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Dr Michela Simone

Lecturer

School of Environmental and Life Sciences

Career Summary

Qualifications

  • PhD (Organic Chemistry), University of Oxford - UK

Keywords

  • carbohydrate chemistry
  • glycobiology
  • medicinal chemistry

Fields of Research

CodeDescriptionPercentage
030401Biologically Active Molecules50
030499Medicinal and Biomolecular Chemistry not elsewhere classified50

Professional Experience

UON Appointment

DatesTitleOrganisation / Department
6/01/2015 - LecturerUniversity of Newcastle
School of Environmental and Life Sciences
Australia
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Journal article (36 outputs)

YearCitationAltmetricsLink
2015Cossar PJ, Hizartzidis L, Simone MI, McCluskey A, Gordon CP, 'The expanding utility of continuous flow hydrogenation.', Org Biomol Chem, 13 7119-7130 (2015)
DOI10.1039/c5ob01067eAuthor URL
Co-authorsAdam Mccluskey
2015Cossar PJ, Hizartzidis L, Simone MI, McCluskey A, Gordon C, 'The expanding utility of continuous flow hydrogenation', Org. Biomol. Chem., (2015)
DOI10.1039/C5OB01067E
2014Simone MI, Houston TA, 'A Brief Overview of Recent Advances in the Applications of Boronic Acids Relevant to Glycomics', Journal of Glycomics & Lipidomics, 04 e124 (2014) [C3]
DOI10.4172/2153-0637.1000e124
2014Hizartzidis L, Cossar PJ, Robertson MJ, Simone MI, Young KA, McCluskey A, Gordon CP, 'Expanding the utility of flow hydrogenation - A robust protocol restricting hydrodehalogenation', RSC Advances, 4 56743-56748 (2014) [C1]

A commonly observed limitation of conducting hydrogenations under flow chemistry conditions is hydrodehalogenation. In a bid to circumvent this limitation a series of hydrogenation catalysts were screened, with 5% Pt/C (sulfided) catalyst identified as an effective catalyst to selectively effect reductive aminations, nitro reduction, and alkene reductions in the presence of halogen atoms. Additionally the optimised protocol cleanly reduced imines in the presence of a furan moiety indicating potential amenability to other labile functionalities.

DOI10.1039/c4ra09605c
CitationsScopus - 1Web of Science - 1
Co-authorsAdam Mccluskey
2014Moyes AJ, Khambata RS, Villar I, Bubb KJ, Baliga RS, Lumsden NG, et al., 'Endothelial C-type natriuretic peptide maintains vascular homeostasis', Journal of Clinical Investigation, 1 (2014) [C1]
DOI10.1172/JCI74281
CitationsScopus - 1Web of Science - 2
2014Sayer JR, Wallde n K, Pesnot T, Campbell F, Gane PJ, Simone M, et al., '2- and 3-substituted imidazo[1,2-a]pyrazines as inhibitors of bacterial type IV secretion', Bioorganic and Medicinal Chemistry, (2014) [C1]

A novel series of 8-amino imidazo[1,2-a]pyrazine derivatives has been developed as inhibitors of the VirB11 ATPase HP0525, a key component of the bacterial type IV secretion system. A flexible synthetic route to both 2- and 3-aryl substituted regioisomers has been developed. The resulting series of imidazo[1,2-a]pyrazines has been used to probe the structure-activity relationships of these inhibitors, which show potential as antibacterial agents.

DOI10.1016/j.bmc.2014.09.036
2013Risseeuw M, Overhand M, Fleet GWJ, Simone MI, 'A compendium of cyclic sugar amino acids and their carbocyclic and heterocyclic nitrogen analogues', Amino Acids, 45 613-689 (2013) [C1]
DOI10.1007/s00726-013-1521-1Author URL
CitationsScopus - 12Web of Science - 11
2013Reed JH, Turner P, Kato A, Houston TA, Simone M, '1-O-Benzyl-2,3-O-isopropylidene-6-O-tosyl-a-L-sorbofuranose', Acta Crystallographica Section E: Structure Reports Online, 69 o1069-o1070 (2013) [C1]
DOI10.1107/S1600536813015638
2012Dube H, Selwood D, Malouitre S, Capano M, Simone MI, Crompton M, 'A mitochondrial-targeted cyclosporin A with high binding affinity for cyclophilin D yields improved cytoprotection of cardiomyocytes', BIOCHEMICAL JOURNAL, 441 901-907 (2012) [C1]
DOI10.1042/BJ20111301Author URL
CitationsScopus - 14Web of Science - 9
2012Simone MI, Soengas RG, Jenkinson SF, Evinson EL, Nash RJ, Fleet GWJ, 'Synthesis of three branched iminosugars [(3R,4R,5S)-3-(hydroxymethyl)piperidine-3,4,5-triol, (3R,4R,5R)-3-(hydroxymethyl)piperidine-3,4,5-triol and (3S,4R,5R)-3-(hydroxymethyl)piperidine-3.4,5-triol] and a branched trihydroxynipecotic acid [(3R,4R,5R)-3,4,5-trihydroxypiperidine-3-carboxylic acid] from sugar lactones with a carbon substituent at C-2', TETRAHEDRON-ASYMMETRY, 23 401-408 (2012) [C1]
DOI10.1016/j.tetasy.2012.03.007Author URL
CitationsScopus - 9Web of Science - 8
2012Soengas RG, Simone MI, Hunter S, Nash RJ, Evinson EL, Fleet GWJ, 'Hydroxymethyl-Branched Piperidines from Hydroxymethyl-Branched Lactones: Synthesis and Biological Evaluation of 1,5-Dideoxy-2-C-hydroxymethyl-1,5-imino-D-mannitol, 1,5-Dideoxy-2-C-hydroxymethyl-1,5-imino-L-gulitol and 1,5-Dideoxy-2-C-hydroxymethyl-1,5-imino-D-talitol', EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2394-2402 (2012) [C1]
DOI10.1002/ejoc.201200054Author URL
CitationsScopus - 11Web of Science - 8
2012Jenkinson SF, Thompson AL, Simone MI, 'Methyl 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-4-nitrobenzoate', Acta Crystallographica Section E: Structure Reports Online, 68 o2429-o2430 (2012) [C1]
DOI10.1107/S1600536812029650
2012Gooding M, Tudzarova S, Worthington RJ, Kingsbury SR, Rebstock A-S, Dube H, et al., 'Exploring the Interaction Between siRNA and the SMoC Biomolecule Transporters: Implications for Small Molecule-Mediated Delivery of siRNA', CHEMICAL BIOLOGY & DRUG DESIGN, 79 9-21 (2012)
DOI10.1111/j.1747-0285.2011.01249.xAuthor URL
CitationsScopus - 3Web of Science - 3
2011Simone MI, Edwards AA, Tranter GE, Fleet GWJ, 'C-3 branched delta-3,5-cis- and trans-THF sugar amino acids: synthesis of the first generation of branched homooligomers', AMINO ACIDS, 41 643-661 (2011) [C1]
DOI10.1007/s00726-011-0849-7Author URL
CitationsScopus - 8Web of Science - 7
2010Simone MI, Edwards AA, Parker SG, Tranter GE, Fleet GWJ, Watkin DJ, 'Pentafluorophenyl (3R,4R,5S)-5-{[(3R,4R,5S)-5-azidomethyl-3,4-dimethoxy-2,3,4,5-tetrahydrofuran-3-carboxamido] methyl}-3,4-dimethoxy-2,3,4,5-tetrahydrofuran-3-carboxylate', ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 66 O2699-U1584 (2010) [C1]
DOI10.1107/S1600536810038559Author URL
CitationsScopus - 2Web of Science - 2
2010Simone MI, Edwards AA, Cowley AR, Fleet GWJ, Watkin DJ, '(3R,4R,5R)-5-(Acetamidomethyl)-N-benzyl-3,4-dihydroxytetrahydrofuran-3-carboxamide', ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 66 O2750-U2003 (2010) [C1]
DOI10.1107/S1600536810039589Author URL
CitationsScopus - 1Web of Science - 1
2009Hobbs AJ, Gane P, Lumsden N, Nobles M, Rebstock A-S, Simone M, et al., 'Design and development of novel non-peptide agonists at natriuretic peptide receptor-C', FASEB JOURNAL, 23 (2009) [E3]
Author URL
2008Simone MI, Edwards AA, Tranter GE, Fleet GWJ, 'Carbon-branched delta-tetrahydrofuran sugar amino acids (SAAs) as dipeptide isostere scaffolds', TETRAHEDRON-ASYMMETRY, 19 2887-2894 (2008) [C1]
DOI10.1016/j.tetasy.2008.12.012Author URL
CitationsScopus - 18Web of Science - 19
2007Risseeuw MDP, Overhand M, Fleet GWJ, Simone MI, 'A compendium of sugar amino acids (SAA): scaffolds, peptide- and glyco-mimetics', TETRAHEDRON-ASYMMETRY, 18 2001-2010 (2007)
DOI10.1016/j.tetasy.2007.08.004Author URL
CitationsScopus - 62Web of Science - 67
2007Simone M, Fleet GWJ, Watkin DJ, '3,3': 5,6-Di-O-isopropylidene-3-C-hydroxy-methyl-(D)-allono-1,4-lactone: an organic structure containing large unoccupied voids', ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 63 O799-O801 (2007)
DOI10.1107/S1600536807002061Author URL
CitationsScopus - 6Web of Science - 6
2007Simone M, Fleet GWJ, Watkin DJ, '1,5-Anhydro-2,3-O-isopropylidene-L-lyxo-furanose [(1S,4S,5S,6R)-5,6-O-isopropylidene-2,7-dioxabicyclo[2.2.1]heptane-5,6-diol]', ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 63 O896-O897 (2007)
DOI10.1107/S160053680700311XAuthor URL
CitationsScopus - 1Web of Science - 1
2007Simone M, Fleet GWJ, Watkin DJ, '5-O-tert-butyldiphenylsilyl-2-C-hydroxymethyl-2,3-O-isopropylidene-2 ' O-trifluoromethanesulfonyl-D-ribono-1,4-lactone', ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 63 o1088-o1090 (2007)
DOI10.1107/S1600536807004436Author URL
2007Simone M, Fleet GWJ, Bream R, Watkin DJ, '5-Amino-5-deoxy-2-C-hydroxymethyl-2,3-O-iso-propylidene-(L)-lyxono-1,5-lactam', ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 63 o1409-o1411 (2007)
DOI10.1107/S1600536807007568Author URL
CitationsScopus - 2Web of Science - 2
2006Bleriot Y, Simone MI, Wormald MR, Dwek RA, Watkin DJ, Fleet GWJ, 'Sugar amino acids at the anomeric position of carbohydrates: synthesis of spirocyclic amino acids of 6-deoxy-L-lyxofuranose', TETRAHEDRON-ASYMMETRY, 17 2276-2286 (2006)
DOI10.1016/j.tetasy.2006.07.027Author URL
CitationsScopus - 20Web of Science - 20
2006Punzo F, Cowley AR, Watkin DJ, Simone MI, Edwards AA, Tranter GE, Fleet GWJ, 'Pentafluorophenyl (3R,4R,5R)-5-{[(3R,4R,5R)-5-azidomethyl-3,4-dimethoxy-2,3,4,5-tetrahydro-furan-3-carbonylamino]methyl}-3,4-dimethoxy-2,3,4,5-tetrahydrofuran-3-carboxylate', ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 62 O473-O475 (2006)
DOI10.1107/S1600536805043205Author URL
CitationsScopus - 4Web of Science - 3
2006Parker SG, Watkin DJ, Simone MI, Fleet GWJ, '3,4 : 5,6-di-O-isopropylidene-3-C-hydroxy-methyl-D-altrono-1,3 '-lactone', ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 62 O3961-O3963 (2006)
DOI10.1107/S1600536806015881Author URL
CitationsScopus - 10Web of Science - 10
2006Jockusch RA, Talbot FO, Rogers PS, Simone MI, Fleet GWJ, Simons JP, 'Carbohydrate amino acids: The intrinsic conformational preference for a beta-turn-type structure in a carbopeptoid building block', JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 128 16771-16777 (2006)
DOI10.1021/ja0607133Author URL
CitationsWeb of Science - 21
2005Punzo F, Watkin DJ, Simone MI, Fleet GWJ, '(3R,4R,5S)-5-(acetamidomethyl)-N-benzyl-3,4-dihydroxytetrahydrofuran-3-carboxamide', ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 61 O513-O515 (2005)
DOI10.1107/S1600536805001467Author URL
CitationsScopus - 2Web of Science - 2
2005Soengas R, Izumori K, Simone MI, Watkin DJ, Skytte UP, Soetaert W, Fleet GWJ, 'Kiliani reactions on ketoses: branched carbohydrate building blocks from D-tagatose and D-psicose', TETRAHEDRON LETTERS, 46 5755-5759 (2005)
DOI10.1016/j.tetlet.2005.06.030Author URL
CitationsScopus - 45Web of Science - 49
2005Simone MI, Soengas R, Newton CR, Watkin DJ, Fleet GWJ, 'Branched tetrahydrofuran alpha,alpha-disubstituted-delta-sugar amino acid scaffolds from branched sugar lactones: a new family of foldamers?', TETRAHEDRON LETTERS, 46 5761-5765 (2005)
DOI10.1016/j.tetlet.2005.06.029Author URL
CitationsScopus - 30Web of Science - 29
2004Hotchkiss D, Soengas R, Simone MI, van Ameijde J, Hunter S, Cowley AR, Fleet GWJ, 'Kiliani on ketoses: branched carbohydrate building blocks from D-fructose and L-sorbose', TETRAHEDRON LETTERS, 45 9461-9464 (2004)
DOI10.1016/j.tetlet.2004.10.086Author URL
CitationsScopus - 52Web of Science - 52
2004Watkins DJ, Muller M, Bleriot Y, Simone MI, Fleet GWJ, '(2S,3R,4R,5S)-3,4-O-isopropylidene-2-methyl-1-oxa-6,9-diazaspiro[4.5]decane-7,10-dione', ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 60 O1820-O1822 (2004)
DOI10.1107/S1600536804022494Author URL
CitationsScopus - 2Web of Science - 2
2004van Ameijde J, Cowley AR, Fleet GWJ, Nash RJ, Simone MI, Soengas R, '5-amino-5-deoxy-2-C-hydroxymethyl-2,3-O-isopropylidene-D-talono-1,5-lactam', ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 60 O2140-O2141 (2004)
DOI10.1107/S1600536804025292Author URL
CitationsScopus - 9Web of Science - 4
2004Cowley AR, Fleet GWJ, Simone MI, Soengas R, '3-O-tert-butyldimethylsilyl-2,2 ': 5,6-di-O-isopropylidene-2-C-hydroxymethyl-D-1,4-gluconolactone', ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 60 O2142-O2143 (2004)
DOI10.1107/S1600536804025310Author URL
CitationsScopus - 5Web of Science - 5
2004Punzo F, Watkin DJ, Simone MI, Fleet GWJ, '(1R,5S,8R)-1,8-dihydroxy-6-oxa-3-azabicyclo[3.2.1]octan-2-one', ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 60 O2315-O2317 (2004)
DOI10.1107/S1600536804028983Author URL
CitationsWeb of Science - 3
2004Newton CR, Michela IS, Fleet GWJ, Blériot Y, Watkin DJ, '2- -Hydroxymethyl-2,3- -isopropylidene- -ribono-1,5-lactam', Acta Crystallographica Section E Structure Reports Online, 60 o909-o910 (2004)
DOI10.1107/S1600536804008141
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Conference (2 outputs)

YearCitationAltmetricsLink
2005Simone M, 'Branched sugar amino acids as foldamers', ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Washington, DC (2005)
Author URL
2005Edwards AA, Fleet GWJ, Mayes BA, Hunterz SJ, Soengas RG, Simone M, Tranter GE, 'Chiroptical spectroscopy and sugar amino acid systems', ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Washington, DC (2005)
Author URL

Patent (1 outputs)

YearCitationAltmetricsLink
2012Simone M, Selwood D, et al, GUANIDINO-SUBSTITUTED BI-AND POLYPHENYLS AS SMALL MOLECULE CARRIERS (2012)
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Research Supervision

Current Supervision

CommencedResearch Title / Program / Supervisor Type
2015Applications of Flow Chemistry to the Synthesis of Novel Classes of Iminosugars
Chemical Sciences, Faculty of Science and Information Technology
Principal Supervisor
2015Applications of Flow Chemistry to the Synthesis of Novel Classes of Iminosugars
Chemical Sciences, Faculty of Science and Information Technology
Principal Supervisor
2015Applications of Flow Chemistry to the Synthesis of Novel Classes of Iminosugars
Chemical Sciences, Faculty of Science and Information Technology
Principal Supervisor
2014Novel Classes of Iminosugars as Glycosidase Inhibitors via a Flow Chemistry Approach
Chemical Sciences, Faculty of Science and Information Technology
Principal Supervisor
2011Synthesis of Bolinaquinone Analogues as Clathrin Mediated Endocytosis
Chemical Sciences, Faculty of Science and Information Technology
Co-Supervisor
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Dr Michela Simone

Position

Lecturer
School of Environmental and Life Sciences
Faculty of Science and Information Technology

Contact Details

Emailmichela.simone@newcastle.edu.au
Phone(02) 4985 4037
Fax(02) 4921 5361

Office

RoomC324
BuildingChemistry
LocationCallaghan
University Drive
Callaghan, NSW 2308
Australia
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