Staff Profile

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Career Summary

Biography

 

Dr. Yang graduated from The John Curtin School of Medical Research, Institute of Advanced Studies, Australian National University, with distinction: he was awarded the prestigious Frank Fenner Medal for the  most  outstanding  PhD  dissertation.  Subsequently he was awarded  a prestigious University of Newcastle Research Fellowship and was promoted to level B within the first year after graduation.  Based on his research directions and productivity, he was awarded an NHMRC New Investigator grant. In 2012, he was promoted to Senior Research Fellow. He is now internationally known for his investigations into the pathogenesis of asthma, and the molecular and cellular regulation of inflammation.

Dr. Yang’s group has received international recognition through publication in leading biomedical science journals and has contributed to more than 30 refereed manuscripts in high impact journals (J Exp Med, J Clin Invest, Gastroenterology, J Allergy Clin Immunology, PNAS, J Immunology) with more than 1500 combined citations. He has been successful in obtaining research grants both indendently and in collaboration with other investigators (over $3.8 Million). 

Research Directions and Significant Achievements: In recent years Dr. Yang has initiated investigations into the mechanisms that regulate steroid resistant inflammatory pathways in the lung, to help understand how steroid resistance may develop in asthma. Understanding the mechanisms that regulate steroid-resistant inflammation is important and developing novel non- steroidal therapeutic approaches to the disease will be highly beneficial, as these patients suffer greater morbidity and mortality. Currently, there is no effective treatment and there is very limited functional evidence of the way in which the inflammatory pathways are activated in these patients. Building on clinical studies, we have recently demonstrated, for the first time, that macrophages are crucial in regulating steroid-resistant inflammatory signals. Two papers have been published in the Journal of Immunology and their significance has been recognised by the American Academy of Asthma Allergy and Immunology (symposium invitation, 2010) and the invitation to write two reviews for Current Drug Targets and Journal of Leukocyte Biology.

The unique complexity of respiratory system has limited the development of therapeutic agents that show clinical benefit for severe asthmatic patients. However, the more efficient therapeutics may be developed by silencing the dominant proinflammatory genes, which are responsible for the propagation of the disease. Employing small ‘non-coding’ RNA molecules called microRNAs (miRNA), small interfering RNAs (siRNA) or synthetic analogues of these molecules, ‘antagomirs’, to specifically silence aberrant gene function is of growing interest. Dr. Yang was at the forefront of the first application of RNA interference to modulate AHR and macrophage function in the lung (2006, J Immunology). His works in this field has been recognised by invitations to write reviews for Drug Discovery Today, Pharmacology & Therapeutics and American Journal of Respiratory Cellular and Molecular Biology. Recently, he has been investigating the central roles of miRNA in the regulation of the pro-inflammatory effects of macrophages and thus potential innate immune mediated AHR. Dr. Yang also has extensive research interests in characterizing the pivotal roles of these small non-coding RNAs in modulating the differentiation and function of granulocytes and other immune cells.

Qualifications

  • PhD, Australian National University, 20/04/2003

Research

Research keywords

  • Gene Regulation
  • Haematopoiesis
  • Infectious Disease
  • Inflammation Inhibition
  • Intracellular Signalling Transduction
  • Respiratory Disease

Research expertise

  • Immunology
  • Pharmacology
  • Pharmaceutical Sciences

Languages

  • Chinese
  • English

Fields of Research

CodeDescriptionPercentage
110299Cardiovascular Medicine And Haematology Not Elsewhere Classified80
110399Clinical Sciences Not Elsewhere Classified20

Collaboration

Dr. Yang has productive collaborations within Australia and oversea internationally renowned groups. He has extensive academic, intellectual and procedural input into these collaborations and has also contributed significant experimental expertise. These collaborations will continue for the foreseeable future.

Teaching

Teaching keywords

  • Immunology
  • Pharmaceutical Sciences
  • Pharmacology
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.

Click on a category title below to expand the list of citations for that specific category.

Journal article (27 outputs)

YearCitationAltmetricsLink
2013Li JJ, Tay HL, Plank M, Essilfie A-T, Hansbro PM, Foster PS, Yang M, 'Activation of Olfactory Receptors on Mouse Pulmonary Macrophages Promotes Monocyte Chemotactic Protein-1 Production', PLOS ONE, 8 (2013) [C1]
2013Beckett EL, Stevens RL, Jarnicki AG, Kim RY, Hanish I, Hansbro NG, et al., 'A new short-term mouse model of chronic obstructive pulmonary disease identifies a role for mast cell tryptase in pathogenesis', The Journal of Allergy and Clinical Immunology, 131 752-762 (2013) [C1]
2013Eftekhari P, Hajizadeh S, Reza Raoufy M, Reza Masjedi M, Yang M, Hansbro N, et al., 'Preventive effect of N-acetylcysteine in a mouse model of steroid resistant acute exacerbation of asthma', EXCLI Journal, 12 184-192 (2013) [C1]
2013Foster PS, Plank MW, Collison AM, Tay HL, Kaiko GE, Li J, et al., 'The emerging role of microRNAs in regulating immune and inflammatory responses in the lung', Immunological Reviews, 253 198-215 (2013) [C1]
2013Hansbro PM, Scott GV, Essilfie A-T, Kim RY, Starkey MR, Nguyen D, et al., 'Th2 cytokine antagonists: Potential treatments for severe asthma', Expert Opinion on Investigational Drugs, 22 49-69 (2013) [C1]
2012Yang M, Kumar RK, Hansbro PM, Foster PS, 'Emerging roles of pulmonary macrophages in driving the development of severe asthma', Journal of Leukocyte Biology, 91 557-569 (2012) [C1]
2012Kumar RK, Yang M, Herbert C, Foster PS, 'Interferon-¿, pulmonary macrophages and airway responsiveness in asthma', Inflammation and Allergy - Drug Targets, 11 292-297 (2012) [C1]

Co-authors: Paul Foster

2011Wang W, Hansbro PM, Foster PS, Yang M, 'An alternate STAT6-independent pathway promotes eosinophil influx into blood during allergic airway inflammation', PLoS ONE, 6 e17766 (2011) [C1]
2010Yang M, Kumar RK, Foster PS, 'Interferon-Y and pulmonary macrophages contribute to the mechanisms underlying prolonged airway hyperresponsiveness', Clinical and Experimental Allergy, 40 163-173 (2010) [C1]
2010Hardy CL, Lemasurier JS, Olsson F, Dang T, Yao J, Yang M, et al., 'Interleukin-13 regulates secretion of the tumor growth factor-beta superfamily cytokine activin A in allergic airway inflammation', American Journal of Respiratory Cell and Molecular Biology, 42 667-675 (2010) [C1]
2010Li J, Wang W, Baines KJ, Bowden NA, Hansbro PM, Gibson PG, et al., 'IL-27/IFN-y induce MyD88-dependent steroid-resistant airway hyperresponsiveness by inhibiting glucocorticoid signaling in macrophages', Journal of Immunology, 185 4401-4409 (2010) [C1]
2010Wang W, Li J, Foster PS, Hansbro PM, Yang M, 'Potential therapeutic targets for steroid-resistant asthma', Current Drug Targets, 11 957-970 (2010) [C1]
2009Yang M, Kumar RK, Foster PS, 'Pathogenesis of steroid-resistant airway hyperresponsiveness: Interaction between IFN-gamma and TLR4/MyD88 pathways', Journal of Immunology, 182 5107-5115 (2009) [C1]
2008Yang M, Mattes J, 'Discovery, biology and therapeutic potential of RNA interference, microRNA and antagomirs', Pharmacology & Therapeutics, 117 94-104 (2008) [C1]
2007Mattes J, Yang M, Foster PS, 'Regulation of microRNA by antagomirs: a new class of pharmacological antagonists for the specific regulation of gene function?', American Journal of Respiratory and Cellular Molecular Biology, 36 8-12 (2007) [C1]
2007Webb DC, Yang M, Matthaei (Ext) K, Foster PS, 'Comparative roles of IL-4, IL-13, and IL-4Ralpha in dendritic cell maturation and CD4+ Th2 cell function', Journal of Immunology, 178 219-227 (2007) [C1]

Co-authors: Paul Foster

2006Yang M, Rangasamy D, Matthaei KI, Frew AJ, Zimmmermann N, Mahalingam S, et al., 'Inhibition of arginase I activity by RNA interference attenuates IL-13-induced airways hyperresponsiveness', Journal of Immunology, 177 5595-5603 (2006) [C1]

Co-authors: Paul Foster

2006Yang M, Mattes J, Hansbro PM, Foster PS, 'Employment of microRNA profiles and RNA interference and antagomirs for the characterization and treatment of respiratory disease', Drug Discovery Today: Therapeutic Strategies, 3 325-332 (2006) [C1]
2006Siegle JS, Hansbro NG, Herbert C, Yang M, Foster PS, Kumar RK, 'Airway hyperreactivity in exacerbation of chronic asthma is independent of elosinophilic inflammation', American Journal of Respiratory Cell and Molecular Biology, 35 565-570 (2006) [C1]
2006Yang M, Rangasamy D, Matthaei K, Frew A, Zimmmermann N, Mahalingham S, et al., 'Inhibition of arginase I activity by RNA interference attenuates interleukin-13 induced airways hyperresponsiveness', ACTA PHARMACOLOGICA SINICA, 27 266-266 (2006)
2004Fulkerson PC, Zimmermann N, Brandt EB, Muntel EE, Doepker MP, Kavanaugh JL, et al., 'Negative regulation of eosinophil recruitment to the lung by the chemokine monokine induced by INF-g (Mig, CXCL9)', Proceedings of the National Academy of Sciences of the USA, 101 1987-1992 (2004) [C1]
2004Forbes E, Smart V, D'Aprile A, Henry P, Yang M, Matthaei KI, et al., 'T Helper-2 Immunity Regulates Bronchial Hyperresponsiveness in Eosinophil-Associated Gastrointestinal Disease in Mice', Gastroenterology, 127 105-118 (2004) [C1]
2004Forbes E, Murase T, Yang M, Matthaei KI, Lee JJ, Lee NA, et al., 'Immunopathogenesis of experimental ulcerative colitis is mediated by eosinophil peroxidase1', J Immunol, 172 5664-5675 (2004) [C1]

Co-authors: Paul Foster

2003Kumar RK, Herbert C, Thomas PS, Wollin L, Beume R, Yang M, et al., 'Inhibition of inflammation and remodeling by roflumilast and dexamethasone in murine chronic asthma', Journal of Pharmacology and Experimental Therapeutics, 307 349-355 (2003) [C1]
2003Zimmerman N, King NE, Laporte J, Yang M, Mishra A, Pope S, et al., 'Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis', Journal of Clinical Investigation, 111 1863-1874 (2003) [C1]
2003Foster PS, Webb DC, Yang M, Herbert C, Kumar RK, 'Dissociation of T helper type 2 cytokine-dependent airway lesions from signal transducer and activator of transcription 6 signalling in experimental chronic asthma', Clinical and Experimental Allergy, 33 688-695 (2003) [C1]
2003Yang M, Hogan SP, Mahalingam S, Pope SM, Zimmerman N, Fulkerson P, et al., 'Eotaxin-2 and IL-5 cooperate in the lung to regulate IL-13 production and airway eosinophilia and hyperreactivity', Journal of Allergy and Clinical Immunology, 112 935-943 (2003) [C1]
Show 24 more

Conference (3 outputs)

YearCitationAltmetricsLink
2013Hansbro P, Beckett E, Stevens R, Jarnicki A, Kim R, Hanish I, et al., 'A short-term model of COPD identifies a role for mast cell tryptase', JOURNAL OF IMMUNOLOGY, Honolulu, HI (2013) [E3]
2012Li J, Foster PS, Yang M, 'Inducible microRNA-X expression underpins steroid- resistant airway hyperresponsiveness by upregulating IL-27 expression', Respirology, Canberra, ACT (2012) [E3]

Co-authors: Paul Foster

2008Yang M, Ma C, Foster PS, 'Antigen-specific TH1 cells induce airway hyper-reactivity in co-operation with lipopolysaccharide in BALB/C mice', Respirology, Melbourne, VIC (2008) [E3]
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Grants and Funding

Summary

Number of grants18
Total funding$4,567,323

- Indicates that the researcher may be seeking students for this project.

Click on a grant title below to expand the full details for that specific grant.

2014 (1 grants)

New way of treating respiratory infections and airway inflammatory diseases by targeting miRNA $677,562
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Paul Foster, Doctor Ming Yang
SchemeRole
Project GrantInvestigator
Total AmountFunding StartFunding Finish
$677,56220142016
GNo:G1300121

2013 (1 grants)

DP73 Digital colour and monochrome camera + cellSens software + Xcite120 fluorescence lamp illuminator$20,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Paul Foster, Doctor Alan Hsu, Professor Phil Hansbro, Professor Joerg Mattes, Doctor Katie Baines, Associate Professor Jodie Simpson, Professor Rakesh Kumar, Doctor Nicole Hansbro, Doctor Steven Maltby, Doctor Ming Yang, Doctor Gerard Kaiko, Doctor Jay Horvat, Doctor Simon Keely, Doctor Andrew Jarnicki, Doctor Michael Fricker
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$20,00020132013
GNo:G1201186

2012 (2 grants)

Understanding the mechanisms of steroid resistant inflammatory pathways in mouse models of asthma: potential new treatment approaches$514,551
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Paul Foster, Doctor Ming Yang
SchemeRole
Project GrantInvestigator
Total AmountFunding StartFunding Finish
$514,55120122014
GNo:G1100099

SpectraMax M5e Multi-Mode Microplate Reader$50,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Paul Foster, Professor Phil Hansbro, Professor Joerg Mattes, Professor Rakesh Kumar, Doctor Nicole Hansbro, Doctor Ming Yang, Doctor Jay Horvat, Doctor Simon Keely, Doctor Andrew Jarnicki, Doctor Linda Howland, Doctor Kelly Asquith
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$50,00020122012
GNo:G1100975

2011 (3 grants)

Targeting pro-survival mechanisms to sensitize human melanoma to immunotherapy$359,250
Funding Body: Cancer Council NSW

Project Team
Professor Xu Dong Zhang, Doctor Ming Yang
SchemeRole
Research ProgramInvestigator
Total AmountFunding StartFunding Finish
$359,25020112013
GNo:G1000379

SCIREQ FlexiVentFX system + FlexiVentFX extension$45,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Phil Hansbro, Professor Paul Foster, Professor Joerg Mattes, Doctor Simon Keely, Doctor Jay Horvat, Doctor Nicole Hansbro, Doctor Ming Yang, Doctor Catherine Ptaschinski, Doctor Kelly Asquith, Doctor Gough Au, Conjoint Professor Peter Wark, Laureate Professor John Aitken, Conjoint Professor Keith Jones, Professor Roger Smith, Professor Judith Black, Professor Rakesh Kumar, Professor Paul Hertzog
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$45,00020112011
GNo:G1100037

Targeting Pro-Survival Mechanisms to Sensitize Human Melanoma to Immunotherapy$25,000
Funding Body: University of Newcastle

Project Team
Professor Xu Dong Zhang, Doctor Ming Yang
SchemeRole
Near Miss GrantInvestigator
Total AmountFunding StartFunding Finish
$25,00020112011
GNo:G1001046

2010 (2 grants)

Buxco FinePointe software and FinePointe RC system for mice $39,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Paul Foster, Professor Phil Hansbro, Professor Joerg Mattes, Doctor Nicole Hansbro, Doctor Simon Phipps, Doctor Ming Yang, Doctor Kelly Asquith, Doctor Catherine Ptaschinski, Professor Rakesh Kumar, Professor Judith Black
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$39,00020102010
GNo:G1000053

40th Annual Scientific Meting for Australiasian Society for Immunology 2010, Perth, 5 - 9 December 2010$1,509
Funding Body: University of Newcastle - Faculty of Health and Medicine

Project Team
Doctor Ming Yang
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$1,50920102010
GNo:G1001004

2009 (1 grants)

Coulter counter$41,150
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Paul Foster, Professor Phil Hansbro, Professor Joerg Mattes, Doctor Simon Phipps, Doctor Ming Yang, Doctor Nicole Hansbro, Doctor Kelly Asquith
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$41,15020092009
GNo:G0189851

2008 (4 grants)

Innate immune factors regulate steroid-resistant airways hyperreactivity and asthma$503,250
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Doctor Ming Yang
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$503,25020082010
GNo:G0187617

Individually ventilated cages (IVC) and associated ventilator, holding boxes and water bottles$35,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Paul Foster, Professor Phil Hansbro, Professor Joerg Mattes, Doctor Simon Phipps, Doctor Ming Yang, Doctor Nicole Hansbro, Doctor Kelly Asquith
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$35,00020082008
GNo:G0188541

MicroRNA and antagomirs in the regulation and suppression of interferon (IFN)-g and lipopolysaccharide (LPS) induced steroid-resistant airways hyperreactivity$24,250
Funding Body: Hunter Medical Research Institute

Project Team
Doctor Ming Yang, Professor Paul Foster
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$24,25020082008
GNo:G0188474

The Thoracic Society of Australia and New Zealand Annual Scientific Meeting, Melbourne Australia, 30/3/2008 - 2/4/2008$1,700
Funding Body: University of Newcastle

Project Team
Doctor Ming Yang
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$1,70020082008
GNo:G0188618

2006 (1 grants)

15th World Congress of pharmacology july 2-7, 2006$1,500
Funding Body: University of Newcastle

Project Team
Doctor Ming Yang
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$1,50020062006
GNo:G0186492

2005 (3 grants)

Drug targets from new animal models$2,030,948
Funding Body: CRC for Asthma

Project Team
Professor Paul Foster, Professor Phil Hansbro, Professor Joerg Mattes, Doctor Ming Yang, Dr Simon Phipps
SchemeRole
Research GrantInvestigator
Total AmountFunding StartFunding Finish
$2,030,94820052011
GNo:G0185860

Understanding the role of IL-13 in the pathogenesis of asthma$168,173
Funding Body: University of Newcastle

Project Team
Doctor Ming Yang
SchemeRole
Postdoctoral Research FellowshipChief Investigator
Total AmountFunding StartFunding Finish
$168,17320052007
GNo:G0184063

Investigating the role of IL-13 induced arginas I activity in the development of allergic lung disease$29,480
Funding Body: Ramaciotti Foundations

Project Team
Doctor Ming Yang
SchemeRole
Major Equipment AwardChief Investigator
Total AmountFunding StartFunding Finish
$29,48020052005
GNo:G0185636
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Research Supervision

Number of current supervisions2
Total current UoN PhD EFTSL0.9

For supervisions undertaken at an institution other that the University of Newcastle, the institution name is listed below the program name.

Current Supervision

CommencedProposed
Completion
ProgramSupervisor TypeResearch Title
20122016PhD (Immunology & Microbiol)Principal SupervisorUnderstanding the mechanisms of airway hyper-responsiveness in a mouse model of asthma
20122016PhD (Immunology & Microbiol)Principal SupervisorRoles of Bromodomain and extra terminal (BET) proteins in Suppression of Airway Inflammation

Past Supervision

YearProgramSupervisor TypeResearch Title
2014PhD (Immunology & Microbiol)Principal SupervisorRespiratory Innate Immune Factors Regulate Steroid-resistant Airway Hyperreactivity and Asthma
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Dr Ming Yang

Work Phone(02) 40420183
Email
PositionSenior Research Fellow
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine
The University of Newcastle, Australia
Focus AreaImmunology and Microbiology
Office
Level 2, Immunology & Microbiology,
HMRI Building,
HMRI Building
URL:www.newcastle.edu.au/profile/ming-yang
Linkhttp://www.newcastle.edu.au/school/biomedical-science/staff/MingYang.html