Staff Profile
Career Summary
Biography
Since 2003 I have been researching the normal development and function of both the placenta and how dysregulation of these processes is implicated in a variety of pregnancy pathologies, including preeclampsia. I completed my PhD at the University of Adelaide in 2008 and moved to Newcastle to begin my postdoctoral research with Professor Eugenie Lumbers examining the role of the human intrauterine renin-angiotensin system in normal and abnormal pregnancies.
Qualifications
- PhD, University of Adelaide, 08/05/2008
- Bachelor of Science (Honours), University of Adelaide, 31/12/2003
Research
Research keywords
- endometrium
- placenta
- preeclampsia
- pregnancy
- renin angiotensin system
Research expertise
My research focuses on the interactions between prorenin, the novel prorenin receptor and the renin-angiotensin system (RAS) in intrauterine tissues.
I have shown for the first time that prorenin, the (pro)renin receptor and other RAS components are present in late gestation human amnion, chorion, decidua and placenta and early gestation human placenta. Placental RAS levels at these early stages of gestation are much greater than in term placentae and are highly correlated with vascular endothelial growth factor (VEGF) mRNA levels, suggesting a role for the RAS in placental vasculogenesis.
With Professor Lumbers I have examined the epigenetic and hormonal regulation of prorenin in trophoblasts and decidua, I have examined the expression of circulating prorenin and angiotensin peptides in early pregnancy in women destined to get preeclampsia and gestational hypertension, and have also studied the role of the prorenin/prorenin receptor interaction in the fetal membranes in the initiation of labour.
Languages
- English
Fields of Research
| Code | Description | Percentage |
|---|---|---|
| 110300 | Clinical Sciences | 35 |
| 060699 | Physiology Not Elsewhere Classified | 35 |
| 111400 | Paediatrics And Reproductive Medicine | 30 |
Memberships
Committee/Associations (relevant to research).
- Member - Society for reproductive Biology
Grants and Funding
Summary
| Number of grants | 6 |
|---|---|
| Total funding | $138,477 |
For project grants received where the lead institution is other than the University of Newcastle, details are shown in italics.
Click on a grant title below to expand the full details for that specific grant.
2013 (2 grants)
Identification of a novel urinary biomarker to identify women at risk of developing preeclampsia$23,809
Funding Body: John Hunter Hospital Charitable Trust Fund
| Project Team | ||
|---|---|---|
| Doctor Kirsty Pringle, Doctor Mohamed Galal, Professor Eugenie Lumbers | ||
| Scheme | Role | |
| Research Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $23,809 | 2013 | 2013 |
| GNo:G1300969 | ||
Early Career PULSE Travel Award 2012$6,000
Funding Body: Hunter Medical Research Institute
| Project Team | ||
|---|---|---|
| Doctor Kirsty Pringle | ||
| Scheme | Role | |
| Project Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $6,000 | 2013 | 2013 |
| GNo:G1300202 | ||
2012 (2 grants)
Drugs that act on the renin-angiotensin system; repositioning their therapeutic targets to endometrial cancer$34,454
Funding Body: John Hunter Hospital Charitable Trust Fund
| Project Team | ||
|---|---|---|
| Professor Eugenie Lumbers, Doctor Kirsty Pringle, Dr Henry Murray | ||
| Scheme | Role | |
| Research Grant | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $34,454 | 2012 | 2012 |
| GNo:G1200650 | ||
The role of the intrarenal renin angiotensin system in preeclampsia and gestational hypertension$24,400
Funding Body: Hunter Medical Research Institute
| Project Team | ||
|---|---|---|
| Doctor Kirsty Pringle, Professor Eugenie Lumbers | ||
| Scheme | Role | |
| Project Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $24,400 | 2012 | 2012 |
| GNo:G1101206 | ||
2011 (1 grants)
Role of the renin-angiotensin system in pregnancies complicated by placental insufficiency$25,000
Funding Body: John Hunter Hospital Charitable Trust Fund
| Project Team | ||
|---|---|---|
| Doctor Kirsty Pringle, Professor Eugenie Lumbers, Conjoint Professor Ian Symonds | ||
| Scheme | Role | |
| Research Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $25,000 | 2011 | 2012 |
| GNo:G1100637 | ||
2009 (1 grants)
The role of prorenin in the first trimester placenta: Key to pregnancy success$24,814
Funding Body: Hunter Medical Research Institute
| Project Team | ||
|---|---|---|
| Doctor Kirsty Pringle, Professor Eugenie Lumbers, Conjoint Professor Tam Zakar | ||
| Scheme | Role | |
| Project Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $24,814 | 2009 | 2009 |
| GNo:G0189797 | ||
Research Supervision
| Number of current supervisions | 2 |
|---|---|
| Total current UoN PhD EFTSL | 0.62 |
For supervisions undertaken at an institution other that the University of Newcastle, details are shown in italics, and the institution name is listed below the program name.
Current Supervision
| Commenced | Proposed Completion | Program | Supervisor Type | Research Title |
|---|---|---|---|---|
| 2011 | 2013 | PhD (Human Physiology) | Co-Supervisor | Regulation of the Uteroplacental Renin-Angiotensin System in Human Pregnancy |
| 2009 | 2013 | PhD (Human Physiology) | Co-Supervisor | The Circulating, Intrauterine and Intrarenal Renin Angiotensin Systems in Normal and Pathological Pregnancies |
Dr Kirsty Pringle
| Work Phone | (02) 4042 0372 |
|---|---|
| Fax | (02) 4042 0034 |
| Kirsty.Pringle@newcastle.edu.au | |
| Positions | Research Associate School of Biomedical Sciences and Pharmacy Faculty of Health and Medicine |
| Casual Lecturer School of Biomedical Sciences and Pharmacy Faculty of Health and Medicine | |
| Focus Area | Pharmacy and Experimental Pharmacology |
| Office | Level 3 East W3-095, Hunter Medical Research Institute, Other |
| URL: | www.newcastle.edu.au/profile/kirsty-pringle |
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