Staff Profile

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Career Summary

Biography

Dr Ong completed Bachelor of Biomedical Science (Honours) in 2008 and obtained a PhD in medical biochemistry from the University of Newcastle in 2012. He is currently a Postdoctoral Researcher at the University of Newcastle and the Hunter Medical Research Institute.

Dr Ong’s research focus has been on the investigation of the regulation of tyrosine hydroxylase in vivo. He has provided the first comprehensive analysis linking tyrosine hydroxylase phosphorylation and tyrosine hydroxylase activation in the various catecholamine neuronal groups and adrenal chromaffin cells. His recent work has focused on the influence of the immune system on the regulation of tyrosine hydroxylase. He has provided the first evidence that peripheral inflammation can induce long-term effects on the regulation of tyrosine hydroxylase in the peripheral and central catecholaminergic systems.

Dr Ong has in total 12 publications since 2007, including 6 journal articles from his PhD studies. He has been first author on 4 papers and has published in respected scientific journals such as Journal of Neurochemistry, PloS One, Neuroscience and Behavioural Brain Research. Dr Ong has also presented his work at many international and national conferences; from his 20 conference publications he has been first author on 10. Since 2010, Dr Ong has 10 travel grants to attend both international and national conferences.

Qualifications

  • PhD (Medical Biochemistry), University of Newcastle, 26/07/2012
  • Bachelor of Biomedical Sciences (Hons), University of Newcastle, 11/07/2008
  • Bachelor of Biomedical Sciences, University of Newcastle, 01/08/2007

Research

Research keywords

  • Parkinson's disease
  • catecholamines
  • protein phosphorylation
  • signal transduction
  • stress animal models
  • tyrosine hydroxylase

Research expertise

My major focus has been the investigation of tyrosine hydroxylase (TH, the rate limiting enzyme of catecholamine biosynthesis) regulation. I have provided the first comprehensive analysis linking TH phosphorylation and TH activation in both cell bodies and nerve terminals in the various catecholamine neuronal groups and adrenal chromaffin cells. I have established that different catecholaminergic cells response differently in term of the temporal profile of TH phosphorylation in a range of animal models of stress. I have also established that TH activation by a range of stressors is transient and only lasts for hours.

My more recent work has focused on the influence of the immune system on TH regulation. I have established that postnatal endotoxin challenge was able to induce sustained TH activation which was maintained into adolescence and adulthood without further interventions. Recently, I have initiated a new research focus on the pathogenic mechanisms in an inflammatory animal model of Parkinson's disease.

My broad technical skills and expertise include neurochemistry, biochemical analyses, immunohistochemistry and behavioural tests on animal models of stress and Parkinson’s disease.

Languages

  • English
  • Malay

Fields of Research

CodeDescriptionPercentage
110100Medical Biochemistry And Metabolomics50
110900Neurosciences50

Memberships

Committee/Associations (relevant to research).

  • Member - The International Society for Neurochemistry
  • Member - The Asian Pacific Society for Neurochemistry
  • Member - Australasian Neuroscience Society
  • Member - International Brain Research Organization
  • Member - Australian Society for Medical Research

Collaboration

Associate Professor Deborah Hodgson, University of Newcastle

  • the role of postnatal immune challenge in neurodevelopment

A/Prof Rodrigo Leal, Universidade Federal de Santa Catarina

  • the role of systemic manganese exposure in parkinsonism

Teaching

Teaching keywords

  • Human Anatomy and Physiology
  • Medical Biochemistry
  • Neuroscience

Teaching expertise

Musculoskeletal Anatomy

Human Bioscience

Human Molecular Science

Human Biochemistry and Cell Biology

Neuroscience

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Highlighted Publications

For publications that are currently unpublished or in-press, details are shown in italics.

YearCitationAltmetricsLink
2014Ong LK, Guan L, Damanhuri H, Goodchild AK, Bobrovskaya L, Dickson PW, Dunkley PR, 'Neurobiological consequences of acute footshock stress: effects on tyrosine hydroxylase phosphorylation and activation in the rat brain and adrenal medulla', JOURNAL OF NEUROCHEMISTRY, 128 547-560 (2014)
2012Ong LK, Sominsky L, Dickson PW, Hodgson DM, Dunkley PR, 'The sustained phase of Tyrosine hydroxylase activation in vivo', Neurochemical Research, 37 1938-1943 (2012) [C1]
2011Ong LK, Guan L, Stutz B, Dickson PW, Dunkley PR, Bobrovskaya L, 'The effects of footshock and immobilization stress on tyrosine hydroxylase phosphorylation in the rat locus coeruleus and adrenal gland', Neuroscience, 192 20-27 (2011) [C1]
2011Ong LK, Bobrovskaya L, Walker FR, Day TA, Dickson PW, Dunkley PR, 'The effect of social defeat on tyrosine hydroxylase phosphorylation in the rat brain and adrenal gland', Neurochemical Research, 36 27-33 (2011) [C1]

Publications

For publications that are currently unpublished or in-press, details are shown in italics.

Click on a category title below to expand the list of citations for that specific category.

Journal article (12 outputs)

YearCitationAltmetricsLink
2014James MH, Quinn RK, Ong LK, Levi EM, Charnley JL, Smith DW, et al., 'mTORC1 inhibition in the nucleus accumbens 'protects' against the expression of drug seeking and 'relapse' and is associated with reductions in GluA1 AMPAR and CAMKIIa levels.', Neuropsychopharmacology, 39 1694-1702 (2014) [C1]
2014Ong LK, Guan L, Damanhuri H, Goodchild AK, Bobrovskaya L, Dickson PW, Dunkley PR, 'Neurobiological consequences of acute footshock stress: effects on tyrosine hydroxylase phosphorylation and activation in the rat brain and adrenal medulla', JOURNAL OF NEUROCHEMISTRY, 128 547-560 (2014)
2013Sominsky L, Fuller EA, Bondarenko E, Ong LK, Averell L, Nalivaiko E, et al., 'Functional Programming of the Autonomic Nervous System by Early Life Immune Exposure: Implications for Anxiety', PLOS ONE, 8 (2013) [C1]
2013Bobrovskaya L, Maniam J, Ong LK, Dunkley PR, Morris MJ, 'Early Life Stress and Post-Weaning High Fat Diet Alter Tyrosine Hydroxylase Regulation and AT1 Receptor Expression in the Adrenal Gland in a Sex Dependent Manner', NEUROCHEMICAL RESEARCH, 38 826-833 (2013) [C1]
2012Ong LK, Sominsky L, Dickson PW, Hodgson DM, Dunkley PR, 'The sustained phase of Tyrosine hydroxylase activation in vivo', Neurochemical Research, 37 1938-1943 (2012) [C1]
2012Sominsky Bar L, Walker AK, Ong LK, Tynan R, Walker FR, Hodgson DM, 'Increased microglial activation in the rat brain following neonatal exposure to a bacterial mimetic', Behavioural Brain Research, 226 351-356 (2012) [C1]
2012Damanhuri HA, Burke PGR, Ong LK, Bobrovskaya L, Dickson PW, Dunkley PR, Goodchild AK, 'Tyrosine hydroxylase phosphorylation in catecholaminergic brain regions: A marker of activation following acute hypotension and glucoprivation', Plos One, 7 1-19 (2012) [C1]
2011Ong LK, Bobrovskaya L, Walker FR, Day TA, Dickson PW, Dunkley PR, 'The effect of social defeat on tyrosine hydroxylase phosphorylation in the rat brain and adrenal gland', Neurochemical Research, 36 27-33 (2011) [C1]
2011Wynne OL, Horvat JC, Kim RY, Ong LK, Smith R, Hansbro PM, et al., 'Neonatal respiratory infection and adult re-infection: Effect on glucocorticoid and mineralocorticoid receptors in the hippocampus in BALB/c mice', Brain Behavior and Immunity, 25 1214-1222 (2011) [C1]
2011Ong LK, Guan L, Stutz B, Dickson PW, Dunkley PR, Bobrovskaya L, 'The effects of footshock and immobilization stress on tyrosine hydroxylase phosphorylation in the rat locus coeruleus and adrenal gland', Neuroscience, 192 20-27 (2011) [C1]
2010Bobrovskaya L, Damanhuri HA, Ong LK, Schneider JJ, Dickson PW, Dunkley PR, Goodchild AK, 'Signal transduction pathways and tyrosine hydroxylase regulation in the adrenal medulla following glucoprivation: An in vivo analysis', Neurochemistry International, 57 162-167 (2010) [C1]
2007O'Leary MA, Schneider JJ, Krishnan BP, Lavis C, McKendry A, Ong LK, Isbister GK, 'Cross-neutralisation of Australian brown and tiger snake venoms with commercial antivenoms: Cross-reactivity or antivenom mixtures?', Toxicon, 50 206-213 (2007) [C1]
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Conference (12 outputs)

YearCitationAltmetricsLink
2012Sominsky Bar L, Fuller AE, Bondarenko E, Ong LK, Clark VR, Bobrovskaya L, et al., 'Neonatal programming of the autonomic nervous system by immunological challenge: Implications for anxiety', Abstracts of the 21st Annual Meeting of the International Behavioral Neuroscience Society, Kona, Hawaii (2012) [E3]
2012Sominsky Bar L, Fuller EA, Bondarenko E, Ong LK, Clark VR, Bobrovskaya L, et al., 'Neonatal immune challenge induces anxiety in adulthood and is associated with functional alterations to the autonomic nervous system', Brain, Behavior, and Immunity, San Diego, CA (2012) [E3]
2012Ong LK, Guan L, Bobrovskaya L, Dickson PW, Dunkley PR, 'Neurobiological consequences of acute footshock stress', Journal of Neurochemistry, Kobe, Japan (2012) [E3]
2011Sominsky Bar L, Walker AK, Ong LK, Tynan R, Walker FR, Hodgson DM, 'Epigenetic inheritance of anxiety-like behaviour in rats - Role of early life exposure to a bacterial mimetic', Journal of Developmental Origins of Health and Disease, Portland, Oregon (2011) [E3]
2011Wynnea O, Horvat JC, Kim RY, Ong LK, Smith R, Hansbro PM, et al., 'Sex differences in the effect of neonatal infection and adult re-infection on hippocampal corticosterone receptors and stress response outcomes', Brain, Behavior, and Immunity, Chicago, Illinois (2011) [E3]
2011Sominsky Bar L, Walker AK, Ong LK, Walker FR, Hodgson DM, 'Postnatal exposure to a bacterial mimetic increases microglial activation and histone H3 acetylation in rats', Brain, Behavior, and Immunity, Chicago, Illinois (2011) [E3]
2010Ong LK, Guan L, Stutz B, Dickson PW, Dunkley PR, Bobrovskaya L, 'Tyrosine hydroxylase phosphorylation in response to footshock and restraint stress', Journal of Neurochemistry, Phuket, Thailand (2010) [E3]
2009Ong LK, Maniam J, Dunkley PR, Bobrovskaya L, Morris MJ, 'The effect of voluntary exercise and high fat diet on tyrosine hydroxylase phosphorylation in male Sprague-Dawley rats exposed to early life stress', Autonomic Neuroscience: Basic and Clinical, Sydney, NSW (2009) [E3]
2009Bobrovskaya L, Ong LK, Walker RA, Day TA, Dickson PW, Dunkley PR, 'The effect of social stress on tyrosine hydroxylase phosphorylation', ANS 2009 Abstracts: Posters, Canberra, ACT (2009) [E3]
2009Damanhuri H, Ong LK, Bobrovskaya L, Dunkley PR, Goodchild AK, 'Activation of tyrosine hydroxylase in the A8, A9 and A10 cell groups following hypotension and glucoprivation in Sprague Dawley rat', Autonomic Neuroscience: Basic and Clinical, Sydney, NSW (2009) [E3]
2009Bobrovskaya L, Damanhuri H, Ong LK, Dickson PW, Dunkley PR, Goodchild AK, 'The effect of glucoprivation on tyrosine hydroxylase phosphorylation in adrenals of Sprague-Dawley rats', Autonomic Neuroscience: Basic and Clinical, Sydney, NSW (2009) [E3]
2009Ong LK, Bobrovskaya L, Walker FR, Day TA, Dickson PW, Dunkley PR, 'The effect of social conflict on tyrosine hydroxylase phosphorylation in catecholamine-producing cells from sprague-dawley rats', Journal of Neurochemistry, Busan, Korea (2009) [E3]
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Grants and Funding

Summary

Number of grants1
Total funding$24,596

- Indicates that the researcher may be seeking students for this project.

Click on a grant title below to expand the full details for that specific grant.

2013 (1 grants)

Ultra-Low Temperature Cryogenic Freezer$24,596
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Doctor Jude Weidenhofer, Doctor Rick Thorne, Doctor Kathryn Skelding, Doctor Nikki Verrills, Doctor Pradeep Tanwar, Associate Professor Phillip Dickson, Conjoint Associate Professor Murray Cairns, Professor Hubert Hondermarck, Professor Xu Dong Zhang, Associate Professor Estelle Sontag, Doctor Chen Chen Jiang, Associate Professor Liz Milward, Doctor Jean-Marie Sontag, Associate Professor Paul Tooney, Doctor Severine Roselli, Doctor Matt Dun, Doctor Chris Dayas, Doctor Lin Kooi Ong, Professor Dirk Van Helden, Mr Ben Copeland, Doctor Gabrielle Briggs, Emeritus Professor Leonie Ashman, Emeritus Professor John Rostas
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$24,59620132013
GNo:G1201189
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Research Supervision

Number of current supervisions0

No Supervisions.

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Dr Lin Kooi Ong

Work Phone(02) 49215736
Email
PositionResearch Associate
Tyrosine Hydroxylase Laboratory
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine
The University of Newcastle, Australia
Office
LS339,
Life Sciences Building ,
Callaghan
University Drive
Callaghan NSW 2308
Australia
URL:www.newcastle.edu.au/profile/linkooi-ong