Ms Joyce Cooper

Ms Joyce Cooper

Lecturer

School of Biomedical Sciences and Pharmacy (Pharmacy and Experimental Pharmacology)

Career Summary

Biography

Research Expertise
My research has involved investigating factors contributing to serotonin toxicity. Areas include the pharmacogenomics of serotonin toxicity, particularly investigating the role of the serotonin receptor gene. Additionally, I have also examined the pharmacokinetics of sertraline (a selective serotonin reuptake inhibitor antidepressant) in overdose and the administration of activated charcoal in treatment using population pharmacokinetic modelling techniques with Monolix software. A third study has involved the use of the non mixed effects model (NONMEM) software to perform a logistic regression to examine factors that contribute to serotonin toxicity in patients who have taken an overdose of antidepressant drugs. This includes factors such as dose, age, gender, additional medications as well as the type of antidepressant medication. I also have a strong research interest in areas of teaching and learning. In 2012 I led a group which was awarded a UON Teaching and Learning grant, and developed "The Virtual Pharmacy". After evaluation and fine tuning, this is now a successful online resource used in the teaching of the Master of Pharmacy Program at the university. (Available at: http://virtualpharmacy.newcastle.edu.au/ ) In 2013, a further successful Teaching and Learning grant (UON) has led to the development of "Virtual Drugs" - an online library of drug images, audio and prescriptions. We are currently researching the usability and impact of these recent innovations to student learning. Simulation in teaching and learning is another area where I have been involved, particularly in pharmacy practice. In 2012 I was part of a group which investigated using trained actors as simulated patients in oral communication skills teaching and assessment. I remain a registered pharmacist and continue to be involved in clinical research in both the hospital and community pharmacy settings.

Qualifications

  • Graduate Diploma in Clinical Pharmacy, University of Queensland
  • Bachelor of Science (Pharmacy), University of Sunderland - United Kingdom
  • Graduate Certificate Practice of Tertiary Teaching, University of Newcastle

Keywords

  • Serotonin toxicity
  • clinical pharmacy
  • pharmacogenomics
  • pharmacy practice
  • population PK-PD modelling
  • toxicology

Fields of Research

Code Description Percentage
080110 Simulation and Modelling 20
111503 Clinical Pharmacy and Pharmacy Practice 30
111506 Toxicology (incl. Clinical Toxicology) 50

Professional Experience

UON Appointment

Title Organisation / Department
Lecturer University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia

Membership

Dates Title Organisation / Department
1/01/2013 -  Membership - The Royal Pharmaceutical Society of Great Britain The Royal Pharmaceutical Society of Great Britain
Australia
1/01/2005 -  Membership - The Society of Hospital Pharmacists of Australia The Society of Hospital Pharmacists of Australia
Australia
1/01/1989 -  Membership - AHPRA AHPRA
Australia
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Journal article (8 outputs)

Year Citation Altmetrics Link
2015 Michael AP, Mostafa A, Cooper JM, Grice J, Roberts MS, Isbister GK, 'Erratum: The pharmacokinetics and pharmacodynamics of severe aldicarb toxicity after overdose (Clinical Toxicology (2015) (1-3))', Clinical Toxicology, 53 788 (2015) [O1]
DOI 10.3109/15563650.2015.1063280
Co-authors Geoff Isbister
2015 Cooper JM, Duffull SB, Saiao AS, Isbister GK, 'The pharmacokinetics of sertraline in overdose and the effect of activated charcoal', British Journal of Clinical Pharmacology, 79 307-315 (2015) [C1]

Aims To investigate the pharmacokinetics (PK) of sertraline in overdose and the effect of single dose activated charcoal (SDAC). Methods Patients presenting to a toxicology unit w... [more]

Aims To investigate the pharmacokinetics (PK) of sertraline in overdose and the effect of single dose activated charcoal (SDAC). Methods Patients presenting to a toxicology unit with sertraline overdoses had demographic and clinical information recorded, and serial serum collected for measurement of sertraline concentrations. Monolix® version 4.2 was used to develop a population PK model of sertraline overdose and the effect of SDAC. Uncertainty in dose time was accounted for by shifting dose time using lag time with between subject variability (BSV). BSV on relative fraction absorbed was used to model uncertainty in dose. Results There were 77 timed sertraline concentrations measured in 28 patients with sertraline overdoses with a median dose of 1550 mg (250-5000 mg). SDAC was given to seven patients between 1.5 and 4 h post-overdose. A one compartment model with lag time of 1 h and first order input and elimination adequately described the data. Including BSV on both lag time and relative fraction absorbed improved the model. The population PK parameter estimates for absorption rate constant, volume of distribution and clearance were 0.895 h-1, 5340 l and 130 l h-1, respectively. The calculated half-life of sertraline following overdose was 28 h (IQR 19.4-30.6h). When given up to 4 h post-overdose, SDAC significantly increased the clearance of sertraline by a factor of 1.9, decreased the area under the curve and decreased the maximum plasma concentration (Cmax). Conclusions Sertraline had linear kinetics in overdose with parameter values similar to those in therapeutic use. SDAC is effective in increasing clearance when given 1.5 to 4 h post-overdose.

DOI 10.1111/bcp.12500
Citations Scopus - 1Web of Science - 1
Co-authors Geoff Isbister
2015 Michael AP, Mostafa A, Cooper JM, Grice J, Roberts MS, Isbister GK, 'The pharmacokinetics and pharmacodynamics of severe aldicarb toxicity after overdose', Clinical Toxicology, 53 633-635 (2015) [C1]

© 2015 Informa Healthcare USA, Inc. Objective. To describe the clinical effects, pharmacokinetics, and pharmacodynamics of plasma and acetylcholinesterase in an aldicarb overdose... [more]

© 2015 Informa Healthcare USA, Inc. Objective. To describe the clinical effects, pharmacokinetics, and pharmacodynamics of plasma and acetylcholinesterase in an aldicarb overdose. Case Report. A 57-year-old female was found unconscious and incontinent of urine after ingesting aldicarb. She was bradycardic, hypotensive, hypersalivating, clammy, had small pupils, and generalized weakness. She was intubated, ventilated, and treated with large atropine doses (50 mg and 20 mg/h infusion) and adrenaline. She improved hemodynamically over 24 h, but remained comatose for another 24 h, before recovering without sequela. Aldicarb concentration at admission was 2.18 µg/ml and concentration-time data best fitted a two compartmental model with first order absorption and a time of ingestion 4.5 h preadmission. The half-life of distribution was 0.4 h and half-life of elimination, 13 h. Plasma cholinesterase concentration at admission was 0.3 kU/L (Reference range[RR]:4.3-10.6 kU/L) and red cell cholinesterase was 10 U/gHb (RR:38-66 U/gHb). The IC50 was 0.15 µg/ml and 0.26 µg/ml for plasma and red cell cholinesterase, respectively. Discussion. Aldicarb poisoning causes rapid onset severe toxicity with muscarinic and nicotinic excess, seizures, and decreased consciousness. Cholinesterases rapidly recover once aldicarb concentrations decrease and precede clinical recovery.

DOI 10.3109/15563650.2015.1054504
Co-authors Geoff Isbister
2014 Cooper J, Garrett T, 'Providing medicines information and education to hospital in-patients: patients¿ experiences and preferences', Journal of Pharmacy Practice and Research, 44 213-219 (2014) [C1]
2014 Cooper JM, Newby DA, Whyte IM, Carter G, Jones AL, Isbister GK, 'Serotonin toxicity from antidepressant overdose and its association with the T102C polymorphism of the 5-HT receptor', Pharmacogenomics J, (2014) [C1]
DOI 10.1038/tpj.2013.47
Citations Scopus - 1
Co-authors David Newby, Gregory Carter, Geoff Isbister
2014 Cooper J, Hookham G, Nesbitt KV, Rasiah RL, 'Developing a Virtual Tour of a Community Pharmacy for use in Education', IT in Industry, 2 33-37 (2014) [C1]
Co-authors Keith Nesbitt, Rohan Rasiah
2011 Gilligan C, Outram S, Rasiah RL, Cooper J, 'Exploring the attitudes of pharmacy students to clinical communications training', Focus on Health Professional Education, 13 25-36 (2011) [C1]
Co-authors Sue Outram, Rohan Rasiah, Conor Gilligan
2009 Cooper J, Jones AL, 'Neuroleptic malignant syndrome or a statin drug reaction? A case report', Clinical Neuropharmacology, 32 348-349 (2009) [C3]
DOI 10.1097/wnf.0b013e3181acc92d
Citations Scopus - 4Web of Science - 4
Show 5 more journal articles

Conference (11 outputs)

Year Citation Altmetrics Link
2015 Hookham G, Nesbitt K, Cooper J, Croft H, Rasiah R, 'Gamification for education: Designing a pharmacy education game', Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) (2015)

© Springer International Publishing Switzerland 2015. A key motivator for the use of serious games has been the notion that ¿gamification¿ provides users with an additional lev... [more]

© Springer International Publishing Switzerland 2015. A key motivator for the use of serious games has been the notion that ¿gamification¿ provides users with an additional level of engagement. This study examines a traditional model of usability in terms of engagement and efficacy, presenting the results obtained from a formative evaluation of a serious game prototype that has been developed to assist in pharmacy education.

Citations Scopus - 1
Co-authors Rohan Rasiah, Keith Nesbitt
2015 Coooper JM, Isbister GK, 'Desvenlafaxine overdose and the incidence of serotonin toxicity, seizures and cardiovascular effects', CLINICAL TOXICOLOGY (2015) [E3]
Co-authors Geoff Isbister
2014 Cooper J, Duffull SB, Saiao AS, Isbister GK, 'The effect of single-dose activated charcoal following sertraline overdose', The 40th SHPA National Conference: Book of Abstracts (2014) [E3]
Co-authors Geoff Isbister
2014 Croft H, Rasiah R, Cooper J, Nesbitt K, 'Comparing Animation with Video For Teaching Communication Skills', Proceedings of the 2014 Conference on Interactive Entertainment (2014) [E1]
DOI 10.1145/2677758.2677777
Co-authors Keith Nesbitt, Rohan Rasiah
2014 Hookham G, Cooper J, Rasiah R, Croft H, Nesbitt K, 'Efficacy and Usability in the Design of a Pharmacy Education Game', ENTERTAINMENT COMPUTING - ICEC 2014 (2014) [E3]
Co-authors Rohan Rasiah, Keith Nesbitt
2014 Chalmers L, Nash R, Holmes S, Bereznicki L, Rasiah RL, Cooper JM, et al., 'Development of a benchmarking tool for pharmacy students using threshold learning outcomes' (2014)
2013 Cooper JM, 'Personalised Medicine: Predicting Serotonin Toxicity from Pharmacogenetic Studies', Final program and conference proceedings (2013) [E3]
2012 Cooper J, Garrett T, 'Providing medicines information - The experience of hospital patients', Final Program and Abstract Book. National Medicines Symposium 2012 (2012) [E3]
2010 Cooper J, Gilligan C, Outram S, Rasiah RL, 'Communication skills training in health programs at the University of Newcastle, Australia', International Conference on Communication in Healthcare 2010 (2010) [E3]
Co-authors Conor Gilligan, Rohan Rasiah, Sue Outram
2009 Cooper J, Jones AL, 'Antipsychotic induced neuroleptic malignant syndrome: Or a simple drug interaction?', Across the Divide: Medicines Management 2009, The 35th SHPA National Conference: Abstracts, Posters (2009) [E3]
2008 Cooper J, Pillay RD, Fung NK, Barry DA, Schwagger M, Inglis D, 'Getting to the bottom of it: Give a laxative with the opioid!', Medicines Management 2008: The 34th SHPA National Conference: Conference Handbook (2008) [E3]
Show 8 more conferences

Creative Work (1 outputs)

Year Citation Altmetrics Link
2013 Croft H, Nesbitt KV, Rasiah R, Cooper J, Arrighi G, Joyce B, McGuire B, Communication Scenario: Over the Counter Dispensing of the Emergency Contraceptive Pill (Video and Animation - in 3 parts), Newcastle, NSW, Australia (2013) [J2]
Co-authors Keith Nesbitt, Gillian Arrighi, Rohan Rasiah

Other (1 outputs)

Year Citation Altmetrics Link
2014 Cooper JM, Duffull SB, Saiao AS, Isbister GK, 'The effect of activated charcoal on the pharmacokinetics of sertraline in overdose', ( pp.1): Conference Proceedings (2014) [O1]
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Grants and Funding

Summary

Number of grants 3
Total funding $14,169

Click on a grant title below to expand the full details for that specific grant.


20122 grants / $13,399

Evidence-based community pharmacy practice: the use of evidence in selecting over-the-counter medicines$12,264

Funding body: Pharmacy Research Trust of NSW

Funding body Pharmacy Research Trust of NSW
Project Team Associate Professor David Newby, Ms Joyce Cooper, Doctor Jane Robertson, Ms Yee Ching Ng, Mr Marc Bevan
Scheme Research Grant
Role Investigator
Funding Start 2012
Funding Finish 2012
GNo G1101183
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

National medicines Symposium, Sydney, 24 - 25 May 2012$1,135

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Ms Joyce Cooper
Scheme Travel Grant
Role Lead
Funding Start 2012
Funding Finish 2012
GNo G1200539
Type Of Funding Internal
Category INTE
UON Y

20081 grants / $770

Medicines Management 2008 - SHPA (Society of hospital pharmacists of Australia) National Conference, Adelaide Convention Centre, 4/9/2008 - 6/9/2008$770

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Ms Joyce Cooper
Scheme Travel Grant
Role Lead
Funding Start 2008
Funding Finish 2008
GNo G0189369
Type Of Funding Internal
Category INTE
UON Y
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Ms Joyce Cooper

Position

Lecturer
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

Focus area

Pharmacy and Experimental Pharmacology

Contact Details

Email joyce.cooper@newcastle.edu.au
Phone (02) 4921 2023
Fax (02) 4921 7903

Office

Room MS115
Building Medical Sciences
Location Callaghan
University Drive
Callaghan, NSW 2308
Australia
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