Dr Katie Baines

Postdoctoral Research Fellow

School of Medicine and Public Health

Career Summary

Biography

Dr Baines is a post doctoral researcher in the Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, and the Priority Research Centre for Asthma and Respiratory Disease. Her second 3 year post-doctoral fellowship commenced in January 2012 through The University of Newcastle, and prior to this she received a research fellowship through (2008-11) funded through Xstrata Coal and HMRI. As an early career post doctoral researcher; Dr Baines manages a semi independent molecular mechanisms group within Professor Peter Gibson’s laboratory. Dr Baines interest in respiratory medicine began when she commenced PhD studies in late 2003 (awarded in 2008), on molecular mechanisms involved in the pathogenesis of noneosinophilic asthma, particularly involving neutrophils. Throughout her PhD she was supported with scholarships from The Asthma Foundation of NSW and the Asthma CRC. Dr Baines is committed to furthering a full-time career in medical research. Her research interests surround the role of gene-environment interactions in the development and pathogenesis of respiratory diseases including asthma and COPD. Dr Baines research uses high throughput genomics technologies to understand more about molecular mechanisms, particularly phenotype definition, biomarker identification and the relationship of phenotypes to clinical outcomes and treatment responses. She is also interested in how respiratory disease phenotypes evolve over time, with regard to the impact of medication use such as inhaled corticosteroids and macrolides, and environmental exposures such as diet and microbial infection. Dr Baines research has led to a number of important contributions to the knowledge base particularly the role of neutrophils and gene expression in asthma and COPD. She has shown that airway neutrophils have an impaired innate immune response in asthma; however blood neutrophils are activated in the neutrophilic phenotype of asthma which is associated with systemic inflammation, a key feature of this phenotype. Dr Baines has defined transcriptional phenotypes of asthma using gene expression profiling of induced sputum and blood, proving the existence of phenotypes as well as the involvement of specific pathways (IL1 and TNF) in the pathogenesis of neutrophilic airway inflammation. Dr Baines has recently identified novel immune genes that are associated with rhinovirus infection of airway epithelial cells in COPD. Since 2009 Dr Baines has published >15 journal articles in highly ranked journals (Thorax, ERJ, JACI), that have been cited 138 times at present. She also has 2 book chapters, 1 Australian Provisional Patent and >38 conference abstracts. Dr Baines has obtained several awards, including the New and Emerging Researcher Awards in 2011 from the Australian Lung Foundation and the Thoracic Society of Australia and New Zealand. She has been awarded 7 competitive travel grant awards, including the esteemed Janet Elder Travel Grant in 2011 and the HMRI Pulse Education Prize in 2010. Dr Baines currently co-supervises 3 PhD students, and was primary supervisor to an honours student who received Class 1 honours in 2012. She is committed to providing a supportive environment for students to grow and learn the skills that will allow them to be successful in their independent research in the future.

Research Expertise

Katie is a laboratory based researcher with expertise in many laboratory methods, including using molecular techniques to understand more about the pathogenesis of respiratory diseases, including asthma and chronic obstructive pulmonary disease (COPD). She has particularl interest in using transcriptomics to understand how environmental influences in predisposed individuals can lead to the development of respiratory disease and different phenotypes of disease. She is also particularly interested in the role of inflammatory cells especially neutrophils in asthma and COPD, and the effects of environmental exposures including medications, diet and infection.

Collaborations
Dr Baines is involved in several successful collaborations, both locally and nationally. 1. Prof Anne Chang, Menzies School of Health and University of Queensland: A new multi-site study investigating airway and systemic markers and mechanisms of Protracted Bacterial Bronchitis in children. Subject of an NHMRC funded grant 2013-2016 2. Dr Manuel Ferreira, University of Queensland: Characterisation of the asthma transcriptome using RNA-seq. Subject of a UQ Collaborative Seed Funding Grant 2012. 3. Dr Brian Oliver and Prof Dominik Hartl, Woolcock Research Institute, University of Sydney, and University of Tubingen, Germany. Neutrophil responses to rhinovirus infection in asthma. Subject of a pending NHMRC grant for 2014. Local collaborations: 1. Prof Peter Gibson and Dr Jodie Simpson: Markers and Mechanisms of severe asthma inflammatory phenotypes. Subject of a NHMRC grant 2013-2015. 2. Dr Vanessa McDonald and Prof Peter Gibson: Phenotype based management of severe asthma. Funded by HMRI and John Hunter Hospital Charitable Trust 2012. 2. Dr Lisa Wood: Effects of diet, including antioxidant withdrawal and fatty acids on gene expression in asthma. 3. A/Prof Peter Wark: Rhinovirus infection and changes in gene expression in primary bronchial epithelial cells in COPD and asthma.

Qualifications

  • PhD, University of Newcastle
  • Bachelor of Biomedical Sciences, University of Newcastle
  • Bachelor of Biomedical Sciences (Hons), University of Newcastle

Keywords

  • Asthma
  • COPD
  • Epigenetics
  • Gene Expression
  • Inflammation
  • Innate Immunity
  • Neutrophils

Fields of Research

Code Description Percentage
110203 Respiratory Diseases 100

Professional Experience

UON Appointment

Title Organisation / Department
Postdoctoral Research Fellow University of Newcastle
School of Medicine and Public Health
Australia

Academic appointment

Dates Title Organisation / Department
1/01/2015 -  Fellow UON

UoN Research Fellowship

University of Newcastle
School of Medicine and Public Health
Australia
1/01/2012 -  Post Doctoral Research Fellow University of Newcastle
School of Medicine and Public Health
Australia
1/05/2008 - 1/12/2011 Post Doctoral Fellow University of Newcastle
School of Medicine and Public Health
Australia
1/04/2008 - 1/04/2011 Fellow

Hunter Medical Research Institute:- Project Grant

University of Newcastle
School of Medicine and Public Health
Australia
Edit

Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Chapter (2 outputs)

Year Citation Altmetrics Link
2013 Baines KJ, Simpson JL, Gibson PG, 'Chapter 17: Biology of Neutrophils.', Middleton¿s Allergy Principles and Practice., Elsevier, Philadelphia, PA, USA 280-291 (2013)
2009 Simpson JL, Baines KJ, Gibson PG, 'Biology of neutrophils', Middleton's Allergy: Principles & Practice, Mosby, Philadelphia, Pennsylvania 283-294 (2009) [B1]
Co-authors Peter Gibson, Jodie Simpson

Journal article (34 outputs)

Year Citation Altmetrics Link
2015 Scott HA, Latham JR, Callister R, Pretto JJ, Baines K, Saltos N, et al., 'Acute exercise is associated with reduced exhaled nitric oxide in physically inactive adults with asthma', Annals of Allergy, Asthma and Immunology, 114 470-479 (2015)

Background Although exercise has multiple health benefits, relatively little attention has been paid to its potential therapeutic effects in those with asthma. Objective To examin... [more]

Background Although exercise has multiple health benefits, relatively little attention has been paid to its potential therapeutic effects in those with asthma. Objective To examine the effects of acute exercise on inflammation in physically inactive and active adults with asthma. Methods Fourteen adults with asthma (n = 6 physically inactive, n = 8 physically active) completed (1) 30 minutes of moderate-intensity exercise on a treadmill and (2) 30 minutes of rest in random order, with 4 weeks between sessions. Exhaled nitric oxide (eNO) was measured before and after the intervention (0, 0.5, 1, 2, 4, and 24 hours). Blood inflammatory mediators were measured before and after the intervention (0, 2, and 24 hours). Results Physically inactive participants had a significant decrease in eNO 4 hours after exercise (-4.8 ppb, -6.4 to -0.5 ppb, P =.028), which was not observed in physically active participants (P =.362). Interluekin-1 receptor antagonist increased in the physically inactive group 2 hours after exercise, with this increase strongly correlated with the decrease in eNO at 4 hours (R = -0.685, P =.007) and 24 hours (R = -0.659, P =.014) after exercise. Interleukin-6 was increased significantly 2 hours after exercise in physically inactive participants. Blood neutrophils and nuclear factor erythroid 2-like 2 gene expression were increased 2 hours after exercise in the overall cohort. Conclusion This study demonstrates that acute moderate-intensity exercise is associated with decreased eNO in physically inactive adults with asthma and suggests that interluekin-1 receptor antagonist could have a role in mediating this effect. The attenuated response in physically active participants might be due to the sustained anti-inflammatory effects of exercise training. Future studies should investigate the impact of exercise intensity and exercise training on airway inflammation in those with asthma.

DOI 10.1016/j.anai.2015.04.002
Co-authors Robin Callister, Lisa Wood, Hayley Scott
2015 Baines KJ, Backer V, Gibson PG, Powel H, Porsbjerg CM, 'Impaired lung function is associated with systemic inflammation and macrophage activation.', Eur Respir J, 45 557-559 (2015) [C1]
DOI 10.1183/09031936.00187514
Co-authors Peter Gibson
2015 Gao P, Gibson PG, Baines KJ, Yang IA, Upham JW, Reynolds PN, et al., 'Anti-inflammatory deficiencies in neutrophilic asthma: reduced galectin-3 and IL-1RA/IL-1 beta', RESPIRATORY RESEARCH, 16 (2015)
DOI 10.1189/s12931-014-0163-5
Co-authors Jodie Simpson, Peter Gibson
2015 Scott HA, Latham JR, Callister R, Pretto JJ, Baines K, Saltos N, et al., 'Acute exercise is associated with reduced exhaled nitric oxide in physically inactive adults with asthma', Annals of Allergy, Asthma and Immunology, 114 470-479 (2015)

Background Although exercise has multiple health benefits, relatively little attention has been paid to its potential therapeutic effects in those with asthma. Objective To examin... [more]

Background Although exercise has multiple health benefits, relatively little attention has been paid to its potential therapeutic effects in those with asthma. Objective To examine the effects of acute exercise on inflammation in physically inactive and active adults with asthma. Methods Fourteen adults with asthma (n = 6 physically inactive, n = 8 physically active) completed (1) 30 minutes of moderate-intensity exercise on a treadmill and (2) 30 minutes of rest in random order, with 4 weeks between sessions. Exhaled nitric oxide (eNO) was measured before and after the intervention (0, 0.5, 1, 2, 4, and 24 hours). Blood inflammatory mediators were measured before and after the intervention (0, 2, and 24 hours). Results Physically inactive participants had a significant decrease in eNO 4 hours after exercise (-4.8 ppb, -6.4 to -0.5 ppb, P =.028), which was not observed in physically active participants (P =.362). Interluekin-1 receptor antagonist increased in the physically inactive group 2 hours after exercise, with this increase strongly correlated with the decrease in eNO at 4 hours (R = -0.685, P =.007) and 24 hours (R = -0.659, P =.014) after exercise. Interleukin-6 was increased significantly 2 hours after exercise in physically inactive participants. Blood neutrophils and nuclear factor erythroid 2-like 2 gene expression were increased 2 hours after exercise in the overall cohort. Conclusion This study demonstrates that acute moderate-intensity exercise is associated with decreased eNO in physically inactive adults with asthma and suggests that interluekin-1 receptor antagonist could have a role in mediating this effect. The attenuated response in physically active participants might be due to the sustained anti-inflammatory effects of exercise training. Future studies should investigate the impact of exercise intensity and exercise training on airway inflammation in those with asthma.

DOI 10.1016/j.anai.2015.04.002
Co-authors Hayley Scott, Lisa Wood, Robin Callister
2015 Baines KJ, Backer V, Gibson PG, Powell H, Porsbjerg CM, 'Investigating the effects of arctic dietary intake on lung health.', Eur J Clin Nutr, (2015)
DOI 10.1038/ejcn.2015.85
Co-authors Peter Gibson
2015 Bowden NA, Beveridge NJ, Ashton KA, Baines KJ, Scott RJ, 'Understanding xeroderma pigmentosum complementation groups using gene expression profiling after UV-light exposure', International Journal of Molecular Sciences, 16 15985-15996 (2015)

Children with the recessive genetic disorder Xeroderma Pigmentosum (XP) have extreme sensitivity to UV-light, a 10,000-fold increase in skin cancers from age 2 and rarely live bey... [more]

Children with the recessive genetic disorder Xeroderma Pigmentosum (XP) have extreme sensitivity to UV-light, a 10,000-fold increase in skin cancers from age 2 and rarely live beyond 30 years. There are seven genetic subgroups of XP, which are all resultant of pathogenic mutations in genes in the nucleotide excision repair (NER) pathway and a XP variant resultant of a mutation in translesion synthesis, POLH. The clinical symptoms and severity of the disease is varied across the subgroups, which does not correlate with the functional position of the affected protein in the NER pathway. The aim of this study was to further understand the biology of XP subgroups, particularly those that manifest with neurological symptoms. Whole genome gene expression profiling of fibroblasts from each XP complementation group was assessed before and after UV-light exposure. The biological pathways with altered gene expression after UV-light exposure were distinct for each subtype and contained oncogenic related functions such as perturbation of cell cycle, apoptosis, proliferation and differentiation. Patients from the subgroups XP-B and XP-F were the only subgroups to have transcripts associated with neuronal activity altered after UV-light exposure. This study will assist in furthering our understanding of the different subtypes of XP which will lead to better diagnosis, treatment and management of the disease.

DOI 10.3390/ijms160715985
Co-authors Nikola Bowden, Rodney Scott
2015 Scott HA, Latham JR, Callister R, Pretto JJ, Baines K, Saltos N, et al., 'Acute exercise is associated with reduced exhaled nitric oxide in physically inactive adults with asthma', Annals of Allergy, Asthma and Immunology, (2015)

Background: Although exercise has multiple health benefits, relatively little attention has been paid to its potential therapeutic effects in those with asthma. Objective: To exam... [more]

Background: Although exercise has multiple health benefits, relatively little attention has been paid to its potential therapeutic effects in those with asthma. Objective: To examine the effects of acute exercise on inflammation in physically inactive and active adults with asthma. Methods: Fourteen adults with asthma (n= 6 physically inactive, n= 8 physically active) completed (1) 30 minutes of moderate-intensity exercise on a treadmill and (2) 30 minutes of rest in random order, with 4 weeks between sessions. Exhaled nitric oxide (eNO) was measured before and after the intervention (0, 0.5, 1, 2, 4, and 24 hours). Blood inflammatory mediators were measured before and after the intervention (0, 2, and 24 hours). Results: Physically inactive participants had a significant decrease in eNO 4 hours after exercise (-4.8 ppb,-6.4 to-0.5 ppb, P= .028), which was not observed in physically active participants (P= .362). Interluekin-1 receptor antagonist increased in the physically inactive group 2 hours after exercise, with this increase strongly correlated with the decrease in eNO at 4 hours (R=-0.685, P= .007) and 24 hours (R=-0.659, P=.014) after exercise. Interleukin-6 was increased significantly 2 hours after exercise in physically inactive participants. Blood neutrophils and nuclear factor erythroid 2-like 2 gene expression were increased 2hours after exercise in the overall cohort. Conclusion: This study demonstrates that acute moderate-intensity exercise is associated with decreased eNO in physically inactive adults with asthma and suggests that interluekin-1 receptor antagonist could have a role in mediating this effect. The attenuated response in physically active participants might be due to the sustained anti-inflammatory effects of exercise training. Future studies should investigate the impact of exercise intensity and exercise training on airway inflammation in those with asthma. Trial registration: Australian New Zealand Clinical Trials Registry (http://www.anzctr.org.au), registration number ACTRN12613001014741.

DOI 10.1016/j.anai.2015.04.002
Co-authors Robin Callister, Hayley Scott, Lisa Wood
2015 Bowden N, Beveridge N, Ashton K, Baines K, Scott R, 'Understanding Xeroderma Pigmentosum Complementation Groups Using Gene Expression Profiling after UV-Light Exposure', International Journal of Molecular Sciences, 16 15985 (2015)
2015 Fu J-J, McDonald VM, Baines KJ, Gibson PG, 'Airway IL-1ß and systemic inflammation as predictors of future exacerbation risk in asthma and COPD', CHEST Journal, (2015)
DOI 10.1378/chest.14-2337
Co-authors Vanessa Mcdonald
2014 Baines KJ, Upham JW, Yerkovich ST, Chang AB, Marchant JM, Carroll M, et al., 'Mediators of neutrophil function in children with protracted bacterial bronchitis', Chest, 146 1013-1020 (2014) [C1]
DOI 10.1378/chest.14-0131
Citations Scopus - 2Web of Science - 2
Co-authors Peter Gibson, Jodie Simpson
2014 Simpson JL, Baines KJ, Ryan N, Gibson PG, 'Neutrophilic asthma is characterised by increased rhinosinusitis with sleep disturbance and GERD', Asian Pacific Journal of Allergy and Immunology, 32 66-74 (2014) [C1]

Background: Asthma is a heterogeneous inflammatory disease and eosinophilic, noneosinophilic and neutrophilic forms are recognised. While clinically similar to eosinophilic asthma... [more]

Background: Asthma is a heterogeneous inflammatory disease and eosinophilic, noneosinophilic and neutrophilic forms are recognised. While clinically similar to eosinophilic asthma, patients with non-eosinophilic asthma have different responses to treatment and little is known about the triggers of symptoms and inflammation. Objective: This study sought to characterise asthma control, exacerbation frequency and potential triggers of non-eosinophilic and specifically neutrophilic asthma such as infection, gastroesophageal reflux disease, and rhinosinusitis. Methods: Adults with asthma (n=65; doctor's diagnosis plus demonstrated response to bronchodilator and/or airways hyperresponsiveness to hypertonic saline) were recruited from the Respiratory and Sleep Medicine Ambulatory Care Service at John Hunter Hospital, NSW, Australia. Questionnaires were administered to assess gastroesophageal reflux disease, rhinosinusitis and asthma control. A sputum induction was performed and sputum was processed for assessment of inflammatory cells, infection, and lipid laden macrophages (Oil Red O). Results: Participants with neutrophilic asthma (n=11, 23%) had a higher frequency of primary care doctor visits for asthma exacerbations and a high prevalence (>70%) of chest infections in the previous 12 months. There was also an increased prevalence of rhinosinusitis (64%) and increased symptoms of gastroesophageal reflux disease compared to those with eosinophilic asthma. Conclusions: The clinical pattern of neutrophilic asthma is different from paucigranulocytic and eosinophilic asthma with evidence of abnormal upper airways responses. Specific and targeted treatment of these airway problems may assist in the control and management of neutrophilic asthma.

DOI 10.12932/AP0322.32.1.2014
Citations Scopus - 1
Co-authors Nicole Ryan, Peter Gibson, Jodie Simpson
2014 Simpson JL, Phipps S, Baines KJ, Oreo KM, Gunawardhana L, Gibson PG, 'Elevated expression of the NLRP3 inflammasome in neutrophilic asthma', European Respiratory Journal, 43 1067-1076 (2014) [C1]

Asthma is a heterogeneous inflammatory airways disorder where interleukin (IL)-1ß is thought to be a key mediator, especially in the neutrophilic subtype of asthma. The generatio... [more]

Asthma is a heterogeneous inflammatory airways disorder where interleukin (IL)-1ß is thought to be a key mediator, especially in the neutrophilic subtype of asthma. The generation of active IL-1ß requires proteolytic cleavage typically mediated through the formation of a caspase-1-containing inflammasome. This study hypothesised that an IL-1ß endotype associated with the nucleotide-binding domain, leucine-rich repeat-containing family protein (NLRP)3/apoptosis-associated speck-like protein containing a caspase-recruitment domain (ASC)/caspase-1 inflammasome is characteristic of patients with the neutrophilic subtype of asthma. Participants with asthma (n=85) and healthy controls (n=27) underwent clinical assessment, spirometry and sputum induction. Sputum was processed for differential cell count, gene expression and protein mediators. NLRP3 and caspase-1 expression was also determined by immunocytochemistry. Sputum macrophages were isolated (n=8) and gene expression of NLRP3 and IL-1ß determined. There was significantly elevated gene expression of NLRP3, caspase-1, caspase-4, caspase-5 and IL-1ß in participants with neutrophilic asthma. Protein levels of IL-1ß were significantly higher in those with neutrophilic asthma and correlated with sputum IL-8 levels. Sputum macrophages, as well as sputum neutrophils in neutrophilic asthma, expressed NLRP3 and caspase-1 protein. NLRP3 inflammasome is upregulated in neutrophilic asthma and may regulate the inflammation process observed in this asthma phenotype through production of IL-1ß. Copyright © ERS 2014.

DOI 10.1183/09031936.00105013
Citations Scopus - 9Web of Science - 9
Co-authors Jodie Simpson, Peter Gibson
2014 Murphy VE, Mattes J, Powell H, Baines KJ, Gibson PG, 'Respiratory viral infections in pregnant women with asthma are associated with wheezing in the first 12 months of life', Pediatric Allergy and Immunology, 25 151-158 (2014) [C1]

Background: There are few studies investigating the relationship between respiratory viral infection in pregnancy and asthma in the offspring, and none among mothers with asthma. ... [more]

Background: There are few studies investigating the relationship between respiratory viral infection in pregnancy and asthma in the offspring, and none among mothers with asthma. Infants of mothers with asthma are more likely to wheeze and have a higher risk of developing asthma than infants of non-asthmatic mothers. Methods: A prospective cohort study of viral infection in pregnancy was conducted between 2007 and 2009, and a subgroup of infants of mothers with asthma was followed up at 6 and 12 months of age. During common colds, nasal and throat swabs were collected from mothers and respiratory viruses detected by polymerase chain reaction. Respiratory health of infants was assessed by parent-completed questionnaire. Results: Twelve-month-old infants whose mothers had confirmed viral infections in pregnancy (n = 26) reported more frequent wheeze (40% had 4-12 wheeze attacks compared with 0%), sleep disturbed by wheeze (1 night per week or more in 60% vs. 11%), beta agonist treatment for wheeze (27% vs. 0%), prolonged colds (2 wk or longer 31% vs. 0%), more eczema (40% vs. 6.3%), and parent-perceived asthma (32% vs. 0%), compared with infants whose mothers had common colds without laboratory-confirmed viral infection (n = 16). Conclusions: This study demonstrates a relationship between maternal respiratory viral infection in pregnancy and wheezing illness in infants of mothers with asthma. Viral infections are the most common cause of asthma exacerbations in pregnancy, and infants of asthmatic mothers are at increased risk of asthma themselves. Further research is needed to elucidate the mechanisms involved. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

DOI 10.1111/pai.12156
Citations Scopus - 2Web of Science - 2
Co-authors Vanessa Murphy, Joerg Mattes, Peter Gibson
2014 Oreo KM, Gibson PG, Simpson JL, Wood LG, Mcdonald VM, Baines KJ, 'Sputum ADAM8 expression is increased in severe asthma and COPD', Clinical and Experimental Allergy, 44 342-352 (2014) [C1]

Background: Severe asthma and chronic obstructive pulmonary disease (COPD) are chronic inflammatory airway diseases in which the mechanisms are not fully understood. A disintegrin... [more]

Background: Severe asthma and chronic obstructive pulmonary disease (COPD) are chronic inflammatory airway diseases in which the mechanisms are not fully understood. A disintegrin and metalloproteinase domain 8 (ADAM8) is an enzyme expressed on most leucocytes and may be important for facilitating leucocyte migration in respiratory disease. Objective: To investigate ADAM8 mRNA and protein expression in asthma and COPD and its relationship between asthma severity and inflammatory phenotypes. Methods: Induced sputum was collected from 113 subjects with asthma (severe n = 31, uncontrolled n = 39 and controlled n = 35), 20 subjects with COPD and 21 healthy controls. Sputum ADAM8 mRNA expression was measured by qPCR, and soluble ADAM8 (sADAM8) protein was measured in the sputum supernatant by validated ELISA. Results: ADAM8 mRNA correlated with ADAM8 protein levels (r = 0.27, P < 0.01). ADAM8 mRNA (P = 0.004) and sADAM8 protein (P = 0.014) levels were significantly higher in both asthma and COPD compared with healthy controls. ADAM8 mRNA (P = 0.035) and sADAM8 protein (P = 0.002) levels were significantly higher in severe asthma compared with controlled asthma. Total inflammatory cell count (P < 0.01) and neutrophils (P < 0.01) were also elevated in severe asthmatic sputum. Although ADAM8 mRNA was significantly higher in eosinophilic and neutrophilic asthma (P < 0.001), sADAM8 did not differ between asthma inflammatory phenotypes. ADAM8 expression positively correlated with sputum total cell count and sputum neutrophils. Conclusions and Clinical Relevance: ADAM8 expression is increased in both severe asthma and COPD and associated with sputum total cell count and neutrophils. ADAM8 may facilitate neutrophil migration to the airways in severe asthma and COPD. © 2013 John Wiley & Sons Ltd.

DOI 10.1111/cea.12223
Citations Scopus - 1Web of Science - 1
Co-authors Vanessa Mcdonald, Lisa Wood, Peter Gibson, Jodie Simpson
2014 Gunawardhana LP, Gibson PG, Simpson JL, Powell H, Baines KJ, 'Activity and expression of histone acetylases and deacetylases in inflammatory phenotypes of asthma', Clinical & Experimental Allergy, 44 47-57 (2014) [C1]
DOI 10.1111/cea.12168
Citations Scopus - 3Web of Science - 2
Co-authors Jodie Simpson, Peter Gibson
2014 Simpson JL, Powell H, Baines KJ, Milne D, Coxson HO, Hansbro PM, Gibson PG, 'The Effect of Azithromycin in Adults with Stable Neutrophilic COPD: A Double Blind Randomised, Placebo Controlled Trial', PLOS ONE, 9 (2014) [C1]
DOI 10.1371/journal.pone.0105609
Citations Scopus - 3Web of Science - 3
Co-authors Jodie Simpson, Philip Hansbro, Peter Gibson
2014 Baines KJ, Simpson JL, Wood LG, Scott RJ, Fibbens NL, Powell H, et al., 'Sputum gene expression signature of 6 biomarkers discriminates asthma inflammatory phenotypes', Journal of Allergy and Clinical Immunology, 133 997-1007 (2014) [C1]

Background Airway inflammation is associated with asthma exacerbation risk, treatment response, and disease mechanisms. Objective This study aimed to identify and validate a sputu... [more]

Background Airway inflammation is associated with asthma exacerbation risk, treatment response, and disease mechanisms. Objective This study aimed to identify and validate a sputum gene expression signature that discriminates asthma inflammatory phenotypes. Methods An asthma phenotype biomarker discovery study generated gene expression profiles from induced sputum of 47 asthmatic patients. A clinical validation study (n = 59 asthmatic patients) confirmed differential expression of key genes. A 6-gene signature was identified and evaluated for reproducibility (n = 30 asthmatic patients and n = 20 control subjects) and prediction of inhaled corticosteroid (ICS) response (n = 71 asthmatic patients). Receiver operating characteristic curves were calculated, and area under the curve (AUC) values were reported. Results From 277 differentially expressed genes between asthma inflammatory phenotypes, we identified 23 genes that showed highly significant differential expression in both the discovery and validation populations. A signature of 6 genes, including Charcot-Leydon crystal protein (CLC); carboxypeptidase A3 (CPA3); deoxyribonuclease I-like 3 (DNASE1L3); IL-1ß (IL1B); alkaline phosphatase, tissue-nonspecific isozyme (ALPL); and chemokine (C-X-C motif) receptor 2 (CXCR2), was reproducible and could significantly (P <.0001) discriminate eosinophilic asthma from other phenotypes, including patients with noneosinophilic asthma (AUC, 89.6%), paucigranulocytic asthma (AUC, 92.6%), or neutrophilic asthma (AUC, 91.4%) and healthy control subjects (AUC, 97.6%), as well as discriminating patients with neutrophilic asthma from those with paucigranulocytic asthma (AUC, 85.7%) and healthy control subjects (AUC, 90.8). The 6-gene signature predicted ICS response (>12% change in FEV1; AUC, 91.5%). ICS treatment reduced the expression of CLC, CPA3, and DNASE1L3 in patients with eosinophilic asthma. Conclusions A sputum gene expression signature of 6 biomarkers reproducibly and significantly discriminates inflammatory phenotypes of asthma and predicts ICS treatment response. This signature has the potential to become a useful diagnostic tool to assist in the clinical diagnosis and management of asthma. © 2013 American Academy of Allergy, Asthma & Immunology.

DOI 10.1016/j.jaci.2013.12.1091
Citations Scopus - 11Web of Science - 13
Co-authors Jodie Simpson, Lisa Wood, Peter Gibson, Rodney Scott
2014 Gunawardhana LP, Baines KJ, Mattes J, Murphy VE, Simpson JL, Gibson PG, 'Differential DNA methylation profiles of infants exposed to maternal asthma during pregnancy', Pediatric Pulmonology, 49 852-862 (2014) [C1]

Background Asthma is a complex disease that involves both genetic factors and environmental exposures. Aberrant epigenetic modifications, such as DNA methylation, may be important... [more]

Background Asthma is a complex disease that involves both genetic factors and environmental exposures. Aberrant epigenetic modifications, such as DNA methylation, may be important in asthma development. Fetal exposure to maternal asthma during critical periods of in utero development may lead to epigenetic alterations that predispose infants to a greater risk of developing asthma themselves. We investigated alterations in the DNA methylation profile of peripheral blood from infants exposed to maternal asthma during pregnancy. Methods Peripheral blood was collected from 12-month-old infants born to women with (n = 25) and without (n = 15) doctor diagnosed asthma during pregnancy. Genomic DNA was extracted, bisulfite converted, and hybridized to Infinium Methylation 27 arrays (Illumina), containing over27,000 CpGs from 14,495 genes. CpG loci in only autosomal genes were classified as differentially methylated at the 99% level (P < 0.01, |DiffScore| > 22 and delta beta >0.06). Results There were 70 CpG loci, corresponding to 67 genes that were significantly differentially methylated. Twelve CpG loci (11 genes) showed greater than 10% comparative difference in DNA methylation, including hyper-methylated loci of FAM181A, MRI1, PIWIL1, CHFR, DEFA1, MRPL28, AURKA, and hypo-methylated loci of NALP1L5, MAP8KIP3, ACAT2, and PM20D1 in maternal asthma. Methylation of MAPK8IP3 was significantly negatively correlated with maternal blood eosinophils (r = -0.38; P = 0.022), maternal eNO (r = -0.44; P = 0.005), and maternal serum total IgE (r = -0.39, P = 0.015). Methylation of AURKA negatively correlated with maternal hemoglobin (r = -0.43; P = 0.008), infants height (r = -0.51; P < 0.001) and weight (r = -0.36; P = 0.021). Methylation of PM20D1 was lower in infants born to mothers with asthma on inhaled corticosteroid treatment. Methylation of PM20D1 was lower and MRI1 was higher in infants born to atopic mothers without asthma. Conclusions In an Australian study population, exposure to maternal asthma during pregnancy is associated with differential methylation profiles of infants' peripheral blood DNA, which may act as risk factors for future asthma development. © 2013 Wiley Periodicals, Inc.

DOI 10.1002/ppul.22930
Citations Scopus - 3Web of Science - 2
Co-authors Peter Gibson, Vanessa Murphy, Jodie Simpson, Joerg Mattes
2014 Gunawardhana LP, Gibson PG, Simpson JL, Benton MC, Lea RA, Baines KJ, 'Characteristic DNA methylation profiles in peripheral blood monocytes are associated with inflammatory phenotypes of asthma.', Epigenetics, 9 1302-1316 (2014) [C1]
DOI 10.4161/epi.33066
Citations Scopus - 2Web of Science - 4
Co-authors Peter Gibson, Jodie Simpson
2014 Baines KJ, Pavord ID, Gibson PG, 'The role of biomarkers in the management of airways disease.', Int J Tuberc Lung Dis, 18 1264-1268 (2014) [C1]
DOI 10.5588/ijtld.14.0226
Citations Scopus - 3Web of Science - 2
Co-authors Peter Gibson
2013 Kaiko GE, Loh Z, Spann K, Lynch JP, Lalwani A, Zheng Z, et al., 'Toll-like receptor 7 gene deficiency and early-life Pneumovirus infection interact to predispose toward the development of asthma-like pathology in mice', JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 131 1331-U132 (2013) [C1]
DOI 10.1016/j.jaci.2013.02.041
Citations Scopus - 20Web of Science - 18
Co-authors Jodie Simpson, Paul Foster
2013 Simpson JL, McDonald VM, Baines KJ, Oreo KM, Wang F, Hansbro PM, Gibson PG, 'Influence of Age, Past Smoking, and Disease Severity on TLR2, Neutrophilic Inflammation, and MMP-9 Levels in COPD', MEDIATORS OF INFLAMMATION, (2013) [C1]
DOI 10.1155/2013/462934
Citations Scopus - 6Web of Science - 6
Co-authors Philip Hansbro, Jodie Simpson, Vanessa Mcdonald, Peter Gibson
2013 Baines KJ, Hsu AC-Y, Tooze M, Gunawardhana LP, Gibson PG, Wark PAB, 'Novel immune genes associated with excessive inflammatory and antiviral responses to rhinovirus in COPD', RESPIRATORY RESEARCH, 14 (2013) [C1]
DOI 10.1186/1465-9921-14-15
Citations Scopus - 7Web of Science - 9
Co-authors Alan Hsu, Peter Gibson, Peter Wark
2013 Fu J-J, Baines KJ, Wood LG, Gibson PG, 'Systemic Inflammation Is Associated with Differential Gene Expression and Airway Neutrophilia in Asthma', OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY, 17 187-199 (2013) [C1]
DOI 10.1089/omi.2012.0104
Citations Scopus - 11Web of Science - 9
Co-authors Lisa Wood, Peter Gibson
2012 Wood LG, Baines KJ, Fu J, Scott HA, Gibson PG, 'The neutrophilic inflammatory phenotype is associated with systemic inflammation in asthma', Chest, 142 86-93 (2012) [C1]
Citations Scopus - 47Web of Science - 44
Co-authors Hayley Scott, Lisa Wood, Peter Gibson
2011 Baines KJ, Simpson JL, Gibson PG, 'Innate immune responses are increased in chronic obstructive pulmonary disease', PLoS ONE, 36 e18426 (2011) [C1]
DOI 10.1371/journal.pone.0018426
Citations Scopus - 28Web of Science - 19
Co-authors Peter Gibson, Jodie Simpson
2011 Baines KJ, Simpson JL, Wood LG, Scott R, Gibson PG, 'Systemic upregulation of neutrophil a-defensins and serine proteases in neutrophilic asthma', Thorax, 66 942-947 (2011) [C1]
Citations Scopus - 15Web of Science - 16
Co-authors Peter Gibson, Rodney Scott, Jodie Simpson, Lisa Wood
2011 Baines KJ, Simpson JL, Wood LG, Scott R, Gibson PG, 'Transcriptional phenotypes of asthma defined by gene expression profiling of induced sputum samples', Journal of Allergy and Clinical Immunology, 127 153.e9-160.e9 (2011) [C1]
DOI 10.1016/j.jaci.2010.10.024
Citations Scopus - 67Web of Science - 58
Co-authors Lisa Wood, Peter Gibson, Rodney Scott, Jodie Simpson
2011 Wang F, He XY, Baines KJ, Gunawardhana LP, Simpson JL, Li F, Gibson PG, 'Different inflammatory phenotypes in adults and children with acute asthma', European Respiratory Journal, 38 567-574 (2011) [C1]
DOI 10.1183/09031936.00170110
Citations Scopus - 29Web of Science - 25
Co-authors Peter Gibson, Jodie Simpson
2010 Li J, Wang W, Baines KJ, Bowden NA, Hansbro PM, Gibson PG, et al., 'IL-27/IFN-y induce MyD88-dependent steroid-resistant airway hyperresponsiveness by inhibiting glucocorticoid signaling in macrophages', Journal of Immunology, 185 4401-4409 (2010) [C1]
DOI 10.4049/jimmunol.1001039
Citations Scopus - 35Web of Science - 32
Co-authors Philip Hansbro, Peter Gibson, Paul Foster, Ming Yang, Nikola Bowden
2010 Baines KJ, Simpson JL, Bowden NA, Scott R, Gibson PG, 'Differential gene expression and cytokine production from neutrophils in asthma phenotypes', European Respiratory Journal, 35 522-531 (2010) [C1]
DOI 10.1183/09031936.00027409
Citations Scopus - 32Web of Science - 24
Co-authors Nikola Bowden, Rodney Scott, Peter Gibson, Jodie Simpson
2009 Baines KJ, Wood LG, Gibson PG, 'The nutrigenomics of asthma: Molecular mechanisms of airway neutrophilia following dietary antioxidant withdrawal', OMICS: A Journal of Integrative Biology, 13 355-365 (2009) [C1]
DOI 10.1089/omi.2009.0042
Citations Scopus - 13Web of Science - 11
Co-authors Peter Gibson, Lisa Wood
2009 Baines KJ, Simpson JL, Scott R, Gibson PG, 'Immune responses of airway neutrophils are impaired in asthma', Experimental Lung Research, 35 554-569 (2009) [C1]
DOI 10.1080/01902140902777490
Citations Scopus - 14Web of Science - 15
Co-authors Rodney Scott, Peter Gibson, Jodie Simpson
2009 Simpson JL, Baines KJ, Boyle MJ, Scott R, Gibson PG, 'Oncostatin M (OSM) is increased in asthma with incompletely reversible airflow obstruction', Experimental Lung Research, 35 781-794 (2009) [C1]
DOI 10.3109/01902140902906412
Citations Scopus - 10Web of Science - 11
Co-authors Rodney Scott, Peter Gibson, Jodie Simpson
Show 31 more journal articles

Conference (65 outputs)

Year Citation Altmetrics Link
2015 McDonald V, Wark P, Baines K, Gibson P, 'The multidimensional components of severe asthma', Am J Resp Crit Care Med (2015)
2015 Tang F, Gibson P, Foxley G, Burgess J, Baines K, Oliver B, 'Neutrophils from people with uncontrolled asthma have a deficient CXCL8 response to bacteria but not to viruses', Am J Resp Crit Care Med (2015)
2015 Baines K, Wright T, Simpson J, McDonald V, Wood L, Gibson P, 'Accumulation of neutrophil extracellular traps is associated with inflammation in neutrophilic asthma and COPD', Am J Resp Crit Care Med (2015)
2015 McDonald V, Wark P, Baines K, Gibson P, 'The multidimensional components of severe asthma', Respirology (2015)
2015 Tang F, Gibson P, Foxley G, Burgess J, Baines K, Oliver B, 'Deficient CXCL8 response to bacteria but not to viruses in neutrophils from people with uncontrolled asthma', Respirology (2015)
2015 Tang F, Hansbro P, Burgess J, Baines K, Oliver B, 'Neutrophils display immunoregulatory roles in rhinovirus infections', Respirology (2015)
2015 Baines K, Wright T, Simpson J, McDonald V, Wood L, Gibson P, 'Excessive neutrophil extracellular traps are associated with inflammation in chronic airway disease', Respirology (2015)
2015 Upham J, Chen A, Carroll M, Petsky H, Pizzutto S, Yerkovich S, et al., 'Immune responses to nontypeable haemophilus influenza in protracted bacterial bronchitis.', Respirology (2015)
2015 Erriah M, Gao P, Baines K, Gibson P, Simpson J, 'Sputum galectin-3 expression is associated with eosinophils in COPD', Respirology (2015)
2015 Tang F, Hansbro P, Burgess J, Baines K, Oliver B, 'A novel immunoregulatory role of neutrophils in viral infections' (2015)
2014 Wright T, Gibson P, Simpson J, Mcdonald V, Wood L, Baines K, 'ALARMINS IN ASTHMA AND COPD: RELATIONSHIPS TO INFLAMMATORY PHENOTYPES AND DISEASE SEVERITY', RESPIROLOGY (2014) [E3]
Co-authors Lisa Wood, Peter Gibson, Jodie Simpson, Vanessa Mcdonald
2014 Baines K, Simpson J, Wood L, Scott R, Fibbens N, Powell H, et al., 'SPUTUM GENE EXPRESSION OF SIX MARKERS IDENTIFIES ASTHMA INFLAMMATORY PHENOTYPE AND CORTICOSTEROID RESPONSE', RESPIROLOGY (2014) [E3]
Co-authors Lisa Wood, Rodney Scott, Jodie Simpson
2014 Baines K, Upham J, Yerkovich S, Chang A, Marchant J, Carroll M, et al., 'INTERLEUKIN-1B IS RELATED TO CLINICAL OUTCOMES IN PROTRACTED BACTERIAL BRONCHITIS', RESPIROLOGY (2014) [E3]
Co-authors Jodie Simpson, Peter Gibson
2014 Simpson J, Gao P, Baines K, Yang I, Reynolds P, Hodge S, et al., 'GALECTIN 3 AND GALECTIN 3 BINDING PROTEIN IN ASTHMA INFLAMMATORY SUBTYPES', RESPIROLOGY (2014) [E3]
Co-authors Jodie Simpson, Peter Gibson
2014 Tang F, Van Ly D, Reading P, Spann K, Hartl D, Burgess JK, et al., 'Neutrophils Respond To Viral Surrogates And Respiratory Viruses', Am J Resp Crit Care Med (2014)
2014 Fu JJ, McDonald VM, Baines KJ, Mao B, Gibson PG, 'Airway IL-1 Pathway Activation And Systemic Inflammation Predict Future Exacerbation Risk In Asthma And COPD', Am J Resp Crit Care Med (2014)
2014 Baines K, Backer V, Gibson P, Powell H, Porsbjerg C, 'Systemic inflammation, diet, and place of residence modify lung function in Greenland Inuit.', Eur Resp J (2014)
2014 Sverrild A, Baines K, Backer V, Gibson P, Porsbjerg C, 'Increased IL-33 expression is related to high levels of TLR-2 and -4 in steroid-free subjects with asthma', Eur Resp J (2014)
2014 Porsbjerg C, Baines K, Sverrild A, Backer V, Gibson P, 'Eosinophilic airway inflammation is associated with increased TLR2 and TLR4 expression in adult asthmatics.', Eur Resp J (2014)
2014 Tang F, Van Ly D, Reading P, Baines KJ, Spann K, Burgess J, et al., 'Viral surrogates and respiratory viruses differentially activate neutrophils', Respirology (2014)
2013 Gunawardhana LP, Baines KJ, Mattes J, Murphy VE, Simpson JL, Gibson PG, 'EPIGENETIC ALTERATIONS IN INFANTS ASSOCIATED WITH MATERNAL ASTHMA DURING PREGNANCY', RESPIROLOGY (2013) [E3]
Co-authors Joerg Mattes, Jodie Simpson, Vanessa Murphy, Peter Gibson
2013 Simpson JL, Baines KJ, Ryan NM, Gibson PG, 'NEUTROPHILIC ASTHMA IS CHARACTERIZED BY INCREASED GERD AND RHINOSINUSITIS WITH SLEEP DISTURBANCE', RESPIROLOGY (2013) [E3]
Co-authors Peter Gibson, Jodie Simpson, Nicole Ryan
2013 Baines KJ, Simpson JL, Mcdonald VM, Hsu AC, Gibson PG, 'DIFFERENTIAL AIRWAY GENE EXPRESSION IN COPD', RESPIROLOGY (2013) [E3]
Co-authors Alan Hsu, Peter Gibson, Vanessa Mcdonald, Jodie Simpson
2013 Wang G, Baines KJ, Fu JJ, Gibson PG, 'MAST CELL-BASED PHENOTYPES OF ASTHMA IN INDUCED SPUTUM SAMPLES', RESPIROLOGY (2013) [E3]
Co-authors Peter Gibson
2013 Baines KJ, Simpson JL, Wood LG, Scott RJ, Fibbens NL, Powell H, et al., 'Sputum gene expression of six markers identifies asthma inflammatory phenotype and corticosteroid response.', Australasian Genomic Technologies Association Annual Scientific Meeting, Gold Coast, QLD (2013)
2013 Baines KJ, Upham JW, Yerkovich ST, Chang AB, Marchant J, Carroll M, et al., 'Interleukin-1ß is related to clinical outcomes in protracted bacterial bronchitis', Australasian Society for Immunology, Wellington, NZ (2013)
2012 Simpson JL, Phipps S, Baines KJ, Oreo KM, Gibson PG, 'NALP3 INFLAMMASOME ACTIVATION IN NEUTROPHILIC ASTHMA', RESPIROLOGY (2012) [E3]
Co-authors Jodie Simpson, Peter Gibson
2012 Simpson JL, Phipps S, Baines KJ, Oreo K, Gibson PG, 'NALP3 inflammasome activation in neutrophilic asthma', Respirology, Canberra, ACT (2012) [E3]
Co-authors Peter Gibson, Jodie Simpson
2012 Baines KJ, Simpson JL, Wood LG, Scott RJ, Gibson PG, 'Sputum gene expression of mast cell specific proteases are increased in eosinophilic asthma', Respirology, Canberra, ACT (2012) [E3]
Co-authors Rodney Scott, Jodie Simpson, Peter Gibson, Lisa Wood
2012 Baines KJ, Simpson JL, Wood LG, Scott RJ, Gibson PG, 'Induced sputum differential gene expression implicates increased p38 signalling activity in severe asthma', Respirology, Canberra, ACT (2012) [E3]
Co-authors Rodney Scott, Jodie Simpson, Peter Gibson, Lisa Wood
2011 Baines KJ, Simpson JL, Scott R, Wood LG, Gibson PG, 'Systemic upregulation of neutrophil a-defensins and serine proteases in neutrophilic asthma', European Respiratory Society Annual Congress 2011 Abstracts, Amsterdam (2011) [E3]
Co-authors Rodney Scott, Jodie Simpson, Peter Gibson, Lisa Wood
2011 Baines KJ, Simpson JL, Scott R, Wood LG, Gibson PG, 'Sputum gene expression of mast cell tryptase and carboxypeptidase A3 are increased in eosinophilic asthma', European Respiratory Society Annual Congress 2011 Abstracts, Amsterdam (2011) [E3]
Co-authors Lisa Wood, Peter Gibson, Jodie Simpson, Rodney Scott
2011 Baines KJ, Simpson JL, Scott R, Wood LG, Gibson PG, 'Induced sputum differential gene expression implicates increased p38 signalling activity in severe asthma', European Respiratory Society Annual Congress 2011 Abstracts, Amsterdam (2011) [E3]
Co-authors Lisa Wood, Jodie Simpson, Peter Gibson, Rodney Scott
2011 Baines KJ, Simpson JL, Scott RJ, Wood LG, Gibson PG, 'Analysis of systemic gene expression according to inflammatory phenotype of asthma.', Respirology (2011)
2011 Oliver BG, Tang FS, Van Ly D, Burgess JK, Black JL, Baines KJ, 'Imiquimod, poly I:c and rhinovirus induce interleukin (iL)-6 and IL-8 release from polymorphonuclear cells and peripheral blood mononuclear cells: Effect of dexamethasone', American Journal of Respiratory and Critical Care Medicine, Denver, CO (2011) [E3]
2011 Baines KJ, Simpson JL, Scott R, Wood LG, Gibson PG, 'Analysis of systemic gene expression according to inflammatory phenotype of asthma', Respirology, Perth, WA (2011) [E3]
Co-authors Jodie Simpson, Rodney Scott, Lisa Wood, Peter Gibson
2011 Baines KJ, Tooze MK, Wark PA, 'Rhinovirus infected airway epithelial cells have an increased pro-inflammatory response in COPD', Respirology, Perth, WA (2011) [E3]
Co-authors Peter Wark
2011 Gunawardhana LP, Baines KJ, Simpson JL, Mattes J, Murphy VE, Gibson PG, 'Maternal asthma is associated with alterations in DNA methylation profile of peripheral blood of infants', Respirology, Perth, WA (2011) [E3]
Co-authors Jodie Simpson, Joerg Mattes, Vanessa Murphy, Peter Gibson
2011 Oreo K, Baines KJ, Gibson PG, Hansbro PM, 'Pro-inflammatory cytokine production is impaired in response to TLR2 activation in healthy ageing and COPD', Respirology, Perth, WA (2011) [E3]
Co-authors Philip Hansbro, Peter Gibson
2011 Wang F, Xy HA, Baines KJ, Gunawardhana LP, Simpson JL, Ki F, Gibson PG, 'Is chalamydophyla a pneumoniae infection related to non-eosinophilic asthma?', Respirology, Perth, WA (2011) [E3]
Co-authors Jodie Simpson, Peter Gibson
2011 Fu J, Baines KJ, Wood LG, Scott HA, Gibson PG, 'Low-grade systemic inflammation is associated with airway neutrophilia in asthma', Respirology, Shanghai (2011) [E3]
Co-authors Hayley Scott, Lisa Wood, Peter Gibson
2011 Fu J, Baines KJ, Gibson PG, Scott HA, Wood LG, 'Systemic inflammation mediates airway neutrophilia via the regulation of IL-8 receptor mRNA expression', Respirology, Shanghai (2011) [E3]
Co-authors Peter Gibson, Lisa Wood, Hayley Scott
2010 Baines KJ, Simpson JL, Scott R, Wood LG, Gibson PG, 'Molecular phenotypes of asthma defined by gene expression profiling', American Journal of Respiratory and Critical Care Medicine, New Orleans, LO (2010) [E3]
Co-authors Rodney Scott, Jodie Simpson, Peter Gibson, Lisa Wood
2010 Baines KJ, Simpson JL, Scott R, Wood LG, Gibson PG, 'Analysis of systemic gene expression according to inflammatory phenotype of asthma', Biomarker Discovery Conference, Shoal Bay, NSW (2010) [E3]
Co-authors Rodney Scott, Jodie Simpson, Lisa Wood, Peter Gibson
2010 Gunawardhana LG, Baines KJ, Simpson JL, Mattes J, Murphy VE, Gibson PG, (Oral) BDCD2010, 'Maternal asthma is associated with alterations in DNA methylation profile of peripheral blood of infants.', Biomarker Discovery Conference, Shoal Bay, NSW (2010)
2010 Baines KJ, Simpson JL, Scott RJ, Wood LG, Gibson PG, 'Molecular profiling of asthma defined by gene expression', Respirology, Brisbane, QLD (2010) [E3]
Co-authors Jodie Simpson, Lisa Wood, Peter Gibson
2010 Baines KJ, Simpson JL, Scott R, Wood LG, Gibson PG, 'Molecular phenotypes of asthma defined by gene expression profiling', Respirology, Brisbane, QLD (2010) [E3]
Co-authors Lisa Wood, Peter Gibson, Rodney Scott, Jodie Simpson
2009 Baines KJ, Simpson JL, Scott R, Wood LG, Gibson PG, 'Genome wide gene expression of induced sputum in non-eosinophilic asthma', AMATA 2009, Katoomba, NSW (2009) [E3]
Co-authors Lisa Wood, Jodie Simpson, Rodney Scott, Peter Gibson
2009 Bowden NA, Ashton KA, Stibbard GJ, Cox MB, Baines KJ, Scott R, 'Predicting xeroderma pigmentosum complementation group by gene expression profiling', AMATA 2009, Katoomba, NSW (2009) [E3]
Co-authors Rodney Scott, Nikola Bowden, Katie Ashton
2009 Baines KJ, Grissell TV, Gibson PG, Wark PA, 'Molecular mechanisms of rhinovirus infection of primary bronchial epithelial cells', Respirology, Darwin, NT (2009) [E3]
DOI 10.1111/j.1440-1843.2009.01503_1.x
Co-authors Peter Gibson, Peter Wark
2009 Baines KJ, Wood LG, Gibson PG, 'Molecular mechanisms of airway neutrophilia following a low antioxidant diet', Respirology, Darwin, NT (2009) [E3]
DOI 10.1111/j.1440-1843.2009.01503_1.x
Co-authors Peter Gibson, Lisa Wood
2009 Oreo K, Baines KJ, Gibson PG, Hansbro PM, Simpson JL, 'Toll-like receptor agonists stimulate cytokine release from blood but not airway cells', Respirology, Darwin, NT (2009) [E3]
DOI 10.1111/j.1440-1843.2009.01503_1.x
Co-authors Philip Hansbro, Jodie Simpson, Peter Gibson
2008 Baines KJ, Simpson JL, Scott R, Gibson PG, 'Ageing alters airway and circulating neutrophil function', Respirology, Melbourne, VIC (2008) [E3]
DOI 10.1111/j.1440-1843.2008.01252.x
Co-authors Jodie Simpson, Rodney Scott, Peter Gibson
2008 Baines KJ, Simpson JL, Scott R, Gibson PG, 'Innate immune responses of airway neutrophils are impaired in neutrophilic asthma', Respirology, Melbourne, VIC (2008) [E3]
DOI 10.1111/j.1440-1843.2008.01252.x
Co-authors Peter Gibson, Jodie Simpson, Rodney Scott
2008 Bowden NA, Baines KJ, Cox MB, Scott R, 'Altered gene expression in nucleotide excision repair deficient fibroblasts after UV-light exposure', AACR Meeting Abstracts, San Diego, CA (2008) [E3]
Co-authors Nikola Bowden, Rodney Scott
2008 Bowden NA, Baines KJ, Cox MB, Scott R, 'Response to uv-light exposure in fibroblasts with differential nucleotide excision repair capacity', ASMR XVII NSW Scientific Meeting: Programme and Abstracts, Sydney, NSW (2008) [E3]
Co-authors Nikola Bowden, Rodney Scott
2008 Bowden NA, Ashton KA, Baines KJ, Cox MB, Scott R, 'Altered gene expression after UV-light induced DNA damage', Conference on Translational Cancer Research: Abstracts, Newcastle, NSW (2008) [E3]
Co-authors Nikola Bowden, Katie Ashton, Rodney Scott
2008 Baines KJ, Simpson JL, Scott RJ, Gibson PG, 'Innate Immune Responses of Neutrophils are Impaired in Neutrophilic Asthma', Am J Resp Crit Care Med (2008)
2008 Baines KJ, Simpson JL, Scott RJ, Gibson PG, 'Ageing Alters Airway and Circulating Neutrophil Function.', Am J Resp Crit Care Med (2008)
2008 Baines KJ, Simpson JL, Scott RJ, Gibson PG, 'Ageing Alters Airway and Circulating Neutrophil Function', Respirology (2008)
2007 Baines KJ, Bowden NA, Scott R, Simpson JL, Gibson PG, 'Molecular analysis of neutrophils in asthma subtypes', Respirology (TSANZ Abstracts-Posters), Auckland (2007) [E3]
DOI 10.1111/j.1440-1843.2007.001050.x
Co-authors Peter Gibson, Jodie Simpson, Rodney Scott, Nikola Bowden
2007 Baines KJ, Bowden NA, Scott RJ, Simpson JL, Gibson PG, 'Molecular Analysis of Neutrophils in Asthma Subtypes', Am J Resp Crit Care Med (2007)
2007 Gibson PG, Baines KJ, Simpson JL, Scott RJ, 'Gene Expression Profiling Identifies Neutrophilic and Eosinophilic Asthma as Distinct Subtypes.', Eur Resp J (2007)
2006 Baines KJ, Simpson JL, Scott R, Bell NV, Boyle MJ, Gibson PG, 'Enhanced IL-8 release from neutrophils in non-eosinophilic asthma', Respirology, Canberra (2006) [E3]
Co-authors Peter Gibson, Rodney Scott, Jodie Simpson
2005 Baines KJ, Bell NV, Simpson JL, Scott RJ, Boyle MJ, Gibson PG, 'Enhanced IL-8 Release from Neutrophils in Non-Eosinophilic Asthma', Inflammation Research (2005)
Show 62 more conferences
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Grants and Funding

Summary

Number of grants 33
Total funding $2,141,631

Click on a grant title below to expand the full details for that specific grant.


20153 grants / $305,222

Targeting neutrophil extracellular traps as a novel therapeutic option in COPD$160,000

Funding body: Lung Foundation Australia

Funding body Lung Foundation Australia
Project Team Doctor Katie Baines
Scheme Boehringer Ingelheim Chronic Obstructive Pulmonary Disease Research Fellowship
Role Lead
Funding Start 2015
Funding Finish 2015
GNo G1500407
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Improving diet quality to reduce risk of asthma attacks in children$120,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Associate Professor Lisa Wood, Professor Joerg Mattes, Conjoint Professor Peter Wark, Doctor Katie Baines, Miss Megan Jensen
Scheme Project Grant
Role Investigator
Funding Start 2015
Funding Finish 2015
GNo G1500957
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Targeting neutrophil extracellular traps as a novel therapeutic option in COPD$25,222

Funding body: John Hunter Hospital Charitable Trust Fund

Funding body John Hunter Hospital Charitable Trust Fund
Project Team Doctor Katie Baines, Conjoint Professor Peter Gibson
Scheme Research Grant
Role Lead
Funding Start 2015
Funding Finish 2015
GNo G1500570
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

20146 grants / $269,397

Greenland Study$140,000

Funding body: Bispebjerg Hospital

Funding body Bispebjerg Hospital
Project Team Conjoint Professor Peter Gibson, Doctor Katie Baines, Professor Vibeke Backer
Scheme International Collaboration
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1400539
Type Of Funding International - Non Competitive
Category 3IFB
UON Y

Identifying biomarkers that predict severe asthma exacerbations during pregnancy$60,000

Funding body: Thoracic Society of Australia and New Zealand

Funding body Thoracic Society of Australia and New Zealand
Project Team Doctor Katie Baines
Scheme TSANZ/National Asthma Council Australia - Asthma and Airways Career Development Fellowship
Role Lead
Funding Start 2014
Funding Finish 2014
GNo G1400730
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Identifying biomarkers that predict severe asthma exacerbations during pregnancy$27,512

Funding body: John Hunter Hospital Charitable Trust Fund

Funding body John Hunter Hospital Charitable Trust Fund
Project Team Doctor Katie Baines, Emeritus Professor Michael Hensley
Scheme Research Grant
Role Lead
Funding Start 2014
Funding Finish 2014
GNo G1400631
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

The role of comorbidities and inflammation in Chronic Obstructive Pulmonary Disease (COPD)$20,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Mrs Netsanet Negewo, Associate Professor Vanessa McDonald, Conjoint Professor Peter Gibson, Doctor Katie Baines
Scheme Postgraduate Research Scholarship
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1401393
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Predicting who is at risk of worsening lung disease in Cystic Fibrosis$20,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Conjoint Professor Peter Wark, Doctor Katie Baines, Associate Professor Vanessa McDonald, Conjoint Professor Peter Gibson, Associate Professor Scott Bell, Dr David Reid
Scheme Project Grant
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1401410
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Thoracic Society of Australia and New Zealand, Adelaide Australia, 4-9 April 2014$1,885

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Doctor Katie Baines
Scheme Travel Grant
Role Lead
Funding Start 2014
Funding Finish 2014
GNo G1400186
Type Of Funding Internal
Category INTE
UON Y

20135 grants / $572,508

Gene Expression Biomarkers Predict Severe Asthma Inflammatory Phenotype, Activation Mechanisms and Treatment Response$449,307

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Doctor Katie Baines, Conjoint Professor Peter Gibson, Associate Professor Jodie Simpson
Scheme Project Grant
Role Lead
Funding Start 2013
Funding Finish 2013
GNo G1200188
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Protracted bacterial bronchitis: long term outcomes, systemic and airway predictors of recurrence$76,526

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Anne Chang, Professor John Upham, Conjoint Professor Peter Gibson, Dr Stephanie Yerkovich, Doctor Katie Baines, Dr Sandra Hodge, Mrs Susan Pizzuto, Associate Professor Ian Masters, Dr Helen Buntain
Scheme Project Grant
Role Investigator
Funding Start 2013
Funding Finish 2013
GNo G1200534
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

BD FACSCanto II Violet Laser (405nm) upgrade including Trigon and 2 photomultiplier tubes (PMTs)$25,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Peter Wark, Doctor Alan Hsu, Doctor Katie Baines, Associate Professor Jodie Simpson, Conjoint Professor Peter Gibson, Ms Hayley See
Scheme Equipment Grant
Role Investigator
Funding Start 2013
Funding Finish 2013
GNo G1201180
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

DP73 Digital colour and monochrome camera + cellSens software + Xcite120 fluorescence lamp illuminator$20,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Laureate Professor Paul Foster, Doctor Alan Hsu, Professor Phil Hansbro, Professor Joerg Mattes, Doctor Katie Baines, Associate Professor Jodie Simpson, Professor Rakesh Kumar, Doctor Nicole Hansbro, Doctor Steven Maltby, Doctor Ming Yang, Doctor Gerard Kaiko, Doctor Jay Horvat, Doctor Simon Keely, Doctor Andrew Jarnicki, Doctor Michael Fricker
Scheme Equipment Grant
Role Investigator
Funding Start 2013
Funding Finish 2013
GNo G1201186
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

Thoracic Society of Australia and New Zealand$1,675

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Doctor Katie Baines
Scheme Travel Grant
Role Lead
Funding Start 2013
Funding Finish 2013
GNo G1300405
Type Of Funding Internal
Category INTE
UON Y

20125 grants / $435,832

2011 Research Fellowship - PRCARD$333,302

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Doctor Katie Baines
Scheme Research Fellowship
Role Lead
Funding Start 2012
Funding Finish 2012
GNo G1200356
Type Of Funding Internal
Category INTE
UON Y

Phenotype based management of severe persistent asthma$34,454

Funding body: John Hunter Hospital Charitable Trust Fund

Funding body John Hunter Hospital Charitable Trust Fund
Project Team Associate Professor Vanessa McDonald, Doctor Katie Baines, Conjoint Professor Peter Gibson
Scheme Research Grant
Role Investigator
Funding Start 2012
Funding Finish 2012
GNo G1200211
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Body plethysmograph respiratory function system$33,076

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Peter Gibson, Conjoint Professor Peter Wark, Associate Professor Lisa Wood, Associate Professor Jodie Simpson, Doctor Katie Baines, Doctor Vanessa Murphy, Doctor Jeffrey Pretto, Emeritus Professor Michael Hensley, Ms Jenny Mackney
Scheme Equipment Grant
Role Investigator
Funding Start 2012
Funding Finish 2012
GNo G1100973
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

Phenotype based management of severe persistent asthma$20,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Associate Professor Vanessa McDonald, Doctor Katie Baines, Conjoint Professor Peter Gibson
Scheme Research Grant
Role Investigator
Funding Start 2012
Funding Finish 2012
GNo G1101169
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Gene expression markers, mechanisms and steroid response of neutrophilic asthma$15,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Doctor Katie Baines
Scheme Fellowship Grant
Role Lead
Funding Start 2012
Funding Finish 2012
GNo G1200082
Type Of Funding Internal
Category INTE
UON Y

20117 grants / $92,989

Transcriptional Phenotyping of COPD and the relationship between neutrophilic airway inflammation, airway infection and activation of proinflammatory pathways$24,000

Funding body: John Hunter Hospital Charitable Trust Fund

Funding body John Hunter Hospital Charitable Trust Fund
Project Team Doctor Katie Baines, Conjoint Professor Peter Gibson, Associate Professor Jodie Simpson
Scheme Research Grant
Role Lead
Funding Start 2011
Funding Finish 2011
GNo G1100635
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Identification of a specific biomarker signature that identifies asthma phenotype $23,700

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Katie Baines, Associate Professor Jodie Simpson, Conjoint Professor Peter Gibson
Scheme Project Grant
Role Lead
Funding Start 2011
Funding Finish 2011
GNo G1001054
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Transcriptional Phenotyping of COPD and the relationship between neutrophilic airway inflammation, airway infection and activation of proinflammatory pathways$20,000

Funding body: Lung Foundation Australia

Funding body Lung Foundation Australia
Project Team Doctor Katie Baines
Scheme Grant-In-Aid for New and Emerging Researchers
Role Lead
Funding Start 2011
Funding Finish 2011
GNo G1000976
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Epigenetic changes in infants associated with maternal asthma during pregnancy$10,000

Funding body: Thoracic Society of Australia and New Zealand

Funding body Thoracic Society of Australia and New Zealand
Project Team Doctor Katie Baines
Scheme Grant-in-aid (supported by Merck Sharp & Dohme)
Role Lead
Funding Start 2011
Funding Finish 2011
GNo G1000991
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Lung Function (Spirometry) testing and sputum induction equipment - establishing 3 new clinical workstations. Medgraphics CPFS/d USB spirometer with breezesuite software (x3). Laptop computer (x3). Ul$10,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Peter Gibson, Associate Professor Jodie Simpson, Associate Professor Lisa Wood, Doctor Katie Baines, Conjoint Professor Peter Wark, Doctor Vanessa Murphy
Scheme Equipment Grant
Role Investigator
Funding Start 2011
Funding Finish 2011
GNo G1100038
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

PULSE Education Prize$4,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Katie Baines
Scheme PULSE Education Prize
Role Lead
Funding Start 2011
Funding Finish 2011
GNo G1100342
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Thoracic Society of Australia and New Zealand, Perth Convention and Exhibition Centre, 2 - 6 April 2011$1,289

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Doctor Katie Baines
Scheme Travel Grant
Role Lead
Funding Start 2011
Funding Finish 2011
GNo G1100297
Type Of Funding Internal
Category INTE
UON Y

20101 grants / $34,000

Real time PCR machine (Mastercycler ep realplex2 from Epprndorf) $34,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Associate Professor Jodie Simpson, Conjoint Professor Peter Gibson, Conjoint Professor Peter Wark, Associate Professor Lisa Wood, Doctor Vanessa Murphy, Doctor Robert Scott, Doctor Katie Baines
Scheme Equipment Grant
Role Investigator
Funding Start 2010
Funding Finish 2010
GNo G1000056
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

20091 grants / $63,354

Epigenetic regulation of airways inflammation in non-eosinophilic asthma$63,354

Funding body: Asthma Foundation of New South Wales

Funding body Asthma Foundation of New South Wales
Project Team Conjoint Professor Peter Gibson, Doctor Katie Baines, Associate Professor Jodie Simpson
Scheme PhD Scholarships
Role Investigator
Funding Start 2009
Funding Finish 2009
GNo G0189748
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

20083 grants / $311,655

Molecular mechanisms and treatment of non-eosinophilic asthma$300,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Associate Professor Jodie Simpson, Doctor Katie Baines
Scheme Project Grant
Role Investigator
Funding Start 2008
Funding Finish 2008
GNo G0188825
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Molecular subtypes of asthma defined by gene expression profiling$9,955

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Doctor Katie Baines
Scheme Early Career Researcher Grant
Role Lead
Funding Start 2008
Funding Finish 2008
GNo G0189618
Type Of Funding Internal
Category INTE
UON Y

American Thoracic Society, Metro Toronto Convention Centre, 16/5/2008 - 21/5/2008$1,700

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Doctor Katie Baines
Scheme Travel Grant
Role Lead
Funding Start 2008
Funding Finish 2008
GNo G0188599
Type Of Funding Internal
Category INTE
UON Y

20061 grants / $18,837

Molecular Pathogenesis of Non-Eosinophilic Asthma$18,837

Funding body: Asthma Foundation of New South Wales

Funding body Asthma Foundation of New South Wales
Project Team Doctor Katie Baines, Conjoint Professor Peter Gibson
Scheme PhD Scholarships
Role Lead
Funding Start 2006
Funding Finish 2006
GNo G0185985
Type Of Funding Donation - Aust Non Government
Category 3AFD
UON Y

20041 grants / $37,837

Molecular Pathogensis of Non-Eosinphilic Asthma$37,837

Funding body: Asthma Foundation of New South Wales

Funding body Asthma Foundation of New South Wales
Project Team Conjoint Professor Peter Gibson, Professor Rodney Scott, Doctor Katie Baines
Scheme PhD Scholarships
Role Investigator
Funding Start 2004
Funding Finish 2004
GNo G0183715
Type Of Funding Donation - Aust Non Government
Category 3AFD
UON Y
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Research Supervision

Number of supervisions

Completed1
Current5

Total current UON EFTSL

Masters0.4
PhD1.2

Current Supervision

Commenced Research Title / Program / Supervisor Type
2015 Dietary Fibre As A Modulator of Inflammation In Asthma
Medical Science, Faculty of Health and Medicine
Co-Supervisor
2015 Fruit and Vegetable Extract for the Reduction of Obesity-Induced Inflammation
Medical Science, Faculty of Health and Medicine
Co-Supervisor
2014 The Effects of Galectin-3 on Alveolar Macrophage Function in Asthma
General Medicine, Faculty of Health and Medicine
Co-Supervisor
2013 The Role of Comorbidities and Inflammation in COPD
General Medicine, Faculty of Health and Medicine
Co-Supervisor
2012 Fatty Acids and the Innate Immune Response
Medical Science, Faculty of Health and Medicine
Co-Supervisor

Past Supervision

Year Research Title / Program / Supervisor Type
2014 Epigenetic Regulation of Airway Inflammation in Asthma
General Medicine, Faculty of Health and Medicine
Co-Supervisor
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News

New study to examine fibre effect on asthma

June 15, 2015

Respiratory researchers from the University of Newcastle and HMRI are looking into whether a high-fibre diet can reduce airway inflammation in people with asthma.

Associate Professor Lisa Wood

Fruit-and-veg capsule set to combat obesity impacts

March 24, 2014

Hunter Medical Research Institute researchers are examining whether a simple fruit-and-vegetable supplement, taken in capsule form, can reduce inflammation produced by fat cells and thereby lower the risk of heart disease, diabetes, asthma and cancers in overweight people.

Dr Katie Baines

Position

Postdoctoral Research Fellow
Respiratory Medicine
School of Medicine and Public Health
Faculty of Health and Medicine

Contact Details

Email katherine.baines@newcastle.edu.au
Phone (02) 40420090
Fax (02) 40420046

Office

Room Room 2109 Level 2 West Wing
Building Hunter Medical Research Institute
Location HMRI Building

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