Dr Lin Kooi Ong

Research Officer

School of Biomedical Sciences and Pharmacy

Career Summary

Biography

Dr Lin Kooi Ong completed Bachelor of Biomedical Science (Honours) in 2008 and obtained a PhD in medical biochemistry from the University of Newcastle in 2012. Dr Ong is a Postdoctoral Researcher at the University of Newcastle and the HMRI Brain and Mental Health Program, investigating the role of infection in the development of Parkinson’s disease.

Dr Ong’s research focus has been on the investigation of the regulation of tyrosine hydroxylase in vivo. In this he has provided the first comprehensive analysis linking tyrosine hydroxylase phosphorylation and tyrosine hydroxylase activation in the various catecholamine neuronal groups and adrenal chromaffin cells. His recent work has focused on the influence of the immune system on the regulation of tyrosine hydroxylase. He has provided the first evidence that peripheral inflammation can induce long-term effects on the regulation of tyrosine hydroxylase in the peripheral and central catecholaminergic systems. In 2013 Dr Ong initiated a new research focus in A/Prof Phillip Dickson’s laboratory (Parkinson/Tyrosine hydroxylase laboratory) on the investigation of the role of inflammation and dopamine synthesis in the specific subset of dopaminergic neurons that are susceptible to degeneration in Parkinson’s disease. This work is currently funded by an HMRI Project Grant and a Faculty of Health and Medicine Pilot Grant.

Dr Ong has in total 12 publications since 2007, including 6 journal articles from his PhD studies. He has been first author on 4 papers and has published in respected scientific journals such as Journal of Neurochemistry, PloS One, Neuroscience and Behavioural Brain Research. Dr Ong has also presented his work at many international and national conferences; from his 20 conference publications he has been first author on 10. Since 2010, Dr Ong has 9 travel grants to attend both international and national conferences.

Research Expertise
My major focus has been the investigation of tyrosine hydroxylase (TH, the rate limiting enzyme of catecholamine biosynthesis) regulation. I have provided the first comprehensive analysis linking TH phosphorylation and TH activation in both cell bodies and nerve terminals in the various catecholamine neuronal groups and adrenal chromaffin cells. I have established that different catecholaminergic cells response differently in term of the temporal profile of TH phosphorylation in a range of animal models of stress. I have also established that TH activation by a range of stressors is transient and only lasts for hours. My more recent work has focused on the influence of the immune system on TH regulation. I have established that postnatal endotoxin challenge was able to induce sustained TH activation which was maintained into adolescence and adulthood without further interventions. Recently, I have initiated a new research focus on the pathogenic mechanisms in an inflammatory animal model of Parkinson's disease. My broad technical skills and expertise include neurochemistry, biochemical analyses, immunohistochemistry and behavioural tests on animal models of stress and Parkinson’s disease.

Teaching Expertise
Musculoskeletal Anatomy Human Bioscience Human Molecular Science Human Biochemistry and Cell Biology Neuroscience. 

Collaborations
Professor Deborah Hodgson, University of Newcastle - the role of postnatal immune challenge in neurodevelopment Professor Rodrigo Leal, Universidade Federal de Santa Catarina - the role of systemic manganese exposure in parkinsonism Professor Daniel Gelain, Federal University of Rio Grande do Sul Brazil -the expression of human tyrosine hydroxylase isoforms in the differentiation of neuroblastoma cells.


Qualifications

  • PhD (Medical Biochemistry), University of Newcastle
  • Bachelor of Biomedical Sciences, University of Newcastle
  • Bachelor of Biomedical Sciences (Hons), University of Newcastle

Keywords

  • Human Anatomy and Physiology
  • Medical Biochemistry
  • Neuroscience
  • Parkinson's disease
  • catecholamines
  • neurochemistry
  • protein phosphorylation
  • signal transduction
  • stress biology
  • tyrosine hydroxylase

Languages

  • Malay (Fluent)

Fields of Research

CodeDescriptionPercentage
110999Neurosciences not elsewhere classified50
110199Medical Biochemistry and Metabolomics not elsewhere classified50

Professional Experience

UON Appointment

DatesTitleOrganisation / Department
26/07/2014 - 31/12/2014Research AssociateUniversity of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
17/03/2014 - 9/05/2014Casual LecturerUniversity of Newcastle
School of Biomedical Sciences and Pharmacy
Australia

Academic appointment

DatesTitleOrganisation / Department
1/01/2014 - Membership - Australian Society for Medical ResearchAustralian Society for Medical Research (ASMR)
Australia
1/03/2012 - Research AssociateUniversity of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
1/01/2012 - Membership - International Brain Research OrganizationInternational Brain Research Organization
Australia
1/01/2010 - Membership - Australasian Neuroscience SocietyAustralasian Neuroscience Society
Australia
1/01/2009 - Membership - The International Society for NeurochemistryThe International Society for Neurochemistry
Australia
1/01/2009 - Membership - The Asian Pacific Society for NeurochemistryThe Asian Pacific Society for Neurochemistry
Australia

Awards

Recipient

YearAward
2014International Brain Research Organization International Travel Grant
International Brain Research Organization

Invitations

Participant

YearTitle / Rationale
2014The role of inflammation and dopamine synthesis in Parkinson’s disease
Organisation: The Asia Pacific Society for Neurochemistry Description: The 12th Meeting of The Asia Pacific Society for Neurochemistry, Kaohsiung, Taiwan.

Speaker

YearTitle / Rationale
2014The role of inflammation and dopamine synthesis in Parkinson’s disease
Organisation: Universiti Putra Malaysia Description: Monthly Neuroscience Seminar, Faculty of Medicine & Health Sciences, Universiti Putra Malaysia
2012Tyrosine hydroxylase phosphorylation and activation in vivo
Organisation: University of South Australia Description: School Seminar, School of Pharmacy and Medical Sciences, University of South Australia
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Journal article (12 outputs)

YearCitationAltmetricsLink
2014James MH, Quinn RK, Ong LK, Levi EM, Charnley JL, Smith DW, et al., 'mTORC1 inhibition in the nucleus accumbens 'protects' against the expression of drug seeking and 'relapse' and is associated with reductions in GluA1 AMPAR and CAMKIIa levels.', Neuropsychopharmacology, 39 1694-1702 (2014) [C1]
DOI10.1038/npp.2014.16Author URL
CitationsScopus - 1
Co-authorsDouglas Smith, Phil Dickson, Christopher Dayas
2014Ong LK, Guan L, Damanhuri H, Goodchild AK, Bobrovskaya L, Dickson PW, Dunkley PR, 'Neurobiological consequences of acute footshock stress: effects on tyrosine hydroxylase phosphorylation and activation in the rat brain and adrenal medulla', JOURNAL OF NEUROCHEMISTRY, 128 547-560 (2014) [C1]
DOI10.1111/jnc.12482Author URL
CitationsScopus - 2Web of Science - 1
Co-authorsPhil Dickson, Peter Dunkley
2013Bobrovskaya L, Maniam J, Ong LK, Dunkley PR, Morris MJ, 'Early Life Stress and Post-Weaning High Fat Diet Alter Tyrosine Hydroxylase Regulation and AT1 Receptor Expression in the Adrenal Gland in a Sex Dependent Manner', NEUROCHEMICAL RESEARCH, 38 826-833 (2013) [C1]
DOI10.1007/s11064-013-0985-4Author URL
CitationsScopus - 1Web of Science - 1
Co-authorsPeter Dunkley
2013Sominsky L, Fuller EA, Bondarenko E, Ong LK, Averell L, Nalivaiko E, et al., 'Functional Programming of the Autonomic Nervous System by Early Life Immune Exposure: Implications for Anxiety', PLOS ONE, 8 (2013) [C1]
DOI10.1371/journal.pone.0057700Author URL
CitationsScopus - 9Web of Science - 10
Co-authorsEugene Nalivaiko, Peter Dunkley, Deborah Hodgson, Phil Dickson
2012Sominsky Bar L, Walker AK, Ong LK, Tynan R, Walker FR, Hodgson DM, 'Increased microglial activation in the rat brain following neonatal exposure to a bacterial mimetic', Behavioural Brain Research, 226 351-356 (2012) [C1]
DOI10.1016/j.bbr.2011.08.038
CitationsScopus - 20Web of Science - 18
Co-authorsDeborah Hodgson, Rohan Walker
2012Ong LK, Sominsky L, Dickson PW, Hodgson DM, Dunkley PR, 'The sustained phase of Tyrosine hydroxylase activation in vivo', Neurochemical Research, 37 1938-1943 (2012) [C1]
CitationsScopus - 6Web of Science - 5
Co-authorsDeborah Hodgson, Peter Dunkley, Phil Dickson
2012Damanhuri HA, Burke PGR, Ong LK, Bobrovskaya L, Dickson PW, Dunkley PR, Goodchild AK, 'Tyrosine hydroxylase phosphorylation in catecholaminergic brain regions: A marker of activation following acute hypotension and glucoprivation', Plos One, 7 1-19 (2012) [C1]
CitationsScopus - 10Web of Science - 7
Co-authorsPeter Dunkley, Phil Dickson
2011Ong LK, Guan L, Stutz B, Dickson PW, Dunkley PR, Bobrovskaya L, 'The effects of footshock and immobilization stress on tyrosine hydroxylase phosphorylation in the rat locus coeruleus and adrenal gland', Neuroscience, 192 20-27 (2011) [C1]
DOI10.1016/j.neuroscience.2011.06.087
CitationsScopus - 7Web of Science - 7
Co-authorsPhil Dickson, Peter Dunkley
2011Ong LK, Bobrovskaya L, Walker FR, Day TA, Dickson PW, Dunkley PR, 'The effect of social defeat on tyrosine hydroxylase phosphorylation in the rat brain and adrenal gland', Neurochemical Research, 36 27-33 (2011) [C1]
DOI10.1007/s11064-010-0255-7
CitationsScopus - 7Web of Science - 7
Co-authorsPhil Dickson, Peter Dunkley, Trevor Day, Rohan Walker
2011Wynne OL, Horvat JC, Kim RY, Ong LK, Smith R, Hansbro PM, et al., 'Neonatal respiratory infection and adult re-infection: Effect on glucocorticoid and mineralocorticoid receptors in the hippocampus in BALB/c mice', Brain Behavior and Immunity, 25 1214-1222 (2011) [C1]
DOI10.1016/j.bbi.2011.03.014
CitationsScopus - 3Web of Science - 3
Co-authorsJay Horvat, Olivia Wynne, Deborah Hodgson, Philip Hansbro, Roger Smith, Vicki Clifton
2010Bobrovskaya L, Damanhuri HA, Ong LK, Schneider JJ, Dickson PW, Dunkley PR, Goodchild AK, 'Signal transduction pathways and tyrosine hydroxylase regulation in the adrenal medulla following glucoprivation: An in vivo analysis', Neurochemistry International, 57 162-167 (2010) [C1]
DOI10.1016/j.neuint.2010.05.009
CitationsScopus - 11Web of Science - 11
Co-authorsJennifer Schneider, Peter Dunkley, Phil Dickson
2007O'Leary MA, Schneider JJ, Krishnan BP, Lavis C, McKendry A, Ong LK, Isbister GK, 'Cross-neutralisation of Australian brown and tiger snake venoms with commercial antivenoms: Cross-reactivity or antivenom mixtures?', Toxicon, 50 206-213 (2007) [C1]
DOI10.1016/j.toxicon.2007.03.014
CitationsScopus - 13Web of Science - 10
Co-authorsGeoff Isbister, Jennifer Schneider
Show 9 more journal articles

Conference (13 outputs)

YearCitationAltmetricsLink
2014Ong LK, Briggs GD, Dunkley PR, Dickson PW, 'The role of inflammation and dopamine synthesis in Parkinson's disease', JOURNAL OF NEUROCHEMISTRY, Kaohsiung, TAIWAN (2014) [E3]
Author URL
Co-authorsPhil Dickson, Peter Dunkley
2012Sominsky Bar L, Fuller AE, Bondarenko E, Ong LK, Clark VR, Bobrovskaya L, et al., 'Neonatal programming of the autonomic nervous system by immunological challenge: Implications for anxiety', Abstracts of the 21st Annual Meeting of the International Behavioral Neuroscience Society, Kona, Hawaii (2012) [E3]
Co-authorsPeter Dunkley, Deborah Hodgson, Eugene Nalivaiko
2012Ong LK, Guan L, Bobrovskaya L, Dickson PW, Dunkley PR, 'Neurobiological consequences of acute footshock stress', Journal of Neurochemistry, Kobe, Japan (2012) [E3]
Co-authorsPhil Dickson, Peter Dunkley
2012Sominsky Bar L, Fuller EA, Bondarenko E, Ong LK, Clark VR, Bobrovskaya L, et al., 'Neonatal immune challenge induces anxiety in adulthood and is associated with functional alterations to the autonomic nervous system', Brain, Behavior, and Immunity, San Diego, CA (2012) [E3]
Co-authorsDeborah Hodgson, Peter Dunkley, Eugene Nalivaiko
2011Sominsky Bar L, Walker AK, Ong LK, Tynan R, Walker FR, Hodgson DM, 'Epigenetic inheritance of anxiety-like behaviour in rats - Role of early life exposure to a bacterial mimetic', Journal of Developmental Origins of Health and Disease, Portland, Oregon (2011) [E3]
Co-authorsDeborah Hodgson, Rohan Walker
2011Wynnea O, Horvat JC, Kim RY, Ong LK, Smith R, Hansbro PM, et al., 'Sex differences in the effect of neonatal infection and adult re-infection on hippocampal corticosterone receptors and stress response outcomes', Brain, Behavior, and Immunity, Chicago, Illinois (2011) [E3]
Co-authorsJay Horvat, Roger Smith, Philip Hansbro, Deborah Hodgson
2011Sominsky Bar L, Walker AK, Ong LK, Walker FR, Hodgson DM, 'Postnatal exposure to a bacterial mimetic increases microglial activation and histone H3 acetylation in rats', Brain, Behavior, and Immunity, Chicago, Illinois (2011) [E3]
DOI10.1016/j.bbi.2011.07.014
Co-authorsDeborah Hodgson
2010Ong LK, Guan L, Stutz B, Dickson PW, Dunkley PR, Bobrovskaya L, 'Tyrosine hydroxylase phosphorylation in response to footshock and restraint stress', Journal of Neurochemistry, Phuket, Thailand (2010) [E3]
DOI10.1093/jac/dkq221
CitationsScopus - 1
Co-authorsPeter Dunkley, Phil Dickson
2009Bobrovskaya L, Damanhuri H, Ong LK, Dickson PW, Dunkley PR, Goodchild AK, 'The effect of glucoprivation on tyrosine hydroxylase phosphorylation in adrenals of Sprague-Dawley rats', Autonomic Neuroscience: Basic and Clinical, Sydney, NSW (2009) [E3]
DOI10.1016/j.autneu.2009.05.191
Co-authorsPhil Dickson, Peter Dunkley
2009Damanhuri H, Ong LK, Bobrovskaya L, Dunkley PR, Goodchild AK, 'Activation of tyrosine hydroxylase in the A8, A9 and A10 cell groups following hypotension and glucoprivation in Sprague Dawley rat', Autonomic Neuroscience: Basic and Clinical, Sydney, NSW (2009) [E3]
DOI10.1016/j.autneu.2009.05.228
Co-authorsPeter Dunkley
2009Ong LK, Maniam J, Dunkley PR, Bobrovskaya L, Morris MJ, 'The effect of voluntary exercise and high fat diet on tyrosine hydroxylase phosphorylation in male Sprague-Dawley rats exposed to early life stress', Autonomic Neuroscience: Basic and Clinical, Sydney, NSW (2009) [E3]
DOI10.1016/j.autneu.2009.05.192
Co-authorsPeter Dunkley
2009Bobrovskaya L, Ong LK, Walker RA, Day TA, Dickson PW, Dunkley PR, 'The effect of social stress on tyrosine hydroxylase phosphorylation', ANS 2009 Abstracts: Posters, Canberra, ACT (2009) [E3]
Co-authorsTrevor Day, Peter Dunkley, Phil Dickson
2009Ong LK, Bobrovskaya L, Walker FR, Day TA, Dickson PW, Dunkley PR, 'The effect of social conflict on tyrosine hydroxylase phosphorylation in catecholamine-producing cells from sprague-dawley rats', Journal of Neurochemistry, Busan, Korea (2009) [E3]
DOI10.1111/j.1471-4159.2009.06242.x
Co-authorsRohan Walker, Phil Dickson, Peter Dunkley, Trevor Day
Show 10 more conferences
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Grants and Funding

Summary

Number of grants1
Total funding$24,596

Click on a grant title below to expand the full details for that specific grant.


20131 grants / $24,596

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News

Translational Brain Repair and Rehabilitation

2 PhD Scholarships - Translational Brain Repair and Rehabilitation

May 15, 2015

2 scholarship opportunities are available for PhD students to research Translational Brain Repair and Rehabilitation under the supervision of Dr Lin Kooi Ong, Associate Professor Rohan Walker and Professor Michael Nilsson.

Dr Lin Kooi Ong

Position

Research Officer
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

Contact Details

Emaillinkooi.ong@newcastle.edu.au
Phone(02) 49215736

Office

RoomHMRI Lvl 3 East Kookaburra Circuit
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