Dr Katie Baines

Postdoctoral Research Fellow

School of Medicine and Public Health

Career Summary

Biography

Dr Baines is a post doctoral researcher in the Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, and the Priority Research Centre for Asthma and Respiratory Disease. Her second 3 year post-doctoral fellowship commenced in January 2012 through The University of Newcastle, and prior to this she received a research fellowship through (2008-11) funded through Xstrata Coal and HMRI. As an early career post doctoral researcher; Dr Baines manages a semi independent molecular mechanisms group within Professor Peter Gibson’s laboratory. Dr Baines interest in respiratory medicine began when she commenced PhD studies in late 2003 (awarded in 2008), on molecular mechanisms involved in the pathogenesis of noneosinophilic asthma, particularly involving neutrophils. Throughout her PhD she was supported with scholarships from The Asthma Foundation of NSW and the Asthma CRC. Dr Baines is committed to furthering a full-time career in medical research. Her research interests surround the role of gene-environment interactions in the development and pathogenesis of respiratory diseases including asthma and COPD. Dr Baines research uses high throughput genomics technologies to understand more about molecular mechanisms, particularly phenotype definition, biomarker identification and the relationship of phenotypes to clinical outcomes and treatment responses. She is also interested in how respiratory disease phenotypes evolve over time, with regard to the impact of medication use such as inhaled corticosteroids and macrolides, and environmental exposures such as diet and microbial infection. Dr Baines research has led to a number of important contributions to the knowledge base particularly the role of neutrophils and gene expression in asthma and COPD. She has shown that airway neutrophils have an impaired innate immune response in asthma; however blood neutrophils are activated in the neutrophilic phenotype of asthma which is associated with systemic inflammation, a key feature of this phenotype. Dr Baines has defined transcriptional phenotypes of asthma using gene expression profiling of induced sputum and blood, proving the existence of phenotypes as well as the involvement of specific pathways (IL1 and TNF) in the pathogenesis of neutrophilic airway inflammation. Dr Baines has recently identified novel immune genes that are associated with rhinovirus infection of airway epithelial cells in COPD. Since 2009 Dr Baines has published >15 journal articles in highly ranked journals (Thorax, ERJ, JACI), that have been cited 138 times at present. She also has 2 book chapters, 1 Australian Provisional Patent and >38 conference abstracts. Dr Baines has obtained several awards, including the New and Emerging Researcher Awards in 2011 from the Australian Lung Foundation and the Thoracic Society of Australia and New Zealand. She has been awarded 7 competitive travel grant awards, including the esteemed Janet Elder Travel Grant in 2011 and the HMRI Pulse Education Prize in 2010. Dr Baines currently co-supervises 3 PhD students, and was primary supervisor to an honours student who received Class 1 honours in 2012. She is committed to providing a supportive environment for students to grow and learn the skills that will allow them to be successful in their independent research in the future.

Research Expertise

Katie is a laboratory based researcher with expertise in many laboratory methods, including using molecular techniques to understand more about the pathogenesis of respiratory diseases, including asthma and chronic obstructive pulmonary disease (COPD). She has particularl interest in using transcriptomics to understand how environmental influences in predisposed individuals can lead to the development of respiratory disease and different phenotypes of disease. She is also particularly interested in the role of inflammatory cells especially neutrophils in asthma and COPD, and the effects of environmental exposures including medications, diet and infection.

Collaborations
Dr Baines is involved in several successful collaborations, both locally and nationally. 1. Prof Anne Chang, Menzies School of Health and University of Queensland: A new multi-site study investigating airway and systemic markers and mechanisms of Protracted Bacterial Bronchitis in children. Subject of an NHMRC funded grant 2013-2016 2. Dr Manuel Ferreira, University of Queensland: Characterisation of the asthma transcriptome using RNA-seq. Subject of a UQ Collaborative Seed Funding Grant 2012. 3. Dr Brian Oliver and Prof Dominik Hartl, Woolcock Research Institute, University of Sydney, and University of Tubingen, Germany. Neutrophil responses to rhinovirus infection in asthma. Subject of a pending NHMRC grant for 2014. Local collaborations: 1. Prof Peter Gibson and Dr Jodie Simpson: Markers and Mechanisms of severe asthma inflammatory phenotypes. Subject of a NHMRC grant 2013-2015. 2. Dr Vanessa McDonald and Prof Peter Gibson: Phenotype based management of severe asthma. Funded by HMRI and John Hunter Hospital Charitable Trust 2012. 2. Dr Lisa Wood: Effects of diet, including antioxidant withdrawal and fatty acids on gene expression in asthma. 3. A/Prof Peter Wark: Rhinovirus infection and changes in gene expression in primary bronchial epithelial cells in COPD and asthma.


Qualifications

  • PhD, University of Newcastle
  • Bachelor of Biomedical Sciences, University of Newcastle
  • Bachelor of Biomedical Sciences (Hons), University of Newcastle

Keywords

  • Asthma
  • COPD
  • Epigenetics
  • Gene Expression
  • Inflammation
  • Innate Immunity
  • Neutrophils

Fields of Research

CodeDescriptionPercentage
110203Respiratory Diseases100

Professional Experience

UON Appointment

DatesTitleOrganisation / Department
1/01/2015 - 31/12/2015Postdoctoral Research FellowUniversity of Newcastle
School of Medicine and Public Health
Australia

Academic appointment

DatesTitleOrganisation / Department
1/01/2015 - Fellow UON
UoN Research Fellowship
University of Newcastle
School of Medicine and Public Health
Australia
1/01/2012 - Post Doctoral Research FellowUniversity of Newcastle
School of Medicine and Public Health
Australia
1/05/2008 - 1/12/2011Post Doctoral FellowUniversity of Newcastle
School of Medicine and Public Health
Australia
1/04/2008 - 1/04/2011Fellow
Hunter Medical Research Institute:- Project Grant
University of Newcastle
School of Medicine and Public Health
Australia
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Chapter (2 outputs)

YearCitationAltmetricsLink
2013Baines KJ, Simpson JL, Gibson PG, 'Chapter 17: Biology of Neutrophils.', Middleton¿s Allergy Principles and Practice., Elsevier, Philadelphia, PA, USA 280-291 (2013)
2009Simpson JL, Baines KJ, Gibson PG, 'Biology of neutrophils', Middleton's Allergy: Principles & Practice, Mosby, Philadelphia, Pennsylvania 283-294 (2009) [B1]
Co-authorsPeter Gibson, Jodie Simpson

Journal article (30 outputs)

YearCitationAltmetricsLink
2015Baines KJ, Backer V, Gibson PG, Powel H, Porsbjerg CM, 'Impaired lung function is associated with systemic inflammation and macrophage activation.', Eur Respir J, 45 557-559 (2015) [C1]
DOI10.1183/09031936.00187514Author URL
Co-authorsPeter Gibson
2015Gao P, Gibson PG, Baines KJ, Yang IA, Upham JW, Reynolds PN, et al., 'Anti-inflammatory deficiencies in neutrophilic asthma: reduced galectin-3 and IL-1RA/IL-1 beta', RESPIRATORY RESEARCH, 16 (2015)
DOI10.1189/s12931-014-0163-5Author URL
Co-authorsJodie Simpson, Peter Gibson
2015Baines KJ, Backer V, Gibson PG, Powell H, Porsbjerg CM, 'Investigating the effects of arctic dietary intake on lung health.', Eur J Clin Nutr, (2015)
DOI10.1038/ejcn.2015.85Author URL
Co-authorsPeter Gibson
2015Scott HA, Latham JR, Callister R, Pretto JJ, Baines K, Saltos N, et al., 'Acute exercise is associated with reduced exhaled nitric oxide in physically inactive adults with asthma', Annals of Allergy, Asthma and Immunology, (2015)

Background: Although exercise has multiple health benefits, relatively little attention has been paid to its potential therapeutic effects in those with asthma. Objective: To examine the effects of acute exercise on inflammation in physically inactive and active adults with asthma. Methods: Fourteen adults with asthma (n= 6 physically inactive, n= 8 physically active) completed (1) 30 minutes of moderate-intensity exercise on a treadmill and (2) 30 minutes of rest in random order, with 4 weeks between sessions. Exhaled nitric oxide (eNO) was measured before and after the intervention (0, 0.5, 1, 2, 4, and 24 hours). Blood inflammatory mediators were measured before and after the intervention (0, 2, and 24 hours). Results: Physically inactive participants had a significant decrease in eNO 4 hours after exercise (-4.8 ppb,-6.4 to-0.5 ppb, P= .028), which was not observed in physically active participants (P= .362). Interluekin-1 receptor antagonist increased in the physically inactive group 2 hours after exercise, with this increase strongly correlated with the decrease in eNO at 4 hours (R=-0.685, P= .007) and 24 hours (R=-0.659, P=.014) after exercise. Interleukin-6 was increased significantly 2 hours after exercise in physically inactive participants. Blood neutrophils and nuclear factor erythroid 2-like 2 gene expression were increased 2hours after exercise in the overall cohort. Conclusion: This study demonstrates that acute moderate-intensity exercise is associated with decreased eNO in physically inactive adults with asthma and suggests that interluekin-1 receptor antagonist could have a role in mediating this effect. The attenuated response in physically active participants might be due to the sustained anti-inflammatory effects of exercise training. Future studies should investigate the impact of exercise intensity and exercise training on airway inflammation in those with asthma. Trial registration: Australian New Zealand Clinical Trials Registry (http://www.anzctr.org.au), registration number ACTRN12613001014741.

DOI10.1016/j.anai.2015.04.002
Co-authorsRobin Callister, Lisa Wood, Hayley Scott
2015Fu J-J, McDonald VM, Baines KJ, Gibson PG, 'Airway IL-1ß and systemic inflammation as predictors of future exacerbation risk in asthma and COPD', CHEST Journal, (2015)
DOI10.1378/chest.14-2337
2014Baines KJ, Upham JW, Yerkovich ST, Chang AB, Marchant JM, Carroll M, et al., 'Mediators of neutrophil function in children with protracted bacterial bronchitis', Chest, 146 1013-1020 (2014) [C1]
DOI10.1378/chest.14-0131
CitationsScopus - 1
Co-authorsPeter Gibson, Jodie Simpson
2014Simpson JL, Baines KJ, Ryan N, Gibson PG, 'Neutrophilic asthma is characterised by increased rhinosinusitis with sleep disturbance and GERD', Asian Pacific Journal of Allergy and Immunology, 32 66-74 (2014) [C1]

Background: Asthma is a heterogeneous inflammatory disease and eosinophilic, noneosinophilic and neutrophilic forms are recognised. While clinically similar to eosinophilic asthma, patients with non-eosinophilic asthma have different responses to treatment and little is known about the triggers of symptoms and inflammation. Objective: This study sought to characterise asthma control, exacerbation frequency and potential triggers of non-eosinophilic and specifically neutrophilic asthma such as infection, gastroesophageal reflux disease, and rhinosinusitis. Methods: Adults with asthma (n=65; doctor's diagnosis plus demonstrated response to bronchodilator and/or airways hyperresponsiveness to hypertonic saline) were recruited from the Respiratory and Sleep Medicine Ambulatory Care Service at John Hunter Hospital, NSW, Australia. Questionnaires were administered to assess gastroesophageal reflux disease, rhinosinusitis and asthma control. A sputum induction was performed and sputum was processed for assessment of inflammatory cells, infection, and lipid laden macrophages (Oil Red O). Results: Participants with neutrophilic asthma (n=11, 23%) had a higher frequency of primary care doctor visits for asthma exacerbations and a high prevalence (>70%) of chest infections in the previous 12 months. There was also an increased prevalence of rhinosinusitis (64%) and increased symptoms of gastroesophageal reflux disease compared to those with eosinophilic asthma. Conclusions: The clinical pattern of neutrophilic asthma is different from paucigranulocytic and eosinophilic asthma with evidence of abnormal upper airways responses. Specific and targeted treatment of these airway problems may assist in the control and management of neutrophilic asthma.

DOI10.12932/AP0322.32.1.2014
CitationsScopus - 1
Co-authorsPeter Gibson, Nicole Ryan, Jodie Simpson
2014Simpson JL, Phipps S, Baines KJ, Oreo KM, Gunawardhana L, Gibson PG, 'Elevated expression of the NLRP3 inflammasome in neutrophilic asthma', European Respiratory Journal, 43 1067-1076 (2014) [C1]

Asthma is a heterogeneous inflammatory airways disorder where interleukin (IL)-1ß is thought to be a key mediator, especially in the neutrophilic subtype of asthma. The generation of active IL-1ß requires proteolytic cleavage typically mediated through the formation of a caspase-1-containing inflammasome. This study hypothesised that an IL-1ß endotype associated with the nucleotide-binding domain, leucine-rich repeat-containing family protein (NLRP)3/apoptosis-associated speck-like protein containing a caspase-recruitment domain (ASC)/caspase-1 inflammasome is characteristic of patients with the neutrophilic subtype of asthma. Participants with asthma (n=85) and healthy controls (n=27) underwent clinical assessment, spirometry and sputum induction. Sputum was processed for differential cell count, gene expression and protein mediators. NLRP3 and caspase-1 expression was also determined by immunocytochemistry. Sputum macrophages were isolated (n=8) and gene expression of NLRP3 and IL-1ß determined. There was significantly elevated gene expression of NLRP3, caspase-1, caspase-4, caspase-5 and IL-1ß in participants with neutrophilic asthma. Protein levels of IL-1ß were significantly higher in those with neutrophilic asthma and correlated with sputum IL-8 levels. Sputum macrophages, as well as sputum neutrophils in neutrophilic asthma, expressed NLRP3 and caspase-1 protein. NLRP3 inflammasome is upregulated in neutrophilic asthma and may regulate the inflammation process observed in this asthma phenotype through production of IL-1ß. Copyright © ERS 2014.

DOI10.1183/09031936.00105013
CitationsScopus - 9Web of Science - 9
Co-authorsJodie Simpson, Peter Gibson
2014Murphy VE, Mattes J, Powell H, Baines KJ, Gibson PG, 'Respiratory viral infections in pregnant women with asthma are associated with wheezing in the first 12 months of life', Pediatric Allergy and Immunology, 25 151-158 (2014) [C1]

Background: There are few studies investigating the relationship between respiratory viral infection in pregnancy and asthma in the offspring, and none among mothers with asthma. Infants of mothers with asthma are more likely to wheeze and have a higher risk of developing asthma than infants of non-asthmatic mothers. Methods: A prospective cohort study of viral infection in pregnancy was conducted between 2007 and 2009, and a subgroup of infants of mothers with asthma was followed up at 6 and 12 months of age. During common colds, nasal and throat swabs were collected from mothers and respiratory viruses detected by polymerase chain reaction. Respiratory health of infants was assessed by parent-completed questionnaire. Results: Twelve-month-old infants whose mothers had confirmed viral infections in pregnancy (n = 26) reported more frequent wheeze (40% had 4-12 wheeze attacks compared with 0%), sleep disturbed by wheeze (1 night per week or more in 60% vs. 11%), beta agonist treatment for wheeze (27% vs. 0%), prolonged colds (2 wk or longer 31% vs. 0%), more eczema (40% vs. 6.3%), and parent-perceived asthma (32% vs. 0%), compared with infants whose mothers had common colds without laboratory-confirmed viral infection (n = 16). Conclusions: This study demonstrates a relationship between maternal respiratory viral infection in pregnancy and wheezing illness in infants of mothers with asthma. Viral infections are the most common cause of asthma exacerbations in pregnancy, and infants of asthmatic mothers are at increased risk of asthma themselves. Further research is needed to elucidate the mechanisms involved. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

DOI10.1111/pai.12156
CitationsScopus - 2Web of Science - 2
Co-authorsPeter Gibson, Vanessa Murphy, Joerg Mattes
2014Oreo KM, Gibson PG, Simpson JL, Wood LG, Mcdonald VM, Baines KJ, 'Sputum ADAM8 expression is increased in severe asthma and COPD', Clinical and Experimental Allergy, 44 342-352 (2014) [C1]

Background: Severe asthma and chronic obstructive pulmonary disease (COPD) are chronic inflammatory airway diseases in which the mechanisms are not fully understood. A disintegrin and metalloproteinase domain 8 (ADAM8) is an enzyme expressed on most leucocytes and may be important for facilitating leucocyte migration in respiratory disease. Objective: To investigate ADAM8 mRNA and protein expression in asthma and COPD and its relationship between asthma severity and inflammatory phenotypes. Methods: Induced sputum was collected from 113 subjects with asthma (severe n = 31, uncontrolled n = 39 and controlled n = 35), 20 subjects with COPD and 21 healthy controls. Sputum ADAM8 mRNA expression was measured by qPCR, and soluble ADAM8 (sADAM8) protein was measured in the sputum supernatant by validated ELISA. Results: ADAM8 mRNA correlated with ADAM8 protein levels (r = 0.27, P < 0.01). ADAM8 mRNA (P = 0.004) and sADAM8 protein (P = 0.014) levels were significantly higher in both asthma and COPD compared with healthy controls. ADAM8 mRNA (P = 0.035) and sADAM8 protein (P = 0.002) levels were significantly higher in severe asthma compared with controlled asthma. Total inflammatory cell count (P < 0.01) and neutrophils (P < 0.01) were also elevated in severe asthmatic sputum. Although ADAM8 mRNA was significantly higher in eosinophilic and neutrophilic asthma (P < 0.001), sADAM8 did not differ between asthma inflammatory phenotypes. ADAM8 expression positively correlated with sputum total cell count and sputum neutrophils. Conclusions and Clinical Relevance: ADAM8 expression is increased in both severe asthma and COPD and associated with sputum total cell count and neutrophils. ADAM8 may facilitate neutrophil migration to the airways in severe asthma and COPD. © 2013 John Wiley & Sons Ltd.

DOI10.1111/cea.12223
CitationsScopus - 1Web of Science - 1
Co-authorsVanessa Mcdonald, Lisa Wood, Peter Gibson, Jodie Simpson
2014Gunawardhana LP, Gibson PG, Simpson JL, Powell H, Baines KJ, 'Activity and expression of histone acetylases and deacetylases in inflammatory phenotypes of asthma', Clinical & Experimental Allergy, 44 47-57 (2014) [C1]
DOI10.1111/cea.12168Author URL
CitationsScopus - 2Web of Science - 2
Co-authorsJodie Simpson, Peter Gibson
2014Simpson JL, Powell H, Baines KJ, Milne D, Coxson HO, Hansbro PM, Gibson PG, 'The Effect of Azithromycin in Adults with Stable Neutrophilic COPD: A Double Blind Randomised, Placebo Controlled Trial', PLOS ONE, 9 (2014) [C1]
DOI10.1371/journal.pone.0105609Author URL
CitationsScopus - 3Web of Science - 1
Co-authorsJodie Simpson, Philip Hansbro, Peter Gibson
2014Baines KJ, Simpson JL, Wood LG, Scott RJ, Fibbens NL, Powell H, et al., 'Sputum gene expression signature of 6 biomarkers discriminates asthma inflammatory phenotypes', Journal of Allergy and Clinical Immunology, 133 997-1007 (2014) [C1]

Background Airway inflammation is associated with asthma exacerbation risk, treatment response, and disease mechanisms. Objective This study aimed to identify and validate a sputum gene expression signature that discriminates asthma inflammatory phenotypes. Methods An asthma phenotype biomarker discovery study generated gene expression profiles from induced sputum of 47 asthmatic patients. A clinical validation study (n = 59 asthmatic patients) confirmed differential expression of key genes. A 6-gene signature was identified and evaluated for reproducibility (n = 30 asthmatic patients and n = 20 control subjects) and prediction of inhaled corticosteroid (ICS) response (n = 71 asthmatic patients). Receiver operating characteristic curves were calculated, and area under the curve (AUC) values were reported. Results From 277 differentially expressed genes between asthma inflammatory phenotypes, we identified 23 genes that showed highly significant differential expression in both the discovery and validation populations. A signature of 6 genes, including Charcot-Leydon crystal protein (CLC); carboxypeptidase A3 (CPA3); deoxyribonuclease I-like 3 (DNASE1L3); IL-1ß (IL1B); alkaline phosphatase, tissue-nonspecific isozyme (ALPL); and chemokine (C-X-C motif) receptor 2 (CXCR2), was reproducible and could significantly (P <.0001) discriminate eosinophilic asthma from other phenotypes, including patients with noneosinophilic asthma (AUC, 89.6%), paucigranulocytic asthma (AUC, 92.6%), or neutrophilic asthma (AUC, 91.4%) and healthy control subjects (AUC, 97.6%), as well as discriminating patients with neutrophilic asthma from those with paucigranulocytic asthma (AUC, 85.7%) and healthy control subjects (AUC, 90.8). The 6-gene signature predicted ICS response (>12% change in FEV1; AUC, 91.5%). ICS treatment reduced the expression of CLC, CPA3, and DNASE1L3 in patients with eosinophilic asthma. Conclusions A sputum gene expression signature of 6 biomarkers reproducibly and significantly discriminates inflammatory phenotypes of asthma and predicts ICS treatment response. This signature has the potential to become a useful diagnostic tool to assist in the clinical diagnosis and management of asthma. © 2013 American Academy of Allergy, Asthma & Immunology.

DOI10.1016/j.jaci.2013.12.1091
CitationsScopus - 11Web of Science - 12
Co-authorsJodie Simpson, Lisa Wood, Peter Gibson, Rodney Scott
2014Gunawardhana LP, Baines KJ, Mattes J, Murphy VE, Simpson JL, Gibson PG, 'Differential DNA methylation profiles of infants exposed to maternal asthma during pregnancy', Pediatric Pulmonology, 49 852-862 (2014) [C1]

Background Asthma is a complex disease that involves both genetic factors and environmental exposures. Aberrant epigenetic modifications, such as DNA methylation, may be important in asthma development. Fetal exposure to maternal asthma during critical periods of in utero development may lead to epigenetic alterations that predispose infants to a greater risk of developing asthma themselves. We investigated alterations in the DNA methylation profile of peripheral blood from infants exposed to maternal asthma during pregnancy. Methods Peripheral blood was collected from 12-month-old infants born to women with (n = 25) and without (n = 15) doctor diagnosed asthma during pregnancy. Genomic DNA was extracted, bisulfite converted, and hybridized to Infinium Methylation 27 arrays (Illumina), containing over27,000 CpGs from 14,495 genes. CpG loci in only autosomal genes were classified as differentially methylated at the 99% level (P < 0.01, |DiffScore| > 22 and delta beta >0.06). Results There were 70 CpG loci, corresponding to 67 genes that were significantly differentially methylated. Twelve CpG loci (11 genes) showed greater than 10% comparative difference in DNA methylation, including hyper-methylated loci of FAM181A, MRI1, PIWIL1, CHFR, DEFA1, MRPL28, AURKA, and hypo-methylated loci of NALP1L5, MAP8KIP3, ACAT2, and PM20D1 in maternal asthma. Methylation of MAPK8IP3 was significantly negatively correlated with maternal blood eosinophils (r = -0.38; P = 0.022), maternal eNO (r = -0.44; P = 0.005), and maternal serum total IgE (r = -0.39, P = 0.015). Methylation of AURKA negatively correlated with maternal hemoglobin (r = -0.43; P = 0.008), infants height (r = -0.51; P < 0.001) and weight (r = -0.36; P = 0.021). Methylation of PM20D1 was lower in infants born to mothers with asthma on inhaled corticosteroid treatment. Methylation of PM20D1 was lower and MRI1 was higher in infants born to atopic mothers without asthma. Conclusions In an Australian study population, exposure to maternal asthma during pregnancy is associated with differential methylation profiles of infants' peripheral blood DNA, which may act as risk factors for future asthma development. © 2013 Wiley Periodicals, Inc.

DOI10.1002/ppul.22930
CitationsScopus - 3Web of Science - 2
Co-authorsPeter Gibson, Vanessa Murphy, Jodie Simpson, Joerg Mattes
2014Gunawardhana LP, Gibson PG, Simpson JL, Benton MC, Lea RA, Baines KJ, 'Characteristic DNA methylation profiles in peripheral blood monocytes are associated with inflammatory phenotypes of asthma.', Epigenetics, 9 1302-1316 (2014) [C1]
DOI10.4161/epi.33066Author URL
CitationsScopus - 2Web of Science - 3
Co-authorsPeter Gibson, Jodie Simpson
2014Baines KJ, Pavord ID, Gibson PG, 'The role of biomarkers in the management of airways disease.', Int J Tuberc Lung Dis, 18 1264-1268 (2014) [C1]
DOI10.5588/ijtld.14.0226Author URL
CitationsScopus - 3Web of Science - 1
Co-authorsPeter Gibson
2013Kaiko GE, Loh Z, Spann K, Lynch JP, Lalwani A, Zheng Z, et al., 'Toll-like receptor 7 gene deficiency and early-life Pneumovirus infection interact to predispose toward the development of asthma-like pathology in mice', JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 131 1331-U132 (2013) [C1]
DOI10.1016/j.jaci.2013.02.041Author URL
CitationsScopus - 19Web of Science - 18
Co-authorsJodie Simpson, Paul Foster
2013Simpson JL, McDonald VM, Baines KJ, Oreo KM, Wang F, Hansbro PM, Gibson PG, 'Influence of Age, Past Smoking, and Disease Severity on TLR2, Neutrophilic Inflammation, and MMP-9 Levels in COPD', MEDIATORS OF INFLAMMATION, (2013) [C1]
DOI10.1155/2013/462934Author URL
CitationsScopus - 6Web of Science - 6
Co-authorsPhilip Hansbro, Jodie Simpson, Vanessa Mcdonald, Peter Gibson
2013Baines KJ, Hsu AC-Y, Tooze M, Gunawardhana LP, Gibson PG, Wark PAB, 'Novel immune genes associated with excessive inflammatory and antiviral responses to rhinovirus in COPD', RESPIRATORY RESEARCH, 14 (2013) [C1]
DOI10.1186/1465-9921-14-15Author URL
CitationsScopus - 7Web of Science - 8
Co-authorsAlan Hsu, Peter Gibson, Peter Wark
2013Fu J-J, Baines KJ, Wood LG, Gibson PG, 'Systemic Inflammation Is Associated with Differential Gene Expression and Airway Neutrophilia in Asthma', OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY, 17 187-199 (2013) [C1]
DOI10.1089/omi.2012.0104Author URL
CitationsScopus - 11Web of Science - 9
Co-authorsLisa Wood, Peter Gibson
2012Wood LG, Baines KJ, Fu J, Scott HA, Gibson PG, 'The neutrophilic inflammatory phenotype is associated with systemic inflammation in asthma', Chest, 142 86-93 (2012) [C1]
CitationsScopus - 46Web of Science - 43
Co-authorsLisa Wood, Peter Gibson, Hayley Scott
2011Baines KJ, Simpson JL, Gibson PG, 'Innate immune responses are increased in chronic obstructive pulmonary disease', PLoS ONE, 36 e18426 (2011) [C1]
DOI10.1371/journal.pone.0018426
CitationsScopus - 27Web of Science - 19
Co-authorsPeter Gibson, Jodie Simpson
2011Baines KJ, Simpson JL, Wood LG, Scott R, Gibson PG, 'Systemic upregulation of neutrophil a-defensins and serine proteases in neutrophilic asthma', Thorax, 66 942-947 (2011) [C1]
CitationsScopus - 15Web of Science - 15
Co-authorsRodney Scott, Jodie Simpson, Lisa Wood, Peter Gibson
2011Baines KJ, Simpson JL, Wood LG, Scott R, Gibson PG, 'Transcriptional phenotypes of asthma defined by gene expression profiling of induced sputum samples', Journal of Allergy and Clinical Immunology, 127 153.e9-160.e9 (2011) [C1]
DOI10.1016/j.jaci.2010.10.024
CitationsScopus - 67Web of Science - 55
Co-authorsLisa Wood, Peter Gibson, Rodney Scott, Jodie Simpson
2011Wang F, He XY, Baines KJ, Gunawardhana LP, Simpson JL, Li F, Gibson PG, 'Different inflammatory phenotypes in adults and children with acute asthma', European Respiratory Journal, 38 567-574 (2011) [C1]
DOI10.1183/09031936.00170110
CitationsScopus - 28Web of Science - 25
Co-authorsPeter Gibson, Jodie Simpson
2010Li J, Wang W, Baines KJ, Bowden NA, Hansbro PM, Gibson PG, et al., 'IL-27/IFN-y induce MyD88-dependent steroid-resistant airway hyperresponsiveness by inhibiting glucocorticoid signaling in macrophages', Journal of Immunology, 185 4401-4409 (2010) [C1]
DOI10.4049/jimmunol.1001039
CitationsScopus - 35Web of Science - 32
Co-authorsMing Yang, Philip Hansbro, Peter Gibson, Paul Foster, Nikola Bowden
2010Baines KJ, Simpson JL, Bowden NA, Scott R, Gibson PG, 'Differential gene expression and cytokine production from neutrophils in asthma phenotypes', European Respiratory Journal, 35 522-531 (2010) [C1]
DOI10.1183/09031936.00027409
CitationsScopus - 30Web of Science - 24
Co-authorsNikola Bowden, Rodney Scott, Peter Gibson, Jodie Simpson
2009Baines KJ, Wood LG, Gibson PG, 'The nutrigenomics of asthma: Molecular mechanisms of airway neutrophilia following dietary antioxidant withdrawal', OMICS: A Journal of Integrative Biology, 13 355-365 (2009) [C1]
DOI10.1089/omi.2009.0042
CitationsScopus - 13Web of Science - 11
Co-authorsPeter Gibson, Lisa Wood
2009Baines KJ, Simpson JL, Scott R, Gibson PG, 'Immune responses of airway neutrophils are impaired in asthma', Experimental Lung Research, 35 554-569 (2009) [C1]
DOI10.1080/01902140902777490
CitationsScopus - 14Web of Science - 15
Co-authorsRodney Scott, Peter Gibson, Jodie Simpson
2009Simpson JL, Baines KJ, Boyle MJ, Scott R, Gibson PG, 'Oncostatin M (OSM) is increased in asthma with incompletely reversible airflow obstruction', Experimental Lung Research, 35 781-794 (2009) [C1]
DOI10.3109/01902140902906412
CitationsScopus - 9Web of Science - 11
Co-authorsRodney Scott, Peter Gibson, Jodie Simpson
Show 27 more journal articles

Conference (65 outputs)

YearCitationAltmetricsLink
2015McDonald V, Wark P, Baines K, Gibson P, 'The multidimensional components of severe asthma', Am J Resp Crit Care Med (2015)
2015Tang F, Gibson P, Foxley G, Burgess J, Baines K, Oliver B, 'Neutrophils from people with uncontrolled asthma have a deficient CXCL8 response to bacteria but not to viruses', Am J Resp Crit Care Med (2015)
2015Baines K, Wright T, Simpson J, McDonald V, Wood L, Gibson P, 'Accumulation of neutrophil extracellular traps is associated with inflammation in neutrophilic asthma and COPD', Am J Resp Crit Care Med (2015)
2015McDonald V, Wark P, Baines K, Gibson P, 'The multidimensional components of severe asthma', Respirology (2015)
2015Tang F, Gibson P, Foxley G, Burgess J, Baines K, Oliver B, 'Deficient CXCL8 response to bacteria but not to viruses in neutrophils from people with uncontrolled asthma', Respirology (2015)
2015Tang F, Hansbro P, Burgess J, Baines K, Oliver B, 'Neutrophils display immunoregulatory roles in rhinovirus infections', Respirology (2015)
2015Baines K, Wright T, Simpson J, McDonald V, Wood L, Gibson P, 'Excessive neutrophil extracellular traps are associated with inflammation in chronic airway disease', Respirology (2015)
2015Upham J, Chen A, Carroll M, Petsky H, Pizzutto S, Yerkovich S, et al., 'Immune responses to nontypeable haemophilus influenza in protracted bacterial bronchitis.', Respirology (2015)
2015Erriah M, Gao P, Baines K, Gibson P, Simpson J, 'Sputum galectin-3 expression is associated with eosinophils in COPD', Respirology (2015)
2015Tang F, Hansbro P, Burgess J, Baines K, Oliver B, 'A novel immunoregulatory role of neutrophils in viral infections' (2015)
2014Wright T, Gibson P, Simpson J, Mcdonald V, Wood L, Baines K, 'ALARMINS IN ASTHMA AND COPD: RELATIONSHIPS TO INFLAMMATORY PHENOTYPES AND DISEASE SEVERITY', RESPIROLOGY (2014) [E3]
Author URL
Co-authorsLisa Wood, Peter Gibson, Jodie Simpson, Vanessa Mcdonald
2014Baines K, Simpson J, Wood L, Scott R, Fibbens N, Powell H, et al., 'SPUTUM GENE EXPRESSION OF SIX MARKERS IDENTIFIES ASTHMA INFLAMMATORY PHENOTYPE AND CORTICOSTEROID RESPONSE', RESPIROLOGY (2014) [E3]
Author URL
Co-authorsLisa Wood, Rodney Scott, Jodie Simpson
2014Baines K, Upham J, Yerkovich S, Chang A, Marchant J, Carroll M, et al., 'INTERLEUKIN-1B IS RELATED TO CLINICAL OUTCOMES IN PROTRACTED BACTERIAL BRONCHITIS', RESPIROLOGY (2014) [E3]
Author URL
Co-authorsJodie Simpson, Peter Gibson
2014Simpson J, Gao P, Baines K, Yang I, Reynolds P, Hodge S, et al., 'GALECTIN 3 AND GALECTIN 3 BINDING PROTEIN IN ASTHMA INFLAMMATORY SUBTYPES', RESPIROLOGY (2014) [E3]
Author URL
Co-authorsJodie Simpson, Peter Gibson
2014Tang F, Van Ly D, Reading P, Spann K, Hartl D, Burgess JK, et al., 'Neutrophils Respond To Viral Surrogates And Respiratory Viruses', Am J Resp Crit Care Med (2014)
2014Fu JJ, McDonald VM, Baines KJ, Mao B, Gibson PG, 'Airway IL-1 Pathway Activation And Systemic Inflammation Predict Future Exacerbation Risk In Asthma And COPD', Am J Resp Crit Care Med (2014)
2014Baines K, Backer V, Gibson P, Powell H, Porsbjerg C, 'Systemic inflammation, diet, and place of residence modify lung function in Greenland Inuit.', Eur Resp J (2014)
2014Sverrild A, Baines K, Backer V, Gibson P, Porsbjerg C, 'Increased IL-33 expression is related to high levels of TLR-2 and -4 in steroid-free subjects with asthma', Eur Resp J (2014)
2014Porsbjerg C, Baines K, Sverrild A, Backer V, Gibson P, 'Eosinophilic airway inflammation is associated with increased TLR2 and TLR4 expression in adult asthmatics.', Eur Resp J (2014)
2014Tang F, Van Ly D, Reading P, Baines KJ, Spann K, Burgess J, et al., 'Viral surrogates and respiratory viruses differentially activate neutrophils', Respirology (2014)
2013Gunawardhana LP, Baines KJ, Mattes J, Murphy VE, Simpson JL, Gibson PG, 'EPIGENETIC ALTERATIONS IN INFANTS ASSOCIATED WITH MATERNAL ASTHMA DURING PREGNANCY', RESPIROLOGY (2013) [E3]
Author URL
Co-authorsJoerg Mattes, Jodie Simpson, Vanessa Murphy, Peter Gibson
2013Simpson JL, Baines KJ, Ryan NM, Gibson PG, 'NEUTROPHILIC ASTHMA IS CHARACTERIZED BY INCREASED GERD AND RHINOSINUSITIS WITH SLEEP DISTURBANCE', RESPIROLOGY (2013) [E3]
Author URL
Co-authorsPeter Gibson, Jodie Simpson, Nicole Ryan
2013Baines KJ, Simpson JL, Mcdonald VM, Hsu AC, Gibson PG, 'DIFFERENTIAL AIRWAY GENE EXPRESSION IN COPD', RESPIROLOGY (2013) [E3]
Author URL
Co-authorsPeter Gibson, Alan Hsu, Vanessa Mcdonald, Jodie Simpson
2013Wang G, Baines KJ, Fu JJ, Gibson PG, 'MAST CELL-BASED PHENOTYPES OF ASTHMA IN INDUCED SPUTUM SAMPLES', RESPIROLOGY (2013) [E3]
Author URL
Co-authorsPeter Gibson
2013Baines KJ, Simpson JL, Wood LG, Scott RJ, Fibbens NL, Powell H, et al., 'Sputum gene expression of six markers identifies asthma inflammatory phenotype and corticosteroid response.', Australasian Genomic Technologies Association Annual Scientific Meeting, Gold Coast, QLD (2013)
2013Baines KJ, Upham JW, Yerkovich ST, Chang AB, Marchant J, Carroll M, et al., 'Interleukin-1ß is related to clinical outcomes in protracted bacterial bronchitis', Australasian Society for Immunology, Wellington, NZ (2013)
2012Simpson JL, Phipps S, Baines KJ, Oreo KM, Gibson PG, 'NALP3 INFLAMMASOME ACTIVATION IN NEUTROPHILIC ASTHMA', RESPIROLOGY (2012) [E3]
Author URL
Co-authorsJodie Simpson, Peter Gibson
2012Simpson JL, Phipps S, Baines KJ, Oreo K, Gibson PG, 'NALP3 inflammasome activation in neutrophilic asthma', Respirology, Canberra, ACT (2012) [E3]
Co-authorsPeter Gibson, Jodie Simpson
2012Baines KJ, Simpson JL, Wood LG, Scott RJ, Gibson PG, 'Sputum gene expression of mast cell specific proteases are increased in eosinophilic asthma', Respirology, Canberra, ACT (2012) [E3]
Co-authorsRodney Scott, Jodie Simpson, Peter Gibson, Lisa Wood
2012Baines KJ, Simpson JL, Wood LG, Scott RJ, Gibson PG, 'Induced sputum differential gene expression implicates increased p38 signalling activity in severe asthma', Respirology, Canberra, ACT (2012) [E3]
Co-authorsRodney Scott, Jodie Simpson, Peter Gibson, Lisa Wood
2011Baines KJ, Simpson JL, Scott R, Wood LG, Gibson PG, 'Systemic upregulation of neutrophil a-defensins and serine proteases in neutrophilic asthma', European Respiratory Society Annual Congress 2011 Abstracts, Amsterdam (2011) [E3]
Co-authorsLisa Wood, Rodney Scott, Jodie Simpson, Peter Gibson
2011Baines KJ, Simpson JL, Scott R, Wood LG, Gibson PG, 'Sputum gene expression of mast cell tryptase and carboxypeptidase A3 are increased in eosinophilic asthma', European Respiratory Society Annual Congress 2011 Abstracts, Amsterdam (2011) [E3]
Co-authorsRodney Scott, Jodie Simpson, Lisa Wood, Peter Gibson
2011Baines KJ, Simpson JL, Scott R, Wood LG, Gibson PG, 'Induced sputum differential gene expression implicates increased p38 signalling activity in severe asthma', European Respiratory Society Annual Congress 2011 Abstracts, Amsterdam (2011) [E3]
Co-authorsJodie Simpson, Lisa Wood, Peter Gibson, Rodney Scott
2011Baines KJ, Simpson JL, Scott RJ, Wood LG, Gibson PG, 'Analysis of systemic gene expression according to inflammatory phenotype of asthma.', Respirology (2011)
2011Oliver BG, Tang FS, Van Ly D, Burgess JK, Black JL, Baines KJ, 'Imiquimod, poly I:c and rhinovirus induce interleukin (iL)-6 and IL-8 release from polymorphonuclear cells and peripheral blood mononuclear cells: Effect of dexamethasone', American Journal of Respiratory and Critical Care Medicine, Denver, CO (2011) [E3]
2011Baines KJ, Simpson JL, Scott R, Wood LG, Gibson PG, 'Analysis of systemic gene expression according to inflammatory phenotype of asthma', Respirology, Perth, WA (2011) [E3]
Co-authorsPeter Gibson, Jodie Simpson, Rodney Scott, Lisa Wood
2011Baines KJ, Tooze MK, Wark PA, 'Rhinovirus infected airway epithelial cells have an increased pro-inflammatory response in COPD', Respirology, Perth, WA (2011) [E3]
Co-authorsPeter Wark
2011Gunawardhana LP, Baines KJ, Simpson JL, Mattes J, Murphy VE, Gibson PG, 'Maternal asthma is associated with alterations in DNA methylation profile of peripheral blood of infants', Respirology, Perth, WA (2011) [E3]
Co-authorsJodie Simpson, Peter Gibson, Vanessa Murphy, Joerg Mattes
2011Oreo K, Baines KJ, Gibson PG, Hansbro PM, 'Pro-inflammatory cytokine production is impaired in response to TLR2 activation in healthy ageing and COPD', Respirology, Perth, WA (2011) [E3]
Co-authorsPhilip Hansbro, Peter Gibson
2011Wang F, Xy HA, Baines KJ, Gunawardhana LP, Simpson JL, Ki F, Gibson PG, 'Is chalamydophyla a pneumoniae infection related to non-eosinophilic asthma?', Respirology, Perth, WA (2011) [E3]
Co-authorsJodie Simpson, Peter Gibson
2011Fu J, Baines KJ, Wood LG, Scott HA, Gibson PG, 'Low-grade systemic inflammation is associated with airway neutrophilia in asthma', Respirology, Shanghai (2011) [E3]
Co-authorsLisa Wood, Hayley Scott, Peter Gibson
2011Fu J, Baines KJ, Gibson PG, Scott HA, Wood LG, 'Systemic inflammation mediates airway neutrophilia via the regulation of IL-8 receptor mRNA expression', Respirology, Shanghai (2011) [E3]
Co-authorsPeter Gibson, Lisa Wood, Hayley Scott
2010Baines KJ, Simpson JL, Scott R, Wood LG, Gibson PG, 'Molecular phenotypes of asthma defined by gene expression profiling', American Journal of Respiratory and Critical Care Medicine, New Orleans, LO (2010) [E3]
Co-authorsRodney Scott, Jodie Simpson, Peter Gibson, Lisa Wood
2010Baines KJ, Simpson JL, Scott R, Wood LG, Gibson PG, 'Analysis of systemic gene expression according to inflammatory phenotype of asthma', Biomarker Discovery Conference, Shoal Bay, NSW (2010) [E3]
Co-authorsRodney Scott, Jodie Simpson, Lisa Wood, Peter Gibson
2010Gunawardhana LG, Baines KJ, Simpson JL, Mattes J, Murphy VE, Gibson PG, (Oral) BDCD2010, 'Maternal asthma is associated with alterations in DNA methylation profile of peripheral blood of infants.', Biomarker Discovery Conference, Shoal Bay, NSW (2010)
2010Baines KJ, Simpson JL, Scott RJ, Wood LG, Gibson PG, 'Molecular profiling of asthma defined by gene expression', Respirology, Brisbane, QLD (2010) [E3]
Co-authorsJodie Simpson, Lisa Wood, Peter Gibson
2010Baines KJ, Simpson JL, Scott R, Wood LG, Gibson PG, 'Molecular phenotypes of asthma defined by gene expression profiling', Respirology, Brisbane, QLD (2010) [E3]
Co-authorsLisa Wood, Peter Gibson, Rodney Scott, Jodie Simpson
2009Baines KJ, Simpson JL, Scott R, Wood LG, Gibson PG, 'Genome wide gene expression of induced sputum in non-eosinophilic asthma', AMATA 2009, Katoomba, NSW (2009) [E3]
Co-authorsLisa Wood, Jodie Simpson, Rodney Scott, Peter Gibson
2009Bowden NA, Ashton KA, Stibbard GJ, Cox MB, Baines KJ, Scott R, 'Predicting xeroderma pigmentosum complementation group by gene expression profiling', AMATA 2009, Katoomba, NSW (2009) [E3]
Co-authorsNikola Bowden, Rodney Scott, Katie Ashton
2009Baines KJ, Grissell TV, Gibson PG, Wark PA, 'Molecular mechanisms of rhinovirus infection of primary bronchial epithelial cells', Respirology, Darwin, NT (2009) [E3]
DOI10.1111/j.1440-1843.2009.01503_1.x
Co-authorsPeter Gibson, Peter Wark
2009Baines KJ, Wood LG, Gibson PG, 'Molecular mechanisms of airway neutrophilia following a low antioxidant diet', Respirology, Darwin, NT (2009) [E3]
DOI10.1111/j.1440-1843.2009.01503_1.x
Co-authorsPeter Gibson, Lisa Wood
2009Oreo K, Baines KJ, Gibson PG, Hansbro PM, Simpson JL, 'Toll-like receptor agonists stimulate cytokine release from blood but not airway cells', Respirology, Darwin, NT (2009) [E3]
DOI10.1111/j.1440-1843.2009.01503_1.x
Co-authorsPhilip Hansbro, Jodie Simpson, Peter Gibson
2008Baines KJ, Simpson JL, Scott R, Gibson PG, 'Ageing alters airway and circulating neutrophil function', Respirology, Melbourne, VIC (2008) [E3]
DOI10.1111/j.1440-1843.2008.01252.x
Co-authorsJodie Simpson, Rodney Scott, Peter Gibson
2008Baines KJ, Simpson JL, Scott R, Gibson PG, 'Innate immune responses of airway neutrophils are impaired in neutrophilic asthma', Respirology, Melbourne, VIC (2008) [E3]
DOI10.1111/j.1440-1843.2008.01252.x
Co-authorsPeter Gibson, Jodie Simpson, Rodney Scott
2008Bowden NA, Baines KJ, Cox MB, Scott R, 'Altered gene expression in nucleotide excision repair deficient fibroblasts after UV-light exposure', AACR Meeting Abstracts, San Diego, CA (2008) [E3]
Co-authorsNikola Bowden, Rodney Scott
2008Bowden NA, Baines KJ, Cox MB, Scott R, 'Response to uv-light exposure in fibroblasts with differential nucleotide excision repair capacity', ASMR XVII NSW Scientific Meeting: Programme and Abstracts, Sydney, NSW (2008) [E3]
Co-authorsNikola Bowden, Rodney Scott
2008Bowden NA, Ashton KA, Baines KJ, Cox MB, Scott R, 'Altered gene expression after UV-light induced DNA damage', Conference on Translational Cancer Research: Abstracts, Newcastle, NSW (2008) [E3]
Co-authorsNikola Bowden, Katie Ashton, Rodney Scott
2008Baines KJ, Simpson JL, Scott RJ, Gibson PG, 'Innate Immune Responses of Neutrophils are Impaired in Neutrophilic Asthma', Am J Resp Crit Care Med (2008)
2008Baines KJ, Simpson JL, Scott RJ, Gibson PG, 'Ageing Alters Airway and Circulating Neutrophil Function.', Am J Resp Crit Care Med (2008)
2008Baines KJ, Simpson JL, Scott RJ, Gibson PG, 'Ageing Alters Airway and Circulating Neutrophil Function', Respirology (2008)
2007Baines KJ, Bowden NA, Scott R, Simpson JL, Gibson PG, 'Molecular analysis of neutrophils in asthma subtypes', Respirology (TSANZ Abstracts-Posters), Auckland (2007) [E3]
DOI10.1111/j.1440-1843.2007.001050.x
Co-authorsPeter Gibson, Jodie Simpson, Rodney Scott, Nikola Bowden
2007Baines KJ, Bowden NA, Scott RJ, Simpson JL, Gibson PG, 'Molecular Analysis of Neutrophils in Asthma Subtypes', Am J Resp Crit Care Med (2007)
2007Gibson PG, Baines KJ, Simpson JL, Scott RJ, 'Gene Expression Profiling Identifies Neutrophilic and Eosinophilic Asthma as Distinct Subtypes.', Eur Resp J (2007)
2006Baines KJ, Simpson JL, Scott R, Bell NV, Boyle MJ, Gibson PG, 'Enhanced IL-8 release from neutrophils in non-eosinophilic asthma', Respirology, Canberra (2006) [E3]
Co-authorsPeter Gibson, Rodney Scott, Jodie Simpson
2005Baines KJ, Bell NV, Simpson JL, Scott RJ, Boyle MJ, Gibson PG, 'Enhanced IL-8 Release from Neutrophils in Non-Eosinophilic Asthma', Inflammation Research (2005)
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Grants and Funding

Summary

Number of grants32
Total funding$2,021,631

Click on a grant title below to expand the full details for that specific grant.


20152 grants / $185,222

Targeting neutrophil extracellular traps as a novel therapeutic option in COPD$160,000

Funding body: Australian Lung Foundation

Funding bodyAustralian Lung Foundation
Project TeamDoctor Katie Baines
SchemeBoehringer Ingelheim Chronic Obstructive Pulmonary Disease Research Fellowship
RoleLead
Funding Start2015
Funding Finish2015
GNoG1500407
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

Targeting neutrophil extracellular traps as a novel therapeutic option in COPD$25,222

Funding body: John Hunter Hospital Charitable Trust Fund

Funding bodyJohn Hunter Hospital Charitable Trust Fund
Project TeamDoctor Katie Baines, Conjoint Professor Peter Gibson
SchemeResearch Grant
RoleLead
Funding Start2015
Funding Finish2015
GNoG1500570
Type Of FundingOther Public Sector - State
Category2OPS
UONY

20146 grants / $269,397

Greenland Study$140,000

Funding body: Bispebjerg Hospital

Funding bodyBispebjerg Hospital
Project TeamConjoint Professor Peter Gibson, Doctor Katie Baines, Professor Vibeke Backer
SchemeInternational Collaboration
RoleInvestigator
Funding Start2014
Funding Finish2014
GNoG1400539
Type Of FundingInternational - Non Competitive
Category3IFB
UONY

Identifying biomarkers that predict severe asthma exacerbations during pregnancy$60,000

Funding body: Thoracic Society of Australia and New Zealand

Funding bodyThoracic Society of Australia and New Zealand
Project TeamDoctor Katie Baines
SchemeTSANZ/National Asthma Council Australia - Asthma and Airways Career Development Fellowship
RoleLead
Funding Start2014
Funding Finish2014
GNoG1400730
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

Identifying biomarkers that predict severe asthma exacerbations during pregnancy$27,512

Funding body: John Hunter Hospital Charitable Trust Fund

Funding bodyJohn Hunter Hospital Charitable Trust Fund
Project TeamDoctor Katie Baines, Emeritus Professor Michael Hensley
SchemeResearch Grant
RoleLead
Funding Start2014
Funding Finish2014
GNoG1400631
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

The role of comorbidities and inflammation in Chronic Obstructive Pulmonary Disease (COPD)$20,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamMrs Netsanet Negewo, Associate Professor Vanessa McDonald, Conjoint Professor Peter Gibson, Doctor Katie Baines
SchemePostgraduate Research Scholarship
RoleInvestigator
Funding Start2014
Funding Finish2014
GNoG1401393
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

Predicting who is at risk of worsening lung disease in Cystic Fibrosis$20,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamConjoint Professor Peter Wark, Doctor Katie Baines, Associate Professor Vanessa McDonald, Conjoint Professor Peter Gibson, Associate Professor Scott Bell, Dr David Reid
SchemeProject Grant
RoleInvestigator
Funding Start2014
Funding Finish2014
GNoG1401410
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

Thoracic Society of Australia and New Zealand, Adelaide Australia, 4-9 April 2014$1,885

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding bodyUniversity of Newcastle - Faculty of Health and Medicine
Project TeamDoctor Katie Baines
SchemeTravel Grant
RoleLead
Funding Start2014
Funding Finish2014
GNoG1400186
Type Of FundingInternal
CategoryINTE
UONY

20135 grants / $572,508

Gene Expression Biomarkers Predict Severe Asthma Inflammatory Phenotype, Activation Mechanisms and Treatment Response$449,307

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamDoctor Katie Baines, Conjoint Professor Peter Gibson, Associate Professor Jodie Simpson
SchemeProject Grant
RoleLead
Funding Start2013
Funding Finish2013
GNoG1200188
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Protracted bacterial bronchitis: long term outcomes, systemic and airway predictors of recurrence$76,526

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Anne Chang, Professor John Upham, Conjoint Professor Peter Gibson, Dr Stephanie Yerkovich, Doctor Katie Baines, Dr Sandra Hodge, Mrs Susan Pizzuto, Associate Professor Ian Masters, Dr Helen Buntain
SchemeProject Grant
RoleInvestigator
Funding Start2013
Funding Finish2013
GNoG1200534
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

BD FACSCanto II Violet Laser (405nm) upgrade including Trigon and 2 photomultiplier tubes (PMTs)$25,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamConjoint Professor Peter Wark, Doctor Alan Hsu, Doctor Katie Baines, Associate Professor Jodie Simpson, Conjoint Professor Peter Gibson, Ms Hayley See
SchemeEquipment Grant
RoleInvestigator
Funding Start2013
Funding Finish2013
GNoG1201180
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

DP73 Digital colour and monochrome camera + cellSens software + Xcite120 fluorescence lamp illuminator$20,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamLaureate Professor Paul Foster, Doctor Alan Hsu, Professor Phil Hansbro, Professor Joerg Mattes, Doctor Katie Baines, Associate Professor Jodie Simpson, Professor Rakesh Kumar, Doctor Nicole Hansbro, Doctor Steven Maltby, Doctor Ming Yang, Doctor Gerard Kaiko, Doctor Jay Horvat, Doctor Simon Keely, Doctor Andrew Jarnicki, Doctor Michael Fricker
SchemeEquipment Grant
RoleInvestigator
Funding Start2013
Funding Finish2013
GNoG1201186
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

Thoracic Society of Australia and New Zealand$1,675

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding bodyUniversity of Newcastle - Faculty of Health and Medicine
Project TeamDoctor Katie Baines
SchemeTravel Grant
RoleLead
Funding Start2013
Funding Finish2013
GNoG1300405
Type Of FundingInternal
CategoryINTE
UONY

20125 grants / $435,832

2011 Research Fellowship - PRCARD$333,302

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Katie Baines
SchemeResearch Fellowship
RoleLead
Funding Start2012
Funding Finish2012
GNoG1200356
Type Of FundingInternal
CategoryINTE
UONY

Phenotype based management of severe persistent asthma$34,454

Funding body: John Hunter Hospital Charitable Trust Fund

Funding bodyJohn Hunter Hospital Charitable Trust Fund
Project TeamAssociate Professor Vanessa McDonald, Doctor Katie Baines, Conjoint Professor Peter Gibson
SchemeResearch Grant
RoleInvestigator
Funding Start2012
Funding Finish2012
GNoG1200211
Type Of FundingOther Public Sector - State
Category2OPS
UONY

Body plethysmograph respiratory function system$33,076

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamConjoint Professor Peter Gibson, Conjoint Professor Peter Wark, Associate Professor Lisa Wood, Associate Professor Jodie Simpson, Doctor Katie Baines, Doctor Vanessa Murphy, Doctor Jeffrey Pretto, Emeritus Professor Michael Hensley, Ms Jenny Mackney
SchemeEquipment Grant
RoleInvestigator
Funding Start2012
Funding Finish2012
GNoG1100973
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

Phenotype based management of severe persistent asthma$20,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamAssociate Professor Vanessa McDonald, Doctor Katie Baines, Conjoint Professor Peter Gibson
SchemeResearch Grant
RoleInvestigator
Funding Start2012
Funding Finish2012
GNoG1101169
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Gene expression markers, mechanisms and steroid response of neutrophilic asthma$15,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Katie Baines
SchemeFellowship Grant
RoleLead
Funding Start2012
Funding Finish2012
GNoG1200082
Type Of FundingInternal
CategoryINTE
UONY

20117 grants / $92,989

Transcriptional Phenotyping of COPD and the relationship between neutrophilic airway inflammation, airway infection and activation of proinflammatory pathways$24,000

Funding body: John Hunter Hospital Charitable Trust Fund

Funding bodyJohn Hunter Hospital Charitable Trust Fund
Project TeamDoctor Katie Baines, Conjoint Professor Peter Gibson, Associate Professor Jodie Simpson
SchemeResearch Grant
RoleLead
Funding Start2011
Funding Finish2011
GNoG1100635
Type Of FundingOther Public Sector - State
Category2OPS
UONY

Identification of a specific biomarker signature that identifies asthma phenotype $23,700

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Katie Baines, Associate Professor Jodie Simpson, Conjoint Professor Peter Gibson
SchemeProject Grant
RoleLead
Funding Start2011
Funding Finish2011
GNoG1001054
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Transcriptional Phenotyping of COPD and the relationship between neutrophilic airway inflammation, airway infection and activation of proinflammatory pathways$20,000

Funding body: Australian Lung Foundation

Funding bodyAustralian Lung Foundation
Project TeamDoctor Katie Baines
SchemeGrant-In-Aid for New and Emerging Researchers
RoleLead
Funding Start2011
Funding Finish2011
GNoG1000976
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

Epigenetic changes in infants associated with maternal asthma during pregnancy$10,000

Funding body: Thoracic Society of Australia and New Zealand

Funding bodyThoracic Society of Australia and New Zealand
Project TeamDoctor Katie Baines
SchemeGrant-in-aid (supported by Merck Sharp & Dohme)
RoleLead
Funding Start2011
Funding Finish2011
GNoG1000991
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

Lung Function (Spirometry) testing and sputum induction equipment - establishing 3 new clinical workstations. Medgraphics CPFS/d USB spirometer with breezesuite software (x3). Laptop computer (x3). Ul$10,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamConjoint Professor Peter Gibson, Associate Professor Jodie Simpson, Associate Professor Lisa Wood, Doctor Katie Baines, Conjoint Professor Peter Wark, Doctor Vanessa Murphy
SchemeEquipment Grant
RoleInvestigator
Funding Start2011
Funding Finish2011
GNoG1100038
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

PULSE Education Prize$4,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Katie Baines
SchemePULSE Education Prize
RoleLead
Funding Start2011
Funding Finish2011
GNoG1100342
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Thoracic Society of Australia and New Zealand, Perth Convention and Exhibition Centre, 2 - 6 April 2011$1,289

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding bodyUniversity of Newcastle - Faculty of Health and Medicine
Project TeamDoctor Katie Baines
SchemeTravel Grant
RoleLead
Funding Start2011
Funding Finish2011
GNoG1100297
Type Of FundingInternal
CategoryINTE
UONY

20101 grants / $34,000

Real time PCR machine (Mastercycler ep realplex2 from Epprndorf) $34,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamAssociate Professor Jodie Simpson, Conjoint Professor Peter Gibson, Conjoint Professor Peter Wark, Associate Professor Lisa Wood, Doctor Vanessa Murphy, Doctor Robert Scott, Doctor Katie Baines
SchemeEquipment Grant
RoleInvestigator
Funding Start2010
Funding Finish2010
GNoG1000056
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

20091 grants / $63,354

Epigenetic regulation of airways inflammation in non-eosinophilic asthma$63,354

Funding body: Asthma Foundation of New South Wales

Funding bodyAsthma Foundation of New South Wales
Project TeamConjoint Professor Peter Gibson, Doctor Katie Baines, Associate Professor Jodie Simpson
SchemePhD Scholarships
RoleInvestigator
Funding Start2009
Funding Finish2009
GNoG0189748
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

20083 grants / $311,655

Molecular mechanisms and treatment of non-eosinophilic asthma$300,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamAssociate Professor Jodie Simpson, Doctor Katie Baines
SchemeProject Grant
RoleInvestigator
Funding Start2008
Funding Finish2008
GNoG0188825
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Molecular subtypes of asthma defined by gene expression profiling$9,955

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Katie Baines
SchemeEarly Career Researcher Grant
RoleLead
Funding Start2008
Funding Finish2008
GNoG0189618
Type Of FundingInternal
CategoryINTE
UONY

American Thoracic Society, Metro Toronto Convention Centre, 16/5/2008 - 21/5/2008$1,700

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Katie Baines
SchemeTravel Grant
RoleLead
Funding Start2008
Funding Finish2008
GNoG0188599
Type Of FundingInternal
CategoryINTE
UONY

20061 grants / $18,837

Molecular Pathogenesis of Non-Eosinophilic Asthma$18,837

Funding body: Asthma Foundation of New South Wales

Funding bodyAsthma Foundation of New South Wales
Project TeamDoctor Katie Baines, Conjoint Professor Peter Gibson
SchemePhD Scholarships
RoleLead
Funding Start2006
Funding Finish2006
GNoG0185985
Type Of FundingDonation - Aust Non Government
Category3AFD
UONY

20041 grants / $37,837

Molecular Pathogensis of Non-Eosinphilic Asthma$37,837

Funding body: Asthma Foundation of New South Wales

Funding bodyAsthma Foundation of New South Wales
Project TeamConjoint Professor Peter Gibson, Professor Rodney Scott, Doctor Katie Baines
SchemePhD Scholarships
RoleInvestigator
Funding Start2004
Funding Finish2004
GNoG0183715
Type Of FundingDonation - Aust Non Government
Category3AFD
UONY
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Research Supervision

Current Supervision

CommencedResearch Title / Program / Supervisor Type
2015Dietary Fibre As A Modulator of Inflammation In Asthma
Medical Science, Faculty of Health and Medicine
Co-Supervisor
2015Fruit and Vegetable Extract for the Reduction of Obesity-Induced Inflammation
Medical Science, Faculty of Health and Medicine
Co-Supervisor
2014The Effects of Galectin-3 on Alveolar Macrophage Function in Asthma
General Medicine, Faculty of Health and Medicine
Co-Supervisor
2013The Role of Comorbidities and Inflammation in COPD
General Medicine, Faculty of Health and Medicine
Co-Supervisor
2012Fatty Acids and the Innate Immune Response
Medical Science, Faculty of Health and Medicine
Co-Supervisor

Past Supervision

YearResearch Title / Program / Supervisor Type
2014Epigenetic Regulation of Airway Inflammation in Asthma
General Medicine, Faculty of Health and Medicine
Co-Supervisor
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News

New study to examine fibre effect on asthma

June 15, 2015

Respiratory researchers from the University of Newcastle and HMRI are looking into whether a high-fibre diet can reduce airway inflammation in people with asthma.

Associate Professor Lisa Wood

Fruit-and-veg capsule set to combat obesity impacts

March 24, 2014

Hunter Medical Research Institute researchers are examining whether a simple fruit-and-vegetable supplement, taken in capsule form, can reduce inflammation produced by fat cells and thereby lower the risk of heart disease, diabetes, asthma and cancers in overweight people.

Dr Katie Baines

Position

Postdoctoral Research Fellow
Respiratory Medicine
School of Medicine and Public Health
Faculty of Health and Medicine

Contact Details

Emailkatherine.baines@newcastle.edu.au
Phone(02) 40420090
Fax(02) 40420046

Office

RoomRoom 2109 Level 2 West Wing
BuildingHunter Medical Research Institute
LocationHMRI Building

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