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Dr Nicole Ryan

Postdoctoral Research Fellow

School of Medicine and Public Health (Public Health)

Career Summary

Biography

The combination of an industrial science/engineering background and research higher degree studies within health science (medicine) has provided me with a good understanding into the practical applications and importance of investigation and objective testing for evidence based medicine. My current position is as an NHMRC Early Career Research Fellow in the Clinical Toxicology Research Group within the School of Medicine and Public Health. I co-ordinate and conduct randomised controlled trials into snake and spider envenoming as well as observational studies into the epidemiology and characterisation of medication toxicity. I am particularly interested in neuropathic disorders and neuropathic medication profiling.

My previous research role was based in Respiratory Medicine investigating the causes and mechanisms involved in refractory chronic cough. I  developed objective cough testing at the HMRI research facility and in the department of respiratory medicine at John Hunter Hospital. I like to approach my research from a clinical perspective when feasible by being actively involved in the testing and collection of data from research participants. Analysing the subsequent data is always interesting and the translation of findings into practical application.

Research Expertise
I have recently (early 2014) had a change in my research focus by commencing a post-doctoral research fellow position with the Clinical Toxicology Research Group located at the Calvary Mater Newcastle hospital site. Here I continue to develop my interest in the assessment of the efficacy and safety of drug therapy. During my PhD I completed a randomised controlled trial looking at the effectiveness and adverse effects of gabapentin medication in the treatment of chronic cough. The snake and spider studies that I now investigate have provided me with the opportunity to conduct three more RCTs testing the effects of medications. My prior research focus was in the identification and treatment of patients with refractory and idiopathic chronic cough. Ten years of research in this area led to the significant finding that laryngeal hypersensitivity is common in refractory chronic cough patients and that this can be successfully treated with neuropathic medications such as gabapentin or by behavioural techniques such as speech pathology and cough suppression techniques.

Teaching Expertise
Current co-supervisor of two PhD students. One of which is investigating myotoxicity and the early use of antivenom in Australia and Sri Lanka while my second student's PhD focuses on antidotes. Brief teaching role at Newcastle TAFE to 3rd and 4th year Applied Science (Chemistry) students before my move into medical research.


Qualifications

  • PhD (Medicine), University of Newcastle
  • Bachelor of Science, University of Newcastle

Keywords

  • Evidence based medicine
  • Science based
  • Snake Envenoming
  • Spider Envenoming
  • TAFE (Chemistry)
  • Toxicology

Fields of Research

CodeDescriptionPercentage
111502Clinical Pharmacology and Therapeutics40
111506Toxicology (incl. Clinical Toxicology)60

Professional Experience

UON Appointment

DatesTitleOrganisation / Department
16/01/2015 - 30/04/2018Postdoctoral Research FellowUniversity of Newcastle
School of Medicine and Public Health
Australia
7/02/2014 - 21/02/2014Postdoctoral Reseach FellowUniversity of Newcastle
School of Medicine and Public Health
Australia
2/05/2011 - 26/08/2011Research OfficerUniversity of Newcastle
School of Medicine and Public Health
Australia

Academic appointment

DatesTitleOrganisation / Department
1/05/2014 - NHMRC Early Career Research Fellow
NHMRC - Early Career Fellowships (Formerly Postdoctoral Training Fellowships)
University of Newcastle
Clinical Toxicology Research Group
Australia
1/10/2010 - 1/06/2013Research OfficerUniversity of Newcastle
School of Medicine and Public Health
Australia
1/12/2005 - 1/10/2010Research PhD CandidateUniversity of Newcastle
School of Medicine and Public Health
Australia

Membership

DatesTitleOrganisation / Department
1/01/2014 - 30/06/2016Membership - ASMR
Australian Society for Medical Research Committee Member, 2015 Satellite Scientific Meeting Convenor.
Australian Society for Medical Research (ASMR)
Australia

Awards

Research Award

YearAward
2012HMRI Early Career Travel Award
Unknown
2012Faculty of Health Research Higher Degree Excellence Award
Unknown
2011HMRI Pulse Education Prize
Unknown
2008Finalist 10 of the Best Research Showcase
Unknown

Invitations

Speaker

YearTitle / Rationale
2012Gabapentin for refractory chronic cough: A randomised controlled trial
Organisation: Thoracic Society of Australia and New Zealand Description: CICADA Cough Symposium Invited Speaker
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Journal article (14 outputs)

YearCitationAltmetricsLink
2015Ryan NM, Isbister GK, 'Tramadol overdose causes seizures and respiratory depression but serotonin toxicity appears unlikely.', Clin Toxicol (Phila), 53 545-550 (2015)
DOI10.3109/15563650.2015.1036279Author URL
Co-authorsGeoff Isbister
2014Simpson JL, Baines KJ, Ryan N, Gibson PG, 'Neutrophilic asthma is characterised by increased rhinosinusitis with sleep disturbance and GERD', Asian Pacific Journal of Allergy and Immunology, 32 66-74 (2014) [C1]

Background: Asthma is a heterogeneous inflammatory disease and eosinophilic, noneosinophilic and neutrophilic forms are recognised. While clinically similar to eosinophilic asthma, patients with non-eosinophilic asthma have different responses to treatment and little is known about the triggers of symptoms and inflammation. Objective: This study sought to characterise asthma control, exacerbation frequency and potential triggers of non-eosinophilic and specifically neutrophilic asthma such as infection, gastroesophageal reflux disease, and rhinosinusitis. Methods: Adults with asthma (n=65; doctor's diagnosis plus demonstrated response to bronchodilator and/or airways hyperresponsiveness to hypertonic saline) were recruited from the Respiratory and Sleep Medicine Ambulatory Care Service at John Hunter Hospital, NSW, Australia. Questionnaires were administered to assess gastroesophageal reflux disease, rhinosinusitis and asthma control. A sputum induction was performed and sputum was processed for assessment of inflammatory cells, infection, and lipid laden macrophages (Oil Red O). Results: Participants with neutrophilic asthma (n=11, 23%) had a higher frequency of primary care doctor visits for asthma exacerbations and a high prevalence (>70%) of chest infections in the previous 12 months. There was also an increased prevalence of rhinosinusitis (64%) and increased symptoms of gastroesophageal reflux disease compared to those with eosinophilic asthma. Conclusions: The clinical pattern of neutrophilic asthma is different from paucigranulocytic and eosinophilic asthma with evidence of abnormal upper airways responses. Specific and targeted treatment of these airway problems may assist in the control and management of neutrophilic asthma.

DOI10.12932/AP0322.32.1.2014
CitationsScopus - 1
Co-authorsJodie Simpson, Katherine Baines, Peter Gibson
2014Gibson PG, Simpson JL, Ryan NM, Vertigan AE, 'Mechanisms of cough', CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 14 55-61 (2014) [C1]
DOI10.1097/ACI.0000000000000027Author URL
CitationsScopus - 3Web of Science - 3
Co-authorsPeter Gibson, Jodie Simpson
2014Ryan NM, 'A review on the efficacy and safety of gabapentin in the treatment of chronic cough.', Expert Opinion on Pharmacotherapy, 16 1-11 (2014) [C1]
DOI10.1517/14656566.2015.981524
CitationsScopus - 2Web of Science - 2
2014Ryan NM, Gibson PG, 'Recent additions in the treatment of cough', JOURNAL OF THORACIC DISEASE, 6 S739-S747 (2014) [C1]
DOI10.3978/j.issn.2072-1439.2014.03.13Author URL
CitationsWeb of Science - 1
Co-authorsPeter Gibson
2014Ryan NM, Birring SS, Gibson PG, 'Arnold¿s nerve cough reflex: evidence for chronic cough as a sensory vagal neuropathy', Journal of Thoracic Disease, 6 S748-S752 (2014) [C3]
DOI10.3978/j.issn.2072-1439.2014.04.22
Co-authorsPeter Gibson
2013Ryan NM, Birring SS, Gibson PG, 'Gabapentin for refractory chronic cough Reply', LANCET, 381 624-625 (2013) [C3]
Author URL
CitationsScopus - 2Web of Science - 2
Co-authorsPeter Gibson
2012Ryan NM, Birring SS, Gibson PG, 'Gabapentin for refractory chronic cough: a randomised, double-blind, placebo-controlled trial', The Lancet, 380 1583-1589 (2012) [C1]
CitationsScopus - 55Web of Science - 50
Co-authorsPeter Gibson
2012Ryan NM, Vertigan AE, Ferguson JK, Wark PA, Gibson PG, 'Clinical and physiological features of postinfectious chronic cough associated with H1N1 infection', Respiratory Medicine, 106 138-144 (2012) [C1]
DOI10.1016/j.rmed.2011.10.007
CitationsScopus - 4Web of Science - 4
Co-authorsPeter Gibson, John Ferguson, Peter Wark
2011Gibson PG, Ryan NM, 'Cough pharmacotherapy: Current and future status', Expert Opinion on Pharmacotherapy, 12 1745-1755 (2011) [C1]
CitationsScopus - 12Web of Science - 10
Co-authorsPeter Gibson
2010Ryan NM, Vertigan AE, Bone S, Gibson PG, 'Cough reflex sensitivity improves with speech language pathology management of refractory chronic cough', Cough, 6 1-8 (2010) [C1]
CitationsScopus - 19
Co-authorsPeter Gibson
2009Ryan NM, Vertigan AE, Gibson PG, 'Chronic cough and laryngeal dysfunction improve with specific treatment of cough and paradoxical vocal fold movement', Cough, 5 1-8 (2009) [C1]
DOI10.1186/1745-9974-5-4
CitationsScopus - 9
Co-authorsPeter Gibson
2009Ryan NM, Gibson PG, 'Characterization of laryngeal dysfunction in chronic persistent cough', Laryngoscope, 119 640-645 (2009) [C1]
DOI10.1002/lary.20114
CitationsScopus - 11Web of Science - 11
Co-authorsPeter Gibson
2008Ryan NM, Gibson PG, 'Extrathoracic airway hyperresponsiveness as a mechanism of post infectious cough: Case report', Cough, 4 1-4 (2008) [C3]
DOI10.1186/1745-9974-4-7
CitationsScopus - 7
Co-authorsPeter Gibson
Show 11 more journal articles

Conference (8 outputs)

YearCitationAltmetricsLink
2014Ryan NM, Isbister GK, 'Tramadol overdose is associated with an increased risk of seizure and unassociated with serotonin toxicity', TAPNA Conference Program, Newcastle, NSW (2014) [E3]
Co-authorsGeoff Isbister
2014Ryan NM, Brown SSGA, Isbister GK, 'Serum sickness after the administration of Australian snake antivenoms', CLINICAL TOXICOLOGY (2014) [E3]
Author URL
Co-authorsGeoff Isbister
2013Ryan NM, 'Recent additions in the treatment of cough', J Thorac Dis, Guangzhou (2013) [E3]
2013Ryan NM, Vertigan AE, Bone SL, Gibson PG, 'Pregabalin and Speech Pathology for Chronic Cough', Journal of Thorac Disease, Guangzhou (2013) [E3]
2013Simpson JL, Baines KJ, Ryan NM, Gibson PG, 'NEUTROPHILIC ASTHMA IS CHARACTERIZED BY INCREASED GERD AND RHINOSINUSITIS WITH SLEEP DISTURBANCE', RESPIROLOGY (2013) [E3]
Author URL
Co-authorsKatherine Baines, Peter Gibson, Jodie Simpson
2012Ryan NM, Gibson PG, 'Gabapentin for idiopathic chronic cough: A randomised controlled trial', Lung, New York, NY (2012) [E3]
Co-authorsPeter Gibson
2011Ryan NM, Vertigan AE, Ferguson JK, Wark PA, Gibson PG, 'Investigation and characterization of persistent cough associated with H1N1 2009 influenza', Respirology, Perth, WA (2011) [E3]
Co-authorsPeter Gibson, Peter Wark, John Ferguson
2010Ryan NM, Vertigan AE, Bone S, Gibson PG, 'Cough reflex sensitivity improves with speech language pathology management of refractory chronic cough', Respirology, Brisbane, QLD (2010) [E3]
DOI10.1186/1745-9974-6-5
Co-authorsPeter Gibson
Show 5 more conferences
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Grants and Funding

Summary

Number of grants5
Total funding$205,628

Click on a grant title below to expand the full details for that specific grant.


20141 grants / $152,300

Combined Treatment for Chronic Cough$152,300

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamDoctor Nicole Ryan
SchemeEarly Career Fellowships
RoleLead
Funding Start2014
Funding Finish2014
GNoG1300679
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

20132 grants / $29,810

Pregabalin and Speech Pathology Treatment for Refractory Chronic Cough with Laryngeal Hypersensitivity $23,810

Funding body: John Hunter Hospital Charitable Trust Fund

Funding bodyJohn Hunter Hospital Charitable Trust Fund
Project TeamDoctor Nicole Ryan, Doctor Anne Vertigan, Doctor Michael Hayes, Ms Sarah Bone
SchemeResearch Grant
RoleLead
Funding Start2013
Funding Finish2013
GNoG1300784
Type Of FundingOther Public Sector - State
Category2OPS
UONY

HMRI Early Career Travel Award 2012$6,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Nicole Ryan
SchemeResearch Grant
RoleLead
Funding Start2013
Funding Finish2013
GNoG1300514
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

20121 grants / $4,000

PULSE Education Prize$4,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Nicole Ryan
SchemePULSE Education Prize
RoleLead
Funding Start2012
Funding Finish2012
GNoG1200455
Type Of FundingScheme excluded from IGS
CategoryEXCL
UONY

20071 grants / $19,518

Mrs Nicole M Ryan$19,518

Funding body: CCRE in Respiratory and Sleep Medicine

Funding bodyCCRE in Respiratory and Sleep Medicine
Project Team
SchemePostgraduate Research Scholarship
RoleInvestigator
Funding Start2007
Funding Finish2007
GNo
Type Of FundingInternal
CategoryINTE
UONY
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Research Supervision

Current Supervision

CommencedResearch Title / Program / Supervisor Type
2015Snake Envenoming in Australia and Beyond: Investigating Myotoxicity and the Early use of Antivenom
Pharmacology, Faculty of Health and Medicine
Co-Supervisor
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Dr Nicole Ryan

Position

Postdoctoral Research Fellow
Clinical Toxicology & Pharmacology
School of Medicine and Public Health
Faculty of Health and Medicine

Focus area

Public Health

Contact Details

Emailnicole.ryan@newcastle.edu.au
Phone(02) 4921 1312
Fax(02) 4921 1870

Office

Room5.46A, Level 5 New Med Building
BuildingCalvary Mater Newcastle
LocationCalvary Mater Newcastle Hospital

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