Dr Katie Ashton

Casual Academic

School of Medicine and Public Health (Medical Genetics)

Career Summary

Biography

Research Expertise
Molecular genetics and pathology of cancer.

Teaching Expertise
Student Supervision o University of Newcastle, Australia Bachelor of Biotechnology (1 Student) Research Assistant July 2008 - current o University of Newcastle, Australia Bachelor of Biomedical Sciences (2 Students) Work Experience and Student Placement (HUBS3409) December 2008 - February 2009 and July 2009 - November 2009 o University of Tromsø, Norway Master of Pharmacy (2 Exchange Students) 6 month research project to complete their studies November 2008 - May 2009 Casual Academic o Computer Lab Tutor § HUBS2409 Introduction to Online Databases July 2008 § HUBS1202 Human Genomics September 2009 - November 2009

Administrative Expertise
2009 - HMRI New Building Lab Coordinator I represented the Information-Based Medicine group at the HMRI new building meetings for the design of the laboratory space. 2009 - Mentor/Mentee Program This program was introduced at the beginning of 2009 to improve mentoring within the School of Biomedical Sciences and Pharmacy, University of Newcastle, Australia. I was involved as a mentee within this program and was assigned a mentor who was a senior researcher within the school. 2008 - Interviewed by the Newcastle Herald "Out of School" Success Story The title of the article was "Cancer Crusader" which outlined my development into a successful cancer researcher in the Hunter Region.

Collaborations
The molecular mechanisms of UV-light induced skin cancers Base excision repair in melanoma Nucleotide excision repair in melanoma Genetic variation and endometrial cancer risk.

Qualifications

  • PhD, University of Newcastle
  • Bachelor of Science (Biotechnology), University of Newcastle
  • Bachelor of Science (Biotechnology)(Honours), University of Newcastle

Keywords

  • Bioinformatics
  • Cancer Genetics
  • Endometrial Cancer
  • Gene Expression Profiling
  • Genetics
  • HNPCC
  • Melanoma
  • Mutations
  • Polymorphisms
  • Skin Cancer
  • UV-light Radiation

Fields of Research

Code Description Percentage
111299 Oncology and Carcinogenesis not elsewhere classified 100

Professional Experience

UON Appointment

Title Organisation / Department
Casual Academic University of Newcastle
School of Medicine and Public Health
Australia

Membership

Dates Title Organisation / Department
1/01/2009 -  Membership - American Association for Cancer Research American Association for Cancer Research
1/01/2009 -  Membership - Australasian Microarray and Associated Technologies Association Australasian Microarray and Associated Technologies Association
Australia
1/01/2009 -  Membership - Hunter Medical Research Institute Cancer Research Program Hunter Medical Research Institute Cancer Research Program
Australia
1/01/2005 -  Membership - Australian Society for Medical Research The Australian Society for Medical Research
1/01/2004 -  Membership - Human Genetics Society of Australasia Human Genetics Society of Australasia (HGSA)
Australia

Awards

Distinction

Year Award
2003 Faculty of Science and Information Technology Commendation List for Outstanding Achievement
University of Newcastle

Research Award

Year Award
2010 HMRI PULSE Education Prize
Hunter Medical Research Institute
2008 HMRI Bogner Cancer Research Fellow
Hunter Medical Research Institute
2006 HMRI Jennie Thomas Special Competitive Research Fund for Early Career Researchers in Cancer
Hunter Medical Research Institute
2005 Australian Postgraduate Award
University of Newcastle
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Journal article (27 outputs)

Year Citation Altmetrics Link
2016 Bowden NA, Smyth M, Jaaback K, Ashton KA, Scurry J, 'Genetic changes correlate with histopathology in a benign, borderline and malignant mucinous ovarian tumour', Journal of Obstetrics and Gynaecology, 36 119-121 (2016) [C3]
DOI 10.3109/01443615.2015.1036406
Co-authors Nikola Bowden
2016 Thompson DJ, O'Mara TA, Glubb DM, Painter JN, Cheng T, Folkerd E, et al., 'CYP19A1 fine-mapping and Mendelian randomization: Estradiol is causal for endometrial cancer', Endocrine-Related Cancer, 23 77-91 (2016) [C1]

© 2016 The authors.Candidate gene studies have reported CYP19A1 variants to be associated with endometrial cancerandwith estradiol (E2) concentrations.We analyzed2937singlenucleo... [more]

© 2016 The authors.Candidate gene studies have reported CYP19A1 variants to be associated with endometrial cancerandwith estradiol (E2) concentrations.We analyzed2937singlenucleotidepolymorphisms (SNPs) in 6608 endometrial cancer cases and 37 925 controls and report the first genome widesignificant association between endometrial cancer and a CYP19A1 SNP (rs727479 in intron 2, P=4.8×10-11). SNP rs727479 was also among those most strongly associated with circulating E2 concentrations in 2767 post-menopausal controls (P=7.4×10-8). The observed endometrial cancer odds ratio per rs727479 A-allele (1.15, CI=1.11-1.21) is compatible with that predicted by theobservedeffectonE2 concentrations (1.09, CI=1.03-1.21), consistentwith the hypothesis that endometrial cancer risk is driven by E2. From 28 candidate-causal SNPs, 12 co-located with three putative gene-regulatory elements and their risk alleles associated with higher CYP19A1 expression in bioinformatical analyses. For both phenotypes, the associationswith rs727479 were stronger amongwomen with a higher BMI (PinteractionZ0.034 and 0.066 respectively), suggesting a biologically plausible gene-environment interaction.

DOI 10.1530/ERC-15-0386
Citations Scopus - 2
Co-authors Rodney Scott, John Attia, Liz Holliday, Mark Mcevoy
2015 Cheng TH, Thompson D, Painter J, O'Mara T, Gorman M, Martin L, et al., 'Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1.', Sci Rep, 5 17369 (2015) [C1]
DOI 10.1038/srep17369
Citations Scopus - 1
Co-authors Rodney Scott, Liz Holliday, John Attia, Mark Mcevoy
2015 Carvajal-Carmona LG, O Mara TA, Painter JN, Lose FA, Dennis J, Michailidou K, et al., 'Candidate locus analysis of the TERT¿CLPTM1L cancer risk region on chromosome 5p15 identifies multiple independent variants associated with endometrial cancer risk', Human Genetics, 134 231-245 (2015) [C1]

© 2014, The Author(s).Several studies have reported associations between multiple cancer types and single-nucleotide polymorphisms (SNPs) on chromosome 5p15, which harbours TERT ... [more]

© 2014, The Author(s).Several studies have reported associations between multiple cancer types and single-nucleotide polymorphisms (SNPs) on chromosome 5p15, which harbours TERT and CLPTM1L, but no such association has been reported with endometrial cancer. To evaluate the role of genetic variants at the TERT¿CLPTM1L region in endometrial cancer risk, we carried out comprehensive fine-mapping analyses of genotyped and imputed SNPs using a custom Illumina iSelect array which includes dense SNP coverage of this region. We examined 396 SNPs (113 genotyped, 283 imputed) in 4,401 endometrial cancer cases and 28,758 controls. Single-SNP and forward/backward logistic regression models suggested evidence for three variants independently associated with endometrial cancer risk (P¿=¿4.9¿×¿10-6 to P¿=¿7.7¿×¿10-5). Only one falls into a haplotype previously associated with other cancer types (rs7705526, in TERT intron 1), and this SNP has been shown to alter TERT promoter activity. One of the novel associations (rs13174814) maps to a second region in the TERT promoter and the other (rs62329728) is in the promoter region of CLPTM1L; neither are correlated with previously reported cancer-associated SNPs. Using TCGA RNASeq data, we found significantly increased expression of both TERT and CLPTM1L in endometrial cancer tissue compared with normal tissue (TERTP¿=¿1.5¿×¿10-18, CLPTM1LP¿=¿1.5¿×¿10-19). Our study thus reports a novel endometrial cancer risk locus and expands the spectrum of cancer types associated with genetic variation at 5p15, further highlighting the importance of this region for cancer susceptibility.

DOI 10.1007/s00439-014-1515-4
Citations Scopus - 6
Co-authors Rodney Scott
2015 Ashton KA, Scurry J, Tabrizi SN, Garland SM, Otton G, Bowden NA, 'The problem of late ovarian metastases from primary cervical adenocarcinoma.', Gynecologic oncology reports, 13 23-25 (2015) [C3]
Co-authors Nikola Bowden
2015 Bowden NA, Beveridge NJ, Ashton KA, Baines KJ, Scott RJ, 'Understanding xeroderma pigmentosum complementation groups using gene expression profiling after UV-light exposure', International Journal of Molecular Sciences, 16 15985-15996 (2015) [C1]

© 2015 by the authors; licensee MDPI, Basel, Switzerland.Children with the recessive genetic disorder Xeroderma Pigmentosum (XP) have extreme sensitivity to UV-light, a 10,000-fo... [more]

© 2015 by the authors; licensee MDPI, Basel, Switzerland.Children with the recessive genetic disorder Xeroderma Pigmentosum (XP) have extreme sensitivity to UV-light, a 10,000-fold increase in skin cancers from age 2 and rarely live beyond 30 years. There are seven genetic subgroups of XP, which are all resultant of pathogenic mutations in genes in the nucleotide excision repair (NER) pathway and a XP variant resultant of a mutation in translesion synthesis, POLH. The clinical symptoms and severity of the disease is varied across the subgroups, which does not correlate with the functional position of the affected protein in the NER pathway. The aim of this study was to further understand the biology of XP subgroups, particularly those that manifest with neurological symptoms. Whole genome gene expression profiling of fibroblasts from each XP complementation group was assessed before and after UV-light exposure. The biological pathways with altered gene expression after UV-light exposure were distinct for each subtype and contained oncogenic related functions such as perturbation of cell cycle, apoptosis, proliferation and differentiation. Patients from the subgroups XP-B and XP-F were the only subgroups to have transcripts associated with neuronal activity altered after UV-light exposure. This study will assist in furthering our understanding of the different subtypes of XP which will lead to better diagnosis, treatment and management of the disease.

DOI 10.3390/ijms160715985
Citations Scopus - 1
Co-authors Nikola Bowden, Rodney Scott, Katherine Baines
2015 Painter JN, O'Mara TA, Batra J, Cheng T, Lose FA, Dennis J, et al., 'Fine-mapping of the HNF1B multicancer locus identifies candidate variants that mediate endometrial cancer risk', HUMAN MOLECULAR GENETICS, 24 1478-1492 (2015) [C1]
DOI 10.1093/hmg/ddu552
Citations Scopus - 8Web of Science - 1
Co-authors John Attia, Rodney Scott, Liz Holliday, Mark Mcevoy
2015 O'Mara TA, Glubb DM, Painter JN, Cheng T, Dennis J, Australian National Endometrial Cancer Study Group (ANECS), et al., 'Comprehensive genetic assessment of the ESR1 locus identifies a risk region for endometrial cancer.', Endocr Relat Cancer, 22 851-861 (2015) [C1]
DOI 10.1530/ERC-15-0319
Citations Scopus - 3
Co-authors Mark Mcevoy, Rodney Scott, John Attia, Liz Holliday
2014 Ashton KA, Scurry J, Ouveysi A, Ebbs J, Jaaback K, Bowden NA, 'Transformation of endometrioid carcinoma to carcinoma with trophoblastic differentiation: clinicopathological and whole genomic study.', Pathology, 46 351-353 (2014) [C3]
DOI 10.1097/PAT.0000000000000101
Co-authors Nikola Bowden
2013 Talseth-Palmer B, Wijnen JT, Brenne IS, Jagmohan-Changur S, Barker DJ, Ashton KA, et al., 'Combined analysis of three Lynch syndrome cohorts confirms the modifying effects of 8q23.3 and 11q23.1 in MLH1 mutation carriers', International Journal of Cancer, 132 1487-1729 (2013) [C1]
Citations Scopus - 12Web of Science - 9
Co-authors Bente Talseth-Palmer, Rodney Scott
2013 Bowden NA, Ashton KA, Vilain RE, Avery-Kiejda KA, Davey RJ, Murray HC, et al., 'Regulators of Global Genome Repair Do Not Respond to DNA Damaging Therapy but Correlate with Survival in Melanoma', PLOS ONE, 8 (2013) [C1]
DOI 10.1371/journal.pone.0070424
Citations Scopus - 1Web of Science - 1
Co-authors Kelly Kiejda, Rodney Scott, Nikola Bowden, Xu Zhang
2012 Ashton KA, Scurry JP, Rutherford J, Otton GR, Scott R, Bowden NA, 'Nodular prurigo of the vulva', Pathology, 44 565-567 (2012) [C3]
Citations Scopus - 3Web of Science - 1
Co-authors Rodney Scott, Nikola Bowden
2011 Kiejda KA, Bowden NA, Croft AJ, Scurr LL, Kairupan CF, Ashton KA, et al., 'P53 in human melanoma fails to regulate target genes associated with apoptosis and the cell cycle and may contribute to proliferation', BMC Cancer, 11 203-219 (2011) [C1]
DOI 10.1186/1471-2407-11-203
Citations Scopus - 38Web of Science - 22
Co-authors Xu Zhang, Rodney Scott, Kelly Kiejda, Bente Talseth-Palmer, Nikola Bowden
2011 Talseth-Palmer B, Brenne IS, Ashton KA, Evans T-J, McPhillips M, Groombridge C, et al., 'Colorectal cancer susceptibility loci on chromosome 8q23.3 and 11q23.1 as modifiers for disease expression in lynch syndrome', Journal of Medical Genetics, 48 279-284 (2011) [C1]
DOI 10.1136/jmg.2010.079962
Citations Scopus - 27Web of Science - 20
Co-authors Bente Talseth-Palmer, Rodney Scott
2011 Australian Ntl Endometrial Cancer Study Group, Scott R, Ashton KA, Proietto AM, Otton GR, Ntl Study Of Endometrical Cancer Genetics Group, 'Genome-wide association study identifies a common variant associated with risk of endometrial cancer', Nature Genetics, 43 451-455 (2011) [C1]
DOI 10.1038/ng.812
Citations Scopus - 68Web of Science - 48
Co-authors Rodney Scott
2010 Proietto AM, Otton GR, Symonds IM, McEvoy MA, Attia JR, Gilbert M, et al., 'Polymorphisms in genes of the steroid hormone biosynthesis and metabolism pathways and endometrial cancer risk', Cancer Epidemiology, 34 328-337 (2010) [C1]
DOI 10.1016/j.canep.2010.03.005
Citations Scopus - 31Web of Science - 27
Co-authors Mark Mcevoy, Ian Symonds, Rodney Scott, John Attia
2010 Bowden NA, Ashton KA, Kiejda KA, Zhang XD, Hersey P, Scott R, 'Nucleotide excision repair gene expression after cisplatin treatment in melanoma', Cancer Research, 70 7918-7926 (2010) [C1]
Citations Scopus - 10Web of Science - 7
Co-authors Nikola Bowden, Xu Zhang, Kelly Kiejda, Rodney Scott
2010 Ashton KA, Proietto AM, Otton GR, Symonds IM, McEvoy MA, Attia JR, Scott R, 'Toll-Like Receptor (TLR) and Nucleosome-binding Oligomerization Domain (NOD) gene polymorphisms and endometrial cancer risk', BMC Cancer, 10 1-7 (2010) [C1]
DOI 10.1186/1471-2407-10-382
Citations Scopus - 26Web of Science - 24
Co-authors Ian Symonds, Mark Mcevoy, John Attia, Rodney Scott
2009 Ashton KA, Proietto AM, Otton GR, Symonds IM, McEvoy MA, Attia JR, et al., 'Estrogen receptor polymorphisms and the risk of endometrial cancer', BJOG: An International Journal of Obstetrics and Gynaecology, 116 1053-1061 (2009) [C1]
DOI 10.1111/j.1471-0528.2009.02185.x
Citations Scopus - 30Web of Science - 26
Co-authors Rodney Scott, John Attia, Mark Mcevoy, Ian Symonds
2009 Ashton KA, Proietto AM, Otton GR, Symonds IM, Scott R, 'Genetic variants in MUTYH are not associated with endometrial cancer risk', Hereditary Cancer in Clinical Practice, 7 1-5 (2009) [C1]
DOI 10.1186/1897-4287-7-3
Citations Scopus - 7Web of Science - 6
Co-authors Ian Symonds, Rodney Scott
2009 Ashton KA, Proietto AM, Otton GR, Symonds IM, McEvoy MA, Attia JR, et al., 'Polymorphisms in TP53 and MDM2 combined are associated with high grade endometrial cancer', Gynecologic Oncology, 113 109-114 (2009) [C1]
DOI 10.1016/j.ygyno.2008.12.036
Citations Scopus - 28Web of Science - 26
Co-authors Rodney Scott, John Attia, Mark Mcevoy, Ian Symonds
2008 Ashton KA, Proietto AM, Otton GR, Symonds IM, McEvoy MA, Attia JR, et al., 'The influence of the Cyclin D1 870 G>A polymorphism as an endometrial cancer risk factor', BMC Cancer, 8 1-6 (2008) [C1]
DOI 10.1186/1471-2407-8-272
Citations Scopus - 8Web of Science - 6
Co-authors Rodney Scott, John Attia, Mark Mcevoy, Ian Symonds
2008 Talseth-Palmer B, Ashton KA, Meldrum C, Suchy J, Kurzawski G, Lubinski J, Scott R, 'Aurora-A and Cyclin D1 polymorphisms and the age of onset of colorectal cancer in hereditary nonpolyposis colorectal cancer', International Journal of Cancer, 122 1273-1277 (2008) [C1]
DOI 10.1002/ijc.23177
Citations Scopus - 23Web of Science - 19
Co-authors Rodney Scott, Bente Talseth-Palmer
2008 Dunning AM, Pooley KA, Chang-Claude J, Easton DF, Peto J, Houlston R, et al., 'Association of a common AKAP9 variant with breast cancer risk: A collaborative analysis', Journal of the National Cancer Institute, 100 437-442 (2008) [C1]
DOI 10.1093/jnci/djn037
Citations Scopus - 25Web of Science - 21
2006 Ashton KA, Meldrum CJ, McPhillips ML, Suchy J, Kurzawski G, Lubinski J, Scott R, 'The association of the COMT V158M polymorphism with endometrial/ovarian cancer in HNPCC families adhering to the Amsterdam criteria', Hereditary Cancer in Clinical Practice, 4 94-102 (2006) [C1]
DOI 10.1186/1897-4287-4-2-94
Citations Scopus - 2
Co-authors Rodney Scott
2005 Ashton KA, Meldrum CJ, McPhillips ML, Kairupan CF, Scott R, 'Frequency of the common MYH mutations (G382D and Y165C) in MMR mutation positive and negative HNPCC patients', Hereditary Cancer in Clinical Practice, 3 65-70 (2005) [C1]
DOI 10.1186/1897-4287-3-2-65
Citations Scopus - 10Web of Science - 8
Co-authors Rodney Scott
2004 Scott R, Ashton KA, 'Familial breast and bowel cancer: Does it exist?', Hereditary Cancer in Clinical Practice, 2 25-59 (2004) [C1]
DOI 10.1186/1897-4287-2-1-25
Co-authors Rodney Scott
Show 24 more journal articles

Conference (29 outputs)

Year Citation Altmetrics Link
2014 Warren CFA, Ashton KA, Vilain RE, Braye SG, Moscato P, Bowden NA, 'Association of BCL-2B expression with increased survival and response to stress in melanoma suggests a functional role for this previously uncharacterised isoform.', Keystone Symposia on Molecular and Cellular Biology (2014) [E3]
Co-authors Nikola Bowden, Pablo Moscato
2014 Warren CFA, Ashton KA, Vilain RE, Braye SG, Moscato P, Bowden NA, 'A functional role in cellular stress response and melanoma pathology for the previously uncharacterised isoform, Bcl-2B.', Proceedings of the Inaugural EMBL Australia PhD Symposium (2014) [E3]
Co-authors Pablo Moscato, Nikola Bowden
2014 Budden T, Davey RJ, Vilain RE, Ashton KA, Braye SG, Scott RJ, Bowden NA, 'Repair of UVB-induced DNA damage is reduced in melanoma due to attenuated XPC and global genome repair.', Proceedings of the Inaugural EMBL Australia PhD Symposium (2014) [E3]
Co-authors Nikola Bowden, Rodney Scott
2014 Davey RJ, Budden T, Vilain RE, Ashton KA, Braye SG, Scott RJ, Bowden NA, 'REPAIR OF UVB-INDUCED DNA DAMAGE IS REDUCED IN MELANOMA DUE TO ATTENUATED XPC AND GLOBAL GENOME REPAIR', ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY (2014)
Co-authors Nikola Bowden, Rodney Scott
2014 Davey RJ, Budden T, Vilain RE, Ashton KA, Braye SG, Scott RJ, Bowden NA, 'REPAIR OF UVB-INDUCED DNA DAMAGE IS REDUCED IN MELANOMA DUE TO ATTENUATED XPC AND GLOBAL GENOME REPAIR', ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY (2014) [E3]
Co-authors Rodney Scott, Nikola Bowden
2014 Warren C, Ashton KA, Vilain RE, Braye SG, Moscato P, Bowden NA, 'A FUNCTIONAL ROLE IN MELANOMA PATHOLOGY AND CELLULAR RESPONSE TO STRESS FOR THE PREVIOUSLY UNCHARACTERISED ISOFORM, BCL2B', ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY (2014) [E3]
Co-authors Pablo Moscato, Nikola Bowden
2014 Davey RJ, Vilain RE, Ashton KA, Braye SG, Scott RJ, Bowden NA, 'XPC expression is associated with BRAFV600E and NRASQ61R mutations and poor survival in melanoma.', ASMR Satellite scientific meeting proceedings (2014) [E3]
Co-authors Nikola Bowden, Rodney Scott
2014 Warren C, Ashton KA, Vilain RE, Braye SG, Moscato P, Bowden NA, 'The expression of the previously uncharacterised isoform, Bcl-2B is associated with increased survival in melanoma.', ASMR Satellite scientific meeting proceedings (2014) [E3]
Co-authors Pablo Moscato, Nikola Bowden
2013 Talseth-Palmer B, Meldrum C, Ashton KA, Spigelman A, Scott RJ, 'Revealing cancer complexity - Identification of Lynch syndrome cases', Familial Cancer (2013) [E3]
Co-authors Bente Talseth-Palmer, Rodney Scott
2012 Talseth-Palmer B, Wijen J, Brenne I, Jagomohan-Changur S, Baker D, Ashton KA, et al., 'Colorectal cancer risk modification in Lynch syndrome', Human Genome Meeting 2012: Genetics and Genomics in Personalised Medicine. Abstract Book (2012) [E3]
Co-authors Bente Talseth-Palmer, Rodney Scott
2011 Bowden NA, Ashton KA, Kiejda KA, Zhang XD, Hersey P, Scott R, 'Downstream effects of reduction in nucleotide excision repair in response to cisplatin treatment in melanoma', Pigment Cell & Melanoma Research (2011) [E3]
DOI 10.1111/j.1755-148X.2011.00909.x
Co-authors Rodney Scott, Xu Zhang, Kelly Kiejda, Nikola Bowden
2011 Talseth-Palmer B, Wijnen JT, Brenne IS, Jagmohan-Changur S, Ashton KA, Tops CM, et al., 'Chromosome 8q23.3, 10p14 and 11q23.1 variants modify colorectal cancer risk in Lynch syndrome - a combined analysis of the Australian, Dutch and Polish Lynch syndrome cohorts', Familial Aspects of Cancer: Research and Practice 2011 (2011) [E3]
Co-authors Bente Talseth-Palmer, Rodney Scott
2011 Talseth-Palmer B, Wijnen JT, Brenne IS, Jagmohan-Changur S, Ashton KA, Tops CM, et al., 'Chromosome 8q23.3 AND 11q23.1 variants modify colorectal cancer risk in Lynch syndrome: A meta-analysis of the Dutch and Australian Lynch syndrome cohorts', Abstracts: 4th Biennial Meeting: International Society for Gastrointestinal Hereditary Tumours (2011) [E3]
Co-authors Rodney Scott, Bente Talseth-Palmer
2010 Bowden NA, Ashton KA, Kiejda KA, Zhang XD, Hersey P, Scott R, 'Altered nucleotide excision repair gene expression after cisplatin treatment in melanoma', AACR 101st Annual Meeting 2010. Abstracts (2010) [E3]
DOI 10.1158/0008-5472.CAN-10-0161
Co-authors Kelly Kiejda, Nikola Bowden, Rodney Scott, Xu Zhang
2010 Ashton KA, Bowden NA, Kairupan CF, Kiejda KA, Zhang XD, Hersey P, Scott R, 'Base excision repair and gene expression profiling in malignant melanoma', Sydney Cancer Conference 2010. Profiling Risk, Personalising Treatment and Predicting Outcomes. Conference Program and Abstract Book (2010) [E3]
Co-authors Xu Zhang, Kelly Kiejda, Rodney Scott, Nikola Bowden
2010 Evans T-J, Talseth-Palmer B, Brenne IS, Ashton KA, McPhillips M, Groombridge C, et al., 'Colorectal cancer suspectibility loci on chr 8q23.3 and 11q23.1 as modifiers for disease expression in Lynch syndrome', Sydney Cancer Conference 2010. Profiling Risk, Personalising Treatment and Predicting Outcomes. Conference Program and Abstract Book (2010) [E3]
Co-authors Bente Talseth-Palmer, Rodney Scott
2010 Ashton KA, Bowden NA, Vilain RE, Kairupan CF, Kiejda KA, Zhang XD, et al., 'Genetic variation of the base excision repair gene, MUTYH, and melanoma development', Melanoma 2010 Congress. Oral and Poster Abstracts (2010) [E3]
Co-authors Kelly Kiejda, Xu Zhang, Nikola Bowden
2010 Bowden NA, Ashton KA, Kiejda KA, Vilain RE, Braye SG, Kairupan CF, et al., 'Nucleotide excision repair gene expression in melanoma', Melanoma 2010 Congress. Oral and Poster Abstracts (2010) [E3]
DOI 10.1158/0008-5472.CAN-10-0161
Co-authors Xu Zhang, Kelly Kiejda, Nikola Bowden
2010 Vilain RE, Ashton KA, Bowden NA, Braye SG, Ashman LK, Scott RJ, 'Clinicopathological and gene expression profiling of advanced melanoma harbouring KIT and common kinase mutations', Melanoma 2010 Congress. Oral and Poster Abstracts (2010) [E3]
Co-authors Leonie Ashman, Nikola Bowden
2009 Bowden NA, Ashton KA, Stibbard GJ, Cox MB, Baines KJ, Scott R, 'Predicting xeroderma pigmentosum complementation group by gene expression profiling', AMATA 2009 (2009) [E3]
Co-authors Rodney Scott, Katherine Baines, Nikola Bowden
2009 Kairupan CF, Bowden NA, Ashton KA, Zhang XD, Hersey P, Scott R, 'Gene expression profiling in malignant melanoma', AMATA 2009 (2009) [E3]
Co-authors Xu Zhang, Rodney Scott, Nikola Bowden
2008 Bowden NA, Ashton KA, Kiejda KA, Zhang XD, Hersey P, Scott R, 'Altered nucleotide excision repair gene expression after cisplatin treatment in melanoma', Proceedings of the Australian Health and Medical Research Congress 2008 (2008) [E3]
Co-authors Xu Zhang, Nikola Bowden, Kelly Kiejda, Rodney Scott
2008 Ashton KA, Proietto AM, Otton GR, Symonds IM, McEvoy MA, Attia JR, et al., 'Combined tp53 r72p and mdm2 snp309 genotypes are associated with high grade endometrial cancer', ASMR XVII NSW Scientific Meeting: Programme and Abstracts (2008) [E3]
Co-authors Mark Mcevoy, Rodney Scott, Ian Symonds, John Attia
2008 Bowden NA, Ashton KA, Baines KJ, Cox MB, Scott R, 'Altered gene expression after UV-light induced DNA damage', Conference on Translational Cancer Research: Abstracts (2008) [E3]
Co-authors Nikola Bowden, Katherine Baines, Rodney Scott
2008 Ashton KA, Proietto AM, Otton GR, Hamann U, Scott R, 'The genetic basis of endometrial cancer', Conference on Translational Cancer Research: Abstracts (2008) [E3]
Co-authors Rodney Scott
2008 Ashton KA, Proietto AM, Otton GR, Hamann U, Scott R, 'The genetic basis of endometrial cancer', Keystone Symposia on Molecular and Cellular Biology: Abstract Book (2008) [E3]
Co-authors Rodney Scott
2006 Ashton KA, Meldrum CJ, McPhillips ML, Suchy J, Kurzawski G, Lubinski J, Scott R, 'Are polymorphisms in the toll-like receptors associated with disease risk in HNPCC?', 11th International Human Genetics: Final Program (2006) [E3]
Co-authors Rodney Scott
2005 Ashton KA, Talseth-Palmer B, Meldrum CJ, McPhillips ML, Scott R, 'COMT polymorphism (V158M) and its association with endometrial cancer in HNPCC families that adhere to the Amsterdam or Bethesda criteria', Human Genetics Society of Australasia 29th Annual Conference (2005) [E3]
Co-authors Bente Talseth-Palmer, Rodney Scott
2005 Talseth-Palmer B, Meldrum C, Ashton KA, Scott R, 'Age of disease onset in HNPCC patients is more complex than that predicted by R72P polymorphism in TP53', Human Genetics Society of Australasia 29th Annual Conference (2005) [E3]
Co-authors Rodney Scott, Bente Talseth-Palmer
Show 26 more conferences
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Grants and Funding

Summary

Number of grants 5
Total funding $189,000

Click on a grant title below to expand the full details for that specific grant.


20112 grants / $125,000

A molecular genetic investigation of MUTYH in melanoma progression$90,000

Funding body: Cure Cancer Australia Foundation

Funding body Cure Cancer Australia Foundation
Project Team Doctor Katie Ashton
Scheme Postdoctoral Fellowship
Role Lead
Funding Start 2011
Funding Finish 2011
GNo G1000855
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Nucleotide excision repair gene expression in melanoma$35,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Nikola Bowden, Doctor Katie Ashton, Doctor Stephen Braye, Professor Rodney Scott, Dr Ricardo Vilain
Scheme Project Grant
Role Investigator
Funding Start 2011
Funding Finish 2011
GNo G1001057
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

20101 grants / $4,000

Pulse - Education Prize$4,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Katie Ashton
Scheme PULSE Education Prize
Role Lead
Funding Start 2010
Funding Finish 2010
GNo G0900131
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

20091 grants / $45,000

Gene expression profiling of Xeroderma pigmentosum$45,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor Rodney Scott, Doctor Nikola Bowden, Doctor Katie Ashton
Scheme Postdoctoral Fellowship
Role Investigator
Funding Start 2009
Funding Finish 2010
GNo G0900194
Type Of Funding Donation - Aust Non Government
Category 3AFD
UON Y

20061 grants / $15,000

Genetic susceptibility in Endometrial Cancer$15,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Katie Ashton, Professor Rodney Scott
Scheme Special Competitive Research Fund for Early Career Researchers in Cancer
Role Lead
Funding Start 2006
Funding Finish 2006
GNo G0186110
Type Of Funding Not Known
Category UNKN
UON Y
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Dr Katie Ashton

Position

Casual Academic
Centre for Bioinformatics, Biomarker Discovery and Information-Based Medicine
School of Medicine and Public Health
Faculty of Health and Medicine

Focus area

Medical Genetics

Contact Details

Email katie.ashton@newcastle.edu.au
Phone (02) 40420282
Fax (02) 40420031

Office

Room HMRI Level 3 West
Building Hunter Medical Research Institute
Location John Hunter Hospital

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