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Professor Jon Hirst

Professor

School of Biomedical Sciences and Pharmacy (Pharmacy and Experimental Pharmacology)

Career Summary

Biography

I work both in the School of Biomedical Sciences and Pharmacy Medical Sciences Building and at the Mothers and Babies Research Centre, JHH campus. We are also part of Hunter Medical Research Institute and strongly support the activities of HMRI. Research activities: Since moving to Newcastle in 2005, I have developed research programme examining the effects of stressors on neurosteroid production during pregnancy and at the fetal to neonatal transition. The overall goal of this work is to develop neurosteroid replacement strategies for reducing neonatal brain injury. Our team 7 staff and students including 3 PhD students. We have major joint projects within the Mothers and Babies Research Centre with Associate Professor Zakar, continuing my long standing interest in prevention of preterm labour. We also work with Professor E Lumbers, FAA, in a major collaboration with her that will examine the role of the uterine prorenin/renin receptor system in the control of cyclooxygenase-2 (COX-2) levels at labour onset. Teaching work: I coordinate 3 pharmacology courses per year in the B. Biomedical Science and Master of Pharmacy programmes. One course is delivered entirely online and attracts students from around the country that are interested in gaining a pharmacology qualification.

Research Expertise
Topics include fetal and neonatal physiology. Endocrinology of pregnancy, birth and preterm labour. Animal models in pregnancy research. Improved therapies for the treatment of preterm labour.

Teaching Expertise
Phamarcology with particular knowledge of reproduction and pregnancy. pharamcology and the endocrine system, sex hormones and HRT. Endocrine and reproductive physiology.

Administrative Expertise
Course co-oridinatior 3 courses (2006& 2007 in Pharmacy and Biomed Sci. programmes. Member of the NH&MRC grant review panel. Member of the PSANZ abstract and student prize panels. Member of the Animal Ethics committee.



Qualifications

  • PhD (Physiology), Monash University
  • Bachelor of Science (Honours), University of Adelaide

Keywords

  • Endocrinology
  • Fetal Physiology
  • Neuroendocrinology
  • Pharmacology
  • Pregnancy
  • Preterm labour
  • Reproduction

Fields of Research

Code Description Percentage
111499 Paediatrics and Reproductive Medicine not elsewhere classified 50
060199 Biochemistry and Cell Biology not elsewhere classified 15
110399 Clinical Sciences not elsewhere classified 35

Professional Experience

UON Appointment

Title Organisation / Department
Professor University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia

Academic appointment

Dates Title Organisation / Department
Grant Review Panel 3B National Health & Medical Research Council of Australia (NH&MRC)
Australia
1/03/1994 - 1/06/2005 Senior Research Officer Monash University
Department of Physiology
Australia

Membership

Dates Title Organisation / Department
Member - Perinatal Society of Australian and NZ Perinatal Society of Australia and New Zealand
Australia

Invitations

Participant

Year Title / Rationale
2006 Protective role of neurosteroids in the perinatal brain
Organisation: Congress on Neuroendocrinology Description: Invited speaker at the 6th International Congress on Neuroendocrinology, Pittsburgh PA
1999 New approaches to the prevention of preterm labour
Organisation: Perinatal Society of Australia and New Zealand Description: Invited speaker at the 3rd annual meeting of the Perinatal Society of Australia and New Zealand, Melbourne
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Journal article (94 outputs)

Year Citation Altmetrics Link
2015 Bennett GA, Palliser HK, Shaw JC, Walker D, Hirst JJ, 'Prenatal Stress Alters Hippocampal Neuroglia and Increases Anxiety in Childhood.', Dev Neurosci, (2015)
DOI 10.1159/000437302
2015 Shaw JC, Palliser HK, Walker DW, Hirst JJ, 'Preterm birth affects GABAA receptor subunit mRNA levels during the foetal-to-neonatal transition in guinea pigs', Journal of Developmental Origins of Health and Disease, (2015)

Modulation of gamma-aminobutyric acid A (GABAA) receptor signalling by the neurosteroid allopregnanolone has a major role in late gestation neurodevelopment. The objective of this... [more]

Modulation of gamma-aminobutyric acid A (GABAA) receptor signalling by the neurosteroid allopregnanolone has a major role in late gestation neurodevelopment. The objective of this study was to characterize the mRNA levels of GABAA receptor subunits (a4, a5, a6 and d) that are key to neurosteroid binding in the brain, following preterm birth. Myelination, measured by the myelin basic protein immunostaining, was used to assess maturity of the preterm brains. Foetal guinea pig brains were obtained at 62 days¿ gestational age (GA, preterm) or at term (69 days). Neonates were delivered by caesarean section, at 62 days GA and term, and maintained until tissue collection at 24 h of age. Subunit mRNA levels were quantified by RT-PCR in the hippocampus and cerebellum of foetal and neonatal brains. Levels of the a6 and d subunits were markedly lower in the cerebellum of preterm guinea pigs compared with term animals. Importantly, there was an increase in mRNA levels of these subunits during the foetal-to-neonatal transition at term, which was not seen following preterm birth. Myelination was lower in preterm neonatal brains, consistent with marked immaturity. Salivary cortisol concentrations, measured by EIA, were also higher for the preterm neonates, suggesting greater stress. We conclude that there is an adaptive increase in the levels of mRNA of the key GABAA receptor subunits involved in neurosteroid action after term birth, which may compensate for declining allopregnanolone levels. The lower levels of these subunits in preterm neonates may heighten the adverse effect of the premature decline in neurosteroid exposure.

DOI 10.1017/S2040174415000069
Co-authors Hannah Palliser
2015 Palliser HK, Kelleher MA, Tolcos M, Walker DW, Hirst JJ, 'Effect of postnatal progesterone therapy following preterm birth on neurosteroid concentrations and cerebellar myelination in guinea pigs', Journal of Developmental Origins of Health and Disease, 6 350-361 (2015)

Allopregnanolone protects the fetal brain and promotes normal development including myelination. Preterm birth results in the early separation of the infant from the placenta and ... [more]

Allopregnanolone protects the fetal brain and promotes normal development including myelination. Preterm birth results in the early separation of the infant from the placenta and consequently a decline in blood and brain allopregnanolone concentrations. Progesterone therapy may increase allopregnanolone and lead to improved oligodendrocyte maturation. The objectives of this study were to examine the efficacy of progesterone replacement in augmenting allopregnanolone concentrations during the postnatal period and to assess the effect on cerebellar myelination - a region with significant postnatal development. Preterm guinea pig neonates delivered at 62 days of gestation by caesarean section received daily s.c. injections of vehicle (2-Hydroxypropyl-ß-cyclodextrin) or progesterone (16 mg/kg) for 8 days until term-equivalent age (TEA). Term delivered controls (PND1) received vehicle. Neonatal condition/wellbeing was scored, and salivary progesterone was sampled over the postnatal period. Brain and plasma allopregnanolone concentrations were measured by radioimmunoassay; cortisol and progesterone concentrations were determined by enzyme immunoassay; and myelin basic protein (MBP), proteolipid protein (PLP), oligodendroctye transcription factor 2 (OLIG2) and platelet-derived growth factor receptor-a (PDGFRa) were quantified by immunohistochemistry and western blot. Brain allopregnanolone concentrations were increased in progesterone-treated neonates. Plasma progesterone and cortisol concentrations were elevated in progesterone-treated male neonates. Progesterone treatment decreased MBP and PLP in lobule X of the cerebellum and total cerebellar OLIG2 and PDGFRa in males but not females at TEA compared with term animals. We conclude that progesterone treatment increases brain allopregnanolone concentrations, but also increases cortisol levels in males, which may disrupt developmental processes. Consideration should be given to the use of non-metabolizable neurosteroid agonists.

DOI 10.1017/S2040174415001075
Co-authors Hannah Palliser
2015 Palliser HK, Kelleher MA, Tolcos M, Walker DW, Hirst JJ, 'Effect of postnatal progesterone therapy following preterm birth on neurosteroid concentrations and cerebellar myelination in guinea pigs', Journal of Developmental Origins of Health and Disease, 6 350-361 (2015)

Allopregnanolone protects the fetal brain and promotes normal development including myelination. Preterm birth results in the early separation of the infant from the placenta and ... [more]

Allopregnanolone protects the fetal brain and promotes normal development including myelination. Preterm birth results in the early separation of the infant from the placenta and consequently a decline in blood and brain allopregnanolone concentrations. Progesterone therapy may increase allopregnanolone and lead to improved oligodendrocyte maturation. The objectives of this study were to examine the efficacy of progesterone replacement in augmenting allopregnanolone concentrations during the postnatal period and to assess the effect on cerebellar myelination - a region with significant postnatal development. Preterm guinea pig neonates delivered at 62 days of gestation by caesarean section received daily s.c. injections of vehicle (2-Hydroxypropyl-ß-cyclodextrin) or progesterone (16 mg/kg) for 8 days until term-equivalent age (TEA). Term delivered controls (PND1) received vehicle. Neonatal condition/wellbeing was scored, and salivary progesterone was sampled over the postnatal period. Brain and plasma allopregnanolone concentrations were measured by radioimmunoassay; cortisol and progesterone concentrations were determined by enzyme immunoassay; and myelin basic protein (MBP), proteolipid protein (PLP), oligodendroctye transcription factor 2 (OLIG2) and platelet-derived growth factor receptor-a (PDGFRa) were quantified by immunohistochemistry and western blot. Brain allopregnanolone concentrations were increased in progesterone-treated neonates. Plasma progesterone and cortisol concentrations were elevated in progesterone-treated male neonates. Progesterone treatment decreased MBP and PLP in lobule X of the cerebellum and total cerebellar OLIG2 and PDGFRa in males but not females at TEA compared with term animals. We conclude that progesterone treatment increases brain allopregnanolone concentrations, but also increases cortisol levels in males, which may disrupt developmental processes. Consideration should be given to the use of non-metabolizable neurosteroid agonists.

DOI 10.1017/S2040174415001075
Co-authors Hannah Palliser
2015 Palliser HK, Kelleher MA, Tolcos M, Walker DW, Hirst JJ, 'Effect of postnatal progesterone therapy following preterm birth on neurosteroid concentrations and cerebellar myelination in guinea pigs.', J Dev Orig Health Dis, 6 350-361 (2015)
DOI 10.1017/S2040174415001075
Co-authors Hannah Palliser
2014 Brunton PJ, Russell JA, Hirst JJ, 'Allopregnanolone in the brain: Protecting pregnancy and birth outcomes', PROGRESS IN NEUROBIOLOGY, 113 106-136 (2014) [C1]
DOI 10.1016/j.pneurobio.2013.08.005
Citations Scopus - 7Web of Science - 5
2014 Hirst JJ, Kelleher MA, Walker DW, Palliser HK, 'Neuroactive steroids in pregnancy: Key regulatory and protective roles in the foetal brain', Journal of Steroid Biochemistry and Molecular Biology, 139 144-153 (2014)
DOI 10.1016/j.jsbmb.2013.04.002
Citations Scopus - 2
Co-authors Hannah Palliser
2014 Hirst JJ, Kelleher MA, Walker DW, Palliser HK, 'Neuroactive steroids in pregnancy: Key regulatory and protective roles in the foetal brain', Journal of Steroid Biochemistry and Molecular Biology, 139 144-153 (2014) [C1]

Neuroactive steroid concentrations are remarkably high in the foetal brain during late gestation. These concentrations are maintained by placental progesterone synthesis and the i... [more]

Neuroactive steroid concentrations are remarkably high in the foetal brain during late gestation. These concentrations are maintained by placental progesterone synthesis and the interaction of enzymes in the placenta and foetal brain. 5a-Pregnane-3a-ol-20-one (allopregnanolone) is a key neuroactive steroid during foetal life, although other 3a-hydroxy- pregnanes may make an additional contribution to neuroactive steroid action. Allopregnanolone modulates GABAergic inhibition to maintain a suppressive action on the foetal brain during late gestation. This action suppresses foetal behaviour and maintains the appropriate balance of foetal sleep-like behaviours, which in turn are important to normal neurodevelopment. Neuroactive steroid-induced suppression of excitability has a key role in protecting the foetal brain from acute hypoxia/ischaemia insults. Hypoxia-induced brain injury is markedly increased if neuroactive steroid levels are suppressed and there is increased seizure activity. There is also a rapid increase in allopregnanolone synthesis and hence levels in response to acute stress that acts as an endogenous protective mechanism. Allopregnanolone has a trophic role in regulating development, maintaining normal levels of apoptosis and increasing myelination during late gestation in the brain. In contrast, chronic foetal stressors, including intrauterine growth restriction, do not increase neuroactive steroid levels in the brain and exposure to repeated synthetic corticosteroids reduce neuroactive steroid levels. The reduced availability of neuroactive steroids may contribute to the adverse effects of chronic stressors on the foetal and newborn brain. Preterm birth also deprives the foetus of neuroactive steroid mediated protection and may increase vulnerability to brain injury and suboptimal development. These finding suggest replacement therapies should be explored. This article is part of a Special Issue entitled 'Pregnancy and steroids © 2013 Elsevier Ltd. All rights reserved.

DOI 10.1016/j.jsbmb.2013.04.002
Citations Scopus - 5Web of Science - 3
Co-authors Hannah Palliser
2014 Hutton LC, Yan E, Yawno T, Castillo-Melendez M, Hirst JJ, Walker DW, 'Injury of the Developing Cerebellum: A Brief Review of the Effects of Endotoxin and Asphyxial Challenges in the Late Gestation Sheep Fetus', Cerebellum, 13 777-786 (2014)
DOI 10.1007/s12311-014-0602-3
2014 Hutton LC, Yan E, Yawno T, Castillo-Melendez M, Hirst JJ, Walker DW, 'Injury of the Developing Cerebellum: A Brief Review of the Effects of Endotoxin and Asphyxial Challenges in the Late Gestation Sheep Fetus', Cerebellum, 13 777-786 (2014) [C1]

The vulnerability of the fetal and newborn brain to events in utero or at birth that cause damage arising from perturbations of cerebral blood flow and metabolism, such as the acc... [more]

The vulnerability of the fetal and newborn brain to events in utero or at birth that cause damage arising from perturbations of cerebral blood flow and metabolism, such as the accumulation of free radicals and excitatory transmitters to neurotoxic levels, has received considerable attention over the last few decades. Attention has usually been on the damage to cerebral structures, particularly, periventricular white matter. The rapid growth of the cerebellum in the latter half of fetal life in species with long gestations, such as the human and sheep, suggests that this may be a particularly important time for the development of cerebellar structure and function. In this short review, we summarize data from recent studies with fetal sheep showing that the developing cerebellum is particularly sensitive to infectious processes, chronic hypoxia and asphyxia. The data demonstrates that the cerebellum should be further studied in insults of this nature as it responds differently to the remainder of the brain. Damage to this region of the brain has implications not only for the development of motor control and posture, but also for higher cognitive processes and the subsequent development of complex behaviours, such as learning, memory and attention.

DOI 10.1007/s12311-014-0602-3
2014 Welsh TN, Hirst JJ, Palliser H, Zakar T, 'Progesterone Receptor Expression Declines in the Guinea Pig Uterus during Functional Progesterone Withdrawal and in Response to Prostaglandins', PLOS ONE, 9 (2014) [C1]
DOI 10.1371/journal.pone.0105253
Co-authors Hannah Palliser
2014 Palliser HK, Kelleher MA, Welsh TN, Zakar T, Hirst JJ, 'Mechanisms Leading to Increased Risk of Preterm Birth in Growth-Restricted Guinea Pig Pregnancies', REPRODUCTIVE SCIENCES, 21 269-276 (2014) [C1]
DOI 10.1177/1933719113497268
Co-authors Hannah Palliser
2014 Cumberland AL, Palliser HK, Hirst JJ, 'Increased placental neurosteroidogenic gene expression precedes poor outcome in the preterm guinea pig', Journal of Developmental Origins of Health and Disease, 5 74-78 (2014) [C1]

Placental 5a-reductase (5aR) is influenced by in utero compromises and has a role in regulating neuroactive steroid concentrations in the fetus. The objective of this study was to... [more]

Placental 5a-reductase (5aR) is influenced by in utero compromises and has a role in regulating neuroactive steroid concentrations in the fetus. The objective of this study was to determine if changes in placental 5aR were associated with neonatal outcome after birth. Guinea pigs were delivered by cesarean section at term (GA69, n=22) or preterm (GA62, n=36) and the placenta collected. Preterm neonates were maintained for 24 h unless their condition deteriorated before this time. Enzyme mRNA expression of 5aR type-1 and 5aR type-2 were determined using real-time PCR. All preterm neonates had significantly higher 5aR2 expression in their placenta compared with placentae from term neonates (P<0.0001). Expression was also markedly higher in the placentae from neonates that did not survive until 24 h, compared with surviving preterm neonates (P=0.04). These findings suggest differences of in utero neurosteroidogenic capacity between surviving and non-surviving preterm guinea pig neonates. The increased 5aR2 mRNA expression in the placenta of non-survivors suggests an induction of the neurosteroid pathway due to prior exposure to an in utero compromise, with such exposure possibly a predisposing factor that contributed to their poor ex utero outcome. © 2014 Cambridge University Press.

DOI 10.1017/S2040174413000573
Co-authors Hannah Palliser
2014 Shaw JC, Palliser HK, Walker DW, Hirst JJ, 'Preterm birth affects GABAA receptor subunit mRNA levels during the foetal-to-neonatal transition in guinea pigs', Journal of Developmental Origins of Health and Disease, 6 250-260 (2014)

Modulation of gamma-aminobutyric acid A (GABA<inf>A</inf>) receptor signalling by the neurosteroid allopregnanolone has a major role in late gestation neurodevelopment. The object... [more]

Modulation of gamma-aminobutyric acid A (GABAA) receptor signalling by the neurosteroid allopregnanolone has a major role in late gestation neurodevelopment. The objective of this study was to characterize the mRNA levels of GABAA receptor subunits (a4, a5, a6 and d) that are key to neurosteroid binding in the brain, following preterm birth. Myelination, measured by the myelin basic protein immunostaining, was used to assess maturity of the preterm brains. Foetal guinea pig brains were obtained at 62 days' gestational age (GA, preterm) or at term (69 days). Neonates were delivered by caesarean section, at 62 days GA and term, and maintained until tissue collection at 24 h of age. Subunit mRNA levels were quantified by RT-PCR in the hippocampus and cerebellum of foetal and neonatal brains. Levels of the a6 and d subunits were markedly lower in the cerebellum of preterm guinea pigs compared with term animals. Importantly, there was an increase in mRNA levels of these subunits during the foetal-to-neonatal transition at term, which was not seen following preterm birth. Myelination was lower in preterm neonatal brains, consistent with marked immaturity. Salivary cortisol concentrations, measured by EIA, were also higher for the preterm neonates, suggesting greater stress. We conclude that there is an adaptive increase in the levels of mRNA of the key GABAA receptor subunits involved in neurosteroid action after term birth, which may compensate for declining allopregnanolone levels. The lower levels of these subunits in preterm neonates may heighten the adverse effect of the premature decline in neurosteroid exposure.

DOI 10.1017/S2040174415000069
Co-authors Hannah Palliser
2013 Bennett GA, Palliser HK, Saxby B, Walker DW, Hirst JJ, 'Effects of Prenatal Stress on Fetal Neurodevelopment and Responses to Maternal Neurosteroid Treatment in Guinea Pigs', DEVELOPMENTAL NEUROSCIENCE, 35 416-426 (2013) [C1]
DOI 10.1159/000354176
Citations Scopus - 4Web of Science - 4
Co-authors Hannah Palliser
2013 Mitchell CM, Sykes SD, Pan X, Pringle KG, Lumbers ER, Hirst JJ, Zakar T, 'Inflammatory and steroid receptor gene methylation in the human amnion and decidua', JOURNAL OF MOLECULAR ENDOCRINOLOGY, 50 267-277 (2013) [C1]
DOI 10.1530/JME-12-0211
Citations Scopus - 3Web of Science - 3
Co-authors Kirsty Pringle
2013 Kelleher MA, Hirst JJ, Palliser HK, 'Changes in neuroactive steroid concentrations after preterm delivery in the guinea pig', Reproductive Sciences, 20 1365-1375 (2013) [C1]

Background: Preterm birth is a major cause of neurodevelopmental disorders. Allopregnanolone, a key metabolite of progesterone, has neuroprotective and developmental effects in th... [more]

Background: Preterm birth is a major cause of neurodevelopmental disorders. Allopregnanolone, a key metabolite of progesterone, has neuroprotective and developmental effects in the brain. The objectives of this study were to measure the neuroactive steroid concentrations following preterm delivery in a neonatal guinea pig model and assess the potential for postnatal progesterone replacement therapy to affect neuroactive steroid brain and plasma concentrations in preterm neonates. Methods: Preterm (62-63 days) and term (69 days) guinea pig pups were delivered by cesarean section and tissue was collected at 24 hours. Plasma progesterone, cortisol, allopregnanolone, and brain allopregnanolone concentrations were measured by immunoassay. Brain 5a-reductase (5aR) expression was determined by Western blot. Neurodevelopmental maturity of preterm neonates was assessed by immunohistochemistry staining for myelination, glial cells, and neurons. Results: Brain allopregnanolone concentrations were significantly reduced after birth in both preterm and term neonates. Postnatal progesterone treatment in preterm neonates increased brain and plasma allopregnanolone concentrations. Preterm neonates had reduced myelination, low birth weight, and high mortality compared to term neonates. Brain 5aR expression was also significantly reduced in neonates compared to fetal expression. Conclusions: Delivery results in a loss of neuroactive steroid concentrations resulting in a premature reduction in brain allopregnanolone in preterm neonates. Postnatal progesterone therapy reestablished neuroactive steroid levels in preterm brains, a finding that has implications for postnatal growth following preterm birth that occurs at a time of neurodevelopmental immaturity. © 2013 The Author(s).

DOI 10.1177/1933719113485295
Citations Scopus - 4Web of Science - 3
Co-authors Hannah Palliser
2012 Fleiss B, Parkington HC, Coleman HA, Dickinson H, Yawno T, Castillo-Melendez M, et al., 'Effect of maternal administration of allopregnanolone before birth asphyxia on neonatal hippocampal function in the spiny mouse', Brain Research, 1433 9-19 (2012) [C1]
Citations Scopus - 2Web of Science - 2
2012 Palliser HK, Yates DM, Hirst JJ, 'Progesterone receptor isoform expression in response to in utero growth restriction in the fetal guinea pig brain', Neuroendocrinology, 96 60-67 (2012) [C1]
Citations Scopus - 4Web of Science - 4
Co-authors Hannah Palliser
2012 Dyson RM, Palliser HK, Kelleher MA, Hirst JJ, Wright IM, 'The guinea pig as an animal model for studying perinatal changes in microvascular function', Pediatric Research, 71 20-24 (2012) [C1]
DOI 10.1038/pr.2011.9
Citations Scopus - 6Web of Science - 5
Co-authors Ian Wright, Hannah Palliser
2012 Welsh T, Caritis S, Hirst J, Mesiano S, Zakar T, 'Progesterone Withdrawal in the Pregnant Guinea Pig Is Mediated by Decreased Uterine PR Expression and Stimulated by Prostaglandins In Vivo', REPRODUCTIVE SCIENCES, 19 192A-192A (2012) [E3]
Citations Web of Science - 1
2012 Welsh T, Paul J, Palliser H, Hirst J, Mesiano S, Zakar T, 'PGDH Expression Decreases at Term before Labor Onset in Guinea Pig Fetal Membranes', REPRODUCTIVE SCIENCES, 19 192A-192A (2012) [C3]
Citations Web of Science - 1
Co-authors Hannah Palliser
2012 Mitchell CM, Chai S, Madsen G, Hirst JJ, Zakar T, 'Bivalent Epigenetic Modifications Regulate PTGS2 Expression during Gestation in the Amnion', REPRODUCTIVE SCIENCES, 19 299A-299A (2012) [E3]
2012 Welsh TN, Paul JW, Palliser HK, Tabatabaeehatambakhsh SH, Hirst JJ, Mesiano S, Zakar T, '15-hydroxyprostaglandin dehydrogenase expression and localization in guinea pig gestational tissues during late pregnancy and parturition', Reproductive Sciences, 19 1099-1109 (2012) [C1]
DOI 10.1177/1933719112442247
Citations Scopus - 2Web of Science - 2
Co-authors Jonathan Paul, Hannah Palliser
2011 Pringle KG, Zakar T, Roach DM, Mitchell CM, Hirst JJ, Lumbers ER, 'Molecular evidence of a (pro)renin/(pro)renin receptor system in human intrauterine tissues in pregnancy and its association with PGHS-2', Journal of the Renin-Angiotensin-Aldosterone System, 12 304-310 (2011) [C1]
DOI 10.1177/1470320310376554
Citations Scopus - 9Web of Science - 7
Co-authors Kirsty Pringle
2011 Marques FZ, Pringle KG, Conquest AL, Hirst JJ, Markus MA, Sarris M, et al., 'Molecular characterization of renin-angiotensin system components in human intrauterine tissues and fetal membranes from vaginal delivery and cesarean section', Placenta, 32 214-221 (2011) [C1]
DOI 10.1016/j.placenta.2010.12.006
Citations Scopus - 16Web of Science - 15
Co-authors Kirsty Pringle
2011 Mitchell CM, Johnson R, Bisits AM, Hirst JJ, Zakar T, 'PTGS2 (Prostaglandin Endoperoxide Synthase-2) expression in term human amnion in vivo involves rapid mRNA turnover, polymerase-II 5 '-pausing, and glucocorticoid transrepression', Endocrinology, 152 2113-2122 (2011) [C1]
Citations Scopus - 5Web of Science - 4
2011 Kelleher MA, Palliser HK, Walker DW, Hirst JJ, 'Sex-dependent effect of a low neurosteroid environment and intrauterine growth restriction on foetal guinea pig brain development', Journal of Endocrinology, 208 301-309 (2011) [C1]
DOI 10.1677/joe-10-0248
Citations Scopus - 10Web of Science - 10
Co-authors Hannah Palliser
2011 Yawno T, Yan EB, Hirst JJ, Walker DW, 'Neuroactive steroids induce changes in fetal sheep behavior during normoxic and asphyxic states', Stress, 14 13-22 (2011) [C1]
DOI 10.3109/10253890.2010.504789
Citations Scopus - 3Web of Science - 3
2011 Frye CA, Hirst JJ, Brunton PJ, Russell JA, 'Neurosteroids for a successful pregnancy', Stress, 14 1-5 (2011) [C3]
DOI 10.3109/10253890.2010.540050
Citations Scopus - 4Web of Science - 4
2010 Palliser HK, Zakar T, Symonds IM, Hirst JJ, 'Progesterone receptor isoform expression in the guinea pig myometrium from normal and growth restricted pregnancies', Reproductive Sciences, 17 776-782 (2010) [C1]
DOI 10.1177/1933719110371517
Citations Scopus - 8Web of Science - 7
Co-authors Hannah Palliser, Ian Symonds
2010 Dellios NL, Lappas M, Young IR, Palliser HK, Hirst JJ, Oliva K, et al., 'Increased expression of alpha-enolase in cervico-vaginal fluid during labour', European Journal of Obstetrics Gynecology and Reproductive Biology, 153 16-22 (2010) [C1]
DOI 10.1016/j.ejogrb.2010.06.014
Citations Scopus - 2Web of Science - 2
Co-authors Hannah Palliser
2010 McKendry AA, Palliser HK, Yates DM, Walker DW, Hirst JJ, 'The effect of betamethasone treatment on neuroactive steroid synthesis in a foetal guinea pig model of growth restriction', Journal of Neuroendocrinology, 22 166-174 (2010) [C1]
DOI 10.1111/j.1365-2826.2009.01949.x
Citations Scopus - 16Web of Science - 15
Co-authors Hannah Palliser
2009 Yawno T, Hirst JJ, Castillo-Melendez M, Walker DW, 'Role of neurosteroids in regulating cell death and proliferation in the late gestation fetal brain', Neuroscience, 163 838-847 (2009) [C1]
DOI 10.1016/j.neuroscience.2009.07.009
Citations Scopus - 25Web of Science - 24
2009 Hirst JJ, Walker DW, Yawno T, Palliser HK, 'Stress in pregnancy: A role for neuroactive steroids in protecting the fetal and neonatal brain', Developmental Neuroscience, 31 363-377 (2009) [C1]
DOI 10.1159/000232555
Citations Scopus - 18Web of Science - 15
Co-authors Hannah Palliser
2009 Vu TT, Hirst JJ, Stark MJ, Wright IM, Palliser HK, Hodyl NA, Clifton VL, 'Changes in human placental 5 alpha-reductase isoenzyme expression with advancing gestation: Effects of fetal sex and glucocorticoid exposure', Reproduction Fertility and Development, 21 599-607 (2009) [C1]
DOI 10.1071/rd08224
Citations Scopus - 14Web of Science - 13
Co-authors Hannah Palliser, Ian Wright, Vicki Clifton
2009 Winnall WR, Muir JA, Liew S, Hirst JJ, Meachem SJ, Hedger MP, 'Effects of chronic celecoxib on testicular function in normal and lipopolysaccharide-treated rats', International Journal of Andrology, 32 542-555 (2009) [C1]
DOI 10.1111/j.1365-2605.2008.00895.x
Citations Scopus - 14Web of Science - 12
2008 Westcott KT, Hirst JJ, Ciurej I, Walker DW, Wlodek ME, 'Brain allopregnanolone in the fetal and postnatal rat in response to uteroplacental insufficiency', Neuroendocrinology, 88 287-292 (2008) [C1]
DOI 10.1159/000139771
Citations Scopus - 7Web of Science - 7
2008 Hirst JJ, Palliser HK, Roach DM, Yawno T, Walker DW, 'Neurosteroids in the fetus and neonate: Potential protective role in compromised pregnancies', Neurochemistry International, 52 602-610 (2008) [C1]
DOI 10.1016/j.neuint.2007.07.018
Citations Scopus - 20Web of Science - 17
Co-authors Hannah Palliser
2007 Yawno T, Yan EB, Walker DW, Hirst JJ, 'Inhibition of neurosteroid synthesis increases asphyxia-induced brain injury in the late gestation fetal sheep', Neuroscience, 146 1726-1733 (2007) [C1]
DOI 10.1016/j.neuroscience.2007.03.023
Citations Scopus - 40Web of Science - 37
2007 Hutton LC, Yan E, Yawno T, Castillo-Melendez M, Hirst JJ, Walker DW, 'Injury of the developing cerebellum: A brief review of the effects of endotoxin and asphyxial challenges in the late gestation sheep fetus.', Cerebellum (London, England), 1-10 (2007)
DOI 10.1080/14734220701358556
2007 Young R, Rice GE, Palliser HK, Ayhan M, Dellios NL, Hirst JJ, 'Identification of bactenecin-1 in cervicovaginal fluid by two-dimensional electrophoresis in an ovine model of preterm labour', Proteomics, 7 281-288 (2007) [C1]
DOI 10.1002/pmic.200500705
Citations Scopus - 4Web of Science - 5
Co-authors Hannah Palliser
2007 Smith R, Van Helden DF, Hirst JJ, Zakar T, Read MA, Chan EC, et al., 'Pathological interactions with the timing of birth and uterine activation', Australian & New Zealand Journal of Obstetrics & Gynaecology, 47 430-437 (2007) [C1]
DOI 10.1111/j.1479-828x.2007.00775.x
Citations Scopus - 8Web of Science - 8
Co-authors Roger Smith, Dirk Vanhelden, Hannah Palliser
2007 Winnall WR, Ali U, O'Bryan MK, Hirst JJ, Whiley PAF, Muir JA, Hedger MP, 'Constitutive expression of prostaglandin-endoperoxide synthase 2 by somatic and spermatogenic cells is responsible for prostaglandin E2 production in the adult rat testis', Biology of Reproduction, 76 759-768 (2007) [C1]
DOI 10.1095/biolreprod.106.053124
Citations Scopus - 21Web of Science - 22
2006 Hirst JJ, Yawno T, Nguyen P, Walker DW, 'Stress in Pregnancy Activates Neurosteroid Production in the Fetal Brain', Neuroendocrinology, 84 264-274 (2006) [C1]
DOI 10.1159/000097990
Citations Scopus - 24Web of Science - 22
2006 Ochsenkuhn R, O'Connor AE, Hirst JJ, Baker HWG, De Kretser DM, Hedger MP, 'The relationship between immunosuppressive activity and immunoregulatory cytokines in seminal plasma: Influence of sperm autoimmunity and seminal leukocytes', Journal of reproductive immunology, 71 57-74 (2006) [C1]
DOI 10.1016/j.jri.2006.01.002
Citations Scopus - 14Web of Science - 14
2006 Palliser HK, Dellios N, Escalona R, Ooi G, Rice GE, Hirst J, Young IR, 'Labor-Associated Regulation of Prostaglandin E and F Synthesis and Action in the Ovine Amnion and Cervix', Reproductive Sciences, 13 19-24 (2006) [C1]
DOI 10.1016/j.jsgi.2005.09.009
Citations Scopus - 5Web of Science - 5
Co-authors Hannah Palliser
2006 Billiards SS, Guyen PN, Scheerlinck J-P, Phillips DJ, Canny BJ, Walker DW, Hirst JJ, 'Hypoxia potentiates endotoxin-induced allopregnanolone concentrations in the newborn brain', Biology of the Neonate, 90 258-267 (2006) [C1]
DOI 10.1159/000094146
Citations Scopus - 12Web of Science - 11
2005 Manuepillai U, Ligam P, Smythe GA, Wallace EM, Phillips D, Guilemin GJ, et al., 'Identification of kynurenine pathway enzyme mRNAs and metabolites in human placenta: Up-regulation by inflammatory stimuli and with clinical infection', American Journal of Obstetrics and Gynecology, 192 280-288 (2005) [C1]
DOI 10.1016/j.ajog.2004.06.090
Citations Scopus - 18Web of Science - 15
2005 Hirst JJ, Parkington HC, Young IR, Palliser HK, Peri KG, Olsen DM, 'Delay of preterm birth in sheep by THG113.31, a prostaglandin F2[a] receptor antagonist', American Journal of Obstetrics and Gynecology, 193 256-266 (2005) [C1]
DOI 10.1016/j.ajog.2004.11.009
Citations Scopus - 23Web of Science - 22
Co-authors Hannah Palliser
2005 Palliser HK, Hirst J, Ooi GT, Rice GE, Escalona RM, Dellios NL, et al., 'Prostaglandin E and F receptor expression and myometrial sensitivity at labour onset in sheep', Biology of Reproduction, 72 937-943 (2005) [C1]
DOI 10.1095/biolreprod.104.035311
Citations Scopus - 15Web of Science - 15
Co-authors Hannah Palliser
2005 Azari MF, Profyris C, Le Grande MR, Lopes ES, Hirst J, Petratos S, Cheema S, 'Effects of intraperitoneal injection of Rofecoxib in a mouse model of ALS', European Journal of Neurology, 12 357-364 (2005) [C1]
DOI 10.1111/j.1468-1331.2004.00987.x
Citations Scopus - 22Web of Science - 18
2004 Nguyen PN, Young IR, Walker DW, Hirst J, 'Allopregnanolone in the brain and blood after disruption of the hypothalamic-pituitary-adrenal axis in fetal sheep', Journal of Endocrinology, 182 81-88 (2004) [C1]
DOI 10.1677/joe.0.1820081
Citations Scopus - 16Web of Science - 16
2004 Palliser HK, Dellios N, Escalona R, Ooi G, Rice GE, Hirst J, Young IR, 'Changes in the Expression of prostaglandin E and F synthases at induced and spontaneous labour onset in the sheep', Journal of Endocrinology, 180 469-477 (2004) [C1]
DOI 10.1677/joe.0.1800469
Citations Scopus - 19Web of Science - 17
Co-authors Hannah Palliser
2004 Nguyen PN, Yan EB, Castillo-Melendez M, Walker DW, Hirst J, 'Increased allopregnanolone levels in the fetal sheep brain following umbilical cord occlusion', The Journal of Physiology, 560 593-602 (2004) [C1]
DOI 10.1113/jphysiol.2004.069336
Citations Scopus - 33Web of Science - 35
2004 Yan EB, Nichols T, Hirst J, Walker DW, 'Cerebrovascular Responses in the Fetal Sheep Brain to Low-Dose Endotoxin', Pediatric Research, 55 855-863 (2004) [C1]
DOI 10.1203/01.PDR.0000115681.95957.D4
Citations Scopus - 46Web of Science - 44
2003 Hirst J, Scheerlinbeck JP, Phillips DJ, Jenkin G, Grigsby PL, 'Fetal responses to maternal and intra-amniotic administration of lipopolysaccharide administration in sheep', Biology of Reproduction, 68 1695-1702 (2003) [C1]
DOI 10.1095/biolreprod.102.009688
Citations Scopus - 32Web of Science - 30
2003 Crossley KJ, Nitsos I, Walker DW, Lawrence AJ, Beart PM, Hirst J, 'Steroid-sensitive GABAA receptors in the fetal sheep brain', Neuropharmacology, 45 461-472 (2003) [C1]
DOI 10.1016/S0028-3908(03)00196-5
Citations Scopus - 4Web of Science - 4
2003 Nguyen PN, Billiards SS, Walker DW, Hirst J, 'Changes in 5[alpha]-pregnane steroids and neurosteroidogenic enzyme expression in the perinatal sheep', Pediatric Research, 53 956-964 (2003) [C1]
DOI 10.1203/01.PDR.0000064905.64688.10
Citations Scopus - 38Web of Science - 38
2003 Nguyen PN, Billiards SS, Walker DW, Hirst J, 'Changes in 5[alpha]-pregnane steroids and neurosteroidogenic enzyme expression in fetal sheep with umbilicoplacental embolisation', Pediatric Research, 54 840-847 (2003) [C1]
DOI 10.1203/01.PDR.0000088066.47755.36
Citations Scopus - 21Web of Science - 22
2003 Olson DM, Zaragoza DB, Shallow MC, Cook JL, Mitchell BF, Grigsby PL, Hirst J, 'Myometrial activation and preterm labour: evidence supporting a role for the prostaglandin F receptor--a review', Placenta, 24 47-54 (2003) [C1]
DOI 10.1053/plac.2002.0938
Citations Scopus - 34Web of Science - 28
2002 Billiards SS, Walker DW, Canny BJ, Hirst J, 'Endotoxin Increases Sleep and Brain Allopregnanolone Concentrations in Newborn Lambs', Paediatric Research, 52 892-899 (2002) [C1]
Citations Scopus - 25Web of Science - 25
2002 Lee B, Hirst JJ, Walker DW, 'Prostaglandin D synthase in the prenatal ovine brain and effects of its inhibition with selenium chloride on fetal sleep/wake activity in utero', JOURNAL OF NEUROSCIENCE, 22 5679-5686 (2002)
Citations Scopus - 13Web of Science - 12
2002 Lee B, Hirst J, Walker DW, 'Inhibition of prostaglandin D synthase by intraventriculalar administration of selenium chloride induces behavioural arousal in the ovine fetus. 5679-5686 (2002) [C1]
2002 Haluska GJ, Wells T, Hirst J, Brenner R, Sadowsky M, Novy DW, 'Progesterone receptor localization and isoforms in myometrium, decidua and fetal membranes from rhesus monkeys: evidence for functional progesterone withdrawal at parturition.', Journal of Society for Gynaecological Investigation, 9 125-136 (2002) [C1]
Citations Web of Science - 64
2001 Nicol MB, Hirst JJ, Walker DW, 'Effect of finasteride on behavioural arousal and somatosensory evoked potentials in fetal sheep', NEUROSCIENCE LETTERS, 306 13-16 (2001)
DOI 10.1016/S0304-3940(01)01861-4
Citations Scopus - 22Web of Science - 22
2001 Scott JE, Grigsby PL, Hirst JJ, Jenkin G, 'Inhibition of prostaglandin synthesis and its effect on uterine activity during established premature labor in sheep', JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION, 8 266-276 (2001)
DOI 10.1016/S1071-5576(01)00124-1
Citations Scopus - 10Web of Science - 9
2001 Scott J, Grigsby P, Hirst J, Jenkin G, 'Inhibition of prostaglandin release and its effect on uterine activity during induced premature labour in late pregnant sheep. 266-276 (2001) [C1]
2001 Nicol MB, Walker DW, Hirst J, 'Effect of the 5a-reductase, finasteride, on fetal behavioural state.', Neuroscience Letters, 306 13-16 (2001) [C1]
2000 Crossley KJ, Walker DW, Beart PM, Hirst JJ, 'Characterisation of GABA(A) receptors in fetal, neonatal and adult ovine brain: region and age related changes and the effects of allopregnanolone', NEUROPHARMACOLOGY, 39 1514-1522 (2000)
DOI 10.1016/S0028-3908(99)00222-1
Citations Web of Science - 25
2000 Hirst JJ, Egodagamage KC, Walker DW, 'Effect of a neuroactive steroid infused into the cerebral ventricles of fetal sheep in utero using small infusion volumes', JOURNAL OF NEUROSCIENCE METHODS, 97 37-44 (2000)
DOI 10.1016/S0165-0270(00)00162-X
Citations Web of Science - 7
2000 Petratos S, Hirst JJ, Mendis S, Anikijenko P, Walker DW, 'Localization of P450scc and 5 alpha-reductase type-2 in the cerebellum of fetal and newborn sheep', DEVELOPMENTAL BRAIN RESEARCH, 123 81-86 (2000)
DOI 10.1016/S0165-3806(00)00076-6
Citations Web of Science - 19
2000 Walker DW, Lee B, Hirst J, 'Inhibition of prostaglandin D synthase in fetal sheep brain with selenium chloride induces arousal.', FASEB JOURNAL, 14 A388-A388 (2000)
2000 Hirst JJ, Petratos S, Mendis S, Walker DW, 'Neuroactive steroid synthesis in the ovine fetal and newborn brain', FASEB JOURNAL, 14 A654-A654 (2000)
2000 Grigsby PL, Poore KR, Hirst JJ, Jenkin G, 'Inhibition of premature labor in sheep by a combined treatment of nimesulide, a prostaglandin synthase type 2 inhibitor, and atosiban, an oxytocin receptor antagonist', AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 183 649-657 (2000)
DOI 10.1067/mob.2000.106584
Citations Web of Science - 20
1999 Poore KR, Young IR, Hirst JJ, 'Efficacy of the selective prostaglandin synthase type 2 inhibitor nimesulide in blocking basal prostaglandin production and delaying glucocorticoid-induced premature labor in sheep', AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 180 1244-1253 (1999)
DOI 10.1016/S0002-9378(99)70624-1
Citations Web of Science - 31
1999 Nicol MB, Hirst JJ, Walker D, 'Effects of pregnanolone on behavioural parameters and the responses to GABA(A) receptor antagonists in the late gestation fetal sheep', NEUROPHARMACOLOGY, 38 49-63 (1999)
DOI 10.1016/S0028-3908(98)00166-X
Citations Web of Science - 26
1998 Nicol MB, Hirst JJ, Walker DW, 'Effect of pregnane steroids on electrocortical activity and somatosensory evoked potentials in fetal sheep', NEUROSCIENCE LETTERS, 253 111-114 (1998)
DOI 10.1016/S0304-3940(98)00627-2
Citations Web of Science - 18
1998 Hirst JJ, Mijovic JE, Zakar T, Olson DM, 'Prostaglandin endoperoxide H synthase-1 and -2 mRNA levels and enzyme activity in human decidua at term labor', JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION, 5 13-20 (1998)
DOI 10.1016/S1071-5576(97)00101-9
Citations Web of Science - 25
1997 Nicol MB, Hirst JJ, Walker D, Thorburn GD, 'Effect of alteration of maternal plasma progesterone concentrations on fetal behavioural state during late gestation', JOURNAL OF ENDOCRINOLOGY, 152 379-386 (1997)
DOI 10.1677/joe.0.1520379
Citations Web of Science - 29
1997 Crossley KJ, Nicol MB, Hirst JJ, Walker DW, Thorburn GD, 'Suppression of arousal by progesterone in fetal sheep', REPRODUCTION FERTILITY AND DEVELOPMENT, 9 767-773 (1997)
DOI 10.1071/R97074
Citations Web of Science - 33
1996 Zakar T, Olson DM, Teixeira FJ, Hirst JJ, 'Regulation of prostaglandin endoperoxide H2 synthase in term human gestational tissues.', Acta physiologica Hungarica, 84 109-118 (1996)
1995 ZAKAR T, HIRST JJ, MIJOVIC JE, OLSON DM, 'GLUCOCORTICOIDS STIMULATE THE EXPRESSION OF PROSTAGLANDIN ENDOPEROXIDE-H SYNTHASE-2 IN AMNION CELLS', ENDOCRINOLOGY, 136 1610-1619 (1995)
DOI 10.1210/en.136.4.1610
Citations Web of Science - 82
1995 HIRST JJ, TEIXEIRA FJ, ZAKAR T, OLSON DM, 'PROSTAGLANDIN ENDOPEROXIDE-H SYNTHASE-1 AND SYNTHASE-2 MESSENGER-RIBONUCLEIC-ACID LEVELS IN HUMAN AMNION WITH SPONTANEOUS LABOR ONSET', JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 80 517-523 (1995)
DOI 10.1210/jc.80.2.517
Citations Web of Science - 114
1994 TEIXEIRA FJ, ZAKAR T, HIRST JJ, GUO F, SADOWSKY DW, MACHIN G, et al., 'PROSTAGLANDIN ENDOPEROXIDE-H SYNTHASE (PGHS) ACTIVITY AND IMMUNOREACTIVE PGHS-1 AND PGHS-2 LEVELS IN HUMAN AMNION THROUGHOUT GESTATION, AT TERM, AND DURING LABOR', JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 78 1396-1402 (1994)
DOI 10.1210/jc.78.6.1396
Citations Web of Science - 101
1994 ZAKAR T, TEIXEIRA FJ, HIRST JJ, GUO F, MACLEOD EA, OLSON DM, 'REGULATION OF PROSTAGLANDIN ENDOPEROXIDE-H SYNTHASE BY GLUCOCORTICOIDS AND ACTIVATORS OF PROTEIN-KINASE-C IN THE HUMAN AMNION', JOURNAL OF REPRODUCTION AND FERTILITY, 100 43-50 (1994)
Citations Web of Science - 23
1993 HIRST JJ, HALUSKA GJ, COOK MJ, NOVY MJ, 'PLASMA OXYTOCIN AND NOCTURNAL UTERINE ACTIVITY - MATERNAL BUT NOT FETAL CONCENTRATIONS INCREASE PROGRESSIVELY DURING LATE PREGNANCY AND DELIVERY IN RHESUS-MONKEYS', AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 169 415-422 (1993)
Citations Scopus - 28Web of Science - 28
1993 SLAYDEN OD, HIRST JJ, BRENNER RM, 'ESTROGEN ACTION IN THE REPRODUCTIVE-TRACT OF RHESUS-MONKEYS DURING ANTIPROGESTIN TREATMENT', ENDOCRINOLOGY, 132 1845-1856 (1993)
DOI 10.1210/en.132.4.1845
Citations Web of Science - 91
1993 HIRST JJ, CHIBBAR R, MITCHELL BF, 'ROLE OF OXYTOCIN IN THE REGULATION OF UTERINE ACTIVITY DURING PREGNANCY AND IN THE INITIATION OF LABOR', SEMINARS IN REPRODUCTIVE ENDOCRINOLOGY, 11 219-233 (1993)
DOI 10.1055/s-2007-1018836
Citations Web of Science - 12
1992 HIRST JJ, WEST NB, BRENNER RM, NOVY MJ, 'STEROID-HORMONE RECEPTORS IN THE ADRENAL-GLANDS OF FETAL AND ADULT RHESUS-MONKEYS', JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 75 308-314 (1992)
DOI 10.1210/jc.75.1.308
Citations Web of Science - 53
1991 HIRST JJ, HALUSKA GJ, COOK MJ, HESS DL, NOVY MJ, 'COMPARISON OF PLASMA OXYTOCIN AND CATECHOLAMINE CONCENTRATIONS WITH UTERINE ACTIVITY IN PREGNANT RHESUS-MONKEYS', JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 73 804-810 (1991)
Citations Web of Science - 42
1990 HIRST JJ, RICE GE, JENKIN G, THORBURN GD, 'REGULATION OF OXYTOCIN SECRETION BY THE OVINE CORPUS-LUTEUM - EFFECT OF ACTIVATORS OF PROTEIN KINASE-C', JOURNAL OF ENDOCRINOLOGY, 124 225-232 (1990)
DOI 10.1677/joe.0.1240225
Citations Scopus - 1Web of Science - 5
1988 HIRST JJ, RICE GE, JENKIN G, THORBURN GD, 'CONTROL OF OXYTOCIN SECRETION BY OVINE CORPORA-LUTEA - EFFECTS OF ARACHIDONIC-ACID, PHOSPHOLIPASES, AND PROSTAGLANDINS', ENDOCRINOLOGY, 122 774-781 (1988)
Citations Scopus - 13Web of Science - 37
1986 HIRST JJ, RICE GE, JENKIN G, THORBURN GD, 'SECRETION OF OXYTOCIN AND PROGESTERONE BY OVINE CORPORA-LUTEA INVITRO', BIOLOGY OF REPRODUCTION, 35 1106-1114 (1986)
DOI 10.1095/biolreprod35.5.1106
Citations Scopus - 15Web of Science - 40
Show 91 more journal articles

Conference (75 outputs)

Year Citation Altmetrics Link
2012 Zakar T, Hirst JJ, Welsh TN, 'The guinea pig model of human parturition', Proceedings of the 39th Annual Meeting of the Fetal and Neonatal Physiological Society, Zeist, The Netherlands (2012) [E3]
2012 Bennett GA, Palliser HK, Kelleher MA, Saxby BM, Walker DW, Hirst JJ, 'Prenatal maternal psychosomatic stress: Effects on fetal brain development following maternal neurosteroid treatment in guinea pigs', Proceedings of the 39th Annual Meeting of the Fetal and Neonatal Physiological Society, Zeist, The Netherlands (2012) [E3]
Co-authors Hannah Palliser
2012 Palliser HK, Kelleher MA, Saxby B, Walker DW, Hirst JJ, Bennett GA, 'Prenatal stress and effect of maternal neurosteroid treatment on fetal brain development in guinea pigs', Journal of Paediatrics and Child Health, Sydney, Australia (2012) [E3]
Co-authors Hannah Palliser
2012 Palliser HK, Hirst JJ, 'Vulnerability of compromised pregnancies to preterm labour', Journal of Paediatrics and Child Health, Sydney, Australia (2012) [E3]
Co-authors Hannah Palliser
2012 Welsh TN, Caritis S, Hirst JJ, Mesiano S, Zakar T, 'Progesterone withdrawal in the pregnant guinea pig is mediated by decreased uterine PR expression and stimulated by prostaglandins in vivo', Reproductive Sciences, San Diego, CA (2012) [E3]
2012 Mitchell CM, Chai S, Madsen GM, Hirst JJ, Zakar T, 'Bivalent epigenetic modifications regulate PTGS2 expression during gestation in the amnion', Reproductive Sciences, San Diego, CA (2012) [E3]
Co-authors Gemma Madsen
2012 Welsh TN, Paul JW, Palliser HK, Hirst JJ, Mesiano S, Zakar T, 'PGDH expression decreases at term before labor onset in guinea pig fetal membranes', Reproductive Sciences, San Diego, CA (2012) [E3]
Co-authors Jonathan Paul, Hannah Palliser
2011 Mitchell CM, Sykes SD, Pringle KG, Lumbers ER, Hirst JJ, Bisits AJ, Zakar T, 'Methylation of CpG Islands in the promoters of proinflammatory and steroid receptor genes in the human amnion, decidua and placenta', Reproductive Sciences, Miami Beach, Florida (2011) [E3]
Co-authors Kirsty Pringle
2011 Palliser HK, Welsh TN, Zakar T, Symonds IM, Hirst JJ, 'Changes to the balance of prostaglandin synthesis and metabolism with intrauterine growth restriction contributes to preterm labour in the guinea pig', Reproductive Sciences, Miami Beach, Florida (2011) [E3]
Co-authors Ian Symonds, Hannah Palliser
2011 Kelleher MA, Hirst JJ, Palliser HK, 'A guinea pig model for the study of neuroactive steroid replacement in the preterm neonatal brain', Reproductive Sciences, Miami Beach, Florida (2011) [E3]
Co-authors Hannah Palliser
2011 Palliser HK, Welsh TN, Zakar T, Symonds IM, Hirst JJ, 'Intrauterine growth restriction leads to increased prostaglandin synthesis and reduced metabolism contributing to preterm labour in the guinea pig', Journal of Paediatrics and Child Health, Hobart, Tasmania (2011) [E3]
Co-authors Hannah Palliser, Ian Symonds
2010 Dyson RM, Kelleher MA, Palliser HK, Hirst JJ, Wright IM, 'The guinea pig as an animal model for studying microvascular function in the preterm neonate in early extrauterine life', 9th World Congress for Microcirculation. Final Program and Abstract Book, Paris, France (2010) [E3]
Co-authors Hannah Palliser, Ian Wright
2010 Welsh TN, Mesiano S, Hirst JJ, Zakar T, 'Decreased uterine progesterone receptor expression may explain functional progesterone withdrawal in the pregnant guinea pig', The Endocrine Society of Australia Annual Scientific Meeting Proceedings and Abstract Book, Sydney (2010) [E3]
2010 Dyson RM, Palliser HK, Kelleher MA, Hirst JJ, Wright IM, 'Preterm birth and intrauterine growth restriction: effect of microvascular function in the neonatal guinea pig', The Endocrine Society of Australia Annual Scientific Meeting Proceedings and Abstract Book, Sydney (2010) [E3]
Co-authors Ian Wright, Hannah Palliser
2010 Kelleher MA, Palliser HK, Hirst JJ, 'Premature birth results in ex utero brain development in a low neuroprotective steroid environment', The Endocrine Society of Australia Annual Scientific Meeting Proceedings and Abstract Book, Sydney (2010) [E3]
Co-authors Hannah Palliser
2010 Lumbers ER, Pringle KG, Marques FZ, Hirst JJ, Markus MA, Morris BJ, et al., 'Identification of renin-angiotensin system (RAS) in human fetal membranes, decidua and placenta and the effects of gender and labour', Hypertension, Dallas, TX (2010) [E3]
Co-authors Kirsty Pringle
2010 Kelleher MA, Palliser HK, Hirst JJ, 'Compromised neurosteroid biosynthesis in the preterm neonate', Journal of Paediatrics and Child Health: Abstracts of the 14th Annual Congress of the Perinatal Society of Australia and New Zealand 2010, Wellington, NZ (2010) [E3]
Co-authors Hannah Palliser
2010 Pringle KG, Zakar T, Hirst JJ, Lumbers ER, 'Evidence that the renin angiotensin system is involved in early placentation', Journal of Paediatrics and Child Health: Abstracts of the 14th Annual Congress of the Perinatal Society of Australia and New Zealand 2010, Wellington, NZ (2010) [E3]
Co-authors Kirsty Pringle
2010 Marques FZ, Pringle KG, Markus MA, Conquest AL, Hirst JJ, Sarris M, et al., 'Molecular characterization of renin-angiotensin system components in human intrauterine tissues and fetal membranes from vaginal delivery and cesarean section', Reproduction, Fertility and Development, Sydney (2010) [E3]
DOI 10.1016/j.placenta.2010.12.006
Co-authors Kirsty Pringle
2009 Lumbers ER, Pringle KG, Roach DM, Mitchell CM, Hirst JJ, Markus A, et al., 'The identification and role of the intrauterine (Pro)renin/(Pro)renin receptor angiotensin system in prostaglandin synthesis in pregnancy', Reproductive Sciences, Glasgow, Scotland (2009) [E3]
Co-authors Kirsty Pringle
2009 McKendry AA, Palliser HK, Walker DW, Hirst JJ, 'The effect of betamethasone treatment on peripheral eurosteroidogenesis in a guinea pig model of growth restriction', Reproductive Sciences, Glasgow, Scotland (2009) [E3]
Co-authors Hannah Palliser
2009 Pringle KG, Hirst JJ, Mitchell CM, Zakar T, Lumbers ER, 'The mechanism of prorenin induced PGHS-2 expression in the amnion', Reproductive Sciences, Glasgow, Scotland (2009) [E3]
Co-authors Kirsty Pringle
2009 Gibson KJ, Wang Y, Boyce AC, Palliser HK, Hirst JJ, Lumbers ER, 'Effects of intrauterine growth restriction on the intrarenal renin angiotensin system in the neonatal guinea pig', Journal of Paediatrics and Child Health, Darwin, NT (2009) [E3]
DOI 10.1111/j.1440-1754.2009.01474.x
Co-authors Hannah Palliser
2009 Kelleher MA, Palliser HK, Walker DW, Hirst JJ, 'Effect of intrauterine growth restriction and pharmacologic inhibition of 5alpha-reductase on enzyme expression in the fetal cerebellum', Journal of Paediatrics and Child Health, Darwin, NT (2009) [E3]
DOI 10.1111/j.1440-1754.2009.01475.x
Co-authors Hannah Palliser
2009 McKendry AA, Palliser HK, Walker DW, Hirst JJ, 'Effect of betamethasone treatment on steroidogenic enzyme expression in growth restricted fetal guinea pigs', Journal of Paediatrics and Child Health, Darwin, NT (2009) [E3]
DOI 10.1111/j.1440-1754.2009.01475.x
Co-authors Hannah Palliser
2009 Palliser HK, Zakar T, Hirst JJ, 'Effect of growth restriction on myometrial progesterone receptor expression near term', Journal of Paediatrics and Child Health, Darwin, NT (2009) [E3]
DOI 10.1111/j.1440-1754.2009.01474.x
Co-authors Hannah Palliser
2009 Roach DM, Hirst JJ, Palliser HK, 'Effect of IUGR and sex on PR expression in the fetal guinea pig brain', Journal of Paediatrics and Child Health, Darwin, NT (2009) [E3]
DOI 10.1111/j.1440-1754.2009.01475.x
Co-authors Hannah Palliser
2009 Pringle KG, Hirst JJ, Conquest AL, Mitchell CM, Zakar T, Lumbers ER, 'The role of prorenin in amnion PGHS-2 expression and the induction of labour', Journal of Paediatrics and Child Health, Darwin, NT (2009) [E3]
DOI 10.1111/j.1440-1754.2009.01474.x
Co-authors Kirsty Pringle
2008 Kelleher MA, Palliser HK, Roach DM, Sullivan RK, Walker DW, Hirst JJ, 'Effect of 5 alpha-reductase inhibition on apoptotic brain cell death and the expression of neurosteroidogenic enzymes in the fetal and neonatal guinea pig', Journal of Paediatrics and Child Health, Gold Coast, QLD (2008) [E3]
DOI 10.1111/j.1440-1754.200801297.x
Co-authors Hannah Palliser
2008 McKendry AA, Palliser HK, Roach DM, Sullivan RK, Walker DW, Hirst JJ, 'Repeated exposure to betamethasone increases brain cell death and suppresses neurosteroidogenic pathways in the growth restricted guinea pig fetus', Journal of Paediatrics and Child Health, Gold Coast, QLD (2008) [E3]
DOI 10.1111/j.1440-1754.200801297.x
Co-authors Hannah Palliser
2008 Roach DM, Lumbers ER, Mitchell CM, Hirst JJ, Zakar T, 'The identification of the intrauterine (pro)renin/(pro)renin receptor system and its role in prostaglandin synthesis in pregnancy and labour', Journal of Paediatrics and Child Health, Gold Coast, QLD (2008) [E3]
DOI 10.1111/j.1440-1754.200801297.x
2008 Lumbers ER, Roach DM, Mitchell CM, Hirst JJ, Zakar T, 'The identification and role of the intrauterine (pro) renin/(pro)renin receptor system in prostaglandin synthesis in pregnancy', Reproductive Sciences, San Diego, CA (2008) [E3]
2008 McKendry AA, Palliser HK, Roach DM, Sullivan RK, Walker DW, Hirst JJ, 'Effect of betamethasone treatment on brain cell death and neurosteroidogenic pathways in a guinea pig model of growth restriction', Reproductive Sciences, San Diego, CA (2008) [E3]
Co-authors Hannah Palliser
2008 Kelleher MA, Palliser HK, Roach DM, Sullivan RK, Walker DW, Hirst JJ, 'Effect of inhibition of 5 alpha reduced steroid synthesis on apoptotic brain cell death and neurosteroidogenic enzyme expression in the fetal and neonatal guinea pig', Reproductive Sciences, San Diego, CA (2008) [E3]
Co-authors Hannah Palliser
2008 Sullivan RK, Palliser HK, McKendry AA, Roach DM, Walker DW, Hirst JJ, 'Effect of betemethasone treatment on apoptotic cell death and neurosteriodogenic pathways in a guinea pig model of growth restriction', 2008 Neuroscience Meeting Planner, Washington, DC (2008) [E3]
Co-authors Hannah Palliser
2008 Mitchell CM, Hubbard SA, Hirst JJ, Giles WB, Zakar T, 'Chronic suppression of prostaglandin endoperoxide H synthase (PGHS-2) expression in the human amnion by glucocorticoids in vivo', 51st Annual Scientific Meeting of the Endocrine Society of Australia and Society of Reproductive Biology: Meeting Proceedings and Abstract Book, 51st Annual Scientific Meeting of the Endocrine So (2008) [E3]
2008 Pringle KG, Roach DM, Mitchell CM, Hirst JJ, Zakar T, Lumbers ER, 'The intrauterine (pro)renin/(pro)renin receptor system and its role in prostaglandin synthesis during pregnancy', 51st Annual Scientific Meeting of the Endocrine Society of Australia and Society of Reproductive Biology: Meeting Proceedings and Abstract Book, Melbourne, VIC (2008) [E3]
Co-authors Kirsty Pringle
2008 Smith AT, Palliser HK, Zakar T, Dunstan RH, Hirst JJ, 'Neurosteroid profiles in fetal, maternal and neonatal guinea pigs using gas chromatography-mass spectrometry', The Twenty-Second Fetal and Neonatal Workshop of Australia and New Zealand Abstract Book, Runaway Bay, QLD (2008) [E3]
Co-authors Hugh Dunstan, Hannah Palliser
2008 Zakar T, Hirst JJ, Mitchell CM, 'Glucocorticoid regulation of prostaglandin synthesis in the human fetal membranes: Duality in the style of Dr. Jekyll and Mr. Hyde?', The Twenty-Second Fetal and Neonatal Workshop of Australia and New Zealand Abstract Book, Runaway Bay, QLD (2008) [E3]
2007 Yawno T, Castillo-Melendez M, Walker D, Hirst JJ, 'Neuroprotective role for allopregnanolone on cerebellar purkinje cells in fetal sheep (Poster)', 7th IBRO 2007 World Congress of Neuroscience Program, Melbourne (2007) [E3]
2007 Smith AT, Palliser HK, Hirst JJ, 'Measurement of neurosteroids in the fetal and neonatal guinea pig brain using gas chromatography-mass spectrometry', Fetal & Neonatal Workshop of Australia and New Zealand 21st Annual Meeting. Abstracts, Melbourne, VIC (2007) [E3]
Co-authors Hannah Palliser
2007 Palliser HK, Roach DM, Walker DW, Hirst JJ, 'Expression of 5aReductase enzymes in the fetal guinea pig brain and placenta following intrauterine growth restriction', Reproductive Sciences (Scientific Program & Abstracts: 54th Annual Meeting, SGI), Reno, Nevada (2007) [E3]
Co-authors Hannah Palliser
2007 Roach DM, Palliser HK, Walker DW, Hirst JJ, 'Expression of 5aReductase enzymes in uterine tissues at term and following labor', Reproductive Sciences (Scientific Program & Abstracts: 54th Annual Meeting, SGI), Reno, Nevada (2007) [E3]
Co-authors Hannah Palliser
2007 Palliser HK, Roach DM, Walker DW, Hirst JJ, 'Effect of intrauterine growth restriction on the expression of 5alpha reductase in the fetal guinea pig brain and placenta', Satellite Conference of DOHaD 2007 (5th World Congress of Developmental Origins of Health and Disease), Melbourne, VIC (2007) [E3]
Co-authors Hannah Palliser
2006 Yawno T, Yan EB, Walker DW, Hirst JJ, 'Inhibition of neurosteroid synthesis increases asphyxia-induced brain injury in the late gestation fetal sheep', Journal of the Society for Gynecologic Investigation (Vol. 13, no. 2: 31) Scientific Program and Abstracts 53rd Annual Meeting - March 22-25, 2006 Toronto, Ontario, Toronto, Canada (2006) [E3]
2006 Hirst JJ, Westcott KT, Ciurej I, Walker DW, Wlodek ME, 'Neurosteroids in the brain of growth restricted fetal and newborn rats (Poster presentation)', Journal of the Society for Gynecologic Investigation (Vol. 13, no. 2: 729) Scientific Program and Abstracts 53rd Annual Meeting - March 22-25, 2006 Toronto, Ontario, Toronto, Ontario (2006) [E3]
2006 Saglam B, Yan EB, Hirst JJ, Walker DW, 'Maternal infusion of the COX-2 inhibitor, nimesulide, suppresses normal and asphyxia-induced apoptotic cell death in the fetal hippocampus (Poster presentation)', Journal of the Society for Gynecologic Investigation (Vol. 13, no. 2: 729) Scientific Program and Abstracts 53rd Annual Meeting - March 22-25, 2006 Toronto, Ontario, Toronto, Ontario (2006) [E3]
2006 Hirst JJ, Westcott KT, Ciurej I, Walker DW, Wlodek ME, 'Neurosteroids in the brain of growth restricted fetal and newborn rats.', JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION, Toronto, CANADA (2006)
2005 Palliser HK, Hirst JJ, Rice GE, Dellios NL, Escalona RM, Ooi GT, Young IR, 'The NF kappa B inhibitor, sulfasalazine, suppresses uterine activity by a PGHS- independent pathway.', JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION, Los Angeles, CA (2005)
Co-authors Hannah Palliser
2004 Palliser HK, Dellios N, Escalona R, Rice GE, Hirst JJ, Young IR, '2004 Changes in prostaglandin receptor expression in the amnion and cervix following preterm and term labour', Endocrine Society of Australian 47th Annual Meeting, Not Known (2004) [E3]
Co-authors Hannah Palliser
2004 Palliser HK, Hirst JJ, Rice GE, Dellios NL, Escalona RM, Ooi GT, Young IR, 'Expression of prostaglandin E and F receptors in ovine gestational tissues at labour onset', Perinatal Society of Australia and New Zealand 7th Annual Meeting, Not Known (2004) [E3]
Co-authors Hannah Palliser
2004 Palliser HK, Hirst JJ, Rice GE, Dellios NL, Escalona RM, Ooi GT, Young IR, 'Increase in the expression of prostaglandin F synthase in ovine gestational tissues at labor onset.', JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION, Houston, TX (2004)
Co-authors Hannah Palliser
2004 Hirst JJ, Young IR, Palliser HK, Peri KG, Zaragoza DB, Olson DM, 'Delay of preterm birth in sheep by THG113.31, a prostaglandin (PG)F-2 alpha receptor (FP) antagonist: Electromyographic activity (EMG), blood gases, and PGs.', JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION, Houston, TX (2004)
Co-authors Hannah Palliser
2004 Parkington HC, Hirst JJ, Young IR, Palliser HK, Palliser DM, 'THG-113, a prostaglandin F2a (PGF2a) receptor antagonist suppresses the sensitivity to maximal contractile activity evoked by exogenous PGF2a in isolated sheep myometrium', Society for Gynecologic Investigation 51st Annual Meeting, Not Known (2004) [E3]
Co-authors Hannah Palliser
2004 Palliser HK, Dellios N, Escalona R, Ooi G, Rice GE, Hirst JJ, '2004 Prostaglandin F and E synthases in ovine myometrium, endometrium and placenta during at labour onset', Society for Gynecologic Investigation 51st Annual Meeting, Not Known (2004) [E3]
Co-authors Hannah Palliser
2004 Hirst JJ, Young IR, Palliser HK, Peri KG, Zaragoza DB, Olson DM, '2004 delay of preterm birth in sheep by THG-113, a prostaglandin F2a receptor antagonist: electromyographic activity, blood gases and PGs', Society for Gynecologic investigation 51st annual meeting, Not Known (2004) [E3]
Co-authors Hannah Palliser
2003 Billiards SS, Wilkinson VE, Walker DW, Canny BJ, Hirst JJ, 'Deoxyxorticosterone: its role in the stress response in newborn lambs', Proceedings of the 6th Annual Meeting, Perinatal Society of Australia and New Zealand, Christchurch New Zealand (2003) [E3]
2003 Nguyen PN, Young IR, Walker DW, Hirst JJ, 'Neurosteroids in the brain of fetal sheep after hypophysectomy or adrenalectomy' (2003) [E3]
2003 Olson DM, Grisby PL, Peri K, Hirst JJ, 'A specific antagonist of the prostaglandin (PG) F2a receptor, THG113.31a, delays preterm labour induced by RU486 in sheep' (2003) [E3]
2003 Renda A, Pallister H, Hirst JJ, Young IR, Kemp B, Hoffman P, Rice GE, 'Identification of novel labour-associated proteins in cervico-vaginal fluid' (2003) [E3]
2003 Nguyen PN, Yan EB, Scott KM, Castillo-Melendez M, Walker DW, Hirst JJ, 'Umbilical cord occlusion althers 5a-pregnane steroid content in the brain, adrenal and plasma of ovine fetuses' (2003) [E3]
2003 Nguyen PN, Young IR, Walker DW, Hirst JJ, 'P450scc/5a-reductase expression and neurosteroid content in the brain after hypophysectomy or adrenalectomy' (2003) [E3]
2003 Scott KM, Cassaglia P, Nguyen PN, Walker DW, Hirst JJ, 'Excitatory neurosteroids in the fetal and newborn brain: ontogenic changes and effects of chronic intrauterine hypoxaemia' (2003) [E3]
2003 Nguyen PN, Billards SS, Walker DW, Hirst JJ, 'Changes in allopregnanolone concentrations and neurosteroidogenic enzyme expression in the IUGR fetus' (2003) [E3]
2003 Palliser HK, Dellios N, Escalona R, Ooi G, Rice GE, Hirst JJ, Young IR, 'Prostaglandin synthetic enzymes in the ovine myometrium, endometrium and placenta during induced-preterm and spontaneous' (2003) [E1]
2003 Nguyen PN, Walker DW, Castillo-Melendez M, Hirst JJ, 'Changes in allopregnanolone concentrations and neurosteroidogenic enzyme expression in the compromised fetus' (2003) [E3]
2003 Nguyen PN, Young IR, Walker DW, Hirst JJ, 'Increased allopregnanolone concentrations in the fetal brain following umbilical cord occlusion' (2003) [E3]
2002 Nguyen PN, Billiards SS, Hirst JJ, Walker DW, '5 -reductase expression and allopregnanolone concentrations in the fetal an neonatal brain' (2002) [E3]
2002 Nguyen PN, Walker DW, Hirst JJ, 'Hypoxia alters neuroactive steroid production in the fetal brain' (2002) [E3]
2001 Billiards SS, Walker DW, Canny BJ, Hirst JJ, 'Neuroactive steroid and behavioural responses to endotoxin treatment in newborn lambs' (2001) [E3]
2001 Gigsby PL, Hirst JJ, Phillips DJ, Scheerlink JP, Jenkin G, 'Responses to intra-amniotic administration of endotoxin in late gestation sheep' (2001) [E3]
2001 Billards SS, Walker DW, Hirst JJ, 'Effect of endotoxin treatment on sleep and arousal in newborn lambs: a link between infection and SIDS' (2001) [E3]
1995 HIRST JJ, TEIXEIRA FJ, ZAKAR T, OLSON DM, 'PROSTAGLANDIN-H SYNTHASE-2 EXPRESSION INCREASES IN HUMAN GESTATIONAL TISSUES WITH SPONTANEOUS LABOR ONSET', REPRODUCTION FERTILITY AND DEVELOPMENT, HAMILTON ISL, AUSTRALIA (1995)
DOI 10.1071/RD9950633
Citations Scopus - 34Web of Science - 34
1993 OLSON DM, ZAKAR T, TEIXEIRA F, HIRST J, GUO F, PANKOVICH J, 'PROSTAGLANDINS AND PARTURITION', PROGRESS IN ENDOCRINOLOGY, NICE, FRANCE (1993)
Citations Web of Science - 1
1993 TEIXEIRA FJ, ZAKAR T, HIRST J, GUO F, MACHIN G, OLSON DM, 'PROSTAGLANDIN ENDOPEROXIDE-H SYNTHASE (PGHS) ACTIVITY INCREASES WITH GESTATION AND LABOR IN HUMAN AMNION', JOURNAL OF LIPID MEDIATORS, MONTREAL, CANADA (1993)
Citations Web of Science - 12
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Grants and Funding

Summary

Number of grants 30
Total funding $6,512,444

Click on a grant title below to expand the full details for that specific grant.


20153 grants / $1,606,249

Perinatal stress leads to neurosteroid deficits and adverse behavioural outcomes$1,151,520

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Jon Hirst, Associate Professor David Walker, Doctor Hannah Palliser, Professor Deborah Hodgson
Scheme Project Grant
Role Lead
Funding Start 2015
Funding Finish 2015
GNo G1400014
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Epigenetic regulation of inflammatory genes in the fetal membranes: role in term and preterm birth$452,729

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Tam Zakar, Professor Jon Hirst, Professor Murray Mitchell
Scheme Project Grant
Role Investigator
Funding Start 2015
Funding Finish 2015
GNo G1400158
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

8th International Congress on Steroid and the Nervous System, Turin Italy, 14-18 February 2015$2,000

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Professor Jon Hirst
Scheme Travel Grant
Role Lead
Funding Start 2015
Funding Finish 2015
GNo G1500317
Type Of Funding Internal
Category INTE
UON Y

20142 grants / $47,512

Progesterone therapy for preterm labour - evaluation of effects on fetal neuroactive steroid profiles$27,512

Funding body: John Hunter Hospital Charitable Trust Fund

Funding body John Hunter Hospital Charitable Trust Fund
Project Team Professor Jon Hirst, Professor Ian Symonds, Doctor Hannah Palliser
Scheme Research Grant
Role Lead
Funding Start 2014
Funding Finish 2014
GNo G1400122
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Stress in pregnancy and poor neurodevelopmental outcomes in children: the role of miRNA in regulating neurosteroid dysfunction$20,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Hannah Palliser, Professor Jon Hirst
Scheme Project Grant
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1401439
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

20132 grants / $673,952

Disrupted neurosteroid synthesis mediates the adverse effects of prenatal stress$671,952

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Jon Hirst, Associate Professor David Walker, Dr Mary Tolcos
Scheme Project Grant
Role Lead
Funding Start 2013
Funding Finish 2013
GNo G1200177
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Steroid and the Nervous System 7th Int Meeting, Italy 16-20 March 2013.$2,000

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Professor Jon Hirst
Scheme Travel Grant
Role Lead
Funding Start 2013
Funding Finish 2013
GNo G1300745
Type Of Funding Internal
Category INTE
UON Y

20122 grants / $44,454

Disruption of gestational neurosteroid concentrations by stressful events leads to adverse neurodevelopmental and behavioural outcomes in children form these pregnancies$34,454

Funding body: John Hunter Hospital Charitable Trust Fund

Funding body John Hunter Hospital Charitable Trust Fund
Project Team Professor Jon Hirst, Professor Ian Symonds, Doctor Hannah Palliser
Scheme Research Grant
Role Lead
Funding Start 2012
Funding Finish 2012
GNo G1200176
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Precellys Tissue Homogeniser$10,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Roger Smith, Professor Eugenie Lumbers, Conjoint Professor Tam Zakar, Professor Jon Hirst, Conjoint Professor Ian Wright, Doctor Gemma Madsen, Doctor Kaushik Maiti
Scheme Equipment Grant
Role Investigator
Funding Start 2012
Funding Finish 2012
GNo G1100979
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

20112 grants / $616,572

Pathways of neurosteroid-mediated protection following compromised pregnancy and preterm birth$547,415

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Jon Hirst, Associate Professor David Walker, Associate Professor Helena Parkington
Scheme Project Grant
Role Lead
Funding Start 2011
Funding Finish 2011
GNo G1000246
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Research microscope, confocal ready nikon eclipse 90i microscope$69,157

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Roger Smith, Conjoint Professor Tam Zakar, Professor Jon Hirst, Doctor Kaushik Maiti, Doctor Gemma Madsen, Professor Rodney Scott, Conjoint Professor Peter Wark, Laureate Professor Paul Foster, Professor Phil Hansbro, Conjoint Professor Ian Wright
Scheme Equipment Grant
Role Investigator
Funding Start 2011
Funding Finish 2011
GNo G1100024
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

20101 grants / $23,025

Investigation of IUGR-associated preterm labour using a guinea pig model$23,025

Funding body: John Hunter Hospital Charitable Trust Fund

Funding body John Hunter Hospital Charitable Trust Fund
Project Team Doctor Hannah Palliser, Professor Jon Hirst, Professor Ian Symonds
Scheme Research Grant
Role Investigator
Funding Start 2010
Funding Finish 2010
GNo G1000119
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

20093 grants / $556,179

Mechanisms of escape from progesterone-induced suppression: Role in normal and preterm birth$526,500

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Tam Zakar, Professor Jon Hirst
Scheme Project Grant
Role Investigator
Funding Start 2009
Funding Finish 2009
GNo G0188872
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Leica VT1200S - Fully automated vibrating blade microtome$16,209

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Robert Callister, Professor Alan Brichta, Conjoint Professor Keith Jones, Professor Jon Hirst, Doctor Brett Graham, Associate Professor Philip Bolton, Doctor Phil Jobling, Associate Professor Paul Tooney, Doctor Angela McPherson, Doctor Rebecca Lim, Doctor Ramatis De Oliveira, Mr Matthew Walsh
Scheme Equipment Grant
Role Investigator
Funding Start 2009
Funding Finish 2009
GNo G0189842
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

i-STAT 1 Blood Gas Analyser and Softron BP-98E$13,470

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Ian Wright, Professor Jon Hirst, Professor Eugenie Lumbers, Conjoint Professor Tam Zakar, Doctor Hannah Palliser
Scheme Equipment Grant
Role Investigator
Funding Start 2009
Funding Finish 2009
GNo G0189843
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

20083 grants / $493,558

The role of the intrauterine (pro) renin/(pro)renin receptor system in prostaglandin synthesis in pregnancy$468,750

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Eugenie Lumbers, Conjoint Professor Tam Zakar, Professor Jon Hirst, Professor Brian Morris
Scheme Project Grant
Role Investigator
Funding Start 2008
Funding Finish 2008
GNo G0187618
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Does fetal growth restriction increase uterine activity and upregulate labour associated genes preterm?$15,208

Funding body: John Hunter Hospital Charitable Trust Fund

Funding body John Hunter Hospital Charitable Trust Fund
Project Team Professor Jon Hirst, Doctor Hannah Palliser, Professor Ian Symonds
Scheme Research Grant
Role Lead
Funding Start 2008
Funding Finish 2008
GNo G0189368
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

LED fluorescence illuminators and filter set (525nm + 575DF20) for LAS3000 image analysis system$9,600

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Roger Smith, Professor Ian Symonds, Conjoint Associate Professor Andrew Bisits, Conjoint Professor Tam Zakar, Doctor John Fitter, Doctor Cheng Chan, Conjoint Associate Professor Rick Nicholson, Doctor Giavanna Angeli, Doctor Kaushik Maiti, Doctor Jonathan Paul, Professor Jon Hirst, Doctor Hannah Palliser, Professor Eugenie Lumbers
Scheme Equipment Grant
Role Investigator
Funding Start 2008
Funding Finish 2008
GNo G0188543
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

20075 grants / $488,161

Neurosteroid mediated protection after birth: approaches for maximising protective steroid levels in the neonatal brain$433,625

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Jon Hirst, Associate Professor David Walker
Scheme Project Grant
Role Lead
Funding Start 2007
Funding Finish 2007
GNo G0186424
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Beta Radiation Counter Instrument facility$25,670

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Roger Smith, Conjoint Associate Professor Vicki Clifton, Conjoint Professor Tam Zakar, Conjoint Associate Professor Rick Nicholson, Dr Mark Read, Doctor Cheng Chan, Doctor John Fitter, Conjoint Associate Professor Andrew Bisits, Professor Jon Hirst, Doctor Hannah Palliser, Professor Ian Symonds
Scheme Equipment Grant
Role Investigator
Funding Start 2007
Funding Finish 2007
GNo G0188194
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

The hormonal regulation of birth$20,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Conjoint Professor Tam Zakar, Professor Jon Hirst
Scheme Near Miss Grant
Role Investigator
Funding Start 2007
Funding Finish 2007
GNo G0187183
Type Of Funding Internal
Category INTE
UON Y

Prostaglandin Transporters Controlling Prostaglandin Metabolism in the pregnant Uterus$7,166

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Conjoint Professor Tam Zakar, Professor Jon Hirst
Scheme Pilot Grant
Role Investigator
Funding Start 2007
Funding Finish 2007
GNo G0187886
Type Of Funding Internal
Category INTE
UON Y

4th IntMeeting on Steroids and the Nervous System, 17-21 February 2007$1,700

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Jon Hirst
Scheme Travel Grant
Role Lead
Funding Start 2007
Funding Finish 2007
GNo G0187374
Type Of Funding Internal
Category INTE
UON Y

20063 grants / $575,282

PRC - Priority Research Centre for Reproductive Science$544,282

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Laureate Professor John Aitken, Professor Roger Smith, Professor Eileen McLaughlin, Associate Professor Brett Nixon, Doctor Shaun Roman, Conjoint Associate Professor Vicki Clifton, Conjoint Professor Warwick Giles, Professor Jon Hirst, Conjoint Associate Professor Rick Nicholson, Professor Ian Symonds
Scheme Priority Research Centre
Role Investigator
Funding Start 2006
Funding Finish 2006
GNo G0186945
Type Of Funding Internal
Category INTE
UON Y

Neurosteroids in the neonatal brain: potential role in protecting against perinatal brain injury$16,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor Jon Hirst, Conjoint Associate Professor Vicki Clifton
Scheme Project Grant
Role Lead
Funding Start 2006
Funding Finish 2006
GNo G0186100
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Strategies for maintaining neurosteroid-mediate brain protection following compromised pregnancies.$15,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Jon Hirst
Scheme New Staff Grant
Role Lead
Funding Start 2006
Funding Finish 2006
GNo G0186743
Type Of Funding Internal
Category INTE
UON Y

20052 grants / $682,500

Contribution of disturbed blood flow and cerebral metabolism in white matter injury in the perinatal brain $366,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team
Scheme Unknown
Role Investigator
Funding Start 2005
Funding Finish 2007
GNo
Type Of Funding Not Known
Category UNKN
UON Y

Neuroactive Steroids in the developing brain: potential for preventing perinatal brain damage$316,500

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Jon Hirst
Scheme Project Grant
Role Lead
Funding Start 2005
Funding Finish 2005
GNo G0185607
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

20021 grants / $285,000

Mechanisms controlling prostaglandin synthesis and myometrial activation at labour onset$285,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team
Scheme Unknown
Role Investigator
Funding Start 2002
Funding Finish 2004
GNo
Type Of Funding Not Known
Category UNKN
UON Y

20011 grants / $420,000

Essential protective role of neuroactive steroids in the fetal and neonatal brain $420,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team
Scheme Unknown
Role Lead
Funding Start 2001
Funding Finish 2003
GNo
Type Of Funding Not Known
Category UNKN
UON Y
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Research Supervision

Number of supervisions

Completed13
Current10

Total current UON EFTSL

PhD2.85

Current Supervision

Commenced Level of Study Research Title / Program / Supervisor Type
2015 PhD Perinatal Stress and its Effect on Neurosteroid Levels and Behavioural Outcomes
Pharmacy, Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2015 PhD Epigenetic Regulation of Inflammatory Genes Involved in the Timing of Birth
Medical Studies, Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2014 PhD Neurosteroidogenesis, Neurodevelopment and Behaviour Following Preterm Birth: Effect of Prenatal and Postnatal Therapies
Pharmacy, Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2013 PhD Affect of Prenatal Insults on Long-Term Behaviour and Neurodevelopment; and Potential Neurosteroid Replacement Therapy
Pharmacy, Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2012 PhD The Effects of Maternal Stress on Perinatal Neurodevelopment and Behaviour
Pharmacy, Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2010 PhD Transcriptional and Epigenetic Regulation of Labour Associated Inflammatory Genes in the Amnion
Medical Studies, Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2007 Honours 5a-reductases enzymes with in the brain of compromised fetuses
Medical Science, University of Newcastle
Principal Supervisor
2007 Honours Effect of glucocorticoid treatment on neurosteroid synthesis and perinatal brain injury
Medical Science, University of Newcastle
Co-Supervisor
2007 Honours Expression of progesterone receptor isoforms in the guinea pig myometrium
Medical Science, University of Newcastle
Co-Supervisor
2004 PhD Development of steroid based neuroprotective therapies for the fetus and neonate
Medical Science, Monash University
Co-Supervisor

Past Supervision

Year Level of Study Research Title / Program / Supervisor Type
2012 PhD Potential Neurosteroid Replacement Therapy Following Premature Birth and Fetal Growth Restriction
Pharmacy, Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2010 Masters Betamethasone: A Neuroactive Steroid Deficit and Adverse Effects in the Brain?
Pharmacy, Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2007 PhD Regulation of prostaglandin synthesis and receptors during sponanious and induced ovine labour
Medical Science, Monash University
Co-Supervisor
2006 Honours Expression of 5a-reductases in the fetal brain and placenta
Accounting, University of Newcastle
Principal Supervisor
2006 Honours Mechanism for reducing perinatal brain injury
Medical Science, Monash University
Co-Supervisor
2004 PhD Role of neurosteroids in the fetal and newborn brain
Medical Science, Monash University
Principal Supervisor
2004 Honours Use of NFKB agonist in the treatment of preterm labour
Medical Science, Monash University
Co-Supervisor
2004 Honours Pregnenolone and pregnenolone sulphate in the fetal brain
Medical Science, Monash University
Co-Supervisor
2003 PhD Neurosteroids and somnogenic responses to endotoxin and hypoxia in lambs
Medical Science, Monash University
Principal Supervisor
2002 Honours Role of steroid sulphates in perinatal brain injury
Medical Science, Monash University
Co-Supervisor
2002 PhD Development of new strategies for teh inhibition of preterm labour
Medical Science, Monash University
Co-Supervisor
2000 PhD Steroids and GABAA receptors in the developing brain
Medical Science, Monash University
Principal Supervisor
1999 PhD Effects of pregnane steroids on behavioural parameters in fetal sheep
Medical Science, Monash University
Principal Supervisor
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Professor Jon Hirst

Position

Professor
Mothers and Babies Research Centre
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

Focus area

Pharmacy and Experimental Pharmacology

Contact Details

Email jon.hirst@newcastle.edu.au
Phone (02) 40420360
Mobile 0413961638
Fax (02) 4921 7903

Office

Room RM3407
Building HMRI
Location Callaghan
University Drive
Callaghan, NSW 2308
Australia
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