Dr Kirsty Pringle

Dr Kirsty Pringle

ARC Future Fellow

School of Biomedical Sciences and Pharmacy (Pharmacy and Experimental Pharmacology)

An inch wide and a mile deep

Dr Kirsty Pringle is acquiring and sharing critical knowledge about pregnancy and women’s reproductive health.

Kirsty Pringle

Putting a creative spin on the old saying ‘You are what you eat,’ Dr Kirsty Pringle is telling soon-to-be mothers ‘You and your baby are what you eat, drink, and come into contact with.’ It’s not as catchy, but with her growing portfolio of evidence-based research on women’s reproductive health, it’ll stick.

“It is quite well known now that the intrauterine environment that the fetus grows in can program that fetus for lifelong health and disease,” Kirsty asserts.

“So the types of foods the mum is consuming during pregnancy and the pollutants she’s exposed to actually affect the growth of the baby and the health of the offspring right into adulthood.”

“At the Mothers and Babies Research Centre, we are interested in getting this first part right so that we can improve the health of the next generation of Australians.”

Beginning her research career in 2003 with a PhD in obstetrics and gynaecology at the University of Adelaide, Kirsty has gone from strength to strength, studying the development of the placenta in mice to improve embryo culture and IVF success rates and then graduating to human studies.

Nipping it in the bud

Currently, Kirsty is collaborating with Dr Kym Rae, Laureate Professor Roger Smith and Emeritus Professor Eugenie Lumbers on observational research of Indigenous maternal, neonatal and infant health. A continuation of her early laboratory work on the development of placentas, the ambitious regional NSW project is seeking to cement a scientific, nuanced understanding of the “multifactorial” pregnancy complications experienced by this at-risk population.

“While other researchers are examining the impact of things like nutrition, anxiety and depression, I am specifically focusing on the programming of kidney disease and cardiovascular disease,” she elaborates.

“There are high rates of both of these illnesses in the Aboriginal community.”

Tracking the progress of more than 200 Indigenous mothers and their newborns recruited from Tamworth, Walgett and Newcastle for five years, the team is searching for ways to narrow, if not close the gap, on Indigenous disadvantage in reproductive health.

“Our goal is to identify what can be changed or improved during pregnancy to support the proper development of the babies’ kidneys so they’re less likely to contract kidney disease when they’re older,” Kirsty explains.

“We’re also hoping to figure out how we can treat preeclampsia earlier and, if possible, more successfully.”

“Those in the cohort who experience it during pregnancy are more likely to develop cardiovascular disease later in life.”

“This research isn’t just about offspring – we want to help the mums too.”

As hardworking as she is forward thinking, Kirsty is planning to translate the team’s findings into something practicable, measurable and valuable.

“Underlying kidney dysfunction is not picked up clinically,” she concedes.

“So I would like to put in place some sort of procedure that allows us to routinely follow up these women and ensure the problem doesn’t grow too big or overwhelming.”

“Really, it should be worked on before it even becomes a problem.”

A drug by any other name

A master at multitasking, Kirsty is simultaneously devoting her attention to endometrial cancer.

“In collaboration with Emeritus Professor Eugenie Lumbers and other Newcastle researchers, we are looking at the medications that are typically used to treat high blood pressure (hypertension) in the general population and seeing if any of them are able to be repositioned to treat endometrial cancer,” she shares.

“Because these drugs are used clinically, they’re already recognised as safe and effective.”

“There is good evidence in the literature to suggest that those taking one class of anti-hypertensive drugs, that is, those drugs that block the renin-angiotensin system, have a reduced risk of certain cancers, in particular, female specific cancers.”

Obtaining different endometrial cancer cell lines from biopsies and other donated patient samples over the past couple of years, Kirsty is working to prove that these medications are also effective in inhibiting the growth of tumours.

“Preliminary data says they are,” she discloses.

Again linking this back to her core laboratory research, Kirsty acknowledges that the renin-angiotensin system, which is involved in the control of blood pressure and in tissue growth and blood vessel development, is also important for placental development.

“In the instance of cancer, we think that the system is overactive while in the placenta, in particular in pregnancies complicated by placental insufficiency, it may be underactive,” she describes.

“The placenta is a brand new, fully functional organ that develops within just a few months to support the baby.”

“This rapid development is essential to nourish the growing baby.”

“In some pregnancies, however, we think that the system is not very active, so you get poor placental growth and that’s why you might get preeclampsia, for example.”

“We want to figure out ways to boost the system so that there is more exchange of nutrients between the mother and the fetus.”

A different kind of gender debate

Kirsty is continuing to build on her postdoctoral research at UON as well, coming across a handful of “fascinating” findings and raising a bigger handful of questions that deserve further probing.

“We’ve long known that male babies are more likely to be born preterm and are at an increased risk of neonatal mortality,” she states.

“I am testing the novel idea that this is related, at least partially, to the fact that the renin angiotensin system is more active in the intrauterine tissues of women who have female babies.”

“I want to understand why this is and why we have this sex difference.”

More about Kirsty's Career

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An inch wide and a mile deep

Dr Kirsty Pringle is acquiring and sharing critical knowledge about pregnancy and women’s reproductive health.

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Career Summary

Biography

Dr Kirsty Pringle is a Research Fellow in the Mothers and Babies Research Centre at the Hunter Medical Research Institute and is part of the Priority Research Centre for Reproductive Sciences.

Dr Pringle’s current research examines the role of the intrauterine, circulating and intrarenal renin angiotensin systems (RASs) in pregnancy. With Professor Eugenie Lumbers she has helped to set up and now successfully manages a research team at the University of Newcastle. Her recent publications, NHMRC grant success (as CIA) and invitations to present at international meetings in highly specialised areas attests to her dedication to the field and highlights her research output. Dr Pringle is now successfully coordinating a productive research team, supervising postgraduate students and working and collaborating independently.

Dr Pringle has a BSc (Hons) and PhD in Obstetrics and Gynaecology from the University of Adelaide (2008). During her postgraduate studies Dr Pringle research focused on the molecular regulators of placentation.

Current research areas of interest include:

  1. The use of markers of the circulating and intrarenal RAS to identify Indigenous women with underlying kidney disease and who are potentially at risk of preeclampsia or SGA (Kirsty is CIA on an NHMRC project grant with Lumbers, Rae, Broughton-Pipkin & Smith).
  2. MicroRNAs that regulate the placental renin angiotensin system and how these impact placental angiogenesis and pregnancy outcome;
  3. Components of the circulating renin angiotensin system as novel early biomarkers of adverse pregnancy outcomes such as preeclampsia and gestational hypertension;
  4. Novel actions of Angiotensin II in the circulation of the preterm neonate and implications for clinical management of preterm cardiovascular compromise; and
  5. The role of the endometrial RAS in endometrial cancer and endometriosis and the potential that RAS blocking drugs could be used to treat these diseases.

Recent Awards/Prizes: Kirsty was awarded a HMRI PULSE Early Career Travel Award in 2012 allowing her to present her findings on the intrarenal RAS at the IX International Vasoactive peptides meeting (Belo Horizonte, Brazil) and the annual congress of The International Society for the Study of Hypertension in Pregnancy (Tromso, Norway). Kirsty was also awarded the Society for Reproductive Biology ECR Collaborative Travel Award in 2013 ($1500) with collaborator Dr Jonathan McGuane (University of Adelaide). This allowed Kirsty to gain hands-on experience with a mouse model of endometriosis and learn new techniques in primary endometrial cell isolation and cell culture. Kirsty is now setting up these techniques in Newcastle.

Peer Reviewed Publications: Since 2011 Kirsty has published 9 research articles, 3 reviews and 1 book chapter. All of these are in highly ranked and/or highly specialised journals and are well cited in her field. In the last 5 years Kirsty has also co-authored 13 abstracts presented at international conferences (5 where she was the presenting author) and 30 abstracts presented at national conferences (11 where she was the presenting author).

National and International Invited Presentations:

Invited Presentations at conferences/meetings:

  • “The placental renin angiotensin system: implications for pregnancies complicated by placental insufficiency” Australian and New Zealand Placenta Research Associations Annual Symposium. Sydney 2013
  • Hunter Medical Research Institute PULSE Business Breakfast. March 2013.
  •  “Epigenetic regulation of the intrauterine RAS”. RAS Club. September 2010.

Invited International Seminars: Loma Linda, California 2012; Collège de France, Paris, France, 2009; Division of Vascular Pharmacology and Metabolism, Erasmus MC, Rotterdam, 2009
Invited National Seminars: Robinson Institute, University of Adelaide, November 2013.

Teaching Expertise
Dr Pringle has supervised 2 PhD students and 3 Honours student to completion. Currently Kirsty is supervising 3 RHD candidates. Although Dr Pringle is a full-time research-only academic, she also gives guest lectures in Placentation and the Developmental Origins of Adult Disease Hypothesis to second year BBiomed Science students.

Administrative Expertise
Dr Pringle is currently the Secretary for the Society for Reproductive Biology and Chair of the Gordon Research Symposium on Angiotensins to be held in Italy, 2016. Dr Pringle has also been on the organising committee for several conferences and symposium days. Her expertise in the fields of Reproductive Biology and Physiology has led to her numerous invitations to peer review grant applications both nationally (including NHMRC) and internationally. Dr Pringle currently reviews up to 12 articles per year for leading international journals in her field including: Human Reproduction Update; PLOS One, Placenta, Hypertension, Clinical Medicine and Research, & Molecular and Cellular Endocrinology.


Qualifications

  • PhD, University of Adelaide
  • Bachelor of Science (Honours), University of Adelaide

Keywords

  • Biochemistry
  • Indigenous health
  • Physiology
  • Reproductive Biology
  • endometrium
  • placenta
  • preeclampsia
  • pregnancy
  • renin angiotensin system

Fields of Research

Code Description Percentage
110399 Clinical Sciences not elsewhere classified 35
111499 Paediatrics and Reproductive Medicine not elsewhere classified 30
060699 Physiology not elsewhere classified 35

Professional Experience

UON Appointment

Title Organisation / Department
Research Associate University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia

Academic appointment

Dates Title Organisation / Department
1/08/2013 -  Secretary Society for Reproductive Biology
Australia
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Chapter (1 outputs)

Year Citation Altmetrics Link
2013 Pringle KG, Lumbers ER, 'The placental renin angiotensin system', The Placenta: Development, Function and Diseases, Nova Science, New York 261-288 (2013) [B1]

Journal article (30 outputs)

Year Citation Altmetrics Link
2016 Pringle KG, Delforce SJ, Wang Y, Ashton KA, Proietto A, Otton G, et al., 'Renin-angiotensin system gene polymorphisms and endometrial cancer.', Endocr Connect, 5 128-135 (2016)
DOI 10.1530/EC-15-0112
Co-authors Rodney Scott, Caroline Blackwell
2016 Ashman AM, Collins CE, Weatherall L, Brown LJ, Rollo ME, Clausen D, et al., 'A cohort of Indigenous Australian women and their children through pregnancy and beyond: the Gomeroi gaaynggal study.', J Dev Orig Health Dis, 7 357-368 (2016)
DOI 10.1017/S204017441600009X
Citations Web of Science - 1
Co-authors Megan Rollo, John Attia, Leanne Brown, Roger Smith, Kym Rae, Caroline Blackwell, Clare Collins
2016 Grimson S, Cox AJ, Pringle KG, Burns C, Lumbers ER, Blackwell CC, Scott RJ, 'The prevalence of unique SNPs in the renin-angiotensin system highlights the need for pharmacogenetics in Indigenous Australians', Clinical and Experimental Pharmacology and Physiology, 43 157-160 (2016)

© 2016 John Wiley & Sons Australia, Ltd.Genetic differences between ethnic populations affect susceptibility to disease and efficacy of drugs. This study examined and compared th... [more]

© 2016 John Wiley & Sons Australia, Ltd.Genetic differences between ethnic populations affect susceptibility to disease and efficacy of drugs. This study examined and compared the prevalence of single nucleotide polymorphisms (SNPs) in genes of the renin-angiotensin system (RAS) in a desert community of Indigenous Australians and in non-Indigenous Australians. The polymorphisms were angiotensinogen, AGT G-217A (rs5049); AGT G+174A (rs4762); Angiotensin II type 1 receptor, AGTR1 A+1166C (rs5186); angiotensin converting enzyme, ACE A-240T (rs4291), ACE T-93C (rs4292); renin, REN T+1142C (rs5706). They were measured using allelic discrimination assays. The prevalence of REN T+1142C SNP was similar in the two populations; 99% were homozygous for the T allele. All other SNPs were differently distributed between the two populations (P < 0.0001). In non-Indigenous Australians, the A allele at position 204 of ACE rs4291 was prevalent (61.8%) whereas in the Indigenous Australians the A allele was less prevalent (28%). For rs4292, the C allele had a prevalence of 37.9% in non-Indigenous Australians but in Indigenous Australians the prevalence was only 1%. No Indigenous individuals were homozygous for the C allele of AGTR1 (rs5186). Thus the prevalence of RAS SNPs in this Indigenous Australian desert community was different from non-Indigenous Australians as was the prevalence of cytokine SNPs (as shown in a previous study). These differences may affect susceptibility to chronic renal and cardiovascular disease and may alter the efficacy of drugs used to inhibit the RAS. These studies highlight the need to study the pharmacogenetics of drug absorption, distribution, metabolism and excretion in Indigenous Australians for safe prescribing guidelines.

DOI 10.1111/1440-1681.12525
Co-authors Caroline Blackwell, Rodney Scott
2016 Delforce SJ, Wang Y, Van-Aalst ME, Corbisier De Meaultsart C, Morris BJ, Broughton-Pipkin F, et al., 'Effect of oxygen on the expression of renin-angiotensin system components in a human trophoblast cell line', Placenta, 37 1-6 (2016)

© 2015 Elsevier Ltd. All rights reserved.During the first trimester, normal placental development occurs in a low oxygen environment that is known to stimulate angiogenesis via u... [more]

© 2015 Elsevier Ltd. All rights reserved.During the first trimester, normal placental development occurs in a low oxygen environment that is known to stimulate angiogenesis via upregulation of vascular endothelial growth factor (VEGF). Expression of the placental renin-angiotensin system (RAS) is highest in early pregnancy. While the RAS and oxygen both stimulate angiogenesis, how they interact within the placenta is unknown. We postulated that low oxygen increases expression of the proangiogenic RAS pathway and that this is associated with increased VEGF in a first trimester human trophoblast cell line (HTR-8/SVneo). HTR-8/SVneo cells were cultured in one of three oxygen tensions (1%, 5% and 20%). RAS and VEGF mRNA expression were determined by qPCR. Prorenin, angiotensin converting enzyme (ACE) and VEGF protein levels in the supernatant, as well as prorenin and ACE in cell lysates, were measured using ELISAs. Low oxygen significantly increased the expression of both angiotensin II type 1 receptor (AGTR1) and VEGF (both P < 0.05). There was a positive correlation between AGTR1 and VEGF expression at low oxygen (r = 0.64, P < 0.005). Corresponding increases in VEGF protein were observed with low oxygen (P < 0.05). Despite no change in ACE1 mRNA expression, ACE levels in the supernatant increased with low oxygen (1% and 5%, P < 0.05). Expression of other RAS components did not change. Low oxygen increased AGTR1 and VEGF expression, as well as ACE and VEGF protein levels, suggesting that the proangiogenic RAS pathway is activated. This highlights a potential role for the placental RAS in mediating the proangiogenic effects of low oxygen in placental development.

DOI 10.1016/j.placenta.2015.11.011
2015 Wang Y, Lumbers ER, Sykes SD, Pringle KG, 'Regulation of the renin-angiotensin system pathways in the human decidua', Reproductive Sciences, 22 865-872 (2015) [C1]

© 2014 The Author(s).Pregnancy outcome is influenced, in part, by the sex of the fetus. Decidual renin messenger RNA (REN) abundance is greater in women carrying a female fetus t... [more]

© 2014 The Author(s).Pregnancy outcome is influenced, in part, by the sex of the fetus. Decidual renin messenger RNA (REN) abundance is greater in women carrying a female fetus than a male fetus. Here, we explore whether the sex of the fetus also influences the regulation of decidual RAS expression with a known stimulator of renal renin and cyclic adenosine monophosphate (cAMP). Cyclic adenosine monophosphate had no affect on decidual REN expression, since REN abundance was still greater in decidual explants from women carrying a female fetus than a male fetus after cAMP treatment. Cyclic adenosine monophosphate decreased prorenin levels in the supernatant if the fetus was female (ie, prorenin levels were no longer sexually dimorphic) and altered the fetal sex-specific differences in other RAS genes seen in vitro. Therefore, fetal sex influences the decidual renin-angiotensin system response to cAMP. This may be related to the presence of fetal cells in the maternal decidua.

DOI 10.1177/1933719114565029
2015 Pringle KG, Conquest A, Mitchell C, Zakar T, Lumbers ER, 'Effects of Fetal Sex on Expression of the (Pro)renin Receptor and Genes Influenced by its Interaction With Prorenin in Human Amnion', Reproductive Sciences, 22 750-757 (2015) [C1]

© The Author(s) 2014.Males are more likely to be born preterm than females. The causes are unknown, but it is suggested that intrauterine tissues regulate fetal growth and surviv... [more]

© The Author(s) 2014.Males are more likely to be born preterm than females. The causes are unknown, but it is suggested that intrauterine tissues regulate fetal growth and survival in a sex-specific manner. We postulated that prorenin binding to its prorenin/renin receptor receptor (ATP6AP2) would act in a fetal sex-specific manner in human amnion to regulate the expression of promyelocytic zinc finger, a negative regulator of ATP6AP2 expression as well as 2 pathways that might influence the onset of labor, namely transforming growth factor ß1 (TGFB1) and prostaglandin endoperoxide synthase 2 (PTGS2). Our findings demonstrate that there are strong interactions between prorenin, ATP6AP2, and TGFB1 and that this system has a greater capacity in female amnion to stimulate profibrotic pathways, thus maintaining the integrity of the fetal membranes. In contrast, glucocorticoids or other factors independent of the prorenin/prorenin receptor pathway may be important regulators of PTGS2 in human pregnancy.

DOI 10.1177/1933719114561555
2015 Standen P, Sferruzzi-Perri AN, Taylor R, Heinemann G, Zhang JV, Highet AR, et al., 'Maternal insulin-like growth factor 1 and 2 differentially affect the renin-angiotensin system during pregnancy in the guinea pig', GROWTH HORMONE & IGF RESEARCH, 25 141-147 (2015) [C1]
DOI 10.1016/j.ghir.2015.02.001
2015 Pringle KG, Wang Y, Lumbers ER, 'The synthesis, secretion and uptake of prorenin in human amnion.', Physiological reports, 3 (2015) [C1]
2015 Sykes SD, Mitchell C, Pringle KG, Wang Y, Zakar T, Lumbers ER, 'Methylation of promoter regions of genes of the human intrauterine renin angiotensin system and their expression', International Journal of Endocrinology, 2015 (2015) [C1]

© 2015 Shane D. Sykes et al.The intrauterine renin angiotensin system (RAS) is implicated in placentation and labour onset. Here we investigate whether promoter methylation of RA... [more]

© 2015 Shane D. Sykes et al.The intrauterine renin angiotensin system (RAS) is implicated in placentation and labour onset. Here we investigate whether promoter methylation of RAS genes changes with gestation or labour and if it affects gene expression. Early gestation amnion and placenta were studied, as were term amnion, decidua, and placenta collected before labour (at elective caesarean section) or after spontaneous labour and delivery. The expression and degree of methylation of the prorenin receptor (ATP6AP2), angiotensin converting enzyme (ACE), angiotensin II type 1 receptor (AGTR1), and two proteases that can activate prorenin (kallikrein, KLK1, and cathepsin D, CTSD) were measured by qPCR and a DNA methylation array. There was no effect of gestation or labour on the methylation of RAS genes and CTSD. Amnion and decidua displayed strong correlations between the percent hypermethylation of RAS genes and CTSD, suggestive of global methylation. There were no correlations between the degree of methylation and mRNA abundance of any genes studied. KLK1 was the most methylated gene and the proportion of hypermethylated KLK1 alleles was lower in placenta than decidua. The presence of intermediate methylated alleles of KLK1 in early gestation placenta and in amnion after labour suggests that KLK1 methylation is uniquely dynamic in these tissues.

DOI 10.1155/2015/459818
2015 Pringle KG, Weatherall L, Corbisier de Meaultsart C, Keogh L, Sands S, Blackwell C, et al., 'The Gomeroi Gaaynggal Cohort: A Preliminary Study of the Maternal Determinants of Pregnancy Outcomes in Indigenous Australian Women', Journal of Pregnancy and Child Health, 3 (2015) [C1]
DOI 10.4172/2376-127X.1000211
Co-authors Sharron Hall, Kym Rae, Roger Smith, Clare Collins, Caroline Blackwell
2015 Pringle KG, Rae K, Weatherall L, Hall S, Burns C, Smith R, et al., 'Effects of maternal inflammation and exposure to cigarette smoke on birth weight and delivery of preterm babies in a cohort of Indigenous Australian women', Frontiers in Immunology, 6 (2015) [C1]

© 2015 Pringle, Rae, Weatherall, Hall, Burns, Smith, Lumbers and Blackwell.Sudden infant death syndrome (SIDS), neonatal deaths, and deaths from infection are higher among Indige... [more]

© 2015 Pringle, Rae, Weatherall, Hall, Burns, Smith, Lumbers and Blackwell.Sudden infant death syndrome (SIDS), neonatal deaths, and deaths from infection are higher among Indigenous Australians. This study aimed to determine the effects of inflammatory responses and exposure to cigarette smoke, two important factors associated with sudden death in infancy, on preterm birth, and birth weight in a cohort of Indigenous mothers. Indigenous Australian women (n = 131) were recruited as part of a longitudinal study while attending antenatal care clinics during pregnancy; blood samples were collected up to three times in pregnancy. Serum cotinine, indicating exposure to cigarette smoke, was detected in 50.4% of mothers. Compared with non-Indigenous women, the cohort had 10 times the prevalence of antibodies to Helicobacter pylori (33 vs. 3%). Levels of immunoglobulin G, antibodies to H. pylori, and C-reactive protein (CRP) were all inversely correlated with gestational age (P < 0.05). CRP levels were positively associated with maternal body mass index (BMI; ¿ = 0.449, P = 0.001). The effects of cigarette smoke (cotinine) and inflammation (CRP) were assessed in relation to risk factors for SIDS: gestational age at delivery and birth weight. Serum cotinine levels were negatively associated with birth weight (¿ = -0.37, P < 0.001), this correlation held true for both male (¿ = -0.39, P = 0.002) and female (¿ = -0.30, P = 0.017) infants. Cotinine was negatively associated with gestational age at delivery (¿ = -0.199, P = 0.023). When assessed by fetal sex, this was significant only for males (¿ = -0.327, P = 0.011). CRP was negatively associated with gestational age at delivery for female infants (¿ = -0.46, P < 0.001). In contrast, maternal BMI was significantly correlated with birth weight. These data highlight the importance of putting programs in place to reduce cigarette smoke exposure in pregnancy and to treat women with chronic infections such as H. pylori to improve pregnancy outcomes and decrease risk factors for sudden death in infancy.

DOI 10.3389/fimmu.2015.00089
Citations Scopus - 1
Co-authors Sharron Hall, Caroline Blackwell, Roger Smith, Kym Rae
2015 Lumbers ER, Wang Y, Delforce SJ, Corbisier de Meaultsart C, Logan PC, Mitchell MD, Pringle KG, 'Decidualisation of human endometrial stromal cells is associated with increased expression and secretion of prorenin', Reproductive Biology and Endocrinology, 13 (2015) [C1]

© 2015 Lumbers et al.Background: In pregnancy, the decidualised endometrium expresses high levels of prorenin and other genes of the renin-angiotensin system (RAS) pathway. In th... [more]

© 2015 Lumbers et al.Background: In pregnancy, the decidualised endometrium expresses high levels of prorenin and other genes of the renin-angiotensin system (RAS) pathway. In this study we aimed to determined if the RAS was present in endometrial stromal cells and if decidualisation upregulated the expression of prorenin, the prorenin receptor ((P)RR) and associated RAS pathways. Immortalised human endometrial stromal cells (HESCs) can be stimulated to decidualise by combined treatment with medroxyprogesterone acetate (MPA), 17ß-estradiol (E2) and cAMP (MPA-mix) or with 5-aza-2'-deoxycytidine (AZA), a global demethylating agent. Methods: HESCs were incubated for 10days with one of the following treatments: vehicle, MPA-mix, a combination of medroxyprogesterone acetate (MPA) and estradiol-17ß alone, or AZA. Messenger RNA abundance and protein levels of prorenin (REN), the (P)RR (ATP6AP2), angiotensinogen (AGT), angiotensin converting enzyme (ACE), angiotensin II type 1 receptor (AGTR1), vascular endothelial growth factor (VEGF), and plasminogen activator inhibitor-1 (PAI-1) were measured by real-time PCR and ELISA's, respectively. Promyelocytic zinc finger (PLZF) and phospho-inositol-3 kinase (PIK3R1) mRNA abundances were also measured. Results: HESCs expressed the prorenin receptor (ATP6AP2), REN, AGT, ACE and low levels of AGTR1. MPA-mix and AZA stimulated expression of REN. Prorenin protein secretion was increased in MPA-mix treated HESCs. E2 + MPA had no effect on any RAS genes. MPA-mix treatment was associated with increased VEGF (VEGFA) and PAI-1 (SERPINE1) mRNA and VEGF protein. Conclusions: An endometrial prorenin receptor/renin angiotensin system is activated by decidualisation. Since (P)RR is abundant, the increase in prorenin secretion could have stimulated VEGF A and SERPINE1 expression via Ang II, as both ACE and AGTR1 are present, or by Ang II independent pathways. Activation of the RAS in human endometrium with decidualisation, through stimulation of VEGF expression and secretion, could be critical in establishing an adequate blood supply to the developing maternal placental vascular bed.

DOI 10.1186/s12958-015-0127-8
Citations Scopus - 1Web of Science - 2
2015 Pringle KG, Sykes SD, Lumbers ER, 'Circulating and intrarenal renin-angiotensin systems in healthy men and nonpregnant women.', Physiol Rep, 3 (2015) [C1]
DOI 10.14814/phy2.12586
2014 Sykes SD, Pringle KG, Zhou A, Dekker GA, Roberts CT, Lumbers ER, SCOPE Consortium, 'The balance between human maternal plasma angiotensin II and angiotensin 1-7 levels in early gestation pregnancy is influenced by fetal sex.', J Renin Angiotensin Aldosterone Syst, 15 523-531 (2014) [C1]
DOI 10.1177/1470320313477174
2014 Lumbers ER, Pringle KG, 'Roles of the circulating renin-angiotensin-aldosterone system in human pregnancy', AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 306 R91-R101 (2014) [C1]
DOI 10.1152/ajpregu.00034.2013
Citations Scopus - 9Web of Science - 11
2014 Sykes SD, Pringle KG, Zhou A, Dekker GA, Roberts CT, Lumbers ER, 'Fetal sex and the circulating renin-angiotensin system during early gestation in women who later develop preeclampsia or gestational hypertension', Journal of Human Hypertension, 28 133-139 (2014) [C1]

There are fetal sex-specific differences in the balance between angiotensin (Ang) II and Ang-(1-7) in the maternal circulation during pregnancy. To determine whether at 15 weeks' ... [more]

There are fetal sex-specific differences in the balance between angiotensin (Ang) II and Ang-(1-7) in the maternal circulation during pregnancy. To determine whether at 15 weeks' gestation plasma levels of Ang II and Ang-(1-7), as well as levels of prorenin and Ang-converting enzyme (ACE), predicted the development of gestational hypertension (GH) or preeclampsia (PreE) and were associated with estimates of fetal and maternal health, women who later developed GH (n=50) or PreE (n=50) were compared with body mass index-matched controls (n=100). Women who subsequently developed PreE or GH had increased Ang-(1-7) levels at 15 weeks' gestation compared with women with normal pregnancies. When separated by fetal sex, this difference was seen only in women carrying a female fetus. Prorenin and ACE concentrations were not useful biomarkers for the prediction of either PreE or GH at 15 weeks' gestation. Women with a male fetus who developed PreE and women who subsequently developed GH had increased blood pressures at 15 weeks' gestation compared with women with normal pregnancies, suggesting that these women were on an early trajectory for the development of hypertension. We propose that measurement of Ang-(1-7) during early gestation could be useful in predicting, those women who will go on to develop new-onset hypertension in pregnancy.

DOI 10.1038/jhh.2013.51
Citations Scopus - 8Web of Science - 6
2014 Rae KM, Weatherall L, Blackwell CC, Pringle K, Smith R, Lumbers E, 'Long conversations: Gomeroi gaaynggal tackles renal disease in the Indigenous community', Australasian Epidemiologist, 21 44-48 (2014) [C2]
Co-authors Roger Smith, Caroline Blackwell, Kym Rae
2013 Wang Y, Pringle KG, Lumbers ER, 'The effects of cyclic AMP, sex steroids and global hypomethylation on the expression of genes controlling the activity of the renin-angiotensin system in placental cell lines', PLACENTA, 34 275-280 (2013) [C1]
DOI 10.1016/j.placenta.2012.12.018
Citations Scopus - 6Web of Science - 5
2013 Mitchell CM, Sykes SD, Pan X, Pringle KG, Lumbers ER, Hirst JJ, Zakar T, 'Inflammatory and steroid receptor gene methylation in the human amnion and decidua', JOURNAL OF MOLECULAR ENDOCRINOLOGY, 50 267-277 (2013) [C1]
DOI 10.1530/JME-12-0211
Citations Scopus - 3Web of Science - 3
Co-authors Jon Hirst
2013 Lumbers ER, Pringle KG, Wang Y, Gibson KJ, 'The renin-angiotensin system from conception to old age: the good, the bad and the ugly', CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 40 743-752 (2013) [C1]
DOI 10.1111/1440-1681.12098
Citations Scopus - 9Web of Science - 4
2012 Wang Y, Pringle KG, Sykes SD, Marques FZ, Morris BJ, Zakar T, Lumbers ER, 'Fetal sex affects expression of renin-angiotensin system components in term human decidua', Endocrinology, 153 462-468 (2012) [C1]
Citations Scopus - 15Web of Science - 11
2012 Wang Y, Pringle KG, Chen Y, Zakar T, Lumbers ER, 'Regulation of the renin-angiotensin system (RAS) in BeWo and HTR-8/SVneo trophoblast cell lines', Placenta, 33 634-639 (2012) [C1]
Citations Scopus - 7Web of Science - 4
2011 Pringle KG, Zakar T, Roach DM, Mitchell CM, Hirst JJ, Lumbers ER, 'Molecular evidence of a (pro)renin/(pro)renin receptor system in human intrauterine tissues in pregnancy and its association with PGHS-2', Journal of the Renin-Angiotensin-Aldosterone System, 12 304-310 (2011) [C1]
DOI 10.1177/1470320310376554
Citations Scopus - 12Web of Science - 10
Co-authors Jon Hirst
2011 Marques FZ, Pringle KG, Conquest AL, Hirst JJ, Markus MA, Sarris M, et al., 'Molecular characterization of renin-angiotensin system components in human intrauterine tissues and fetal membranes from vaginal delivery and cesarean section', Placenta, 32 214-221 (2011) [C1]
DOI 10.1016/j.placenta.2010.12.006
Citations Scopus - 22Web of Science - 19
Co-authors Jon Hirst
2011 Sferruzzi-Perri AN, Owens JA, Pringle KG, Roberts CT, 'The neglected role of insulin-like growth factors in the maternal circulation regulating fetal growth', Journal of Physiology, 589 7-20 (2011) [C1]
DOI 10.1113/jphysiol.2010.198622
Citations Scopus - 32Web of Science - 25
2011 Pringle KG, Tadros MA, Callister RJ, Lumbers ER, 'The expression and localization of the human placental prorenin/renin-angiotensin system throughout pregnancy: Roles in trophoblast invasion and angiogenesis?', Placenta, 32 956-962 (2011) [C1]
Citations Scopus - 34Web of Science - 30
Co-authors Robert Callister
2010 Pringle KG, Kind KL, Sferruzzi-Perri AN, Thompson JG, Roberts CT, 'Beyond oxygen: Complex regulation and activity of hypoxia inducible factors in pregnancy', Human Reproduction Update, 16 415-431 (2010) [C3]
DOI 10.1093/humupd/dmp046
Citations Scopus - 87
2007 Pringle KG, Kind KL, Thompson JG, Roberts CT, 'Complex Interactions Between Hypoxia Inducible Factors, Insulin-Like Growth Factor-II and Oxygen in Early Murine Trophoblasts', Placenta, 28 1147-1157 (2007) [C1]
DOI 10.1016/j.placenta.2007.05.009
2007 Pringle KG, Roberts CT, 'New Light on Early Post-Implantation Pregnancy in the Mouse: Roles for Insulin-Like Growth Factor-II (IGF-II)?', Placenta, 28 286-297 (2007) [C1]
DOI 10.1016/j.placenta.2006.04.006
2006 Pringle KG, 'Maternal Insulin-Like Growth Factors-I and -II Act via Different Pathways to Promote Fetal Growth.', Endocrinology, 147 3344-3355 (2006) [C1]
DOI 10.1210/en.2005-1328
Show 27 more journal articles

Conference (48 outputs)

Year Citation Altmetrics Link
2015 Pringle K, Grimson S, Wang Y, Weatherall L, Smith R, Rae KM, et al., 'Cytokine Gene Polymorphisms in an Indigenous Australian Pregnancy Population', Reproductive Sciences (2015) [E3]
Co-authors Kym Rae, Caroline Blackwell, Roger Smith
2015 Lumbers ER, Grimson S, Cox AJ, Pringle KJ, Burns C, Blackwell CC, Scott RJ, 'THE DISTRIBUTION OF SOME SINGLE NUCLEOTIDE POLYMORPHISMS OF THE RENIN-ANGIOTENSIN SYSTEM IN INDIGENOUS AUSTRALIANS', HYPERTENSION (2015) [E3]
Co-authors Rodney Scott, Caroline Blackwell
2015 Wang Y, Pringle KG, Conquest A, Mitchell C, Zakar T, Lumbers ER, 'A Potential Mechanism By Which Fetal Sex Influences the Prevalence of Preterm Birth', REPRODUCTIVE SCIENCES (2015) [E3]
2015 Rae KM, Weatherall L, Collins C, Smith R, Lumbers ER, Pringle K, 'Maternal obesity negatively impacts on fetal maternal health and birth outcomes in an Indigenous Australian cohort', Journal of Developmental Origins of Health and Disease (2015) [E3]
Co-authors Clare Collins, Kym Rae, Roger Smith
2015 Rae KM, Pringle K, Sykes S, Weatherall L, Clausen D, Smith R, et al., 'Factors affecting blood pressure and renal health in Australian Indigenous Women', Reproductive Sciences (2015) [E3]
Co-authors Caroline Blackwell, Kym Rae, Roger Smith
2015 Pringle K, Sykes S, Weatherall L, Clausen D, Smith R, Rae KM, Lumbers E, 'Interrelationships between circulating and urinary components of the renin-angiotensin system in Indigenous pregnant women', Reproductive Sciences (2015) [E3]
Co-authors Roger Smith, Kym Rae
2015 Smith R, Rae K, Lumbers E, Kandasamy Y, Pringle K, Weatherall L, 'Preterm birth and low birthweight in the Aboriginal and Torres Strait Islander Population', BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY (2015) [E3]
Co-authors Roger Smith, Kym Rae
2015 Pringle KG, 'Why boys are more likely to be born preterm: a novel mechanism for maintaining the fetal membranes in pregnancy', Society of Reproductive Biology/Endocrine Society of Australia Annual Scientific Meeting. Oral Abstracts (2015) [E3]
2015 Pringle KG, Weatherall L, Collins CE, Smith R, Rae K, 'Maternal Obesity negatively impacts on fetal kidney development, maternal health and birth outcomes in an Indigenous Australian cohort', Society of Reproductive Biology/Endocrine Society of Australia Annual Scientific Meeting. Oral Abstracts (2015) [E3]
Co-authors Kym Rae, Clare Collins, Roger Smith
2015 Lumbers ER, Sykes SD, Weatherall L, Clausen D, Smith R, Rae K, Pringle KG, 'INTERRELATIONSHIPS BETWEEN CIRCULATING AND URINARY COMPONENTS OF THE RENIN-ANGIOTENSIN SYSTEM IN INDIGENOUS PREGNANT WOMEN', HYPERTENSION (2015) [O1]
Co-authors Kym Rae, Roger Smith
2014 Wang Y, Morris B, Roberts CT, Broughton-Pipkin F, Lumbers ER, Pringle KG, 'Effect of low oxygen on the pro-angiogenic pathways of the renin angiotensin system (RAS) in a human trophoblast cell line.', Journal of Pediatrics and Child Health (2014) [E3]
DOI 10.1111/jpc.12528
2014 Pringle K, Rae KM, Weatherall L, Hall S, Burns C, Smith R, et al., 'Effects of cigarette smoke and maternal inflammation in pregnancy on birth weight and gestational age at delivery in an Indigenous Australian population', Proceedings of the 57th ESA and 45th SRB Annual Conference (2014) [E3]
Co-authors Kym Rae, Roger Smith, Sharron Hall, Caroline Blackwell
2014 Lumbers ER, Grimson S, Cox A, Pringle KG, Burns C, Blackwell CC, Scott R, 'The distribution of some nucleotide polymorphisms of the renin-angiotensin system in Indigenous Australians.', State of Heart 2014 Congress (2014) [E3]
Co-authors Caroline Blackwell, Rodney Scott
2014 Rae KM, Pringle KG, Sykes SD, Weatherall L, Clausen D, Smith R, et al., 'Factors affecting blood pressure and renal health in young Indigenous pregnant women', State of the Heart 2014 Congress (2014) [E3]
Co-authors Kym Rae, Caroline Blackwell, Roger Smith
2014 Pringle KG, Sykes S, Diehm C, Weatherall L, Galal M, Clausen D, et al., 'The intrarenal renin angiotensin system in pregnancy and its potential in predicting renal dysfunction and fetal kidney development in Indigenous and non-Indigenous Australian women', Abstracts of the 18th Congress of the Perinatal Society of Australia and New Zealand (PSANZ) (2014) [E3]
DOI 10.1111/jpc.12528/abstract
Co-authors Roger Smith, Kym Rae
2014 Lumbers ER, Pringle KG, Sykes SD, Weatherall L, Clausen DC, Rae K, Smith R, 'THE INTRARENAL RENIN-ANGIOTENSIN SYSTEM (RAS) IN HUMAN PREGNANCY', HYPERTENSION (2014) [E3]
Co-authors Roger Smith, Kym Rae
2014 Delforce SJ, Pringle KG, Wang Y, Verrills NM, Scott RJ, Lumbers ER, 'THE FUNCTIONAL ROLE OF THE ENDOMETRIAL RENIN ANGIOTENSIN SYSTEM IN ENDOMETRIAL CANCER', ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY (2014) [E3]
Co-authors Nikki Verrills, Rodney Scott
2013 Pringle KG, Sykes SD, Weatherall L, Clausen D, Smith R, Rae KM, Lumbers ER, 'Novel Urinary Biomarkers for Predicting Pregnancy Outcome in Indigenous and Non- Indigenous Australian Women', Published proceedings of the Fetal and Neonatal Workshop (2013) [E3]
Co-authors Roger Smith, Kym Rae
2013 Pringle K, Sykes SD, Weatherall L, Clausen D, Smith R, Rae KM, Lumbers ER, 'Novel renal biomarkers for predicting pregnancy outcome', Published proceedings of the Symposium on Vasoactive Peptides (2013) [E3]
Co-authors Roger Smith, Kym Rae
2013 Lumbers ER, Wang Y, Pringle KG, Scott RJ, 'Expression of the renin-angiotensin system in an endometrial cancer cell line', Published proceedings of the Symposium on Vasoactive Peptides (2013) [E3]
Co-authors Rodney Scott
2013 Rae KM, Lumbers ER, Pringle KG, Sykes SD, Weatherall L, Clausen D, Smith R, 'Measurement of the activity of the circulating and intrarenal renin-angiotensin system (iRAS) in pregnant and non-pregnant subjects PP036', Pregnancy Hypertension (2013)
Co-authors Roger Smith, Kym Rae
2013 Uddin MN, Horvat D, Roth AL, Pringle KG, Allen SR, Jones RO, et al., 'HYPERGLYCEMIA INDUCES AN ANTI-ANGIOGENIC MILIEU IN FIRST TRIMESTER CYTOTROPHOBLAST CELL', FASEB JOURNAL (2013) [E3]
2013 Uddin MN, Allen SR, Jones RO, Kuehl TJ, Horvat D, Zawieja DC, et al., '(PRO)RENIN AND ITS RECEPTOR DURING PREGNANCY AND PREECLAMSIA: A TRANSLATIONAL APPROACH WITH PATIENTS, A RAT MODEL AND IN VITRO STUDIES', JOURNAL OF INVESTIGATIVE MEDICINE (2013) [E3]
2013 Horvat D, Zawieja DC, Allen SR, Jones RO, Kuehl TJ, Uddin MN, et al., 'SUPPRESSION OF ALDOSTERONE AND PROGESTERONE IN PREECLAMPSIA: PATIENTS AND A RAT MODEL STUDIES', JOURNAL OF INVESTIGATIVE MEDICINE (2013) [E3]
2013 Pringle, Lumbers, Sykes, Weatherall, Clausen D, Rae KM, Smith, 'The intrarenal renin angiotensin system and pregnancy outcome.', Pregnancy Hypertension: an International Journal of Women's Cardiovascular Health (2013) [E3]
DOI 10.1016/j.preghy.2013.04.063
Co-authors Kym Rae, Roger Smith
2013 Lumbers, Pringle, Sykes, Weatherall, Clausen D, Rae KM, Smith, 'Measurement of the activity of the circulating and intrarenal renin-angiotensin system (iRAS) in pregnant and non-pregnant subjects.', Pregnancy Hypertension: an International Journal of Women¿s Cardiovascular Health. (2013) [E3]
DOI 10.1016/j.preghy.2013.04.053
Co-authors Kym Rae, Roger Smith
2012 Sykes SD, Lumbers ER, Pringle KG, Zhou A, Dekker GA, Roberts CT, 'Alterations in the maternal renin angiotensin system (RAS) in women who deliver preterm or small for gestational age babies', Abstracts. The Annual Scientific Meeting of the Endocrine Society of Australia and the Society for Reproductive Biology 2012 (2012) [E3]
2012 Pringle KG, Wang Y, Lumbers ER, 'Evidence for the synthesis, secretion and uptake of prorenin in human amnion', Abstracts. The Annual Scientific Meeting of the Endocrine Society of Australia and the Society for Reproductive Biology 2012 (2012) [E3]
2012 Wang Y, Pringle KG, Lumbers ER, 'Effects of cAMP on sexually determined renin expression and secretion by human decidual explants', Journal of Paediatrics and Child Health (2012) [E3]
2012 Pringle KG, Wang Y, Sykes SD, Lumbers ER, 'Fetal sex affects the expression of the renin angiotensin system in intra-uterine tissues', Journal of Paediatrics and Child Health (2012) [E3]
2012 Sykes SD, Pringle KG, Zhou A, Dekker GA, Roberts CT, Lumbers ER, 'Fetal sex affects the renin angiotensin system and the aetiology of gestational hypertension and preeclampsia', Journal of Paediatrics and Child Health (2012) [E3]
2011 Mitchell CM, Sykes SD, Pringle KG, Lumbers ER, Hirst JJ, Bisits AJ, Zakar T, 'Methylation of CpG Islands in the promoters of proinflammatory and steroid receptor genes in the human amnion, decidua and placenta', Reproductive Sciences (2011) [E3]
Co-authors Jon Hirst
2010 Conquest AL, Pringle KG, Logan P, Mitchell MD, Lumbers ER, 'PLZF: The missing link in decidualisation?', 24th Fetal and Neonatal Physiology Workshop of Australia and New Zealand. Program and Abstracts (2010) [E3]
2010 Mitchell CM, Bisits AM, Sykes SD, Pringle KG, Lumbers ER, Zakar T, 'CPG island methylation of proinflammatory and steroid receptor gene promoters in the human amnion', The Endocrine Society of Australia Annual Scientific Meeting Proceedings and Abstract Book (2010) [E3]
2010 Lumbers ER, Pringle KG, Marques FZ, Hirst JJ, Markus MA, Morris BJ, et al., 'Identification of renin-angiotensin system (RAS) in human fetal membranes, decidua and placenta and the effects of gender and labour', Hypertension (2010) [E3]
Co-authors Jon Hirst
2010 Pringle KG, Zakar T, Hirst JJ, Lumbers ER, 'Evidence that the renin angiotensin system is involved in early placentation', Journal of Paediatrics and Child Health: Abstracts of the 14th Annual Congress of the Perinatal Society of Australia and New Zealand 2010 (2010) [E3]
Co-authors Jon Hirst
2010 Lumbers ER, Pringle KG, Logan PC, Mitchell MD, 'Epigenetic regulation of prorenin and other components of the decidual renin angiotensin system (RAS)', Journal of Paediatrics and Child Health: Abstracts of the 14th Annual Congress of the Perinatal Society of Australia and New Zealand 2010 (2010) [E3]
2010 Pringle KG, Conquest AL, Mitchell CM, Zakar T, Lumbers ER, 'The Prorenin Receptor/PLZF Pathway in Human Amnion', Reproduction, Fertility and Development (2010) [E3]
2010 Mitchell CM, Zakar T, Sykes SD, Pringle KG, Lumbers ER, 'Methylation of Genes of the Renin Angiotensin System (RAS) in Early Human Amnion', Reproduction, Fertility and Development (2010) [E3]
2010 Marques FZ, Pringle KG, Markus MA, Conquest AL, Hirst JJ, Sarris M, et al., 'Molecular characterization of renin-angiotensin system components in human intrauterine tissues and fetal membranes from vaginal delivery and cesarean section', Reproduction, Fertility and Development (2010) [E3]
DOI 10.1016/j.placenta.2010.12.006
Co-authors Jon Hirst
2010 Sykes SD, Lumbers ER, Pringle KG, Zakar T, Dekker GA, Roberts CT, 'Predicting Gestational Hypertension and Preeclampsia from Maternal Angiotensin II and Angiotensin 1-7 Levels at 15 Weeks Gestation', Reproduction, Fertility and Development (2010) [E3]
2010 Sykes SD, Lumbers ER, Pringle KG, Zakar T, Dekker GA, Roberts CT, 'Predicting Gestational Diabetes From Maternal Angiotensin II and Angiotensin 1-7 Levels at 15 Weeks Gestation', Reproduction, Fertility and Development (2010) [E3]
2010 Wang Y, Pringle KG, Chen Y, Zakar T, Lumbers ER, 'Regulation of the Renin Angiotensin System (RAS) in a Trophoblast Cell Line by Cyclic Adenosine Monophosphate (CAMP) and 5'-AZA-2'-Deoxycytidine (AZA)', Reproduction, Fertility and Development (2010) [E3]
2009 Lumbers ER, Pringle KG, Roach DM, Mitchell CM, Hirst JJ, Markus A, et al., 'The identification and role of the intrauterine (Pro)renin/(Pro)renin receptor angiotensin system in prostaglandin synthesis in pregnancy', Reproductive Sciences (2009) [E3]
Co-authors Jon Hirst
2009 Pringle KG, Hirst JJ, Mitchell CM, Zakar T, Lumbers ER, 'The mechanism of prorenin induced PGHS-2 expression in the amnion', Reproductive Sciences (2009) [E3]
Co-authors Jon Hirst
2009 Pringle KG, Hirst JJ, Conquest AL, Mitchell CM, Zakar T, Lumbers ER, 'The role of prorenin in amnion PGHS-2 expression and the induction of labour', Journal of Paediatrics and Child Health (2009) [E3]
DOI 10.1111/j.1440-1754.2009.01474.x
Co-authors Jon Hirst
2008 Pringle KG, Roach DM, Mitchell CM, Hirst JJ, Zakar T, Lumbers ER, 'The intrauterine (pro)renin/(pro)renin receptor system and its role in prostaglandin synthesis during pregnancy', 51st Annual Scientific Meeting of the Endocrine Society of Australia and Society of Reproductive Biology: Meeting Proceedings and Abstract Book (2008) [E3]
Co-authors Jon Hirst
2008 Pringle KG, Kind KL, Thompson JG, Roberts CT, 'IGF-II, UPA and plasminogen, in combination, improve mouse embryo development and implantation rate', ASMR XVII NSW Scientific Meeting Programme and Abstracts (2008) [E3]
Show 45 more conferences

Other (1 outputs)

Year Citation Altmetrics Link
2016 Pringle K, Rae KM, 'The Art of Pregnancy', ( issue.March). VIC: Control Publications (2016)
Co-authors Kym Rae
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Grants and Funding

Summary

Number of grants 18
Total funding $1,821,155

Click on a grant title below to expand the full details for that specific grant.


20163 grants / $178,490

DVC(RI) Research Support for Future Fellowship (FT15)$135,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Doctor Kirsty Pringle
Scheme Future Fellowship Support
Role Lead
Funding Start 2016
Funding Finish 2019
GNo G1600525
Type Of Funding Internal
Category INTE
UON Y

Characterisation of the Prorenin/(Pro)Renin Receptor System in Early Placentation$21,745

Funding body: John Hunter Hospital Charitable Trust

Funding body John Hunter Hospital Charitable Trust
Project Team Doctor Kirsty Pringle, Dr Chris Wake
Scheme Research Grant
Role Lead
Funding Start 2016
Funding Finish 2016
GNo G1600314
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Angiotensin system inhibitors potentiate the efficacy of bevacizumab in the treatment of cancer$21,745

Funding body: John Hunter Hospital Charitable Trust

Funding body John Hunter Hospital Charitable Trust
Project Team Professor Eugenie Lumbers, Conjoint Associate Professor Anthony Proietto, Professor Rodney Scott, Doctor Kirsty Pringle
Scheme Research Grant
Role Investigator
Funding Start 2016
Funding Finish 2016
GNo G1600598
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

20155 grants / $804,318

Investigation of the mechanisms underlying successful placentation$693,286

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Doctor Kirsty Pringle
Scheme Future Fellowships
Role Lead
Funding Start 2015
Funding Finish 2019
GNo G1500940
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Susan Alberti PhD Scholarship$81,210

Funding body: Susan Alberti Medical Research Foundation

Funding body Susan Alberti Medical Research Foundation
Project Team Doctor Kirsty Pringle, Doctor Kym Rae, Dr Adrienne Gordon
Scheme Postgraduate Scholarship
Role Lead
Funding Start 2015
Funding Finish 2017
GNo G1500948
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Expression of Adrenoceptor Subtypes in Preterm and Term Hearts$25,222

Funding body: John Hunter Hospital Charitable Trust

Funding body John Hunter Hospital Charitable Trust
Project Team Doctor Kirsty Pringle, Dr Barbara Lingwood, Dr Chris Wake, Conjoint Professor Ian Wright
Scheme Research Grant
Role Lead
Funding Start 2015
Funding Finish 2015
GNo G1500118
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Equal Futures Award$2,600

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Kirsty Pringle
Scheme Equal Futures Award
Role Lead
Funding Start 2015
Funding Finish 2015
GNo G1600220
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Society of Reproductive Investigation 62nd Annual Scientific Meeting, San Fran USA, 25-28 March 2015$2,000

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Doctor Kirsty Pringle
Scheme Travel Grant
Role Lead
Funding Start 2015
Funding Finish 2015
GNo G1500275
Type Of Funding Internal
Category INTE
UON Y

20144 grants / $699,870

An early indicator of renal dysfunction in Indigenous women at risk of pregnancy complications $645,358

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Doctor Kirsty Pringle, Professor Eugenie Lumbers, Doctor Kym Rae, Professor Fiona Broughton-Pipkin, Laureate Professor Roger Smith
Scheme Project Grant
Role Lead
Funding Start 2014
Funding Finish 2016
GNo G1300183
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

A new therapeutic strategy for the treatment of endometriosis$27,512

Funding body: John Hunter Hospital Charitable Trust

Funding body John Hunter Hospital Charitable Trust
Project Team Doctor Eric Wang, Doctor Mohamed Galal, Doctor Kirsty Pringle, Professor Eugenie Lumbers
Scheme Research Grant
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1400553
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Does a novel biomarker of renal function in pregnant Indigenous Australian women predict their future renal and cardiovascular health?$25,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor Eugenie Lumbers, Doctor Kirsty Pringle, Doctor Kym Rae, Laureate Professor Roger Smith
Scheme Project Grant
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1301370
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Gordon Conference on Angiotensins, Lucca Italy, 1-7 March 2014$2,000

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Doctor Kirsty Pringle
Scheme Travel Grant
Role Lead
Funding Start 2014
Funding Finish 2015
GNo G1400098
Type Of Funding Internal
Category INTE
UON Y

20132 grants / $29,809

Identification of a novel urinary biomarker to identify women at risk of developing preeclampsia$23,809

Funding body: John Hunter Hospital Charitable Trust

Funding body John Hunter Hospital Charitable Trust
Project Team Doctor Kirsty Pringle, Doctor Mohamed Galal, Professor Eugenie Lumbers
Scheme Research Grant
Role Lead
Funding Start 2013
Funding Finish 2013
GNo G1300969
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Early Career PULSE Travel Award 2012$6,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Kirsty Pringle
Scheme Project Grant
Role Lead
Funding Start 2013
Funding Finish 2013
GNo G1300202
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

20122 grants / $58,854

Drugs that act on the renin-angiotensin system; repositioning their therapeutic targets to endometrial cancer$34,454

Funding body: John Hunter Hospital Charitable Trust

Funding body John Hunter Hospital Charitable Trust
Project Team Professor Eugenie Lumbers, Doctor Kirsty Pringle, Dr Henry Murray
Scheme Research Grant
Role Investigator
Funding Start 2012
Funding Finish 2012
GNo G1200650
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

The role of the intrarenal renin angiotensin system in preeclampsia and gestational hypertension$24,400

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Kirsty Pringle, Professor Eugenie Lumbers
Scheme Project Grant
Role Lead
Funding Start 2012
Funding Finish 2012
GNo G1101206
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

20111 grants / $25,000

Role of the renin-angiotensin system in pregnancies complicated by placental insufficiency$25,000

Funding body: John Hunter Hospital Charitable Trust

Funding body John Hunter Hospital Charitable Trust
Project Team Doctor Kirsty Pringle, Professor Eugenie Lumbers, Professor Ian Symonds
Scheme Research Grant
Role Lead
Funding Start 2011
Funding Finish 2012
GNo G1100637
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

20091 grants / $24,814

The role of prorenin in the first trimester placenta: Key to pregnancy success$24,814

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Kirsty Pringle, Professor Eugenie Lumbers, Conjoint Professor Tamas Zakar
Scheme Project Grant
Role Lead
Funding Start 2009
Funding Finish 2009
GNo G0189797
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y
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Research Supervision

Number of supervisions

Completed2
Current5

Total current UON EFTSL

PhD2.8

Current Supervision

Commenced Level of Study Research Title / Program / Supervisor Type
2016 PhD The Impact of Nutrition, Obesity and Diabetes on Maternal Kidney Function and Fetal Kidney Development in Indigenous and Non-Indigenous Australians.
PhD (Human Physiology), Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2016 PhD The Role of Prorenin and the Prorenin Receptor in Successful Placentation
PhD (Medical Biochemistry), Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2016 PhD The Role of miRNAs in Placental Development and Function: Implications for Pregnancies Complicated by Placental Insufficiency
PhD(Experimental Pharmacology), Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2015 PhD The Role of Intrauterine Tissue Renin-Angiotensin Systems in Pregnancy and Reproductive Health
PhD (Human Physiology), Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2014 PhD The Renin Angiotensin System in Endometrial Cancer
PhD (Human Physiology), Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor

Past Supervision

Year Level of Study Research Title / Program / Supervisor Type
2014 PhD The Circulating, Intrauterine and Intrarenal Renin Angiotensin Systems in Normal and Pathological Pregnancies
PhD (Human Physiology), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2013 PhD Regulation of the Uteroplacental Renin-Angiotensin System in Human Pregnancy
PhD (Human Physiology), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
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News

Placenta receptor could hold key to mammalian reproduction

December 16, 2015

A critical placenta receptor that could prevent life-threatening chronic disease will become the focus of University of Newcastle (UON) researcher, Dr Kirsty Pringle, after securing more than $690,000 under the prestigious Australian Research Council (ARC) Future Fellowship scheme.

The Conversation

Kidney disease in Aboriginal Australians perpetuates poverty

June 10, 2013

By Roger Smith, Director of the Mothers and Babies Research Centre, University of Newcastle and Kirsty Pringle, University of Newcastle

The recent death of the lead singer of Yothu Yindi, is a high-profile example of an event all too common in Aboriginal Australia.

Dr Kirsty Pringle

Position

ARC Future Fellow
Mothers and Babies Research Centre
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

Focus area

Pharmacy and Experimental Pharmacology

Contact Details

Email kirsty.pringle@newcastle.edu.au
Phone (02) 4042 0372
Fax (02) 4042 0034
Link Twitter

Office

Room Level 3 East W3-095
Building Hunter Medical Research Institute
Location Other

,
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