Dr Karen Kerr

Senior Lecturer

School of Biomedical Sciences and Pharmacy (Pharmacy and Experimental Pharmacology)

Career Summary

Biography

Background - PhD in Pharmacology and Diploma in Pharmacy.

Research Expertise
A range of methods including organ bath studies, live cell imaging, immunohistochemistry and electrophysiology are used to elucidate the various cell signaling pathways that contribute to the contractility of the mouse myometrium in response to various autacoids, neurotransmitters and hormones. We have several projects that study possible factors affecting premature birth which remains a major unsolved problem that affects some 15% of births internationally and is increasing in incidence.

Collaborations
Pharmacology of the pelvic organs (uterus, bladder and prostate) with a focus on cell signaling mechanisms understanding mechanisms that may affect uterine motility urinary incontinence and benign prostatic hyperplasia. Techniques used include functional studies (organ bath work) and immunohistochemistry.


Qualifications

  • PhD, Monash University
  • Bachelor of Science, Rhodes University
  • Diploma in Pharmacy, Technikon Witwatersrand - South Africa
  • Bachelor of Science (Honours), University of Witwatersrand

Keywords

  • Pharmaceutical Sciences
  • Pharmacology

Fields of Research

Code Description Percentage
110399 Clinical Sciences not elsewhere classified 20
111699 Medical Physiology not elsewhere classified 20
111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified 60

Professional Experience

UON Appointment

Title Organisation / Department
Senior Lecturer University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia

Invitations

Speaker

Year Title / Rationale
2010 Dr Karen Kerr
Organisation: Bond University, Gold Coast, QLD, Description: Invited to give a talk on 'Interstitial cells of Cajal in the mouse reproductive tract' at the 2nd National Symposium on Advances in Gastrointestinal & Urogenital Research, Bond University, Gold Coast, QLD, Sept 3rd (2010).
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Chapter (1 outputs)

Year Citation Altmetrics Link
2007 Candenas ML, Pennefather JN, Kerr KP, Perez-Hernandez N, Pinto FM, 'Tachykinins and smooth muscle function', New Frontiers in Smooth Muscle Biology and Physiology, Transworld Research Network, Kerala, India 383-411 (2007) [B1]

Journal article (10 outputs)

Year Citation Altmetrics Link
2015 Mate KE, Kerr KP, Pond D, Williams EJ, Marley J, Disler P, et al., 'Impact of multiple low-level anticholinergic medications on anticholinergic load of community-dwelling elderly with and without dementia.', Drugs Aging, 32 159-167 (2015)
DOI 10.1007/s40266-014-0230-0
Co-authors Karen Mate, Dimity Pond, Parker Magin
2014 Gravina FS, Van Helden DF, Kerr KP, De Oliveira RB, Jobling P, 'Phasic contractions of the mouse vagina and cervix at different phases of the estrus cycle and during late pregnancy', PLoS ONE, 9 (2014) [C1]

Conclusions/Significance: Cervical smooth muscle strips taken from mice in estrus, metestrus or late pregnancy were generally spontaneously active. Vaginal smooth muscle strips we... [more]

Conclusions/Significance: Cervical smooth muscle strips taken from mice in estrus, metestrus or late pregnancy were generally spontaneously active. Vaginal smooth muscle strips were normally quiescent but could be induced to exhibit phasic contractions independent on phase of the estrus cycle or late pregnancy. Spontaneous cervical or TEA-induced vaginal phasic contractions were not mediated by ICs or intracellular Ca2+ stores. Given that vaginal smooth muscle is normally quiescent then it is likely that increases in hormones such as oxytocin, as might occur through sexual stimulation, enhance the effectiveness of such pacemaking until phasic contractile activity emerges.

DOI 10.1371/journal.pone.0111307
Citations Scopus - 2Web of Science - 3
Co-authors Phillip Jobling, Dirk Vanhelden
2014 Kerr KP, Mate KE, Magin PJ, Marley J, Stocks NP, Disler P, Pond CD, 'The prevalence of co-prescription of clinically relevant CYP enzyme inhibitor and substrate drugs in community-dwelling elderly Australians', JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, 39 383-389 (2014) [C1]
DOI 10.1111/jcpt.12163
Citations Scopus - 1Web of Science - 1
Co-authors Karen Mate, Parker Magin, Dimity Pond
2013 Lam M, Kerr KP, Exintaris B, 'Involvement of Rho-Kinase Signaling Pathways in Nerve Evoked and Spontaneous Contractions of the Guinea Pig Prostate', JOURNAL OF UROLOGY, 189 1147-1154 (2013) [C1]
DOI 10.1016/j.juro.2012.08.220
Citations Scopus - 2Web of Science - 2
2011 Lam M, Kerr KP, Ventura S, Exintaris B, 'Extracellular Ca2+ entry and mobilization of inositol trisphosphate-dependent Ca2+ stores modulate histamine and electrical field stimulation induced contractions of the guinea-pig prostate', Pharmacological Research, 64 235-241 (2011) [C1]
DOI 10.1016/j.phrs.2011.04.009
2011 Gravina FS, Jobling P, Kerr KP, De Oliveira R, Parkington HC, Van Helden DF, 'Oxytocin depolarizes mitochondria in isolated myometrial cells', Experimental Physiology, 96 949-956 (2011) [C1]
DOI 10.1113/expphysiol.2011.058388
Citations Scopus - 1Web of Science - 1
Co-authors Phillip Jobling, Dirk Vanhelden
2010 Gravina FS, Parkington HC, Kerr KP, De Oliveira R, Jobling P, Coleman HA, et al., 'Role of mitochondria in contraction and pacemaking in the mouse uterus', British Journal of Pharmacology, 161 1375-1390 (2010) [C1]
DOI 10.1111/j.1476-5381.2010.00949.x
Citations Scopus - 7Web of Science - 7
Co-authors Phillip Jobling, Dirk Vanhelden
2008 Patak E, Pennefather JN, Gozali M, Candenas L, Kerr K, Exintaris B, et al., 'Functional characterisation of hemokinin-1 in mouse uterus', European Journal of Pharmacology, 601 148-153 (2008) [C1]
DOI 10.1016/j.ejphar.2008.10.036
Citations Scopus - 7Web of Science - 6
2007 Chetty N, Coupar IM, Chess-Williams R, Kerr KP, 'Demonstration of 5-HT3 receptor function and expression in the mouse bladder', Naunyn-Schmiedebergs Archives of Pharmacology, 375 359-368 (2007) [C1]
DOI 10.1007/s00210-007-0173-7
2006 Kerr KP, 'The effect of histamine on field-stimulated contractions of the guinea-pig prostate', Naunyn-Schmiedebergs Archives of Pharmacology, 373 237-244 (2006) [C1]
DOI 10.1007/s00210-006-0061-6
Show 7 more journal articles

Conference (15 outputs)

Year Citation Altmetrics Link
2014 Kerr KP, Mate KE, Williams E, Pond D, Magin PJ, 'Factors associated with a high anticholinergic burden in elderly Australians with and without dementia', ASCEPT-MPGPCR Joint Scientific Meeting, Melbourne (2014) [E3]
Co-authors Parker Magin, Dimity Pond, Karen Mate
2013 Kerr KP, Mate KE, Williams E, Pond D, Magin PJ, 'Anticholinergic load in community dwelling elderly Australians with dementia', ASCEPT Annual Scientific Meeting, Melbourne, Vic (2013) [E3]
Co-authors Dimity Pond, Karen Mate, Parker Magin
2012 Mate KE, Kerr KP, Pond CD, Magin PJ, 'Potentially inappropriate medications in the elderly - A case study', Symposium Program. Interprofessional Education for Quality Use of Medicines, Newcastle Beach, NSW (2012) [E3]
Co-authors Karen Mate, Parker Magin, Dimity Pond
2012 Kerr KP, Mate KE, Pond CD, Magin PJ, 'An ACE inhibitor and a Sartan - Is there a place for this combination? A real-life case study for students in the health professions', Symposium Program. Interprofessional Education for Quality Use of Medicines, Newcastle Beach, NSW (2012) [E3]
Co-authors Parker Magin, Dimity Pond, Karen Mate
2012 Kerr KP, Mate KE, Pond CD, Magin PJ, Stocks N, Marley JE, Disler P, 'Prescribing in the elderly - cytochrome P450 (CYP) enzyme inhibitors and substrates', ASCEPT-APSA 2012 Oral Abstracts, Sydney, NSW (2012) [E3]
Co-authors Parker Magin, Dimity Pond, Karen Mate
2010 Gravina FS, Van Helden DF, De Oliveira R, Kerr KP, Jobling P, 'Relaxant effects of methanandamide unmasked by indomethacin in the mouse uterus', Australasian Society of Clinical and Experimental Pharmacology and Toxicology (ASCEPT) Annual Scientific Meeting, Melbourne, 2010, Melbourne, Vic (2010) [E3]
Co-authors Phillip Jobling, Dirk Vanhelden
2009 Gravina FS, Kerr KP, Sandow S, De Oliveira R, Parkington H, Imtiaz MS, Van Helden DF, 'Intracellular calcium stores in mouse uterus: SR and Mitochondria', Journal of Physiological Sciences, Kyoto, Japan (2009) [E3]
Co-authors Dirk Vanhelden
2009 Lam MH-S, Kerr KP, Exintaris B, 'Investigation of internal Ca2+ release in spontaneous electrical activity and histamine-induced contractions in the guinea-pig prostate', Proceedings of the XXXVI International Congress of Physiological Sciences (IUPS2009) Function of Life: Elements and Integration, Kyoto, Japan (2009) [E3]
2009 Gravina FS, Jobling P, Kerr KP, De Oliveira R, Van Helden DF, 'Identification of cannabinoid receptor 1 and the effect of methanandamide on uterine contractions of the mouse uterus', 1st National Symposium on Advances in Urogenital and Gut Research, Melbourne, VIC (2009) [E3]
Co-authors Phillip Jobling, Dirk Vanhelden
2009 Hollins SL, Johnstone DM, Graham R, Van Helden DF, Kerr KP, Laver DR, et al., 'Cardiac gene expression in mouse models of iron loading disorders', 2009 International Biolron Society Meeting: Program Book, Porto, Portugal (2009) [E3]
Co-authors Dirk Vanhelden, Liz Milward, Rodney Scott, Derek Laver
2009 Kerr KP, Jobling P, Gravina FS, Van Helden DF, 'Contractility of the lower uterus and upper vagina in the mouse', 43rd ASCEPT Annual Scientific Meeting: Proceedings, Sydney, NSW (2009) [E3]
Co-authors Dirk Vanhelden, Phillip Jobling
2009 Hollins SL, Johnstone DM, Van Helden DF, Kerr KP, Laver DR, Metelerkamp KM, et al., 'Cardiac gene expression in mouse models of iron loading', ASMR XVII NSW Scientific Meeting: Programme and Abstracts, Sydney, NSW (2009) [E3]
Co-authors Dirk Vanhelden, Liz Milward, Derek Laver, Rodney Scott
2008 Lam MH, Kerr KP, Exintaris B, 'Investigation of internal Ca2+ store release through histamine and phenylephrine-induced contractions in the guinea-pig prostate', Proceedings of the Australian Health and Medical Research Congress 2008, Brisbane, QLD (2008) [E3]
2008 Gravina FS, Kerr KP, De Oliveira R, Parkington H, Imtiaz MS, Van Helden DF, 'Effects of the mitochondrial inhibitors CCCP, rotenone and CGP37157 on spontaneous contractions in the mouse uterus', Proceedings of the Australian Health and Medical Research Congress 2008, Brisbane, QLD (2008) [E3]
Co-authors Dirk Vanhelden
2008 Gravina FS, Kerr KP, Sandow S, De Oliveira R, Parkington HC, Imtiaz MS, Van Helden DF, 'Uterine spontaneous contractions in the estrous cycle and the effect of mitochondrial inhibitors', Proceedings of the Australian Physiological Society, Melbourne, VIC (2008) [E3]
Co-authors Dirk Vanhelden
Show 12 more conferences
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Grants and Funding

Summary

Number of grants 3
Total funding $3,339

Click on a grant title below to expand the full details for that specific grant.


20151 grants / $1,500

Joint Scientific Meeting, Hong Kong China, 19-21 May 2015$1,500

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Doctor Karen Kerr
Scheme Travel Grant
Role Lead
Funding Start 2015
Funding Finish 2016
GNo G1500286
Type Of Funding Internal
Category INTE
UON Y

20131 grants / $999

ASCEPT Annual Scientific Meeting (Australasian Society of Clinical and Experimental Pharmacologist and Toxicologists), Melbourne Australia, 1-4 December 2013$999

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Doctor Karen Kerr
Scheme Travel Grant
Role Lead
Funding Start 2013
Funding Finish 2013
GNo G1301095
Type Of Funding Internal
Category INTE
UON Y

20121 grants / $840

Joint ASCEPT - APSA Conference - Medication and Safety, Sydney Convention and Exhibition Centre, 2 - 5 December 2012$840

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Doctor Karen Kerr
Scheme Travel Grant
Role Lead
Funding Start 2012
Funding Finish 2012
GNo G1201070
Type Of Funding Internal
Category INTE
UON Y
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Research Supervision

Current Supervision

Commenced Research Title / Program / Supervisor Type
2014 The Effects of Iron Dysregulation on the Heart, Lungs and Reproductive System
Health, Faculty of Health and Medicine
Co-Supervisor
2014 Strategies for Introducing Personalised Healthcare and Pharmacogenomics into Community Pharmacies.
Pharmacy, Faculty of Health and Medicine
Co-Supervisor
2013 The Feasibility and Value of Holistic Systems-Based Approaches to Personalised, Patient-Centred Healthcare in Modern Pharmacy
Health, Faculty of Health and Medicine
Co-Supervisor

Past Supervision

Year Research Title / Program / Supervisor Type
2011 Contractile Properties of the Female Reproductive Tract
Human Biology, Faculty of Health and Medicine
Co-Supervisor
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Dr Karen Kerr

Position

Senior Lecturer
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

Focus area

Pharmacy and Experimental Pharmacology

Contact Details

Email karen.kerr@newcastle.edu.au
Phone (02) 4921 6572
Mobile 0423788656
Fax (02) 4921 7903

Office

Room MS125
Building Medical Sciences
Location Callaghan
University Drive
Callaghan, NSW 2308
Australia
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