Staff Profile

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Career Summary

Biography

The combination of an industrial science/engineering background and research higher degree studies within health science (medicine) has provided me with a good understanding into the practical applications and importance of investigation and objective testing for evidence based medicine. My current position is as an NHMRC Early Careeer Research Fellow in the Department of Clinical Toxicology and Pharmacology at the Calvary Mater Newcastle Hospital site. I co-ordinate and conduct randomised controlled trials into  snake envenoming and associated antivenom/placebo-controlled trials, medication overdose pharmacology and characterisation of medication toxicity. I am particularlly interested in neuropathic disorders and neuropathic medication profiling.

My previous research role was based in Respiratory Medicine investigating the causes and mechanisms involved in refractory chronic cough. I  developed objective cough testing at the HMRI research facility and in the department of respiratory medicine at John Hunter Hospital. I like to approach my research from a clinical perspective when feasible by being actively involved in the testing and collection of data from research participants. Analysing the subsequent data is always interesting and the translation of findings into practical application.

Qualifications

  • PhD (Medicine), University of Newcastle, 05/08/2011
  • Bachelor of Science, University of Newcastle, 20/09/1996

Research

Research keywords

  • Science based

Research expertise

I have recently (early 2014) had a change in my research focus by commencing a post-doctoral research fellow position with the Clinical Toxicology & Pharmacology research group located at the Calvary Mater Newcastle Hospital site. Here I continue to develop my interest in the assessment of the efficacy and safety of drug therapy. During my PhD I completed a randomised controlled trial looking at the effectiveness and adverse effects of gabapentin medication in the treatment of chronic cough. The snake and spider studies that I now investigate have provided me with the opportunity to conduct three more RCTs testing the effects of medications.

My prior research focus was in the identification and treatment of patients with refractory and idiopathic chronic cough. Ten years of research in this area led to the significant finding that laryngeal hypersensitivity is common in refractory chronic cough patients and that this can be successfully treated with neuropathic medications such as gabapentin or by behavioural techniques such as speech pathology and cough suppression techniques.

Fields of Research

CodeDescriptionPercentage
111506Toxicology (Incl. Clinical Toxicology)60
111502Clinical Pharmacology And Therapeutics40

Memberships

Committee/Associations (relevant to research).

  • Member - ASMR

Appointments

NHMRC Early Career Clinical Research Fellow
University of Newcastle (Australia)
01/05/2014

Awards

Research Award.

2012HMRI Early Career Travel Award
HMRI (Australia)
HMRI Early Career Travel Award (International)
2012Faculty of Health Research Higher Degree Excellence Award
The University of Newcastle (Australia)
Research Higher Degree Excellence Award for PhD thesis
2011HMRI Pulse Education Prize
The University of Newcastle (Australia)
HMRI Pulse Education Prize
2008Finalist 10 of the Best Research Showcase
The University of Newcastle (Australia)
10 of the Best Research Showcase

Invitations

Gabapentin for refractory chronic cough: A randomised controlled trial
Thoracic Society of Australia and New Zealand, Australia (Invited Presenter)
2012

Teaching

Teaching keywords

  • TAFE (Chemistry)

Teaching expertise

PhD candidiate (thesis submitted December 2010) in Respiratory Medicine Research focusing on patients with chronic cough.

Brief teaching role at Newcastle TAFE to 3rd and 4th year Applied Science (Chemistry) students.

I expect to become more involved with PhD student projects within the snake bite project and other areas of clinical toxicology and will therefore receive valuable experience in the supervision of students to develop my career independence even further.

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Highlighted Publications

For publications that are currently unpublished or in-press, details are shown in italics.

YearCitationAltmetricsLink
2009Ryan NM, Gibson PG, 'Characterization of laryngeal dysfunction in chronic persistent cough', Laryngoscope, 119 640-645 (2009) [C1]
2012Ryan NM, Birring SS, Gibson PG, 'Gabapentin for refractory chronic cough: a randomised, double-blind, placebo-controlled trial', The Lancet, 380 1583-1589 (2012) [C1]

Co-authors: Peter Gibson

Publications

For publications that are currently unpublished or in-press, details are shown in italics.

Click on a category title below to expand the list of citations for that specific category.

Journal article (11 outputs)

YearCitationAltmetricsLink
2014Gibson PG, Simpson JL, Ryan NM, Vertigan AE, 'Mechanisms of cough', CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 14 55-61 (2014) [C1]
2014Ryan NM, Gibson PG, 'Recent additions in the treatment of cough.', J Thorac Dis, 6 S739-S747 (2014)
2014Ryan NM, Gibson PG, Birring SS, 'Arnold's nerve cough reflex: evidence for chronic cough as a sensory vagal neuropathy.', J Thorac Dis, 6 S748-S752 (2014)
2013Ryan NM, Birring SS, Gibson PG, 'Gabapentin for refractory chronic cough Reply', LANCET, 381 624-625 (2013) [C3]
2012Ryan NM, Birring SS, Gibson PG, 'Gabapentin for refractory chronic cough: a randomised, double-blind, placebo-controlled trial', The Lancet, 380 1583-1589 (2012) [C1]

Co-authors: Peter Gibson

2012Ryan NM, Vertigan AE, Ferguson JK, Wark PA, Gibson PG, 'Clinical and physiological features of postinfectious chronic cough associated with H1N1 infection', Respiratory Medicine, 106 138-144 (2012) [C1]
2011Gibson PG, Ryan NM, 'Cough pharmacotherapy: Current and future status', Expert Opinion on Pharmacotherapy, 12 1745-1755 (2011) [C1]

Co-authors: Peter Gibson

2010Ryan NM, Vertigan AE, Bone S, Gibson PG, 'Cough reflex sensitivity improves with speech language pathology management of refractory chronic cough', Cough, 6 1-8 (2010) [C1]

Co-authors: Peter Gibson

2009Ryan NM, Gibson PG, 'Characterization of laryngeal dysfunction in chronic persistent cough', Laryngoscope, 119 640-645 (2009) [C1]
2009Ryan NM, Vertigan AE, Gibson PG, 'Chronic cough and laryngeal dysfunction improve with specific treatment of cough and paradoxical vocal fold movement', Cough, 5 1-8 (2009) [C1]
2008Ryan NM, Gibson PG, 'Extrathoracic airway hyperresponsiveness as a mechanism of post infectious cough: Case report', Cough, 4 1-4 (2008) [C3]
Show 8 more

Conference (8 outputs)

YearCitationAltmetricsLink
2014Ryan NM, Brown SSGA, Isbister GK, 'Serum sickness after the administration of Australian snake antivenoms', CLINICAL TOXICOLOGY (2014) [E3]
2014Ryan NM, Isbister GK, 'Tramadol overdose is associated with an increased risk of seizure and unassociated with serotonin toxicity', TAPNA Conference Program, Newcastle, NSW (2014)
2013Ryan NM, 'Recent additions in the treatment of cough', J Thorac Dis, Guangzhou (2013) [E3]
2013Ryan NM, Vertigan AE, Bone SL, Gibson PG, 'Pregabalin and Speech Pathology for Chronic Cough', Journal of Thorac Disease, Guangzhou (2013) [E3]
2013Simpson JL, Baines KJ, Ryan NM, Gibson PG, 'NEUTROPHILIC ASTHMA IS CHARACTERIZED BY INCREASED GERD AND RHINOSINUSITIS WITH SLEEP DISTURBANCE', RESPIROLOGY (2013) [E3]
2012Ryan NM, Gibson PG, 'Gabapentin for idiopathic chronic cough: A randomised controlled trial', Lung, New York, NY (2012) [E3]

Co-authors: Peter Gibson

2011Ryan NM, Vertigan AE, Ferguson JK, Wark PA, Gibson PG, 'Investigation and characterization of persistent cough associated with H1N1 2009 influenza', Respirology, Perth, WA (2011) [E3]
2010Ryan NM, Vertigan AE, Bone S, Gibson PG, 'Cough reflex sensitivity improves with speech language pathology management of refractory chronic cough', Respirology, Brisbane, QLD (2010) [E3]
Show 5 more
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Grants and Funding

Summary

Number of grants5
Total funding$205,628

- Indicates that the researcher may be seeking students for this project.

Click on a grant title below to expand the full details for that specific grant.

2014 (1 grants)

Combined Treatment for Chronic Cough$152,300
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Doctor Nicole Ryan
SchemeRole
Early Career FellowshipsChief Investigator
Total AmountFunding StartFunding Finish
$152,30020142017
GNo:G1300679

2013 (2 grants)

Pregabalin and Speech Pathology Treatment for Refractory Chronic Cough with Laryngeal Hypersensitivity $23,810
Funding Body: John Hunter Hospital Charitable Trust Fund

Project Team
Doctor Nicole Ryan, Doctor Anne Vertigan, Doctor Michael Hayes, Ms Sarah Bone
SchemeRole
Research GrantChief Investigator
Total AmountFunding StartFunding Finish
$23,81020132013
GNo:G1300784

HMRI Early Career Travel Award 2012$6,000
Funding Body: Hunter Medical Research Institute

Project Team
Doctor Nicole Ryan
SchemeRole
Research GrantChief Investigator
Total AmountFunding StartFunding Finish
$6,00020132013
GNo:G1300514

2012 (1 grants)

PULSE Education Prize$4,000
Funding Body: Hunter Medical Research Institute

Project Team
Doctor Nicole Ryan
SchemeRole
PULSE Education PrizeChief Investigator
Total AmountFunding StartFunding Finish
$4,00020122012
GNo:G1200455

2007 (1 grants)

Mrs Nicole M Ryan$19,518
Funding Body: CCRE in Respiratory and Sleep Medicine

SchemeRole
Postgraduate Research ScholarshipInvestigator
Total AmountFunding StartFunding Finish
$19,51820072007
GNo:14937405
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Research Supervision

Number of current supervisions0

No Supervisions.

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Dr Nicole Ryan

Work Phone(02) 4921 1312
Fax(02) 4921 1870
Email
PositionPostdoctoral Research Fellow
Clinical Toxicology & Pharmacology
School of Medicine and Public Health
Faculty of Health and Medicine
The University of Newcastle, Australia
Focus AreaPublic Health
Office
5.46A, Level 5 New Med Building,
Calvary Mater Newcastle,
Calvary Mater Newcastle Hospital
URL:www.newcastle.edu.au/profile/nicole-ryan