cancer', Programme, Newcastle (2013) [E3]
2013Wong-Brown M, Li S, Wilkins M, Avery-Kiejda KA, Bowden N, Scott R, 'Targeted resequencing of BRCA1 and BRCA2 in familial breast cancer.', Kathleen Cunningham Foundation Consortium for Research into Familial Aspects of Cancer 2013 Research and Practice Proceedings, Cairns, QLD, Australia. (2013) [E3]
2013Bolton KA, Ross J, Grice DM, Avery-Kiejda KA, Bowden NA, Holliday EG, Scott RJ, 'Role of Short Tandem Repeats in Disease and Evolutionary Mechanisms.', 34th Lorne Genome Conference Proceedings, Lorne, VIC, Australia (2013) [E3]
2013Warren C, Ashton KA, Vilain RE, Braye SG, Moscato P, Bowden NA, 'Expression of the alternatively spliced variants of Bcl-2 in melanoma', HMRI Translational Cancer Research Conference, Newcastle, NSW, Australia (2013)
2013Budden T, Scott RJ, Bowden NA, 'Possible Role for Nucleotide Excision Repair and UVB-induced DNA damage in Melanoma Development', Pigment Cell and Melanoma Research, Philadelphia, USA (2013)
2013Davey RJ, Ashton KA, Vilain RE, Braye SG, Scott RJ, Bowden NA, 'Nucleotide excision repair: biomarkers of UV-radiation and disease progression in melanoma.', HMRI Translational Cancer Research Conference, Newcastle, NSW, Australia (2013)
2013Murray HC, Maltby VE, Bowden NA, 'Nucleotide Excision Repair of UVA-Induced DNA Damage: Function in Sunlight-Induced Melanoma.', Pigment Cell and Melanoma Research, Philadelphia, USA (2013)
2013Warren C, Ashton KA, Vilain RE, Braye SG, Moscato P, Bowden NA, 'Expression of the uncharacterised Bcl-2 isoform, Bcl-2ß, in melanoma.', Pigment Cell and Melanoma Research, Philadelphia, USA (2013)
2013Ashton KA, Vilain RE, Braye SG, Scott RJ, Bowden NA, 'Investigation of clinical parameters and altered transcriptome expression associated with UV radiation in melanoma.', Pigment Cell and Melanoma Research, Philadelphia, USA (2013)
2013Davey RJ, Ashton KA, Vilain RE, Braye SG, Scott RJ, Bowden NA, 'Investigation of the nucleotide excision repair pathway for biomarkers of UV-radiation and disease progression in melanoma.', Pigment Cell and Melanoma Research, Philadelphia, USA (2013)
2013Murray HC, Maltby VE, Bowden NA, 'Deficient expression of global genome nucleotide excision repair genes in melanoma cells following UVA irradiation.', HMRI Translational Cancer Research Conference, Newcastle, NSW, Australia (2013)
2013Ashton KA, Davey RJ, Vilain RE, Braye SG, Scott RJ, Bowden NA, 'Investigation of UV radiation, clinical data and the transcriptome of diagnostic melanoma tissue.', HMRI Translational Cancer Research Conference, Newcastle, NSW, Australia (2013)
2013Budden T, Scott RJ, Bowden NA, 'Altered nucleotide excision repair in melanoma in response to UVB-induced DNA damage.', HMRI Translational Cancer Research Conference, Newcastle, NSW, Australia (2013)
2012Wong-Brown M, Li S, Wilkins M, Kiejda KA, Bowden NA, Scott R, 'Exploratory targeted resequencing of BRCA1 and BRCA2 in inherited breast cancer', Programme. kConFab Familial Aspects of Cancer: Research & Practice 2012, Kingscliff, NSW (2012) [E3]
2012Wong-Brown M, Li S, Wilkins M, Kiejda KA, Bowden NA, Scott R, 'Targeted resequencing of BRCA1 and BRCA2 in inherited breast cancer', Cancer Research, San Antonio, Texas (2012) [E3]
2012Bolton KA, Ross J, Grice DM, Kiejda KA, Bowden NA, Holliday EG, Scott R, 'Potential role of short tandem repeats in disease processes', Abstracts. 6th Australian Health & Medical Research Congress, Adelaide, SA (2012) [E3]
2012Bowden NA, Ashton K, Vilian R, Braye S, Scott R, 'DNA repair transcripts: biomarkers of sun exposure and tumour aggression in melanoma', Abstract book, Sydney (2012) [E3]
2012Bowden NA, Ashton KA, Vilain RE, Braye SG, Avery-Kiejda KA, Zhang XD, et al., 'Regulators of DNA repair do not respond to DNA damaging therapy but correlate with survival in melanoma.', Biomarker Discovery Conference Proceedings, Shoal Bay, NSW, Australia (2012)
2012Wong M, Avery-Kiejda KA, Bowden NA, Scott RJ, 'Targeted resequencing of BRCA1 and BRCA2 in inherited breast cancer', Human Genome Meeting, Sydney, NSW, Australia (2012)
2012Bowden NA, 'Utilisation of personal CNV for diagnosis and treatment of cancer - A discussion of 2 cases in a clinical setting', Biomarker Discovery Conference Proceedings, Shoal Bay, NSW, Australia (2012)
2011Foster P, Li J, Wang W, Baines K, Bowden N, Hansbro P, et al., 'IL-27 underpins steroid resistant airway hyperresponsiveness via MyD88 dependent pathways', ALLERGY, Istanbul, TURKEY (2011) [E3]
2011Johansson P, Wei JS, Chen Q, Bowden NA, Badgett TC, Song YK, et al., 'A genomic portrait of tumor progression using next-generation sequencing', American Association for Cancer Research (AACR) 102nd Annual Meeting. Innovation and Collaboration: The Path to Progress Proceedings, Orlando, FL (2011) [E3]
2011Bowden NA, Ashton KA, Kiejda KA, Zhang XD, Hersey P, Scott R, 'Downstream effects of reduction in nucleotide excision repair in response to cisplatin treatment in melanoma', Pigment Cell & Melanoma Research, Tampa, FL (2011) [E3]
2010Ashton KA, Bowden NA, Vilain RE, Kairupan CF, Kiejda KA, Zhang XD, et al., 'Genetic variation of the base excision repair gene, MUTYH, and melanoma development', Melanoma 2010 Congress. Oral and Poster Abstracts, Sydney, NSW (2010) [E3]
2010Bowden NA, Ashton KA, Kiejda KA, Vilain RE, Braye SG, Kairupan CF, et al., 'Nucleotide excision repair gene expression in melanoma', Melanoma 2010 Congress. Oral and Poster Abstracts, Sydney, NSW (2010) [E3]
2010Vilain RE, Ashton KA, Bowden NA, Braye SG, Ashman LK, Scott RJ, 'Clinicopathological and gene expression profiling of advanced melanoma harbouring KIT and common kinase mutations', Melanoma 2010 Congress. Oral and Poster Abstracts, Sydney, NSW (2010) [E3]
2010Ashton KA, Bowden NA, Kairupan CF, Kiejda KA, Zhang XD, Hersey P, Scott R, 'Base excision repair and gene expression profiling in malignant melanoma', Sydney Cancer Conference 2010. Profiling Risk, Personalising Treatment and Predicting Outcomes. Conference Program and Abstract Book, Sydney, NSW (2010) [E3]
2010Wong-Brown M, Bowden NA, Kiejda KA, Scott R, 'BRIP1 and PALB2 mutation detection in Hunter-New England familial breast cancer cohort', 27th HUGO-IABCR Congress 2010. Genomics, Biology and Breast Cancer Treatment. Programme & Abstract Book, Biopolis, Singapore (2010) [E3]
2010Croft AJ, Kiejda KA, Bowden NA, Zhang X, Scott R, Hersey P, 'Expression profiling on apoptosis-related genes in cisplatin-treated human melanoma cell lines', 22nd Lorne Cancer Conference: Abstracts and Delegate Information, Lorne, Vic. (2010) [E3]
2010Bowden NA, Ashton KA, Kiejda KA, Zhang XD, Hersey P, Scott R, 'Altered nucleotide excision repair gene expression after cisplatin treatment in melanoma', AACR 101st Annual Meeting 2010. Abstracts, Washington, DC (2010) [E3]
2010Wong-Brown M, Bowden NA, Forbes JF, Braye SG, Scott R, 'Microsatellite instability (I) in breast tumours', Sydney Cancer Conference 2010. Profiling Risk, Personalising Treatment and Predicting Outcomes. Conference Program and Abstract Book, Sydney, NSW (2010) [E3]
2009Bowden NA, Ashton KA, Stibbard GJ, Cox MB, Baines KJ, Scott R, 'Predicting xeroderma pigmentosum complementation group by gene expression profiling', AMATA 2009, Katoomba, NSW (2009) [E3]
2009Cox MB, Bowden NA, Scott R, Lechner-Scott J, 'Gene expression profiling in multiple sclerosis', AMATA 2009, Katoomba, NSW (2009) [E3]

Co-authors: RODNEY SCOTT

2009Evans T-J, Bowden NA, Talseth-Palmer B, Catchpoole D, Scott R, 'Copy number variation in childhood acute lmphoblastic leukaemia', AMATA 2009, Katoomba, NSW (2009) [E3]
2009Kairupan CF, Bowden NA, Ashton KA, Zhang XD, Hersey P, Scott R, 'Gene expression profiling in malignant melanoma', AMATA 2009, Katoomba, NSW (2009) [E3]
2009Kiejda KA, Scurr LL, Wade MA, Jiang CC, Weir AJW, Bowden NA, et al., 'Cisplatin induces apoptosis independently of Noxa or PUMA in human melanoma cells', 21st Lorne Cancer Conference, Lorne, VIC (2009) [E3]
2008Bowden NA, Ashton KA, Kiejda KA, Zhang XD, Hersey P, Scott R, 'Altered nucleotide excision repair gene expression after cisplatin treatment in melanoma', Proceedings of the Australian Health and Medical Research Congress 2008, Brisbane, QLD (2008) [E3]
2008Bowden NA, Ashton KA, Baines KJ, Cox MB, Scott R, 'Altered gene expression after UV-light induced DNA damage', Conference on Translational Cancer Research: Abstracts, Newcastle, NSW (2008) [E3]
2008Bowden NA, Baines KJ, Cox MB, Scott R, 'Response to uv-light exposure in fibroblasts with differential nucleotide excision repair capacity', ASMR XVII NSW Scientific Meeting: Programme and Abstracts, Sydney, NSW (2008) [E3]
2008Bowden NA, Baines KJ, Cox MB, Scott R, 'Altered gene expression in nucleotide excision repair deficient fibroblasts after UV-light exposure', AACR Meeting Abstracts, San Diego, CA (2008) [E3]
2007Tooney PA, Scott R, Cairns MJ, Bowden NA, 'Altered gene expression in the superior temporial gyrus in schizophrenia', Schizophrenia Bulletin (Abstracts of the 11th International Congress on Schizophrenia Research), Colorado Springs, Colorado (2007) [E3]
2007Cox M, Bowden NA, Moscato PA, Berretta RE, Scott R, 'Memetic algorithms as a new method to interpret gene expression profiles in multiple sclerosis', Multiple Sclerosis (Abstracts of the 23rd Congress of the European Committee for Treatment and Research in Multiple Sclerosis and the 12th Annual Conference of Rehabilitation in Multiple Sclerosis), Prague, Czech Republic (2007) [E3]
2007Baines KJ, Bowden NA, Scott R, Simpson JL, Gibson PG, 'Molecular analysis of neutrophils in asthma subtypes', Respirology (TSANZ Abstracts-Posters), Auckland (2007) [E3]
2006Weidenhofer JC, Bowden NA, Scott R, Tooney PA, 'Dysfunction of genes regulating membrane exocytosis in schizophrenia (Poster presentation)', Australian and New Zealand Journal of Psychiatry (Vol 40, noS2), Fremantle, Western Australia (2006) [E3]
2005Bowden NA, Weidenhofer JC, Scott R, Schall UA, Todd J, Michie PT, Tooney PA, 'Classification of schizophrenia using differential gene expression in peripheral blood lymphocytes', Human Genetics Society of Australasia, Newcastle (2005) [E3]
2004Weidenhofer JC, Bowden NA, Scott R, Tooney PA, 'Gene Profiling in the Amygdala in Schizophrenia', American Journal of Medical Genetics, Ireland (2004) [E3]
2004Weidenhofer JC, Bowden NA, Scott R, Tooney PA, 'Altered Gene Expression Profiles in the Amygdala in Schizophrenia', Proceedings of the Australian Neuroscience Society, Melbourne (2004) [E3]
2004Bowden NA, Weidenhofer JC, Scott R, Todd J, Case V, Schall UA, Tooney PA, 'Altered Expression of Brain Related Genes in Lymphocytes in Schizophrenia', American Journal of Medical Genetics, Ireland (2004) [E3]
2004Bowden NA, Weidenhofer JC, Scott R, Todd J, Case V, Schall UA, Tooney PA, 'Differental Gene Expression in Peripheral Blood Lymphocytes in Schizophrenia', Proceedings of the Australian Neuroscience Society, Melbourne (2004) [E3]
2004Bowden NA, Weidenhofer JC, Scott R, Todd J, Case V, Schall UA, Tooney PA, 'Distinct Gene Expression Profiles due to Age in Schizophrenia', Proceedings of the Australian Neuroscience Society, Melbourne (2004) [E3]
Show 57 more
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Grants and Funding

Summary

Number of grants22
Total funding$1,889,821

- Indicates that the researcher may be seeking students for this project.

Click on a grant title below to expand the full details for that specific grant.

2015 (2 grants)

Investigation of the DNA repair protein XPC in melanoma treatment resistance.$600,000
Funding Body: Cancer Institute NSW

Project Team
Doctor Nikola Bowden
SchemeRole
Career Development FellowshipChief Investigator
Total AmountFunding StartFunding Finish
$600,00020152017
GNo:G1400706

Destroying kidney cells that evade current treatments$51,630
Funding Body: Kidney Health Australia

Project Team
Doctor Craig Gedye, Doctor Nikola Bowden, Professor Rodney Scott
SchemeRole
Medical Research Project GrantsInvestigator
Total AmountFunding StartFunding Finish
$51,63020152015
GNo:G1401048

2013 (2 grants)

Investigation of the nucleotide excision repair pathway for melanoma biomarkers. $199,782
Funding Body: Cancer Australia

Project Team
Doctor Nikola Bowden
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$199,78220132015
GNo:G1200391

Development of a chemotherapy response/resistance test for ovarian cancer$92,088
Funding Body: Hunter Medical Research Institute

Project Team
Doctor Nikola Bowden
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$92,08820132014
GNo:G1300897

2012 (5 grants)

Research Equipment$54,355
Funding Body: Hunter Melanoma Foundation

Project Team
Doctor Nikola Bowden
SchemeRole
Research Equipment Grant Chief Investigator
Total AmountFunding StartFunding Finish
$54,35520122013
GNo:G1200936

Development of a diagnostic genetic test for childhood skin cancer disorders$40,000
Funding Body: Hunter Medical Research Institute

Project Team
Doctor Nikola Bowden, Professor Rodney Scott
SchemeRole
Research GrantChief Investigator
Total AmountFunding StartFunding Finish
$40,00020122012
GNo:G1200164

Development of a diagnostic test for Xeroderma Pigmentosum , Cockayne’s Syndrome and Trichothiodystrophy$17,500
Funding Body: The Marian & E. H. Flack Trust

Project Team
Doctor Nikola Bowden
SchemeRole
Research GrantChief Investigator
Total AmountFunding StartFunding Finish
$17,50020122012
GNo:G1300524

Emerging Research Leaders Program 2011$15,000
Funding Body: University of Newcastle

Project Team
Doctor Nikola Bowden
SchemeRole
Emerging Research Leaders ProgramChief Investigator
Total AmountFunding StartFunding Finish
$15,00020122012
GNo:G1101040

Rotary Club of Cardiff Melanoma Scholar Award$7,000
Funding Body: Hunter Medical Research Institute

Project Team
Doctor Nikola Bowden
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$7,00020122013
GNo:G1200831

2011 (1 grants)

Nucleotide excision repair gene expression in melanoma$35,000
Funding Body: Hunter Medical Research Institute

Project Team
Doctor Nikola Bowden, Doctor Katie Ashton, Doctor Stephen Braye, Professor Rodney Scott, Dr Ricardo Vilain
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$35,00020112011
GNo:G1001057

2010 (2 grants)

Altered nucleotide excision repair in melanoma in response to cisplatin and UV-light irradiation$90,000
Funding Body: Cancer Australia

Project Team
Doctor Nikola Bowden
SchemeRole
Priority-driven Collaborative Cancer Research SchemeChief Investigator
Total AmountFunding StartFunding Finish
$90,00020102010
GNo:G0190317

101st American Association of Cancer Research Annual Meeting, Convention Centre, Washington DC, USA, 17 - 21st April 2010$1,975
Funding Body: University of Newcastle - Faculty of Health and Medicine

Project Team
Doctor Nikola Bowden
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$1,97520102010
GNo:G1000132

2009 (3 grants)

Molecular mechanisms of UV-light induced skin malignancies$333,921
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Doctor Nikola Bowden
SchemeRole
Early Career FellowshipsChief Investigator
Total AmountFunding StartFunding Finish
$333,92120092014
GNo:G0189304

Genome wide SNP associated study of childhood acute lymphoblastic leukaemia$140,000
Funding Body: Hunter Medical Research Institute

Project Team
Professor Rodney Scott, Doctor Nikola Bowden, Doctor Bente Talseth-Palmer
SchemeRole
Paediatric Oncology Project GrantInvestigator
Total AmountFunding StartFunding Finish
$140,00020092010
GNo:G0189790

Gene expression profiling of Xeroderma pigmentosum$45,000
Funding Body: Hunter Medical Research Institute

Project Team
Professor Rodney Scott, Doctor Nikola Bowden, Doctor Katie Ashton
SchemeRole
Postdoctoral FellowshipInvestigator
Total AmountFunding StartFunding Finish
$45,00020092010
GNo:G0900194

2008 (3 grants)

Gene expression profiling of xeroderma pigmentosum$100,000
Funding Body: Hunter Medical Research Institute

Project Team
Professor Rodney Scott, Doctor Nikola Bowden
SchemeRole
Postdoctoral FellowshipInvestigator
Total AmountFunding StartFunding Finish
$100,00020082008
GNo:G0188353

Genome wide SNP association study of childhood acute lymphoblastic leukaemia$20,000
Funding Body: Hunter Children`s Research Foundation

Project Team
Doctor Nikola Bowden, Professor Rodney Scott, Doctor Bente Talseth-Palmer
SchemeRole
Paediatric Oncology Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$20,00020082008
GNo:G0188483

Australian health & meidcal Research Congress, Brisbane Convention Centre, 16/11/2008 - 21/11/2008$1,730
Funding Body: University of Newcastle

Project Team
Doctor Nikola Bowden
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$1,73020082008
GNo:G0189663

2007 (3 grants)

Gene expression profiling of xeroderma pigmentosum$20,000
Funding Body: Hunter Medical Research Institute

Project Team
Doctor Nikola Bowden, Professor Rodney Scott
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$20,00020072007
GNo:G0187261

Identification of a predictive approach to assigning to undefined xeroderma pigmentosum patients to subgroups using gene expression profiling$10,000
Funding Body: Hunter Medical Research Institute

Project Team
Doctor Nikola Bowden
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$10,00020072007
GNo:G0187256

Travel prize to attend: 4th Annual Illumina User Meeting (March '08) and American Association for Cancer Research (AACR) 99th Annual Meeting (April 12-16 '08)$3,000
Funding Body: Hunter Medical Research Institute

Project Team
Doctor Nikola Bowden
SchemeRole
PULSE Education PrizeChief Investigator
Total AmountFunding StartFunding Finish
$3,00020072007
GNo:G0187298

2006 (1 grants)

Gene Expression Profiling of Xeroderma Pigmentosum$11,840
Funding Body: University of Newcastle

Project Team
Doctor Nikola Bowden
SchemeRole
Early Career Researcher GrantChief Investigator
Total AmountFunding StartFunding Finish
$11,84020062006
GNo:G0186964
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Research Supervision

Number of current supervisions5
Total current UoN PhD EFTSL2.95

For supervisions undertaken at an institution other that the University of Newcastle, the institution name is listed below the program name.

Current Supervision

CommencedProposed
Completion
ProgramSupervisor TypeResearch Title
20132017PhD (Medical Genetics)Principal SupervisorExpression of the Uncharacterised BCL-2 Isoform, BCL2-B in Melanoma
20132017PhD (Medical Genetics)Principal SupervisorNucleotide Excision Repair of UVA-Induced DNA Damage: Regulation in Sunlight-Induced Melanoma
20132017PhD (Medical Genetics)Principal SupervisorNucleotide Excision Repair and UVB-Induced DNA Damage in Melanoma Development
20122016PhD (Medical Genetics)Principal SupervisorExamining Nucleotide Excision Repair Genes in Melanoma
20102016PhD (Medical Genetics)Co-SupervisorRole of Tandem Repeats in Genetic Susceptibility to Breast Cancer

Past Supervision

YearProgramSupervisor TypeResearch Title
2014PhD (Medical Genetics)Co-SupervisorThe Contribution of Genetic Susceptibility to Breast Cancer
2013PhD (Medical Genetics)Co-SupervisorThe Complex Genetics of Multiple Sclerosis
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Dr Nikola Bowden

Work Phone(02) 40420277
Fax02 40420031
Email
PositionResearch Fellow
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine
The University of Newcastle, Australia
Focus AreaMedical Genetics
Office
HMRI Level 3 West,
HMRI,
HMRI
URL:www.newcastle.edu.au/profile/nikola-bowden