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Dr Minjie Lin

Senior Lecturer

School of Environmental and Life Sciences (Biological Sciences)

Career Summary

Biography

* 1992, Ph D (Newcastle, Australia)

* 1999, work as the Project Co-ordinatorof the Marsupial CRC at Newcastle University. Since than, work on the sperm physiology and biochemistry has been published in the premier international journals of reproductive biology and anatomy and a provisional patent (IP Australia Patent Office No.6492).

*Up to 2003, research has been supported by the Marsupial Cooperative Research Centre in marsupial reproductive biology. My work has been recognized by international peers, and invited to give keynote speech at the International Symposium on Comparative Reproductive Biology in Vertebrates, Sun City, South Africa, in 2001.

*With the termination of the MCRC in 2004, I had to realign my research career from maruspial reproductive biology to eutherians, so that he can become competitive for NCG funds including linkage grants with industry.

*Currently, he is appointed as a senior lecturer at the School of Environmental Biology, and joined the Reproduction group at the Discipline of Biological Sciences.

Research Expertise
In animal reproductive physiology and biochemistry, specifically in the area of sperm formation in birds and mammals, including marsupials and monotremes. Currently research grants supported the following 4 research fields:

1. Kinetics of Sperm production in mammals and birds

2. Biochemical mechanism of sperm maturation in mammals

3. Separation of X- and Y- chromosome sperm

4. Identification of sperm proteins as contraceptive antigens

Teaching Expertise
Lectured on undergraduate courses such as animal physiology and development, reproductive physiology and development, biosciences (human physiology), and animal biology.

Administrative Expertise
University ACEC member



Qualifications

  • PhD, University of Newcastle
  • Master of Science (Agriculture), Jiangxi Agriculture University

Keywords

  • Animal Physiology
  • Developmental Biology
  • Human Physiology
  • Male Reproductive System
  • Sperm maturation in the epididymis
  • Spermatogenesis

Languages

  • Cantonese (Fluent)
  • Mandarin (Fluent)

Fields of Research

Code Description Percentage
060803 Animal Developmental and Reproductive Biology 35
111499 Paediatrics and Reproductive Medicine not elsewhere classified 65

Professional Experience

UON Appointment

Title Organisation / Department
Senior Lecturer University of Newcastle
School of Environmental and Life Sciences
Australia
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Journal article (27 outputs)

Year Citation Altmetrics Link
2014 Goldie BJ, Dun MD, Lin M, Smith ND, Verrills NM, Dayas CV, Cairns MJ, 'Activity-associated miRNA are packaged in Map1b-enriched exosomes released from depolarized neurons.', Nucleic Acids Research, 42 9195-9208 (2014) [C1]
DOI 10.1093/nar/gku594
Citations Scopus - 5Web of Science - 3
Co-authors Nikki Verrills, Matt Dun, Christopher Dayas, Murray Cairns
2011 Dun MD, Smith ND, Baker MA, Lin M, Aitken RJ, Nixon B, 'The chaperonin containing TCP1 complex (CCT/TRiC) is involved in mediating sperm-oocyte interaction', Journal of Biological Chemistry, 286 36875-36887 (2011) [C1]
DOI 10.1074/jbc.m110.188888
Citations Scopus - 19Web of Science - 18
Co-authors Brett Nixon, Matt Dun, John Aitken, Mark Baker
2011 Koppers AJ, Mitchell LA, Wang JP, Lin M, Aitken RJ, 'Phosphoinositide 3-kinase signalling pathway involvement in a truncated apoptotic cascade associated with motility loss and oxidative DNA damage in human spermatozoa', Biochemical Journal, 436 687-698 (2011) [C1]
DOI 10.1042/bj20110114
Citations Scopus - 42Web of Science - 41
Co-authors John Aitken
2009 Ren D, Xing Y, Lin M, Wu Y, Li K, Li W, et al., 'Evaluations of boar gonad development, spermatogenesis with regard to semen characteristics, libido and serum testosterone levels based on large white Duroc x Chinese Erhualian crossbred boars', Reproduction in Domestic Animals, 44 913-919 (2009) [C1]
DOI 10.1111/j.1439-0531.2008.01117.x
Citations Scopus - 8Web of Science - 8
2007 Aitken RJ, Nixon B, Lin M, Koppers AJ, Lee YH, Baker MA, 'Proteomic changes in mammalian spermatozoa during epididymal maturation', Asian Journal of Andrology, 9 554-564 (2007) [C1]
DOI 10.1111/j.1745-7262.2007.00280.x
Citations Scopus - 71Web of Science - 63
Co-authors Brett Nixon, John Aitken, Mark Baker
2006 Lin M, Lee YH, Xu W, Baker MA, Aitken RJ, 'Ontogeny of tyrosine phosphorylation-signaling pathways during spermatogenesis and epididymal maturation in the mouse', Biology of Reproduction, 75 588-597 (2006) [C1]
DOI 10.1095/biolreprod.106.052712
Citations Scopus - 16Web of Science - 16
Co-authors Mark Baker, John Aitken
2004 Lin M, Bielanowicz AJ, Fletcher TP, 'Cycle of the seminiferous epithelium in a marsupial species, the brushtail possum (Trichosurus vulpecula), and estimation of its duration', Reproduction Fertility and Development, 16 307-313 (2004) [C1]
DOI 10.1071/RD02059
Citations Scopus - 7Web of Science - 6
2004 Bennetts LE, Lin M, Aitken RJ, 'Cyclic AMP-Dependent Tyrosine Phosphorylation in Tammar Wallaby (Macropus eugenii) Spermatozoa', Journal of Experimental Zoology. Part A: Comparative Experimental Zoology, 301A 118-130 (2004) [C1]
DOI 10.1002/jez.a.20020
Citations Scopus - 10Web of Science - 9
Co-authors John Aitken
2002 Zhang X, Lin M, 'Tracing sperm acrosome differentiation in the testis and maturation in the epididymis of the tammar wallaby (Macropus eugenii) with a 45-kDa acrosome-membrane-associated protein', Reproduction Fertility and Development, 14 69-77 (2002) [C1]
2002 Lin M, Hess R, Aitken RJ, 'Induction of sperm maturation in vitro in epididymal cell cultures of the tammar wallaby (Macropus eugenii): disruption of motility initiation and sperm morphogenesis by inhibition of actin polymerization', Reproduction, 124 107-117 (2002) [C1]
Citations Scopus - 16Web of Science - 16
Co-authors John Aitken
2001 Scarlett CJ, Lin M, Aitken RJ, 'Actin polymerisation during morphogenesis of the acrosome as spermatozoa undergo epididymal maturation in the tammar wallaby (Macropus eugenii)', Journal of Anatomy, 198 93-101 (2001) [C1]
DOI 10.1017/S0021878200007299
Citations Scopus - 9Web of Science - 8
Co-authors John Aitken, C Scarlett
2000 Lin M, Jones RC, 'Spermiogenesis and spermiation in a monotreme mammal, the platypus, Ornithorhynchus anatinus', JOURNAL OF ANATOMY, 196 217-232 (2000) [C1]
Citations Web of Science - 19
2000 Lin M, Zhang X, Murdoch RN, Aitken RJ, 'In vitro culture of brushtail possum (Trichosurus vulpecula) epididymal epithelium and induction of epididymal sperm maturation in co-culture', Journal of Reproduction and Fertility, 119 1-14 (2000) [C1]
Citations Web of Science - 9
Co-authors John Aitken
1999 Lin M, Rodger JC, 'Acrosome formation during sperm transit through the epididymis in two marsupials, the tammar wallaby (Macropus eugenii) and the brushtailpossum (Trichosurus vulpecula)', Journal of Anatomy, 194 223-232 (1999) [C1]
Citations Web of Science - 11
Co-authors John Rodger
1999 Wade MA, Lin M, 'A 33 kDa molecular marker of sperm acrosome differentiation and maturation in the tammar wallaby (Macropus eugenii)', Journal of Reproduction and Fertility, 117 79-88 (1999) [C1]
Citations Web of Science - 1
1999 Murdoch RN, Jones RC, Wade MA, Lin M, 'The ultrastructure and metabolism of ejaculated tammar wallaby sperm are impaired by swim-up procedures when compared with sperm from the cauda epididymidis', Reproduction Fertility and Development, 11 263-271 (1999) [C1]
Citations Scopus - 2Web of Science - 2
1998 Lin M, Zhang X, Wade MA, Harris MS, Nickel M, 'Isolation of proteins from subacrosomal region of spermatozoa from a marsupial, the tammar wallaby (Macropus eugenii)', Journal of Reproduction and Fertility, 113 257-267 (1998) [C1]
Citations Web of Science - 3
Co-authors Merrilee Harris
1995 Lin M, Thorne MH, Martin ICA, Sheldon BL, Jones RC, 'Development of the gonads in the triploid (ZZW and ZZZ) fowl, Gallus domesticus, and comparison with normal diploid males (ZZ) and females (ZW)', REPRODUCTION FERTILITY AND DEVELOPMENT, 7 1185-1197 (1995)
DOI 10.1071/RD9951185
Citations Scopus - 35Web of Science - 35
1995 LIN M, THORNE MH, MARTIN ICA, SHELDON BL, JONES RC, 'ELECTRON-MICROSCOPY OF THE SEMINIFEROUS EPITHELIUM IN THE TRIPLOID (ZZZ AND ZZW) FOWL, GALLUS-DOMESTICUS', JOURNAL OF ANATOMY, 186 563-576 (1995)
Citations Scopus - 9Web of Science - 10
1994 REYNOLDS RJ, LITTLE GJ, LIN M, HEATH JW, 'IMAGING MYELINATED NERVE-FIBERS BY CONFOCAL FLUORESCENCE MICROSCOPY - INDIVIDUAL FIBERS IN WHOLE NERVE TRUNKS TRACED THROUGH MULTIPLE CONSECUTIVE INTERNODES', JOURNAL OF NEUROCYTOLOGY, 23 555-564 (1994)
DOI 10.1007/BF01262056
Citations Web of Science - 17
1993 LIN M, JONES RC, 'SPERMIOGENESIS AND SPERMIATION IN THE JAPANESE-QUAIL (COTURNIX-COTURNIX-JAPONICA)', JOURNAL OF ANATOMY, 183 525-535 (1993)
Citations Scopus - 33Web of Science - 32
1993 SISTINA Y, LIN M, MATE KE, RODGER JC, 'INDUCTION OF THE MARSUPIAL SPERM ACROSOME REACTION IN-VITRO BY TREATMENT WITH DIACYLGLYCEROLS', JOURNAL OF REPRODUCTION AND FERTILITY, 99 335-341 (1993)
Citations Scopus - 15Web of Science - 16
Co-authors John Rodger, Karen Mate
1992 JONES RC, LIN M, 'ULTRASTRUCTURE OF THE GENITAL DUCT EPITHELIUM OF THE MALE PORT JACKSON SHARK, HETERODONTUS-PORTUSJACKSONI', AUSTRALIAN JOURNAL OF ZOOLOGY, 40 257-266 (1992)
DOI 10.1071/ZO9920257
Citations Web of Science - 7
1992 LIN M, JONES RC, 'RENEWAL AND PROLIFERATION OF SPERMATOGONIA DURING SPERMATOGENESIS IN THE JAPANESE-QUAIL, COTURNIX-COTURNIX-JAPONICA', CELL AND TISSUE RESEARCH, 267 591-601 (1992)
DOI 10.1007/BF00319382
Citations Scopus - 27Web of Science - 29
1990 SUJARIT S, JONES RC, SETCHELL BP, CHATURAPANICH G, LIN M, CLULOW J, 'STIMULATION OF PROTEIN SECRETION IN THE INITIAL SEGMENT OF THE RAT EPIDIDYMIS BY FLUID FROM THE RAM RETE TESTIS', JOURNAL OF REPRODUCTION AND FERTILITY, 88 315-321 (1990)
Citations Scopus - 11Web of Science - 23
Co-authors John Clulow
1990 LIN M, JONES RC, BLACKSHAW AW, 'THE CYCLE OF THE SEMINIFEROUS EPITHELIUM IN THE JAPANESE QUAIL (COTURNIX-COTURNIX-JAPONICA) AND ESTIMATION OF ITS DURATION', JOURNAL OF REPRODUCTION AND FERTILITY, 88 481-490 (1990)
Citations Scopus - 25Web of Science - 27
1990 LIN M, JONES RC, 'SPATIAL ARRANGEMENT OF THE STAGES OF THE CYCLE OF THE SEMINIFEROUS EPITHELIUM IN THE JAPANESE-QUAIL, COTURNIX-COTURNIX-JAPONICA', JOURNAL OF REPRODUCTION AND FERTILITY, 90 361-367 (1990)
Citations Scopus - 12Web of Science - 14
Show 24 more journal articles

Conference (1 outputs)

Year Citation Altmetrics Link
2006 Aitken RJ, Baker MA, Lee YH, Lin M, Nixon B, 'Proteomic Changes in Mouse Spermatozoa During Epididymal Transit', Abstracts, Chatel-Guyon, Auvergne, France (2006) [E3]
Co-authors John Aitken, Mark Baker, Brett Nixon
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Grants and Funding

Summary

Number of grants 20
Total funding $807,568

Click on a grant title below to expand the full details for that specific grant.


20141 grants / $2,000

Faculty PVC Conference Assistance Grant 2014$2,000

Funding body: University of Newcastle - Faculty of Science & IT

Funding body University of Newcastle - Faculty of Science & IT
Project Team Doctor Minjie Lin
Scheme PVC Conference Assistance Grant
Role Lead
Funding Start 2014
Funding Finish 2014
GNo G1401222
Type Of Funding Internal
Category INTE
UON Y

20093 grants / $726,000

The roles of cytoskeletal proteins on the fertilization and embryonic development in a marine invertebrate, Galeolaria caespitose$6,000

Funding body: Newcastle Innovation

Funding body Newcastle Innovation
Project Team Doctor Minjie Lin
Scheme Administered Research
Role Lead
Funding Start 2009
Funding Finish 2009
GNo G0190608
Type Of Funding Internal
Category INTE
UON Y

20041 grants / $10,000

Development of an in vitro system for studying the maturation of mammalian spermatozoa$10,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Doctor Minjie Lin, Laureate Professor John Aitken
Scheme Project Grant
Role Lead
Funding Start 2004
Funding Finish 2004
GNo G0183402
Type Of Funding Internal
Category INTE
UON Y

20022 grants / $10,218

Identification of sperm-specific actin regulators which control acrosomal shaping in the epididymis$6,500

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Doctor Minjie Lin, Conjoint Associate Professor Russell Jones
Scheme Project Grant
Role Lead
Funding Start 2002
Funding Finish 2002
GNo G0181360
Type Of Funding Internal
Category INTE
UON Y

Visit of Prof W Fu, from 5 August 2002 to 23 September 2002$3,718

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Doctor Minjie Lin
Scheme Visitor Grant
Role Lead
Funding Start 2002
Funding Finish 2002
GNo G0181900
Type Of Funding Internal
Category INTE
UON Y

20013 grants / $9,800

Identification of regulators of actin filament assembly and disassembly to shape sperm acrosome.$5,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Doctor Minjie Lin
Scheme Project Grant
Role Lead
Funding Start 2001
Funding Finish 2001
GNo G0180021
Type Of Funding Internal
Category INTE
UON Y

The 16th International Symposium on Morphological Sciences, South Africa 22-26 July 2001$2,400

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Doctor Minjie Lin
Scheme Travel Grant
Role Lead
Funding Start 2001
Funding Finish 2001
GNo G0180748
Type Of Funding Internal
Category INTE
UON Y

Third International Conference on Epididymis - Virginia, USA - 29/5/02 - 1/06/02$2,400

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Doctor Minjie Lin
Scheme Travel Grant
Role Lead
Funding Start 2001
Funding Finish 2001
GNo G0181636
Type Of Funding Internal
Category INTE
UON Y

20002 grants / $8,900

Using in vitro co-culture systems to investigate the role of actin filaments on sperm maturation in Australian marsupials.$6,500

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Doctor Minjie Lin
Scheme Project Grant
Role Lead
Funding Start 2000
Funding Finish 2000
GNo G0178941
Type Of Funding Internal
Category INTE
UON Y

11th European Workshop on Molecular and Cellular Endocrinology of the Testis.$2,400

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Doctor Minjie Lin
Scheme Travel Grant
Role Lead
Funding Start 2000
Funding Finish 2000
GNo G0180272
Type Of Funding Internal
Category INTE
UON Y

19981 grants / $9,500

The culture of epithelial cells from the male reproductive tract of the tammar wallaby and the in vitro maturation of sperm$9,500

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Doctor Minjie Lin, Raymond Murdoch
Scheme Project Grant
Role Lead
Funding Start 1998
Funding Finish 1998
GNo G0177292
Type Of Funding Internal
Category INTE
UON Y

19971 grants / $2,400

10th European Workshop on Molecular and Cellular Endocrinology of the testis, Italy 28 March - 1 April 1998$2,400

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Doctor Minjie Lin
Scheme Travel Grant
Role Lead
Funding Start 1997
Funding Finish 1997
GNo G0180281
Type Of Funding Internal
Category INTE
UON Y

19962 grants / $9,400

Local regulation of the spermatogenesis in the quail:Secretions of the inhibin and activin during the cycle of the seminiferous epithelium.$7,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Doctor Minjie Lin
Scheme Project Grant
Role Lead
Funding Start 1996
Funding Finish 1996
GNo G0175725
Type Of Funding Internal
Category INTE
UON Y

9th European Testis Workshop on Molecular and Cellular Endocrinology - Norway - 14-19/4/96$2,400

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Doctor Minjie Lin
Scheme Travel Grant
Role Lead
Funding Start 1996
Funding Finish 1996
GNo G0176036
Type Of Funding Internal
Category INTE
UON Y

19951 grants / $8,000

Local regulation of the spermatogenesis in the quail: Secretions of the inhibin and activin during the cycle of the seminiferours epithelium.$8,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Doctor Minjie Lin
Scheme Project Grant
Role Lead
Funding Start 1995
Funding Finish 1995
GNo G0174846
Type Of Funding Internal
Category INTE
UON Y

19942 grants / $5,850

Spermatogenesis in the Platypus (Ornithorhynchus anatinus)$4,500

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Doctor Minjie Lin
Scheme Project Grant
Role Lead
Funding Start 1994
Funding Finish 1994
GNo G0174752
Type Of Funding Internal
Category INTE
UON Y

'8th European Workshop on Molecular and Cellular Endocrinology of the Testis', De Panne, Belgium, 27 - 31 March 1994$1,350

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Doctor Minjie Lin
Scheme Travel Grant
Role Lead
Funding Start 1994
Funding Finish 1994
GNo G0174448
Type Of Funding Internal
Category INTE
UON Y

19931 grants / $5,500

93GRANT.Spermatogenesis in the Platypus (Ornithorhynchus anatinus)$5,500

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Doctor Minjie Lin
Scheme New Staff Grant
Role Lead
Funding Start 1993
Funding Finish 1993
GNo G0172888
Type Of Funding Internal
Category INTE
UON Y
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Research Supervision

Current Supervision

Commenced Research Title / Program / Supervisor Type
2013 Study Spermatogenesis in a Native Marine Invertebrate Galeolaria Caespitosa and Investigate it's Potential as a Biomarker for Marine Pollution
Biological Sciences, Faculty of Science and Information Technology
Principal Supervisor

Past Supervision

Year Research Title / Program / Supervisor Type
2009 Functional Maturation of Mouse Epididymal Spermatozoa
Biological Sciences, Faculty of Science and Information Technology
Co-Supervisor
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Dr Minjie Lin

Position

Senior Lecturer
School of Environmental and Life Sciences
Faculty of Science and Information Technology

Focus area

Biological Sciences

Contact Details

Email minjie.lin@newcastle.edu.au
Phone (02) 4921 5707
Fax (02) 4921 5472

Office

Room LS4-49
Building Life Sciences
Location Callaghan
University Drive
Callaghan, NSW 2308
Australia
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