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Professor Mark Parsons

National Heart Foundation Fellow and Brawn Career Development Fellow

School of Medicine and Public Health

Career Summary

Biography

A/Prof Parsons is a post-doctoral researcher, whose work using magnetic resonance and CT imaging techniques to study stroke pathophysiology and new therapeutic approaches is internationally recognised. He has published a number of first author papers in prestigious international journals, three of which have been keynote publications in the high impact Annals of Neurology, each accompanied by an editorial. A/Prof. Parsons PhD thesis detailed the use of modern, multimodality MRI techniques in acute stroke, from which he published several first author papers in high-impact international journals. He had particular interests in the effects of thrombolysis on the ischaemic penumbra, showing that intravenous tPA salvaged significant brain tissue in this critical region and these benefits correlated with improved clinical outcomes. A/Prof. Parsons has also demonstrated the ability to translate fundamental research in the laboratory and clinic into solutions with direct practical application that can be incorporated into clinical practice. He has experience in the re-design and evaluation of health systems, often a critical step in the implementation of complex therapies such as stroke thrombolysis. A/Prof Parsons led the development of an ambulance protocol in the Hunter Region for the rapid identification, pre-hospital notification, and rapid transport of potential thrombolysis patients to a specialist stroke centre. This protocol led to a substantial increase in patients treated with thrombolytic therapy in the Hunter and on the Central Coast.

Research Expertise
1. Low-dose Tenecteplase versus standard dose alteplase: An imaging based efficacy trial 2. Experimental model to investigate CT brain perfusion 3. A functional MRI study of early upper limb therapy in Acute Stroke 4. Supplementary oxygen for acute ischaemic stroke: an imaging-based efficacy trial (SOS trial) 5. The Third International Stroke Trial (IST-3) 6. Imaging the ischaemic penumbra with perfusion CT 7. Genetics and stroke – the role of genetic variations in tPA and PAI-1 in stroke occurrence and severity 8. Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET) The pilot phase was a component of PhD research. Study co-ordinator of this multi-centre Australasian trial. 9. Diabetes and stroke outcome (functional disability, depression, and cognition) 10. Hypothermia in acute stroke INNERCOOL safety study 11. Monitoring of stroke thrombolysis with continuous transcranial Doppler ultrasound 12. Comparison of CT angiography with transcranial colour coded duplex ultrasound for extra- and intra-cranial vascular stenosis 13. Constraint-induced therapy for stroke recovery This study is investigating the use of constraint for the non-hemiplegic upper limb to aid recovery of the affected upper limb in stroke patients 14. Investigator, John Hunter Hospital in Current Stroke Trials • INNERCOOL Safety Study – Cooling for Acute Ischemic Brain Damage – Radiant Medical • SAINT neuroprotective study • Repinotan neuroprotective study • VITATOPS – vitamins to prevent recurrent stroke • PROFESS – secondary stroke prevention 15. Investigator, RMH in Completed Stroke Trials • Cool-Aid Safety Study – Cooling for Acute Ischemic Brain Damage – Radiant Medical • Novo VII (Novo Nordisk) Stroke Trial F7ICH-1389 - Quintiles • IMAGES (Intravenous Magnesium Efficacy in Stroke) • CHARISMA Secondary Stroke Prevention – Sanofi/BMS • ON TARGET Secondary Stroke Prevention – Bohringher Ingelheim • DIAS – Desmotoplase in acute stroke • Pfizer 256, 301 - Trial in ischaemic and haemorrhagic strokes; • BMS 204352 – A double blind, placebo-controlled, safety, efficacy and dose response trial of two intravenous doses in patients with acute stroke. • SPARCL – A double-blind, randomised, placebo-controlled study of atorvastatin as prevention of cerebrovascular events in patients with previous transient ischemic attack (TIA) or Stroke

Teaching Expertise
• Lecturer and clinical teaching (2003-), John Hunter and Newcastle Mater Hospital FRACP Basic Trainees. • Lectures, tutorials and bedside teaching (2003-), Year 2-5 Medical Students, Faculty of Health, University of Newcastle. • Lectures, tutorials and clinical teaching (1999-2002), 2nd Year Neuroscience Course, 4th and Final Year Medical Students (The Royal Melbourne Hospital, Faculty of Medicine, University of Melbourne). • Lecturer and clinical teaching (1999-2002), RMH FRACP Basic Trainees in Neurology. • Lecturer (1999-2002), Victorian Advanced Trainees in Neurology education programme • Lecturer (1999-2002), RMH Postgraduate Nursing Neuroscience Certificate Course. • Professional skills tutor (1994-1998, 2003-), University of Newcastle Medical School. • Neurology Clinical Tutor (1996-1998, 2003-), University of Newcastle Medical School. • Clinical Tutor (1995 – 1998, 2003-), Psychiatry Trainees for the “Medicine in Psychiatry” FRANZP examinations.

Administrative Expertise
• Vice President Stroke Society of Australasia, 2010- • Member NHMRC Grant Review Panel, 2006, 2010, 2011. • Member, University of Newcastle Early Career Fellowships Selection Committee, 2011- • Member, University of Newcastle Research Council, 2010- • Chairman NHMRC NICS Stroke Care Bundle Implementation Committee, 2010- • Director, University of Newcastle Priority Research Centre for Brain and Mental Health, Stroke Research Program, 2008- • Chairman, Australasian Stroke Trials Network, 2007-2010. • Chairman, NSW Stroke CT Working Party, 2006- • Chairman, John Hunter Hospital Quality Use of Medicines Committee, 2005- • Chairman, Hunter New England Area Human Research Ethics Committee, 2005- • Medical Representative, Newcastle Mater Hospital OH&S Committee, 2004- • National Coordinator, Safe Implementation of Thrombolysis for Stroke (SITS) International Registry, 2003- • Director of Stroke Unit, Newcastle Mater Misericordiae Hospital, 2003- • Member, Hunter Area Research and Ethics Committee, 2003- • Medical Representative, Occupational Health and Safety Committee, Newcastle Mater Misericordiae Hospital, 2003- • Head, Neurology Outpatients Clinic, Royal Melbourne Hospital, 2001-2002 • Stroke Care Unit Organisation Committee, Royal Melbourne Hospital, 2000-2001. • National Stroke Foundation Representative, National Heart Foundation Lipid Guidelines Committee (2000-2001). • Senior Medical Registrar, Mater Misericordiae Hospital, 1996. • Advanced Trainee Representative, Hunter and Northern Society of Physicians (HANSOP) Committee, 1996-1998.

Collaborations
He is a CI on a current NHMRC program grant - ‘Improving Stroke Outcomes: Attenuating Progression and Recurrence’. He is CIA on a current NHMRC patnership grant, relating to standardization and implantation of advanced CT imaging in acute stroke. He is on the Steering Committees of multi-centre stroke trials EXTEND and INTERACTII (and a CI on the NHRMC project grant for INTERACTII. A/Prof. Parsons has completed two NHMRC-funded projects as principal investigator. The first investigated CT perfusion in acute ischaemic stroke and provided the impetus to establish an internationally unique human stroke perfusion imaging library of over 400 patients. The project directly led to six original articles, and one invited review, which have been published in international peer-reviewed journals. The second was a multi-centre study (2008-2010) of a new thrombolytic agent tenecteplase versus the standard agent alteplase in acute stroke. This study used CT perfusion both for patient selection into the trial, and also to compare reperfusion and penumbral salvage between the two agents. Articles resulting from this study have been published in The New England Journal of Medicine, Brain, Stroke, and Neurology. On projects related to stroke imaging, A/Prof. Parsons is currently supervising three PhD Students (with two more PhD students recently completing, one post-doctoral student, one B Med Sci student, and a Clinical Stroke Fellow. A/Prof. Parsons established the Stroke Imaging Research Laboratory at John Hunter Hospital, and is Director of the University of Newcastle’s Stroke Research Program, which is one of the four major streams of the Translational Neuroscience and Mental Health Priority Research Centre. He is the current vice-President Stroke Society of Australasia and is the immediate past chairman of the Australasian Stroke Trials Network.


Qualifications

  • Doctor of Philosophy, University of Melbourne
  • Bachelor of Medicine, University of Newcastle

Keywords

  • Bedside Teaching
  • • Cerebral blood flow and metabolism
  • • Cerebrovascular disease
  • • Clinical Tutor
  • • Functional brain imaging techniques in stroke
  • • Lecturer
  • • Neurological education
  • • Neurological rehabilitation and brain recovery
  • • Neurology Clinical Tutor

Fields of Research

CodeDescriptionPercentage
111799Public Health and Health Services not elsewhere classified25
110399Clinical Sciences not elsewhere classified30
110999Neurosciences not elsewhere classified45

Professional Experience

UON Appointment

DatesTitleOrganisation / Department
15/02/2014 - ProfessorUniversity of Newcastle
School of Medicine and Public Health
Australia

Academic appointment

DatesTitleOrganisation / Department
1/03/2010 - 1/02/2014Fellow ARC
ARC - Discovery - Future Fellowships
University of Newcastle
School of Medicine and Public Health
Australia
1/01/2006 - Current ChairmanHunter and New England Area Human Research Ethics Committee
Australia

Awards

Recipient

YearAward
2004For excellence in Brain and Mental Health research
Hunter Medical Research Institute
2002Young Investigator
Stroke Society of Australasia

Invitations

Participant

YearTitle / Rationale
2006Keynote Speaker on stroke imaging
Organisation: National and International meetings
Edit

Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Chapter (4 outputs)

YearCitationAltmetricsLink
2013Bivard A, Stanwell P, Parsons M, 'Stroke and Cerebral Ischemia', Magnetic Resonance Spectroscopy: Tools for Neuroscience Research and Emerging Clinical Applications, Elsevier Inc. 183-195 (2013) [B2]

Stroke is the leading cause of adult disability in the developed world. Advanced imaging techniques such as magnetic resonance spectroscopy (MRS) allow noninvasive measurements of brain metabolite concentrations that may be useful in the future. Currently, MRS is not generally used in clinical stroke MR exams, particularly due to the time-sensitive nature of acute treatments. However, MRS holds a great deal of promise for research in trying to understand some of the underlying mechanisms behind stroke recovery and as a means to identify potential treatment targets to enhance rehabilitation. © 2014 Elsevier Inc. All rights reserved.

DOI10.1016/B978-0-12-401688-0.00014-8
2006Parsons MW, Davis SM, 'The Therapeutic Impact of MRI in Acute Stroke', Magnetic Resonance Imaging in Ischemic Stroke, Springer, Berlin 23-40 (2006) [B1]
2002Parsons MW, 'MRI and Other Neuroimaging for Subcortical Stroke', , Oxford Medical Publications (2002) [B1]
2002Parsons MW, 'Clinical role of echoplanar MRI in stroke', , Cambridge Press (2002) [B1]
Show 1 more chapter

Journal article (162 outputs)

YearCitationAltmetricsLink
2015Tu HT, Campbell BC, Christensen S, Desmond PM, De Silva DA, Parsons MW, et al., 'Worse stroke outcome in atrial fibrillation is explained by more severe hypoperfusion, infarct growth, and hemorrhagic transformation.', Int J Stroke, 10 534-540 (2015)
DOI10.1111/ijs.12007Author URL
2015Arima H, Heeley E, Delcourt C, Hirakawa Y, Wang X, Woodward M, et al., 'Optimal achieved blood pressure in acute intracerebral hemorrhage INTERACT2', NEUROLOGY, 84 464-471 (2015)
DOI10.1212/WNL.0000000000001205Author URL
CitationsWeb of Science - 2
2015Campbell BCV, Mitchell PJ, Kleinig TJ, Dewey HM, Churilov L, Yassi N, et al., 'Endovascular therapy for ischemic stroke with perfusion-imaging selection', New England Journal of Medicine, 372 1009-1018 (2015)

Background: Trials of endovascular therapy for ischemic stroke have produced variable results. We conducted this study to test whether more advanced imaging selection, recently developed devices, and earlier intervention improve outcomes. Methods: We randomly assigned patients with ischemic stroke who were receiving 0.9 mg of alteplase per kilogram of body weight less than 4.5 hours after the onset of ischemic stroke either to undergo endovascular thrombectomy with the Solitaire FR (Flow Restoration) stent retriever or to continue receiving alteplase alone. All the patients had occlusion of the internal carotid or middle cerebral artery and evidence of salvageable brain tissue and ischemic core of less than 70 ml on computed tomographic (CT) perfusion imaging. The coprimary outcomes were reperfusion at 24 hours and early neurologic improvement (.8-point reduction on the National Institutes of Health Stroke Scale or a score of 0 or 1 at day 3). Secondary outcomes included the functional score on the modified Rankin scale at 90 days. Results: The trial was stopped early because of efficacy after 70 patients had undergone randomization (35 patients in each group). The percentage of ischemic territory that had undergone reperfusion at 24 hours was greater in the endovascular-therapy group than in the alteplase-only group (median, 100% vs. 37%; P<0.001). Endovascular therapy, initiated at a median of 210 minutes after the onset of stroke, increased early neurologic improvement at 3 days (80% vs. 37%, P = 0.002) and improved the functional outcome at 90 days, with more patients achieving functional independence (score of 0 to 2 on the modified Rankin scale, 71% vs. 40%; P = 0.01). There were no significant differences in rates of death or symptomatic intracerebral hemorrhage. Conclusions: In patients with ischemic stroke with a proximal cerebral arterial occlusion and salvageable tissue on CT perfusion imaging, early thrombectomy with the Solitaire FR stent retriever, as compared with alteplase alone, improved reperfusion, early neurologic recovery, and functional outcome. (Funded by the Australian National Health and Medical Research Council and others; EXTEND-IA ClinicalTrials.gov number, NCT01492725, and Australian New Zealand Clinical Trials Registry number, ACTRN12611000969965.)

DOI10.1056/NEJMoa1414792
CitationsScopus - 33Web of Science - 29
Co-authorsChris Levi
2015Marquez J, van Vliet P, Mcelduff P, Lagopoulos J, Parsons M, 'Transcranial direct current stimulation (tDCS): Does it have merit in stroke rehabilitation? A systematic review', International Journal of Stroke, 10 306-316 (2015)

Transcranial direct current stimulation has been gaining increasing interest as a potential therapeutic treatment in stroke recovery. We performed a systematic review with meta-analysis of randomized controlled trials to collate the available evidence in adults with residual motor impairments as a result of stroke. The primary outcome was change in motor function or impairment as a result of transcranial direct current stimulation, using any reported electrode montage, with or without adjunct physical therapy. The search yielded 15 relevant studies comprising 315 subjects. Compared with sham, cortical stimulation did not produce statistically significant improvements in motor performance when measured immediately after the intervention (anodal stimulation: facilitation of the affected cortex: standardized mean difference=0·05, P=0·71; cathodal stimulation: inhibition of the nonaffected cortex: standardized mean difference=0·39, P=0·08; bihemispheric stimulation: standardized mean difference=0·24, P=0·39). When the data were analyzed according to stroke characteristics, statistically significant improvements were evident for those with chronic stroke (standardized mean difference=0·45, P=0·01) and subjects with mild-to-moderate stroke impairments (standardized mean difference=0·37, P=0·02). Transcranial direct current stimulation is likely to be effective in enhancing motor performance in the short term when applied selectively to patients with stroke. Given the range of stimulation variables and heterogeneous nature of stroke, this modality is still experimental and further research is required to determine its clinical merit in stroke rehabilitation.

DOI10.1111/ijs.12169
CitationsScopus - 3Web of Science - 1
Co-authorsJodie Marquez, Paulette Vanvliet
2015Campbell BCV, Yassi N, Ma H, Sharma G, Salinas S, Churilov L, et al., 'Imaging selection in ischemic stroke: Feasibility of automated CT-perfusion analysis', International Journal of Stroke, 10 51-54 (2015)

Background: Advanced imaging may refine patient selection for ischemic stroke treatment but delays to acquire and process the imaging have limited implementation. Aims: We examined the feasibility of imaging selection in clinical practice using fully automated software in the EXTEND trial program. Methods: CTP and perfusion-diffusion MRI data were processed using fully-automated software to generate a yes/no 'mismatch' classification that determined eligibility for trial therapies. The technical failure/mismatch classification error rate and time to image and treat with CT vs. MR-based selection were examined. Results: In a consecutive series of 776 patients from five sites over six-months the technical failure rate of CTP acquisition/processing (uninterpretable maps) was 3·4% (26/776, 95%CI 2·2-4·9%). Mismatch classification was overruled by expert review in an additional 9·0% (70/776, 95%CI 7·1-11·3%) due to artifactual 'perfusion lesion'. In 154 consecutive patients at one site, median additional time to acquire CTP after non-contrast CT was 6·5min. Subsequent RAPID processing time varied from 3-10min across 20 trial centers (median 5min 20s). In the EXTEND trial, door-to-needle times in patients randomized on the basis of CTP (n=47) were median 78min shorter than MRI-selected (n=16) patients (P<0·001). Conclusions: Automated CTP-based mismatch selection is rapid, robust in clinical practice, and associated with faster treatment decisions than MRI. This technological advance has the potential to improve the standardization and reproducibility of interpretation of advanced imaging and extend use to practice settings beyond highly specialized academic centers.

DOI10.1111/ijs.12381
CitationsScopus - 2Web of Science - 3
2015Campbell BCV, Parsons MW, 'Repeat brain imaging after thrombolysis is important', International Journal of Stroke, 10 E18-E18 (2015)
DOI10.1111/ijs.12412
2015Hubbard IJ, Carey LM, Budd TW, Parsons MW, 'Reorganizing therapy: changing the clinical approach to upper limb recovery post-stroke.', Occup Ther Int, 22 28-35 (2015)
DOI10.1002/oti.1381Author URL
Co-authorsBill Budd, Isobel Hubbard
2015Marquez J, van Vliet P, Mcelduff P, Lagopoulos J, Parsons M, 'Transcranial direct current stimulation (tDCS): Does it have merit in stroke rehabilitation? A systematic review', International Journal of Stroke, 10 306-316 (2015)

Transcranial direct current stimulation has been gaining increasing interest as a potential therapeutic treatment in stroke recovery. We performed a systematic review with meta-analysis of randomized controlled trials to collate the available evidence in adults with residual motor impairments as a result of stroke. The primary outcome was change in motor function or impairment as a result of transcranial direct current stimulation, using any reported electrode montage, with or without adjunct physical therapy. The search yielded 15 relevant studies comprising 315 subjects. Compared with sham, cortical stimulation did not produce statistically significant improvements in motor performance when measured immediately after the intervention (anodal stimulation: facilitation of the affected cortex: standardized mean difference=0·05, P=0·71; cathodal stimulation: inhibition of the nonaffected cortex: standardized mean difference=0·39, P=0·08; bihemispheric stimulation: standardized mean difference=0·24, P=0·39). When the data were analyzed according to stroke characteristics, statistically significant improvements were evident for those with chronic stroke (standardized mean difference=0·45, P=0·01) and subjects with mild-to-moderate stroke impairments (standardized mean difference=0·37, P=0·02). Transcranial direct current stimulation is likely to be effective in enhancing motor performance in the short term when applied selectively to patients with stroke. Given the range of stimulation variables and heterogeneous nature of stroke, this modality is still experimental and further research is required to determine its clinical merit in stroke rehabilitation.

DOI10.1111/ijs.12169
CitationsScopus - 1
Co-authorsPaulette Vanvliet, Jodie Marquez
2015Zhang S, Tang H, Yu Y-N, Yan S-Q, Parsons MW, Lou M, 'Optimal Magnetic Resonance Perfusion Thresholds Identifying Ischemic Penumbra and Infarct Core: A Chinese Population-based Study', CNS NEUROSCIENCE & THERAPEUTICS, 21 289-295 (2015)
DOI10.1111/cns.12367Author URL
2015Zhang S, Tang H, Yu Y-N, Yan S-Q, Parsons MW, Lou M, 'Optimal Magnetic Resonance Perfusion Thresholds Identifying Ischemic Penumbra and Infarct Core: A Chinese Population-based Study', CNS Neuroscience and Therapeutics, 21 289-295 (2015)

Summary: Aims: To validate whether the optimal magnetic resonance perfusion (MRP) thresholds for ischemic penumbra and infarct core, between voxel and volume-based analysis, are varied greatly among Chinese acute ischemic stroke patients. Materials and methods: Acute ischemic stroke patients receiving intravenous thrombolysis within 6 h of onset that obtained acute and 24-h MRP were reviewed. Patients with either no reperfusion (<30% reperfusion at 24 h) or successful reperfusion (>70% reperfusion at 24 h) were enrolled to investigate the ischemic penumbra and infarct core, respectively. The final infarct was assessed on 24-h diffusion-weighted imaging (DWI), which was retrospectively matched to the baseline perfusion-weighted imaging (PWI) images by volume or voxel-based analysis. The optimal thresholds that determined by each approach were compared. Results: From June 2009 to Jan 2014, of 50 patients enrolled, 19 patients achieved no reperfusion, and 20 patients reperfused at 24 h. In patients with no reperfusion, Tmax > 6 seconds was proved of the best agreement with the final infarct in both volumetric analysis (ratio: 1.05, 95% limits of agreement:-0.23 to 2.33, P < 0.001) and voxel-by-voxel analysis (sensitivity: 72.3%, specificity: 74.3%). In patients with reperfusion, rMTT>225% (ratio:2.4, 95% limits of agreement: -6.5 to 11.4, P < 0.001) was found of the best volumetric agreement with the final infarct, while Tmax > 5.6 seconds (sensitivity: 76.8%, specificity: 70.3%) performed most accurately in voxel-based analysis. Conclusion: Among Chinese acute stroke patients, volume of Tmax >6 seconds may precisely target ischemic penumbra tissue as good as voxel-based analysis performed, albeit no concordant MRP parameter is found to accurately predict infarct core because reperfusion occurred within 24 h after thrombolysis fails to restrain the infarct growth.

DOI10.1111/cns.12367
2014Paul CL, Levi CR, D'Este CA, Parsons MW, Bladin CF, Lindley RI, et al., 'Thrombolysis ImPlementation in Stroke (TIPS): Evaluating the effectiveness of a strategy to increase the adoption of best evidence practice - protocol for a cluster randomised controlled trial in acute stroke care', Implementation Science, 9 (2014) [C3]

Background: Stroke is a leading cause of death and disability internationally. One of the three effective interventions in the acute phase of stroke care is thrombolytic therapy with tissue plasminogen activator (tPA), if given within 4.5 hours of onset to appropriate cases of ischaemic stroke.Objectives: To test the effectiveness of a multi-component multidisciplinary collaborative approach compared to usual care as a strategy for increasing thrombolysis rates for all stroke patients at intervention hospitals, while maintaining accepted benchmarks for low rates of intracranial haemorrhage and high rates of functional outcomes for both groups at three months.Methods and design: A cluster randomised controlled trial of 20 hospitals across 3 Australian states with 2 groups: multi- component multidisciplinary collaborative intervention as the experimental group and usual care as the control group. The intervention is based on behavioural theory and analysis of the steps, roles and barriers relating to rapid assessment for thrombolysis eligibility; it involves a comprehensive range of strategies addressing individual-level and system-level change at each site. The primary outcome is the difference in tPA rates between the two groups post-intervention. The secondary outcome is the proportion of tPA treated patients in both groups with good functional outcomes (modified Rankin Score (mRS <2) and the proportion with intracranial haemorrhage (mRS =2), compared to international benchmarks.Discussion: TIPS will trial a comprehensive, multi-component and multidisciplinary collaborative approach to improving thrombolysis rates at multiple sites. The trial has the potential to identify methods for optimal care which can be implemented for stroke patients during the acute phase. Study findings will include barriers and solutions to effective thrombolysis implementation and trial outcomes will be published whether significant or not.Trial registration: Australian New Zealand Clinical Trials Registry: ACTRN12613000939796. © 2014 Paul et al.; licensee BioMed Central Ltd.

DOI10.1186/1748-5908-9-38
CitationsWeb of Science - 1
Co-authorsJohn Attia, Chris Paul, Catherine Deste, Rob Sanson-Fisher, Chris Levi, Frans Henskens
2014Hubbard IJ, Carey LM, Budd TW, Levi C, McElduff P, Hudson S, et al., 'A Randomized Controlled Trial of the Effect of Early Upper-Limb Training on Stroke Recovery and Brain Activation.', Neurorehabil Neural Repair, (2014)
DOI10.1177/1545968314562647Author URL
Co-authorsIsobel Hubbard, Bill Budd
2014Bivard A, Krishnamurthy V, Stanwell P, Levi C, Spratt NJ, Davis S, Parsons M, 'Arterial Spin Labeling Versus Bolus-Tracking Perfusion in Hyperacute Stroke', Stroke, 45 127-133 (2014)
DOI10.1161/STROKEAHA.113.003218Author URL
Co-authorsNeil Spratt, Chris Levi
2014Hubbard IJ, Evans M, McMullen-Roach S, Marquez J, Parsons MW, 'Five years of acute stroke unit care: Comparing ASU and non-ASU admissions and allied health involvement', Stroke Research and Treatment, (2014) [C1]

Background. Evidence indicates that Stroke Units decrease mortality and morbidity. An Acute Stroke Unit (ASU) provides specialised, hyperacute care and thrombolysis. John Hunter Hospital, Australia, admits 500 stroke patients each year and has a 4-bed ASU. Aims. This study investigated hospital admissions over a 5-year period of all strokes patients and of all patients admitted to the 4-bed ASU and the involvement of allied health professionals. Methods. The study retrospectively audited 5-year data from all stroke patients admitted to John Hunter Hospital (n=2525) and from nonstroke patients admitted to the ASU (n=826). The study's primary outcomes were admission rates, length of stay (days), and allied health involvement. Results. Over 5 years, 47% of stroke patients were admitted to the ASU. More male stroke patients were admitted to the ASU (chi2=5.81; P=0.016). There was a trend over time towards parity between the number of stroke and nonstroke patients admitted to the ASU. When compared to those admitted elsewhere, ASU stroke patients had a longer length of stay (z=-8.233; P=0.0000) and were more likely to receive allied healthcare. Conclusion. This is the first study to report 5 years of ASU admissions. Acute Stroke Units may benefit from a review of the healthcare provided to all stroke patients. The trends over time with respect to the utilisation of the John Hunter Hospitall's ASU have resulted in a review of the hospitall's Stroke Unit and allied healthcare. © 2014 Isobel J. Hubbard et al.

DOI10.1155/2014/798258
Co-authorsJodie Marquez, Isobel Hubbard
2014Viscoli CM, Brass LM, Carolei A, Conwit R, Ford GA, Furie KL, et al., 'Pioglitazone for secondary prevention after ischemic stroke and transient ischemic attack: Rationale and design of the Insulin Resistance Intervention after Stroke Trial', American Heart Journal, 168 823-829.e6 (2014)
DOI10.1016/j.ahj.2014.07.016
2014Viscoli CM, Brass LM, Carolei A, Conwit R, Ford GA, Furie KL, et al., 'Pioglitazone for secondary prevention after ischemic stroke and transient ischemic attack: Rationale and design of the Insulin Resistance Intervention after Stroke Trial', American Heart Journal, 168 823-829.e6 (2014) [C3]

Background: Recurrent vascular events remain a major source of morbidity and mortality after stroke or transient ischemic attack (TIA). The IRIS Trial is evaluating an approach to secondary prevention based on the established association between insulin resistance and increased risk for ischemic vascular events. Specifically, IRIS will test the effectiveness of pioglitazone, an insulin-sensitizing drug of the thiazolidinedione class, for reducing the risk for stroke and myocardial infarction (MI) among insulin resistant, nondiabetic patients with a recent ischemic stroke or TIA. Design: Eligible patients for IRIS must have had insulin resistance defined by a Homeostasis Model Assessment-Insulin Resistance >3.0 without meeting criteria for diabetes. Within 6 months of the index stroke or TIA, patients were randomly assigned to pioglitazone (titrated from 15 to 45 mg/d) or matching placebo and followed for up to 5 years. The primary outcome is time to stroke or MI. Secondary outcomes include time to stroke alone, acute coronary syndrome, diabetes, cognitive decline, and all-cause mortality. Enrollment of 3,876 participants from 179 sites in 7 countries was completed in January 2013. Participant follow-up will continue until July 2015. Summary: The IRIS Trial will determine whether treatment with pioglitazone improves cardiovascular outcomes of nondiabetic, insulin-resistant patients with stroke or TIA. Results are expected in early 2016.

DOI10.1016/j.ahj.2014.07.016
2014Goyal M, Almekhlafi M, Menon B, Hill M, Fargen K, Parsons M, et al., 'Challenges of Acute Endovascular Stroke Trials', STROKE, 45 3116-3122 (2014) [C3]
DOI10.1161/STROKEAHA.114.006288Author URL
CitationsWeb of Science - 4
2014Bivard A, Krishnamurthy V, Stanwell P, Levi C, Spratt NJ, Davis S, Parsons M, 'Arterial Spin Labeling Versus Bolus-Tracking Perfusion in Hyperacute Stroke', Stroke, 45 127-133 (2014) [C1]
DOI10.1161/STROKEAHA.113.003218Author URL
CitationsScopus - 4Web of Science - 4
Co-authorsNeil Spratt, Chris Levi
2014Lin L, Bivard A, Levi CR, Parsons MW, 'Comparison of computed tomographic and magnetic resonance perfusion measurements in acute ischemic stroke: Back-to-back quantitative analysis', Stroke, 45 1727-1732 (2014) [C1]

Background and Purpose: Magnetic resonance perfusion (MRP) and computed tomographic perfusion (CTP) are being increasingly applied in acute stroke trials and clinical practice, yet the comparability of their perfusion values is not well validated. The aim of this study was to validate the comparability of CTP and MRP measures. METHODS-: A 3-step approach was used. Step 1 was a derivation step, where we analyzed 45 patients with acute ischemic stroke who had both CTP and MRP performed within 2 hours of each other and within 9 hours of stroke onset. In this step, we derived the optimal perfusion map with the least difference between MRP and CTP. In step 2, the optimal map was validated on whole-brain perfusion data of 15 patients. Step 3 was to apply the optimal perfusion map to define cross-modality reperfusion from acute CTP to 24-hour MRP in 45 patients and, in turn, to assess how accurately this predicted 3-month clinical outcome. RESULTS-: Among 8 different perfusion maps included in this study, time to peak of the residual function (Tmax) was the only one with a nonsignificant difference between CTP and MRP in delineating perfusion defects. This was validated on whole-brain perfusion data, showing high concordance of Tmax between the 2 modalities (concordance correlation coefficient of Lin, >0.91); the best concordance was at 6 s. At T max>6 s threshold, MRP and CTP reached substantial agreement in mismatch classification (¿ >0.61). Cross-modality reperfusion calculated by Tmax>6 s strongly predicted good functional outcome at 3 months (area under the curve, 0.979; P<0.05). CONCLUSIONS-: MRP and CTP can be used interchangeably if one uses Tmax measurement. © 2014 American Heart Association, Inc.

DOI10.1161/STROKEAHA.114.005419
CitationsScopus - 2Web of Science - 3
Co-authorsChris Levi
2014Emberson J, Lees KR, Lyden P, Blackwell L, Albers G, Bluhmki E, et al., 'Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials', LANCET, 384 1929-1935 (2014) [C1]
DOI10.1016/S0140-6736(14)60584-5Author URL
CitationsWeb of Science - 41
2014Bivard A, Levi C, Krishnamurthy V, Hislop-Jambrich J, Salazar P, Jackson B, et al., 'Defining acute ischemic stroke tissue pathophysiology with whole brain CT perfusion', JOURNAL OF NEURORADIOLOGY, 41 307-315 (2014) [C1]
DOI10.1016/j.neurad.2013.11.006Author URL
CitationsScopus - 1Web of Science - 1
Co-authorsChris Levi
2014Bivard A, Krishnamurthy V, Stanwell P, Yassi N, Spratt NJ, Nilsson M, et al., 'Spectroscopy of reperfused tissue after stroke reveals heightened metabolism in patients with good clinical outcomes', JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 34 1944-1950 (2014) [C1]
DOI10.1038/jcbfm.2014.166Author URL
Co-authorsChris Levi, Neil Spratt
2014Gunathilake R, Krishnamurthy V, Oldmeadow C, Kerr E, Padmakumar C, Attia J, et al., 'Relationships between age, other predictive variables, and the 90-day functional outcome after intravenous thrombolysis for acute ischemic stroke', AUSTRALASIAN JOURNAL ON AGEING, 33 19-19 (2014) [E3]
Author URL
Co-authorsChris Levi, John Attia, Christopher Oldmeadow
2014Campbell BCV, Mitchell PJ, Yan B, Parsons MW, Christensen S, Churilov L, et al., 'A multicenter, randomized, controlled study to investigate EXtending the time for Thrombolysis in Emergency Neurological Deficits with Intra-Arterial therapy (EXTEND-IA)', INTERNATIONAL JOURNAL OF STROKE, 9 126-132 (2014) [C3]
DOI10.1111/ijs.12206Author URL
CitationsScopus - 9Web of Science - 8
Co-authorsChris Levi
2014Gunathilake R, Krishnamurthy V, Oldmedow C, Kerr E, Padmakumar C, Attia J, et al., 'Relationships between age, other predictive variables and the 90-day functional outcome after intravenous thrombolysis for acute ischemic stroke', INTERNATIONAL JOURNAL OF STROKE, 9 35-35 (2014)
Author URL
Co-authorsJohn Attia, Chris Levi, Christopher Oldmeadow
2014Picanço MR, Christensen S, Campbell BCV, Churilov L, Parsons MW, Desmond PM, et al., 'Reperfusion after 4·5 hours reduces infarct growth and improves clinical outcomes', International Journal of Stroke, 9 266-269 (2014)
DOI10.1111/ijs.12209
CitationsScopus - 1
Co-authorsChris Levi
2014Picanço MR, Christensen S, Campbell BCV, Churilov L, Parsons MW, Desmond PM, et al., 'Reperfusion after 4·5 hours reduces infarct growth and improves clinical outcomes', International Journal of Stroke, 9 266-269 (2014) [C1]

Background: The currently proven time window for thrombolysis in ischemic stroke is 4·5h. Beyond this, the risks and benefits of thrombolysis are uncertain. Aims: To determine whether thrombolysis and reperfusion were beneficial after 4·5h, we examined clinical and radiological outcomes in patients treated with tissue plasminogen activator or placebo within 4·5-6h, using data from the Echoplanar Imaging Thrombolytic Evaluation Trial. Methods: In the Echoplanar Imaging Thrombolytic Evaluation Trial, ischemic stroke patients presenting three to six-hours after stroke onset were randomized to tissue plasminogen activator or placebo, without knowledge of magnetic resonance imaging results. This analysis was restricted to patients treated between 4·5 and 6h. The effect of tissue plasminogen activator and reperfusion on infarct growth between baseline diffusion-weighted imaging and day 90 T2 imaging was assessed, along with good neurological outcome (=8 point reduction or reaching 0-1 at 90 days on National Institutes of Health Stroke Scale) and functional outcome (modified Rankin scale). The effect of tissue plasminogen activator on reperfusion was also analyzed. Results: Sixty-nine patients were treated 4·5-6h after onset, and infarct growth was assessed in 63. Tissue plasminogen activator was associated with lower relative growth (94% vs. 168%, P=0·03) and a trend to lower absolute growth (-0·17ml versus 9·6ml, P=0·07). Reperfusion was increased in the tissue plasminogen activator group (58% versus 25%, P=0·03) and was associated with increased rates of good neurological (86% versus 28% P<0·001) and functional (modified Rankin scale 0-2 73% versus 34%, P=0·01) outcomes. Reperfusion was strongly associated with lower relative (80% versus 189%, P<0·001) and absolute (-2·5ml versus 40ml, P<0·001) infarct growth. Conclusions: Thrombolysis 4·5-6h after stroke onset reduced infarct growth and increased the rate of reperfusion, which was associated with good neurological and functional outcome. © 2013 World Stroke Organization.

DOI10.1111/ijs.12209
CitationsScopus - 1Web of Science - 1
Co-authorsChris Levi
2014Gunathilake R, Krishnamurthy V, Oldmeadow C, Kerr E, Padmakumar C, Attia J, et al., 'Relationships between age, other predictive variables, and the 90-day functional outcome after intravenous thrombolysis for acute ischemic stroke', International Journal of Stroke, 9 E36-E37 (2014) [O1]
DOI10.1111/ijs.12347
Co-authorsJohn Attia, Chris Levi, Christopher Oldmeadow
2014Tu HTH, Campbell BCV, Christensen S, Desmond PM, De Silva DA, Parsons MW, et al., 'Worse stroke outcome in atrial fibrillation is explained by more severe hypoperfusion, infarct growth, and hemorrhagic transformation', International Journal of Stroke, n/a-n/a (2014)
DOI10.1111/ijs.12007Author URL
2014Meretoja A, Keshtkaran M, Saver JL, Tatlisumak T, Parsons MW, Kaste M, et al., 'Stroke thrombolysis: Save a minute, save a day', Stroke, 45 1053-1058 (2014) [C1]

BACKGROUND AND PURPOSE - : Stroke thrombolysis is highly time-critical, but data on long-term effects of small reductions in treatment delays have not been available. Our objective was to quantify patient lifetime benefits gained from faster treatment. METHODS - : Observational prospective data of consecutive stroke patients treated with intravenous thrombolysis in Australian and Finnish centers (1998-2011; n=2258) provided distributions of age, sex, stroke severity, onset-to-treatment times, and 3-month modified Rankin Scale in daily clinical practice. Treatment effects derived from a pooled analysis of thrombolysis trials were used to model the shift in 3-month modified Rankin Scale distributions with reducing treatment delays, from which we derived the expected lifetime and level of long-term disability with faster treatment. RESULTS - : Each minute of onset-to-treatment time saved granted on average 1.8 days of extra healthy life (95% prediction interval, 0.9-2.7). Benefit was observed in all groups: each minute provided 0.6 day in old severe (age, 80 years; National Institutes of Health Stroke Scale [NIHSS] score, 20) patients, 0.9 day in old mild (age, 80 years; NIHSS score, 4) patients, 2.7 days in young mild (age, 50 years; NIHSS score, 4) patients, and 3.5 days in young severe (age, 50 years; NIHSS score, 20) patients. Women gained slightly more than men over their longer lifetimes. In the whole cohort, each 15 minute decrease in treatment delay provided an average equivalent of 1 month of additional disability-free life. CONCLUSIONS - : Realistically achievable small reductions in stroke thrombolysis delays would result in significant and robust average health benefits over patients' lifetimes. The awareness of concrete importance of speed could promote practice change. © 2014 American Heart Association, Inc.

DOI10.1161/STROKEAHA.113.002910
CitationsScopus - 18Web of Science - 15
2014Clarey J, Lasserson D, Levi C, Parsons M, Dewey H, Barber PA, et al., 'Absolute cardiovascular risk and GP decision making in TIA and minor stroke.', Fam Pract, 31 664-669 (2014) [C1]
DOI10.1093/fampra/cmu054Author URL
Co-authorsChris Levi, Parker Magin
2014Murtha LA, Yang Q, Parsons MW, Levi CR, Beard DJ, Spratt NJ, McLeod DD, 'Cerebrospinal fluid is drained primarily via the spinal canal and olfactory route in young and aged spontaneously hypertensive rats', Fluids and Barriers of the CNS, 11 (2014) [C1]

Background: Many aspects of CSF dynamics are poorly understood due to the difficulties involved in quantification and visualization. In particular, there is debate surrounding the route of CSF drainage. Our aim was to quantify CSF flow, volume, and drainage route dynamics in vivo in young and aged spontaneously hypertensive rats (SHR) using a novel contrast-enhanced computed tomography (CT) method.Methods: ICP was recorded in young (2-5 months) and aged (16 months) SHR. Contrast was administered into the lateral ventricles bilaterally and sequential CT imaging was used to visualize the entire intracranial CSF system and CSF drainage routes. A customized contrast decay software module was used to quantify CSF flow at multiple locations.Results: ICP was significantly higher in aged rats than in young rats (11.52 ± 2.36 mmHg, versus 7.04 ± 2.89 mmHg, p = 0.03). Contrast was observed throughout the entire intracranial CSF system and was seen to enter the spinal canal and cross the cribriform plate into the olfactory mucosa within 9.1 ± 6.1 and 22.2 ± 7.1 minutes, respectively. No contrast was observed adjacent to the sagittal sinus. There were no significant differences between young and aged rats in either contrast distribution times or CSF flow rates. Mean flow rates (combined young and aged) were 3.0 ± 1.5 µL/min at the cerebral aqueduct; 3.5 ± 1.4 µL/min at the 3rd ventric= and 2.8 ± 0.9 µL/min at the 4th ventricle. Intracranial CSF volumes (and as percentage total brain volume) were 204 ± 97 µL (8.8 ± 4.3%) in the young and 275 ± 35 µL (10.8 ± 1.9%) in the aged animals (NS).Conclusions: We have demonstrated a contrast-enhanced CT technique for measuring and visualising CSF dynamics in vivo. These results indicate substantial drainage of CSF via spinal and olfactory routes, but there was little evidence of drainage via sagittal sinus arachnoid granulations in either young or aged animals. The data suggests that spinal and olfactory routes are the primary routes of CSF drainage and that sagittal sinus arachnoid granulations play a minor role, even in aged rats with higher ICP. © 2014 Murtha et al.; licensee BioMed Central Ltd.

DOI10.1186/2045-8118-11-12
CitationsScopus - 4
Co-authorsChris Levi, Neil Spratt, Damian Mcleod
2014Thomas LC, Rivett DA, Parsons M, Levi C, 'Risk factors, radiological features, and infarct topography of craniocervical arterial dissection.', International Journal of Stroke, 9 1073-1082 (2014) [C1]
DOI10.1111/j.1747-4949.2012.00912.xAuthor URL
Co-authorsChris Levi, Lucy Thomas, Darren Rivett
2013Bendinelli C, Bivard A, Nebauer S, Parsons MW, Balogh ZJ, 'Brain CT perfusion provides additional useful information in severe traumatic brain injury', INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED, 44 1208-1212 (2013) [C1]
DOI10.1016/j.injury.2013.03.039Author URL
CitationsScopus - 3Web of Science - 1
Co-authorsZsolt Balogh
2013Campbell BCV, Weir L, Desmond PM, Tu HTH, Hand PJ, Yan B, et al., 'CT perfusion improves diagnostic accuracy and confidence in acute ischaemic stroke', JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 84 613-618 (2013) [C1]
DOI10.1136/jnnp-2012-303752Author URL
CitationsScopus - 10Web of Science - 8
2013Anderson CS, Heeley E, Huang Y, Wang J, Stapf C, Delcourt C, et al., 'Rapid Blood-Pressure Lowering in Patients with Acute Intracerebral Hemorrhage', NEW ENGLAND JOURNAL OF MEDICINE, 368 2355-2365 (2013) [C1]
DOI10.1056/NEJMoa1214609Author URL
CitationsScopus - 143Web of Science - 129
2013Bivard A, Levi C, Spratt N, Parsons M, 'Perfusion CT in Acute Stroke: A Comprehensive Analysis of Infarct and Penumbra', RADIOLOGY, 267 543-550 (2013) [C1]
DOI10.1148/radiol.12120971Author URL
CitationsScopus - 26Web of Science - 22
Co-authorsNeil Spratt, Chris Levi
2013Wintermark M, Fiehler J, Kudo K, Liebeskind DS, Luby M, Michel P, et al., 'International Survey of Acute Stroke Imaging Capabilities We Need You!', STROKE, 44 2091-2091 (2013) [C3]
DOI10.1161/STROKEAHA.113.001441Author URL
2013Parsons MW, Albers GW, 'MR RESCUE: Is the glass half-full or half-empty?', Stroke, 44 2055-2057 (2013) [C2]
DOI10.1161/STROKEAHA.113.001443
CitationsScopus - 12Web of Science - 9
2013Wintermark M, Albers GW, Broderick JP, Demchuk AM, Fiebach JB, Fiehler J, et al., 'Acute stroke imaging research roadmap II', Stroke, 44 2628-2639 (2013) [C1]
DOI10.1161/STROKEAHA.113.002015
CitationsScopus - 29Web of Science - 24
2013Yassi N, Parsons MW, Christensen S, Sharma G, Bivard A, Donnan GA, et al., 'Prediction of Poststroke Hemorrhagic Transformation Using Computed Tomography Perfusion', Stroke, 44 3039-3043 (2013) [C1]
DOI10.1161/STROKEAHA.113.002396Author URL
CitationsScopus - 1Web of Science - 3
Co-authorsChris Levi
2013Campbell BCV, Christensen S, Tress BM, Churilov L, Desmond PM, Parsons MW, et al., 'Failure of collateral blood flow is associated with infarct growth in ischemic stroke', JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 33 1168-1172 (2013) [C1]
DOI10.1038/jcbfm.2013.77Author URL
CitationsScopus - 19Web of Science - 22
Co-authorsChris Levi
2013Menon BK, O'Brien B, Bivard A, Spratt NJ, Demchuk AM, Miteff F, et al., 'Assessment of leptomeningeal collaterals using dynamic CT angiography in patients with acute ischemic stroke', Journal of Cerebral Blood Flow and Metabolism, 33 365-371 (2013) [C1]
CitationsScopus - 29Web of Science - 28
Co-authorsNeil Spratt, Chris Levi
2013Campbell BCV, Christensen S, Parsons MW, Churilov L, Desmond PM, Barber PA, et al., 'Advanced imaging improves prediction of hemorrhage after stroke thrombolysis', ANNALS OF NEUROLOGY, 73 510-519 (2013) [C1]
DOI10.1002/ana.23837Author URL
CitationsScopus - 12Web of Science - 12
Co-authorsChris Levi
2013Bivard A, Stanwell PT, Levi CR, Parsons MW, 'Arterial spin labeling identifies tissue salvage and good clinical recovery after acute ischemic stroke', Journal of Neuroimaging, 23 391-396 (2013) [C1]
CitationsScopus - 8Web of Science - 10
Co-authorsChris Levi
2013Kitsos GH, Hubbard IJ, Kitsos AR, Parsons MW, 'The Ipsilesional Upper Limb Can Be Affected following Stroke', SCIENTIFIC WORLD JOURNAL, (2013) [C1]
DOI10.1155/2013/684860Author URL
Co-authorsIsobel Hubbard
2013Jolly TAD, Bateman GA, Levi CR, Parsons MW, Michie PT, Karayanidis F, 'Early detection of microstructural white matter changes associated with arterial pulsatility', FRONTIERS IN HUMAN NEUROSCIENCE, 7 (2013) [C1]
DOI10.3389/fnhum.2013.00782Author URL
CitationsScopus - 2Web of Science - 3
Co-authorsFrini Karayanidis, Pat Michie, Chris Levi
2013Bladin C, Levi C, Parsons M, 'Stroke thrombolysis: Leaving the past, understanding the present and moving forward ...', EMERGENCY MEDICINE AUSTRALASIA, 25 195-196 (2013) [C3]
DOI10.1111/1742-6723.12025Author URL
CitationsWeb of Science - 3
Co-authorsChris Levi
2013Zareie H, Quain DA, Parsons M, Inder KJ, McElduff P, Miteff F, et al., 'The influence of anterior cerebral artery flow diversion measured by transcranial Doppler on acute infarct volume and clinical outcome in anterior circulation stroke', INTERNATIONAL JOURNAL OF STROKE, 8 228-234 (2013) [C1]
DOI10.1111/j.1747-4949.2012.00801.xAuthor URL
CitationsScopus - 2Web of Science - 2
Co-authorsKerry Inder, Chris Levi, Neil Spratt
2013Anderson C, Heeley E, Heritier S, Arima H, Woodward M, Lindley R, et al., 'Statistical analysis plan for the second INTEnsive blood pressure Reduction in Acute Cerebral hemorrhage Trial (INTERACT2): a large-scale investigation to solve longstanding controversy over the most appropriate management of elevated blood pressure in the hyperacute phase of intracerebral hemorrhage', INTERNATIONAL JOURNAL OF STROKE, 8 327-328 (2013) [C2]
DOI10.1111/ijs.12004Author URL
CitationsWeb of Science - 1
2013Churilov L, Liu D, Ma H, Christensen S, Nagakane Y, Campbell B, et al., 'Multiattribute selection of acute stroke imaging software platform for Extending the Time for Thrombolysis in Emergency Neurological Deficits (EXTEND) clinical trial', International Journal of Stroke, 8 204-210 (2013) [C1]
DOI10.1111/j.1747-4949.2012.00787.xAuthor URL
CitationsScopus - 4Web of Science - 5
Co-authorsChris Levi
2013Meretoja A, Davis SM, Campbell BCV, Yassi N, Yan B, Churilov L, et al., 'The Spot sign and Tranexamic acid On Preventing ICH growth - AUStralasia Trial (STOP-AUST): Protocol of a phase II randomized, placebo-controlled, double-blind, multicenter trial', International Journal of Stroke, (2013) [C3]

Rationale: No evidence-based acute therapies exist for intracerebral hemorrhage. Intracerebral hemorrhage growth is an important determinant of patient outcome. Tranexamic acid is known to reduce hemorrhage in other conditions. Aim: The study aims to test the hypothesis that intracerebral hemorrhage patients selected with computed tomography angiography contrast extravasation 'spot sign' will have lower rates of hematoma growth when treated with intravenous tranexamic acid within 4·5-hours of stroke onset compared with placebo. Design: The Spot sign and Tranexamic acid On Preventing ICH growth - AUStralasia Trial is a multicenter, prospective, 1:1 randomized, double-blind, placebo-controlled, investigator-initiated, academic Phase II trial. Intracerebral hemorrhage patients fulfilling clinical criteria (e.g. Glasgow Coma Scale >7, intracerebral hemorrhage volume <70ml, no identified secondary cause of intracerebral hemorrhage, no thrombotic events within the previous 12 months, no planned surgery) and demonstrating contrast extravasation on computed tomography angiography will receive either intravenous tranexamic acid 1g 10-min bolus followed by 1g eight-hour infusion or placebo. A second computed tomography will be performed at 24 ± 3 hours to evaluate intracerebral hemorrhage growth and patients followed up for three-months. Study outcomes: The primary outcome measure is presence of intracerebral hemorrhage growth by 24 ± 3 hours, defined as either >33% or >6ml increase from baseline, and will be adjusted for baseline intracerebral hemorrhage volume. Secondary outcome measures include growth as a continuous measure, thromboembolic events, and the three-month modified Rankin Scale score. Discussion: This is the first trial to evaluate the efficacy of tranexamic acid in intracerebral hemorrhage patients selected based on an imaging biomarker of high likelihood of hematoma growth. The trial is registered as NCT01702636. © 2013 World Stroke Organization.

DOI10.1111/ijs.12132
CitationsWeb of Science - 3
Co-authorsNeil Spratt, Chris Levi
2013Mcleod DD, Parsons MW, Hood R, Hiles B, Allen J, Mccann SK, et al., 'Perfusion computed tomography thresholds defining ischemic penumbra and infarct core: Studies in a rat stroke model', International Journal of Stroke, (2013)

Background: Perfusion computed tomography is becoming more widely used as a clinical imaging tool to predict potentially salvageable tissue (ischemic penumbra) after ischemic stroke and guide reperfusion therapies. Aims: The study aims to determine whether there are important changes in perfusion computed tomography thresholds defining ischemic penumbra and infarct core over time following stroke. Methods: Permanent middle cerebral artery occlusion was performed in adult outbred Wistar rats (n=6) and serial perfusion computed tomography scans were taken every 30 mins for 2h. To define infarction thresholds at 1h and 2h post-stroke, separate groups of rats underwent 1h (n=6) and 2h (n=6) of middle cerebral artery occlusion followed by reperfusion. Infarct volumes were defined by histology at 24h. Co-registration with perfusion computed tomography maps (cerebral blood flow, cerebral blood volume, and mean transit time) permitted pixel-based analysis of thresholds defining infarction, using receiver operating characteristic curves. Results: Relative cerebral blood flow was the perfusion computed tomography parameter that most accurately predicted penumbra (area under the curve=0·698) and also infarct core (area under the curve=0·750). A relative cerebral blood flow threshold of <75% of mean contralateral cerebral blood flow most accurately predicted penumbral tissue at 0·5h (area under the curve=0·660), 1h (area under the curve=0·659), 1·5h (area under the curve=0·636), and 2h (area under the curve=0·664) after stroke onset. A relative cerebral blood flow threshold of <55% of mean contralateral most accurately predicted infarct core at 1h (area under the curve=0·765) and at 2h (area under the curve=0·689) after middle cerebral artery occlusion. Conclusions: The data provide perfusion computed tomography defined relative cerebral blood flow thresholds for infarct core and ischemic penumbra within the first two hours after experimental stroke in rats. These thresholds were shown to be stable to define the volume of infarct core and penumbra within this time window. © 2013 World Stroke Organization.

DOI10.1111/ijs.12147
CitationsScopus - 3
Co-authorsChris Levi, Neil Spratt, Damian Mcleod
2013Marquez J, van Vliet P, Mcelduff P, Lagopoulos J, Parsons M, 'Transcranial direct current stimulation (tDCS): Does it have merit in stroke rehabilitation? A systematic review', International Journal of Stroke, (2013)

Transcranial direct current stimulation has been gaining increasing interest as a potential therapeutic treatment in stroke recovery. We performed a systematic review with meta-analysis of randomized controlled trials to collate the available evidence in adults with residual motor impairments as a result of stroke. The primary outcome was change in motor function or impairment as a result of transcranial direct current stimulation, using any reported electrode montage, with or without adjunct physical therapy. The search yielded 15 relevant studies comprising 315 subjects. Compared with sham, cortical stimulation did not produce statistically significant improvements in motor performance when measured immediately after the intervention (anodal stimulation: facilitation of the affected cortex: standardized mean difference=0·05, P=0·71; cathodal stimulation: inhibition of the nonaffected cortex: standardized mean difference=0·39, P=0·08; bihemispheric stimulation: standardized mean difference=0·24, P=0·39). When the data were analyzed according to stroke characteristics, statistically significant improvements were evident for those with chronic stroke (standardized mean difference=0·45, P=0·01) and subjects with mild-to-moderate stroke impairments (standardized mean difference=0·37, P=0·02). Transcranial direct current stimulation is likely to be effective in enhancing motor performance in the short term when applied selectively to patients with stroke. Given the range of stimulation variables and heterogeneous nature of stroke, this modality is still experimental and further research is required to determine its clinical merit in stroke rehabilitation. © 2013 World Stroke Organization.

DOI10.1111/ijs.12169
CitationsScopus - 3
Co-authorsPaulette Vanvliet, Jodie Marquez
2013Magin P, Lasserson D, Parsons M, Spratt N, Evans M, Russell M, et al., 'Referral and triage of patients with transient ischemic attacks to an acute access clinic: Risk stratification in an Australian setting', International Journal of Stroke, 8 81-89 (2013) [C1]

Background: Transient ischemic attacks and minor stroke entail considerable risk of completed stroke but this risk is reduced by prompt assessment and treatment. Risk can be stratified according to the ABCD2 prediction score. Current guidelines suggest specialist assessment and treatment within 24h for high-risk event (ABCD2 score 4-7) and seven-days for low-risk event (ABCD2 score =3). Aims: The study aims to establish paths to care and outcomes for patients referred by general practitioners and emergency departments to an Australian acute access transient ischemic attack service. Methods: This is a prospective audit. Primary outcomes were time from event to referral, from referral to clinic appointment, and from event to appointment. ABCD2 score was calculated for each event. Time from event was modeled using Cox proportional hazards regression. Results: There were 231 clinic attendees (general practitioner: 127; emergency department: 104). Mean time from event to referral was 9·2 days (SD 23·7, median 2), from referral to being seen in the clinic was 13·6 days (SD 19·0, median 7), and from event to being seen in the clinic was 17·2 days (SD 27·1, median 10). Of low-risk patients, 38·5% were seen within seven-days of event. Of high-risk patients, 36·7% were seen within one-day. ABCD2 score was not a significant predictor of any time interval from event to clinic attendance. There were no completed strokes prior to clinic attendance. Conclusions: Times from event to clinic assessment were in excess of current recommendations and risk stratification was suboptimal, though short-term outcomes were good. Improvements in referral mechanisms may enhance risk-stratification and triage. © 2013 World Stroke Organization.

DOI10.1111/ijs.12014
CitationsWeb of Science - 2
Co-authorsNeil Spratt, Chris Levi, Parker Magin
2013Carey LM, Crewther S, Salvado O, Lindén T, Connelly A, Wilson W, et al., 'STroke imAging pRevention and treatment (START): A longitudinal stroke cohort study: Clinical trials protocol', International Journal of Stroke, (2013)

Rationale: Stroke and poststroke depression are common and have a profound and ongoing impact on an individual's quality of life. However, reliable biological correlates of poststroke depression and functional outcome have not been well established in humans. Aims: Our aim is to identify biological factors, molecular and imaging, associated with poststroke depression and recovery that may be used to guide more targeted interventions. Design: In a longitudinal cohort study of 200 stroke survivors, the START - STroke imAging pRevention and Treatment cohort, we will examine the relationship between gene expression, regulator proteins, depression, and functional outcome. Stroke survivors will be investigated at baseline, 24h, three-days, three-months, and 12 months poststroke for blood-based biological associates and at days 3-7, three-months, and 12 months for depression and functional outcomes. A sub-group (n=100), the PrePARE: Prediction and Prevention to Achieve optimal Recovery Endpoints after stroke cohort, will also be investigated for functional and structural changes in putative depression-related brain networks and for additional cognition and activity participation outcomes. Stroke severity, diet, and lifestyle factors that may influence depression will be monitored. The impact of depression on stroke outcomes and participation in previous life activities will be quantified. Study Outcomes: Clinical significance lies in the identification of biological factors associated with functional outcome to guide prevention and inform personalized and targeted treatments. Evidence of associations between depression, gene expression and regulator proteins, functional and structural brain changes, lifestyle and functional outcome will provide new insights for mechanism-based models of poststroke depression. © 2013 World Stroke Organization.

DOI10.1111/ijs.12190
CitationsScopus - 1
2013McLeod DD, Beard DJ, Parsons MW, Levi CR, Calford MB, Spratt NJ, 'Inadvertent Occlusion of the Anterior Choroidal Artery Explains Infarct Variability in the Middle Cerebral Artery Thread Occlusion Stroke Model', PLOS ONE, 8 (2013) [C1]
DOI10.1371/journal.pone.0075779Author URL
CitationsScopus - 3Web of Science - 2
Co-authorsDamian Mcleod, Neil Spratt, Chris Levi
2012Campbell BCV, Tu HTH, Christensen S, Desmond PM, Levi CR, Bladin CF, et al., 'Assessing response to stroke thrombolysis validation of 24-Hour multimodal magnetic resonance imaging', Archives of Neurology, 69 46-50 (2012) [C1]
CitationsScopus - 21Web of Science - 20
Co-authorsChris Levi
2012O'Brien B, Parsons MW, Anderson CS, 'Sudden limb weakness', Medical Journal of Australia, 196 572-577 (2012) [C3]
2012Delcourt C, Huang Y, Arima H, Chalmers J, Davis SM, Heeley EL, et al., 'Hematoma growth and outcomes in intracerebral hemorrhage The INTERACT1 study', NEUROLOGY, 79 314-319 (2012) [C1]
DOI10.1212/WNL.0b013e318260cbbaAuthor URL
CitationsScopus - 29Web of Science - 27
2012González RG, 'Tenecteplase versus alteplase for acute ischemic stroke', New England Journal of Medicine, 367 275-276 (2012) [C3]
DOI10.1056/NEJMc1205829
CitationsScopus - 2
2012Parsons M, Levi C, Davis S, 'The authors reply', New England Journal of Medicine, 367 276-276 (2012) [C3]
DOI10.1056/NEJMc1205829
2012Parsons MW, Spratt NJ, Bivard A, Campbell B, Chung K, Miteff F, et al., 'A randomized trial of tenecteplase versus alteplase for acute ischemic stroke', New England Journal of Medicine, 366 1099-1107 (2012) [C1]
CitationsScopus - 131Web of Science - 113
Co-authorsNeil Spratt, Chris Levi
2012Parsons MW, Levi CR, Davis S, 'Tenecteplase versus alteplase for acute ischemic stroke: The authors reply', New England Journal of Medicine, 367 276 (2012) [C1]
Co-authorsChris Levi
2012Campbell BCV, Christensen S, Levi CR, Desmond PM, Donnan GA, Davis SM, Parsons MW, 'Comparison of computed tomography perfusion and magnetic resonance imaging perfusion-diffusion mismatch in ischemic stroke', Stroke, 43 2648-2653 (2012) [C1]
CitationsScopus - 20Web of Science - 19
Co-authorsChris Levi
2012Arima H, Huang YN, Wang JG, Heeley E, Delcourt C, Parsons MW, et al., 'Earlier blood pressure-lowering and greater attenuation of hematoma growth in acute intracerebral hemorrhage: INTERACT pilot phase', Stroke, 43 2236-2238 (2012) [C3]
CitationsWeb of Science - 12
2012Nagakane Y, Christensen S, Ogata T, Churilov L, Ma H, Parsons MW, et al., 'Moving beyond a single perfusion threshold to define penumbra: A novel probabilistic mismatch definition', Stroke, 43 1548-1555 (2012) [C1]
CitationsScopus - 10Web of Science - 12
Co-authorsChris Levi
2012Parsons MW, Levi CR, 'Reperfusion trials for acute ischaemic stroke', The Lancet, 380 706-708 (2012) [C3]
Co-authorsChris Levi
2012Campbell BCV, Purushotham A, Christensen S, Desmond PM, Nagakane Y, Parsons MW, et al., 'The infarct core is well represented by the acute diffusion lesion: sustained reversal is infrequent', Journal of Cerebral Blood Flow and Metabolism, 32 50-56 (2012) [C1]
CitationsScopus - 46Web of Science - 47
2012Holliday EG, Maguire JM, Evans T-J, Koblar SA, Jannes J, Sturm J, et al., 'Common variants at 6p21.1 are associated with large artery atherosclerotic stroke', Nature Genetics, 44 1147-1153 (2012) [C1]
CitationsScopus - 44Web of Science - 44
Co-authorsPablo Moscato, Chris Levi, Wayne Smith, Jane Maguire, Lisa Lincz, John Attia, Liz Holliday, Christopher Oldmeadow, Rodney Scott, Roseanne Peel
2012Ma H, Parsons MW, Christensen S, Campbell BCV, Churilov L, Connelly A, et al., 'A multicentre, randomized, double-blinded, placebo-controlled phase III study to investigate EXtending the time for Thrombolysis in Emergency Neurological Deficits (EXTEND)', International Journal of Stroke, 7 74-80 (2012) [C1]
CitationsScopus - 68Web of Science - 58
2012Bivard A, Parsons M, 'ASPECTaSaurus (a dinosaur)?', Int J Stroke, 7 564-564 (2012) [C1]
DOI10.1111/j.1747-4949.2012.00854.xAuthor URL
CitationsScopus - 3Web of Science - 2
2012Davis S, Campbell B, Christensen S, Ma H, Desmond P, Parsons MW, et al., 'Perfusion/diffusion mismatch is valid and should be used for selecting delayed interventions', Translational Stroke Research, 3 188-197 (2012) [C1]
CitationsScopus - 5Web of Science - 4
Co-authorsChris Levi
2012Levi CR, Zareie H, Parsons MW, 'Transcranial Doppler in acute stroke management - A 'real-time' bed-side guide to reperfusion and collateral flow', Perspectives in Medicine, 1 185-193 (2012) [C1]
Co-authorsChris Levi
2011Bivard A, Spratt NJ, Levi CR, Parsons MW, 'Acute stroke thrombolysis: Time to dispense with the clock and move to tissue-based decision making?', Expert Review of Cardiovascular Therapy, 9 451-461 (2011) [C1]
CitationsScopus - 5
Co-authorsNeil Spratt, Chris Levi
2011McLeod DD, Parsons MW, Levi CR, Beautement S, Buxton D, Roworth B, Spratt NJ, 'Establishing a rodent stroke perfusion computed tomography model', International Journal of Stroke, 6 284-289 (2011) [C1]
DOI10.1111/j.1747-4949.2010.00564.x
CitationsScopus - 10Web of Science - 9
Co-authorsDamian Mcleod, Chris Levi, Neil Spratt
2011Donnan GA, Davis SM, Parsons MW, Ma H, Dewey HM, Howells DW, 'How to make better use of thrombolytic therapy in acute ischemic stroke', Nature Reviews Neurology, 7 400-409 (2011) [C1]
CitationsScopus - 45Web of Science - 41
2011Bivard A, Spratt NJ, Levi CR, Parsons MW, 'Perfusion computer tomography: Imaging and clinical validation in acute ischaemic stroke', Brain, 134 3408-3416 (2011) [C1]
CitationsScopus - 33Web of Science - 35
Co-authorsChris Levi, Neil Spratt
2011Simpson MA, Dewey HM, Parsons MW, 'In reply', Medical Journal of Australia, 194 212-213 (2011) [C3]
2011Simpson MA, Dewey HM, Parsons MW, 'Thrombolysis for acute stroke in Australia', Medical Journal of Australia, 194 212-213 (2011) [C3]
2011Hunter AJ, Snodgrass SN, Quain D, Parsons MW, Levi CR, 'HOBOE (head-of-bed optimization of elevation) study: Association of higher angle with reduced cerebral blood flow velocity in acute ischemic stroke', Physical Therapy, 91 1503-1512 (2011) [C1]
DOI10.2522/ptj.20100271
CitationsScopus - 6Web of Science - 4
Co-authorsSuzanne Snodgrass, Chris Levi
2011Nagakane Y, Christensen S, Brekenfeld C, Ma H, Churilov L, Parsons MW, et al., 'EPITHET positive result after reanalysis using baseline diffusion-weighted imaging/perfusion-weighted imaging co-registration', Stroke, 42 59-64 (2011) [C1]
DOI10.1161/strokeaha.110.580464
CitationsScopus - 45Web of Science - 37
Co-authorsChris Levi
2011Parsons MW, 'Advanced brain imaging studies should be performed in patients with suspected stroke presenting within 4.5 hours of symptom onset', Stroke, 42 2666-2667 (2011) [C3]
DOI10.1161/STROKEAHA.111.621771
CitationsScopus - 6Web of Science - 5
2011Campbell BCV, Christensen S, Levi CR, Desmond PM, Donnan GA, Davis SM, Parsons MW, 'Cerebral blood flow is the optimal CT perfusion parameter for assessing infarct core', Stroke, 42 3435-3440 (2011) [C1]
DOI10.1161/strokeaha.111.618355
CitationsScopus - 56Web of Science - 48
Co-authorsChris Levi
2011Parsons MW, 'Treating as early as Possible with Thrombolysis Is Crucial, but Can We Do Better in the Sub-4.5-Hour Time Window?', Cerebrovascular Diseases, 31 229 (2011) [C3]
DOI10.1159/000322555
CitationsScopus - 1Web of Science - 1
2011Parsons MW, Bivard A, McElduff P, Spratt NJ, Levi CR, 'Defining the extent of irreversible brain ischemia using perfusion computed tomography', Cerebrovascular Diseases, 31 238-245 (2011) [C1]
DOI10.1159/000321897
CitationsScopus - 42Web of Science - 38
Co-authorsChris Levi, Neil Spratt
2011Campbell BCV, Costello C, Christensen S, Ebinger M, Parsons MW, Desmond PM, et al., 'Fluid-attenuated inversion recovery hyperintensity in acute ischemic stroke may not predict hemorrhagic transformation', Cerebrovascular Diseases, 32 401-405 (2011) [C1]
CitationsScopus - 9Web of Science - 8
Co-authorsChris Levi
2011Thomas L, Rivett DA, Attia JR, Parsons MW, Levi CR, 'Risk factors and clinical features of craniocervical arterial dissection', Manual Therapy, 16 351-356 (2011) [C1]
DOI10.1016/j.math.2010.12.008
CitationsScopus - 18Web of Science - 14
Co-authorsJohn Attia, Chris Levi, Lucy Thomas, Darren Rivett
2010Ahmed N, Wahlgren N, Grond M, Hennerici M, Lees KR, Mikulik R, et al., 'Implementation and outcome of thrombolysis with alteplase 3-4.5 h after an acute stroke: An updated analysis from SITS-ISTR', The Lancet Neurology, 9 866-874 (2010) [C1]
DOI10.1016/S1474-4422(10)70165-4
CitationsScopus - 125Web of Science - 109
2010Lees KR, Bluhmki E, Von Kummer R, Brott TG, Toni D, Grotta JC, et al., 'Time to treatment with intravenous alteplase and outcome in stroke: an updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials', The Lancet, 375 1695-1703 (2010) [C1]
DOI10.1016/S0140-6736(10)60491-6
CitationsScopus - 718Web of Science - 644
Co-authorsJohn Attia, Chris Levi
2010Delcourt C, Huang Y, Wang J, Heeley E, Lindley R, Stapf C, et al., 'The second (main) phase of an open, randomised, multicentre study to investigate the effectiveness of an intensive blood pressure reduction in acute cerebral haemorrhage trial (INTERACT2)', International Journal of Stroke, 5 110-116 (2010) [C1]
DOI10.1111/j.1747-4949.2010.00415.x
CitationsScopus - 61Web of Science - 56
2010Garnett AR, Marsden DL, Parsons MW, Quain DA, Spratt NJ, Loudfoot AR, et al., 'The rural Prehospital Acute Stroke Triage (PAST) trial protocol: A controlled trial for rapid facilitated transport of rural acute stroke patients to a regional stroke centre', International Journal of Stroke, 5 506-513 (2010) [C1]
DOI10.1111/j.1747-4949.2010.00522.x
CitationsScopus - 9Web of Science - 8
Co-authorsNeil Spratt, Chris Levi
2010Parsons MW, 'Portable computed tomography scanners in community hospitals: are they necessary?', International Journal of Stroke, 5 67 (2010) [C3]
DOI10.1111/j.1747-4949.2010.00407.x
2010Simpson MA, Dewey HM, Churilov L, Ahmed N, Bladin CF, Schultz D, et al., 'Thrombolysis for acute stroke in Australia: Outcomes from the Safe Implementation of Thrombolysis in Stroke registry (2002-2008)', Medical Journal of Australia, 193 439-443 (2010) [C1]
CitationsScopus - 16Web of Science - 13
Co-authorsChris Levi
2010Chemmanam T, Campbell BCV, Christensen S, Nagakane Y, Desmond PM, Bladin CF, et al., 'Ischemic diffusion lesion reversal is uncommon and rarely alters perfusion-diffusion mismatch', Neurology, 75 1040-1047 (2010) [C1]
DOI10.1212/WNL.0b013e3181f39ab6
CitationsScopus - 51Web of Science - 45
Co-authorsChris Levi
2010Anderson CS, Huang YN, Arima H, Heeley E, Skulina C, Parsons MW, et al., 'Effects of early intensive blood pressure-lowering treatment on the growth of hematoma and perihematomal edema in acute intracerebral hemorrhage: The Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT)', Stroke, 41 307-312 (2010) [C1]
DOI10.1161/STROKEAHA.109.561795
CitationsScopus - 100Web of Science - 78
2010Campbell BCV, Christensen S, Butcher KS, Gordon I, Parsons MW, Desmond PM, et al., 'Regional very low cerebral blood volume predicts hemorrhagic transformation better than diffusion-weighted imaging volume and thresholded apparent diffusion coefficient in acute ischemic stroke', Stroke, 41 82-88 (2010) [C1]
DOI10.1161/STROKEAHA.109.562116
CitationsScopus - 50Web of Science - 47
Co-authorsChris Levi
2010Butcher K, Christensen S, Parsons MW, De Silva DA, Ebinger M, Levi CR, et al., 'Postthrombolysis blood pressure elevation is associated with hemorrhagic transformation', Stroke, 41 72-77 (2010) [C1]
DOI10.1161/STROKEAHA.109.563767
CitationsScopus - 29Web of Science - 27
Co-authorsChris Levi
2010De Silva DA, Brekenfeld C, Ebinger M, Christensen S, Barber PA, Butcher KS, et al., 'The benefits of intravenous thrombolysis relate to the site of baseline arterial occlusion in the echoplanar imaging thrombolytic evaluation trial (EPITHET)', Stroke, 41 295-299 (2010) [C1]
DOI10.1161/STROKEAHA.109.562827
CitationsScopus - 47Web of Science - 42
Co-authorsChris Levi
2010Pickering RL, Hubbard IJ, Baker KG, Parsons MW, 'Assessment of the upper limb in acute stroke: The validity of hierarchal scoring for the Motor Assessment Scale', Australian Occupational Therapy Journal, 57 174-182 (2010) [C1]
DOI10.1111/j.1440-1630.2009.00810.x
CitationsScopus - 4Web of Science - 3
Co-authorsIsobel Hubbard
2010Arima H, Anderson CS, Wang JG, Huang Y, Heeley E, Neal B, et al., 'Lower treatment blood pressure is associated with greatest reduction in hematoma growth after acute intracerebral hemorrhage', Hypertension, 56 852-858 (2010) [C1]
DOI10.1161/HYPERTENSIONAHA.110.154328
CitationsScopus - 28Web of Science - 25
2010Parsons MW, Christensen S, McElduff P, Levi CR, Butcher KS, De Silva DA, et al., 'Pretreatment diffusion- and perfusion-MR lesion volumes have a crucial influence on clinical response to stroke thrombolysis', Journal of Cerebral Blood Flow and Metabolism, 30 1214-1225 (2010) [C1]
DOI10.1038/jcbfm.2010.3
CitationsScopus - 88Web of Science - 80
Co-authorsChris Levi
2010Johnston KC, Parsons MW, 'Aggressive glucose control in acute stroke: Is the answer in the imaging?', Annals of Neurology, 67 557-558 (2010) [C3]
DOI10.1002/ana.22046
CitationsScopus - 1Web of Science - 1
2010Parsons MW, 'Commentary: Echocardiography in the detection of cardioembolism in a stroke population', Journal of Clinical Neuroscience, 17 566-566 (2010) [C3]
DOI10.1016/j.jocn.2010.01.001
2010Campbell BCV, Christensen S, Foster SJ, Desmond PM, Parsons MW, Butcher KS, et al., 'Visual assessment of perfusion-diffusion mismatch is inadequate to select patients for thrombolysis', Cerebrovascular Diseases, 29 592-596 (2010) [C1]
DOI10.1159/000311080
CitationsScopus - 34Web of Science - 33
Co-authorsChris Levi
2010Tu HTH, Campbell BCV, Christensen S, Collins M, De Silva DA, Butcher KS, et al., 'Pathophysiological determinants of worse stroke outcome in atrial fibrillation', Cerebrovascular Diseases, 30 389-395 (2010) [C1]
DOI10.1159/000316886
CitationsScopus - 34Web of Science - 25
Co-authorsChris Levi
2010Marsden DL, Spratt NJ, Walker R, Barker DJ, Attia JR, Pollack MR, et al., 'Trends in stroke attack rates and case fatality in the Hunter Region, Australia 1996-2008', Cerebrovascular Diseases, 30 500-507 (2010) [C1]
DOI10.1159/000319022
CitationsScopus - 16Web of Science - 16
Co-authorsChris Levi, Neil Spratt, John Attia
2010De Silva DA, Ebinger M, Christensen S, Parsons MW, Levi CR, Butcher K, et al., 'Baseline diabetic status and admission blood glucose were poor prognostic factors in the EPITHET trial', Cerebrovascular Diseases, 29 14-21 (2010) [C1]
DOI10.1159/000255969
CitationsScopus - 29Web of Science - 27
Co-authorsChris Levi
2009Levi CR, Bateman GA, Spratt NJ, McElduff P, Parsons MW, Miteff F, 'The independent predictive utility of computed tomography angiographic collateral status in acute ischaemic stroke', Brain, 132 2231-2238 (2009) [C1]
DOI10.1093/brain/awp155
CitationsScopus - 107Web of Science - 101
Co-authorsChris Levi, Neil Spratt
2009Parsons MW, Miteff F, Bateman GA, Spratt NJ, Loiselle A, Attia JR, Levi CR, 'Acute ischemic stroke imaging-guided tenecteplase treatment in an extended time window', Neurology, 72 915-921 (2009) [C1]
DOI10.1212/01.wnl.0000344168.05315.9d
CitationsScopus - 62Web of Science - 48
Co-authorsJohn Attia, Neil Spratt, Chris Levi
2009Arima H, Wang JG, Huang Y, Heeley E, Skulina C, Parsons MW, et al., 'Significance of perihematomal edema in acute intracerebral hemorrhage: The INTERACT trial', Neurology, 73 1963-1968 (2009) [C1]
DOI10.1212/wnl.0b013e3181c55ed3
CitationsScopus - 53Web of Science - 54
2009Ebinger M, Christensen S, De Silva DA, Parsons MW, Levi CR, Butcher KS, et al., 'Expediting MRI-based proof-of-concept stroke trials using an earlier imaging end point', Stroke, 40 1353-1358 (2009) [C1]
DOI10.1161/strokeaha.108.532622
CitationsScopus - 23Web of Science - 20
Co-authorsChris Levi
2009Ebinger M, Iwanaga T, Prosser JF, De Silva DA, Christensen S, Collins M, et al., 'Clinical-diffusion mismatch and benefit from thrombolysis 3 to 6 hours after acute stroke', Stroke, 40 2572-2574 (2009) [C1]
DOI10.1161/strokeaha.109.548073
CitationsScopus - 23Web of Science - 23
Co-authorsChris Levi
2009De Silva DA, Fink JN, Christensen S, Ebinger M, Bladin C, Levi CR, et al., 'Assessing reperfusion and recanalization as markers of clinical outcomes after intravenous thrombolysis in the echoplanar imaging thrombolytic evaluation trial (EPITHET)', Stroke, 40 2872-2874 (2009) [C1]
DOI10.1161/strokeaha.108.543595
CitationsScopus - 46Web of Science - 38
Co-authorsChris Levi
2009Hubbard IJ, Vyslysel G, Parsons MW, 'Interprofessional, practice-driven research: Reflections of one 'community of inquiry' based in acute stroke', Journal of Allied Health, 38 E69-E74 (2009) [C1]
Co-authorsIsobel Hubbard
2009Hubbard IJ, Parsons MW, Neilson C, Carey LM, 'Task-specific training: Evidence for and translation to clinical practice', Occupational Therapy International, 16 175-189 (2009) [C1]
DOI10.1002/oti.275
CitationsScopus - 58Web of Science - 47
Co-authorsIsobel Hubbard
2009Ebinger M, De Silva DA, Christensen S, Parsons MW, Markus R, Donnan GA, Davis SM, 'Imaging the penumbra: Strategies to detect tissue at risk after ischemic stroke', Journal of Clinical Neuroscience, 16 178-187 (2009) [C1]
DOI10.1016/j.jocn.2008.04.002
CitationsScopus - 26Web of Science - 20
2009Levi CR, Lindley R, Smith B, Bladin C, Parsons MW, Read S, et al., 'The implementation of intravenous tissue plasminogen activator in acute ischaemic stroke: A scientific position statement from the National Stroke Foundation and the Stroke Society of Australasia', Internal Medicine Journal, 39 317-324 (2009) [C1]
DOI10.1111/j.1445-5994.2009.01938.x
CitationsScopus - 10Web of Science - 6
Co-authorsChris Levi
2008Anderson CS, Huang Y, Wang JG, Arima H, Neal B, Peng B, et al., 'Intensive blood pressure reduction in acute cerebral haemorrhage trial (INTERACT): a randomised pilot trial', The Lancet Neurology, 7 391-399 (2008) [C1]
DOI10.1016/s1474-4422(08)70069-3
CitationsScopus - 335Web of Science - 276
2008Davis SM, Donnan GA, Parsons MW, Levi CR, Butcher KS, Peeters A, et al., 'Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): A placebo-controlled randomised trial', The Lancet Neurology, 7 299-309 (2008) [C1]
DOI10.1016/s1474-4422(08)70044-9
CitationsScopus - 527Web of Science - 469
Co-authorsJohn Attia, Chris Levi
2008Davis SM, Donnan GA, Parsons MW, Levi CR, Butcher KS, Barber PA, et al., 'EPITHET: Where next? Authors' reply', The Lancet Neurology, 7 571-572 (2008) [C3]
DOI10.1016/s1474-4422(08)70124-8
CitationsWeb of Science - 1
Co-authorsChris Levi
2008Parsons MW, 'Perfusion CT: Is it clinically useful?', International Journal of Stroke, 3 41-50 (2008) [C1]
DOI10.1111/j.1747-4949.2008.00175.x
CitationsScopus - 35Web of Science - 34
2008Quain DA, Parsons MW, Loudfoot AR, Spratt NJ, Evans MK, Russell ML, et al., 'Improving access to acute stroke therapies: A controlled trial of organised pre-hospital and emergency care', Medical Journal of Australia, 189 429-433 (2008) [C1]
CitationsScopus - 59Web of Science - 50
Co-authorsChris Levi, Neil Spratt, John Attia
2008Maguire JM, Thakkinstian A, Sturm J, Levi CR, Lincz L, Parsons MW, et al., 'Polymorphisms in platelet glycoprotein 1b [alpha] and factor VII and risk of ischemic stroke', Stroke, 39 1710-1716 (2008) [C1]
DOI10.1161/strokeaha.107.507228
CitationsScopus - 24Web of Science - 23
Co-authorsJane Maguire, Lisa Lincz, John Attia, Chris Levi
2008Butcher K, Parsons MW, Allport L, Lee SB, Barber PA, Tress B, et al., 'Rapid assessment of perfusion-diffusion mismatch', Stroke, 39 75-81 (2008) [C1]
DOI10.1161/strokeaha.107.490524
CitationsScopus - 44Web of Science - 46
2007Attia JR, Thakkinstian A, Wang Y, Lincz L, Parsons MW, Sturm J, et al., 'The PAI-1 4G/5G gene polymorphism and ischemic stroke: An association study and meta-analysis', Journal of Stroke and Cerebrovascular Diseases, 16 173-179 (2007) [C1]
DOI10.1016/j.jstrokecerebrovasdis.2007.03.002
CitationsScopus - 31
Co-authorsLisa Lincz, John Attia, Rodney Scott, Chris Levi
2007Hubbard IJ, Parsons MW, 'The conventional care of therapists as acute stroke specialists: A case study', International Journal of Therapy and Rehabilitation, 14 357-362 (2007) [C1]
Co-authorsIsobel Hubbard
2007Parsons MW, Pepper EM, Bateman GA, Wang Y, Levi CR, 'Identification of the penumbra and infarct core on hyperacute noncontrast and perfusion CT', Neurology, 68 730-736 (2007) [C1]
DOI10.1212/01.wnl.0000256366.86353.ff
CitationsScopus - 80Web of Science - 65
Co-authorsChris Levi
2007Butcher KS, Lee SB, Parsons MW, Allport L, Fink J, Tress B, et al., 'Differential prognosis of isolated cortical swelling and hypoattenuation on CT in acute stroke', Stroke, 38 941-947 (2007) [C1]
DOI10.1161/01.str.0000258099.69995.b6
CitationsScopus - 33Web of Science - 28
2006Parsons MW, Barber Alan P, Davis SM, Donnan G, Phan TG, Reutens DC, et al., 'Proof of Principle Phase II MRI studies in Stroke: Sample size estimates from Dichotomous and Continuous Data', Stroke, 37 2521-2525 (2006) [C1]
DOI10.1161/01.STR.0000239696.61545.4b
2006Parsons MW, Pepper EM, Chan V, Siddique S, Rajaratnam S, Rajarabram S, et al., 'Toxic brainstem encephalopathy after artemisinin treatment for breast cancer - Reply', Annals of Neurology, 59 726-726 (2006) [C3]
Co-authorsChris Levi
2006Parsons MW, Pepper EM, Chan VWC, Siddique S, Rajaratnam S, Rajarabram S, et al., 'Reply [4] Perfusion computed tomography: prediction of final infarct extent and stroke outcome', Annals of Neurology, 59 726 (2006) [C3]
Co-authorsChris Levi
2006Butcher K, Parsons MW, Allport L, Prosser J, Tress B, Donnan G, Davis S, 'Refining and testing the PWI-DWI mismatch hypothesis', International Congress Series, 1290 56-66 (2006) [C1]
DOI10.1016/j.ics.2005.11.107
2006Pepper EM, Parsons MW, Bateman GA, Levi CR, 'CT perfusion source images improve identification of early ischaemic change in hyperacute stroke', Journal of Clinical Neuroscience, 13 199-205 (2006) [C1]
DOI10.1016/j.jocn.2005.03.030
CitationsScopus - 15Web of Science - 15
Co-authorsChris Levi
2005Yan B, Parsons MW, McKay S, Campbell D, Infeld B, Czajko R, Davis SM, 'When to measure lipid profile after stroke: A prospective serial study', Cerebrovascular Diseases, 19 234-238 (2005) [C1]
DOI10.1159/000084086
2005Davis SM, Donnan GA, Butcher KS, Parsons MW, 'Selection of thrombolytic therapy beyond 3 h using magnetic resonance imaging', Current Opinion in Neurology, 18 47-52 (2005) [C1]
DOI10.1097/00019052-200502000-00010
2005Poh-Sien L, Butcher KS, Parsons MW, Macgregor LR, Desmond P, Tess B, Davis S, 'Apparent Diffusion Coefficient Thresholds do not predict the response to Acute Stroke Thrombolysis', Stroke, 36 2626-2631 (2005) [C1]
DOI10.1161/01.STR.0000189688.95557.2b
CitationsScopus - 36Web of Science - 33
2005Parsons MW, Pepper EM, Chan V, Siddique S, Rajaratnam S, Bateman GA, Levi CR, 'Perfusion computed tomography: Prediction of final infarct extent and stroke outcome', Annals of Neurology, 58 672-679 (2005) [C1]
DOI10.1002/ana.20638
CitationsScopus - 113Web of Science - 98
Co-authorsChris Levi
2005Allport LE, Parsons MW, Butcher KS, Macgregor L, Desmond PM, Tress BM, Davis SM, 'Elevated hematocrit is associated with reduced reperfusion and tissue survival in acute stroke', Neurology, 65 1382-1387 (2005) [C1]
DOI10.1212/01.wnl.0000183057.96792.a8
2005Butcher K, Parsons MW, Macgregor LR, Barber PA, Chalk J, Bladin CF, et al., 'Refining the Perfusion-Diffusion Mismatch Hypothesis', Stroke, 36 1153-1159 (2005) [C1]
DOI10.1161/01.STR.0000166181.86928.8b
Co-authorsChris Levi
2005Prosser J, Butcher K, Allport L, Parsons MW, Macgregor L, Desmond P, et al., 'Clinical-diffusion mismatch predicts the putative penumbra with high specificity', Stroke, 36 1700-1704 (2005) [C1]
DOI10.1161/01.str.0000173407.40773.17
2004Levi CR, 'Tissue plasminogen activator (tPA) in acute ischaemic stroke: time for collegiate and consensus', Medical Journal of Australia, 180 634-636 (2004) [C3]
CitationsScopus - 3Web of Science - 6
Co-authorsChris Levi
2004Lovelock C, Parsons MW, 'Hypokalaemic paralysis revealing Sjogrens syndrome', J Clin Neurosci, 11 319-321 (2004) [C2]
CitationsScopus - 6
2004Barber PA, Parsons MW, Desmond PM, Bennett DA, Donnan GA, Tress BM, Davis SM, 'Use of PWI and DWI Measures in the Design of Proof of Concept Stroke Trials', Journal of Neuroimaging, (2004) [C1]
DOI10.1177/1051228403259879
2003Smith BJ, Donnan GA, Davis SM, Levi CR, Johnson KR, Bailey PM, et al., 'Thrombolysis for acute ischaemic stroke: Revisiting the evidence (multiple letters)', Medical Journal of Australia, 179 386-389 (2003)
CitationsScopus - 5
Co-authorsChris Levi
2003Szoeke CEI, Parsons MW, Butcher KS, Baird TA, Mitchell PJ, Fox SE, Davis SM, 'Acute stroke thrombolysis with intravenous tissue plasminogen activator in an Australian tertiary hospital', Medical Journal of Australia, 178 324-328 (2003) [C1]
2003Baird TA, Parsons MW, Phanh T, Butcher KS, Desmond PM, Tress BM, et al., 'Persistent poststroke hyperglycemia in independently associated with infarct expansion and worse clinical outcome', Department Neurology Royal Melbourne Hospital, 34 2208-2214 (2003) [C1]
DOI10.1161/01.STR.0000085087.41330.FF
2003Butcher K, Parsons MW, Baird T, Barber A, Donnan G, Desmond P, et al., 'Perfusion thresholds in acute stroke thrombolysis', Stroke, 34 2159-2164 (2003) [C1]
DOI10.1161/01.STR.0000086529.83878.A2
2003Butcher KS, Parsons MW, Davis S, Donnan G, 'PWI/DWI mismatch: Better definition required', Stroke, 34 E215-E216 (2003) [C3]
DOI10.1161/01.str.0000099066.23627.24
2003Lovelock C, Mitchel P, Brown J, Campbell D, Field P, Parsons MW, Sm D, 'Is doppler ultrasound sufficient as the sole investigation before carotid endarterectomy', Journal of Clinical Neurscience, 10 420-424 (2003) [C1]
DOI10.1016/S0967-5868(03)00081-X
2002Parsons MW, Barber PA, Davis SM, 'Relationship between severity of MR perfusion deficit and DWI lesion evolution', Neurology 2002, 58 (2002) [C3]
2002Parsons MW, Barber PA, Chalk J, Darby DG, Rose S, Desmond PM, et al., 'Diffusion and Perfusion-weighted MR imaging response to thrombolysis', Annals of Neurology, (2002) [C1]
2002Parsons MW, Barber PA, Desmond PM, Baird TA, Tress BM, Davis SM, 'Acute hyperglycaemia adversely affects stroke outcome: an MR imaging and spectroscopy study', Annals of Neurology, (2002) [C1]
2002Baird TA, Parsons MW, Butcher K, Davis SM, Colman P, Jerums G, et al., 'The influence of diabetes mellitus and hyperglycaemia on stroke incidence and outcome', J Clin Neurosci, (2002) [C1]
2002Gerraty RP, Parsons MW, Barber PA, Darby DG, Desmond PM, Tress BM, Davis SM, 'Examining the lacunar hypothesis with diffusion and perfusion MRI', Stroke, (2002) [C1]
2002Butcher KS, Parsons MW, 'Cardiac enzyme elevations after stroke: the importance of specificity', Stroke, 33 1944-1945 (2002) [C3]
2002Butcher K, Baird TA, Parsons MW, Davis SM, 'Medical management of intracerebral haemorrhage', Neurosurgery Quarterly, (2002) [C1]
2001Barter P, Best J, Boyden A, Cooper C, Gillam I, Mansfield P, et al., 'Lipid Management Guidelines 2001', Med J Aust, 175 57-88 (2001) [C2]
2001Baird AE, Dambroisa J, Janket S, Eichbaum Q, Chaves C, Silver B, et al., 'A three-item scale for the early prediction of stroke recovery', Lancet, (2001) [C1]
2001Desmond PM, Lovell AC, Rawlinson AA, Parsons MW, Barber PA, Yang Q, et al., 'The value of apparent diffusion coefficient maps in early cerebral ischemia', AJNR, (2001) [C1]
2001Parsons MW, Yang Q, Barber PA, Darby DG, Desmond PM, Gerraty RP, et al., 'Perfusion MRI maps in hyperacute stroke: relative cerebral blood flow most accurately identifies tissue destined to infarct', Stroke, (2001) [C1]
2001Gerraty RP, Parsons MW, Barber PA, Darby DG, Davis SM, 'The volume of lacunes', Stroke, 32 1937-1938 (2001) [C3]
Show 159 more journal articles

Conference (139 outputs)

YearCitationAltmetricsLink
2014Kitsos GH, Hubbard I, Kitsos AR, Parsons M, '2Up: A longitudinal study of upper limb recovery', INTERNATIONAL JOURNAL OF STROKE (2014) [E3]
Author URL
Co-authorsIsobel Hubbard
2014Campbell B, Mitchell P, Yan B, Churilov L, Ma H, Parsons M, et al., 'Extending the Time for Thrombolysis in Emergency Neurological Deficits - Intra-Arterial: The EXTEND-IA Trial', CEREBROVASCULAR DISEASES (2014) [E3]
Author URL
2014Lin L, Bivard A, Krishnamurthy V, Levi C, Parsons M, 'Comparison of Whole-Brain CTP and Limited-Coverage CTP', CEREBROVASCULAR DISEASES (2014) [E3]
Author URL
Co-authorsChris Levi
2014Ang T, Levi C, Ma H, Hsu C, Campbell B, Donnan G, et al., 'Multi-Modal CT in Acute Stroke: Wait for a Serum Creatinine Before Giving Intravenous Contrast? No!', CEREBROVASCULAR DISEASES (2014) [E3]
Author URL
Co-authorsChris Levi
2014Lin L, Bivard A, Levi C, Parsons M, 'How to Measure Cross-Modality Reperfusion with Acute CTP and 24-Hour MRP', CEREBROVASCULAR DISEASES (2014) [E3]
Author URL
Co-authorsChris Levi
2014Bivard A, Krishnamurthy V, Levi C, Mcelduff P, Miteff F, Spratt N, et al., 'Stroke Thrombolysis: Tissue Is More Important Than Time', CEREBROVASCULAR DISEASES (2014) [E3]
Author URL
Co-authorsChris Levi, Neil Spratt
2014Bivard A, Krishnamurthy V, Levi C, Mcelduff P, Miteff F, Spratt N, et al., 'Does the Presence of CTP Mismatch Predict Better Outcomes in Thrombolysis-Treated Patients?', CEREBROVASCULAR DISEASES (2014) [E3]
Author URL
Co-authorsNeil Spratt, Chris Levi
2014Bivard A, Krishnamurthy V, Levi C, Mcelduff P, Miteff F, Spratt N, et al., 'Better Stroke Outcomes Despite Worse Baseline Stroke Severity with Combined Clinical and CTP Assessment', CEREBROVASCULAR DISEASES (2014) [E3]
Author URL
Co-authorsNeil Spratt, Chris Levi
2014Sewell C, Garnett A, Marsden D, McElduff P, Parsons M, Levi C, 'Validation of the 'Hunter 8' abbreviated National Institutes of Health Scale score for pre-hospital thrombolysis eligible stroke recognition', INTERNATIONAL JOURNAL OF STROKE (2014) [E3]
Author URL
CitationsWeb of Science - 1
Co-authorsChris Levi
2014Bhaskar S, Evans M, Kitsos G, Russel M, Stanwell P, Walker R, et al., 'The influence of initial stroke severity on the likelihood of death at 90 days following acute stroke: A tertiary hospital stroke register study', INTERNATIONAL JOURNAL OF STROKE (2014) [E3]
Author URL
Co-authorsNeil Spratt, Chris Levi
2014Bivard A, Krishnamurthy V, Levi C, McElduff P, Miteff F, Spratt N, et al., 'Stroke thrombolysis: Tissue is more important than time', INTERNATIONAL JOURNAL OF STROKE (2014) [E3]
Author URL
Co-authorsChris Levi, Neil Spratt
2014Bivard A, Krishnamurthy V, Levi C, McElduff P, Miteff F, Spratt N, et al., 'Does the presence of CTP mismatch predict better outcomes in thrombolysis-treated patients?', INTERNATIONAL JOURNAL OF STROKE (2014) [E3]
Author URL
Co-authorsChris Levi, Neil Spratt
2014Zareie H, Selmes C, Kawano H, Parsons M, Spratt N, Miteff F, et al., 'Feasibility and accuracy of fusion TCCD in monitoring acute stroke treatment', INTERNATIONAL JOURNAL OF STROKE (2014) [E3]
Author URL
Co-authorsNeil Spratt, Chris Levi
2014Lin L, Bivard A, Krishnamurthy V, Levi C, Parsons M, 'Whole-brain CT perfusion measures the acute ischaemic lesion accurately and precisely', INTERNATIONAL JOURNAL OF STROKE (2014) [E3]
Author URL
Co-authorsChris Levi
2014Bivard A, Krishnamurthy V, Levi C, McElduff P, Miteff F, Spratt N, et al., 'Better stroke outcomes despite worse baseline stroke severity - The value of a combined clinical and advanced CT selection approach to thrombolysis', INTERNATIONAL JOURNAL OF STROKE (2014) [E3]
Author URL
Co-authorsNeil Spratt, Chris Levi
2014Gunathilake R, Krishnamurthy V, Oldmedow C, Kerr E, Padmakumar C, Attia J, et al., 'Relationships between age, other predictive variables and the 90-day functional outcome after intravenous thrombolysis for acute ischemic stroke', INTERNATIONAL JOURNAL OF STROKE (2014) [E3]
Author URL
Co-authorsJohn Attia, Chris Levi, Christopher Oldmeadow
2014Yassi N, Campbell B, Desmond PM, Parsons M, Davis SM, Bivard A, 'Baseline peri-infarct n-acetylaspartic acid correlates with regional white matter atrophy after ischaemic stroke', INTERNATIONAL JOURNAL OF STROKE (2014) [E3]
Author URL
2014Kerr E, Sanson-Fisher RW, Paul CL, DEste C, Parsons M, Bladin C, et al., 'Thrombolysis ImPlementation in Stroke (TIPS): Evaluating the effectiveness of a strategy to increase the adoption of best evidence practice: An overview of data collected during the baseline period', INTERNATIONAL JOURNAL OF STROKE (2014) [E3]
Author URL
Co-authorsCatherine Deste, Rob Sanson-Fisher, Frans Henskens, Chris Levi, Chris Paul, John Attia
2014Zareie H, Selmes C, Kawano H, Parsons M, Spratt N, Miteff F, et al., 'Feasibility and accuracy of fusion TCCD in acute stroke treatment', INTERNATIONAL JOURNAL OF STROKE (2014) [E3]
Author URL
Co-authorsNeil Spratt, Chris Levi
2014Bhaskar S, Evans MK, Kitsos G, Russell M, Stanswell P, Walker R, et al., 'The influence of initial stroke severity on the likelihood of death at 90 days following acute stroke: A tertiary hospital stroke registry study.', International Journal of Stroke, Hamilton Island, Queensland (2014)
DOI10.1111/ijs.12297
Co-authorsNeil Spratt, Chris Levi
2014Kitsos, Evans MK, Kerr E, Russell M, Royan A, Kaauwai L, et al., 'Target stroke: Improving door to needle time; A quality improvement workshop', International Journal of Stroke, Sydney, Australia (2014) [E3]
2013Rennie JL, Jolly TA, Bateman GA, Michie PT, Levi CR, Parsons MW, Karayanidis F, 'Age-related decline in white matter organisation: Relationship to global cognitive changes in a longitudinal study', Frontiers in Human Neuroscience, Melbourne (2013) [E3]
DOI10.3389/conf.fnhum.2013.212.00085
Co-authorsChris Levi, Frini Karayanidis, Pat Michie
2013Bladin C, Levi C, Parsons M, 'Magnetically Enhanced Diffusion (MED) for Improved Efficacy of Thrombolytic Therapy in Acute Ischemic Stroke_A Prospective First in Man Clinical Study', STROKE, Honolulu, HI (2013) [E3]
Author URL
Co-authorsChris Levi
2013Yassi N, Campbell BC, Christensen S, Sharma G, Bivard A, Lin L, et al., 'Reduced Cerebral Blood Flow on Acute Whole Brain CT Perfusion Best Predicts Hemorrhagic Transformation', STROKE, Honolulu, HI (2013) [E3]
Author URL
Co-authorsChris Levi
2013Campbell BC, Christensen S, Yassi N, Sharma G, Bivard A, Lin L, et al., 'Comparison of Automated Whole Brain CT Perfusion Analysis with Perfusion-Diffusion MRI in Ischemic Stroke', STROKE, Honolulu, HI (2013) [E3]
Author URL
Co-authorsChris Levi
2013Bivard A, Parsons M, 'Defining Acute Ischemic Stroke Tissue Pathophysiology Using Whole Brain 320 Slice Ct Perfusion', STROKE, Honolulu, HI (2013) [E3]
Author URL
2013Bivard A, Parsons M, 'Whole Brain Perfusion In Tia', STROKE, Honolulu, HI (2013) [E3]
Author URL
2013Karayanidis F, Jolly T, Michie P, Parsons M, Levi C, Heathcote A, 'AGE-RELATED CHANGES IN WHITE MATTER IN FRONTO-PARIETAL AND FRONTO-STRIATAL TRACTS ARE ASSOCIATED WITH DISTINCT MEASURES OF COGNITIVE FLEXIBILITY', PSYCHOPHYSIOLOGY, Florence, ITALY (2013) [E3]
Author URL
Co-authorsAndrew Heathcote, Chris Levi, Frini Karayanidis, Pat Michie
2013Karayanidis F, Jolly T, Michie P, Levi C, Parsons M, Heathcote A, 'AGE-RELATED CHANGES IN WHITE MATTER IN FRONTO-PARIETAL AND FRONTO-STRIATAL TRACTS ARE ASSOCIATED WITH DISTINCT MEASURES OF COGNITIVE FLEXIBILITY', JOURNAL OF COGNITIVE NEUROSCIENCE, San Francisco, CA (2013) [E3]
Author URL
Co-authorsChris Levi, Andrew Heathcote, Pat Michie, Frini Karayanidis
2013Yassi N, Parsons MW, Donnan GA, Christensen S, Levi CR, Desmond PM, et al., 'Infarct core volume on whole brain perfusion CT is predictive of haemorrhagic transformation after stroke', CEREBROVASCULAR DISEASES (2013) [E3]
Author URL
Co-authorsChris Levi
2013Bivard A, Krishnamurthy V, Stanwell P, Levi C, Davis S, Parsons M, '3T MR Spectroscopy assessment of metabolic changes in the recently salvaged human ischemic penumbra', CEREBROVASCULAR DISEASES (2013) [E3]
Author URL
Co-authorsChris Levi
2013Meretoja A, Keshtkaran M, Tatlisumak T, Parsons MW, Davis SM, Donnan GA, Churilov L, 'Stroke thrombolysis: Save a minute - save a day', CEREBROVASCULAR DISEASES (2013) [E3]
Author URL
2013Bivard A, Stanwell P, Spratt N, Levi C, Krishnamurthy V, Davis S, Parsons M, 'Arterial spin labelling versus bolus-tracking CT and MR in hyper-acute ischemic stroke', CEREBROVASCULAR DISEASES (2013) [E3]
Author URL
Co-authorsNeil Spratt, Chris Levi
2013Marquez J, Van Vliet P, McElduff P, Lagopoulos J, Parsons M, 'Transcranial Direct Current Stimulation (tDCS): is it effective as a stroke therapy?: a systematic review', INTERNATIONAL JOURNAL OF STROKE (2013) [E3]
Author URL
Co-authorsPaulette Vanvliet, Jodie Marquez
2013Bivard A, Stanwell P, Krishnamurthy V, Levi CR, Davis SM, Parsons M, 'Automated mismatch assessment of arterial spin labeling compared to conventional bolus tracking perfusion mismatch', INTERNATIONAL JOURNAL OF STROKE (2013) [E3]
Author URL
Co-authorsChris Levi
2013Bivard A, Yassi N, Stanwell P, Krishnamurthy V, Levi CR, Davis SM, Parsons M, 'Spectroscopy of hyperperfused and mildly hypoperfused tissue following ischemic stroke', INTERNATIONAL JOURNAL OF STROKE (2013) [E3]
Author URL
Co-authorsChris Levi
2013Lillicrap T, Tahtali M, Neely A, Wang X, Levi CR, Parsons M, et al., 'Validation of a finite element model of heat transfer in the stroke-affected brain against data from humans and non-human primates', INTERNATIONAL JOURNAL OF STROKE (2013) [E3]
Author URL
Co-authorsChris Levi
2013Lillicrap T, Stanwell P, Neeman T, Parsons M, Spratt N, Levi CR, Lueck C, 'Variation in regional brain temperature as measured by MR thermography in healthy volunteers', INTERNATIONAL JOURNAL OF STROKE (2013) [E3]
Author URL
Co-authorsNeil Spratt, Chris Levi
2013Fuentes S, Sharma V, Huang Y, Lavados P, Lindley R, Pandian J, et al., 'The Enhanced Control of Hypertension ANd Thrombolysis strokE StuDy (ENCHANTED): first year experience regarding possible selection bias', INTERNATIONAL JOURNAL OF STROKE (2013) [E3]
Author URL
Co-authorsChris Levi
2013Miller J, Marquez J, Van Vliet P, Lagopoulos J, Parsons M, 'Transcranial Direct Current Stimulation: A randomised controlled trial to investigate the effects on upper limb function in chronic stroke', INTERNATIONAL JOURNAL OF STROKE (2013) [E3]
Author URL
Co-authorsPaulette Vanvliet, Jodie Marquez
2013Kitsos G, Hubbard IJ, Kitsos A, Parsons MW, 'Non-affected or less affected: What is the ipsilesional upper limb following stroke? A systematic literature review', INTERNATIONAL JOURNAL OF STROKE (2013) [E3]
Author URL
Co-authorsIsobel Hubbard
2013Bivard A, Stanwell P, Krishnamurthy V, Levi C, Davis S, Parsons M, 'Automated mismatch assessment of arterial spin labeling compared to conventional bolus tracking perfusion mismatch', International Journal of Stroke, Darwin, NT (2013) [E3]
DOI10.1111/ijs.12214Author URL
Co-authorsChris Levi
2012Marsden DL, Garnett AR, Parsons MW, Spratt NJ, Watson T, Loudfoot A, et al., 'No thrombolysis service? No worries. A controlled trial of facilitated access for rural stroke patients to a regional thrombolysis centre - The Hunter Rural PAST Protocol', Abstract E-book. 2012 European Stroke Conference, Lisbon, Portugal (2012) [E3]
Co-authorsNeil Spratt, Chris Levi
2012Hubbard IJ, Carey LM, Budd TW, Parsons MW, 'An RCT of differing intensities of early upper limb training post stroke: Evidence of neuroplastic changes in the ipsilesional SMA', Congress Handbook. 7th World Congress for Neurorehabilitation, Melbourne, VIC (2012) [E3]
Co-authorsIsobel Hubbard, Bill Budd
2012Jolly TAD, Bateman GA, Levi CR, Parsons MW, Karayanidis F, 'The relationship between arterial and venous pulsatility and microstructural white matter changes', Front. Hum. Neurosci. Conference Abstract: ACNS-2012 Australasian Cognitive Neuroscience Conference, Brisbane, Australia (2012) [E3]
Co-authorsFrini Karayanidis, Chris Levi
2012Rennie JL, Jolly TAD, Michie PT, Levi CR, Parsons MW, Lenroot R, Karayanidis F, 'Measures of white matter decline and global cognitive ability in older adults', Front. Hum. Neurosci. Conference Abstract: ACNS-2012 Australasian Cognitive Neuroscience Conference, Brisbane, Australia (2012) [E3]
Co-authorsFrini Karayanidis, Pat Michie, Chris Levi
2012Conley A, Marquez JL, Parsons MW, Fulham WR, Lagopoulos J, Karayanidis F, 'Sustained effects of anodal tDCS over the dominant motor cortex on response preparation processes', Front. Hum. Neurosci. Conference Abstract: ACNS-2012 Australasian Cognitive Neuroscience Conference, Brisbane, Australia (2012) [E3]
Co-authorsFrini Karayanidis, Jodie Marquez
2012Karayanidis F, Jolly TAD, Cooper PS, Levi CR, Parsons MW, Michie PT, 'Disruption to frontal white matter pathways on performance in the task-switching paradigm', Front. Hum. Neurosci. Conference Abstract: ACNS-2012 Australasian Cognitive Neuroscience Conference, Brisbane, Australia (2012) [E3]
Co-authorsFrini Karayanidis, Pat Michie, Chris Levi
2012Jolly TAD, Fulham WR, Michie PT, Levi CR, Parsons MW, Karayanidis F, 'Disruption to frontal white matter pathways related to performance on the stop-signal task', Front. Hum. Neurosci. Conference Abstract: ACNS-2012 Australasian Cognitive Neuroscience Conference, Brisbane, Australia (2012) [E3]
Co-authorsFrini Karayanidis, Chris Levi, Pat Michie
2012Conley A, Marquez JL, Parsons MW, Lagopoulos J, Karayanidis F, 'Effects of anodal tDCS over the primary motor cortex on response preparation and execution', Combined Abstracts of 2012 Australian Psychology Conferences, Sydney, NSW (2012) [E3]
Co-authorsFrini Karayanidis, Jodie Marquez
2012Cooper P, Jolly TAD, Michie PT, Parsons MW, Levi CR, Fulham WR, Karayanidis F, 'The role of white matter tract disruption on age-related decline in cognitive flexibility', Combined Abstracts of 2012 Australian Psychology Conferences, Sydney, NSW (2012) [E3]
Co-authorsFrini Karayanidis, Pat Michie, Chris Levi
2012Bivard A, Parsons MW, 'A new measure of acute perfusion imaging in ischemic stroke- Severity', International Journal of Stroke, Darling Harbour, Sydney (2012) [E3]
2012Campbell BCV, Christensen S, Tress BM, Desmond PM, Parsons MW, Barber PA, et al., 'Insights into the relationship of perfusion-diffusion mismatch and leptomeningeal collateral quality - Simultaneous assessment through novel visualization of perfusion imaging', International Journal of Stroke, Darling Harbour, Sydney (2012) [E3]
CitationsWeb of Science - 1
Co-authorsChris Levi
2012Thomas LH, Rivett DA, Parsons MW, Levi CR, 'Radiological features of craniocervical arterial dissection and topography of the resultant infarct: Relation with risk factors', International Journal of Stroke, Darling Harbour, Sydney (2012) [E3]
Co-authorsChris Levi, Darren Rivett, Lucy Thomas
2012Bivard A, Parsons MW, 'Defining acute ischemic stroke tissue pathophysiology using 320 slice CT perfusion', International Journal of Stroke, Darling Harbour, Sydney (2012) [E3]
Co-authorsChris Levi
2012Karayanidis F, Jolly TAD, Bateman GA, Michie PT, Parsons MW, Levi CR, 'Structural brain changes associated with pulse-wave encephalopathy', International Journal of Stroke, Darling Harbour, Sydney (2012) [E3]
Co-authorsFrini Karayanidis, Pat Michie, Chris Levi
2012Karayanidis F, Cooper P, Jolly TAD, Michie PT, Parsons MW, Levi CR, Fulham WR, 'The influence of white matter changes with ageing and mild ischemic attacks on cognitive flexibility', International Journal of Stroke, Darling Harbour, Sydney (2012) [E3]
Co-authorsFrini Karayanidis, Pat Michie, Chris Levi
2012Hubbard IJ, Carey L, Budd TW, Parsons MW, 'Brain activation and upper limb recovery post stroke: A systematic literature review', International Journal of Stroke, Darling Harbour, Sydney (2012) [E3]
CitationsWeb of Science - 1
Co-authorsBill Budd, Isobel Hubbard
2012Campbell B, Donnan G, Davis S, Ma H, Christensen S, Connelly A, et al., 'EXtending the time for Thombolysis in Emergency Neurological Deficits - Intra-Arterial: The EXTEND Trial progress', International Journal of Stroke, Darling Harbour, Sydney (2012) [E3]
2012Campbell B, Mitchell P, Yan B, Churilov L, Ma H, Parsons MW, et al., 'EXtending the time for Thombolysis in Emergency Neurological Deficits - Intra-Arterial: the EXTEND-IA Trial rationale and protocol', International Journal of Stroke, Darling Harbour, Sydney (2012) [E3]
2012Bivard A, Stanwell PT, Parsons MW, 'MR Spectroscopy: Bio-makers for post stroke recovery', International Journal of Stroke, Darling Harbour, Sydney (2012) [E3]
2012Garnett AR, Marsden DL, Parsons MW, Spratt NJ, Watson T, Loudfoot AR, et al., 'The Hunter Rural PAST Protocol: An innovative and effective partnership between ambulance and a regional thrombolysis centre to facilitate access for rural stroke patient to thrombolysis', International Journal of Stroke, Darling Harbour, Sydney (2012) [E3]
Co-authorsChris Levi, Neil Spratt
2012Lin L, Bivard A, Kemp D, Parsons MW, Levi CR, 'Comparison of perfusion CT and MR in hyperacute stroke', International Journal of Stroke, Sydney, N.S.W. (2012) [E3]
Co-authorsChris Levi
2012Bivard A, Levi CR, Parsons MW, 'Assessing the variability of CTP post processing techniques to define the acute infarct core and penumbra', Abstract E-book. 2012 European Stroke Conference, Lisbon, Portugal (2012) [E3]
Co-authorsChris Levi
2012Bivard A, Stanwell PT, Levi CR, Parsons MW, 'Clinical utility of subacute Arterial Spin Labelling in stroke', Abstract E-book. 2012 European Stroke Conference, Lisbon, Portugal (2012) [E3]
Co-authorsChris Levi
2011Maguire JM, Holliday EG, Sturm J, Golledge J, Lewis M, Koblar S, et al., 'Australian stroke genetics collaborative: Genetic associations with ischaemic stroke functional outcome', International Journal of Stroke, Adelaide, SA (2011) [E3]
Co-authorsJohn Attia, Rodney Scott, Chris Levi, Pablo Moscato, Lisa Lincz, Jane Maguire, Liz Holliday
2011Bivard A, Parsons MW, 'The clinical reliability and predictability of acute CTP', International Journal of Stroke, Adelaide, SA (2011) [E3]
2011Bivard A, Parsons MW, 'Validation of arterial spin labeling in 24-hour stoke patients', International Journal of Stroke, Adelaide, SA (2011) [E3]
2011Bivard A, Spratt NJ, Levi CR, Parsons MW, 'CTP thresholds to detect acute ischeamic stroke tissue pathophysiology', International Journal of Stroke, Adelaide, SA (2011) [E3]
Co-authorsNeil Spratt, Chris Levi
2011Beath A, Bivard A, McElduff P, Parsons MW, Levi CR, 'Clinical predictors of outcome in acute ischaemic stroke patients treated with intravenous tissue plasminogen activator (tPA)', International Journal of Stroke, Adelaide, SA (2011) [E3]
Co-authorsChris Levi
2011Campbell B, Christensen S, Levi CR, Desmond P, Donnan G, Davis G, Parsons MW, 'Comparison of CT perfusion to multimodal MRI in ischemic stroke', International Journal of Stroke, Adelaide, SA (2011) [E3]
Co-authorsChris Levi
2011Chen X, Huang Y, Wang J, Heeley E, Delcourt C, Lindley R, et al., 'The Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT2): Progress and quality control update', International Journal of Stroke, Adelaide, SA (2011) [E3]
2011Fuentes S, Huang Y, Wang J, Sharma V, Nguyen HT, Pandian J, et al., 'The Enhanced Control of Hypertension ANd Thrombolysis strokE StuDy (ENCHANTED): Part B - Rationale for a trial of early intensive blood pressure lowering after use of rtPA', International Journal of Stroke, Adelaide, SA (2011) [E3]
Co-authorsChris Levi
2011Tu H, Campbell B, Christensen S, Churilov L, Parsons MW, De Silva D, et al., 'More severe hypoperfusion leads to greater infarct growth and worse stroke outcome in atrial fibrillation', International Journal of Stroke, Adelaide, SA (2011) [E3]
2011Russell ML, Evans MK, Royan AT, Magin PJ, Lasserson D, Attia JR, et al., 'Referral and triage of patients with TIAs to an acute access clinic: Risk-stratification performance in an Australian setting', International Journal of Stroke, Adelaide, SA (2011) [E3]
Co-authorsChris Levi, Neil Spratt, John Attia, Parker Magin
2011O'Brien W, Chung K, Levi CR, Spratt NJ, Parsons MW, 'Comparative study of Multimodal Computed Tomography (MdCT) and Magnetic resonance imaging (MRI) in Transient ischaemic attack and minor stroke patient', International Journal of Stroke, Adelaide, SA (2011) [E3]
Co-authorsChris Levi, Neil Spratt
2011Menon B, O'Brien W, Bivard A, Levi CR, Spratt NJ, Parsons MW, 'Detailed anatomic and physiologic assessment of leptomeningeal collaterals in acute ischemic stroke patients using dynamic time resolved 320 slice CT angiography', International Journal of Stroke, Adelaide, SA (2011) [E3]
Co-authorsNeil Spratt, Chris Levi
2011Hata J, Arima H, Delcourt C, Heeley E, Huang Y, Staph C, et al., 'Determinants of presenting blood pressure in acute intracerebral haemorrhage: Data from 1000 INTERACT subjects', International Journal of Stroke, Adelaide, SA (2011) [E3]
2011Leroux M, Delcourt C, Heeley E, Huang Y, Stapf C, Lindley R, et al., 'The main intensive blood pressure reduction in acute cerebral haemorrhage trial (INTERACT2): Progress update and future expectations on the largest clinical trial in ICH', International Journal of Stroke, Adelaide, SA (2011) [E3]
2011Hunter AJ, Snodgrass SN, Quain DA, Parsons MW, Levi CR, 'Orthostatic variation in transcranial Doppler measured cerebral blood flow velocity 24 hours post acute ischaemic stroke', International Journal of Stroke, Adelaide, SA (2011) [E3]
Co-authorsChris Levi, Suzanne Snodgrass
2011Lillicrap T, Jyoti R, Levi CR, Parsons MW, Spratt NJ, Stanwell P, Lueck C, 'Temperature measurements using MR spectroscopy: Validation and calibration in healthy volunteers', International Journal of Stroke, Adelaide, SA (2011) [E3]
Co-authorsChris Levi, Neil Spratt
2011Campbell BC, Christensen S, Levi CR, Desmond PM, Donnan GA, Davis SM, Parsons MW, 'Predicting infarct core using CT perfusion - comparison of CT perfusion parameters to concurrent diffusion MRI', Stroke, Los Angeles, CA (2011) [E3]
Co-authorsChris Levi
2011Campbell BC, Purushotham A, Christensen S, Desmond PM, Nagakane Y, Parsons MW, et al., 'The acute diffusion lesion reliably represents infarct core: Clinically relevant reversibility is rare', Stroke, Los Angeles, CA (2011) [E3]
CitationsWeb of Science - 1
2011Menon BK, O'Brien W, Bivard A, Levi CR, Spratt NJ, Parsons MW, 'Anatomic and physiologic assessment of leptomeningeal collaterals in acute ischemic stroke patients using dynamic time resolved 320 slice CT angiography', Stroke, Ottawa, Canada (2011) [E3]
Co-authorsChris Levi, Neil Spratt
2011Bivard A, Levi CR, Spratt NJ, Parsons MW, 'Delayed perfusion predicts the volume of the perfusion lesion', Stroke, Los Angeles, CA (2011) [E3]
Co-authorsNeil Spratt, Chris Levi
2011Tu HT, Campbell BC, Christensen S, De Silva DA, Parsons MW, Churilov L, et al., 'Worse stroke outcome in atrial fibrillation links to more severe hypoperfusion', Stroke, Los Angeles, CA (2011) [E3]
CitationsWeb of Science - 1
2011Christensen S, Campbell B, Parsons MW, De Silva DA, Ebinger M, Butcher K, et al., 'High tmax values on perfusion MRI often reflect low CBV - A pathophysiological link between the malignant perfusion profile and poor outcome?', Stroke, Los Angeles, CA (2011) [E3]
CitationsWeb of Science - 1
Co-authorsChris Levi
2011Campbell BC, Tu HT, Christensen S, Desmond PM, Levi CR, Bladin CF, et al., 'Diffusion imaging 24 hours after stroke onset accurately represents final infarct volume', Stroke, Los Angeles (2011) [E3]
Co-authorsChris Levi
2011Frith JLT, Hubbard IJ, Parsons MW, Vyslysel G, Burgman I, James CL, 'Shifting Gears: Resuming driving after stroke', Proceedings of the 24th Occupational Therapy Australia National Conference, Gold Coast, QLD (2011) [E3]
Co-authorsIsobel Hubbard, Carole James
2011Bivard A, Spratt NJ, Levi CR, Parsons MW, 'Perfusion CT predicts subsequent tissue and clinical outcome in hyperacute ischemic stroke', Cerebrovascular Diseases, Hamburg, Germany (2011) [E3]
Co-authorsNeil Spratt, Chris Levi
2011Campbell BCV, Christensen S, Levi CR, Desmond PM, Donnan GA, Davis SM, Parsons MW, 'Predicting infarct core using CT perfusion - Cerebral blood flow thresholds perform best', Cerebrovascular Diseases, Hamburg, Germany (2011) [E3]
Co-authorsChris Levi
2011Hata J, Arima H, Delcount C, Heeley E, Huang Y, Stapf C, et al., 'Determinants of hypertensive response in acute intracerebral haemorrhage: Data from 1000 infarct subjects', Cerebrovascular Diseases, Hamburg, Germany (2011) [E3]
2011Marsden DL, Garnett AR, Watson T, McElduff P, Levi CR, Parsons MW, 'In the field stroke assessment tool for paramedics: The 'Hunter 8'', Cerebrovascular Diseases, Hamburg, Germany (2011) [E3]
Co-authorsChris Levi
2011Parsons MW, Bivard A, Campbell B, Chong KK, Miteff F, Bladin C, et al., 'Tenecteplase versus alteplase for acute ischaemic stroke: An imaging based efficacy trial', Cerebrovascular Diseases, Hamburg, Germany (2011) [E3]
Co-authorsChris Levi
2010Perez De La Ossa N, Chandra RV, Campbell BCV, Christensen S, Collins M, Parsons MW, et al., 'Leukoaraiosis is not an independent risk factor for parenchymal hemorrhage after thrombolysis', Cerebrovascular Diseases: European Stroke Conference, Barcelona, Spain (2010) [E3]
Co-authorsChris Levi
2010McVerry F, Levi CR, Muir KW, Parsons MW, 'Detection of penumbra and arterial occlusions using multimodal CT - where should therapy be targeted?', Cerebrovascular Diseases: European Stroke Conference, Barcelona, Spain (2010) [E3]
Co-authorsChris Levi
2010Levi CR, Chambers BR, Young D, Stork J, Abbott A, Wlodarczyk JH, et al., 'The efficacy and safety of 10% dextran 40 in the prevention of stroke complicating carotid endarterectomy - the dextran in carotid endarterectomy (DICE) trial', Cerebrovascular Diseases: European Stroke Conference, Barcelona, Spain (2010) [E3]
Co-authorsChris Levi
2010Hubbard IJ, Parsons MW, Carey LM, 'Translating task-specific, upper limb evidence into stroke recovery intervention and clinical practice', Cerebrovascular Diseases: European Stroke Conference, Barcelona, Spain (2010) [E3]
Co-authorsIsobel Hubbard
2010Hubbard IJ, Budd TW, Carey LM, McElduff P, Levi CR, Parsons MW, 'Intensive behavioural upper limb training in acute stroke: an RCT of functional outcomes and brain reorganisation', Cerebrovascular Diseases: European Stroke Conference, Barcelona, Spain (2010) [E3]
Co-authorsIsobel Hubbard, Bill Budd, Chris Levi
2010Campbell BCV, Costello C, Christensen S, Ebinger M, Parsons MW, Desmond PM, et al., 'Acute infarct hyperintensity is almost universal beyond 3 hours and does not predict hemorrhagic transformation', Cerebrovascular Diseases: European Stroke Conference, Barcelona, Spain (2010) [E3]
Co-authorsChris Levi
2010Campbell BCV, Christensen S, Tu H, Desmond PM, Levi CR, Bladin CF, et al., 'Diffusion imaging 24 hours after stroke onset accurately represents final infarct volume', Cerebrovascular Diseases: European Stroke Conference, Barcelona, Spain (2010) [E3]
Co-authorsChris Levi
2010Campbell BCV, Christensen S, Desmond PM, Parsons MW, Barber PA, De Silva DA, et al., 'Major infarct growth beyond 6 hours is associated with collateral circulation failure', Cerebrovascular Diseases: European Stroke Conference, Barcelona, Spain (2010) [E3]
Co-authorsChris Levi
2010Bivard A, McElduff P, Spratt NJ, Levi CR, Parsons MW, 'Validating perfusion-computed tomography in defining extent of irreversible brain ischemia', Circulation, Beijing (2010) [E3]
Co-authorsNeil Spratt, Chris Levi
2010Lillicrap T, Stanwell P, Parsons MW, Spratt NJ, Hudson S, Levi CR, 'MR spectroscopy in brain temperature measurement and application to induced hypothermia therapy', Circulation, Beijing (2010) [E3]
Co-authorsChris Levi, Neil Spratt
2010Tu HT, Campbell BC, Christensen S, Butcher KS, Collins M, Parsons MW, et al., 'The Effects of Atrial Fibrillation on Infarct Evolution and Outcome', STROKE, San Antonio, TX (2010) [E3]
Author URL
CitationsWeb of Science - 1
Co-authorsChris Levi
2010Christensen S, Parsons MW, De Silva DA, Ebinger M, Butcher K, Fink J, et al., 'Testing the mismatch hypothesis in the randomized EPITHET data set: The effect of treatment, mismatch and their interaction on infarct growth', Stroke, San Antonio, Texas (2010) [E3]
CitationsWeb of Science - 3
Co-authorsChris Levi
2010Bivard A, McElduff P, Levi CR, Spratt NJ, Parsons MW, 'Defining the extent of irreversible brain ischemia using perfusion computed tomography', Stroke, San Antonio, Texas (2010) [E3]
CitationsWeb of Science - 1
Co-authorsNeil Spratt, Chris Levi
2010Campbell BC, Christensen S, Parsons MW, Desmond PM, Barber PA, Butcher KS, et al., 'Very low cerebral blood volume predicts hemorrhagic transformation better than diffusion lesion volume in acute ischemic stroke', Stroke, San Antonio, Texas (2010) [E3]
CitationsWeb of Science - 1
Co-authorsChris Levi
2010Lillicrap TP, Hudson S, Stanwell P, Parsons MW, Spratt NJ, Levi CR, 'MR spectroscopy and diffusion-weighted MRI can accurately measure both reduced and increased brain temperature', Stroke, San Antonio, Texas (2010) [E3]
Co-authorsNeil Spratt, Chris Levi
2009McLeod DD, Spratt NJ, Levi CR, Beautement S, Roworth B, Buxton D, et al., 'Experimental validation of perfusion computed tomography in acute middle cerebral artery occlusion', ACBRC 2009 Abstracts, Tianjin, China (2009) [E3]
Co-authorsNeil Spratt, Damian Mcleod, Chris Levi
2009McLeod DD, Parsons MW, Levi CR, Beautement S, Roworth B, Buxton D, et al., 'An experimental model to investigate CT brain perfusion after stroke', ANS 2009 Abstracts: Posters, Canberra, ACT (2009) [E3]
Co-authorsNeil Spratt, Damian Mcleod, Chris Levi
2009Butcher K, Christensen S, Parsons MW, De Silva D, Ebinger M, Levi CR, et al., 'Post-treatment blood pressure control predicts thrombolysis related hemorrhagic transformation', Stroke, San Diego, CA (2009) [E3]
DOI10.1161/strokeaha.108.000015
CitationsWeb of Science - 1
Co-authorsChris Levi
2009Christensen S, Parsons MW, De Silva D, Ebinger M, Butcher K, Fink J, et al., 'Optimising MR criteria for penumbral selection trials', Stroke, San Diego, CA (2009) [E3]
DOI10.1161/strokeaha.108.000015
CitationsWeb of Science - 6
Co-authorsChris Levi
2009Tan A, Coughlan K, Bray J, Parsons MW, Bladin C, 'CT angiography and CT perfusion: Single or dual imaging targets: Which is better for stroke thrombolysis?', Stroke, San Diego, CA (2009) [E3]
DOI10.1161/strokeaha.108.000015
2009McLeod DD, Spratt NJ, Levi CR, Beautement S, Roworth B, Buxton D, et al., 'Perfusion computed tomography for acute stroke: A model for experimental validation', Cerebrovascular Diseases, Stockholm, Sweden (2009) [E3]
DOI10.1159/000221776
Co-authorsNeil Spratt, Chris Levi, Damian Mcleod
2009Brekenfeld C, De Silva DA, Christensen S, Churilov L, Parsons MW, Levi CR, et al., 'Dual target (mismatch and vessel obstruction) at baseline MRI does not improve stroke patient selection for thrombolysis 3-6 h', Cerebrovascular Diseases, Stockholm, Sweden (2009) [E3]
DOI10.1159/000221772
Co-authorsChris Levi
2009Butcher K, Christensen S, Parsons MW, De Silva D, Ebinger M, Levi CR, et al., 'Hemorrhagic transformation in the echoplanar imaging thrombolysis evaluation trial (EPITHET) is predicted by post-treatment blood pressure control and infarct volume', Cerebrovascular Diseases, Stockholm, Sweden (2009) [E3]
DOI10.1159/000221772
Co-authorsChris Levi
2009Campbell BCV, Christensen S, Butcher KS, Gordon I, Parsons MW, Desmond PM, et al., 'Very low cerebral blood volume (VLCBV) predicts hemorrhagic transformation better than DWI volume in acute ischemic stroke', Cerebrovascular Diseases, Stockholm, Sweden (2009) [E3]
DOI10.1159/000221773
Co-authorsChris Levi
2009Tan A, Bladin CF, Parsons MW, Coughlan K, Bray JE, 'Patient selection for stroke thrombolysis based on CT angiography and/or CT perfusion: 'Single' or 'dual' target CT imaging', Cerebrovascular Diseases, Stockholm, Sweden (2009) [E3]
DOI10.1159/000221780
2009Tan A, Parsons MW, Bray JE, Bladin CF, 'TIMI grading of cerebral vascular occlusion: Is it reliable?', Cerebrovascular Diseases, Stockholm, Sweden (2009) [E3]
DOI10.1159/000221779
2008Budd TW, Parsons MW, Hubbard IJ, Carey L, Levi CR, 'A longitudinal fMRI study of cortical sensorimotor reorganization in stroke recovery', NeuroImage, Melbourne, VIC (2008) [E3]
Co-authorsBill Budd, Chris Levi, Isobel Hubbard
2008Hubbard IJ, Budd TW, Parsons MW, 'Arm function, fMRI and early reorganisation mapping in stroke (AFfERMS): Findings from the pilot phase', Internal Medicine Journal, Sydney, NSW (2008) [E3]
DOI10.1111/j.1445-5994.2008.01755_7.x
Co-authorsIsobel Hubbard, Bill Budd
2008Miteff F, Parsons MW, Bateman GA, Spratt NJ, Levi CR, 'Does collateral vessel status on CT angiography add to perfusion CT in the prediction of outcome after acute ischaemc stroke?', Internal Medicine Journal, Sydney, NSW (2008) [E3]
DOI10.1111/j.1445-5994.2008.01755_7.x
Co-authorsChris Levi, Neil Spratt
2008Tan A, Coughlan K, Bray J, Parsons MW, Bladin C, 'Is CT dual target imaging a valid basis for stroke thrombolysis?', Internal Medicine Journal, Sydney, NSW (2008) [E3]
DOI10.1111/j.1445-5994.2008.01755_7.x
2008Christensen S, Parsons MW, De Silva DA, Ebinger M, Butcher K, Fink J, et al., 'Optimizing mismatch definitions in acute stroke MRI: An epithet post hoc study', Internal Medicine Journal, Sydney, NSW (2008) [E3]
DOI10.1111/j.1445-5994.2008.01755_7.x
Co-authorsChris Levi
2008Hubbard R, Day K, Baker K, Parsons MW, 'Assessment of the upper limb in acute stroke: The validity of the hierarchal scoring method for the motor assessment scale', Internal Medicine Journal, Sydney, NSW (2008) [E3]
DOI10.1111/j.1445-5994.2008.01755_7.x
2008Hubbard IJ, Carey L, Parsons MW, 'The evidence concerning task-specific therapy for upper limb function: A literature review', Internal Medicine Journal, Sydney, NSW (2008) [E3]
DOI10.1111/j.1445-5994.2008.01756.x
Co-authorsIsobel Hubbard
2008Selmes C, Levi CR, Parsons MW, Miteff F, 'The incidence of anterior cerebral artery flow reversal in high-grade internal carotid artery stenotic disease or occlusion', Internal Medicine Journal, Sydney, NSW (2008) [E3]
DOI10.1111/j.1445-5994.2008.01756.x
Co-authorsChris Levi
2008Prosser JF, Allport L, Butcher K, Parsons MW, Desmond P, Tress B, Davis SM, 'The influence of ischemic stroke subtype on infarct expansion, penumbral fate and reperfusion', Stroke, New Orleans, LA (2008) [E3]
2008Wang JG, Anderson C, Huang YN, Arima H, Neal B, Peng B, et al., 'The intensive blood pressure reduction in acute cerebral haemorrhage trial (INTERACT): Results of the vanguard phase', Journal of Hypertension. Supplement, Berlin, Germany (2008) [E3]
2008Christensen S, Parsons MW, De Silva D, Ebinger M, Butcher K, Fink J, Davis S, 'Optimal mismatch definitions for detecting treatment response in acute stroke', Cerebrovascular Diseases, Nice, France (2008) [E3]
DOI10.1159/000132088
2008Desilva DA, Ebinger M, Christensen S, Levi CR, Parsons MW, Peeters A, et al., 'The impact of diabetes and admission in blood glucose on outcomes in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET)', Cerebrovascular Diseases, Nice, France (2008) [E3]
DOI10.1159/000132093
Co-authorsChris Levi
2008Ebinger M, Christensen S, Desilva DA, Parsons MW, Levi CR, Peeters A, et al., 'Expediting MRI-based proof of concept stroke trials using an earlier primary endpoint', Cerebrovascular Diseases, Nice, France (2008) [E3]
DOI10.1159/000132088
Co-authorsChris Levi
2007Maguire J, Sturm J, Attia JR, Whyte S, Bisset L, Lincz L, et al., 'A case-control genetic association study to examine platelet glycoprotein polymorphisms and ischaemic stroke risk', Internal Medicine Journal, Perth, Australia (2007) [E3]
Co-authorsLisa Lincz, John Attia, Chris Levi
2007Butcher K, Parsons MW, Allport L, Lee SB, Barber PA, Tress B, et al., 'Standardizing quantitative and qualitative perfusion-diffusion mismatch assessment', Stroke (Volume 38, Issue 2), San Francisco (2007) [E3]
2005Selmes C, Evans MK, Levi C, Parsons M, Royan A, Russell M, et al., 'PREVALENCE OF INTRACRANIAL LARGE ARTERY DISEASE IN THE HUNTER REGION', Internal Medicine Journal, Hobart Australia (2005)
Co-authorsChris Levi
2005Evans MK, russell M, royan A, moore A, parsons M, levi C, 'THE ACUTE STROKE NURSE: AN INTEGRAL PART OF THE STROKE TEAM', Internal Medicine Journal, Hobart Australia (2005)
Co-authorsChris Levi
2004Butcher KS, Macgregor L, Parsons MW, Barber PA, Levi C, Chalk J, et al., 'Multiple definitions of PWI-DWI mismatch reliably predict infarct growth', STROKE, Vancouver, CANADA (2004)
Author URL
CitationsWeb of Science - 2
2004Wang Y, Levi CR, Parsons MW, Selmes CM, Evans M, Royan A, et al., 'Predictors of in-hospital Neurological Deterioration in Acute Ischaemic Stroke', Predictors of in-hospital Neurological Deterioration in Acute Ischaemic Stroke, Sydney Australia (2004) [E3]
Co-authorsChris Levi
Show 136 more conferences

Other (2 outputs)

YearCitationAltmetricsLink
2013 'Review of Stroke Thrombolytics', ( issue.2 pp.90-98): Korean Stroke Society (2013)
Author URL
2013 'Perfusion Patterns of Ischemic Stroke on Computed Tomography Perfusion', ( issue.3 pp.164-173): Korean Stroke Society (2013)
Author URL
Edit

Grants and Funding

Summary

Number of grants46
Total funding$11,931,980

Click on a grant title below to expand the full details for that specific grant.


20153 grants / $6,206,616

Tenecteplase versus Alteplase for Stroke Thrombolysis Evaluation (TASTE) Trial$3,989,898

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Mark Parsons, Conjoint Professor Chris Levi, Doctor Patrick McElduff, Professor Richard Lindley, Professor Patricia Desmond, Professor Gregory Albers, Professor Werner Hacke, Professor Hugh Markus, Dr Bruce Campbell, Professor Thanh Phan
SchemeProject Grant
RoleLead
Funding Start2015
Funding Finish2015
GNoG1400012
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Centre for Research Excellence in Stroke Rehabilitation and Brain Recovery$1,108,359

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamAssociate Professor Julie Bernhardt, Professor Michael Nilsson, Dr Leeanne Carey, Professor Paulette Van Vliet, Dr Dominique Cadilhac, Professor Christopher Bladin, Professor Sandy Middleton, Professor Geoff Donnan, Professor Mark Parsons, Conjoint Professor Chris Levi
SchemeCentres of Research Excellence (CRE) - Centres of Clinical Research Excellence
RoleInvestigator
Funding Start2015
Funding Finish2015
GNoG1401448
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Centre for Research Excellence in Stroke Rehabilitation and Brain Recovery$1,108,359

Funding body: University of Melbourne

Funding bodyUniversity of Melbourne
Project TeamAssociate Professor Julie Bernhardt, Professor Michael Nilsson, Dr Leeanne Carey, Professor Paulette Van Vliet, Dr Dominique Cadilhac, Professor Christopher Bladin, Professor Sandy Middleton, Professor Geoff Donnan, Professor Mark Parsons, Conjoint Professor Chris Levi
SchemeShared
RoleInvestigator
Funding Start2015
Funding Finish2015
GNoG1401448
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

20147 grants / $1,062,000

Tenecteplase versus Alteplase for Stroke Thrombolysis Evaluation (TASTE) Trial$640,000

Funding body: National Heart Foundation of Australia

Funding bodyNational Heart Foundation of Australia
Project TeamProfessor Mark Parsons
SchemeFuture Leader Fellowship
RoleLead
Funding Start2014
Funding Finish2014
GNoG1300638
Type Of FundingAust Competitive - Non Commonwealth
Category1NS
UONY

Tenecteplase versus Alteplase for Stroke Thrombolysis Evaluation (TASTE) trial$300,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamProfessor Mark Parsons
SchemeProject Grant
RoleLead
Funding Start2014
Funding Finish2014
GNoG1400615
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

Neuroimaging Biomarkers of Recovery: Longitudinal Imaging Study in the rehabilitation Phase post-Acute Ischemic Stroke (NEUROLISS)$50,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Andrew Bivard, Professor Mark Parsons, Conjoint Professor Chris Levi
SchemeProject Grant
RoleInvestigator
Funding Start2014
Funding Finish2014
GNoG1401437
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

Mapping whole-brain metabolic networks$25,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Renate Thienel, Associate Professor Frini Karayanidis, Doctor Juanita Todd, Associate Professor Peter Stanwell, Professor Mark Parsons, Conjoint Professor Chris Levi
SchemeProject Grant
RoleInvestigator
Funding Start2014
Funding Finish2014
GNoG1301285
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

Individually tailoring stroke rehabilitation using advanced imaging$22,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Andrew Bivard, Professor Mark Parsons
SchemeProject Grant
RoleInvestigator
Funding Start2014
Funding Finish2014
GNoG1401506
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

Directors Award for Mid-Career Research$15,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamProfessor Mark Parsons
SchemeProject Grant
RoleLead
Funding Start2014
Funding Finish2014
GNoG1401398
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

Tenecteplase versus Alteplase for Stroke Thrombolysis Evaluation (TASTE) Trial$10,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Mark Parsons, Conjoint Professor Chris Levi, Doctor Patrick McElduff
SchemeNear Miss Grant
RoleLead
Funding Start2014
Funding Finish2014
GNoG1301401
Type Of FundingInternal
CategoryINTE
UONY

20132 grants / $103,000

Greater Charitable Foundation Fellows in Stroke Research$100,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Neil Spratt, Professor Mark Parsons, Conjoint Professor Chris Levi
SchemeStroke Research Project Grant
RoleInvestigator
Funding Start2013
Funding Finish2013
GNoG1300508
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

The role of brain vascular flow and white matter lesions in the decline of cognitive ability in older adults$3,000

Funding body: National Stroke Foundation

Funding bodyNational Stroke Foundation
Project TeamAssociate Professor Frini Karayanidis, Professor Mark Parsons, Ms Jaime Rennie
SchemeHonours Grant
RoleInvestigator
Funding Start2013
Funding Finish2013
GNoG1201085
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

20127 grants / $733,367

Cognitive flexibility from adolescence to senescence: Variability associated with cognitive strategy and brain connectivity$387,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamAssociate Professor Frini Karayanidis, Associate Professor Birte Forstmann, Professor Rhoshel Lenroot, Professor Mark Parsons, Emeritus Professor Patricia Michie, Associate Professor Natalie Phillips, Associate Professor Eric-Jan Wagenmakers
SchemeDiscovery Projects
RoleInvestigator
Funding Start2012
Funding Finish2012
GNoG1100074
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Tomago Aluminium$26,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamAssociate Professor Frini Karayanidis, Conjoint Associate Professor Grant Bateman, Professor Mark Parsons, Emeritus Professor Patricia Michie, Mr Todd Jolly, Conjoint Professor Chris Levi, Ms Jaime Rennie
SchemeProject Grant
RoleInvestigator
Funding Start2012
Funding Finish2012
GNoG1200517
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Experimental brain imaging to investigate novel protective mechanisms of short duration body cooling after stroke$20,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Damian McLeod, Doctor Neil Spratt, Professor Mark Parsons, Conjoint Professor Chris Levi
SchemeProject Grant
RoleInvestigator
Funding Start2012
Funding Finish2012
GNoG1101116
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Transcranial Direct Current Stimulation (tDCS): A new modality in stroke rehabilitation$17,367

Funding body: National Stroke Foundation

Funding bodyNational Stroke Foundation
Project TeamMrs Jodie Marquez, Professor Mark Parsons, Associate Professor Jim Lagopoulos, Associate Professor Frini Karayanidis, Professor Paulette Van Vliet
SchemeResearch Grant
RoleInvestigator
Funding Start2012
Funding Finish2012
GNoG1101038
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

Beyond Perfusion: MRS to Characterise Metabolic Changes in the Ischaemic Brain$16,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamProfessor Mark Parsons, Associate Professor Peter Stanwell
SchemeStroke Research Project Grant
RoleLead
Funding Start2012
Funding Finish2012
GNoG1101119
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

2011 Awards for Research Excellence - Shared Account$4,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Mike Calford, Professor Mark Parsons, Doctor Juanita Todd, Doctor Robert Imre, Doctor Michael Ondaatje, Conjoint Professor Dmitri Kavetski
SchemeAward for Research Excellence
RoleInvestigator
Funding Start2012
Funding Finish2012
GNoG1200056
Type Of FundingInternal
CategoryINTE
UONY

20114 grants / $1,145,824

Implementation of quality use of advanced CT imaging in acute stroke$1,075,461

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Mark Parsons, Conjoint Professor Chris Levi, Professor Geoff Donnan, Professor Stephen Davis, Professor John Attia, Professor Christopher Bladin, Mr Qing Yang, Associate Professor Peter Mitchell, Associate Professor Stacy Goergen, Professor Ramamohanarao Kotagiri
SchemePartnership Projects
RoleLead
Funding Start2011
Funding Finish2011
GNoG1000535
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Relationships between white matter lesions and cognitive and motor functioning in patients with minor ischaemic stroke: A structural and functional brain imaging study - RhD 2yr$40,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamMr Todd Jolly, Associate Professor Frini Karayanidis, Professor Mark Parsons, Conjoint Professor Chris Levi, Emeritus Professor Patricia Michie, Conjoint Associate Professor Grant Bateman, Conjoint Associate Professor Peter Schofield
SchemeResearch Higher Degree Support Grant
RoleInvestigator
Funding Start2011
Funding Finish2011
GNoG1100061
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Exploring Chronic Traumatic Encephalopathy (CTE) amongst current and former professional rugby league players$20,863

Funding body: NSW Sporting Injuries Committee

Funding bodyNSW Sporting Injuries Committee
Project TeamDoctor Frances Kay-Lambkin, Dr Andrew Gardner, Associate Professor Peter Stanwell, Conjoint Professor Chris Levi, Professor Mark Parsons
SchemeResearch & Injury Prevention Scheme
RoleInvestigator
Funding Start2011
Funding Finish2011
GNoG1100822
Type Of FundingOther Public Sector - State
Category2OPS
UONY

Transcranial Direct Current Stimulation (tDCS): The potential to improve stroke recovery$9,500

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamMrs Jodie Marquez, Professor Mark Parsons, Associate Professor Frini Karayanidis
SchemeEarly Career Researcher Grant
RoleInvestigator
Funding Start2011
Funding Finish2011
GNoG1000942
Type Of FundingInternal
CategoryINTE
UONY

20106 grants / $950,575

Evaluating the effectiveness of a strategy to increase the adoption of best evidence practice. A cluster randomised controlled trial in acute stroke care$772,950

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamLaureate Professor Robert Sanson-Fisher, Conjoint Professor Chris Levi, Associate Professor Christine Paul, Conjoint Professor Cate d'Este, Professor Mark Parsons, Professor Christopher Bladin, Professor Richard Lindley, Professor John Attia
SchemePartnership Projects
RoleInvestigator
Funding Start2010
Funding Finish2010
GNoG0189781
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Improving patient selection for acute stroke therapies - an experimental model of CT brain perfusion after stroke$50,000

Funding body: BellBerry Limited

Funding bodyBellBerry Limited
Project TeamProfessor Mark Parsons, Doctor Neil Spratt, Conjoint Professor Chris Levi, Doctor Damian McLeod, Dr Peter Stanwell
SchemeNear Miss
RoleLead
Funding Start2010
Funding Finish2010
GNoG0900222
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

Evaluating the effectiveness of a strategy to increase the adoption of best evidence practice. A cluster randomised controlled trial in acute stroke care $50,000

Funding body: Victorian Department of Health

Funding bodyVictorian Department of Health
Project TeamLaureate Professor Robert Sanson-Fisher, Conjoint Professor Chris Levi, Associate Professor Christine Paul, Conjoint Professor Cate d'Este, Professor Mark Parsons, Professor Christopher Bladin, Professor Richard Lindley, Professor John Attia
SchemeProject Grant
RoleInvestigator
Funding Start2010
Funding Finish2010
GNoG1100824
Type Of FundingOther Public Sector - State
Category2OPS
UONY

Implementation of thrombolytic therapy in acute stroke. A cluster randomised trial$30,000

Funding body: BellBerry Limited

Funding bodyBellBerry Limited
Project TeamConjoint Professor Chris Levi, Professor John Attia, Associate Professor Christine Paul, Professor Mark Parsons, Professor Christopher Bladin, Professor Richard Lindley, Conjoint Professor Cate d'Este
SchemeNear Miss
RoleInvestigator
Funding Start2010
Funding Finish2010
GNoG0900221
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

A structural and functional brain imaging study of how white matter lesions in patients with minor ischaemic strike affect cognitive and motor control processes$24,600

Funding body: Hunter Children`s Research Foundation

Funding bodyHunter Children`s Research Foundation
Project TeamAssociate Professor Frini Karayanidis, Professor Mark Parsons, Emeritus Professor Patricia Michie, Conjoint Professor Chris Levi, Ms Sharna Jamadar, Mr Matthew Hughes, Conjoint Associate Professor Peter Schofield, Conjoint Associate Professor Grant Bateman
SchemeResearch Grant
RoleInvestigator
Funding Start2010
Funding Finish2010
GNoG0900150
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

Minor stroke and Transient Ischaemic Attack pathways of care: a pilot of a cohort study based in general practice$23,025

Funding body: John Hunter Hospital Charitable Trust Fund

Funding bodyJohn Hunter Hospital Charitable Trust Fund
Project TeamProfessor Mark Parsons, Dr Daniel Lasserson, Conjoint Professor Parker Magin, Conjoint Professor Chris Levi
SchemeResearch Grant
RoleLead
Funding Start2010
Funding Finish2010
GNoG1000933
Type Of FundingOther Public Sector - State
Category2OPS
UONY

20094 grants / $761,228

Prediction of tissue fate and functional outcome in acute ischemic stroke with advanced imaging analysis - experimental validation and translational studies$686,400

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamProfessor Mark Parsons
SchemeFuture Fellowships
RoleLead
Funding Start2009
Funding Finish2009
GNoG0189746
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

A functional MRI study of upper limb therapy in community dwelling stroke survivors$41,828

Funding body: National Stroke Foundation

Funding bodyNational Stroke Foundation
Project TeamProfessor Mark Parsons, Dr Leeanne Carey, Doctor Isobel Hubbard
SchemeResearch Grant
RoleLead
Funding Start2009
Funding Finish2009
GNoG0189945
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

Establishing Computed Tomography Perfusion (CTP) imaging in an animal stroke model$20,000

Funding body: National Stroke Foundation

Funding bodyNational Stroke Foundation
Project TeamDoctor Damian McLeod, Doctor Neil Spratt, Professor Mike Calford, Conjoint Professor Chris Levi, Professor Mark Parsons
SchemeResearch Grant
RoleInvestigator
Funding Start2009
Funding Finish2009
GNoG0189942
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Towards better early imaging in stroke: Use of an experimental model to investigate CT brain perfusion$13,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Neil Spratt, Professor Mark Parsons, Doctor Damian McLeod, Conjoint Professor Chris Levi
SchemeStroke Research Project Grant
RoleInvestigator
Funding Start2009
Funding Finish2009
GNoG0189810
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

20084 grants / $482,180

Low-dose tenecteplase vs standard-dose alteplase for acute ischaemic stroke: An imaging based safety and efficacy study$335,500

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Mark Parsons, Professor Stephen Davis, Professor Christopher Bladin, Dr Romesh Markus, Associate Professor Helen Dewey, Conjoint Professor Chris Levi
SchemeProject Grant
RoleLead
Funding Start2008
Funding Finish2008
GNoG0187651
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

A randomised controlled trial of mild hypothermia in acute ischaemic stroke$117,176

Funding body: National Heart Foundation of Australia

Funding bodyNational Heart Foundation of Australia
Project TeamConjoint Professor Chris Levi, Professor Mark Parsons, Professor Christopher Bladin, Doctor Neil Spratt
SchemeGrant-In-Aid
RoleInvestigator
Funding Start2008
Funding Finish2008
GNoG0187644
Type Of FundingAust Competitive - Non Commonwealth
Category1NS
UONY

A functional MRI study of upper limb therapy in community dwelling stroke survivors$19,504

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding bodyUniversity of Newcastle - Faculty of Health and Medicine
Project TeamProfessor Mark Parsons
SchemePilot Grant
RoleLead
Funding Start2008
Funding Finish2008
GNoG0189041
Type Of FundingInternal
CategoryINTE
UONY

PULSE Early Career Researcher$10,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamProfessor Mark Parsons
SchemePULSE Early Career Researcher of the Year Award
RoleLead
Funding Start2008
Funding Finish2008
GNoG0188537
Type Of FundingDonation - Aust Non Government
Category3AFD
UONY

20072 grants / $24,539

A functional MRI and tractography study of the effect of early upper limb therapy on brain plasticity after stroke$19,039

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Bill Budd, Professor Mark Parsons, Conjoint Professor Chris Levi
SchemeProject Grant
RoleInvestigator
Funding Start2007
Funding Finish2007
GNoG0187254
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

A functional MRI study of upper limb therapy in acute stroke.$5,500

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamProfessor Mark Parsons, Doctor Bill Budd, Conjoint Professor Chris Levi
SchemeResearch Grant
RoleLead
Funding Start2007
Funding Finish2007
GNoG0187321
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

20062 grants / $142,456

A functional MRI study of upper limb therapy in acute stroke$122,474

Funding body: National Heart Foundation of Australia

Funding bodyNational Heart Foundation of Australia
Project TeamProfessor Mark Parsons, Doctor Bill Budd, Conjoint Professor Chris Levi, Doctor Isobel Hubbard
SchemeGrant-In-Aid
RoleLead
Funding Start2006
Funding Finish2006
GNoG0186201
Type Of FundingAust Competitive - Non Commonwealth
Category1NS
UONY

Supplementary oxygen for acute ischaemic stroke: an imaging-based efficacy trial (SOS trial)$19,982

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Mark Parsons, Conjoint Professor Chris Levi
SchemePilot Grant
RoleLead
Funding Start2006
Funding Finish2006
GNoG0186701
Type Of FundingInternal
CategoryINTE
UONY

20053 grants / $264,055

Acute Stroke: Imaging the Ischaemic Penumbra with Perfusion CT$239,250

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Mark Parsons, Professor Stephen Davis, Professor Brian Tress, Dr Romesh Markus, Dr Stephen Read, Conjoint Professor Chris Levi
SchemeProject Grant
RoleLead
Funding Start2005
Funding Finish2005
GNoG0183962
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Acute Stroke: Imaging the Ischaemic Penumbra with Perfusion CT$13,500

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamProfessor Mark Parsons
SchemeStroud Rodeo Committee
RoleLead
Funding Start2005
Funding Finish2005
GNoG0185103
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Neural consequences of cardiac surgery: a study using magnetic resonance measures of functional brain activation and brain metabolism$11,305

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamConjoint Associate Professor Mick Hunter, Emeritus Professor Patricia Michie, Professor Mark Parsons
SchemeProject Grant
RoleInvestigator
Funding Start2005
Funding Finish2005
GNoG0184634
Type Of FundingInternal
CategoryINTE
UONY

20042 grants / $56,140

Acute Stroke: Imaging the Ischaemic Penumbra with Perfusion CT$28,140

Funding body: Ramaciotti Foundations

Funding bodyRamaciotti Foundations
Project TeamProfessor Mark Parsons
SchemeMajor Equipment Award
RoleLead
Funding Start2004
Funding Finish2004
GNoG0184438
Type Of FundingAust Competitive - Non Commonwealth
Category1NS
UONY

Novel genetic and environmental risk factors in atherothrombosis: The role of variation in Cox-2, tpA and PAI-1 activity$28,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamConjoint Professor Chris Levi, Conjoint Professor David Henry, Dr Patricia McGettigan, Professor John Attia, Professor Mark Parsons, Dr Michael Seldon, Professor Rodney Scott
SchemeResearch Grant
RoleInvestigator
Funding Start2004
Funding Finish2004
GNoG0183749
Type Of FundingContract - Aust Non Government
Category3AFC
UONY
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Research Supervision

Current Supervision

CommencedResearch Title / Program / Supervisor Type
2014Applying Perfusion CT Detecting Lesions in Posterior Circulation Acute Stroke
General Medicine, Faculty of Health and Medicine
Principal Supervisor
2014Advanced Imaging of Stroke
General Medicine, Faculty of Health and Medicine
Principal Supervisor
2013Exploration and Application of Biochemical Markers to Aid Diagnosis and Prognosis of Neuro-Inflammation
General Medicine, Faculty of Health and Medicine
Principal Supervisor
2013Developing a Composite Computed Tomography Perfusion (CTP) / Computed Tomography Angiography (CTA) Based Revascularization-Reperfusion Scoring Based on Site of Arterial Occlusion, Lesion Location and Perfusion in Acute Ischemic Stroke Cases
General Medicine, Faculty of Health and Medicine
Principal Supervisor
2012The Effect of Transcranial Direct Current Stimulation on Motor Control
Psychology, Faculty of Science and Information Technology
Co-Supervisor
2011Whole-Brain CTP in Acute Ischemic Stroke
General Medicine, Faculty of Health and Medicine
Principal Supervisor
2011Understanding the Role of Prehospital Intubation and Advanced Brain Imaging in Patients Suffering from Severe Traumatic Brain Injury
General Medicine, Faculty of Health and Medicine
Co-Supervisor
2010Transcranial Direct Current Stimulation (tDCS): the Potential to Improve Stroke Recovery
Physiotherapy, Faculty of Health and Medicine
Principal Supervisor

Past Supervision

YearResearch Title / Program / Supervisor Type
2015Upper Limb Recovery and Brain Reorganisation Post-Stroke
General Medicine, Faculty of Health and Medicine
Principal Supervisor
2013Perfusion Imaging in Acute and Evolving Brain Ischemia
General Medicine, Faculty of Health and Medicine
Principal Supervisor
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News

Professor Brian Kelly

Mental health trailblazer

November 5, 2014

On an evening when more than 70 donor-funded grants worth $3.5 million were awarded or acknowledged, mental health trailblazer Professor Brian Kelly has been heralded as the HMRI Researcher of the Year for 2014.

Andrew Bivard

Stroke trial lures imaging research expert

February 21, 2014

The Hunter's renowned stroke research group is to be bolstered by the return of award-winning imaging expert Dr Andrew Bivard to work on acute care and rehabilitation projects.

Professors Mark Parsons

International stroke trial

December 3, 2013

A Hunter stroke drug trial that yielded rapid treatment benefits for patients will expand nationally and internationally.

Professor Mark Parsons

Professor Mark Parsons presents at the Chinese Neurological Society meeting

October 24, 2013

President of the Stroke Society of Australia (SSA) and University of Newcastle researcher, Professor Mark Parsons, was recently a keynote speaker at the Chinese Neurological Society meeting in Nanjing, China.

Professor Mark Parsons

Position

National Heart Foundation Fellow and Brawn Career Development Fellow
School of Medicine and Public Health
Faculty of Health and Medicine

Contact Details

Emailmark.parsons@newcastle.edu.au
Phone13490
Fax13488

Office

RoomJHH
BuildingJohn Hunter Hospital
LocationCallaghan
University Drive
Callaghan, NSW 2308
Australia
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