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Conjoint Professor Keith Jones

Conjoint Professor

School of Biomedical Sciences and Pharmacy (Human Physiology)

Career Summary

Biography

Meiosis is the name given to the two cell divisions germ cells go through following DNA replication in order to produce haploid gametes. Our research focuses on mammalian female meiosis where we use imaging based techniques (Fluorescent Protein chimeras) to explore this process in real-time. We argue that this is an important strategy when examining a dynamic process such as the meiotic cell cycle. Meiosis is important to study because of its unique cell division; in terms of understanding a fundamental cellular developmental biology process; and also because errors in meiotic division lead to aneuploid embryos, the leading cause of early pregnancy loss in humans and the cause of Down's Syndrome. Research Highlights: The mammalian oocyte spends most of its life arrested at prophase of the first meiotic division and we found that APCcdh1 activity was necessary in order to achieve this arrest (Reis et al., Nature Cell Biology, 2006). Recently we extended these observations to show that APCcdh1 also functioned in prometaphase to prevent aneuploidy in maturing oocytes (Reis et al., Nature Cell Biology, 2007). In the first meiotic division chromosome homologues are separated, a unique cell division, and in 2006 we found that during this division separase is needed to inhibit MPF activity (Gorr et al., Nature Cell Biology, 2006. See Nature Cell Biology, News & Views). Following exit from the first meiotic division the egg re-arrests at metaphase of the second meiotic division until sperm break this arrest with a cytosolic calcium signal. Re-arrest at metaphase of the second meiotic division requires the APC inhibitor Emi2 (Madgwick et al., Journal of Cell Biology, 2006).

At fertilization the sister chromatids are separated. Another unequal cell division occurs, and the second polar body is extruded. The fertilized oocyte completes meiosis and forms a zygote. We are very much interested in how the two meiotic divisions are controlled at a molecular level. Our approach is to over-express and visualise gene products by tagging them with a toolkit of Fluorescent Proteins (Cyan; Cerulean; Yellow, Green; Venus; and Red Fluorescent Proteins) and knock them out using antisense morpholinos.

Research Expertise
Mammalian reproductive biology, especially female reproduction with emphasis on oocytes and the meiotic divisions. Cell division and early embryo development, such as the transition from meiosis to mitosis, and the embryonic divisions leading up to implantation. Mitotic cell divisions of cultured cells, and the control of M-phase. Mis-segregation of chromosomes that lead to aneuploidy. Control of the meiotic divisions of oocytes with focus on the mechanisms that control faithful chromosome segregation such as the Spindle Assembly Checkpoint.









Qualifications

  • Doctor of Philosophy, University of Liverpool - UK
  • Bachelor of Science (Biochemistry)(Honours), University of Leeds - UK

Keywords

  • Cell Cycle
  • Cell Division
  • Chromosomes
  • Female Fertility
  • Meiosis
  • Mitosis
  • Oocytes
  • Ovarian Biology
  • Reproductive Biology

Fields of Research

CodeDescriptionPercentage
060699Physiology not elsewhere classified45
111499Paediatrics and Reproductive Medicine not elsewhere classified20
060199Biochemistry and Cell Biology not elsewhere classified35

Professional Experience

UON Appointment

DatesTitleOrganisation / Department
1/02/2008 - 31/12/2012ProfessorUniversity of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Chapter (3 outputs)

YearCitationAltmetricsLink
2013Jones KT, Lane SIR, Holt JE, 'Start and Stop Signals of Oocyte Meiotic Maturation', Oogenesis, Springer, London 183-193 (2013) [B1]
DOI10.1007/978-0-85729-826-3_13
Co-authorsJanet Holt
2013Holt JE, Lane SIR, Jones KT, 'The Control of Meiotic Maturation in Mammalian Oocytes', Gametogenesis, Academic Press, San diego 207-226 (2013) [B1]
DOI10.1016/B978-0-12-416024-8.00007-6Author URL
CitationsScopus - 8Web of Science - 8
Co-authorsJanet Holt
2011Jones KT, 'Anaphase-promoting complex control in female mouse meiosis', Cell Cycle in Development, Springer, Berlin 343-363 (2011) [B1]

Journal article (51 outputs)

YearCitationAltmetricsLink
2014Yun Y, Lane SIR, Jones KT, 'Premature dyad separation in meiosis II is the major segregation error with maternal age in mouse oocytes', DEVELOPMENT, 141 199-208 (2014) [C1]
DOI10.1242/dev.100206Author URL
CitationsScopus - 4Web of Science - 4
2014Holt JE, Pye V, Boon E, Stewart JL, Garcia-Higuera I, Moreno S, et al., 'The APC/C activator FZR1 is essential for meiotic prophase I in mice', DEVELOPMENT, 141 1354-U327 (2014) [C1]
DOI10.1242/dev.104828Author URL
CitationsScopus - 1Web of Science - 1
Co-authorsJanet Holt, Eileen Mclaughlin
2014Yun Y, Holt JE, Lane SIR, McLaughlin EA, Merriman JA, Jones KT, 'Reduced ability to recover from spindle disruption and loss of kinetochore spindle assembly checkpoint proteins in oocytes from aged mice', Cell Cycle, 13 1938-1947 (2014) [C1]

Currently, maternal aging in women, based on mouse models, is thought to raise oocyte aneuploidy rates, because chromosome cohesion deteriorates during prophase arrest, and Sgo2, a protector of centromeric cohesion, is lost. Here we show that the most common mouse strain, C57Bl6/J, is resistant to maternal aging, showing little increase in aneuploidy or Sgo2 loss. Instead it demonstrates significant kinetochore-associated loss in the spindle assembly checkpoint protein Mad2 and phosphorylated Aurora C, which is involved in microtubule-kinetochore error correction. Their loss affects the fidelity of bivalent segregation but only when spindle organization is impaired during oocyte maturation. These findings have an impact clinically regarding the handling of human oocytes ex vivo during assisted reproductive techniques and suggest there is a genetic basis to aneuploidy susceptibility. © 2014 Landes Bioscience.

DOI10.4161/cc.28897
CitationsScopus - 3Web of Science - 2
Co-authorsJanet Holt, Eileen Mclaughlin
2014Lane SIR, Jones KT, 'Non-canonical function of spindle assembly checkpoint proteins after APC activation reduces aneuploidy in mouse oocytes', NATURE COMMUNICATIONS, 5 (2014) [C1]
DOI10.1038/ncomms4444Author URL
CitationsWeb of Science - 2
2013Merriman JA, Lane SIR, Holt JE, Jennings PC, Garcia-Higuera I, Moreno S, et al., 'Reduced Chromosome Cohesion Measured by Interkinetochore Distance Is Associated with Aneuploidy Even in Oocytes from Young Mice', Biology of Reproduction, 88 31-31 (2013) [C1]
DOI10.1095/biolreprod.112.104786
CitationsScopus - 4Web of Science - 4
Co-authorsJanet Holt, Eileen Mclaughlin
2013Lord T, Nixon B, Jones KT, Aitken RJ, 'Melatonin Prevents Postovulatory Oocyte Aging in the Mouse and Extends the Window for Optimal Fertilization In Vitro', Biology of Reproduction, 88 1-9 (2013) [C1]
DOI10.1095/biolreprod.112.106450Author URL
CitationsScopus - 8Web of Science - 6
Co-authorsBrett Nixon, John Aitken
2013Holt JE, Lane SIR, Jones KT, 'Time-lapse epifluorescence imaging of expressed cRNA to cyclin B1 for studying meiosis i in mouse oocytes', Methods in Molecular Biology, 957 91-106 (2013) [C2]

The first meiotic division of mammalian oocytes physiologically occurs in the ovary in the hours preceding ovulation. Fortunately, oocytes removed from their follicular environment will readily undergo this process in culture. Their large size, optical transparency, and efficiency in translating exogenous cRNA make mouse oocytes very amenable to study this process in detail using fluorescence imaging-based techniques. Here we describe the process of microinjecting cRNA to proteins of interest that have been coupled to a fluorescent protein using cyclin B1 as an example. © 2013 Springer Science+Business Media, LLC.

DOI10.1007/978-1-62703-191-2-6
CitationsScopus - 1
Co-authorsJanet Holt
2013Jamsai D, O'Connor AE, DeBoer KD, Clark BJ, Smith SJ, Browne CM, et al., 'Loss of GGN Leads to Pre-Implantation Embryonic Lethality and Compromised Male Meiotic DNA Double Strand Break Repair in the Mouse', PLOS ONE, 8 (2013) [C1]
DOI10.1371/journal.pone.0056955Author URL
CitationsScopus - 1Web of Science - 2
2012Merriman-Jones JA, Jennings PC, McLaughlin EA, Jones KT, 'Effect of aging on superovulation efficiency, aneuploidy rates, and sister chromatid cohesion in mice aged up to 15 months', Biology of Reproduction, 86 1-6 (2012) [C1]
CitationsScopus - 22Web of Science - 21
Co-authorsEileen Mclaughlin
2012Jones KT, Lane SI, 'Chromosomal, metabolic, environmental, and hormonal origins of aneuploidy in mammalian oocytes', Experimental Cell Research, 318 1394-1399 (2012) [C1]
CitationsScopus - 21Web of Science - 19
2012Liu W, Yin J, Zhao G, Yun Y, Wu S, Jones KT, Lei A, 'Differential regulation of cyclin B1 degradation between the first and second meiotic divisions of bovine oocytes', Theriogenology, 78 1171.e1-1181.e1 (2012) [C1]
CitationsWeb of Science - 1
2012Jones KT, Robertson SA, Aitken RJ, 'Reactive oxygen species and sperm function-in sickness and in health', Journal of Andrology, 33 1096-1106 (2012) [C1]
CitationsScopus - 35Web of Science - 29
Co-authorsJohn Aitken
2012Lane SI, Yun Y, Jones KT, 'Timing of anaphase-promoting complex activation in mouse oocytes is predicted by microtubule-kinetochore attachment but not by bivalent alignment or tension', Development (Cambridge), 139 1947-1955 (2012) [C1]
CitationsScopus - 32Web of Science - 32
2012Jones KT, 'Meiosis: Mouse eggs do their anaphase topsy-turvy', Current Biology, 22 R153-R155 (2012) [C3]
2012Holt JE, Lane SI, Jennings PC, Garcia-Higuera I, Moreno S, Jones KT, 'APC FZR1 prevents nondisjunction in mouse oocytes by controlling meiotic spindle assembly timing', Molecular Biology of the Cell, 23 3970-3981 (2012) [C1]
CitationsScopus - 9Web of Science - 9
Co-authorsJanet Holt
2012Seah KYM, Holt JE, Garcia-Higuera I, Moreno S, Jones KT, 'The APC activator fizzy-related-1 (FZR1) is needed for preimplantation mouse embryo development', Journal of Cell Science, 125 6030-6037 (2012) [C1]
Co-authorsJanet Holt
2012Yuen WS, Merriman-Jones JA, O'Bryan MK, Jones KT, 'DNA double strand breaks but not interstrand crosslinks prevent progress through meiosis in fully grown mouse oocytes', PLOS One, 7 e43875 (2012) [C1]
CitationsScopus - 9Web of Science - 9
2011Lane SI, Jones KT, 'Phosphorylation of histone H3 in 1- and 2-cell embryos', Cell Cycle, 10 17-18 (2011) [C3]
DOI10.4161/cc.10.1.14221
2011Chang H-Y, Jennings PC, Stewart JL, Verrills NM, Jones KT, 'Essential role of protein phosphatase 2A in metaphase II arrest and activation of mouse eggs shown by okadaic acid, dominant negative protein phosphatase 2A, and FTY720', Journal of Biological Chemistry, 286 14705-14712 (2011) [C1]
DOI10.1074/jbc.M110.193227
CitationsScopus - 18Web of Science - 18
Co-authorsNikki Verrills
2011Jamsai D, Sarraj MA, Merriner DJ, Drummond AE, Jones KT, McLachlan RI, O'Bryan MK, 'GGN1 in the testis and ovary and its variance within the Australian fertile and infertile male population', International Journal of Andrology, 34 624-632 (2011) [C1]
CitationsScopus - 4Web of Science - 5
2011Jennings PC, Merriman-Jones JA, Beckett EL, Hansbro PM, Jones KT, 'Increased zona pellucida thickness and meiotic spindle disruption in oocytes from cigarette smoking mice', Human Reproduction, 26 878-884 (2011) [C1]
DOI10.1093/humrep/deq393
CitationsScopus - 16Web of Science - 13
Co-authorsPhilip Hansbro
2011Holt JE, Tran SM-T, Stewart JL, Minahan KL, Garcia-Higuera I, Moreno S, Jones KT, 'The APC/C activator FZR1 coordinates the timing of meiotic resumption during prophase I arrest in mammalian oocytes', Development, 138 905-913 (2011) [C1]
DOI10.1242/dev.059022
CitationsScopus - 18Web of Science - 16
Co-authorsJanet Holt
2010Jones KT, Holt JE, 'BubR1 highlights essential function of Cdh1 in mammalian oocytes', Cell Cycle, 9 1029-1030 (2010) [C3]
Co-authorsJanet Holt
2010Holt JE, Stewart JL, Jones KT, 'Spatial regulation of APC(Cdh1)-induced cyclin B1 degradation maintains G2 arrest in mouse oocytes', Development, 137 1297-1304 (2010) [C1]
DOI10.1242/dev.047555
CitationsScopus - 31Web of Science - 26
Co-authorsJanet Holt
2010Jones KT, 'Cohesin and Cdk1: An anaphase barricade', Nature Cell Biology, 12 106-108 (2010) [C3]
DOI10.1038/ncb0210-106
CitationsScopus - 3Web of Science - 3
2010Lane SI, Chang H-Y, Jennings PC, Jones KT, 'The Aurora kinase inhibitor ZM447439 accelerates first meiosis in mouse oocytes by overriding the spindle assembly checkpoint', Reproduction, 140 521-530 (2010) [C1]
DOI10.1530/REP-10-0223
CitationsScopus - 34Web of Science - 28
2009Chang H-Y, Minahan KL, Merriman-Jones JA, Jones KT, 'Calmodulin-dependent protein kinase gamma 3 (CamKII[gamma]3) mediates the cell cycle resumption of metaphase II eggs in mouse', Development, 136 4077-4081 (2009) [C1]
DOI10.1242/dev.042143
CitationsScopus - 28Web of Science - 25
2009Holt JE, Jones KT, 'Control of homologous chromosome division in the mammalian oocyte', Molecular Human Reproduction, 15 139-147 (2009) [C1]
DOI10.1093/molehr/gap007
CitationsScopus - 31Web of Science - 30
Co-authorsJanet Holt
2008Jones KT, 'Meiosis in oocytes: predisposition to aneuploidy and its increased incidence with age', Human Reproduction Update, 14 143-158 (2008) [C1]
DOI10.1093/humupd/dmm043
CitationsScopus - 98Web of Science - 94
2008Nabti I, Reis A, Levasseur M, Stemmann O, Jones KT, 'Securin and not CDK1/cyclin B1 regulates sister chromatid disjunction during meiosis II in mouse eggs', Developmental Biology, 321 379-386 (2008) [C1]
DOI10.1016/j.ydbio.2008.06.036
CitationsScopus - 16Web of Science - 16
2007Madgwick S, Jones KT, 'How eggs arrest at metaphase II: MPF stabilisation plus APC/C inhibition equals Cytostatic Factor', Cell Division, 2 1-7 (2007) [C1]
DOI10.1186/1747-1028-2-4
2007Reis A, Madgwick S, Chang H-Y, Nabti I, Levasseur M, Jones KT, 'Prometaphase APCcdh1 activity prevents non-disjunction in mammalian oocytes', Nature Cell Biology, 9 1192-1198 (2007) [C1]
DOI10.1038/ncb1640
2007Jones KT, Swann K, 'Composition of sea urchin egg homogenate determines its potency to inositol trisphosphate and cyclic ADPRibose-induced Ca2+ release', Biochemical and Biophysical Research Communications, 360 815-820 (2007) [C1]
DOI10.1016/j.bbrc.2007.06.134
2007Levasseur M, Carroll M, Jones KT, McDougall A, 'A novel mechanism controls the Ca2+ oscillations triggered by activation of ascidian eggs and has an absolute requirement for Cdk1 activity', Journal of Cell Science, 120 1763-1771 (2007) [C1]
DOI10.1242/jcs.003012
2007Gardner AJ, Knott JG, Jones KT, Evans JP, 'CaMKII can participate in but is not sufficient for the establishment of the membrane block to polyspermy in mouse eggs', Journal of Cellular Physiology, 212 275-280 (2007) [C1]
DOI10.1002/jcp.21046
CitationsScopus - 15
2007Jones KT, 'Intracellular calcium in the fertilization and development of mammalian eggs', Journal of Cellular Physiology, 34 1084-1089 (2007) [C1]
DOI10.1111/j.1440-1681.2007.04726.x
2006Madgwick S, Hansen DV, Levasseur M, Jackson PK, Jones KT, 'Mouse Emi2 Is Required to Enter Meiosis II by Reestablishing Cyclin B1 During Interkinesis', The Journal of Cell Biology, 174 791-801 (2006) [C1]
DOI10.1083/jcb.200604140
2006Gorr IH, Reis A, Boos D, Wühr M, Madgwick S, Jones KT, Stemmann O, 'Essential CDK1-inhibitory role for separase during meiosis I in vertebrate oocytes', Nature Cell Biology, 8 1035-1037 (2006) [C1]
DOI10.1038/ncb1467
2006Reis A, Chang H-Y, Levasseur M, Jones KT, 'APCcdh1 activity in mouse oocytes prevents entry into the first meiotic division', Nature Cell Biology, 8 539-540 (2006) [C1]
2006Reis A, Levasseur M, Chang H-Y, Elliot DJ, Jones KT, 'The CRY box: A second APCcdh1-dependent degron in mammalian cdc20', EMBO Reports, 7 1040-1045 (2006) [C1]
DOI10.1038/sj.embor.7400772
2006Knott JG, Gardner AJ, Madgwick S, Jones KT, Williams CJ, Schultz RM, 'Calmodulin-dependent protein kinase II triggers mouse egg activation and embryo development in the absence of Ca2+ oscillations', Developmental Biology, 296 388-395 (2006) [C1]
DOI10.1016/j.ydbio.2006.06.004
CitationsScopus - 43
2005Madgwick S, Levasseur M, Jones KT, 'Calmodulin-dependent protein kinase II, and not protein kinase C, is sufficient for triggering cell-cycle resumption in mammalian eggs', Journal of Cell Science, 118 3849-3859 (2005) [C1]
DOI10.1242/jcs.02506
2005Coward K, Ponting CP, Chang H-Y, Hibbitt O, Savolainen P, Jones KT, Parrington J, 'Phospholipase C{zeta}, the trigger of egg activation in mammals, is present in a non-mammalian species', Reproduction, 130 157-163 (2005) [C1]
DOI10.1530/rep.1.00707
2005Jones KT, 'Mammalian egg activation: from Ca2+ spiking to cell cycle progression', Reproduction, 130 813-823 (2005) [C1]
DOI10.1530/rep.1.00710
2004Hyslop LA, Nixon VL, Levasseur M, Chapman F, Chiba K, McDougall A, et al., 'Ca2+-promoted cyclin B1 degradation in mouse oocytes requires the establishment of a metaphase arrest', Developmental Biology, 269 206-219 (2004) [C1]
DOI10.1016/j.ydbio.2004.01.030
2004Madgwick S, Nixon VL, Chang H-Y, Herbert M, Levassuer M, Jones KT, 'Maintenance of sister chromatid attachment in mouse eggs through maturation-promoting factor activity', Developmental Biology, 275 68-81 (2004) [C1]
DOI10.1016/j.ydbio.2004.07.024
2004Chang H-Y, Levasseur M, Jones KT, 'Degradation of APCcdc20 and APCcdh1 substrates during the second meiotic division in mouse eggs', Journal of Cell Science, 117 6289-6296 (2004) [C1]
DOI10.1242/jcs.01567
2004Venables JP, Dalgliesh C, Paronetto MP, Skitt L, Thornton JK, Saunders PT, et al., 'SIAH1 targets the alternative splicing factor T-STAR for degradation by the proteasome', Human Molecular Genetics, 13 1525-1534 (2004) [C1]
DOI10.1093/hmg/ddh165
2004Jones KT, 'Turning it on and off: M-phase promoting factor during meiotic maturation and fertilization', Molecular Human Reproduction, 10 1-5 (2004) [C1]
DOI10.1093/molehr/gah009
2003Carroll M, Levasseur M, Whitaker M, Jones KT, McDougall A, 'Exploring the mechanism of action of the sperm-triggered calcium-wave pacemaker in ascidian zygotes', Journal of Cell Science, 116 4997-5004 (2003) [C1]
DOI10.1242/jcs.00846
2003Soeller C, Jacobs MD, Donaldson PJ, Cannell MB, Jones KT, Ellis-Davies GCR, 'Application of two-photon flash photolysis to reveal intercellular communication and intracellular Ca2+ movements.', Journal of Biomedical Optics, 8 418-427 (2003) [C1]
DOI10.1117/1.1582468
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Conference (5 outputs)

YearCitationAltmetricsLink
2010Chang H-Y, Jennings PC, Jones KT, 'The use of okadaic acid and FTY720 to examine the role of PP2A in the metaphase II arrest of mouse eggs', The American Society for Cell Biology 50th Annual Meeting Abstracts, Phildelphia, PA (2010) [E3]
2010Jones KT, 'CDH1: A cell cycle protein involved in female meiosis and prevention of aneuploidy', Reproduction, Fertility and Development, Sydney (2010) [E3]
DOI10.1071/SRB10Abs032
2010Hopkins LA, Pye VJ, Fraser BA, Holt JE, Jones KT, McLaughlin EA, 'The Role of Fizzy Related 1 in Male Meiosis', Reproduction, Fertility and Development, Sydney (2010) [E3]
Co-authorsEileen Mclaughlin, Janet Holt
2010Jennings PC, Jones KT, 'Investigating the Role of Cyclin A2 During Oocyte Meiosis', Reproduction, Fertility and Development, Sydney (2010) [E3]
2009Jones KT, Weaver J, Holt JE, 'The mechanism by which fizzy-related (Fzr1) controls pro-phase 1 arrest in mouse oocytes', Biology of Reproduction, Pittsburgh, PA (2009) [E3]
Co-authorsJanet Holt
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Grants and Funding

Summary

Number of grants28
Total funding$5,058,322

Click on a grant title below to expand the full details for that specific grant.


20123 grants / $652,134

Pregnancy and Reproduction MRSP 2011-12 $369,134

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamProfessor Roger Smith, Laureate Professor John Aitken, Conjoint Professor Keith Jones
SchemeNSW MRSP Infrastructure Grant
RoleInvestigator
Funding Start2012
Funding Finish2012
GNoG1101192
Type Of FundingOther Public Sector - State
Category2OPS
UONY

Regulation of the cell cycle by phosphorylation dependent targeting of CaMKII$20,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Nikki Verrills, Doctor Kathryn Skelding, Emeritus Professor John Rostas, Associate Professor Phillip Dickson, Conjoint Professor Keith Jones
SchemeNear Miss Grant
RoleInvestigator
Funding Start2012
Funding Finish2012
GNoG1200679
Type Of FundingInternal
CategoryINTE
UONY

20117 grants / $960,000

Gamete-specific knockout of Fizzy-Related to examine its meiotic role in oocytes and sperm$600,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamProfessor Eileen McLaughlin, Conjoint Professor Keith Jones, Professor Sergio Moreno
SchemeDiscovery Projects
RoleInvestigator
Funding Start2011
Funding Finish2011
GNoG1000020
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

An Advanced Mass Spectrometer for Applications in Phospho-Proteomics, Glycomics and Top-Down Sequencing of Proteins$250,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamDoctor Mark Baker, Laureate Professor John Aitken, Professor Roger Smith, Conjoint Professor Keith Jones, Conjoint Professor Ray Rose, Professor Lois Salamonsen
SchemeLinkage Infrastructure Equipment & Facilities (LIEF)
RoleInvestigator
Funding Start2011
Funding Finish2011
GNoG1000632
Type Of FundingScheme excluded from IGS
CategoryEXCL
UONY

SCIREQ FlexiVentFX system + FlexiVentFX extension$45,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Phil Hansbro, Laureate Professor Paul Foster, Professor Joerg Mattes, Doctor Simon Keely, Doctor Jay Horvat, Doctor Nicole Hansbro, Doctor Ming Yang, Doctor Catherine Ptaschinski, Doctor Kelly Asquith, Doctor Gough Au, Conjoint Professor Peter Wark, Laureate Professor John Aitken, Conjoint Professor Keith Jones, Professor Roger Smith, Professor Judith Black, Professor Rakesh Kumar, Professor Paul Hertzog
SchemeEquipment Grant
RoleInvestigator
Funding Start2011
Funding Finish2011
GNoG1100037
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

Factors affecting the quality of mammalian eggs when females age.$25,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamConjoint Professor Keith Jones
SchemeNear Miss Grant
RoleLead
Funding Start2011
Funding Finish2011
GNoG1001042
Type Of FundingInternal
CategoryINTE
UONY

Eppendorf mastercycler pro with thermomixer comfort and 5430R centrifuge$15,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Eileen McLaughlin, Professor Peter Lewis, Professor Adam McCluskey, Conjoint Professor Keith Jones, Associate Professor Brett Nixon, Doctor Shaun Roman, Doctor Jennette Sakoff, Doctor Ian Grainge, Doctor Janet Holt, Doctor Xiao Yang
SchemeEquipment Grant
RoleInvestigator
Funding Start2011
Funding Finish2011
GNoG1100028
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

An Advanced Mass Spectrometer for Applications in Phospho-Proteomics, Glycomics and Top-Down Sequencing of Proteins$15,000

Funding body: Prince Henry's Institute of Medical Research

Funding bodyPrince Henry's Institute of Medical Research
Project TeamDoctor Mark Baker, Laureate Professor John Aitken, Professor Roger Smith, Conjoint Professor Keith Jones, Conjoint Professor Ray Rose, Professor Lois Salamonsen
SchemeLinkage Infrastructure Equipment & Facilities (LIEF) Partner funding
RoleInvestigator
Funding Start2011
Funding Finish2011
GNoG1100844
Type Of FundingScheme excluded from IGS
CategoryEXCL
UONY

IMPLEN NanoPhotometer pearl$10,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamConjoint Associate Professor Murray Cairns, Associate Professor Paul Tooney, Professor Alan Brichta, Emeritus Professor John Rostas, Emeritus Professor Patricia Michie, Conjoint Professor Keith Jones, Professor Ulli Schall, Associate Professor Phillip Dickson, Doctor Frederick Walker, Doctor Rick Thorne, Doctor Chris Dayas, Doctor Nikki Verrills, Doctor Janet Holt, Doctor Severine Roselli, Doctor Kathryn Skelding, Doctor Jude Weidenhofer, Associate Professor Liz Milward, Doctor Charles De Bock, Doctor Julie Merriman-Jones, Doctor Jing Qin Wu, Doctor Bing Liu, Mr Dan Johnstone, Ms Belinda Goldie, Doctor Natalie Beveridge
SchemeEquipment Grant
RoleInvestigator
Funding Start2011
Funding Finish2011
GNoG1100030
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

20105 grants / $990,356

HMRI MRSP Infrastructure Grant (10-11) - PREGNANCY & REPRODUCTION$362,277

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamProfessor Roger Smith, Laureate Professor John Aitken, Conjoint Professor Keith Jones
SchemeNSW MRSP Infrastructure Grant
RoleInvestigator
Funding Start2010
Funding Finish2010
GNoG1100474
Type Of FundingOther Public Sector - State
Category2OPS
UONY

ABI 7500 Real Time PCR System $34,000

Funding body: NHMRC (National Health & Medical Research Council)

Electron Multiplier Charge-Coupled Device Camera. Hamamatsu EM-CCD Camera C9100-13$29,079

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamConjoint Professor Keith Jones, Professor Eileen McLaughlin, Professor Dirk Van Helden, Doctor Rick Thorne
SchemeEquipment Grant
RoleLead
Funding Start2010
Funding Finish2010
GNoG1000052
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

20099 grants / $2,045,437

The role of the Anaphase-Promoting Complex activator Cdh1 in mammalian oocytes and aneuploidy$506,250

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamConjoint Professor Keith Jones, Professor Eileen McLaughlin
SchemeProject Grant
RoleLead
Funding Start2009
Funding Finish2009
GNoG0188850
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Elucidation of the signalling pathways during fertilization in mammals$325,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamConjoint Professor Keith Jones, Dr Olaf Stemmann
SchemeDiscovery Projects
RoleLead
Funding Start2009
Funding Finish2009
GNoG0188824
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

HMRI MRSP Infrastructure Grant (09-10) Pregnancy and Reproduction$296,789

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamProfessor Roger Smith, Laureate Professor John Aitken, Conjoint Professor Keith Jones
SchemeNSW MRSP Infrastructure Grant
RoleInvestigator
Funding Start2009
Funding Finish2009
GNoG1000642
Type Of FundingOther Public Sector - State
Category2OPS
UONY

Confocal Laser Scanning Microscopy for Live Cell Imaging$275,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamConjoint Professor Keith Jones, Professor Eileen McLaughlin, Laureate Professor John Aitken, Conjoint Professor Ray Rose, Emeritus Professor John Patrick, Conjoint Professor Christina Offler, Associate Professor David McCurdy, Emeritus Professor Leonie Ashman, Professor Gordon Burns, Professor Dirk Van Helden, Doctor Nikki Verrills, Associate Professor Brett Nixon, Doctor Shaun Roman, Associate Professor Yong-Ling Ruan, Doctor Rick Thorne, Professor Mike Calford
SchemeLinkage Infrastructure Equipment & Facilities (LIEF)
RoleLead
Funding Start2009
Funding Finish2009
GNoG0189038
Type Of FundingScheme excluded from IGS
CategoryEXCL
UONY

Aging eggs: understanding the molecular mechanisms of declining female fertility$79,489

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamConjoint Professor Keith Jones, Professor Eileen McLaughlin
SchemeProject Grant
RoleLead
Funding Start2009
Funding Finish2009
GNoG0189795
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Leica VT1200S - Fully automated vibrating blade microtome$16,209

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Robert Callister, Professor Alan Brichta, Conjoint Professor Keith Jones, Professor Jon Hirst, Doctor Brett Graham, Associate Professor Philip Bolton, Doctor Phil Jobling, Associate Professor Paul Tooney, Doctor Angela McPherson, Doctor Rebecca Lim, Doctor Ramatis De Oliveira, Mr Matthew Walsh
SchemeEquipment Grant
RoleInvestigator
Funding Start2009
Funding Finish2009
GNoG0189842
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

GRC Fertilization and Egg Activation, Plymouth USA, 12-17 July 2009$1,700

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding bodyUniversity of Newcastle - Faculty of Health and Medicine
Project TeamConjoint Professor Keith Jones
SchemeTravel Grant
RoleLead
Funding Start2009
Funding Finish2009
GNoG0190133
Type Of FundingInternal
CategoryINTE
UONY

20084 grants / $410,395

The function of gametogenenin in male fertility and embryo genesis$230,500

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamConjoint Professor Keith Jones, Dr M O'Bryan
SchemeProject Grant
RoleLead
Funding Start2008
Funding Finish2008
GNoG0188417
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Olympus Fluoview FV1000-IX81 Microscope$141,970

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamConjoint Professor Keith Jones
SchemeEquipment Grant
RoleLead
Funding Start2008
Funding Finish2008
GNoG0188673
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

Colibri high-performance LED illumination system for fluorescence live cell microscopy$23,225

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamDoctor Rick Thorne, Dr Charles De Bock, Professor Xu Dong Zhang, Doctor Lisa Lincz, Professor Gordon Burns, Conjoint Professor Peter Hersey, Professor Dirk Van Helden, Conjoint Professor Keith Jones, Professor Roger Smith
SchemeEquipment Grant
RoleInvestigator
Funding Start2008
Funding Finish2008
GNoG0188545
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

Programmed mammalian oocyte activation: the production line model of primordial follicle development$14,700

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Eileen McLaughlin, Conjoint Professor Keith Jones
SchemePilot Grant
RoleInvestigator
Funding Start2008
Funding Finish2008
GNoG0189084
Type Of FundingInternal
CategoryINTE
UONY
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Research Supervision

Past Supervision

YearResearch Title / Program / Supervisor Type
2015Susceptibility of Mammalian Oocytes to Chromosome Segregation Errors with Maternal Aging
Human Biology, Faculty of Health and Medicine
Co-Supervisor
2013Role of Fzr1 in Embryogenesis
Human Biology, Faculty of Health and Medicine
Principal Supervisor
2013DNA Repair and the Fanconi Anemia Pathway: Insights into Female Meiosis and Mitosis
Human Biology, Faculty of Health and Medicine
Principal Supervisor
2012Control of Chromosome Segregation in Mouse Oocytes
Human Biology, Faculty of Health and Medicine
Principal Supervisor
2012Characterisation of an Oocyte Specific Knockout Model of Cdh1
Human Biology, Faculty of Health and Medicine
Principal Supervisor
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Conjoint Professor Keith Jones

Position

Conjoint Professor
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

Focus area

Human Physiology

Contact Details

Emailkeith.jones@newcastle.edu.au
Phone(02) 4921 6682
Fax(02) 4921 7903

Office

RoomMS612
BuildingMedical Sciences
LocationCallaghan
University Drive
Callaghan, NSW 2308
Australia
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