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Professor John Attia

Academic Director

School of Medicine and Public Health

Career Summary

Biography

Professor John Attia obtained a BSc in Physiology (Faculty scholar at McGill University) and then won a 5 year MRC scholarship to complete his MD/PhD in Molecular Genetics (University of Toronto). He trained at McMaster University (Canada) in general internal medicine and obtained his fellowship with the Royal College of Physicians of Canada and the Royal Australasian College of Physicians. During this time he was awarded the Outstanding Housestaff award, the J.T. Walsh award for outstanding Internal Medicine resident, and Best Teacher in Internal Medicine. During his residency, he also completed his MSc in Epidemiology (McMaster University). He has been listed on the NHMRC register of Evidence-Based Medicine experts and has provided epidemiological expertise to the Therapeutic Goods Administration. In 2012, he won the senior research excellence award from both the Faculty of Health (University of Newcastle) and the Hunter Medical Research Institute. 

Between 1999 and 2013, he has collaborated in obtaining $13.6 million in grant income and published over 250 manuscripts (with another 5 submitted); these have garnered over 3000 citations, leading to an h-index of 30 (Scopus data April 2013). He has also submitted 7 government reports, and 7 book chapters. He has been supervisor or co-supervisor to 20 PhD students (10 graduated and 10 current) and 6 Master’s students (5 graduated, 1 current). He is currently academic director of general medicine at John Hunter Hospital responsible for the foundation and running of the advanced training program for general physicians, one of the only fully supported such programs in the state. He is also co-director of the Clinical Research Design, IT, and Statistical Support (CReDITSS) Unit, a unit that provides methodological and analysis advice to clinical researchers.

Research Expertise
John's research expertise includes clinical, molecular, and genetic epidemiology methods. Clinical epidemiology covers such topics as population- and hospital-based observational studies (cohort, case-control, crossover) and controlled clinical trials as well as studies of diagnostic tests, meta-analyses, and health services research. Molecular epidemiology focuses mainly on evaluation of biomarkers. Genetic epidemiology covers design and analysis of genome-wide association studies of various complex diseases, particularly macular degeneration and stroke. 

Qualifications

  • PhD, University of Toronto
  • Bachelor of Science, McGill University - Canada
  • Master of Science, McMaster University - Canada
  • Doctor of Medicine, University of Toronto

Keywords

  • clinical epidemiology
  • genetic epidemiology
  • public health

Languages

  • French (Fluent)

Fields of Research

Code Description Percentage
010499 Statistics not elsewhere classified 15
110399 Clinical Sciences not elsewhere classified 45
111799 Public Health and Health Services not elsewhere classified 40

Professional Experience

UON Appointment

Title Organisation / Department
Professor University of Newcastle
School of Medicine and Public Health
Australia

Academic appointment

Dates Title Organisation / Department
1/01/2006 -  Epidemiology Expert to the Complementary Medicines Advisory Committee Therapeutic goods administration
Australia
1/01/2003 -  Evidence-based medicine expert to assist groups in developing EBM guidelines NHMRC (National Health & Medical Research Council)

Membership

Dates Title Organisation / Department
Member - Royal Australasian College of Physicians The Royal Australasian College of Physicians
Australia

Awards

Research Award

Year Award
2005 Dudley Homer Vose award
National Heart Foundation of Australia
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Book (5 outputs)

Year Citation Altmetrics Link
2004 D'Este CA, Byles JE, Attia JR, Brown AM, Second Mortality and Cancer Incidence Report, -, Newcastle, Australia (2004) [A2]
Co-authors Catherine Deste, Julie Byles
2004 D'Este CA, Byles JE, Attia JR, Brown AM, Report on the General Health and Medical Study, -, Newcastle, Australia, 463 (2004) [A2]
Co-authors Julie Byles, Catherine Deste
2003 D'Este CA, Byles JE, Attia JR, Brown AM, Literature Review Report, -, Newcastle, Australia (2003) [A2]
Co-authors Julie Byles, Catherine Deste
2003 D'Este CA, Byles JE, Attia JR, Brown AM, Report on the qualitative interviews, -, Newcastle, Australia (2003) [A2]
Co-authors Julie Byles, Catherine Deste
2003 D'Este CA, Byles JE, Attia JR, Brown AM, Interim mortality and cancer incidence report, -, Newcastle, Australia (2003) [A2]
Co-authors Catherine Deste, Julie Byles
Show 2 more books

Chapter (4 outputs)

Year Citation Altmetrics Link
2015 Riveros C, Vimieiro R, Holliday EG, Oldmeadow C, Wang JJ, Mitchell P, et al., 'Identification of genome-wide SNP-SNP and SNP-clinical Boolean interactions in Age-related Macular Degeneration', Epistasis: Methods and Protocols, Springer, New York 217-255 (2015) [B1]
DOI 10.1007/978-1-4939-2155-3_12
Citations Scopus - 1
Co-authors Pablo Moscato, Liz Holliday, Christopher Oldmeadow, Rodney Scott, Carlos Riveros
2013 Holliday EG, Oldmeadow CJ, Maguire JM, Attia JR, 'Candidate gene association studies in stroke', Stroke Genetics, Springer Verlag, London 9-23 (2013) [B1]
Citations Scopus - 1
Co-authors Jane Maguire, Christopher Oldmeadow, Liz Holliday
2011 Attia JR, 'Moving beyond sensitivity and specificity: Using likelihood ratios to help interpret diagnostic tests', Abnormal Laboratory Results, McGraw Hill, North Ryde, NSW 23-29 (2011) [B2]
2002 Jaeschke R, Guyatt G, Barratt A, Walter S, McAlister F, Attia JR, 'Part 2: Beyond the basics. Therapy and understanding the results. Measures of association', Users' guides to the medical literature : a manual for evidence-based clinical practice, AMA Press, Chicago, Ill. 706 (2002) [B2]
Show 1 more chapter

Journal article (409 outputs)

Year Citation Altmetrics Link
2016 Islam MR, Attia J, Ali L, McEvoy M, Selim S, Sibbritt D, et al., 'Zinc supplementation for improving glucose handling in pre-diabetes: A double blind randomized placebo controlled pilot study', Diabetes Research and Clinical Practice, 115 39-46 (2016)

© 2016 Elsevier Ireland Ltd. Aims: There are a number of studies showing that zinc supplementation may improve glucose handling in people with established diabetes. We sought to ... [more]

© 2016 Elsevier Ireland Ltd. Aims: There are a number of studies showing that zinc supplementation may improve glucose handling in people with established diabetes. We sought to investigate whether this zinc-dependent improvement in glucose handling could potentially be harnessed to prevent the progression of pre-diabetes to diabetes. In this double-blind randomized placebo-controlled trial, we determined participants' fasting blood glucose levels, (FBG) and Homeostasis Model Assessment (HOMA) parameters (beta cell function, insulin sensitivity and insulin resistance) at baseline and after 6 months of zinc supplementation. Methods: The Bangladesh Institute of Health Sciences Hospital (BIHS) (Mirpur, Dhaka, Bangladesh) database was used to identify 224 patients with prediabetes, of whom 55 met the inclusion criteria and agreed to participate. The participants were randomized either to the intervention or control group using block randomization. The groups received either 30 mg zinc sulphate dispersible tablet or placebo, once daily for six months. Results: After six months, the intervention group significantly improved their FBG concentration compared to the placebo group (5.37 ± 0.20 mmol/L vs 5.69 ± 0.26, p < 0.001) as well as compared to their own baseline (5.37 ± 0.20 mmol/L vs 5.8 ± 0.09, p < 0.001). Beta cell function, insulin sensitivity and insulin resistance all showed a statistically significant improvement as well. Conclusion: To our knowledge this is the first trial to show an improvement in glucose handling using HOMA parameters in participants with prediabetes. Larger randomized controlled trials are warranted to confirm these findings and to explore clinical endpoints.

DOI 10.1016/j.diabres.2016.03.010
Co-authors Milton Hasnat, Roseanne Peel, Mark Mcevoy
2016 Bolton KA, Avery-Kiejda KA, Holliday EG, Attia J, Bowden NA, Scott RJ, 'A polymorphic repeat in the IGF1 promoter influences the risk of endometrial cancer.', Endocr Connect, (2016)
DOI 10.1530/EC-16-0003
Co-authors Liz Holliday, Kelly Kiejda, Nikola Bowden
2016 Ashman AM, Collins CE, Weatherall L, Brown LJ, Rollo ME, Clausen D, et al., 'A cohort of Indigenous Australian women and their children through pregnancy and beyond: the Gomeroi gaaynggal study.', J Dev Orig Health Dis, 1-12 (2016)
DOI 10.1017/S204017441600009X
Co-authors Kirsty Pringle, Roger Smith, Kym Rae, Megan Rollo, Clare Collins, Leanne Brown
2016 Gunathilake R, Oldmeadow C, McEvoy M, Inder KJ, Schofield PW, Nair BR, Attia J, 'The Association Between Obesity and Cognitive Function in Older Persons: How Much Is Mediated by Inflammation, Fasting Plasma Glucose, and Hypertriglyceridemia?', J Gerontol A Biol Sci Med Sci, (2016)
DOI 10.1093/gerona/glw070
Co-authors Kerry Inder, Peter Schofield, Christopher Oldmeadow, Mark Mcevoy
2016 Okbay A, Baselmans BM, De Neve JE, Turley P, Nivard MG, Fontana MA, et al., 'Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.', Nat Genet, (2016)
DOI 10.1038/ng.3552
Co-authors Christopher Oldmeadow, Liz Holliday
2016 Faulkner S, Roselli S, Demont Y, Pundavela J, Choquet G, Leissner P, et al., 'ProNGF is a potential diagnostic biomarker for thyroid cancer.', Oncotarget, (2016)
DOI 10.18632/oncotarget.8652
Co-authors Marjorie Walker, Hubert Hondermarck, Christopher Oldmeadow
2016 Pattaro C, Teumer A, Gorski M, Chu AY, Li M, Mijatovic V, et al., 'Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function.', Nat Commun, 7 10023 (2016)
DOI 10.1038/ncomms10023
Co-authors Mark Mcevoy, Rodney Scott, Liz Holliday
2016 Anne S, Tse R, Oldmeadow C, Attia JR, Cala AD, 'Immersion of Bovine Eyeballs After 1 Hour in Seawater Does Not Result in Elevation of Postmortem Vitreous Humor Sodium and Chloride Levels.', Am J Forensic Med Pathol, 37 108-111 (2016)
DOI 10.1097/PAF.0000000000000229
Co-authors Christopher Oldmeadow
2016 Kepreotes E, Whitehead B, Lee M, Collison A, Goddard B, Cheese L, et al., 'HIGH-FLOW OXYGEN COMPARED TO STANDARD NASAL CANNULA OXYGEN DOES NOT REDUCE THE MEDIAN TIME ON OXYGEN FOR INFANTS WITH MODERATE BRONCHIOLITIS', RESPIROLOGY, 21 52-52 (2016)
Co-authors Christopher Oldmeadow
2016 Mather KA, Thalamuthu A, Oldmeadow C, Song F, Armstrong NJ, Poljak A, et al., 'Genome-wide significant results identified for plasma apolipoprotein H levels in middle-aged and older adults.', Sci Rep, 6 23675 (2016)
DOI 10.1038/srep23675
Co-authors Rodney Scott, Liz Holliday, Peter Schofield, Christopher Oldmeadow, Mark Mcevoy
2016 Lai JS, Oldmeadow C, Hure AJ, McEvoy M, Byles J, Attia J, 'Longitudinal diet quality is not associated with depressive symptoms in a cohort of middle-aged Australian women', British Journal of Nutrition, 1-9 (2016)

Copyright © The Authors 2016 There is increasing evidence for the role of nutrition in the prevention of depression. This study aims to describe changes in diet quality over 12 y... [more]

Copyright © The Authors 2016 There is increasing evidence for the role of nutrition in the prevention of depression. This study aims to describe changes in diet quality over 12 years among participants in the Australian Longitudinal Study on Women¿s Health in relation to changes in depressive symptoms. Women born between 1946 and 1951 were followed-up for 12 years (2001¿2013). Dietary intake was assessed using the Dietary Questionnaire for Epidemiological Studies (version 2) in 2001, 2007 and every 2¿3 years after that until 2013. Diet quality was summarised using the Australian Recommended Food Score (ARFS). Depressive symptoms were measured using the ten-item Centre for Epidemiologic Depression Scale at every 2¿3-year intervals during 2001¿2013. Linear mixed models were used to examine trends in diet quality and its sub-components. The same model including time-varying covariates was used to examine associations between diet quality and depressive symptoms adjusting for confounders. Sensitivity analyses were carried out using the Mediterranean dietary pattern (MDP) index to assess diet quality. Minimal changes in overall diet quality and its sub-components over 12 years were observed. There was a significant association between baseline diet quality and depression (ß=-0·24, P=0·001), but this was lost when time-varying covariates were added (ß=-0·04, P=0·10). Sensitivity analyses showed similar performance for both ARFS and MDP in predicting depressive symptoms. In conclusion, initial associations seen when using baseline measures of diet quality and depressive symptoms disappear when using methods that handle time-varying covariates, suggesting that previous studies indicating a relationship between diet and depression may have been affected by residual confounding.

DOI 10.1017/S000711451500519X
Co-authors Christopher Oldmeadow, Mark Mcevoy, Julie Byles, Alexis Hure
2016 de Vries PS, Chasman DI, Sabater-Lleal M, Chen MH, Huffman JE, Steri M, et al., 'A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration.', Hum Mol Genet, 25 358-370 (2016)
DOI 10.1093/hmg/ddv454
Co-authors Liz Holliday, Christopher Oldmeadow, Rodney Scott, Mark Mcevoy
2016 Handley TE, Kay-Lambkin FJ, Baker AL, Lewin TJ, Kelly BJ, Inder KJ, et al., 'Investigation of a Suicide Ideation Risk Profile in People With Co-occurring Depression and Substance Use Disorder.', J Nerv Ment Dis, (2016)
DOI 10.1097/NMD.0000000000000473
Co-authors Terry Lewin, Kerry Inder, Amanda Baker, Brian Kelly
2016 Cheng TH, Thompson DJ, O'Mara TA, Painter JN, Glubb DM, Flach S, et al., 'Five endometrial cancer risk loci identified through genome-wide association analysis.', Nat Genet, (2016)
DOI 10.1038/ng.3562
Co-authors Mark Mcevoy, Liz Holliday
2016 White J, Magin P, Attia J, Sturm J, McElduff P, Carter G, 'Predictors of health-related quality of life in community-dwelling stroke survivors: a cohort study.', Fam Pract, (2016)
DOI 10.1093/fampra/cmw011
Co-authors Gregory Carter, Parker Magin
2016 Chen MM, O'Mara TA, Thompson DJ, Painter JN, Australian National Endometrial Cancer Study Group (ANECS), Attia J, et al., 'GWAS meta-analysis of 16 852 women identifies new susceptibility locus for endometrial cancer.', Hum Mol Genet, (2016)
DOI 10.1093/hmg/ddw092
Co-authors Mark Mcevoy, Liz Holliday
2016 Bhaskar S, Stanwell P, Bivard A, Spratt N, Walker R, Kitsos GH, et al., 'The influence of initial stroke severity on the likelihood of unfavourable clinical outcome and death at 90 days following acute ischemic stroke: A tertiary hospital stroke register study', Neurology India, In press (2016)
Co-authors Mark Parsons, Chris Levi, Peter Stanwell, Neil Spratt
2016 Paul CL, Ryan A, Rose S, Attia JR, Kerr E, Koller C, Levi CR, 'How can we improve stroke thrombolysis rates? A review of health system factors and approaches associated with thrombolysis administration rates in acute stroke care', Implementation Science, 11 (2016)

© 2016 Paul et al. Background: Thrombolysis using intravenous (IV) tissue plasminogen activator (tPA) is one of few evidence-based acute stroke treatments, yet achieving high rat... [more]

© 2016 Paul et al. Background: Thrombolysis using intravenous (IV) tissue plasminogen activator (tPA) is one of few evidence-based acute stroke treatments, yet achieving high rates of IV tPA delivery has been problematic. The 4.5-h treatment window, the complexity of determining eligibility criteria and the availability of expertise and required resources may impact on treatment rates, with barriers encountered at the levels of the individual clinician, the social context and the health system itself. The review aimed to describe health system factors associated with higher rates of IV tPA administration for ischemic stroke and to identify whether system-focussed interventions increased tPA rates for ischemic stroke. Methods: Published original English-language research from four electronic databases spanning 1997-2014 was examined. Observational studies of the association between health system factors and tPA rates were described separately from studies of system-focussed intervention strategies aiming to increase tPA rates. Where study outcomes were sufficiently similar, a pooled meta-analysis of outcomes was conducted. Results: Forty-one articles met the inclusion criteria: 7 were methodologically rigorous interventions that met the Cochrane Collaboration Evidence for Practice and Organization of Care (EPOC) study design guidelines and 34 described observed associations between health system factors and rates of IV tPA. System-related factors generally associated with higher IV tPA rates were as follows: urban location, centralised or hub and spoke models, treatment by a neurologist/stroke nurse, in a neurology department/stroke unit or teaching hospital, being admitted by ambulance or mobile team and stroke-specific protocols. Results of the intervention studies suggest that telemedicine approaches did not consistently increase IV tPA rates. Quality improvement strategies appear able to provide modest increases in stroke thrombolysis (pooled odds ratio=2.1, p=0.05). Conclusions: In order to improve IV tPA rates in acute stroke care, specific health system factors need to be targeted. Multi-component quality improvement approaches can improve IV tPA rates for stroke, although more thoughtfully designed and well-reported trials are required to safely increase rates of IV tPA to eligible stroke patients.

DOI 10.1186/s13012-016-0414-6
Co-authors Chris Levi, Chris Paul
2016 Bhaskar S, Bivard A, Stanwell P, Parsons M, Attia J, Nilsson M, Levi C, 'Baseline collateral status and infarct topography in post-ischemic perilesional hyperperfusion: an arterial spin labelling (ASL) study', Journal of Cerebral Blood Flow and Metabolism, In press (2016)
Co-authors Peter Stanwell, Chris Levi
2016 Bhaskar S, Bivard A, Parsons M, Nilsson M, Attia JR, Stanwell P, Levi C, 'Delay of late-venous phase cortical vein filling in acute ischemic stroke patients: Associations with collateral status.', J Cereb Blood Flow Metab, (2016)
DOI 10.1177/0271678X16637611
Co-authors Peter Stanwell, Mark Parsons, Chris Levi
2016 Thompson DJ, O'Mara TA, Glubb DM, Painter JN, Cheng T, Folkerd E, et al., 'CYP19A1 fine-mapping and Mendelian randomization: Estradiol is causal for endometrial cancer', Endocrine-Related Cancer, 23 77-91 (2016)

© 2016 The authors. Candidate gene studies have reported CYP19A1 variants to be associated with endometrial cancerandwith estradiol (E2) concentrations.We analyzed2937singlenucle... [more]

© 2016 The authors. Candidate gene studies have reported CYP19A1 variants to be associated with endometrial cancerandwith estradiol (E2) concentrations.We analyzed2937singlenucleotidepolymorphisms (SNPs) in 6608 endometrial cancer cases and 37 925 controls and report the first genome widesignificant association between endometrial cancer and a CYP19A1 SNP (rs727479 in intron 2, P=4.8×10-11). SNP rs727479 was also among those most strongly associated with circulating E2 concentrations in 2767 post-menopausal controls (P=7.4×10-8). The observed endometrial cancer odds ratio per rs727479 A-allele (1.15, CI=1.11-1.21) is compatible with that predicted by theobservedeffectonE2 concentrations (1.09, CI=1.03-1.21), consistentwith the hypothesis that endometrial cancer risk is driven by E2. From 28 candidate-causal SNPs, 12 co-located with three putative gene-regulatory elements and their risk alleles associated with higher CYP19A1 expression in bioinformatical analyses. For both phenotypes, the associationswith rs727479 were stronger amongwomen with a higher BMI (PinteractionZ0.034 and 0.066 respectively), suggesting a biologically plausible gene-environment interaction.

DOI 10.1530/ERC-15-0386
Co-authors Mark Mcevoy, Rodney Scott, Liz Holliday
2016 Paterson MA, Smart CEM, Lopez PE, Mcelduff P, Attia J, Morbey C, King BR, 'Influence of dietary protein on postprandial blood glucose levels in individuals with Type¿1 diabetes mellitus using intensive insulin therapy', Diabetic Medicine, 33 592-598 (2016)

© 2016 Diabetes UK. Aim: To determine the effects of protein alone (independent of fat and carbohydrate) on postprandial glycaemia in individuals with Type¿1 diabetes mellitus u... [more]

© 2016 Diabetes UK. Aim: To determine the effects of protein alone (independent of fat and carbohydrate) on postprandial glycaemia in individuals with Type¿1 diabetes mellitus using intensive insulin therapy. Methods: Participants with Type¿1 diabetes mellitus aged 7-40¿years consumed six 150¿ml whey isolate protein drinks [0¿g (control), 12.5, 25, 50, 75 and 100] and two 150¿ml glucose drinks (10 and 20¿g) without insulin, in randomized order over 8¿days, 4¿h after the evening meal. Continuous glucose monitoring was used to assess postprandial glycaemia. Results: Data were collected from 27 participants. Protein loads of 12.5 and 50¿g did not result in significant postprandial glycaemic excursions compared with control (water) throughout the 300¿min study period (P¿>¿0.05). Protein loads of 75 and 100¿g resulted in lower glycaemic excursions than control in the 60-120¿min postprandial interval, but higher excursions in the 180-300¿min interval. In comparison with 20¿g glucose, the large protein loads resulted in significantly delayed and sustained glucose excursions, commencing at 180¿min and continuing to 5¿h. Conclusions: Seventy-five grams or more of protein alone significantly increases postprandial glycaemia from 3 to 5¿h in people with Type¿1 diabetes mellitus using intensive insulin therapy. The glycaemic profiles resulting from high protein loads differ significantly from the excursion from glucose in terms of time to peak glucose and duration of the glycaemic excursion. This research supports recommendations for insulin dosing for large amounts of protein.

DOI 10.1111/dme.13011
Citations Scopus - 1
Co-authors Bruce King
2016 Lai JS, Oldmeadow C, Hure AJ, McEvoy M, Hiles SA, Boyle M, Attia J, 'Inflammation mediates the association between fatty acid intake and depression in older men and women', Nutrition Research, 36 234-245 (2016)

© 2016 Elsevier Inc. Antioxidants and fatty acids are associated with depression and inflammation, and inflammation appears to predict depression risk; hence, the associations be... [more]

© 2016 Elsevier Inc. Antioxidants and fatty acids are associated with depression and inflammation, and inflammation appears to predict depression risk; hence, the associations between these nutrients and depression may be mediated by inflammation. We hypothesized that inflammatory markers interleukin (IL)-6 and C-reactive protein (CRP) mediate the associations between antioxidant and fatty acid intakes, and depression. Participants were from the Hunter Community Study, a longitudinal cohort of adults aged 55-85 years. Dietary intake was assessed using the Older Australian's Food Frequency Questionnaire. Fasting blood samples were drawn for analysis of nutrient and inflammatory biomarkers. Depressive symptoms were assessed using the 20-item Center for Epidemiologic Studies-Depression scale at baseline and at 5-year follow-up. Linear mixed models were used to investigate longitudinal associations between dietary intakes and depression, and mediation analyses were carried out to determine if IL-6 and/or CRP were the mediators. Analyses were conducted on men and women separately and adjusted for potential confounders. Fruit and monounsaturated fat intakes were negatively associated with depression, whereas total fat and saturated fat intakes were positively associated with depression in both sexes. Omega-3 polyunsaturated fat was inversely associated with depression in men only. IL-6 was a significant mediator of the association between fruits with low carotenoid content and depression in women. CRP significantly mediated the relationship between total fat, saturated fat, and monounsaturated fat intakes and depression in women, and saturated fat intake and depression in men. Our findings raise the possibility that the association between fatty acid intake and depression is partially mediated by inflammatory markers.

DOI 10.1016/j.nutres.2015.11.017
Co-authors Alexis Hure, Mark Mcevoy, Christopher Oldmeadow
2016 Ibrahim-Verbaas CA, Bressler J, Debette S, Schuur M, Smith AV, Bis JC, et al., 'GWAS for executive function and processing speed suggests involvement of the CADM2 gene', Molecular Psychiatry, 21 189-197 (2016)

© 2016 Macmillan Publishers Limited All rights reserved. To identify common variants contributing to normal variation in two specific domains of cognitive functioning, we conduct... [more]

© 2016 Macmillan Publishers Limited All rights reserved. To identify common variants contributing to normal variation in two specific domains of cognitive functioning, we conducted a genome-wide association study (GWAS) of executive functioning and information processing speed in non-demented older adults from the CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) consortium. Neuropsychological testing was available for 5429-32 070 subjects of European ancestry aged 45 years or older, free of dementia and clinical stroke at the time of cognitive testing from 20 cohorts in the discovery phase. We analyzed performance on the Trail Making Test parts A and B, the Letter Digit Substitution Test (LDST), the Digit Symbol Substitution Task (DSST), semantic and phonemic fluency tests, and the Stroop Color and Word Test. Replication was sought in 1311-21860 subjects from 20 independent cohorts. A significant association was observed in the discovery cohorts for the single-nucleotide polymorphism (SNP) rs17518584 (discovery P-value=3.12 × 10 -8) and in the joint discovery and replication meta-analysis (P-value=3.28 × 10 -9 after adjustment for age, gender and education) in an intron of the gene cell adhesion molecule 2 (CADM2) for performance on the LDST/DSST. Rs17518584 is located about 170 kb upstream of the transcription start site of the major transcript for the CADM2 gene, but is within an intron of a variant transcript that includes an alternative first exon. The variant is associated with expression of CADM2 in the cingulate cortex (P-value=4 × 10 -4). The protein encoded by CADM2 is involved in glutamate signaling (P-value=7.22 × 10 -15), gamma-aminobutyric acid (GABA) transport (P-value=1.36 × 10 -11) and neuron cell-cell adhesion (P-value=1.48 × 10 -13). Our findings suggest that genetic variation in the CADM2 gene is associated with individual differences in information processing speed.

DOI 10.1038/mp.2015.37
Co-authors Peter Schofield, Christopher Oldmeadow, Rodney Scott, Liz Holliday
2016 Malik R, Traylor M, Pulit SL, Bevan S, Hopewell JC, Holliday EG, et al., 'Low-frequency and common genetic variation in ischemic stroke: The METASTROKE collaboration.', Neurology, 86 1217-1226 (2016)
DOI 10.1212/WNL.0000000000002528
Co-authors Liz Holliday, Chris Levi
2016 Minelli C, Dean CH, Hind M, Alves AC, Amaral AFS, Siroux V, et al., 'Association of Forced Vital Capacity with the Developmental Gene NCOR2', PLoS ONE, 11 (2016)

© 2016 Minelli et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and re... [more]

© 2016 Minelli et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Background Forced Vital Capacity (FVC) is an important predictor of all-cause mortality in the absence of chronic respiratory conditions. Epidemiological evidence highlights the role of early life factors on adult FVC, pointing to environmental exposures and genes affecting lung development as risk factors for low FVC later in life. Although highly heritable, a small number of genes have been found associated with FVC, and we aimed at identifying further genetic variants by focusing on lung development genes. Methods Per-allele effects of 24,728 SNPs in 403 genes involved in lung development were tested in 7,749 adults from three studies (NFBC1966, ECRHS, EGEA). The most significant SNP for the top 25 genes was followed-up in 46,103 adults (CHARGE and SpiroMeta consortia) and 5,062 children (ALSPAC). Associations were considered replicated if the replication p-value survived Bonferroni correction (p<0.002; 0.05/25), with a nominal p-value considered as suggestive evidence. For SNPs with evidence of replication, effects on the expression levels of nearby genes in lung tissue were tested in 1,111 lung samples (Lung eQTL consortium), with further functional investigation performed using public epigenomic profiling data (ENCODE). Results NCOR2-rs12708369 showed strong replication in children (p = 0.0002), with replication unavailable in adults due to low imputation quality. This intronic variant is in a strong transcriptional enhancer element in lung fibroblasts, but its eQTL effects could not be tested due to low imputation quality in the eQTL dataset. SERPINE2-rs6754561 replicated at nominal level in both adults (p = 0.036) and children (p = 0.045), while WNT16-rs2707469 replicated at nominal level only in adults (p = 0.026). The eQTL analyses showed association of WNT16-rs2707469 with expression levels of the nearby gene CPED1.We found no statistically significant eQTL effects for SERPINE2-rs6754561. Conclusions We have identified a new gene, NCOR2, in the retinoic acid signalling pathway pointing to a role of Vitamin A metabolism in the regulation of FVC. Our findings also support SERPINE2, a COPD gene with weak previous evidence of association with FVC, and suggest WNT16 as a further promising candidate.

DOI 10.1371/journal.pone.0147388
Co-authors Christopher Oldmeadow, Rodney Scott, Liz Holliday
2015 Johnson NA, Kypri K, Latter J, McElduff P, Attia J, Saitz R, et al., 'Effect of telephone follow-up on retention and balance in an alcohol intervention trial', Preventive Medicine Reports, 2 746-749 (2015) [C1]

© 2015 The Authors. Objectives: Telephone follow-up is not currently recommended as a strategy to improve retention in randomized trials. The aims of this study were to estimate ... [more]

© 2015 The Authors. Objectives: Telephone follow-up is not currently recommended as a strategy to improve retention in randomized trials. The aims of this study were to estimate the effect of telephone follow-up on retention, identify participant characteristics predictive of questionnaire completion during or after telephone follow-up, and estimate the effect of including participants who provided follow-up data during or after telephone follow-up on balance between randomly allocated groups in a trial estimating the effect of electronic alcohol screening and brief intervention on alcohol consumption in hospital outpatients with hazardous or harmful drinking. Method: Trial participants were followed up 6. months after randomization (June-December 2013) using e-mails containing a hyperlink to a web-based questionnaire when possible and by post otherwise. Telephone follow-up was attempted after two written reminders and participants were invited to complete the questionnaire by telephone when contact was made. Results: Retention before telephone follow-up was 62.1% (520/837) and 82.8% (693/837) afterward: an increase of 20.7% (173/837). Therefore, 55% (95% CI 49%-60%) of the 317 participants who had not responded after two written reminders responded during or after the follow-up telephone call. Age. <. 55. years, a higher AUDIT-C score and provision of a mobile/cell phone number were predictive of questionnaire completion during or after telephone follow-up. Balance between randomly allocated groups was present before and after inclusion of participants who completed the questionnaire during or after telephone follow-up. Conclusion: Telephone follow-up improved retention in this randomized trial without affecting balance between the randomly allocated groups.

DOI 10.1016/j.pmedr.2015.08.016
Co-authors Joanna Latter, Luke Wolfenden, Natalie Johnson, Adrian Dunlop, Kypros Kypri
2015 Kelly PJ, Baker AL, Deane FP, Callister R, Collins CE, Oldmeadow C, et al., 'Study protocol: A stepped wedge cluster randomised controlled trial of a healthy lifestyle intervention for people attending residential substance abuse treatment Health behavior, health promotion and society', BMC Public Health, 15 (2015) [C3]

© 2015 Kelly et al.; licensee BioMed Central. Background: Cardiovascular disease and cancer are leading causes of mortality for people with a history of alcohol or other substanc... [more]

© 2015 Kelly et al.; licensee BioMed Central. Background: Cardiovascular disease and cancer are leading causes of mortality for people with a history of alcohol or other substance use disorders. These chronic diseases share the same four primary behavioural risk factors i.e. excessive alcohol use, smoking, low intake of fruit and vegetables and physical inactivity. In addition to addressing problematic alcohol use, there is the potential for substance abuse treatment services to also address these other behaviours. Healthy Recovery is an 8-session group-based intervention that targets these multiple behavioural health risk factors and was developed specifically for people attending substance abuse treatment. This protocol describes a Cancer Institute NSW funded study that assesses the effectiveness of delivering Healthy Recovery for people who are attending residential alcohol and other substance abuse treatment. Methods/Design: The study uses a stepped wedge randomised controlled design, where randomisation occurs at the service level. Participants will be recruited from residential rehabilitation programs provided by The Australian Salvation Army. All participants who (1) currently smoke tobacco and (2) are expected to be in the residential program for the duration of the 5-week intervention will be asked to participate in the study. Those participants residing at the facilities assigned to the treatment condition will complete Healthy Recovery. The intervention is manual guided and will be delivered over a 5-week period, with participants attending 8 group sessions. All participants will continue to complete The Salvation Army residential program, a predominantly 12-step based, modified therapeutic community. Participants in the control condition will complete treatment as usual. Research staff blind to treatment allocation will complete the primary and secondary outcome assessments at baseline and then at weeks 8, 20 and 32 weeks post intervention. Discussion: This study will provide comprehensive data on the effect of delivering a healthy lifestyle intervention (i.e. Healthy Recovery) within a residential substance abuse setting. If shown to be effective, this intervention can be disseminated within other residential substance abuse programs. Trial registration: Australian and New Zealand Clinical Trials Register (ANZCTR): ACTRN12615000165583. Registered 19th February 2015.

DOI 10.1186/s12889-015-1729-y
Co-authors Amanda Baker, Robin Callister, Christopher Oldmeadow, Clare Collins
2015 Roselli S, Pundavela J, Demont Y, Faulkner S, Keene S, Attia J, et al., 'Sortilin is associated with breast cancer aggressiveness and contributes to tumor cell adhesion and invasion', Oncotarget, 6 10473-10486 (2015) [C1]

The neuronal membrane protein sortilin has been reported in a few cancer cell lines, but its expression and impact in human tumors is unclear. In this study, sortilin was analyzed... [more]

The neuronal membrane protein sortilin has been reported in a few cancer cell lines, but its expression and impact in human tumors is unclear. In this study, sortilin was analyzed by immunohistochemistry in a series of 318 clinically annotated breast cancers and 53 normal breast tissues. Sortilin was detected in epithelial cells, with increased levels in cancers, as compared to normal tissues (p = 0.0088). It was found in 79% of invasive ductal carcinomas and 54% of invasive lobular carcinomas (p < 0.0001). There was an association between sortilin expression and lymph node involvement (p = 0.0093), suggesting a relationship with metastatic potential. In cell culture, sortilin levels were higher in cancer cell lines compared to non-tumorigenic breast epithelial cells and siRNA knockdown of sortilin inhibited cancer cell adhesion, while proliferation and apoptosis were not affected. Breast cancer cell migration and invasion were also inhibited by sortilin knockdown, with a decrease in focal adhesion kinase and SRC phosphorylation. In conclusion, sortilin participates in breast tumor aggressiveness and may constitute a new therapeutic target against tumor cell invasion.

Citations Scopus - 1
Co-authors Xu Zhang, Marjorie Walker, Chenchen Jiang, Hubert Hondermarck
2015 Cheng TH, Thompson D, Painter J, O'Mara T, Gorman M, Martin L, et al., 'Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1.', Sci Rep, 5 17369 (2015) [C1]
DOI 10.1038/srep17369
Co-authors Mark Mcevoy, Rodney Scott, Liz Holliday
2015 Bidarian-Moniri A, Nilsson M, Rasmusson L, Attia J, Ejnell H, 'The effect of the prone sleeping position on obstructive sleep apnoea', ACTA OTO-LARYNGOLOGICA, 135 79-84 (2015) [C1]
DOI 10.3109/00016489.2014.962183
Citations Scopus - 1
2015 Squance ML, Reeves G, Attia J, Bridgman H, Guest M, 'Self-reported Lupus flare: Association with everyday home and personal product exposure', Toxicology Reports, 2 880-888 (2015) [C1]

© 2015 Published by Elsevier Ireland Ltd. Background: The number of chemicals in household products has driven concern about potential adverse health through their use. Most rese... [more]

© 2015 Published by Elsevier Ireland Ltd. Background: The number of chemicals in household products has driven concern about potential adverse health through their use. Most research concentrates on product chemicals with reproductive and carcinogenic consequences, however some evidence exists that immune effects can lead to exacerbation of autoimmune illnesses such as lupus (SLE). Objectives: This paper examines household and personal product exposure patterns in a pilot case/control study of female Australians. We also examined associations between common product exposure and SLE symptom exacerbation over a year period. Methods: We enrolled 41 control and 80 SLE participants aged 18-80 years. Qualitative techniques of structured interview and thematic analysis retrospectively explored patterns of product use, and flare history data of SLE participants. Negative binomial regression models explored associations between self-reported flare (SRF) days and exposure to 34 common home product groups. Results: Mean product counts did not differ between participant groups (mean 33.1: SD 11.8), or flare groups (flare mean 32.6:SD 12, no-flare 31.8:SD 6.6). Products used for personal hygiene and general house cleaning were most frequently used.Significant association with increased SRF day relative risk (IRR) was seen for bath oil use (IRR 1.008, CI 1.00-1.02). Paradoxical "protective" effects, (reduced SRF days) were found for cleansing beauty (IRR 0.999, CI 0.998-0.999), make-up (IRR 0.998, CI 0.997-0.999); adhesives (IRR 0.994, CI 0.991-0.997) and paint (IRR 0.99, CI 0.986-0.995). Conclusions: Everyday product exposures can impact on symptom exacerbation in SLE. Some offering protection and others increased health risk. Identifying environmental associations offer the possibility of life-style interventions to reduce illness impact.

DOI 10.1016/j.toxrep.2015.05.010
2015 Rannikmäe K, Davies G, Thomson PA, Bevan S, Devan WJ, Falcone GJ, et al., 'Common variation in COL4A1/COL4A2 is associated with sporadic cerebral small vessel disease', Neurology, 84 918-926 (2015) [C1]

© 2015 American Academy of Neurology. Objectives: We hypothesized that common variants in the collagen genes COL4A1/COL4A2 are associated with sporadic forms of cerebral small ve... [more]

© 2015 American Academy of Neurology. Objectives: We hypothesized that common variants in the collagen genes COL4A1/COL4A2 are associated with sporadic forms of cerebral small vessel disease. Methods: We conducted meta-analyses of existing genotype data among individuals of European ancestry to determine associations of 1,070 common single nucleotide polymorphisms (SNPs) in the COL4A1/COL4A2 genomic region with the following: intracerebral hemorrhage and its subtypes (deep, lobar) (1,545 cases, 1,485 controls); ischemic stroke and its subtypes (cardioembolic, large vessel disease, lacunar) (12,389 cases, 62,004 controls); and white matter hyperintensities (2,733 individuals with ischemic stroke and 9,361 from population-based cohorts with brain MRI data). We calculated a statistical significance threshold that accounted for multiple testing and linkage disequilibrium between SNPs (p < 0.000084). Results: Three intronic SNPs in COL4A2 were significantly associated with deep intracerebral hemorrhage (lead SNP odds ratio [OR] 1.29, 95% confidence interval [CI] 1.14-1.46, p = 0.00003; r2 > 0.9 between SNPs). Although SNPs associated with deep intracerebral hemorrhage did not reach our significance threshold for association with lacunar ischemic stroke (lead SNP OR 1.10, 95% CI 1.03-1.18, p = 0.0073), and with white matter hyperintensity volume in symptomatic ischemic stroke patients (lead SNP OR 1.07, 95% CI 1.01-1.13, p = 0.016), the direction of association was the same. There was no convincing evidence of association with white matter hyperintensities in population-based studies or with non-small vessel disease cerebrovascular phenotypes. Conclusions: Our results indicate an association between common variation in the COL4A2 gene and symptomatic small vessel disease, particularly deep intracerebral hemorrhage. These findings merit replication studies, including in ethnic groups of non-European ancestry.

DOI 10.1212/WNL.0000000000001309
Citations Scopus - 10Web of Science - 1
Co-authors Chris Levi, Liz Holliday
2015 Campbell BCV, Mitchell PJ, Kleinig TJ, Dewey HM, Churilov L, Yassi N, et al., 'Endovascular therapy for ischemic stroke with perfusion-imaging selection', New England Journal of Medicine, 372 1009-1018 (2015) [C1]

Copyright © 2015 Massachusetts Medical Society. Background: Trials of endovascular therapy for ischemic stroke have produced variable results. We conducted this study to test whe... [more]

Copyright © 2015 Massachusetts Medical Society. Background: Trials of endovascular therapy for ischemic stroke have produced variable results. We conducted this study to test whether more advanced imaging selection, recently developed devices, and earlier intervention improve outcomes. Methods: We randomly assigned patients with ischemic stroke who were receiving 0.9 mg of alteplase per kilogram of body weight less than 4.5 hours after the onset of ischemic stroke either to undergo endovascular thrombectomy with the Solitaire FR (Flow Restoration) stent retriever or to continue receiving alteplase alone. All the patients had occlusion of the internal carotid or middle cerebral artery and evidence of salvageable brain tissue and ischemic core of less than 70 ml on computed tomographic (CT) perfusion imaging. The coprimary outcomes were reperfusion at 24 hours and early neurologic improvement (.8-point reduction on the National Institutes of Health Stroke Scale or a score of 0 or 1 at day 3). Secondary outcomes included the functional score on the modified Rankin scale at 90 days. Results: The trial was stopped early because of efficacy after 70 patients had undergone randomization (35 patients in each group). The percentage of ischemic territory that had undergone reperfusion at 24 hours was greater in the endovascular-therapy group than in the alteplase-only group (median, 100% vs. 37%; P<0.001). Endovascular therapy, initiated at a median of 210 minutes after the onset of stroke, increased early neurologic improvement at 3 days (80% vs. 37%, P = 0.002) and improved the functional outcome at 90 days, with more patients achieving functional independence (score of 0 to 2 on the modified Rankin scale, 71% vs. 40%; P = 0.01). There were no significant differences in rates of death or symptomatic intracerebral hemorrhage. Conclusions: In patients with ischemic stroke with a proximal cerebral arterial occlusion and salvageable tissue on CT perfusion imaging, early thrombectomy with the Solitaire FR stent retriever, as compared with alteplase alone, improved reperfusion, early neurologic recovery, and functional outcome. (Funded by the Australian National Health and Medical Research Council and others; EXTEND-IA ClinicalTrials.gov number, NCT01492725, and Australian New Zealand Clinical Trials Registry number, ACTRN12611000969965.)

DOI 10.1056/NEJMoa1414792
Citations Scopus - 416Web of Science - 143
Co-authors Mark Parsons, Chris Levi
2015 Greenop KR, Bailey HD, Miller M, Scott RJ, Attia J, Ashton LJ, et al., 'Breastfeeding and nutrition to 2 years of age and risk of childhood acute lymphoblastic leukemia and brain tumors', Nutrition and Cancer, 67 431-441 (2015) [C1]

© 2015 Taylor & Francis Group, LLC. Acute lymphoblastic leukemia (ALL) and childhood brain tumors (CBT) are 2 of the most common forms of childhood cancer, but little is known of... [more]

© 2015 Taylor & Francis Group, LLC. Acute lymphoblastic leukemia (ALL) and childhood brain tumors (CBT) are 2 of the most common forms of childhood cancer, but little is known of their etiology. In 2 nationwide case-control studies we investigated whether breastfeeding, age of food introduction, or early diet are associated with the risk of these cancers. Cases aged 0-14 years were identified from Australian pediatric oncology units between 2003 and 2007 (ALL) and 2005 and 2010 (CBT) and population-based controls through nationwide random-digit dialing. Mothers completed questionnaires giving details of infant feeding up to the age of 2 yr. Data from 322 ALL cases, 679 ALL controls, 299 CBT cases, and 733 CBT controls were analysed using unconditional logistic regression. Breastfeeding was associated with a reduced risk of ALL [odds ratio (OR) = 0.52, 95% confidence interval (CI): 0.32, 0.84), regardless of duration. Introduction of artificial formula within 14 days of birth was positively associated with ALL (OR = 1.57, 95% CI: 1.03, 2.37), as was exclusive formula feeding to 6 mo (OR = 1.81, 95% CI: 1.07, 3.05). No associations were seen between breastfeeding or formula use and risk of CBT. Our results suggest that breastfeeding and delayed introduction of artificial formula may reduce the risk of ALL but not CBT.

DOI 10.1080/01635581.2015.998839
Citations Scopus - 2Web of Science - 1
Co-authors Rodney Scott
2015 NINDS Stroke Genetics Network (SiGN) and International Stroke Genetics Consortium (ISGC), Attia JR, Holliday E, 'Loci associated with ischaemic stroke and its subtypes (SiGN): A genome-wide association study', Lancet Neurology, 174-184 (2015)
DOI 10.1016/S1474-4422(15)00338-5
Co-authors Liz Holliday, Jane Maguire
2015 Bidarian-Moniri A, Nilsson M, Attia J, Ejnell H, 'Mattress and pillow for prone positioning for treatment of obstructive sleep apnoea', Acta Oto-Laryngologica, 135 271-276 (2015) [C1]

© 2015 Informa Healthcare. Conclusion: The new mattress and pillow for prone positioning (MPP) is efficient in reducing the apnoea-hypopnoea index (AHI) and oxygen desaturation i... [more]

© 2015 Informa Healthcare. Conclusion: The new mattress and pillow for prone positioning (MPP) is efficient in reducing the apnoea-hypopnoea index (AHI) and oxygen desaturation index (ODI) in most patients with obstructive sleep apnoea (OSA), with satisfactory compliance. Objective: The aim of the present study was to evaluate the effect of the prone body and head sleep position on severity of disease in patients with OSA after 4 weeks of adaptation to a mattress and pillow facilitating prone positioning. Methods: Fourteen patients with mild to severe OSA, 11 men and 3 women with a mean AHI of 26 (min, 6; max, 53) and mean ODI of 21 (min, 6; max, 51) were evaluated. Two polysomnographic (PSG) studies were performed. The first PSG study was without any treatment and the second was after 4 weeks of adaptation to the MPP for prone positioning of the body and the head. Results: Mean AHI and ODI decreased from 26 and 21 to 8 and 7, respectively (p < 0.001) with treatment. The mean time spent in the supine position was reduced from 128 to 10 min (p = 0.02) and the prone time increased from 42 to 174 min (p = 0.02) with the MPP. The mean total sleep time was 390 min during the first PSG study night without treatment and 370 min during the second night with the MPP (p = 0.7). Ten patients (71%) reduced their AHI by at least 50% and reached a value < 10 during treatment. All patients managed to sleep on the MPP for > 4 h per night during the 4-week study.

DOI 10.3109/00016489.2014.968674
2015 Chan JPL, Thalamuthu A, Oldmeadow C, Armstrong NJ, Holliday EG, McEvoy M, et al., 'Genetics of hand grip strength in mid to late life', Age, 37 1-10 (2015) [C1]

© 2015, American Aging Association. Hand grip strength (GS) is a predictor of mortality in older adults and is moderately to highly heritable, but no genetic variants have been c... [more]

© 2015, American Aging Association. Hand grip strength (GS) is a predictor of mortality in older adults and is moderately to highly heritable, but no genetic variants have been consistently identified. We aimed to identify single nucleotide polymorphisms (SNPs) associated with GS in middle-aged to older adults using a genome-wide association study (GWAS). GS was measured using handheld dynamometry in community-dwelling men and women aged 55¿85 from the Hunter Community Study (HCS, N = 2088) and the Sydney Memory and Ageing Study (Sydney MAS, N = 541). Genotyping was undertaken using Affymetrix microarrays with imputation to HapMap2. Analyses were performed using linear regression. No genome-wide significant results were observed in HCS nor were any of the top signals replicated in Sydney MAS. Gene-based analyses in HCS identified two significant genes (ZNF295, C2CD2), but these results were not replicated in Sydney MAS. One out of eight SNPs previously associated with GS, rs550942, located near the CNTF gene, was significantly associated with GS (p = 0.005) in the HCS cohort only. Study differences may explain the lack of consistent results between the studies, including the smaller sample size of the Sydney MAS cohort. Our modest sample size also had limited power to identify variants of small effect. Our results suggest that similar to various other complex traits, many genetic variants of small effect size may influence GS. Future GWAS using larger samples and consistent measures may prove more fruitful at identifying genetic contributors for GS in middle-aged to older adults.

DOI 10.1007/s11357-015-9745-5
Co-authors Christopher Oldmeadow, Mark Mcevoy, Roseanne Peel, Rodney Scott, Liz Holliday
2015 Greenop KR, Scott RJ, Attia J, Bower C, de Klerk NH, Norris MD, et al., 'Folate Pathway Gene Polymorphisms and Risk of Childhood Brain Tumors: Results from an Australian Case-Control Study', CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 24 931-937 (2015) [C1]
DOI 10.1158/1055-9965.EPI-14-1248
Co-authors Rodney Scott
2015 Lai JS, Hure AJ, Oldmeadow C, McEvoy M, Byles J, Attia J, 'Prospective study on the association between diet quality and depression in mid-aged women over 9 years', European Journal of Nutrition, (2015)

© 2015 Springer-Verlag Berlin Heidelberg Purpose: To examine the longitudinal association between diet quality and depression using prospective data from the Australian Longitudi... [more]

© 2015 Springer-Verlag Berlin Heidelberg Purpose: To examine the longitudinal association between diet quality and depression using prospective data from the Australian Longitudinal Study on Women¿s Health. Methods: Women born in 1946¿1951 (n = 7877) were followed over 9 years starting from 2001. Dietary intake was assessed using the Dietary Questionnaire for Epidemiological Studies (version 2) in 2001 and a shortened form in 2007 and 2010. Diet quality was summarised using the Australian Recommended Food Score. Depression was measured using the 10-item Centre for Epidemiologic Depression Scale and self-reported physician diagnosis. Pooled logistic regression models including time-varying covariates were used to examine associations between diet quality tertiles and depression. Women were also categorised based on changes in diet quality during 2001¿2007. Analyses were adjusted for potential confounders. Results: The highest tertile of diet quality was associated marginally with lower odds of depression (OR 0.94; 95 % CI 0.83, 1.00; P = 0.049) although no significant linear trend was observed across tertiles (OR 1.00; 95 % CI 0.94, 1.10; P = 0.48). Women who maintained a moderate or high score over 6 years had a 6¿14 % reduced odds of depression compared with women who maintained a low score (moderate vs low score¿OR 0.94; 95 % CI 0.80, 0.99; P = 0.045; high vs low score¿OR 0.86; 95 % CI 0.77, 0.96; P = 0.01). Similar results were observed in analyses excluding women with prior history of depression. Conclusion: Long-term maintenance of good diet quality may be associated with reduced odds of depression. Randomised controlled trials are needed to eliminate the possibility of residual confounding.

DOI 10.1007/s00394-015-1078-8
Citations Scopus - 1
Co-authors Alexis Hure, Julie Byles, Christopher Oldmeadow, Mark Mcevoy
2015 Milne E, Greenop KR, Scott RJ, Haber M, Norris MD, Attia J, et al., 'Folate pathway gene polymorphisms, maternal folic acid use, and risk of childhood acute lymphoblastic leukemia', Cancer Epidemiology Biomarkers and Prevention, 24 48-56 (2015) [C1]

© 2014 American Association for Cancer Research. Background: Several studies suggest that maternal folic acid supplementation before or during pregnancy protects against childhoo... [more]

© 2014 American Association for Cancer Research. Background: Several studies suggest that maternal folic acid supplementation before or during pregnancy protects against childhood acute lymphoblastic leukemia (ALL). We investigated associations between ALL risk and folate pathway gene polymorphisms, and their modification by maternal folic acid supplements, in a population-based case-control study (2003-2007). Methods: All Australian pediatric oncology centers provided cases; controls were recruited by national random digit dialing. Data from 392 cases and 535 controls were included. Seven folate pathway gene polymorphisms (MTHFR 677C>T, MTHFR 1298A>C, MTRR 66A>G, MTR 2756 A>G, MTR 5049 C>A, CBS 844 Ins68, and CBS 2199 T>C) were genotyped in children and their parents. Information on prepregnancy maternal folic acid supplement use was collected. ORs were estimated with unconditional logistic regression adjusted for frequency-matched variables and potential confounders. Case-parent trios were also analyzed. Results: There was some evidence of a reduced risk of ALL among children who had, or whose father had, the MTRR 66GG genotype: ORs 0.60 [95% confidence interval (CI) 0.39-0.91] and 0.64 (95% CI, 0.40-1.03), respectively. The ORs for paternal MTHFR 677CT and TT genotypes were 1.41 (95% CI, 1.02-1.93) and 1.81 (95% CI, 1.06-3.07). ORs varied little by maternal folic acid supplementation. Conclusions: Some folate pathway gene polymorphisms in the child or a parent may influence ALL risk. While biologically plausible, underlying mechanisms for these associations need further elucidation. Impact: Folate pathway polymorphisms may be related to risk of childhood ALL, but larger studies are needed for conclusive results.

DOI 10.1158/1055-9965.EPI-14-0680
Citations Scopus - 2
Co-authors Rodney Scott
2015 Kongtharvonskul J, Anothaisintawee T, McEvoy M, Attia J, Woratanarat P, Thakkinstian A, 'Efficacy and safety of glucosamine, diacerein, and NSAIDs in osteoarthritis knee: A systematic review and network meta-analysis', European Journal of Medical Research, 20 (2015) [C1]

© 2015 Kongtharvonskul et al.; licensee BioMed Central. Background: To conduct a systematic review and network meta-analysis of randomized controlled trials (RCTs) with the aims ... [more]

© 2015 Kongtharvonskul et al.; licensee BioMed Central. Background: To conduct a systematic review and network meta-analysis of randomized controlled trials (RCTs) with the aims of comparing relevant clinical outcomes (that is, visual analog scores (VAS), total and sub-Western Ontario and McMaster Universities Osteoarthritis index (WOMAC) scores, Lequesne algofunctional index, joint space width change, and adverse events) between diacerein, glucosamine, and placebo. Methods: Medline and Scopus databases were searched from inception to 29 August 2014, using PubMed and Scopus search engines and included RCTs or quasi-experimental designs comparing clinical outcomes between treatments. Data were extracted from original studies. A network meta-analysis was performed by applying weight regression for continuous outcomes and a mixed-effect Poisson regression for dichotomous outcomes. Results: Thirty-one of 505 identified studies were eligible. Compared to placebo, glucosamine showed a significant improvement with unstandardized mean differences (UMD) in total WOMAC, pain WOMAC, function WOMAC, and Lequesne score of -2.49 (95% confidence interval (CI) -4.14, -0.83), -0.75 (95% CI: -1.18, -0.32), -4.78 (95% CI: -5.96, -3.59), and -1.03 (95% CI: -1.34, -0.72), respectively. Diacerein clinically improves visual analog scores, function WOMAC, and stiffness WOMAC with UMD values of -2.23 (95% CI: -2.82, -1.64), -6.64 (95% CI: -10.50, -2.78), and -0.68 (95% CI: -1.20, -0.16) when compared to placebo. Conclusions: The network meta-analysis suggests that diacerein and glucosamine are equally efficacious for symptom relief in knee OA, but that the former has more side effects.

DOI 10.1186/s40001-015-0115-7
Citations Scopus - 1
2015 Mansour D, Mansour KG, Kenny BW, Attia J, Meads B, 'Driving with a short arm cast in a simulator', JOURNAL OF ORTHOPAEDIC SURGERY, 23 327-330 (2015) [C1]
2015 Davies G, Armstrong N, Bis JC, Bressler J, Chouraki V, Giddaluru S, et al., 'Genetic contributions to variation in general cognitive function: A meta-analysis of genome-wide association studies in the CHARGE consortium (N=53 949)', Molecular Psychiatry, 20 183-192 (2015) [C1]

© 2015 Macmillan Publishers Limited. General cognitive function is substantially heritable across the human life course from adolescence to old age. We investigated the genetic c... [more]

© 2015 Macmillan Publishers Limited. General cognitive function is substantially heritable across the human life course from adolescence to old age. We investigated the genetic contribution to variation in this important, health- and well-being-related trait in middle-aged and older adults. We conducted a meta-analysis of genome-wide association studies of 31 cohorts (N=53 949) in which the participants had undertaken multiple, diverse cognitive tests. A general cognitive function phenotype was tested for, and created in each cohort by principal component analysis. We report 13 genome-wide significant single-nucleotide polymorphism (SNP) associations in three genomic regions, 6q16.1, 14q12 and 19q13.32 (best SNP and closest gene, respectively: rs10457441, P=3.93 × 10-9, MIR2113; rs17522122, P=2.55 × 10-8, AKAP6; rs10119, P=5.67 × 10-9, APOE/TOMM40). We report one gene-based significant association with the HMGN1 gene located on chromosome 21 (P=1 × 10-6). These genes have previously been associated with neuropsychiatric phenotypes. Meta-analysis results are consistent with a polygenic model of inheritance. To estimate SNP-based heritability, the genome-wide complex trait analysis procedure was applied to two large cohorts, the Atherosclerosis Risk in Communities Study (N=6617) and the Health and Retirement Study (N=5976). The proportion of phenotypic variation accounted for by all genotyped common SNPs was 29% (s.e.=5%) and 28% (s.e.=7%), respectively. Using polygenic prediction analysis, ~1.2% of the variance in general cognitive function was predicted in the Generation Scotland cohort (N=5487; P=1.5 × 10-17). In hypothesis-driven tests, there was significant association between general cognitive function and four genes previously associated with Alzheimer's disease: TOMM40, APOE, ABCG1 and MEF2C.

DOI 10.1038/mp.2014.188
Citations Scopus - 21Web of Science - 5
Co-authors Christopher Oldmeadow, Liz Holliday, Rodney Scott, Peter Schofield
2015 Sharpley C, Hussain R, Wark S, Mcevoy M, Attia J, 'THE INFLUENCE OF SOCIAL SUPPORT ON PSYCHOLOGICAL DISTRESS IN OLDER PERSONS: AN EXAMINATION OF INTERACTION PROCESSES IN AUSTRALIA.', Psychol Rep, 117 883-896 (2015) [C1]
DOI 10.2466/21.10.PR0.117c27z5
Co-authors Mark Mcevoy
2015 Sapkota Y, Attia J, Gordon SD, Henders AK, Holliday EG, Rahmioglu N, et al., 'Genetic burden associated with varying degrees of disease severity in endometriosis', MOLECULAR HUMAN REPRODUCTION, 21 594-602 (2015) [C1]
DOI 10.1093/molehr/gav021
Citations Scopus - 2Web of Science - 1
Co-authors Mark Mcevoy, Liz Holliday, Rodney Scott
2015 Greenop KR, Hinwood AL, Fritschi L, Scott RJ, Attia J, Ashton LJ, et al., 'Vehicle refuelling, use of domestic wood heaters and the risk of childhood brain tumours: Results from an Australian case-control study', Pediatric Blood and Cancer, 62 229-234 (2015) [C1]

© 2014 Wiley Periodicals, Inc. The aetiology of childhood brain tumours (CBT) is largely unknown. Damage to germ cells after parental exposure to airborne carcinogens, such as vo... [more]

© 2014 Wiley Periodicals, Inc. The aetiology of childhood brain tumours (CBT) is largely unknown. Damage to germ cells after parental exposure to airborne carcinogens, such as volatile organic compounds and polycyclic aromatic hydrocarbons is one plausible pathway. This analysis aimed to investigate whether parental refuelling of vehicles or the use of domestic wood heaters in key time periods relating to the child's birth was associated with an increased risk of CBT. Procedure: Cases <15 years of age were recruited through 10 paediatric oncology centres around Australia; controls were recruited through nationwide random-digit dialling, frequency matched to cases on age, sex and State of residence. Exposure to refuelling and wood heaters was ascertained through questionnaires from both parents. Odds ratios (ORs) and confidence intervals (CIs) were estimated using unconditional logistic regression, adjusting for relevant covariates. Results: Data were available for 306 case and 950 control families. Paternal refuelling =4times/month was associated with an increased risk of CBT (OR 1.59, 95% CI: 1.11, 2.29), and a dose-dependent trend was observed (P=0.004). No association was seen for maternal refuelling. Use of closed, but not open, wood heaters before (OR 1.51, 95% CI: 1.05, 2.15) and after (OR 1.44, 95% CI: 1.03, 2.01) the child's birth was associated with increased risk of CBT, but dose-response relationships were weak or absent. Conclusions: Paternal refuelling of vehicles =4times/month and the use of closed wood heaters before the child's birth may increase the risk of CBT. Replication in larger studies is needed.

DOI 10.1002/pbc.25268
Co-authors Rodney Scott
2015 Vejakama P, Ingsathit A, Attia J, Thakkinstian A, 'Epidemiological study of chronic kidney disease progression: A large-scale population-based cohort study', Medicine (United States), 94 (2015) [C1]

Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. The prognostic information about CKD progression, particularly for GFR categories 1 and 2, is still limited. Thi... [more]

Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. The prognostic information about CKD progression, particularly for GFR categories 1 and 2, is still limited. This cohort was therefore conducted to determine the CKD progression using a competing risk approach. We conducted a retrospective cohort study linking community health screening with hospitals and death registry data in a province of Thailand, from 1997 to 2011. A competing risk model was applied by treating death as a competing risk factor to estimate 2-, 5-, and 10-year probability of kidney failure and median time for CKD progression from lower to higher GFR category. There were 17,074 non-diabetic and 15,032 diabetic CKD subjects. Diabetic subjects progressed more rapidly through GFR categories with the median times for CKD progression from GFR categories G1 to G2, G2 to G3a, G3a to G3b, G3b to G4, and G4 to G5 of 4.4, 6.1, 4.9, 6.3, and 9.0 years, respectively. Non-diabetic subjects took longertoprogress with the corresponding median timeof9.4, 14.0, 11.0, 13.8, and >14.3 years. After adjusting for confounders, diabetic subjects were 49% (cause-specific hazard ratio (cHR) = 1.49, 95% CI: 1.37, 1.62) more likely to develop kidney failure than non-diabetic subjects. Albuminuria categories A3 and A2 were, respectively, 3.40 (95% CI: 3.07, 3.76) and 1.71 (95% CI: 1.53, 1.92) higher risk of kidney failure when compared to A1. For each albumin category, death rate increased as albuminuria increased particularly in diabetic subjects, which was approximately 2 times higher in A3 compared to A1. Considering GFR category, it gradually increased from G1 to G4 and sharply increased from G4 to G5 in both non-diabetic and diabetic subjects. This study has quantified CKD progression in an Asian population within ordinary practice. Diabetic subjects progress through GFR and albuminuria categories and reach kidney failure about twice as rapidly as non-diabetic subjects.

DOI 10.1097/MD.0000000000000475
Citations Scopus - 1
2015 Delahunt B, Egevad L, Srigley JR, Steigler A, Murray JD, Atkinson C, et al., 'Validation of International Society of Urological Pathology (ISUP) grading for prostatic adenocarcinoma in thin core biopsies using TROG 03.04 'RADAR' trial clinical data', Pathology, 47 520-525 (2015) [C1]

Copyright © 2015 Royal College of Pathologists of Australasia. All rights reserved. In 2014 a consensus conference convened by the International Society of Urological Pathology (... [more]

Copyright © 2015 Royal College of Pathologists of Australasia. All rights reserved. In 2014 a consensus conference convened by the International Society of Urological Pathology (ISUP) adopted amendments to the criteria for Gleason grading and scoring (GS) for prostatic adenocarcinoma. The meeting defined a modified grading system based on 5 grading categories (grade 1, GS 3+3; grade 2, GS 3+4; grade 3, GS 4+3; grade 4, GS 8; grade 5, GS 9-10). In this study we have evaluated the prognostic significance of ISUP grading in 496 patients enrolled in the TROG 03.04 RADAR Trial. There were 19 grade 1, 118 grade 2, 193 grade 3, 88 grade 4 and 79 grade 5 tumours in the series, with follow-up for a minimum of 6.5 years. On follow-up 76 patients experienced distant progression of disease, 171 prostate specific antigen (PSA) progression and 39 prostate cancer deaths. In contrast to the 2005 modified Gleason system (MGS), the hazards of the distant and PSA progression endpoints, relative to grade 2, were significantly greater for grades 3, 4 and 5 of the 2014 ISUP grading scheme. Comparison of predictive ability utilising Harrell's concordance index, showed 2014 ISUP grading to significantly out-perform 2005 MGS grading for each of the three clinical endpoints.

DOI 10.1097/PAT.0000000000000318
Citations Scopus - 2
Co-authors Allison Steigler, Jim Denham
2015 Denham JW, Steigler A, Joseph D, Lamb DS, Spry NA, Duchesne G, et al., 'Radiation dose escalation or longer androgen suppression for locally advanced prostate cancer? Data from the TROG 03.04 RADAR trial', Radiotherapy and Oncology, 115 301-307 (2015) [C1]
DOI 10.1016/j.radonc.2015.05.016
Citations Scopus - 8
Co-authors Christopher Oldmeadow, Jim Denham, Liz Holliday, Allison Steigler
2015 Hiles SA, Baker AL, de Malmanche T, McEvoy M, Boyle M, Attia J, 'Unhealthy lifestyle may increase later depression via inflammation in older women but not men', Journal of Psychiatric Research, 63 65-74 (2015) [C1]

© 2015 Elsevier Ltd. Depression and inflammatory markers have a reliable cross-sectional association although less is known about the prospective relationship. The current study ... [more]

© 2015 Elsevier Ltd. Depression and inflammatory markers have a reliable cross-sectional association although less is known about the prospective relationship. The current study investigated whether pro-inflammatory markers are prospectively associated with depression, and whether indicators of unhealthy lifestyle, physical health and psychosocial functioning may drive this association. Participants were drawn from the Hunter Community Study, a community-dwelling cohort of individuals aged 55-85 years (N=1410). Participants completed baseline physiological assessment, health-related questionnaires, and blood sampling for the analysis of inflammatory markers, C-reactive protein (CRP) and interleukin (IL)-6. Participants completed the same depressive symptom questionnaire again after 3.5-5.5 years. Depression outcomes at follow-up were analysed dichotomously using established scale cut-off scores and continuously as a "residual score", representing the variation in follow-up depressive symptoms not explained by baseline symptoms and age. Analyses were conducted on males and females separately. At baseline, indicators of unhealthy lifestyle, physical health and psychosocial functioning were associated with depressive symptoms and inflammatory markers. For males, there were no relationships between inflammatory markers and follow-up depression outcomes. In females, IL-6 was significantly associated with depression outcomes in univariate, but not multivariate analyses. However, IL-6 significantly mediated the association between the predictors of waist-to-hip ratio, smoking and psychological coping at baseline, and follow-up depression outcomes. The results support the inflammatory hypothesis of depression, although females may be more vulnerable to effects. The findings raise the possibility that unhealthy lifestyle and psychosocial stress may drive inflammation and subsequent depressive symptoms.

DOI 10.1016/j.jpsychires.2015.02.010
Citations Scopus - 2Web of Science - 1
Co-authors Mark Mcevoy, Amanda Baker
2015 Nead KT, Sharp SJ, Thompson DJ, Painter JN, Savage DB, Semple RK, et al., 'Evidence of a Causal Association Between Insulinemia and Endometrial Cancer: A Mendelian Randomization Analysis.', Journal of the National Cancer Institute, 107 (2015) [C1]
Citations Scopus - 5Web of Science - 1
Co-authors Rodney Scott, Mark Mcevoy, Liz Holliday
2015 Ren S, Newby D, Li SC, Walkom E, Miller P, Hure A, Attia J, 'Effect of the adult pneumococcal polysaccharide vaccine on cardiovascular disease: a systematic review and meta-analysis.', Open Heart, 2 1-9 (2015) [C1]
DOI 10.1136/openhrt-2015-000247
Co-authors Emily Walkom, Alexis Hure, Shuchuen Li, David Newby
2015 Kypri K, Wilson A, Attia J, Sheeran PJ, McCambridge J, 'Effects of study design and allocation on self-reported alcohol consumption: Randomized trial', Trials, 16 (2015) [C1]

© Kypri et al. Background: What participants think about the nature of a study might affect their behaviour and bias findings. We tested two hypotheses: (1) participants told the... [more]

© Kypri et al. Background: What participants think about the nature of a study might affect their behaviour and bias findings. We tested two hypotheses: (1) participants told they were in an intervention trial would report lower alcohol consumption at follow-up than those told they were in a cohort study; (2) participants told they were in the intervention group in a trial would have lower alcohol consumption at follow-up than those told they were in the control group. Methods: Students from four universities (N = 72,903) were invited to participate in a 'research project on student drinking'. Of 10,415 respondents, 6,788 were moderate to heavy drinkers and were randomized. Group A ('cohort') were informed their drinking would be assessed at baseline and again in one month. Group B ('control') were told the study was an intervention trial and they were in the control group. Group C ('intervention') were told the study was an intervention trial and they were to receive the intervention. All were assessed and directed to read identical online alcohol education material. Whether and how long they accessed the material were recorded. One month later, alcohol intake was reassessed. Results: In relation to hypothesis 1, there were no differences between the groups on the prespecified outcome measures. In relation to hypothesis 2, there were no differences though all point estimates were in the hypothesized direction (that is, 'intervention' < 'control'). The 'cohort' and 'control' groups accessed the material to a similar extent (59% versus 57%) while the 'intervention' group were more likely to access it (78%) and to read it for longer (median 35 s (25th and 75th percentiles: 6, 97) versus medians of 7 s (0, 28) and 8 s (4, 42) for the 'cohort' and 'control' groups, respectively). Conclusions: Although the context given to the research participants significantly influenced access to the online information and reading time, this did not translate into any effect on drinking behaviour, for either hypothesis. This might be because of failure in the experimental paradigm or the possibility of weaker effects using the online approach.

DOI 10.1186/s13063-015-0642-0
Co-authors Amanda Wilson, Kypros Kypri
2015 Dunn A, Marsden DL, Nugent E, Van Vliet P, Spratt NJ, Attia J, Callister R, 'Protocol variations and six-minute walk test performance in stroke survivors: A systematic review with meta-analysis', Stroke Research and Treatment, 2015 1-28 (2015) [C1]
DOI 10.1155/2015/484813
Citations Scopus - 1
Co-authors Neil Spratt, Robin Callister, Paulette Vanvliet
2015 Briggs S, Pearce R, Dilworth S, Higgins I, Hullick C, Attia J, 'Clinical pharmacist review: A randomised controlled trial', EMA - Emergency Medicine Australasia, 27 419-426 (2015) [C1]

© 2015 Australasian College for Emergency Medicine and Australasian Society for Emergency Medicine. Objectives: To determine if medication review by a clinical pharmacist of olde... [more]

© 2015 Australasian College for Emergency Medicine and Australasian Society for Emergency Medicine. Objectives: To determine if medication review by a clinical pharmacist of older patients in the ED impacted on admission to hospital and other outcomes. Methods: A stratified, randomised controlled study comparing the intervention to current practice. A tertiary referral ED in New South Wales, Australia. Older people (>70 years) living at home who initially reported taking greater than five medications. Medication review by an experienced hospital pharmacist within the ED. Rate of admission, rate of readmission, length of stay and admission to an aged care facility at 4 months post presentation, and rate of general practitioner acceptance of pharmacist recommendations. Results: The odds of admission decreased for those receiving the intervention (odds ratio [OR] = 0.68, 95% confidence interval [CI]: 0.53, 0.87; P = 0.002). There was no evidence that the intervention affected hospital length of stay for admitted patients (0.09 days change, 95% CI -0.08, 0.25; P = 0.31), the rate of re-presentation (0.08% change, 95% CI -0.12, 0.28; P = 0.44) or admission to an aged care facility. The odds of admission to an aged care facility increased with the Identification of Seniors at Risk score. General practitioners adopted 49% of pharmacists' recommendations. Conclusions: The presence of an experienced pharmacist in the ED reduced hospital admissions. Further study is required to determine longer term impacts of General Medical Practitioner acceptance of pharmacists' recommendations.

DOI 10.1111/1742-6723.12451
Citations Scopus - 1
Co-authors Isabel Higgins
2015 Abdullah N, Abdul Murad NA, Attia J, Oldmeadow C, Mohd Haniff EA, Syafruddin SE, et al., 'Characterizing the genetic risk for Type 2 diabetes in a Malaysian multi-ethnic cohort.', Diabet Med, 32 1377-1384 (2015) [C1]
DOI 10.1111/dme.12735
Co-authors Rodney Scott, Liz Holliday, Christopher Oldmeadow
2015 van Dyk M, Mangoni AA, McEvoy M, Attia JR, Sorich MJ, Rowland A, 'Targeted arginine metabolomics: A rapid, simple UPLC-QToF-MSE based approach for assessing the involvement of arginine metabolism in human disease', Clinica Chimica Acta, 447 59-65 (2015) [C1]

© 2015 Elsevier B.V.. Background: Nitric oxide synthase (NOS) mediated conversion of arginine (ARG) to citrulline (CIT) is a key pathway for nitric oxide synthesis. ARG is also m... [more]

© 2015 Elsevier B.V.. Background: Nitric oxide synthase (NOS) mediated conversion of arginine (ARG) to citrulline (CIT) is a key pathway for nitric oxide synthesis. ARG is also metabolised by alternate pathways to ornithine (ORN), homoarginine (HMA), NG-monomethyl-L-arginine (MMA), NG,. NG-dimethyl-L-arginine (ADMA) and NG,. NG'-dimethyl-L-arginine (SDMA), all of which have the capacity to alter NOS activity. Simultaneous assessment of these analytes, when assessing the impact of arginine metabolism in human disease states, is desirable. Methods: Analytes (ARG, ADMA, SDMA, MMA, HMA, CIT and ORN) were isolated from human plasma by solvent extraction, evaporated and reconstituted. Ultra-performance liquid chromatography (UPLC) was performed on a 150mm×2.1mm T3 HSS column using a gradient mobile phase comprising ammonium formate (10mM, pH3.8) in methanol (1% to 63%). Analytes were detected by time-of-flight mass spectrometry (Q-ToF-MS) in positive ion mode with electrospray ionisation (ESI+). Data were collected using MSE. Results: Solvent extraction provided high recovery (>95%). UPLC-QToF-MSE facilitated the separation and quantification of the 7 analytes in an analysis time of 6min. The approach has high sensitivity; LOQ range from 0.005µM (NMMA) to 0.25µM (ARG and ORN), and good precision; intra- and inter-day %RSD are <6% for all analytes. Conclusions: This approach provides the capacity to quantify 7 key compounds involved in ARG metabolism in a small sample volume, with a short total analysis time. These characteristics make this approach ideal for undertaking a comprehensive characterisation of this pathway in large data sets (e.g. population studies).

DOI 10.1016/j.cca.2015.05.014
Citations Scopus - 1
Co-authors Mark Mcevoy
2015 Vashum KP, McEvoy MA, Hancock SJ, Islam MR, Peel R, Attia JR, Milton AH, 'Prevalence of and associations with excessive daytime sleepiness in an Australian older population', Asia-Pacific Journal of Public Health, 27 NP2275-NP2284 (2015) [C1]

© 2013 APJPH. The aim of this research is to estimate the prevalence of excessive daytime sleepiness in an older population and associations with sociodemographic, health, and li... [more]

© 2013 APJPH. The aim of this research is to estimate the prevalence of excessive daytime sleepiness in an older population and associations with sociodemographic, health, and lifestyle factors using a cross-sectional, population-based study. Participants were men (1560) and women (1759), aged 55 to 85 years, enrolled in the Hunter Community Study, a longitudinal study of aging. Measurements were self-reported questionnaires, biochemical measures, and clinical measures. Of the 3319 participants, 3053 participants completed the Epworth Sleepiness Scale questionnaire. The prevalence of excessive daytime sleepiness was 15.3% overall and this was higher in males. In adjusted multivariate analysis, gender, working full time, body mass index, high-density and low-density lipoprotein cholesterol, Center for Epidemiologic Studies-Depression scale score, and Kessler psychological distress score were associated with excessive daytime sleepiness. Given the high prevalence of excessive daytime sleepiness observed in this study, further investigation and/or interventions to reduce adverse health outcomes, especially in males is warranted.

DOI 10.1177/1010539513497783
Citations Scopus - 2
Co-authors Roseanne Peel, Milton Hasnat, Mark Mcevoy
2015 Hiles SA, Baker AL, de Malmanche T, McEvoy M, Boyle M, Attia J, 'The role of inflammatory markers in explaining the association between depression and cardiovascular hospitalisations', Journal of Behavioral Medicine, 38 609-619 (2015) [C1]

© 2015, Springer Science+Business Media New York. This study investigated whether inflammation may explain the relationship between depression and incident cardiovascular hospita... [more]

© 2015, Springer Science+Business Media New York. This study investigated whether inflammation may explain the relationship between depression and incident cardiovascular hospitalisations. Participants (55¿85¿years) completed baseline depression and physical assessment. Those without self-reported cardiovascular events were followed prospectively for hospital admissions for angina, myocardial infarction and cerebral infarction (median 937¿days). Across 5140 person-years of risk (N¿=¿1692), there were 47 incident cardiovascular hospitalisations (2.8¿%). Controlling for age and gender, interleukin (IL)-6, C-reactive protein (CRP), body mass index (BMI) and waist-to-hip ratio were associated with future cardiovascular events. Mediation analysis showed that CRP accounted for 8.1¿% and IL-6 10.9¿% of the effect of depression on cardiovascular events, and including the indirect effect in the model substantially reduced the direct relationship between depression and cardiovascular hospitalisations. BMI and waist-to-hip ratio accounted for indirect effects of 7.7 and 10.4¿%, respectively. Inflammatory markers partly explain the association between depression and cardiovascular events, although other shared factors also likely contribute.

DOI 10.1007/s10865-015-9637-2
Co-authors Amanda Baker, Mark Mcevoy
2015 Nakayama A, Major G, Holliday E, Attia J, Bogduk N, 'Evidence of effectiveness of a fracture liaison service to reduce the re-fracture rate', Osteoporosis International, 1-7 (2015)

© 2015 The Author(s) Summary: We assessed the ability of a fracture liaison service (FLS) to directly reduce re-fracture risk. Having a FLS is associated with a ~40 % reduction i... [more]

© 2015 The Author(s) Summary: We assessed the ability of a fracture liaison service (FLS) to directly reduce re-fracture risk. Having a FLS is associated with a ~40 % reduction in the 3-year risk of major bone and ~30 % of any bone re-fracture. The number needed to treat to prevent a re-fracture is 20. Introduction: FLS have been promoted as the most effective interventions for secondary fracture prevention, and while there is evidence of increased rate of investigation and treatment at institutions with a FLS, only a few studies have considered fracture outcomes directly. We therefore sought to evaluate the ability of our FLS to reduce re-fracture risk. Methods: Historical cohort study of all patients =50 years presenting over a 6-month period with a minimal trauma fracture (MTF) to the emergency departments of a tertiary hospital with a FLS, and one without a FLS. Baseline characteristics, mortality and MTFs over a 3-year follow-up were recorded. Results: Five hundred fifteen patients at the FLS hospital and 416 patients at the non-FLS hospital were studied. Over 3 years, 63/515 (12 %) patients at the FLS hospital and 70/416 (17 %) at the non-FLS hospital had a MTF. All patients were analysed in an intention-to-treat analysis regardless of whether they were seen in the FLS follow-up clinic. Statistical analysis using Cox proportional hazard models in the presence of a competing risk of death from any cause was used. After adjustment for baseline characteristics, there was a ~30 % reduction in rate of any re-fracture at the FLS hospital (hazard ratio (HR) 0.67, confidence interval (CI) 0.47-0.95, p value 0.025) and a ~40 % reduction in major re-fractures (hip, spine, femur, pelvis or humerus) (HR 0.59, CI 0.39-0.90, p value 0.013). Conclusions: We found a ~30 % reduction in any re-fractures and a ~40 % reduction in major re-fractures at the FLS hospital compared with a similar non-FLS hospital. The number of patients needed to treat to prevent one new fracture over 3 years is 20.

DOI 10.1007/s00198-015-3443-0
Co-authors Liz Holliday, Nik Bogduk
2015 Debette S, Ibrahim Verbaas CA, Bressler J, Schuur M, Smith A, Bis JC, et al., 'Genome-wide studies of verbal declarative memory in nondemented older people: The Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium', Biological Psychiatry, 77 749-763 (2015) [C1]

© 2015 Society of Biological Psychiatry. BACKGROUND: Memory performance in older persons can reflect genetic influences on cognitive function and dementing processes. We aimed to... [more]

© 2015 Society of Biological Psychiatry. BACKGROUND: Memory performance in older persons can reflect genetic influences on cognitive function and dementing processes. We aimed to identify genetic contributions to verbal declarative memory in a community setting. METHODS: We conducted genome-wide association studies for paragraph or word list delayed recall in 19 cohorts from the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium, comprising 29,076 dementia- and stroke-free individuals of European descent, aged =45 years. Replication of suggestive associations (p < 5 × 10-6) was sought in 10,617 participants of European descent, 3811 African-Americans, and 1561 young adults. RESULTS: rs4420638, near APOE, was associated with poorer delayed recall performance in discovery (p = 5.57 × 10-10) and replication cohorts (p = 5.65 × 10-8). This association was stronger for paragraph than word list delayed recall and in the oldest persons. Two associations with specific tests, in subsets of the total sample, reached genome-wide significance in combined analyses of discovery and replication (rs11074779 [HS3ST4], p = 3.11 × 10-8, and rs6813517 [SPOCK3], p = 2.58 × 10-8) near genes involved in immune response. A genetic score combining 58 independent suggestive memory risk variants was associated with increasing Alzheimer disease pathology in 725 autopsy samples. Association of memory risk loci with gene expression in 138 human hippocampus samples showed cis-associations with WDR48 and CLDN5, both related to ubiquitin metabolism. CONCLUSIONS: This largest study to date exploring the genetics of memory function in ~40,000 older individuals revealed genome-wide associations and suggested an involvement of immune and ubiquitin pathways.

DOI 10.1016/j.biopsych.2014.08.027
Citations Scopus - 5Web of Science - 1
Co-authors Rodney Scott, Liz Holliday, Mark Mcevoy, Peter Schofield, Christopher Oldmeadow
2015 Greenop KR, Miller M, Bailey HD, Scott RJ, Attia J, Bower C, et al., 'Paternal dietary folate, B6 and B12 intake, and the risk of childhood brain tumors', Nutrition and Cancer, 67 224-230 (2015) [C1]

© 2015, Taylor & Francis Group, LLC. It is biologically plausible that a paternal preconception diet low in nutrients related to DNA integrity could affect sperm DNA and subseque... [more]

© 2015, Taylor & Francis Group, LLC. It is biologically plausible that a paternal preconception diet low in nutrients related to DNA integrity could affect sperm DNA and subsequently risk of cancer in the offspring. The aim of this analysis was to investigate whether paternal preconception dietary folate, B6, or B12 intake was associated with the risk of childhood brain tumors (CBT) in an Australian case-control study. Cases <15 years of age were recruited from 10 Australian pediatric oncology centers between 2005 and 2010, and controls from random-digit dialing, frequency-matched to cases on age, sex, and state of residence. Paternal dietary information was obtained by food-frequency questionnaires. Nutrient values were energy adjusted and divided into tertiles for analysis by unconditional logistic regression. In fathers with relevant data (237 cases and 629 controls), no association with dietary folate and B6 and risk of CBT was seen; high B12 intake was associated with an increased risk of CBT (odds ratio highest vs. lowest tertile: 1.74, 95% confidence interval: 1.14, 2.66) without an increasing trend. These results do not support the hypothesis that paternal dietary folate intake influences the risk of CBT. The increased OR observed between dietary B12 intake and risk of CBT is without any certain explanation.

DOI 10.1080/01635581.2015.990571
Co-authors Rodney Scott
2015 Handley TE, Ventura AD, Browne JL, Rich J, Attia JR, Reddy P, et al., 'Suicidal ideation reported by adults with Type 1 or Type 2 diabetes: results from Diabetes MILES-Australia.', Diabet Med, (2015)
DOI 10.1111/dme.13022
Co-authors Jane Rich
2015 Pundavela J, Roselli S, Faulkner S, Attia J, Scott RJ, Thorne RF, et al., 'Nerve fibers infiltrate the tumor microenvironment and are associated with nerve growth factor production and lymph node invasion in breast cancer', Molecular Oncology, 9 1626-1635 (2015) [C1]
DOI 10.1016/j.molonc.2015.05.001
Co-authors John Forbes, Hubert Hondermarck, Marjorie Walker, Phillip Jobling, Rick Thorne, Rodney Scott
2015 Smith S, Pockney P, Attia J, 'Corrigendum: A Meta-analysis on the Effect of Sham Feeding Following Colectomy: Should Gum Chewing Be Included in Enhanced Recovery After Surgery Protocols?', Diseases of the colon and rectum, 58 e416 (2015) [O1]
2015 Greenop KR, Miller M, Bailey HD, de Klerk NH, Attia J, Kellie SJ, et al., 'Childhood folate, B6, B12, and food group intake and the risk of childhood brain tumors: results from an Australian case¿control study', Cancer Causes and Control, 26 871-879 (2015) [C1]

© 2015, Springer International Publishing Switzerland. Purpose: The etiology of childhood brain tumors (CBT) is poorly understood, but dietary factors could be involved. In this ... [more]

© 2015, Springer International Publishing Switzerland. Purpose: The etiology of childhood brain tumors (CBT) is poorly understood, but dietary factors could be involved. In this case¿control study of CBT, the possible associations of childhood intake of dietary and supplemental folate, vitamin B6, and vitamin B12 with the risk of CBT were investigated, along with various food groups. Methods: Cases diagnosed between 2005 and 2010 were identified from 10 pediatric oncology centers in Australia and controls by nationwide random-digit dialling. For study children of ages 3¿14¿years, diet in the year before diagnosis (or recruitment) was assessed using food frequency questionnaires. Folate intake was adjusted for bioavailability, and dietary micronutrient intake was energy-adjusted. Micronutrients and food groups were analyzed using logistic regression adjusting for relevant confounders. Principal components analysis was conducted to assess food group intake patterns for analysis. Results: Food and micronutrient data were available for 216 cases and 523 controls. Folate intake was associated with a reduced risk of CBT overall (odds ratio for highest tertile vs. lowest: 0.63, 95¿% confidence interval 0.41, 0.97) and particularly low-grade gliomas (odds ratio for highest tertile vs. lowest: 0.52, 95¿% confidence interval 0.29, 0.92). Vitamin B6 and B12 intake was not associated with CBT risk, nor was processed meat. Conclusions: High folate intake during childhood may reduce the risk of CBT. This potentially important finding needs to be corroborated in other studies. If replicated, these results could have important implications for public health recommendations regarding diet during childhood.

DOI 10.1007/s10552-015-0562-z
2015 Sansanayudh N, Numthavaj P, Muntham D, Yamwong S, McEvoy M, Attia J, et al., 'Prognostic effect of mean platelet volume in patients with coronary artery disease: A systematic review and meta-analysis', Thrombosis and Haemostasis, 114 1299-1309 (2015) [C1]
DOI 10.1160/TH15-04-0280
Co-authors Mark Mcevoy
2015 Moir-Meyer GL, Pearson JF, Lose F, The ANECSG, Scott RJ, McEvoy M, et al., 'Rare germline copy number deletions of likely functional importance are implicated in endometrial cancer predisposition', Human Genetics, 134 269-278 (2015) [C1]

© 2014, Springer-Verlag Berlin Heidelberg. Endometrial cancer is the most common invasive gynaecological cancer in women, and relatively little is known about inherited risk fact... [more]

© 2014, Springer-Verlag Berlin Heidelberg. Endometrial cancer is the most common invasive gynaecological cancer in women, and relatively little is known about inherited risk factors for this disease. This is the first genome-wide study to explore the role of common and rare germline copy number variants (CNVs) in predisposition to endometrial cancer. CNVs were called from germline DNA of 1,209 endometrioid endometrial cancer cases and 528 cancer-unaffected female controls. Overall CNV load of deletions or DNA gains did not differ significantly between cases and controls (P¿>¿0.05), but cases presented with an excess of rare germline deletions overlapping likely functional genomic regions including genes (P¿=¿8¿×¿10-10), CpG islands (P¿=¿1¿×¿10-7) and sno/miRNAs regions (P¿=¿3¿×¿10-9). On average, at least one additional gene and two additional CpG islands were disrupted by rare deletions in cases compared to controls. The most pronounced difference was that over 30 sno/miRNAs were disrupted by rare deletions in cases for every single disruption event in controls. A total of 13 DNA repair genes were disrupted by rare deletions in 19/1,209 cases (1.6¿%) compared to one gene in 1/528 controls (0.2¿%; P¿=¿0.007), and this increased DNA repair gene loss in cases persisted after excluding five individuals carrying CNVs disrupting mismatch repair genes MLH1, MSH2 and MSH6 (P¿=¿0.03). There were 34 miRNA regions deleted in at least one case but not in controls, the most frequent of which encompassed hsa-mir-661 and hsa-mir-203. Our study implicates rare germline deletions of functional and regulatory regions as possible mechanisms conferring endometrial cancer risk, and has identified specific regulatory elements as candidates for further investigation.

DOI 10.1007/s00439-014-1507-4
Citations Scopus - 1
Co-authors Rodney Scott, Mark Mcevoy, Liz Holliday
2015 Painter JN, O'Mara TA, Batra J, Cheng T, Lose FA, Dennis J, et al., 'Fine-mapping of the HNF1B multicancer locus identifies candidate variants that mediate endometrial cancer risk', HUMAN MOLECULAR GENETICS, 24 1478-1492 (2015) [C1]
DOI 10.1093/hmg/ddu552
Citations Scopus - 5Web of Science - 1
Co-authors Mark Mcevoy, Liz Holliday, Rodney Scott
2015 Kelly AG, Attia J, 'Balancing access and quality in comprehensive stroke care', Neurology, 84 1188-1189 (2015) [C3]
DOI 10.1212/WNL.0000000000001405
2015 Hancock DB, Levy JL, Gaddis NC, Glasheen C, Saccone NL, Page GP, et al., 'Cis-Expression Quantitative Trait Loci Mapping Reveals Replicable Associations with Heroin Addiction in OPRM1', Biological Psychiatry, 78 474-484 (2015) [C1]
DOI 10.1016/j.biopsych.2015.01.003
Citations Scopus - 3Web of Science - 1
Co-authors Mark Mcevoy, Liz Holliday, Rodney Scott
2015 Holliday EG, Traylor M, Malik R, Bevan S, Falcone G, Hopewell JC, et al., 'Genetic Overlap Between Diagnostic Subtypes of Ischemic Stroke', STROKE, 46 615-+ (2015) [C1]
DOI 10.1161/STROKEAHA.114.007930
Citations Scopus - 6
Co-authors Rodney Scott, Lisa Lincz, Chris Levi, Liz Holliday, Jane Maguire, Christopher Oldmeadow
2015 Sapkota Y, Low SK, Attia J, Gordon SD, Henders AK, Holliday EG, et al., 'Association between endometriosis and the interleukin 1A (IL1A) locus.', Human Reproduction, 30 239-248 (2015) [C1]
DOI 10.1093/humrep/deu267
Citations Scopus - 6Web of Science - 4
Co-authors Rodney Scott, Liz Holliday, Mark Mcevoy
2015 Iseme RA, McEvoy M, Kelly B, Agnew L, Attia J, Walker FR, et al., 'Autoantibodies are not predictive markers for the development of depressive symptoms in a population-based cohort of older adults', European Psychiatry, 30 694-700 (2015) [C1]
DOI 10.1016/j.eurpsy.2015.06.006
Co-authors Rohan Walker, Mark Mcevoy, Christopher Oldmeadow, Brian Kelly
2015 O'Mara TA, Glubb DM, Painter JN, Cheng T, Dennis J, Australian National Endometrial Cancer Study Group (ANECS), et al., 'Comprehensive genetic assessment of the ESR1 locus identifies a risk region for endometrial cancer.', Endocr Relat Cancer, 22 851-861 (2015) [C1]
DOI 10.1530/ERC-15-0319
Citations Scopus - 1
Co-authors Mark Mcevoy, Rodney Scott, Liz Holliday
2015 Chiong FJ, Loewenthal M, Boyle M, Attia J, 'Serum sickness-like reaction after influenza vaccination.', BMJ Case Rep, 2015 (2015) [C3]
DOI 10.1136/bcr-2015-211917
2015 Thomas LC, Rivett DA, Attia JR, Levi C, 'Risk factors and clinical presentation of cervical arterial dissection: Preliminary results of a prospective case-control study', Journal of Orthopaedic and Sports Physical Therapy, 45 503-511 (2015) [C1]

Copyright ©2015 Journal of Orthopaedic & Sports Physical Therapy®. All rights reserved. STUDY DESIGN: Cross-sectional case-control study. OBJECTIVES: To identify risk factors an... [more]

Copyright ©2015 Journal of Orthopaedic & Sports Physical Therapy®. All rights reserved. STUDY DESIGN: Cross-sectional case-control study. OBJECTIVES: To identify risk factors and clinical presentation of individuals with cervical arterial dissection. BACKGROUND: Cervical arterial dissection is a common cause of stroke in young people and has in rare cases been associated with cervical manipulative therapy. The mechanism is considered to involve pre-existing arterial susceptibility and a precipitating event, such as minor trauma. Identification of individuals at risk or early recognition of a dissection in progress could help expedite medical intervention and avoid inappropriate treatment. METHODS: Participants were individuals 55 years of age or younger from the Hunter region of New South Wales, Australia with radiologically confirmed vertebral or internal carotid artery dissection and an age- and sex-matched comparison group. Participants were interviewed about risk factors, preceding events, and clinical features of their stroke. Physical examination of joint mobility and soft tissue compliance was undertaken. RESULTS: Twenty-four participants with cervical arterial dissection and 21 matched comparisons with ischemic stroke but not dissection were included in the study. Seventeen (71%) of the 24 participants with dissection reported a recent history of minor mechanical neck trauma or strain, with 4 of these 17 reporting recent neck manipulative therapy treatment. Cardiovascular risk factors were uncommon, with the exception of diagnosed migraine. Among the participants with dissection, 67% reported transient ischemic features in the month prior to their admission for dissection. CONCLUSION: Recent minor mechanical trauma or strain to the head or neck appears to be associated with cervical arterial dissection. General cardiovascular risk factors, with the exception of migraine, were not important risk factors for dissection in this cohort. Preceding transient neurological symptoms appear to occur commonly and may assist in the identification of this serious pathology.

DOI 10.2519/jospt.2015.5877
Citations Scopus - 1
Co-authors Chris Levi, Lucy Thomas, Darren Rivett
2015 Kodur S, Ahmad W, Heittarachi M, Reeves G, Attia J, Barker D, Collins N, 'Influence of age on outcome in patients with pulmonary arterial hypertension', Heart Lung and Circulation, 24 719-723 (2015) [C1]

© 2015 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). Background: The development of ... [more]

© 2015 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). Background: The development of effective orally administered medical therapy for pulmonary arterial hypertension (PAH) has made a significant impact on outcome in patients with PAH. Identification of patient groups likely to derive optimal benefit is important, given cost and potential side effects; the clinical effectiveness of these therapies in older patients with PAH is unclear as the presence of co-morbidity may limit benefits of therapy. Aims: We evaluated the epidemiology of PAH in a contemporary cohort to assess the influence of age on long-term outcome using PAH-specific therapies. Results: A total of 119 patients (88% female; mean age 65±12 years) were reviewed, comprising 52% with underlying connective tissue disease. Bosentan was the PAH specific agent most frequently used. The baseline 6MWT distance in the entire cohort was 304m with age associated with a significant decline in 6MWT. Conclusions: In a large cohort of patients treated with PAH-specific therapies, patients less than 55 years of age showed improvement in 6MWT with older patients demonstrating stabilisation or decline.

DOI 10.1016/j.hlc.2015.01.012
2015 Inder KJ, Hussain R, Allen J, Brew B, Lewin TJ, Attia J, Kelly BJ, 'Factors associated with personal hopefulness in older rural and urban residents of New South Wales', Advances in Mental Health, 13 43-57 (2015) [C1]

© 2015, Taylor & Francis. Background: As research focuses on the concept of resilience, evidence suggests that greater levels of personal hope may have a mitigating effect on the... [more]

© 2015, Taylor & Francis. Background: As research focuses on the concept of resilience, evidence suggests that greater levels of personal hope may have a mitigating effect on the mental health impact of adversity. In view of the adversity affecting rural communities, a better understanding of factors influencing personal hope may help identify foci for mental health promotion and mental illness prevention research and interventions. Aim: To explore the relationship between demographic, socioeconomic and mental health factors and personal hopefulness, including the influence of locality and remoteness. Method: Using data from two community-based longitudinal cohorts from New SouthWales ¿ one urban and one rural ¿ we analysed cross-sectional relationships between a range of factors and personal hopefulness using logistic regression techniques, as part of a common follow-up. Personal hopefulness was measured using a 12-item scale and scores were categorised as low (<2.5), medium (2.5¿3.4) and high (=3.5). Results: Of 2774 participants (53% female, mean age 69.1 years [SD 7.3, range 58¿91 years], 36% living outside metropolitan areas) 32% had low, 51% had medium and 17% had high personal hopefulness scores. Several factors displayed univariate associations with personal hopefulness. In the multivariate model, five factors were independently associated with lower personal hopefulness: being older, having lower perceived prosperity, less frequent socialisation, experiencing high psychological distress or psychological impairment. Hopefulness was not associated with geographical location. Conclusion: The impact of current psychological distress and aspects of adversity on personal hopefulness over time should be further investigated in longitudinal research. Personal hopefulness did not differ across geographical location.

DOI 10.1080/18374905.2015.1039186
Citations Scopus - 1
Co-authors Brian Kelly, Terry Lewin, Kerry Inder
2014 Vashum KP, McEvoy M, Milton AH, McElduff P, Hure A, Byles J, Attia J, 'Dietary zinc is associated with a lower incidence of depression: findings from two Australian cohorts.', J Affect Disord, 166 249-257 (2014) [C1]
DOI 10.1016/j.jad.2014.05.016
Citations Scopus - 14Web of Science - 9
Co-authors Milton Hasnat, Alexis Hure, Julie Byles, Mark Mcevoy
2014 Oldmeadow C, Mossman D, Evans TJ, Holliday EG, Tooney PA, Cairns MJ, et al., 'Combined analysis of exon splicing and genome wide polymorphism data predict schizophrenia risk loci.', J Psychiatr Res, 52 44-49 (2014) [C1]
DOI 10.1016/j.jpsychires.2014.01.011
Citations Scopus - 4Web of Science - 1
Co-authors Rodney Scott, Christopher Oldmeadow, Liz Holliday, Murray Cairns, Paul Tooney
2014 Paul CL, Levi CR, D'Este CA, Parsons MW, Bladin CF, Lindley RI, et al., 'Thrombolysis ImPlementation in Stroke (TIPS): Evaluating the effectiveness of a strategy to increase the adoption of best evidence practice - protocol for a cluster randomised controlled trial in acute stroke care', Implementation Science, 9 (2014) [C3]

Background: Stroke is a leading cause of death and disability internationally. One of the three effective interventions in the acute phase of stroke care is thrombolytic therapy w... [more]

Background: Stroke is a leading cause of death and disability internationally. One of the three effective interventions in the acute phase of stroke care is thrombolytic therapy with tissue plasminogen activator (tPA), if given within 4.5 hours of onset to appropriate cases of ischaemic stroke.Objectives: To test the effectiveness of a multi-component multidisciplinary collaborative approach compared to usual care as a strategy for increasing thrombolysis rates for all stroke patients at intervention hospitals, while maintaining accepted benchmarks for low rates of intracranial haemorrhage and high rates of functional outcomes for both groups at three months.Methods and design: A cluster randomised controlled trial of 20 hospitals across 3 Australian states with 2 groups: multi- component multidisciplinary collaborative intervention as the experimental group and usual care as the control group. The intervention is based on behavioural theory and analysis of the steps, roles and barriers relating to rapid assessment for thrombolysis eligibility; it involves a comprehensive range of strategies addressing individual-level and system-level change at each site. The primary outcome is the difference in tPA rates between the two groups post-intervention. The secondary outcome is the proportion of tPA treated patients in both groups with good functional outcomes (modified Rankin Score (mRS <2) and the proportion with intracranial haemorrhage (mRS =2), compared to international benchmarks.Discussion: TIPS will trial a comprehensive, multi-component and multidisciplinary collaborative approach to improving thrombolysis rates at multiple sites. The trial has the potential to identify methods for optimal care which can be implemented for stroke patients during the acute phase. Study findings will include barriers and solutions to effective thrombolysis implementation and trial outcomes will be published whether significant or not.Trial registration: Australian New Zealand Clinical Trials Registry: ACTRN12613000939796. © 2014 Paul et al.; licensee BioMed Central Ltd.

DOI 10.1186/1748-5908-9-38
Citations Scopus - 2Web of Science - 1
Co-authors Frans Henskens, Catherine Deste, Mark Parsons, Chris Levi, Chris Paul, Rob Sanson-Fisher
2014 Squance ML, Guest M, Reeves G, Attia J, Bridgman H, 'Exploring lifetime occupational exposure and SLE flare: a patient-focussed pilot study.', Lupus Science & Medicine, 1 1-9 (2014) [C1]
DOI 10.1136/lupus-2014-000023
Citations Scopus - 2
2014 Springelkamp H, Höhn R, Mishra A, Hysi PG, Khor CC, Loomis SJ, et al., 'Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process', Nature Communications, 5 (2014) [C1]

© 2014 Macmillan Publishers Limited. All rights reserved. Glaucoma is characterized by irreversible optic nerve degeneration and is the most frequent cause of irreversible blindn... [more]

© 2014 Macmillan Publishers Limited. All rights reserved. Glaucoma is characterized by irreversible optic nerve degeneration and is the most frequent cause of irreversible blindness worldwide. Here, the International Glaucoma Genetics Consortium conducts a meta-analysis of genome-wide association studies of vertical cup-disc ratio (VCDR), an important disease-related optic nerve parameter. In 21,094 individuals of European ancestry and 6,784 individuals of Asian ancestry, we identify 10 new loci associated with variation in VCDR. In a separate risk-score analysis of five case-control studies, Caucasians in the highest quintile have a 2.5-fold increased risk of primary open-angle glaucoma as compared with those in the lowest quintile. This study has more than doubled the known loci associated with optic disc cupping and will allow greater understanding of mechanisms involved in this common blinding condition.

DOI 10.1038/ncomms5883
Citations Scopus - 17
Co-authors Rodney Scott, Liz Holliday
2014 Traylor M, Mäkelä KM, Kilarski LL, Holliday EG, Devan WJ, Nalls MA, et al., 'A novel MMP12 locus is associated with large artery atherosclerotic stroke using a genome-wide age-at-onset informed approach.', PLoS Genet, 10 e1004469 (2014) [C1]
DOI 10.1371/journal.pgen.1004469
Citations Scopus - 8Web of Science - 7
Co-authors Chris Levi, Liz Holliday, Jane Maguire
2014 Sotgia S, Zinellu A, Mangoni AA, Pintus G, Attia J, Carru C, McEvoy M, 'Clinical and biochemical correlates of serum L-ergothioneine concentrations in community-dwelling middle-aged and older adults', PLoS ONE, 9 (2014) [C1]

Background: Despite the increasing interest towards the biological role of L-ergothioneine, little is known about the serum concentrations of this unusual aminothiol in older adul... [more]

Background: Despite the increasing interest towards the biological role of L-ergothioneine, little is known about the serum concentrations of this unusual aminothiol in older adults. We addressed this issue in a representative sample of community-dwelling middle-aged and older adults. Methods: Body mass index, estimated glomerular filtration rate, serum concentrations of L-ergothioneine, taurine, homocysteine, cysteine, glutathione, cysteinylglycine, and glutamylcysteine were evaluated in 439 subjects (age 55-85 years) randomly selected from the Hunter Community Study. Results: Median L-ergothioneine concentration in the entire cohort was 1.01 IQR 0.78-1.33 µmol/L. Concentrations were not affected by gender (P = 0.41) or by presence of chronic medical conditions (P = 0.15). By considering only healthy subjects, we defined a reference interval for L-ergothioneine serum concentrations from 0.36 (90% CI 0.31-0.44) to 3.08 (90% CI 2.45-3.76) µmol/L. Using stepwise multiple linear regression analysis L-ergothioneine was negatively correlated with age (rpartial = 20.15; P = 0.0018) and with glutamylcysteine concentrations (rpartial = 20.13; P = 0.0063). Conclusions: A thorough analysis of serum L-ergothioneine concentrations was performed in a large group of community-dwelling middle-aged and older adults. Reference intervals were established. Age and glutamylcysteine were independently negatively associated with L-ergothioneine serum concentration. © 2014 Sotgia et al.

DOI 10.1371/journal.pone.0084918
Citations Scopus - 3Web of Science - 2
Co-authors Mark Mcevoy
2014 Vashum KP, McEvoy M, Milton AH, Islam MR, Hancock S, Attia J, 'Is serum zinc associated with pancreatic beta cell function and insulin sensitivity in pre-diabetic and normal individuals? Findings from the hunter community study', PLoS ONE, 9 (2014) [C1]

Aim: To determine if there is a difference in serum zinc concentration between normoglycaemic, pre-diabetic and type-2 diabetic groups and if this is associated with pancreatic be... [more]

Aim: To determine if there is a difference in serum zinc concentration between normoglycaemic, pre-diabetic and type-2 diabetic groups and if this is associated with pancreatic beta cell function and insulin sensitivity in the former 2 groups. Method: Cross sectional study of a random sample of older community-dwelling men and women in Newcastle, New South Wales, Australia. Beta cell function, insulin sensitivity and insulin resistance were calculated for normoglycaemic and prediabetes participants using the Homeostasis Model Assessment (HOMA-2) calculator. Result: A total of 452 participants were recruited for this study. Approximately 33% (N = 149) had diabetes, 33% (N = 151) had prediabetes and 34% (N = 152) were normoglycaemic. Homeostasis Model Assessment (HOMA) parameters were found to be significantly different between normoglycaemic and prediabetes groups (p<0.001). In adjusted linear regression, higher serum zinc concentration was associated with increased insulin sensitivity (p = 0.01) in the prediabetic group. There was also a significant association between smoking and worse insulin sensitivity. Conclusion: Higher serum zinc concentration is associated with increased insulin sensitivity. Longitudinal studies are required to determine if low serum zinc concentration plays a role in progression from pre-diabetes to diabetes. © 2014 Vashum et al.

DOI 10.1371/journal.pone.0083944
Citations Scopus - 6Web of Science - 3
Co-authors Milton Hasnat, Mark Mcevoy
2014 Evans TJ, Milne E, Anderson D, de Klerk NH, Jamieson SE, Talseth-Palmer BA, et al., 'Confirmation of childhood acute lymphoblastic leukemia variants, ARID5B and IKZF1, and interaction with parental environmental exposures.', PLoS One, 9 e110255 (2014) [C1]
DOI 10.1371/journal.pone.0110255
Citations Scopus - 4Web of Science - 2
Co-authors Liz Holliday, Nikola Bowden, Rodney Scott, Bente Talseth-Palmer
2014 White JH, Patterson K, Jordan L-A, Magin P, Attia J, Sturm JW, 'The experience of urinary incontinence in stroke survivors: A follow-up qualitative study', CANADIAN JOURNAL OF OCCUPATIONAL THERAPY-REVUE CANADIENNE D ERGOTHERAPIE, 81 124-134 (2014) [C1]
DOI 10.1177/0008417414527257
Co-authors Parker Magin
2014 White J, Dickson A, Magin P, Tapley A, Attia J, Sturm J, Carter G, 'Exploring the experience of psychological morbidity and service access in community dwelling stroke survivors: a follow-up study', DISABILITY AND REHABILITATION, 36 1600-1607 (2014) [C1]
DOI 10.3109/09638288.2013.859748
Citations Web of Science - 2
Co-authors Gregory Carter, Parker Magin
2014 Lai JS, Hiles S, Bisquera A, Hure AJ, McEvoy M, Attia J, 'A systematic review and meta-analysis of dietary patterns and depression in community-dwelling adults', AMERICAN JOURNAL OF CLINICAL NUTRITION, 99 181-197 (2014) [C1]
DOI 10.3945/ajcn.113.069880
Citations Scopus - 61Web of Science - 34
Co-authors Mark Mcevoy, Alexis Hure
2014 Holliday EG, Attia J, Hancock S, Koloski N, McEvoy M, Peel R, et al., 'Genome-wide association study identifies two novel genomic regions in irritable bowel syndrome', American Journal of Gastroenterology, 109 770-772 (2014) [C1]
DOI 10.1038/ajg.2014.56
Citations Scopus - 4Web of Science - 2
Co-authors Roseanne Peel, Nicholas Talley, Mark Mcevoy, Rodney Scott, Liz Holliday
2014 Ho YM, Smith SR, Pockney P, Lim P, Attia J, 'A Meta-analysis on the Effect of Sham Feeding Following Colectomy: Should Gum Chewing Be Included in Enhanced Recovery After Surgery Protocols?', DISEASES OF THE COLON & RECTUM, 57 115-126 (2014) [C1]
DOI 10.1097/DCR.0b013e3182a665be
Citations Scopus - 8Web of Science - 5
2014 Robertson J, Pearson S-A, Attia JR, 'How well do NSW hospital data identify cases of heart failure?', MEDICAL JOURNAL OF AUSTRALIA, 200 25-25 (2014) [C3]
DOI 10.5694/mja13.10207
Citations Scopus - 1
2014 Iseme RA, McEvoy M, Kelly B, Agnew L, Attia J, Walker FR, 'Autoantibodies and depression. Evidence for a causal link?', Neuroscience and Biobehavioral Reviews, 40 62-79 (2014) [C1]

Depression is a leading contributor to the global burden of diseases. Despite advances in research, challenges still exist in managing this disorder. Sufferers of autoimmune disea... [more]

Depression is a leading contributor to the global burden of diseases. Despite advances in research, challenges still exist in managing this disorder. Sufferers of autoimmune diseases are often observed to suffer from depression more often than healthy individuals, an association that cannot be completely accounted for by the impact of the disease on the individual. An association between autoimmunity and depressive symptoms also appears to exist in populations with subclinical symptoms. Moreover, researchers have successfully developed murine models illustrating the ability of autoantibodies to induce depressive-like symptoms. This paper will provide an overview of the association between autoantibodies and occurrence of depressive symptoms. Though current evidence appears to support a role for autoantibodies in the pathogenesis of depression, the majority of studies have examined this relationship cross-sectionally, therefore failing to establish a temporal association. Nonetheless, this novel theory meshes with older and newer neurochemical theories of depression. A better understanding of the immuno-pathogenesis underlying depression presents opportunities for more targeted treatment approaches and more timely and appropriate measures of detection. © 2014 Elsevier Ltd.

DOI 10.1016/j.neubiorev.2014.01.008
Citations Scopus - 10Web of Science - 4
Co-authors Brian Kelly, Rohan Walker, Mark Mcevoy
2014 Quilty S, Valler D, Attia J, 'Rural general physicians: Improving access and reducing costs of health care in the bush', Australian Health Review, 38 420-424 (2014) [C1]

Objective To assess the effectiveness of the introduction of a trainee specialist physician into the workforce mix of a rural hospital in the Northern Territory. Methods A retrosp... [more]

Objective To assess the effectiveness of the introduction of a trainee specialist physician into the workforce mix of a rural hospital in the Northern Territory. Methods A retrospective review comparing clinical and non-clinical outcomes during two corresponding 6-month periods in 2011 and 2012, before and after a FRACP Trainee in General and Acute Care Medicine commenced employment in the hospital. Results There was a significant reduction of 18% in total length of stay of admitted adult patients, with a 23% reduction of inter-hospital transfers and a 43% reduction of total aeromedical evacuations after the introduction of the trainee specialist. Although there was a 9% increase in patients presenting to the emergency department, there was a 9% reduction in total adult admissions. There was no change in the overall in-patient mortality rate; however, there was a significant change in the location of death, with an increase in patients dying in Katherine Hospital and a reciprocal decrease in death rate in those who had been transferred to Royal Darwin Hospital after the arrival of the trainee Conclusions The addition of an Advanced Trainee in General Medicine led to a significant change in the capacity of the hospital to care for unwell and complex patients. The role of the hospital in the care of dying patients was redefined and allowed many more people to pass away closer to their community and families. There were considerable savings at Katherine Hospital in terms of reduced bed pressure, reduced hospital bypass behaviour and reduced inter-hospital transfers, and these translated into significant benefits for the tertiary referral hospital in Darwin. A rural general physician can greatly value add to the capacity of a rural hospital and is a highly effective mechanism for reducing the disparities in healthcare access for rural and Indigenous patients. What is known about this topic? There is little research about the clinical and non-clinical impact of the addition of general speciality clinicians into the workforce of rural hospitals. Although there are several regional hospitals in Australia that have general specialists (i.e. emergency department physicians, general physicians and surgeons) and sub-specialists where the volume of patients is adequate to support such a workforce, there has been no published assessment of the impact of the addition of such speciality services. What does this paper add? This paper provides evidence of the cost-effectiveness of the addition of a specialist general physician to the workforce of a remote hospital servicing a large Indigenous population with very high burdens of acute and chronic illnesses in the Northern Territory. The paper demonstrates the potential to significantly add capacity to a rural or regional hospital by moving general speciality care to the hospital rather than, or in addition to, providing other methods of speciality and sub-speciality health care delivery. What are the implications for practitioners? The implications of this paper are that a significantly cost-effective means of addressing health care delivery to rural and remote populations is through the addition of appropriately trained general specialists such as emergency department physicians, general physicians and general surgeons. The implications extend to broader workforce development policies for education providers, speciality colleges and state and federal governments. © AHHA 2014.

DOI 10.1071/AH13197
Citations Scopus - 1
2014 Wang JJ, Buitendijk GHS, Rochtchina E, Lee KE, Klein BEK, Van Duijn CM, et al., 'Genetic susceptibility, dietary antioxidants, and long-term incidence of age-related macular degeneration in two populations', Ophthalmology, 121 667-675 (2014) [C1]

Objective To examine effect modification between genetic susceptibility to age-related macular degeneration (AMD) and dietary antioxidant or fish consumption on AMD risk. Design P... [more]

Objective To examine effect modification between genetic susceptibility to age-related macular degeneration (AMD) and dietary antioxidant or fish consumption on AMD risk. Design Pooled data analysis of population-based cohorts. Participants Participants from the Blue Mountains Eye Study (BMES) and Rotterdam Study (RS). Methods Dietary intakes of antioxidants (lutein/zeaxanthin [LZ], ß-carotene, and vitamin C), long-chain omega-3 polyunsaturated fatty acids, and zinc were estimated from food frequency questionnaires. The AMD genetic risk was classified according to the number of risk alleles of CFH (rs1061170) or ARMS2 (rs10490924) as low (no or 1 risk allele) or high (=2 risk alleles). Interactions between dietary intake and genetic risk levels were assessed. Associations between dietary intake and AMD risk were assessed comparing the highest with the 2 lower intake tertiles by genetic risk subgroups using discrete logistic regression, conducted in each study separately and then using pooled data. Participants without AMD lesions at any visit were controls. We adjusted for age and sex in analyses of each cohort sample and for smoking status and study site in pooled-data analyses. Main Outcome Measures All 15-year incident late AMD cases were confirmed by chief investigators of the Beaver Dam Eye Study, BMES, and RS. Intergrader reproducibility was assessed in an early AMD subsample, with 86.4% agreement between BMES and RS graders, allowing for a 1-step difference on a 5-step AMD severity scale. Results In pooled data analyses, we found significant interaction between AMD genetic risk status and LZ intake (P = 0.0009) but nonsignificant interactions between genetic risk status and weekly fish consumption (P = 0.05) for risk of any AMD. Among participants with high genetic risk, the highest intake tertile of LZ was associated with a >20% reduced risk of early AMD, and weekly consumption of fish was associated with a 40% reduced risk of late AMD. No similar association was evident among participants with low genetic risk. No interaction was detected between ß-carotene or vitamin C and genetic risk status. Conclusions Protection against AMD from greater LZ and fish consumption in persons with high genetic risk based on 2 major AMD genes raises the possibility of personalized preventive interventions. ©2014 by the American Academy of Ophthalmology.

DOI 10.1016/j.ophtha.2013.10.017
Citations Scopus - 14Web of Science - 13
Co-authors Wayne Smith, Liz Holliday
2014 Greenop KR, de Klerk NH, Bower C, Milne E, Miller M, Scott RJ, et al., 'Maternal Dietary Intake of Folate and Vitamins B6 and B12 During Pregnancy and Risk of Childhood Brain Tumors', Nutrition and Cancer, (2014) [C1]

Childhood brain tumors (CBT) are the second most common childhood cancers, yet their etiology is largely unknown. We investigated whether maternal gestational intake of folate and... [more]

Childhood brain tumors (CBT) are the second most common childhood cancers, yet their etiology is largely unknown. We investigated whether maternal gestational intake of folate and vitamins B6 and B12 was associated with CBT risk in a nationwide case-control study conducted 2005-2010. Case children 0-14 years were recruited from all 10 Australian pediatric oncology centers. Control children were recruited by national random digit dialing, frequency matched to cases on age, sex, and state of residence. Dietary intake was ascertained using food frequency questionnaires and adjusted for total energy intake. Data from 293 case and 726 control mothers were analyzed using unconditional logistic regression. The odds ratio (OR) for the highest versus lowest tertile of folate intake was 0.70 [95% confidence interval (CI): 0.48, 1.02]. The ORs appeared lower in mothers who drank alcohol during pregnancy (OR = 0.45, 95% CI: 0.22, 0.93), mothers who took folic acid (OR = 0.67, 95% CI: 0.42, 1.06) or B6/B12 supplements (OR = 0.51, 95% CI: 0.25, 1.06) and in children younger than 5 years (OR = 0.50, 95% CI: 0.27, 0.93). These findings are consistent with folate's crucial role in maintenance of genomic integrity and DNA methylation. Dietary intake of B6 and B12 was not associated with risk of CBT. © 2014 Copyright © Taylor & Francis Group, LLC.

DOI 10.1080/01635581.2014.916326
Citations Scopus - 9Web of Science - 5
Co-authors Rodney Scott
2014 Thakkinstian A, Chailurkit L, Warodomwichit D, Ratanachaiwong W, Yamwong S, Chanprasertyothin S, et al., 'Causal relationship between body mass index and fetuin-A level in the asian population: A bidirectional mendelian randomization study', Clinical Endocrinology, 81 197-203 (2014) [C1]

Objective Fetuin-A is associated with body mass index (BMI) as well as components of the metabolic syndrome. However, it is unclear if fetuin-A affects BMI or the other way around... [more]

Objective Fetuin-A is associated with body mass index (BMI) as well as components of the metabolic syndrome. However, it is unclear if fetuin-A affects BMI or the other way around. We therefore assessed the causal association between fetuin-A and BMI or vice versa, utilizing a bidirectional Mendelian randomization approach. Design and Methods This was a study of 2558 subjects from the Electricity Generating Authority of Thailand (EGAT) cohort. Two polymorphisms, that is, rs2248690 in the alpha2-Hereman-Schmid glycoprotein (AHSG) gene and rs9939609 in the fat mass and obesity-Associated (FTO) gene were genotyped. Bidirectional causal models were constructed using a two-stage least-square instrumental variable (IV) regression. First, rs2248690 locus was used as the instrumental variable for the effect of circulating fetuin-A on BMI, and then, the FTO rs9939609 locus was used as the instrumental variable for the effect of BMI on circulating fetuin-A. Results Among the 2558 subjects, the prevalence of the minor AHSG (T) and FTO (A) alleles was 17·9% and 22·1%, respectively. The AHSG rs2248690 locus was highly related to serum fetuin-A levels (P < 0·001). Likewise, the FTO rs9939609 locus and BMI were highly associated (P < 0·001). Mendelian randomization analyses showed that circulating fetuin-A, instrumented by the AHSG rs2248690 locus, was associated with BMI (coefficient = 2·26; 95% CI: 0·39, 4·12). In contrast, BMI, instrumented by the FTO rs9939609 locus, was not associated with circulating fetuin-A (coefficient = 0·0007; 95% CI: -0·0242, 0·0256). Conclusion Our findings suggest a causal association leading from circulating fetuin-A to BMI. There was no evidence of reverse causality from BMI to fetuin-A. © 2013 John Wiley & Sons Ltd.

DOI 10.1111/cen.12303
Citations Scopus - 7Web of Science - 6
2014 Joshy G, Korda RJ, Attia J, Liu B, Bauman AE, Banks E, 'Body mass index and incident hospitalisation for cardiovascular disease in 158 546 participants from the 45 and Up Study', International Journal of Obesity, 38 848-856 (2014) [C1]

Objective: To investigate the relationship between fine gradations in body mass index (BMI) and risk of hospitalisation for different types of cardiovascular disease (CVD). Design... [more]

Objective: To investigate the relationship between fine gradations in body mass index (BMI) and risk of hospitalisation for different types of cardiovascular disease (CVD). Design, Subjects and Methods: The 45 and Up Study is a large-scale Australian cohort study initiated in 2006. Self-reported data from 158 546 individuals with no history of CVD were linked prospectively to hospitalisation and mortality data. Hazard ratios (HRs) of incident hospitalisation for specific CVD diagnoses in relation to baseline BMI categories were estimated using Cox regression, adjusting for age, sex, region of residence, income, education, smoking, alcohol intake and health insurance status. Results: There were 9594 incident CVD admissions over 583 100 person-years among people with BMI=20 kg m-2, including 3096 for ischaemic heart disease (IHD), 1373 for stroke, 411 for peripheral vascular disease (PVD) and 320 for heart failure. The adjusted HR of hospitalisation for all CVD diagnoses combined increased significantly with increasing BMI (P(trend) <0.0001)). The HR of IHD hospitalisation increased by 23% (95% confidence interval (95% CI): 18-27%) per 5 kg m-2 increase in BMI (compared to BMI 20.0-22.49 kg m-2, HR (95% CI) for BMI categories were: 22.5-24.99=1.25 (1.08-1.44); 25-27.49=1.43 (1.24-1.65); 27.5-29.99=1.64 (1.42-1.90); 30-32.49=1.63 (1.39-1.91) and 32.5-50=2.10 (1.79-2.45)). The risk of hospitalisation for heart failure showed a significant, but nonlinear, increase with increasing BMI. No significant increase was seen with above-normal BMI for stroke or PVD. For other specific classifications of CVD, HRs of hospitalisation increased significantly with increasing BMI for: hypertension; angina; acute myocardial infarction; chronic IHD; pulmonary embolism; non-rheumatic aortic valve disorders; atrioventricular and left bundle-branch block; atrial fibrillation and flutter; aortic aneurysm; and phlebitis and thrombophlebitis. Conclusion: The risk of hospitalisation for a wide range of CVD subtypes increases with relatively fine increments in BMI. Obesity prevention strategies are likely to benefit from focusing on bringing down the mean BMI at the population level, in addition to targeting those with a high BMI. © 2014 Macmillan Publishers Limited All rights reserved.

DOI 10.1038/ijo.2013.192
Citations Scopus - 7Web of Science - 4
2014 De Vivo I, Prescott J, Setiawan VW, Olson SH, Wentzensen N, Attia J, et al., 'Genome-wide association study of endometrial cancer in E2C2', HUMAN GENETICS, 133 211-224 (2014) [C1]
DOI 10.1007/s00439-013-1369-1
Citations Scopus - 10Web of Science - 9
Co-authors Rodney Scott, Mark Mcevoy, Liz Holliday
2014 Williams FMK, Carter AM, Hysi PG, Surdulescu G, Hodgkiss D, Soranzo N, et al., 'Ischemic stroke is associated with the ABO locus: The EuroCLOT study (vol 73, pg 16, 2013)', ANNALS OF NEUROLOGY, 75 166-167 (2014)
DOI 10.1002/ana.24105
Co-authors Chris Levi, Rodney Scott, Liz Holliday
2014 Woratanarat P, Thaveeratitharm C, Woratanarat T, Angsanuntsukh C, Attia J, Thakkinstian A, 'Meta-analysis of hypercoagulability genetic polymorphisms in perthes disease', Journal of Orthopaedic Research, 32 1-7 (2014) [C1]

Perthes disease is an osteonecrosis of the femoral epiphysis with unclear etiology. This study aimed to systematically review the association between genetic determinants of hyper... [more]

Perthes disease is an osteonecrosis of the femoral epiphysis with unclear etiology. This study aimed to systematically review the association between genetic determinants of hypercoagulability (Factor V Leiden, prothrombin II, and methylenetetrahydrofolate reductase; MTHFR) and Perthes disease. PubMed and Scopus searched from inception to January 2012, data extraction and quality assessment were performed. The odds ratio (OR) for the allele effect was pooled, and heterogeneity and publication bias were assessed. Twelve case-control studies met inclusion criteria and had sufficient data for extraction. There were 824 cases and 2,033 controls with a mean age range of 6.1-14.7 years. The prevalence of the minor allele in controls was 0.015 (95% confidence interval (CI): 0.008, 0.023), 0.012 (95% CI: 0.008, 0.017), and 0.105 (95% CI: 0.044, 0.167) for factor V Leiden, prothrombin II, and MTHFR, respectively. The factor V Leiden allele increased the risk of Perthes with a pooled OR of 3.10 (95% CI: 1.68, 5.72), while prothrombin II and MTHFR had non-significantly pooled OR 1.48 (95% CI: 0.71, 3.08), and 0.97 (95% CI: 0.72, 1.30), respectively. The factor V Leiden mutation is significantly related to Perthes disease, and its screening in at-risk children might be useful in the future. © 2013 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.

DOI 10.1002/jor.22473
Citations Scopus - 8Web of Science - 4
2014 Handley TE, Kay-Lambkin FJ, Inder KJ, Attia JR, Lewin TJ, Kelly BJ, 'Feasibility of internet-delivered mental health treatments for rural populations', Social Psychiatry and Psychiatric Epidemiology, 49 275-282 (2014) [C1]

Purpose: Rural populations face numerous barriers to mental health care. Although internet-delivered mental health treatments may offer an accessible and cost-effective answer to ... [more]

Purpose: Rural populations face numerous barriers to mental health care. Although internet-delivered mental health treatments may offer an accessible and cost-effective answer to these barriers, there has been little evaluation of the feasibility of this approach among rural communities. Methods: Data were obtained from a random rural community sample through the third wave of the Australian Rural Mental Health Study. Attitudes towards internet-delivered mental health treatments and availability of internet access were explored. Data were analysed to identify sub-groups in whom internet-delivered treatments may be usefully targeted. Results: Twelve hundred and forty-six participants completed the survey (mean age 59 years, 61 % females, 22 % from remote areas). Overall, 75 % had internet access and 20 % would consider using internet-based interventions, with 18 % meeting both of these feasibility criteria. Logistic regression revealed feasibility for internet-delivered mental health treatment was associated with younger age, male gender, being a carer, and a 12-month mental health problem. Participants who had used internet-delivered services in the past were significantly more likely to endorse these treatments as acceptable. Conclusions: There is considerable potential for internet-delivered treatments to increase service accessibility to some sub-groups, particularly among people with mental health problems who are not currently seeking help. Resistance to internet treatments appears to be largely attitudinal, suggesting that enhancing community education and familiarity with such programs may be effective in improving perceptions and ultimately access. © 2013 Springer-Verlag Berlin Heidelberg.

DOI 10.1007/s00127-013-0708-9
Citations Scopus - 4Web of Science - 5
Co-authors Kerry Inder, Terry Lewin, Brian Kelly
2014 Greenop KR, Peters S, Bailey HD, Fritschi L, Attia J, Scott RJ, et al., 'Exposure to pesticides and the risk of childhood brain tumors (vol 24, pg 1269, 2013)', CANCER CAUSES & CONTROL, 25 1239-1240 (2014) [O1]
DOI 10.1007/s10552-014-0418-y
Co-authors Rodney Scott
2014 Greenop KR, Miller M, Attia J, Ashton LJ, Cohn R, Armstrong BK, Milne E, 'Maternal consumption of coffee and tea during pregnancy and risk of childhood brain tumors: results from an Australian case-control study', Cancer Causes & Control, (2014) [C1]

Purpose The causes of childhood brain tumors (CBT) are largely unknown, but gestational diet may influence this risk. The aim of this analysis was to investigate whether maternal ... [more]

Purpose The causes of childhood brain tumors (CBT) are largely unknown, but gestational diet may influence this risk. The aim of this analysis was to investigate whether maternal coffee or tea consumption during pregnancy was associated with the risk of CBT. Methods The Australian Study of the Causes of Childhood Brain Tumours was a population-based, Australian case-control study conducted between 2005 and 2010. Case children were recruited from 10 pediatric oncology centers and control children by nationwide random-digit dialing, frequency matched to cases on the basis of age, sex and state of residence. Coffee and tea intake were assessed using a food frequency questionnaire. Results Data on coffee and tea consumption during pregnancy were available from 293 case mothers and 726 control mothers. Odds ratios (ORs) and confidence intervals (CIs) were calculated using multivariable unconditional logistic regression. There was little evidence of an association between gestational consumption of any coffee (OR 1.23, 95 % CI 0.92, 1.64) or tea (OR 1.00, 95 % CI 0.74, 1.36) and CBT risk. Among children aged under 5 years, the OR for any coffee consumption during pregnancy was 1.76 (95 % CI 1.09, 2.84) and for =2 cups per day during pregnancy was 2.52 (95 % CI 1.26, 5.04). There was little evidence that associations with coffee or tea intake differed by parental smoking status. Conclusions These results suggest a positive association between coffee intake =2 cups per day and risk of CBT in younger children, although some estimates are imprecise. There was no association between maternal tea drinking and risk of CBT. © 2014 Springer International Publishing Switzerland.

DOI 10.1007/s10552-014-0437-8
Citations Scopus - 1
2014 Milne E, Greenop KR, Fritschi L, Attia J, Bailey HD, Scott RJ, et al., 'Childhood and parental diagnostic radiological procedures and risk of childhood brain tumors', Cancer Causes and Control, 25 375-383 (2014) [C1]

Purpose: Childhood brain tumors (CBT) are the second most common type of childhood cancer and the leading cause of childhood cancer mortality. Few causes of CBT are known, but par... [more]

Purpose: Childhood brain tumors (CBT) are the second most common type of childhood cancer and the leading cause of childhood cancer mortality. Few causes of CBT are known, but parental, fetal, and early life exposures are likely to be important given the early age at diagnosis of many cases. We aimed to investigate whether parents' diagnostic radiological procedures before conception, in the mother during pregnancy or the child's procedures were associated with an increased risk of CBT. Methods: This population-based case-control study was conducted between 2005 and 2010. Cases were identified through all ten Australian pediatric oncology centers, and controls via nationwide random-digit dialing; frequency-matched to cases on age, sex and state of residence. Information on radiological exposures in the time periods of interest was obtained for 306 case and 950 control families through mailed questionnaires. Analysis used unconditional logistic regression, adjusting for matching variables and potential confounders. Results: We found no evidence of positive associations between risk of CBT overall and childhood or parental pre-pregnancy radiological procedures. Increased ORs for high-grade gliomas associated with childhood radiological procedures were based on small numbers and may be due to chance. Conclusions: Given the evidence for an increased risk of CBT in cohort studies of computed tomography (CT) in childhood, the lack of such an association in our study may be due to the reduced intensity of CTs after 2001. Future research to investigate the safety of fetal exposure to more intense procedures like CT scans is needed. © 2014 Springer International Publishing Switzerland.

DOI 10.1007/s10552-014-0338-x
Citations Scopus - 1Web of Science - 1
Co-authors Rodney Scott
2014 Bailey HD, Miller M, Greenop KR, Bower C, Attia J, Marshall GM, et al., 'Paternal intake of folate and vitamins B6 and B12 before conception and risk of childhood acute lymphoblastic leukemia', Cancer Causes and Control, 25 1615-1625 (2014) [C1]

© 2014, Springer International Publishing Switzerland. Purpose: We investigated whether paternal dietary intake of folate before conception is associated with the risk of childho... [more]

© 2014, Springer International Publishing Switzerland. Purpose: We investigated whether paternal dietary intake of folate before conception is associated with the risk of childhood acute lymphoblastic leukemia (ALL) in a nationwide case¿control study. Methods: Data on dietary folate intake during the 6¿months before the child¿s conception were collected from 285 case fathers and 595 control fathers using a dietary questionnaire. Nutrient intake was quantified using a customized computer software package based on Australian food composition databases. Data on folate intake were analyzed using unconditional logistic regression, adjusting for study-matching variables, total energy, and potentially confounding variables. In a subset of 229 cases and 420 controls, data on vitamin B6 and vitamin B12 intake were also analyzed. Results: No consistent associations were seen with paternal dietary intake of folate or vitamin B6. Higher levels of paternal dietary vitamin B12 were appeared to be associated with an increased risk of childhood ALL, with those in the highest tertile of consumption having an OR of 1.51 (0.97, 2.36). The use of supplements containing folate and vitamins B6 or B12 was rare. Conclusions: We did not find any biologically plausible evidence that paternal nutrition in the period leading up to conception was associated with childhood ALL. Our finding for vitamin B12 may be a chance finding, given the number of analyses performed, or be attributable to participation bias because parents with a tertiary education had the lowest level of B12 intake and tertiary education was more common among control than case parents.

DOI 10.1007/s10552-014-0466-3
Citations Scopus - 2
2014 White JH, Attia J, Sturm J, Carter G, Magin P, 'Predictors of depression and anxiety in community dwelling stroke survivors: A cohort study', Disability and Rehabilitation, 36 1975-1982 (2014) [C1]

© 2014 Informa UK Ltd. Purpose: Few longitudinal studies explore post-stroke patterns of psychological morbidity and factors contributing to their change over time. We aimed to e... [more]

© 2014 Informa UK Ltd. Purpose: Few longitudinal studies explore post-stroke patterns of psychological morbidity and factors contributing to their change over time. We aimed to explore predictors of post-stroke depression (PSD) and post-stroke anxiety over a 12-month period. Methods: A prospective cohort study. Consecutively recruited stroke patients (n=134) participated in face-to-face interviews at baseline, 3, 6, 9, and 12 months. Primary outcome measures were depression and anxiety (measured via Hospital Anxiety and Depression Scale). Independent variables included disability (Modified Rankin Scale), Quality-of-life (Assessment Quality-of-life), social support (Multi-dimensional Scale Perceived Social Support) and community participation (Adelaide Activities Profile (AAP)). Secondary outcomes were predictors of resolution and development of PSD and anxiety. Results: Anxiety (47%) was more common than depression (22%) at baseline. Anxiety (but not depression) scores improved over time. Anxiety post-stroke was positively associated with baseline PSD (p<0.0001), baseline anxiety (p<0.0001) and less disability (p=0.042). PSD was associated with baseline anxiety (p<0.0001), baseline depression (p=0.0057), low social support (p=0.0161) and low community participation (p<0.0001). The only baseline factor predicting the resolution of PSD (if depressed at baseline) was increased social support (p=0.0421). Factors that predicted the onset of depression (if not depressed at baseline) were low community participation (p=0.0015) and higher disability (p=0.0057). Conclusion: While more common than depression immediately post-stroke, anxiety attenuates while the burden of depression persists over 12 months. Clinical programs should assess anxiety and depression, provide treatment pathways for those identified, and address modifiable risk factors, especially social support and social engagement.Implications for RehabilitationPsychological distress post stroke is persisting.Multi-disciplinary teams that establish goals with patients promoting social and community engagement could assist in managing psychological morbidity.A shift towards promoting longer-term monitoring and management of stroke survivors must be undertaken, and should consider the factors that support and hinder psychological morbidity.

DOI 10.3109/09638288.2014.884172
Citations Scopus - 3Web of Science - 1
Co-authors Parker Magin, Gregory Carter
2014 Moayyeri A, Hsu Y-H, Karasik D, Estrada K, Xiao S-M, Nielson C, et al., 'Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium', HUMAN MOLECULAR GENETICS, 23 3054-3068 (2014) [C1]
DOI 10.1093/hmg/ddt675
Citations Scopus - 21Web of Science - 6
Co-authors Rodney Scott, Liz Holliday, Christopher Oldmeadow, Roseanne Peel, Mark Mcevoy
2014 Wilasrusmee C, Marjareonrungrung M, Eamkong S, Attia J, Poprom N, Jirasisrithum S, Thakkinstian A, 'Maggot therapy for chronic ulcer: A retrospective cohort and a meta-analysis', ASIAN JOURNAL OF SURGERY, 37 138-147 (2014) [C1]
DOI 10.1016/j.asjsur.2013.09.005
Citations Web of Science - 1
2014 Loth DW, Artigas MS, Gharib SA, Wain LV, Franceschini N, Koch B, et al., 'Genome-wide association analysis identifies six new loci associated with forced vital capacity', NATURE GENETICS, 46 669-677 (2014) [C1]
DOI 10.1038/ng.3011
Citations Scopus - 19Web of Science - 14
Co-authors Liz Holliday, Rodney Scott, Christopher Oldmeadow
2014 Wilasrusmee C, Anothaisintawee T, Poprom N, McEvoy M, Attia J, Thakkinstian A, 'Diagnostic Scores for Appendicitis: A Systematic Review of Scores¿ Performance', British Journal of Medicine and Medical Research, 4 711-730 (2014) [C1]
DOI 10.9734/BJMMR/2014/5255
Co-authors Mark Mcevoy
2014 Handley TE, Hiles SA, Inder KJ, Kay-Lambkin FJ, Kelly BJ, Lewin TJ, et al., 'Predictors of Suicidal Ideation in Older People: A Decision Tree Analysis', AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY, 22 1325-1335 (2014) [C1]
DOI 10.1016/j.jagp.2013.05.009
Citations Scopus - 5Web of Science - 2
Co-authors Roseanne Peel, Mark Mcevoy, Brian Kelly, Terry Lewin, Kerry Inder
2014 Holliday EG, Traylor M, Malik R, Bevan S, Maguire J, Koblar SA, et al., 'Polygenic Overlap Between Kidney Function and Large Artery Atherosclerotic Stroke', STROKE, 45 3508-+ (2014) [C1]
DOI 10.1161/STROKEAHA.114.006609
Co-authors Chris Levi, Jane Maguire, Christopher Oldmeadow, Mark Mcevoy, Liz Holliday, Rodney Scott
2014 Williams D, Conn J, Talley N, Attia J, 'Reviewing the evidence base for the peripheral sensory examination', International Journal of Clinical Practice, 68 756-760 (2014) [C1]

Background Many students find the peripheral sensory examination confusing. We set out to summarise the evidence base in order to provide guidance on the most useful manoeuvres. M... [more]

Background Many students find the peripheral sensory examination confusing. We set out to summarise the evidence base in order to provide guidance on the most useful manoeuvres. Methods We performed a literature review starting with 5 secondary sources, supplemented by a literature search on MEDLINE. Results A useful approach to neuropathy is to divide these into large fibre sensory neuropathy (LFSN) in which vibration and proprioception are affected, and small fibre sensory neuropathy (SFSN) in which pain and temperature are affected. Positive sensory symptoms such as burning, electric or sunburn pain point to a SFSN; negative symptoms such as loss of sensation, numbness or deep pain point to a LFSN. If LFSN is suspected, the most reproducible and best studied physical examination is a 10g monofilament, but vibration sense is also useful. There is much less data on the best physical examination for a SFSN. The most appropriate diagnostic test for SFSN is quantitative sensory testing, whereas for LFSN a nerve conduction study is indicated. Conclusions A modest amount of evidence is available to guide peripheral sensory examination but more research is needed. © 2014 John Wiley & Sons Ltd.

DOI 10.1111/ijcp.12389
Co-authors Nicholas Talley
2014 Oldmeadow C, Holliday EG, McEvoy M, Scott R, Kwok JBJ, Mather K, et al., 'Concordance between direct and imputed APOE genotypes using 1000 genomes data', Journal of Alzheimer's Disease, 42 391-393 (2014) [C1]

© 2014 - IOS Press and the authors. All rights reserved. There are a growing number of large cohorts of older persons with genome-wide genotyping data available, but APOE is not ... [more]

© 2014 - IOS Press and the authors. All rights reserved. There are a growing number of large cohorts of older persons with genome-wide genotyping data available, but APOE is not included in any of the common microarray platforms. We compared directly measured APOE genotypes with those imputed using microarray data and the '1000 Genomes' dataset in a sample of 320 Caucasians. We find 90% agreement for e2/e3/e4 genotypes and 93% agreement for predicting e4 status, yielding kappa values of 0.81 and 0.84, respectively. More stringent thresholds around allele number estimates can increase this agreement to 90-97% and kappas of 0.90-0.93.

DOI 10.3233/JAD-140846
Co-authors Christopher Oldmeadow, Mark Mcevoy, Rodney Scott, Liz Holliday, Peter Schofield
2014 Gunathilake R, Krishnamurthy V, Oldmeadow C, Kerr E, Padmakumar C, Attia J, et al., 'Relationships between age, other predictive variables, and the 90-day functional outcome after intravenous thrombolysis for acute ischemic stroke', AUSTRALASIAN JOURNAL ON AGEING, 33 19-19 (2014) [E3]
Co-authors Mark Parsons, Christopher Oldmeadow, Chris Levi
2014 Muenchhoff J, Poljak A, Song F, Raftery M, Brodaty H, Duncan M, et al., 'Plasma protein profiling of mild cognitive impairment and Alzheimer's disease across two independent cohorts', Journal of Alzheimer's Disease, 43 1355-1373 (2014) [C1]

© 2015 - IOS Press and the authors. To unlock the full potential of disease modifying treatments, it is essential to develop early biomarkers for Alzheimer's disease (AD). For pr... [more]

© 2015 - IOS Press and the authors. To unlock the full potential of disease modifying treatments, it is essential to develop early biomarkers for Alzheimer's disease (AD). For practical reasons, blood-based markers that could provide a signal at the stage of mild cognitive impairment (MCI) or even earlier would be ideal. Using the proteomic approach of isobaric tagging for relative and absolute quantitation (iTRAQ), we compared the plasma protein profiles of MCI, AD, and cognitively normal control subjects from two independent cohorts: the Sydney Memory and Ageing Study (261 MCI subjects, 24 AD subjects, 411 controls) and the Hunter Community Study (180 MCI subjects, 153 controls). The objective was to identify any proteins that are differentially abundant in MCI and AD plasma in both cohorts, since they might be of interest as potential biomarkers, or could help direct future mechanistic studies. Proteins representative of biological processes relevant to AD pathology, such as the complement system, the coagulation cascade, lipid metabolism, and metal and vitamin D and E transport, were found to differ in abundance in MCI. In particular, levels of complement regulators C1 inhibitor and factor H, fibronectin, ceruloplasmin, and vitamin D-binding protein were significantly decreased in MCI participants from both cohorts. Several apolipoproteins, including apolipoprotein AIV, B-100, and H were also significantly decreased in MCI. Most of these proteins have previously been reported as potential biomarkers for AD; however, we show for the first time that a significant decrease in plasma levels of two potential biomarkers (fibronectin and C1 inhibitor) is evident at the MCI stage.

DOI 10.3233/JAD-141266
Citations Scopus - 7Web of Science - 1
Co-authors Mark Mcevoy, Peter Schofield
2014 Tarrant SM, Hardy BM, Byth PL, Brown TL, Attia J, Balogh ZJ, 'Preventable mortality in geriatric hip fracture inpatients', Bone and Joint Journal, 69B 1178-1184 (2014) [C1]

© 2014 The British Editorial Society of Bone & Joint Surgery. There is a high rate of mortality in elderly patients who sustain a fracture of the hip. We aimed to determine the r... [more]

© 2014 The British Editorial Society of Bone & Joint Surgery. There is a high rate of mortality in elderly patients who sustain a fracture of the hip. We aimed to determine the rate of preventable mortality and errors during the management of these patients. A 12 month prospective study was performed on patients aged > 65 years who had sustained a fracture of the hip. This was conducted at a Level 1 Trauma Centre with no orthogeriatric service. A multidisciplinary review of the medical records by four specialists was performed to analyse errors of management and elements of preventable mortality. During 2011, there were 437 patients aged > 65 years admitted with a fracture of the hip (85 years (66 to 99)) and 20 died while in hospital (86.3 years (67 to 96)). A total of 152 errors were identified in the 80 individual reviews of the 20 deaths. A total of 99 errors (65%) were thought to have at least a moderate effect on death; 45 reviews considering death (57%) were thought to have potentially been preventable. Agreement between the panel of reviewers on the preventability of death was fair. A larger-scale assessment of preventable mortality in elderly patients who sustain a fracture of the hip is required. Multidisciplinary review panels could be considered as part of the quality assurance process in the management of these patients.

DOI 10.1302/0301-620X.96B9.32814$2.00
Citations Scopus - 6Web of Science - 3
Co-authors Zsolt Balogh
2014 Lai JS, Attia JR, McEvoy M, Hure AJ, 'Biochemical Validation of the Older Australian¿s Food Frequency Questionnaire Using Carotenoids and Vitamin E', Nutrients, 6 4906-4917 (2014) [C1]
DOI 10.3390/nu6114906
Citations Scopus - 2
Co-authors Mark Mcevoy, Alexis Hure
2014 Denham JW, Joseph D, Lamb DS, Spry NA, Duchesne G, Matthews J, et al., 'Short-term androgen suppression and radiotherapy versus intermediate-term androgen suppression and radiotherapy, with or without zoledronic acid, in men with locally advanced prostate cancer (TROG 03.04 RADAR): an open-label, randomised, phase 3 factorial trial', LANCET ONCOLOGY, 15 1076-1089 (2014) [C1]
DOI 10.1016/S1470-2045(14)70328-6
Citations Scopus - 21Web of Science - 4
Co-authors Christopher Oldmeadow, Jim Denham, Allison Steigler
2014 Islam MR, Attia J, Alauddin M, McEvoy M, McElduff P, Slater C, et al., 'Availability of arsenic in human milk in women and its correlation with arsenic in urine of breastfed children living in arsenic contaminated areas in Bangladesh.', Environmental Health: A Global Access Science Source, 13 1-10 (2014) [C1]
Co-authors Wayne Smith, Catherine Deste, Roseanne Peel, Mark Mcevoy, Milton Hasnat
2014 Johnson NA, Kypri K, Latter J, McElduff P, Saunders JB, Saitz R, et al., 'Prevalence of unhealthy alcohol use in hospital outpatients', Drug and Alcohol Dependence, 144 270-273 (2014) [C1]

© 2014 Elsevier Ireland Ltd. Background: Few studies have examined the prevalence of unhealthy alcohol use in the hospital outpatient setting. Our aim was to estimate the prevale... [more]

© 2014 Elsevier Ireland Ltd. Background: Few studies have examined the prevalence of unhealthy alcohol use in the hospital outpatient setting. Our aim was to estimate the prevalence of unhealthy alcohol use among patients attending a broad range of outpatient clinics at a large public hospital in Australia. Methods: Adult hospital outpatients were invited to complete the Alcohol Use Disorders Identification Test Consumption questions (AUDIT-C) using an iPad as part of a randomised trial testing the efficacy of alcohol electronic screening and brief intervention. Unhealthy alcohol use was defined as an AUDIT-C score =5 among men and =4 among women. Results: Sixty percent (3616/6070) of invited hospital outpatients consented, of whom 89% (3206/3616) provided information on their alcohol consumption (either reported they had not consumed any alcohol in the last 12 months or completed the AUDIT-C). The prevalence of unhealthy alcohol use was 34.7% (95% confidence interval [CI]: 33.0-36.3%). The prevalence among men aged 18-24 years, 25-39 years, 40-59 years and 60 years and older, was 74.4% (95% CI: 68.4-80.4%), 54.3% (95% CI: 48.7-59.8%), 44.1% (95% CI: 39.9-48.3%), and 27.0% (95% CI: 23.6-30.4%), respectively (43.1% overall; 95% CI: 40.8-45.5%). The prevalence among women aged 18-24 years, 25-39 years, 40-59 years, and 60 years and older, was 48.6% (95% CI: 39.2-58.1%), 36.9% (95% CI: 31.2-42.6%), 25.2% (95% CI: 21.5-29.0%) and 14.5% (95% CI: 11.7-17.3%), respectively (24.9% overall; 95% CI: 22.7-27.1%). Conclusion: A large number of hospital outpatients who are not currently seeking treatment for their drinking could benefit from effective intervention in this setting.

DOI 10.1016/j.drugalcdep.2014.08.014
Citations Scopus - 1
Co-authors Natalie Johnson, Luke Wolfenden, Kypros Kypri, Adrian Dunlop, Joanna Latter
2014 Ewald B, Attia J, McElduff P, 'How many steps are enough? dose-response curves for pedometer steps and multiple health markers in a community-based sample of older Australians', Journal of Physical Activity and Health, 11 509-518 (2014) [C1]

Background: Although an overall public health target of 10,000 steps per day has been advocated, the dose-response relationship for each health benefit of physical activity may di... [more]

Background: Although an overall public health target of 10,000 steps per day has been advocated, the dose-response relationship for each health benefit of physical activity may differ. Methods: A representative community sample of 2458 Australian residents aged 55-85 wore a pedometer for a week in 2005-2007 and completed a health assessment. Age-standardized steps per day were compared with multiple markers of health using locally weighted regression to produce smoothed dose-response curves and then to select the steps per day matching 60% or 80% of the range in each health marker. Results: There is a linear relationship between activity level and markers of inflammation throughout the range of steps per day; this is also true for BMI in women and high density lipoprotein in men. For other markers, including waist:hip ratio, fasting glucose, depression, and SF-36 scores, the benefit of physical activity is mostly in the lower half of the distribution. Conclusions: Older adults have no plateau in the curve for some health outcomes, even beyond 12,000 steps per day. For other markers, however, there is a threshold effect, indicating that most of the benefit is achieved by 8000 steps per day, supporting this as a suitable public health target for older adults. © 2014 Human Kinetics, Inc.

DOI 10.1123/jpah.2012-0091
Citations Scopus - 5Web of Science - 3
Co-authors Ben Ewald
2014 McEvoy M, Schofield P, Smith W, Agho K, Mangoni AA, Soiza RL, et al., 'Memory Impairment is Associated with Serum Methylarginines in Older Adults', CURRENT ALZHEIMER RESEARCH, 11 97-106 (2014) [C1]
Citations Scopus - 4Web of Science - 3
Co-authors Peter Schofield, Wayne Smith, Mark Mcevoy, Roseanne Peel
2014 Greenop KR, Peters S, Bailey HD, Fritschi L, Attia J, Scott RJ, et al., 'Erratum to: Exposure to pesticides and the risk of childhood brain tumors', Cancer Causes and Control, 25 1239-1240 (2014)
DOI 10.1007/s10552-014-0418-y
Co-authors Rodney Scott
2014 Abdullah N, Attia J, Oldmeadow C, Scott RJ, Holliday EG, 'The Architecture of Risk for Type 2 Diabetes: Understanding Asia in the Context of Global Findings', INTERNATIONAL JOURNAL OF ENDOCRINOLOGY, (2014) [C1]
DOI 10.1155/2014/593982
Citations Scopus - 10Web of Science - 1
Co-authors Christopher Oldmeadow, Liz Holliday, Rodney Scott
2014 Gunathilake R, Krishnamurthy V, Oldmeadow C, Kerr E, Padmakumar C, Attia J, et al., 'Relationships between age, other predictive variables, and the 90-day functional outcome after intravenous thrombolysis for acute ischemic stroke', International Journal of Stroke, 9 E36-E37 (2014) [O1]
DOI 10.1111/ijs.12347
Co-authors Chris Levi, Christopher Oldmeadow, Mark Parsons
2014 Squance ML, Reeves GEM, Attia J, 'Patient Reported Frequency of Lupus Flare: Associations with Foundation Makeup and Sunscreen Use', Journal of Cosmetics, Dermatological Sciences and Applications, 4 344-354 (2014) [C1]
DOI 10.4236/jcdsa.2014.45046
2014 Golledge J, Clancy P, Maguire J, Lincz L, Koblar S, Mcevoy M, et al., 'Plasma angiopoietin-1 is lower after ischemic stroke and associated with major disability but not stroke incidence', Stroke, 45 1064-1068 (2014) [C1]

BACKGROUND AND PURPOSE - : Studies in rodent models suggest that upregulating angiopoietin-1 (Angpt1) improves stroke outcomes. The aims of this study were to assess the associati... [more]

BACKGROUND AND PURPOSE - : Studies in rodent models suggest that upregulating angiopoietin-1 (Angpt1) improves stroke outcomes. The aims of this study were to assess the association of plasma Angpt1 with stroke occurrence and outcome. METHODS - : Plasma Angpt1 was measured in 336 patients who had experienced a recent stroke and 321 healthy controls with no stroke history. Patients with stroke (n=285) were reassessed at 3 months and plasma Angpt1 concentration on admission compared between those with severe and minor disability as assessed by the modified Rankin scale. In a separate cohort of 4032 community-acquired older men prospectively followed for a minimum of 6 years, the association of plasma Angpt1 with stroke incidence was examined. RESULTS - : Median plasma Angpt1 was 3-fold lower in patients who had experienced a recent stroke (6.42, interquartile range, 4.26-9.53 compared with 17.36; interquartile range, 14.01-22.46 ng/mL; P<0.001) and remained associated with stroke after adjustment for other risk factors. Plasma Angpt1 concentrations on admission were lower in patients who had severe disability or died at 3 months (median, 5.52; interquartile range, 3.81-8.75 ng/mL for modified Rankin scale 3-6; n=91) compared with those with minor disability (median, 7.04; interquartile range, 4.75-9.92 ng/mL for modified Rankin scale 0-2; n=194), P=0.012, and remained negatively associated with severe disability or death after adjusting for other risk factors. Plasma Angpt1 was not predictive of stroke incidence in community-dwelling older men. CONCLUSIONS - : Plasma Angpt1 concentrations are low after ischemic stroke particularly in patients with poor stroke outcomes at 3 months. Interventions effective at upregulating Angpt1 could potentially improve stroke outcomes. © 2014 American Heart Association, Inc.

DOI 10.1161/STROKEAHA.113.004339
Citations Scopus - 2Web of Science - 1
Co-authors Chris Levi, Lisa Lincz, Mark Mcevoy, Jane Maguire
2014 The Global Burden of Metabolic Risk Factors for Chronic Diseases Collaboration (BMI Mediated Effects), 'Metabolic mediators of the effects of body-mass index, overweight, and obesity on coronary heart disease and stroke: A pooled analysis of 97 prospective cohorts with 1·8 million participants', The Lancet, 383 970-983 (2014) [C1]
DOI 10.1016/S0140-6736(13)61836-X
Citations Scopus - 90
Co-authors Catherine Deste
2014 Gupta SK, Lewis G, Rogers KM, Attia J, Rostron K, O'Neill L, et al., 'Quantitative (99m)Tc DTPA renal transplant scintigraphic parameters: assessment of interobserver agreement and correlation with graft pathologies.', American Journal of Nuclear Medicine and Molecular Imaging, 4 213-224 (2014) [C1]
2014 Dewar DC, White A, Attia J, Tarrant SM, King KL, Balogh ZJ, 'Comparison of postinjury multiple-organ failure scoring systems: Denver versus sequential organ failure assessment', Journal of Trauma and Acute Care Surgery, 77 624-629 (2014) [C1]

Copyright © 2014 by Lippincott Williams & Wilkins. BACKGROUND: The Denver and Sequential Organ Failure Assessment (SOFA) scores have been used widely to describe the epidemiology... [more]

Copyright © 2014 by Lippincott Williams & Wilkins. BACKGROUND: The Denver and Sequential Organ Failure Assessment (SOFA) scores have been used widely to describe the epidemiology of postinjury multiple-organ failure; however, differences in these scores make it difficult to compare incidence, duration, and mortality of multiple-organ failure. The study aim was to compare the performance of the Denver and SOFA scores with respect to the outcomes of mortality, intensive care unit length of stay (ICU LOS), and ventilator days. METHODS: A 60-month prospective epidemiologic study was undertaken at an Australian Level I trauma center. Data were collected on trauma patients that met inclusion criteria (ICU admission, Injury Severity Score [ISS] 9 15, age 9 18 years, head Abbreviated Injury Scale [AIS] score G 3, survival for 948 hours). Demographics, ISS, physiologic parameters, SOFA and Denver scores, and outcome data were prospectively collected. Sensitivity/specificity and receiver operating characteristic curve were calculated for both scores. Analysis was also completed for a Day 3 postinjury SOFA and Denver score. RESULTS: A total of 140 patients met the inclusion criteria (mean [SD] age, 47 [21] years; ISS, 30; male, 69%; mortality rate, 6%; mean [SD] ICU LOS, 9 [7] days; mean [SD] ventilation period, 6 [7] days). There was no difference in the score performance predicting mortality. Day 3 SOFA score of 4 or greater outperformed the Denver score of greater than 3 when predicting ICU LOS and ventilator days (area under the curve, 0.83 vs. 0.69, 0.86 vs. 0.73, respectively). The SOFA score was more sensitive and the Denver score was more specific when predicting mortality, ICU LOS, and ventilator days. CONCLUSION: Both scores had similar performance predicting mortality; however, the Day 3 SOFA score outperforms the Denver score when predicting ICU LOS and ventilator days. Either score could be superior based on whether one is seeking to optimize specificity or sensitivity. It is important to note that these findings are in a non-head-injured population and that there are practical difficulties using the SOFA in head-injured patients. LEVEL OF EVIDENCE: Diagnostic study, level II.

DOI 10.1097/TA.0000000000000406
Citations Scopus - 3Web of Science - 1
Co-authors Zsolt Balogh
2014 Handley TE, Kay-Lambkin FJ, Inder KJ, Lewin TJ, Attia JR, Fuller J, et al., 'Self-reported contacts for mental health problems by rural residents: Predicted service needs, facilitators and barriers', BMC Psychiatry, 14 (2014) [C1]

© 2014 Handley et al.; licensee BioMed Central Ltd. Background: Rural and remote Australians face a range of barriers to mental health care, potentially limiting the extent to wh... [more]

© 2014 Handley et al.; licensee BioMed Central Ltd. Background: Rural and remote Australians face a range of barriers to mental health care, potentially limiting the extent to which current services and support networks may provide assistance. This paper examines self-reported mental health problems and contacts during the last 12¿months, and explores cross-sectional associations between potential facilitators/barriers and professional and non-professional help-seeking, while taking into account expected associations with socio-demographic and health-related factors. Methods: During the 3-year follow-up of the Australian Rural Mental Health Study (ARMHS) a self-report survey was completed by adult rural residents (N = 1,231; 61% female 77% married; 22% remote location; mean age = 59¿years), which examined socio-demographic characteristics, current health status factors, predicted service needs, self-reported professional and non-professional contacts for mental health problems in the last 12¿months, other aspects of help-seeking, and perceived barriers. Results: Professional contacts for mental health problems were reported by 18% of the sample (including 14% reporting General Practitioner contacts), while non-professional contacts were reported by 16% (including 14% reporting discussions with family/friends). Perceived barriers to health care fell under the domains of structural (e.g., costs, distance), attitudinal (e.g., stigma concerns, confidentiality), and time commitments. Participants with 12-month mental health problems who reported their needs as met had the highest levels of service use. Hierarchical logistic regressions revealed a dose-response relationship between the level of predicted need and the likelihood of reporting professional and non-professional contacts, together with associations with socio-demographic characteristics (e.g., gender, relationships, and financial circumstances), suicidal ideation, and attitudinal factors, but not geographical remoteness. Conclusions: Rates of self-reported mental health problems were consistent with baseline findings, including higher rural contact rates with General Practitioners. Structural barriers displayed mixed associations with help-seeking, while attitudinal barriers were consistently associated with lower service contacts. Developing appropriate interventions that address perceptions of mental illness and attitudes towards help-seeking is likely to be vital in optimising treatment access and mental health outcomes in rural areas.

DOI 10.1186/s12888-014-0249-0
Citations Scopus - 2Web of Science - 1
Co-authors Natasha Weaver, Kerry Inder, Brian Kelly, Terry Lewin
2014 Wang G, Murphy VE, Namazy J, Powell H, Schatz M, Chambers C, et al., 'The risk of maternal and placental complications in pregnant women with asthma: A systematic review and meta-analysis', Journal of Maternal-Fetal and Neonatal Medicine, 27 934-942 (2014) [C1]

Objective: To investigate if maternal asthma is associated with an increased risk of maternal and placental complications in pregnancy. Methods: Electronic databases were searched... [more]

Objective: To investigate if maternal asthma is associated with an increased risk of maternal and placental complications in pregnancy. Methods: Electronic databases were searched for the following terms: (asthma or wheeze) and (pregnan* or perinat* or obstet*). Cohort studies published between January 1975 and March 2012 were considered for inclusion. Forty publications met the inclusion criteria, reporting at least one maternal or placental complication in pregnant women with and without asthma. Relative risk (RR) with 95% confidence intervals (CIs) was calculated. Results: Maternal asthma was associated with a significantly increased risk of cesarean section (RR=1.31, 95%CI=[1.22-1.39]), gestational diabetes (RR=1.39, 95%CI=[1.17-1.66]), hemorrhage (antepartum: RR=1.25, 95%CI=[1.10-1.42]; postpartum: RR=1.29, 95%CI=[1.18-1.41]), placenta previa (RR=1.23, 95%CI=[1.07-1.40]), placental abruption (RR=1.29, 95%CI=[1.14-1.47]) and premature rupture of membranes (RR=1.21, 95%CI=1.07-1.37). Moderate to severe asthma significantly increased the risk of cesarean section (RR=1.19, 95%CI=[1.09-1.31]) and gestational diabetes (RR=1.19, 95%CI=[1.06-1.33]) compared to mild asthma. Bronchodilator use was associated with a significantly lowered risk of gestational diabetes (RR=0.64, 95%CI=[0.57-0.72]). Conclusions: Pregnant women with asthma are at increased risk of maternal and placental complications, and women with moderate/severe asthma may be at particular risk. Further studies are required to elucidate whether adequate control of asthma during pregnancy reduces these risks. © 2014 Informa UK Ltd. All rights reserved.

DOI 10.3109/14767058.2013.847080
Citations Scopus - 9Web of Science - 4
Co-authors Vanessa Murphy, Peter Gibson
2014 Napthali K, Boyle M, Tran H, Schofield PW, Peel R, McEvoy M, et al., 'Thyroid antibodies, autoimmunity and cognitive decline: is there a population-based link?', Dement Geriatr Cogn Dis Extra, 4 140-146 (2014) [C1]
DOI 10.1159/000362716
Co-authors Christopher Oldmeadow, Roseanne Peel, Mark Mcevoy, Peter Schofield
2014 Jackel D, Attia J, Pickles R, 'General medicine advanced training: lessons from the John Hunter training programme.', Intern Med J, 44 302-306 (2014) [C2]
DOI 10.1111/imj.12357
2013 Johnson NA, Kypri K, Saunders JB, Saitz R, Attia J, Dunlop A, et al., 'The hospital outpatient alcohol project (HOAP): protocol for an individually randomized, parallel-group superiority trial of electronic alcohol screening and brief intervention versus screening alone for unhealthy alcohol use.', Addict Sci Clin Pract, 8 14 (2013) [C3]
DOI 10.1186/1940-0640-8-14
Citations Scopus - 3
Co-authors Kypros Kypri, Luke Wolfenden, Natalie Johnson, Adrian Dunlop
2013 Handley TE, Attia JR, Inder KJ, Kay-Lambkin FJ, Barker D, Lewin TJ, Kelly BJ, 'Longitudinal course and predictors of suicidal ideation in a rural community sample.', Australian & New Zealand Journal of Psychiatry, 47 1032-1040 (2013) [C1]
DOI 10.1177/0004867413495318
Citations Scopus - 5Web of Science - 1
Co-authors Brian Kelly, Terry Lewin, Kerry Inder
2013 Vashum KP, McEvoy M, Shi Z, Milton AH, Islam MR, Sibbritt D, et al., 'Is dietary zinc protective for type 2 diabetes? Results from the Australian longitudinal study on women's health', BMC Endocrine Disorders, 13 (2013) [C1]
DOI 10.1186/1472-6823-13-40
Citations Scopus - 4Web of Science - 3
Co-authors Julie Byles, Milton Hasnat, Amanda Patterson, Deborah Loxton, Mark Mcevoy
2013 Walsh B, Slater S, Nair B, Attia J, 'The relationship between the apolipoprotein E e4 allele and hippocampal MRI volume in community dwelling individuals with mild Alzheimer's disease', Degenerative Neurological and Neuromuscular Disease, 3 11-14 (2013) [C1]
DOI 10.2147/DNND.S40835
2013 Johnson NA, Kypri K, Attia J, 'Development of an electronic alcohol screening and brief intervention program for hospital outpatients with unhealthy alcohol use.', JMIR Res Protoc, 2 e36 (2013) [C1]
DOI 10.2196/resprot.2697
Citations Scopus - 1
Co-authors Natalie Johnson, Kypros Kypri
2013 Gunathilake R, Oldmeadow C, McEvoy M, Kelly B, Inder K, Schofield P, Attia J, 'Mild Hyponatremia Is Associated With Impaired Cognition And Falls In Community-Dwelling Older Persons', Journal of the American Geriatrics Society, 61 1838-1839 (2013) [C1]
DOI 10.1111/jgs.12468
Citations Scopus - 13Web of Science - 10
Co-authors Christopher Oldmeadow, Brian Kelly, Mark Mcevoy, Kerry Inder, Peter Schofield
2013 Thakkinstian A, McKay GJ, Silvestri J, Chakravarthy U, Attia J, 'FIVE AUTHORS REPLY', AMERICAN JOURNAL OF EPIDEMIOLOGY, 177 1024-1025 (2013) [C3]
DOI 10.1093/aje/kwt068
2013 Köttgen A, Albrecht E, Teumer A, Vitart V, Krumsiek J, Hundertmark C, et al., 'Genome-wide association analyses identify 18 new loci associated with serum urate concentrations', Nature Genetics, 45 145-154 (2013)

Elevated serum urate concentrations can cause gout, a prevalent and painful inflammatory arthritis. By combining data from >140,000 individuals of European ancestry within the Glo... [more]

Elevated serum urate concentrations can cause gout, a prevalent and painful inflammatory arthritis. By combining data from >140,000 individuals of European ancestry within the Global Urate Genetics Consortium (GUGC), we identified and replicated 28 genome-wide significant loci in association with serum urate concentrations (18 new regions in or near TRIM46, INHBB, SFMBT1, TMEM171, VEGFA, BAZ1B, PRKAG2, STC1, HNF4G, A1CF, ATXN2, UBE2Q2, IGF1R, NFAT5, MAF, HLF, ACVR1B-ACVRL1 and B3GNT4). Associations for many of the loci were of similar magnitude in individuals of non-European ancestry. We further characterized these loci for associations with gout, transcript expression and the fractional excretion of urate. Network analyses implicate the inhibins-activins signaling pathways and glucose metabolism in systemic urate control. New candidate genes for serum urate concentration highlight the importance of metabolic control of urate production and excretion, which may have implications for the treatment and prevention of gout. © 2013 Nature America, Inc. All rights reserved.

DOI 10.1038/ng.2500
Co-authors Liz Holliday, Rodney Scott, Christopher Oldmeadow
2013 Attia JR, Pearce R, 'The use, misuse and abuse of dabigatran', MEDICAL JOURNAL OF AUSTRALIA, 198 356-357 (2013) [C3]
DOI 10.5694/mja12.10729
Citations Scopus - 6Web of Science - 5
2013 Yadav S, Cotlarciuc I, Munroe PB, Khan MS, Nalls MA, Bevan S, et al., 'Genome-Wide Analysis of Blood Pressure Variability and Ischemic Stroke', Stroke, 44 2703-2709 (2013) [C1]
DOI 10.1161/STROKEAHA.113.002186
Citations Scopus - 4Web of Science - 4
Co-authors Liz Holliday, Jane Maguire, Rodney Scott, Mark Mcevoy
2013 Buitendijk GHS, Rochtchina E, Myers C, Van Duijn CM, Lee KE, Klein BEK, et al., 'Prediction of age-related macular degeneration in the general population: The three continent AMD consortium', Ophthalmology, 120 2644-2655 (2013) [C1]
DOI 10.1016/j.ophtha.2013.07.053
Citations Scopus - 23Web of Science - 16
Co-authors Liz Holliday
2013 Schache M, Richardson AJ, Mitchell P, Wang JJ, Rochtchina E, Viswanathan AC, et al., 'Genetic association of refractive error and axial length with 15q14 but not 15q25 in the Blue Mountains Eye Study Cohort', Ophthalmology, 120 292-297 (2013) [C1]
Citations Scopus - 9Web of Science - 5
Co-authors Liz Holliday, Rodney Scott
2013 Handley TE, Kay-Lambkin FJ, Baker AL, Lewin TJ, Kelly BJ, Inder KJ, et al., 'Incidental treatment effects of CBT on suicidal ideation and hopelessness', JOURNAL OF AFFECTIVE DISORDERS, 151 275-283 (2013) [C1]
DOI 10.1016/j.jad.2013.06.005
Citations Scopus - 1Web of Science - 1
Co-authors Brian Kelly, Terry Lewin, Amanda Baker, Kerry Inder
2013 McEvoy MA, Schofield P, Smith W, Agho K, Mangoni AA, Soiza RL, et al., 'Serum methylarginines and incident depression in a cohort of older adults', Journal of Affective Disorders, 151 493-499 (2013) [C1]
DOI 10.1016/j.jad.2013.06.033
Citations Scopus - 5Web of Science - 4
Co-authors Peter Schofield, Kerry Inder, Brian Kelly, Roseanne Peel, Mark Mcevoy, Wayne Smith
2013 Williams FMK, Carter AM, Hysi PG, Surdulescu G, Hodgkiss D, Soranzo N, et al., 'Ischemic stroke is associated with the ABO locus: The EuroCLOT Study', Annals of Neurology, 73 16-31 (2013) [C1]
Citations Scopus - 31Web of Science - 24
Co-authors Chris Levi, Liz Holliday, Rodney Scott
2013 Minelli C, De Grandi A, Weichenberger CX, Goegele M, Modenese M, Attia J, et al., 'Importance of Different Types of Prior Knowledge in Selecting Genome-Wide Findings for Follow-Up', GENETIC EPIDEMIOLOGY, 37 205-213 (2013) [C1]
DOI 10.1002/gepi.21705
Citations Scopus - 5Web of Science - 2
2013 Thompson JR, Goegele M, Weichenberger CX, Modenese M, Attia J, Barrett JH, et al., 'SNP Prioritization Using a Bayesian Probability of Association', GENETIC EPIDEMIOLOGY, 37 214-221 (2013) [C1]
DOI 10.1002/gepi.21704
Citations Scopus - 3
2013 Kongtharvonskul J, Attia J, Thamakaison S, Kijkunasathian C, Woratanarat P, Thakkinstian A, 'Clinical outcomes of double- vs single-bundle anterior cruciate ligament reconstruction: A systematic review of randomized control trials', SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS, 23 1-14 (2013) [C1]
DOI 10.1111/j.1600-0838.2011.01439.x
Citations Scopus - 7Web of Science - 7
2013 Greenop KR, Peters S, Bailey HD, Fritschi L, Attia J, Scott RJ, et al., 'Exposure to pesticides and the risk of childhood brain tumors', CANCER CAUSES & CONTROL, 24 1269-1278 (2013) [C1]
DOI 10.1007/s10552-013-0205-1
Citations Scopus - 9Web of Science - 7
Co-authors Rodney Scott
2013 Rattanasiri S, McDaniel DO, McEvoy M, Anothaisintawee T, Sobhonslidsuk A, Attia J, Thakkinstian A, 'The association between cytokine gene polymorphisms and graft rejection in liver transplantation: A systematic review and meta-analysis', TRANSPLANT IMMUNOLOGY, 28 62-70 (2013) [C1]
DOI 10.1016/j.trim.2012.10.003
Citations Scopus - 3Web of Science - 1
Co-authors Mark Mcevoy
2013 Kottgen A, Albrecht E, Teumer A, Vitart V, Krumsiek J, Hundertmark C, et al., 'Genome-wide association analyses identify 18 new loci associated with serum urate concentrations', Nature Genetics, 45 145-154 (2013) [C1]
Citations Scopus - 121Web of Science - 85
Co-authors Rodney Scott, Christopher Oldmeadow, Liz Holliday
2013 Rietveld CA, Medland SE, Derringer J, Yang J, Esko T, Martin NW, et al., 'GWAS of 126,559 individuals identifies genetic variants associated with educational attainment', Science, 340 1467-1471 (2013) [C1]
Citations Scopus - 127Web of Science - 87
Co-authors Christopher Oldmeadow, Liz Holliday, Rodney Scott
2013 Magee CA, Holliday EG, Attia JR, Kritharides L, Banks E, 'Investigation of the relationship between sleep duration, all-cause mortality, and preexisting disease', Sleep Medicine, 14 591-596 (2013) [C1]
Citations Scopus - 13Web of Science - 7
Co-authors Liz Holliday
2013 Hunt JJ, Lumsdaine W, Attia J, Balogh ZJ, 'AO type-C distal radius fractures: the influence of computed tomography on surgeon's decision-making', ANZ JOURNAL OF SURGERY, 83 676-678 (2013) [C3]
DOI 10.1111/j.1445-2197.2012.06311.x
Citations Scopus - 1Web of Science - 1
Co-authors Zsolt Balogh
2013 Stambolian D, Wojciechowski R, Oexle K, Pirastu M, Li X, Raffel LJ, et al., 'Meta-analysis of genome-wide association studies in five cohorts reveals common variants in RBFOX1, a regulator of tissue-specific splicing, associated with refractive error', Human Molecular Genetics, 22 2754-2764 (2013) [C1]
Citations Scopus - 16Web of Science - 14
Co-authors Rodney Scott, Liz Holliday
2013 Ranasinghe WKB, Attia J, Oldmeadow C, Lawrentschuk N, Robertson J, Ranasinghe T, et al., 'Bladder carcinoma in situ (CIS) in Australia: a rising incidence for an under-reported malignancy', BJU International, 112 46-52 (2013) [C1]
DOI 10.1111/bju.12052
Citations Scopus - 2Web of Science - 2
Co-authors Christopher Oldmeadow
2013 Holliday S, Magin P, Oldmeadow C, Attia J, Dunbabin J, Henry J, et al., 'An examination of the influences on New South Wales general practitioners regarding the provision of opioid substitution therapy', Drug and Alcohol Review, 32 495-503 (2013) [C1]
DOI 10.1111/dar.12046
Citations Scopus - 5Web of Science - 3
Co-authors Parker Magin, Christopher Oldmeadow, Adrian Dunlop
2013 Allen J, Inder KJ, Lewin TJ, Attia JR, Kay-Lambkin FJ, Baker AL, et al., 'Integrating and extending cohort studies: lessons from the eXtending Treatments, Education and Networks in Depression (xTEND) study', BMC Medical Research Methodology, 13 (2013) [C1]
DOI 10.1186/1471-2288-13-122
Citations Scopus - 3Web of Science - 2
Co-authors Amanda Baker, Brian Kelly, Kerry Inder, Terry Lewin
2013 Gupta K, Dhawan A, Abel C, Talley N, Attia J, 'A re-evaluation of the scratch test for locating the liver edge', BMC GASTROENTEROLOGY, 13 (2013) [C1]
DOI 10.1186/1471-230X-13-35
Citations Scopus - 3Web of Science - 1
Co-authors Nicholas Talley
2013 Vejakama P, Thakkinstian A, Ingsathit A, Dhanakijcharoen P, Attia J, 'Prognostic factors of all-cause mortalities in continuous ambulatory peritoneal dialysis: a cohort study', BMC NEPHROLOGY, 14 (2013) [C1]
DOI 10.1186/1471-2369-14-28
Citations Scopus - 3Web of Science - 1
2013 Courtney RJ, Paul CL, Sanson-Fisher RW, Macrae FA, Carey ML, Attia J, McEvoy M, 'Individual- and provider-level factors associated with colorectal cancer screening in accordance with guideline recommendation: a community-level perspective across varying levels of risk', BMC PUBLIC HEALTH, 13 (2013) [C1]
DOI 10.1186/1471-2458-13-248
Citations Scopus - 6Web of Science - 1
Co-authors Mariko Carey, Chris Paul, Rob Sanson-Fisher, Mark Mcevoy
2013 Robertson J, McElduff P, Pearson S-A, Henry DA, Inder KJ, Attia JR, 'The health services burden of heart failure: an analysis using linked population health data-sets (vol 12, pg 103, 2012)', BMC HEALTH SERVICES RESEARCH, 13 (2013) [O1]
DOI 10.1186/1472-6963-13-179
Co-authors Kerry Inder, Mddah01
2013 Allen J, Inder KJ, Lewin TJ, Attia JR, Kelly BJ, 'Construct validity of the Assessment of Quality of Life - 6D (AQoL-6D) in community samples', HEALTH AND QUALITY OF LIFE OUTCOMES, 11 (2013) [C1]
DOI 10.1186/1477-7525-11-61
Citations Scopus - 8Web of Science - 6
Co-authors Kerry Inder, Brian Kelly, Terry Lewin
2013 Allen J, Inder KJ, Harris ML, Lewin TJ, Attia JR, Kelly BJ, 'Quality of life impact of cardiovascular and affective conditions among older residents from urban and rural communities', HEALTH AND QUALITY OF LIFE OUTCOMES, 11 (2013) [C1]
DOI 10.1186/1477-7525-11-140
Citations Scopus - 2Web of Science - 2
Co-authors Brian Kelly, Melissa Harris, Kerry Inder, Terry Lewin
2013 Mangoni AA, Zinellu A, Carru C, Attia JR, McEvoy M, 'Serum thiols and cardiovascular risk scores: a combined assessment of transsulfuration pathway components and substrate/product ratios', JOURNAL OF TRANSLATIONAL MEDICINE, 11 (2013) [C1]
DOI 10.1186/1479-5876-11-99
Citations Scopus - 6Web of Science - 5
Co-authors Mark Mcevoy
2013 Holliday S, Magin P, Dunbabin J, Oldmeadow C, Henry J-M, Lintzeris N, et al., 'An Evaluation of the Prescription of Opioids for Chronic Nonmalignant Pain by Australian General Practitioners', PAIN MEDICINE, 14 62-74 (2013) [C1]
DOI 10.1111/j.1526-4637.2012.01527.x
Citations Scopus - 9Web of Science - 6
Co-authors Adrian Dunlop, Christopher Oldmeadow, Parker Magin
2013 Numthavaj P, Tanjararak K, Roongpuvapaht B, McEvoy M, Attia J, Thakkinstian A, 'Efficacy of Mitomycin C for postoperative endoscopic sinus surgery: a systematic review and meta-analysis', CLINICAL OTOLARYNGOLOGY, 38 198-207 (2013) [C1]
DOI 10.1111/coa.12114
Citations Scopus - 2Web of Science - 3
Co-authors Mark Mcevoy
2013 Talseth-Palmer B, Holliday EG, Evans T-J, McEvoy MA, Attia JR, Grice DM, et al., 'Continuing difficulties in interpreting CNV data: Lessons from a genome-wide CNV association study of Australian HNPCC/lynch syndrome patients', BMC Medical Genomics, 6 1-13 (2013) [C1]
Citations Scopus - 7Web of Science - 4
Co-authors Rodney Scott, Mark Mcevoy, Bente Talseth-Palmer, Liz Holliday
2013 Williams N, Hardy BM, Tarrant S, Enninghorst N, Attia J, Oldmeadow C, Balogh ZJ, 'Changes in hip fracture incidence, mortality and length of stay over the last decade in an Australian major trauma centre.', Archives of Osteoporosis, 8 (2013) [C1]
DOI 10.1007/s11657-013-0150-3
Citations Scopus - 14
Co-authors Zsolt Balogh, Christopher Oldmeadow
2013 Holliday EG, Magee CA, Kritharides L, Banks E, Attia J, 'Short Sleep Duration Is Associated with Risk of Future Diabetes but Not Cardiovascular Disease: a Prospective Study and Meta-Analysis', PLOS ONE, 8 (2013) [C1]
DOI 10.1371/journal.pone.0082305
Citations Scopus - 24Web of Science - 13
Co-authors Liz Holliday
2013 Mangoni AA, Zinellu A, Carru C, Attia JR, McEvoy M, 'Transsulfuration Pathway Thiols and Methylated Arginines: The Hunter Community Study', PLOS ONE, 8 (2013) [C1]
DOI 10.1371/journal.pone.0054870
Citations Scopus - 2Web of Science - 2
Co-authors Mark Mcevoy
2013 Islam MR, Arslan I, Attia J, McEvoy M, McElduff P, Basher A, et al., 'Is Serum Zinc Level Associated with Prediabetes and Diabetes?: A Cross-Sectional Study from Bangladesh', PLOS ONE, 8 (2013) [C1]
DOI 10.1371/journal.pone.0061776
Citations Scopus - 10Web of Science - 5
Co-authors Mark Mcevoy, Roseanne Peel, Milton Hasnat
2013 McEvoy MA, Schofield PW, Smith WT, Agho K, Mangoni AA, Soiza RL, et al., 'Serum Methylarginines and Spirometry-Measured Lung Function in Older Adults', PLOS ONE, 8 (2013) [C1]
DOI 10.1371/journal.pone.0058390
Co-authors Peter Schofield, Mark Mcevoy, Roseanne Peel, Wayne Smith
2013 Sun C, Young TL, Mackey DA, Van Zuydam NR, Doney ASF, Palmer CNA, et al., 'Genetic loci for retinal arteriolar microcirculation', PLoS One, 8 e65804 (2013) [C1]
Citations Scopus - 3Web of Science - 2
Co-authors Rodney Scott, Liz Holliday
2013 Jensen RA, Sim X, Li X, Cotch MF, Ikram MK, Holliday EG, et al., 'Genome-wide association study of retinopathy in individuals without diabetes', PLoS One, 8 e54232 (2013) [C1]
Citations Scopus - 5Web of Science - 5
Co-authors Liz Holliday, Rodney Scott
2013 Holliday EG, Smith AV, Cornes BK, Buitendijk GHS, Jensen RA, Sim X, et al., 'Insights into the genetic architecture of early stage age-related macular degeneration: A genome-wide association study meta-analysis', PLoS One, 8 e53830 (2013) [C1]
Citations Scopus - 39Web of Science - 30
Co-authors Rodney Scott, Liz Holliday
2013 Sukrat B, Wilasrusmee C, Siribumrungwong B, McEvoy M, Okascharoen C, Attia J, Thakkinstian A, 'Hemoglobin Concentration and Pregnancy Outcomes: A Systematic Review and Meta-Analysis', BIOMED RESEARCH INTERNATIONAL, 1-9 (2013) [C1]
DOI 10.1155/2013/769057
Citations Scopus - 3Web of Science - 1
Co-authors Mark Mcevoy
2012 Milne E, Greenop KR, Scott R, Bailey HD, Attia JR, Dalla-Pozza L, et al., 'Parental prenatal smoking and risk of childhood acute lymphoblastic leukemia', American Journal of Epidemiology, 175 43-53 (2012) [C1]
Citations Scopus - 35Web of Science - 26
Co-authors Rodney Scott
2012 Gogele M, Minelli C, Thakkinstian A, Yurkiewich A, Pattaro C, Pramstaller PP, et al., 'Methods for meta-analyses of genome-wide association studies: Critical assessment of empirical evidence', American Journal of Epidemiology, 175 739-749 (2012) [C1]
Citations Scopus - 26Web of Science - 21
2012 Thakkinstian A, McEvoy MA, Chakravarthy U, Chakrabarti S, McKay GJ, Ryu E, et al., 'The association between complement component 2/complement factor B polymorphisms and age-related macular degeneration: A HuGE review and meta-analysis', American Journal of Epidemiology, 176 361-372 (2012) [C1]
Citations Scopus - 29Web of Science - 23
Co-authors Mark Mcevoy
2012 Wilasrusmee C, Sukrat B, McEvoy MA, Attia JR, Thakkinstian A, 'Systematic review and meta-analysis of safety of laparoscopic versus open appendicectomy for suspected appendicitis in pregnancy', British Journal of Surgery, 99 1470-1478 (2012) [C1]
Citations Scopus - 22Web of Science - 17
Co-authors Mark Mcevoy
2012 Vejakama P, Thakkinstian A, Attia JR, 'Renoprotective effects of renin-angiotensin-aldosterone system blockers in type 2 diabetes: Demystifying multiple treatment comparisons in a network meta-analysis. Reply', Diabetologia, 55 2549-2550 (2012) [C3]
2012 Vejakama P, Thakkinstian A, Lertrattananon D, Ingsathit A, Ngarmukos C, Attia JR, 'Reno-protective effects of renin-angiotensin system blockade in type 2 diabetic patients: A systematic review and network meta-analysis', Diabetologia, 55 566-578 (2012) [C1]
Citations Scopus - 41Web of Science - 32
2012 Courtney RJ, Paul CL, Sanson-Fisher RW, Macrae FA, Carey ML, Attia JR, McEvoy MA, 'Colorectal cancer screening in Australia: A community-level perspective', Medical Journal of Australia, 196 516-520 (2012) [C1]
Citations Scopus - 9Web of Science - 8
Co-authors Rob Sanson-Fisher, Mark Mcevoy, Chris Paul, Mariko Carey
2012 Murphy VE, Namazy JA, Powell H, Schatz M, Chambers C, Attia J, Gibson PG, 'A Meta-Analysis of Adverse Perinatal Outcomes in Women With Asthma EDITORIAL COMMENT', OBSTETRICAL & GYNECOLOGICAL SURVEY, 67 77-78 (2012) [C3]
DOI 10.1097/OGX.0b013e318247c54d
Co-authors Peter Gibson
2012 Hiles SA, Baker AL, De Malmanche T, Attia JR, 'Interleukin-6, C-reactive protein and interleukin-10 after antidepressant treatment in people with depression: A meta-analysis', Psychological Medicine, 42 2015-2026 (2012) [C1]
DOI 10.1017/S0033291712000128
Citations Scopus - 33Web of Science - 29
Co-authors Amanda Baker
2012 Cheng YC, Anderson CD, Bione S, Keene K, Maguire JM, Nalls M, et al., 'Are myocardial infarction-associated single-nucleotide polymorphisms associated with ischemic stroke?', Stroke, 43 980-U143 (2012) [C1]
Citations Scopus - 13Web of Science - 12
Co-authors Jane Maguire, Rodney Scott, Lisa Lincz, Liz Holliday, Pablo Moscato, Chris Levi
2012 Gupta SK, Lewis G, Rogers K, Attia JR, 'Quantitative Tc-99m DTPA renal transplant scintigraphy predicts graft survival in the very early postoperative period', Nuclear Medicine Communications, 33 1292-1299 (2012) [C1]
Citations Scopus - 4Web of Science - 3
2012 Suthers BG, Pickles RW, Boyle MJ, Nair BR, Cook J, Attia JR, 'The effect of context on performance of an acute medical unit: Experience from an Australian tertiary hospital', Australian Health Review, 36 320-324 (2012) [C1]
Citations Scopus - 1Web of Science - 2
2012 Bailey HD, Miller M, Langridge A, De Klerk NH, Van Bockxmeer FM, Attia JR, et al., 'Maternal dietary intake of folate and vitamins B6 and B12 during pregnancy and the risk of childhood acute lymphoblastic leukemia', Nutrition and Cancer, 64 1122-1130 (2012) [C1]
DOI 10.1080/01635581.2012.707278
Citations Scopus - 9Web of Science - 4
Co-authors Rodney Scott
2012 Suthers B, Hansbro PM, Thambar S, McEvoy MA, Peel R, Attia JR, 'Pneumococcal vaccination may induce anti-oxidized low-density lipoprotein antibodies that have potentially protective effects against cardiovascular disease', Vaccine, 30 3983-3985 (2012) [C1]
Citations Scopus - 6Web of Science - 5
Co-authors Roseanne Peel, Philip Hansbro, Mark Mcevoy
2012 Guest M, Boggess MM, Attia JR, 'Relative risk of elevated hearing threshold compared to ISO1999 normative populations for Royal Australian Air Force male personnel', Hearing Research, 285 65-76 (2012) [C1]
Citations Scopus - 2Web of Science - 2
Co-authors Catherine Deste
2012 Hiles SA, Baker AL, De Malmanche T, Attia JR, 'A meta-analysis of differences in IL-6 and IL-10 between people with and without depression: Exploring the causes of heterogeneity', Brain, Behavior, and Immunity, 26 1180-1188 (2012) [C1]
Citations Scopus - 54Web of Science - 45
Co-authors Amanda Baker
2012 Woratanarat P, Angsanuntsukh C, Rattanasiri S, Attia JR, Woratanarat T, Thakkinstian A, 'Meta-analysis of pinning in supracondylar fracture of the humerus in children', Journal of Orthopaedic Trauma, 26 48-53 (2012) [C1]
Citations Scopus - 17Web of Science - 11
2012 Reid MG, Parkinson L, Gibson RE, Schofield PW, D'Este CA, Attia JR, et al., 'Memory Complaint Questionnaire performed poorly as screening tool: Validation against psychometric tests and affective measures', Journal of Clinical Epidemiology, 65 199-205 (2012) [C1]
Citations Scopus - 13Web of Science - 10
Co-authors Julie Byles, Catherine Deste, Meredith Tavener, Peter Schofield, L Parkinson
2012 Handley T, Inder KJ, Kelly BJ, Attia JR, Lewin TJ, Fitzgerald MN, Kay-Lambkin FJ, 'You've got to have friends: The predictive value of social integration and support in suicidal ideation among rural communities', Social Psychiatry and Psychiatric Epidemiology, 47 1281-1290 (2012) [C1]
Citations Scopus - 11Web of Science - 11
Co-authors Terry Lewin, Brian Kelly, Kerry Inder
2012 Magee CA, Kritharides L, Attia JR, McElduff P, Banks E, 'Short and long sleep duration are associated with prevalent cardiovascular disease in Australian adults', Journal of Sleep Research, 21 441-447 (2012) [C1]
Citations Scopus - 27Web of Science - 20
2012 White JH, Gray KR, Magin PJ, Attia JR, Sturm J, Carter G, Pollack M, 'Exploring the experience of post-stroke fatigue in community dwelling stroke survivors: A prospective qualitative study', Disability and Rehabilitation, 34 1376-1384 (2012) [C1]
Citations Scopus - 17Web of Science - 10
Co-authors Parker Magin, Gregory Carter
2012 White JH, Miller B, Magin PJ, Attia JR, Sturm J, Pollack M, 'Access and participation in the community: A prospective qualitative study of driving post-stroke', Disability and Rehabilitation, 34 831-838 (2012) [C1]
Citations Scopus - 14Web of Science - 11
Co-authors Parker Magin
2012 Collins NJ, Hatton R, Ng K, Bhagwandeen R, Attia JR, Oldmeadow CJ, Jayasinghe R, 'Percutaneous device closure of patent foramen ovale using the premere occlusion device: Initial experience, procedural, and intermediate-term results', Journal of Invasive Cardiology, 24 164-168 (2012) [C1]
Citations Scopus - 2Web of Science - 1
Co-authors Christopher Oldmeadow
2012 Bellenguez C, Bevan S, Gschwendtner A, Spencer CCA, Burgess AI, Pirinen M, et al., 'Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke', Nature Genetics, 44 328-333 (2012) [C1]
DOI 10.1038/ng.1081
Citations Scopus - 146Web of Science - 105
Co-authors Chris Levi, Liz Holliday
2012 Nyholt DR, Low S-K, Anderson CA, Painter JN, Uno S, Morris AP, et al., 'Genome-wide association meta-analysis identifies new endometriosis risk loci', Nature Genetics, 44 1355-1359 (2012) [C1]
Citations Scopus - 77Web of Science - 54
Co-authors Rodney Scott, Liz Holliday, Mark Mcevoy
2012 Holliday EG, Maguire JM, Evans T-J, Koblar SA, Jannes J, Sturm J, et al., 'Common variants at 6p21.1 are associated with large artery atherosclerotic stroke', Nature Genetics, 44 1147-1153 (2012) [C1]
Citations Scopus - 63Web of Science - 54
Co-authors Mark Mcevoy, Jane Maguire, Rodney Scott, Lisa Lincz, Pablo Moscato, Chris Levi, Liz Holliday, Christopher Oldmeadow, Wayne Smith, Roseanne Peel, Mark Parsons
2012 Okada Y, Sim X, Go MJ, Wu J-Y, Gu D, Takeuchi F, et al., 'Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations', Nature Genetics, 44 904-909 (2012) [C1]
Citations Scopus - 58Web of Science - 46
Co-authors Rodney Scott, Christopher Oldmeadow, Liz Holliday
2012 Siribumrungwong B, Noorit P, Wilasrusmee C, Attia JR, Thakkinstian A, 'A systematic review and meta-analysis of randomised controlled trials comparing endovenous ablation and surgical intervention in patients with varicose vein', European Journal of Vascular and Endovascular Surgery, 44 214-233 (2012) [C1]
Citations Scopus - 48Web of Science - 21
2012 Lechner-Scott J, Spencer B, De Malmanche T, Attia JR, Fitzgerald M, Trojano M, et al., 'The frequency of CSF oligoclonal banding in multiple sclerosis increases with latitude', Multiple Sclerosis Journal, 18 974-982 (2012) [C1]
Citations Scopus - 23Web of Science - 17
2012 Jackson N, Barlow M, Leitch J, Attia JR, 'Treating atrial fibrillation: Pulmonary vein isolation with the cryoballoon technique', Heart Lung and Circulation, 21 427-432 (2012) [C1]
Citations Scopus - 10Web of Science - 5
2012 Hiew C, Duggan A, De Malmanche T, Hatton R, Baker FA, Attia JR, Collins N, 'Prevalence of Helicobacter pylori positivity in patients undergoing percutaneous coronary intervention', Internal Medicine Journal, 42 289-293 (2012) [C1]
Citations Scopus - 2Web of Science - 2
2012 Courtney RJ, Paul CL, Sanson-Fisher RW, Macrae F, Attia JR, McEvoy MA, 'Current state of medical-advice-seeking behaviour for symptoms of colorectal cancer: determinants of failure and delay in medical consultation', Colorectal Disease, 14 e222-e229 (2012) [C1]
Citations Scopus - 11Web of Science - 5
Co-authors Chris Paul, Mark Mcevoy, Rob Sanson-Fisher
2012 Thakkinstian A, Attia JR, Anothaisintawee T, Nickel JC, 'a-blockers, antibiotics and anti-inflammatories have a role in the management of chronic prostatitis/chronic pelvic pain syndrome', BJU International, 110 1014-1022 (2012) [C1]
Citations Scopus - 23Web of Science - 14
2012 Murphy VE, Namazy JA, Powell H, Schatz M, Chambers C, Attia JR, Gibson PG, 'Severity of asthma in pregnancy affects perinatal outcomes - Authors' Reply', BJOG - An International Journal of Obstetrics and Gynaecology, 119 508-509 (2012) [C3]
DOI 10.1111/j.1471-0528.2011.03258.x
Citations Scopus - 1
Co-authors Vanessa Murphy, Peter Gibson
2012 Courtney RJ, Paul CL, Sanson-Fisher RW, Macrae FA, Carey ML, Attia JR, McEvoy MA, 'Colorectal cancer risk assessment and screening recommendation: A community survey of healthcare providers' practice from a patient perspective', BMC Family Practice, 13 1-9 (2012) [C1]
Citations Scopus - 2Web of Science - 2
Co-authors Mark Mcevoy, Chris Paul, Rob Sanson-Fisher, Mariko Carey
2012 Courtney RJ, Paul CL, Sanson-Fisher RW, Macrae FA, Attia JR, McEvoy MA, 'Factors associated with consultation behaviour for primary symptoms potentially indicating colorectal cancer: A cross-sectional study on response to symptoms', BMC Gastroenterology, 12 1-9 (2012) [C1]
Citations Scopus - 8Web of Science - 5
Co-authors Chris Paul, Mark Mcevoy, Rob Sanson-Fisher
2012 Gwynn JD, Flood VM, D'Este CA, Attia JR, Turner N, Cochrane J, et al., 'Poor food and nutrient intake among Indigenous and non-Indigenous rural Australian children', BMC Pediatrics, 12 1-14 (2012) [C1]
Citations Scopus - 9Web of Science - 7
Co-authors John Wiggers, Catherine Deste, Josephine Gwynn
2012 Handley T, Inder KJ, Kay-Lambkin FJ, Stain HJ, Fitzgerald M, Lewin TJ, et al., 'Contributors to suicidality in rural communities: Beyond the effects of depression', BMC Psychiatry, 12 105 (2012) [C1]
Citations Scopus - 11Web of Science - 6
Co-authors Brian Kelly, Helen Stain, Kerry Inder, Terry Lewin
2012 Allen J, Inder KJ, Lewin TJ, Attia JR, Kelly BJ, 'Social support and age influence distress outcomes differentially across urban, regional and remote Australia: An exploratory study', BMC Public Health, 12 928 (2012) [C1]
Citations Scopus - 11Web of Science - 6
Co-authors Terry Lewin, Brian Kelly, Kerry Inder
2012 Thomas L, Rivett DA, Attia JR, Levi CR, 'Risk factors and clinical presentation of craniocervical arterial dissection: A prospective study', BMC Musculoskeletal Disorders, 13 1-6 (2012) [C3]
Co-authors Darren Rivett, Chris Levi, Lucy Thomas
2012 Robertson J, McElduff P, Pearson S-A, Henry DA, Inder KJ, Attia JR, 'The health services burden of heart failure: An analysis using linked population health data-sets', BMC Health Services Research, 12 1-11 (2012) [C1]
Citations Scopus - 13Web of Science - 13
Co-authors Kerry Inder
2012 Islam MR, Khan I, Hassan SMN, McEvoy MA, D'Este CA, Attia JR, et al., 'Association between type 2 diabetes and chronic arsenic exposure in drinking water: A cross sectional study in Bangladesh', Environmental Health, 11 1-8 (2012) [C1]
Citations Scopus - 27Web of Science - 8
Co-authors Catherine Deste, Milton Hasnat, Mark Mcevoy, Roseanne Peel
2012 Dudding TE, Attia JR, 'Maternal factor V Leiden and adverse pregnancy outcome: Deciding whether or not to test', Journal of Maternal-Fetal & Neonatal Medicine, 25 889-894 (2012) [C1]
Citations Scopus - 4Web of Science - 1
Co-authors Tracy Dudding
2012 White JH, Magin PJ, Attia JR, Sturm J, Carter GL, Pollack M, 'Trajectories of psychological distress after stroke', Annals of Family Medicine, 10 435-442 (2012) [C1]
Citations Scopus - 13Web of Science - 9
Co-authors Gregory Carter, Parker Magin
2012 Islam MR, Khan I, Attia JR, Hassan SMN, McEvoy MA, D'Este CA, et al., 'Association between hypertension and chronic arsenic exposure in drinking water: A cross-sectional study in Bangladesh', International Journal of Environmental Research and Public Health, 9 4522-4536 (2012) [C1]
Citations Scopus - 11Web of Science - 5
Co-authors Mark Mcevoy, Milton Hasnat, Catherine Deste
2011 Numthavaj P, Thakkinstian A, Dejthevaporn C, Attia JR, 'Corticosteroid and antiviral therapy for Bell's palsy: A network meta-analysis', BMC Neurology, 11 1 (2011) [C1]
DOI 10.1186/1471-2377-11-1
Citations Scopus - 20Web of Science - 16
2011 Moxey AJ, McEvoy MA, Bowe SJ, Attia JR, 'Spirituality, religion, social support and health among older Australian adults', Australasian Journal on Ageing, 30 82-88 (2011) [C1]
DOI 10.1111/j.1741-6612.2010.00453.x
Citations Scopus - 8Web of Science - 3
Co-authors Mark Mcevoy
2011 Kypri K, McCambridge J, Wilson AJ, Attia JR, Sheeran P, Bowe S, Vater T, 'Effects of study design and allocation on participant behaviour- ESDA: Study protocol for a randomized controlled trial', Trials, 12 42 (2011) [C3]
DOI 10.1186/1745-6215-12-42
Citations Scopus - 18Web of Science - 18
Co-authors Kypros Kypri, Amanda Wilson
2011 Thakkinstian A, McKay GJ, McEvoy MA, Chakravarthy U, Chakrabarti S, Silvestri G, et al., 'Systematic review and meta-analysis of the association between complement component 3 and age-related macular degeneration: A HuGE review and meta-analysis', American Journal of Epidemiology, 173 1365-1379 (2011) [C1]
DOI 10.1093/aje/kwr025
Citations Scopus - 53Web of Science - 41
Co-authors Mark Mcevoy
2011 Reid A, Glass DC, Bailey HD, Milne E, de Klerk NH, Downie P, Fritschi L, 'Risk of childhood acute lymphoblastic leukaemia following parental occupational exposure to extremely low frequency electromagnetic fields', BRITISH JOURNAL OF CANCER, 105 1409-1413 (2011) [C1]
DOI 10.1038/bjc.2011.365
Citations Scopus - 8Web of Science - 5
2011 Bailey HD, Milne E, De Klerk NH, Fritschi L, Attia JR, Cole C, Armstrong BK, 'Exposure to house painting and the use of floor treatments and the risk of childhood acute lymphoblastic leukemia', International Journal of Cancer, 128 2405-2414 (2011) [C1]
DOI 10.1002/ijc.25572
Citations Scopus - 11Web of Science - 10
2011 Bailey HD, Armstrong BK, De Klerk NH, Fritschi L, Attia JR, Scott R, et al., 'Exposure to professional pest control treatments and the risk of childhood acute lymphoblastic leukemia', International Journal of Cancer, 129 1678-1688 (2011) [C1]
Citations Scopus - 14Web of Science - 13
Co-authors Rodney Scott
2011 Ongugo K, Hall JJ, Attia JR, 'Implementing tuberculosis control in Papua New Guinea: A clash of culture and science?', Journal of Community Health, 36 423-430 (2011) [C1]
DOI 10.1007/s10900-010-9324-8
Citations Scopus - 4Web of Science - 5
Co-authors John Hall
2011 Thakkinstian A, Attia JR, 'Treatment of chronic prostatitis/chronic pelvic pain syndrome - Reply', JAMA - Journal of the American Medical Association, 305 1298-1299 (2011) [C3]
2011 Anothaisintawee T, Attia JR, Nickel JC, Thammakraisorn S, Numthavaj P, McEvoy MA, Thakkinstian A, 'Management of chronic prostatitis/ Chronic pelvic pain syndrome: A systematic review and network meta-analysis', JAMA: The Journal of the American Medical Association, 305 78-86 (2011) [C1]
DOI 10.1001/jama.2010.1913
Citations Scopus - 78Web of Science - 57
Co-authors Mark Mcevoy
2011 Ngamjanyaporn P, Thakkinstian A, Verasertniyom O, Chatchaipun P, Vanichapuntu M, Nantiruj K, et al., 'Pharmacogenetics of cyclophosphamide and CYP2C19 polymorphism in Thai systemic lupus erythematosus', Rheumatology International, 31 1215-1218 (2011) [C1]
DOI 10.1007/s00296-010-1420-7
Citations Scopus - 9Web of Science - 3
2011 Bailey HD, De Klerk NH, Fritschi L, Attia JR, Daubenton JD, Armstrong BK, Milne E, 'Refuelling of vehicles, the use of wood burners and the risk of acute lymphoblastic leukaemia in childhood', Paediatric and Perinatal Epidemiology, 25 528-539 (2011) [C1]
Citations Scopus - 4Web of Science - 4
2011 Guest M, D'Este CA, Attia JR, Boggess M, Brown A, Tavener M, et al., 'Impairment of color vision in aircraft maintenance workers', International Archives of Occupational and Environmental Health, 84 723-733 (2011) [C1]
DOI 10.1007/s00420-010-0600-9
Citations Scopus - 1Web of Science - 1
Co-authors Catherine Deste, Meredith Tavener
2011 Osmotherly PG, McElduff P, Attia JR, 'Factor Structure of the Neck Disability Index RESPONSE', SPINE, 36 1816-1816 (2011) [C3]
DOI 10.1097/BRS.0b013e31822b4321
Co-authors Peter Osmotherly
2011 Pickering PM, Osmotherly PG, Attia JR, McElduff P, 'An examination of outcome measures for pain and dysfunction in the cervical spine: A factor analysis', Spine, 36 581-588 (2011) [C1]
DOI 10.1097/brs.0b013e3181d762da
Citations Scopus - 13Web of Science - 11
Co-authors Peter Osmotherly
2011 Osmotherly PG, McElduff P, Attia JR, 'In response: Factor structure of the Neck Disability Index', Spine, 36 1816 (2011) [C3]
Co-authors Peter Osmotherly
2011 Oldmeadow CJ, Riveros RC, Holliday EG, Scott R, Moscato PA, Wang JJ, et al., 'Sifting the wheat from the chaff: Prioritizing GWAS results by identifying consistency across analytical methods', Genetic Epidemiology, 35 745-754 (2011) [C1]
DOI 10.1002/gepi.20622
Citations Scopus - 6Web of Science - 5
Co-authors Christopher Oldmeadow, Pablo Moscato, Rodney Scott, Carlos Riveros, Liz Holliday
2011 Milne E, Royle JA, Bennett LC, De Klerk NH, Bailey HD, Bower C, et al., 'Maternal consumption of coffee and tea during pregnancy and risk of childhood ALL: Results from an Australian case-control study', Cancer Causes & Control, 22 207-218 (2011) [C1]
DOI 10.1007/s10552-010-9688-1
Citations Scopus - 9Web of Science - 6
Co-authors Rodney Scott
2011 Bryant JL, Bonevski B, Paul CL, McElduff P, Attia JR, 'A systematic review and meta-analysis of the effectiveness of behavioural smoking cessation interventions in selected disadvantaged groups', Addiction, 106 1568-1585 (2011) [C1]
DOI 10.1111/j.1360-0443.2011.03467.x
Citations Scopus - 33Web of Science - 27
Co-authors Chris Paul, Billie Bonevski
2011 Handley T, Inder KJ, Kelly BJ, Attia JR, Kay-Lambkin FJ, 'Urban-rural influences on suicidality: Gaps in the existing literature and recommendations for future research', Australian Journal of Rural Health, 19 279-283 (2011) [C1]
DOI 10.1111/j.1440-1584.2011.01235.x
Citations Scopus - 3Web of Science - 3
Co-authors Brian Kelly, Kerry Inder
2011 Maguire JM, Thakkinstian A, Levi CR, Lincz L, Bisset L, Sturm J, et al., 'Impact of COX-2 rs5275 and rs20417 and GPIIIa rs5918 polymorphisms on 90-day ischemic stroke functional outcome: A novel finding', Journal of Stroke and Cerebrovascular Diseases, 20 134-144 (2011) [C1]
DOI 10.1016/j.jstrokecerebrovasdis.2009.10.011
Citations Scopus - 22Web of Science - 22
Co-authors Chris Levi, Jane Maguire, Lisa Lincz, Rodney Scott
2011 McKay GJ, Patterson CC, Chakravarthy U, Dasari S, Klaver CC, Vingerling JR, et al., 'Evidence of association of APOE with age-related macular degeneration - A pooled analysis of 15 studies', Human Mutation, 32 1407-1416 (2011) [C1]
Citations Scopus - 44Web of Science - 32
2011 Khor CC, Davila S, Breunis WB, Lee YC, Shimizu C, Wright VJ, et al., 'Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease', Nature Genetics, 43 1241-1248 (2011) [C1]
Citations Scopus - 104Web of Science - 82
Co-authors Liz Holliday, Rodney Scott
2011 Guest M, Boggess MM, D'Este CA, Attia JR, Brown A, 'An observed relationship between vestibular function and auditory thresholds in aircraft-maintenance workers', Journal of Occupational and Environmental Medicine, 53 146-152 (2011) [C1]
DOI 10.1097/jom.0b013e318204fa7f
Citations Scopus - 3Web of Science - 3
Co-authors Catherine Deste
2011 Guest M, Attia JR, D'Este CA, Boggess MM, Brown AM, Gibson RE, et al., 'Peripheral neuropathy in military aircraft maintenance workers in Australia', Journal of Occupational and Environmental Medicine, 53 381-387 (2011) [C1]
DOI 10.1097/jom.0b013e318212226d
Co-authors Meredith Tavener, Catherine Deste
2011 Thomas L, Rivett DA, Attia JR, Parsons MW, Levi CR, 'Risk factors and clinical features of craniocervical arterial dissection', Manual Therapy, 16 351-356 (2011) [C1]
DOI 10.1016/j.math.2010.12.008
Citations Scopus - 23Web of Science - 18
Co-authors Mark Parsons, Chris Levi, Lucy Thomas, Darren Rivett
2011 Jones LJ, Craven P, Attia JR, Thakkinstian A, Wright IM, 'Network meta-analysis of indomethacin versus ibuprofen versus placebo for PDA in preterm infants', Archives of Disease in Childhood-Fetal and Neonatal Edition, 96 F45-F52 (2011) [C1]
DOI 10.1136/adc.2009.168682
Citations Scopus - 34Web of Science - 27
Co-authors Ian Wright
2011 McGettigan P, Lincz L, Attia JR, McElduff P, Bissett L, Peel R, et al., 'The risk of coronary thrombosis with cyclo-oxygenase-2 inhibitors does not vary with polymorphisms in two regions of the cyclo-oxygenase-2 gene', British Journal of Clinical Pharmacology, 72 707-714 (2011) [C1]
DOI 10.1111/j.1365-2125.2011.03957.x
Citations Scopus - 6Web of Science - 7
Co-authors Lisa Lincz, Roseanne Peel, Mddah01, Barrie Stokes
2011 Gwynn JD, Flood VM, D'Este CA, Attia JR, Turner N, Cochrane J, Wiggers JH, 'The reliability and validity of a short FFQ among Australian Aboriginal and Torres Strait Islander and non-Indigenous rural children', Public Health Nutrition, 14 388-401 (2011) [C1]
DOI 10.1017/s1368980010001928
Citations Scopus - 12Web of Science - 9
Co-authors Catherine Deste, John Wiggers, Josephine Gwynn
2011 Nair BR, Heim C, Krishnan C, D'Este CA, Marley J, Attia JR, 'The effect of Baroque music on behavioural disturbances in patients with dementia', Australasian Journal on Ageing, 30 11-15 (2011) [C1]
DOI 10.1111/j.1741-6612.2010.00439.x
Citations Scopus - 7Web of Science - 2
Co-authors Catherine Deste
2011 Ranasinghe WKB, Wright TA, Attia JR, McElduff P, Doyle T, Bartholomew M, et al., 'Effects of bariatric surgery on urinary and sexual function', BJU International, 107 88-94 (2011) [C1]
DOI 10.1111/j.1464-410x.2010.09509.x
Citations Scopus - 16Web of Science - 11
2011 Thompson JR, Attia JR, Minelli C, 'The meta-analysis of genome-wide association studies', Briefings in Bioinformatics, 12 259-269 (2011) [C1]
DOI 10.1093/bib/bbr020
Citations Scopus - 26Web of Science - 20
2011 Murphy VE, Namazy JA, Powell H, Schatz M, Chambers C, Attia JR, Gibson PG, 'A meta-analysis of adverse perinatal outcomes in women with asthma', BJOG: An International Journal of Obstetrics and Gynaecology, 118 1314-1323 (2011) [C1]
DOI 10.1111/j.1471-0528.2011.03055.x
Citations Scopus - 89Web of Science - 58
Co-authors Vanessa Murphy, Peter Gibson
2010 Lees KR, Bluhmki E, Von Kummer R, Brott TG, Toni D, Grotta JC, et al., 'Time to treatment with intravenous alteplase and outcome in stroke: an updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials', The Lancet, 375 1695-1703 (2010) [C1]
DOI 10.1016/S0140-6736(10)60491-6
Citations Scopus - 875Web of Science - 688
Co-authors Chris Levi, Mark Parsons
2010 Tran HA, Reeves GEM, Lyons TJ, Attia JR, 'Histopathologic findings of autoimmunity in thyroid, pituitary, and adrenal diseases in chronic Hepatitis C postmortem cases', Endocrine Practice, 16 566-569 (2010) [C1]
DOI 10.4158/EP09359.OR
Citations Scopus - 1
2010 Attia JR, Thakkinstian A, McElduff P, Milne E, Dawson S, Scott R, et al., 'Detecting genotyping error using measures of degree of Hardy-Weinberg disequilibrium', Statistical Applications in Genetics and Molecular Biology, 9 17 (2010) [C1]
DOI 10.2202/1544-6115.1463
Citations Scopus - 10Web of Science - 5
Co-authors Rodney Scott
2010 Janssen H, Bernhardt J, Collier JM, Sena ES, McElduff P, Attia JR, et al., 'An enriched environment improves sensorimotor function post-ischemic stroke', Neurorehabilitation and Neural Repair, 24 802-813 (2010) [C1]
DOI 10.1177/1545968310372092
Citations Scopus - 40Web of Science - 30
Co-authors Neil Spratt
2010 Ikram MK, Xueling S, Jensen RA, Cotch MF, Hewitt AW, Ikram MA, et al., 'Four Novel Loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation In Vivo', Plos Genetics, 6 1-12 (2010) [C1]
DOI 10.1371/journal.pgen.1001184
Citations Scopus - 63Web of Science - 54
Co-authors Rodney Scott, Liz Holliday
2010 Proietto AM, Otton GR, Symonds IM, McEvoy MA, Attia JR, Gilbert M, et al., 'Polymorphisms in genes of the steroid hormone biosynthesis and metabolism pathways and endometrial cancer risk', Cancer Epidemiology, 34 328-337 (2010) [C1]
DOI 10.1016/j.canep.2010.03.005
Citations Scopus - 31Web of Science - 27
Co-authors Mark Mcevoy, Ian Symonds, Rodney Scott
2010 Wang JJ, Attia JR, 'Study Designs in Epidemiology and Levels of Evidence', American Journal of Ophthalmology, 149 367-370 (2010) [C2]
Citations Scopus - 4Web of Science - 3
2010 Holliday EG, Scott R, Attia JR, 'Evidence-based medicine in the era of biomarkers: Teaching a new dog old tricks?', Clinical Pharmacology and Therapeutics, 88 740-742 (2010) [C2]
DOI 10.1038/clpt.2010.214
Citations Scopus - 4Web of Science - 2
Co-authors Liz Holliday, Rodney Scott
2010 Smith DR, Attia JR, McEvoy MA, 'Exploring new frontiers in occupational epidemiology: The Hunter Community Study (HCS) from Australia', Industrial Health, 48 244-248 (2010) [C1]
DOI 10.2486/indhealth.48.244
Citations Scopus - 5Web of Science - 5
Co-authors Mark Mcevoy
2010 Milne E, Royle JA, Miller M, Bower C, De Klerk NH, Bailey HD, et al., 'Maternal folate and other vitamin supplementation during pregnancy and risk of acute lymphoblastic leukemia in the offspring', International Journal of Cancer, 126 2690-2699 (2010) [C1]
DOI 10.1002/ijc.24969
Citations Scopus - 37Web of Science - 29
Co-authors Rodney Scott
2010 Schofield PW, Lee SJ, Lewin TJ, Lyall G, Moyle J, Attia JR, McEvoy MA, 'The Audio Recorded Cognitive Screen (ARCS): A flexible hybrid cognitive test instrument', Journal of Neurology Neurosurgery and Psychiatry, 81 602-607 (2010) [C1]
DOI 10.1136/jnnp.2009.188003
Citations Scopus - 15Web of Science - 11
Co-authors Mark Mcevoy, Peter Schofield, Terry Lewin
2010 Kamanamool N, McEvoy MA, Attia JR, Ingsathit A, Ngamjanyaporn P, Thakkinstian A, 'Efficacy and adverse events of mycophenolate mofetil versus cyclophosphamide for induction therapy of lupus nephritis: Systematic review and meta-analysis', Medicine, 89 227-235 (2010) [C1]
DOI 10.1097/MD.0b013e3181e93d00
Citations Scopus - 38Web of Science - 25
Co-authors Mark Mcevoy
2010 Lemmens R, Buysschaert I, Geelen V, Fernandez-Cadenas I, Montaner J, Schmidt H, et al., 'The Association of the 4q25 susceptibility variant for atrial fibrillation with stroke is limited to stroke of cardioembolic etiology', Stroke, 41 1850-1857 (2010) [C1]
DOI 10.1161/STROKEAHA.110.587980
Citations Scopus - 30Web of Science - 27
Co-authors Chris Levi, Jane Maguire
2010 Limsuwan T, Thakkinstian A, Verasertniyom O, Vanichapuntu M, Attia JR, Janwityanujit S, Nantiruj K, 'Possible protective effects of the Glu27 allele of beta(2)-Adrenergic receptor polymorphism in Thai asthmatic patients', Asian Pacific Journal of Allergy and Immunology, 28 107-114 (2010) [C1]
Citations Scopus - 3Web of Science - 2
2010 Bailey HD, Milne E, De Klerk N, Fritschi L, Bower C, Attia JR, Armstrong BK, 'Representativeness of child controls recruited by random digit dialling', Paediatric and Perinatal Epidemiology, 24 293-302 (2010) [C1]
DOI 10.1111/j.1365-3016.2010.01099.x
Citations Scopus - 28Web of Science - 27
2010 Guest M, Boggess M, Attia JR, D'Este CA, Brown A, Gibson RE, et al., 'Hearing impairment in F-111 maintenance workers: The study of health outcomes in aircraft maintenance personnel (SHOAMP) general health and medical study', American Journal of Industrial Medicine, 53 1159-1169 (2010) [C1]
DOI 10.1002/ajim.20867
Citations Scopus - 9Web of Science - 8
Co-authors Catherine Deste, Meredith Tavener
2010 McEvoy MA, Smith WT, D'Este CA, Duke JM, Peel R, Schofield PW, et al., 'Cohort Profile: The Hunter Community Study', International Journal of Epidemiology, 39 1452-1463 (2010) [C1]
DOI 10.1093/ije/dyp343
Citations Scopus - 65Web of Science - 58
Co-authors Roseanne Peel, Rodney Scott, Catherine Deste, Wayne Smith, Mark Mcevoy, Peter Schofield, Mddah01, Ben Ewald, Julie Byles
2010 Ewald BD, McEvoy MA, Attia JR, 'Pedometer counts superior to physical activity scale for identifying health markers in older adults', British Journal of Sports Medicine, 44 756-761 (2010) [C1]
DOI 10.1136/bjsm.2008.048827
Citations Scopus - 14Web of Science - 9
Co-authors Ben Ewald, Mark Mcevoy
2010 Wood LG, Attia JR, McElduff P, McEvoy MA, Gibson PG, 'Assessment of dietary fat intake and innate immune activation as risk factors for impaired lung function', European Journal of Clinical Nutrition, 64 818-825 (2010) [C1]
DOI 10.1038/ejcn.2010.68
Citations Scopus - 6Web of Science - 5
Co-authors Mark Mcevoy, Lisa Wood, Peter Gibson
2010 Marsden DL, Spratt NJ, Walker R, Barker DJ, Attia JR, Pollack MR, et al., 'Trends in stroke attack rates and case fatality in the Hunter Region, Australia 1996-2008', Cerebrovascular Diseases, 30 500-507 (2010) [C1]
DOI 10.1159/000319022
Citations Scopus - 17Web of Science - 16
Co-authors Mark Parsons, Chris Levi, Neil Spratt
2010 Hiew C, Williams T, Hatton R, Narasimhan S, O'Connor S, Baker F, et al., 'Influence of age on long-term outcome after emergent percutaneous coronary intervention for ST-elevation myocardial infarction', Journal of Invasive Cardiology, 22 273-277 (2010) [C1]
Citations Scopus - 5Web of Science - 3
2010 Bailey HD, Armstrong BK, De Klerk NH, Fritschi L, Attia JR, Lockwood L, et al., 'Exposure to Diagnostic Radiological Procedures and the Risk of Childhood Acute Lymphoblastic Leukemia', Cancer Epidemiology Biomarkers & Prevention, 19 2897-2909 (2010) [C1]
DOI 10.1158/1055-9965.EPI-10-0542
Citations Scopus - 11Web of Science - 5
2010 Gwynn JD, Hardy LL, Wiggers JH, Smith WT, D'Este CA, Turner N, et al., 'The validation of a self-report measure and physical activity of Australian Aboriginal and Torres Strait Islander and non-Indigenous rural children', Australian and New Zealand Journal of Public Health, 34 S57-S65 (2010) [C1]
DOI 10.1111/j.1753-6405.2010.00555.x
Citations Scopus - 11Web of Science - 8
Co-authors Josephine Gwynn, John Wiggers, Catherine Deste, Wayne Smith
2010 Arj-Ong S, Thakkinstian A, McEvoy MA, Attia JR, 'A systematic review and meta-analysis of tumor necrosis factor alpha-308 polymorphism and Kawasaki disease', Pediatrics International, 52 527-532 (2010) [C1]
DOI 10.1111/j.1442-200X.2010.03105.x
Citations Scopus - 13Web of Science - 10
Co-authors Mark Mcevoy
2010 Gupta SK, McGrath S, Rogers K, Attia JR, Lewis G, Viswanathan S, et al., 'Fixed dose (555 MBq; 15 mCi) radioiodine for the treatment of hyperthyroidism: outcome and its predictors', Internal Medicine Journal, 40 854-857 (2010) [C1]
DOI 10.1111/j.1445-5994.2010.02348.x
Citations Scopus - 9Web of Science - 6
2010 Ashton KA, Proietto AM, Otton GR, Symonds IM, McEvoy MA, Attia JR, Scott R, 'Toll-Like Receptor (TLR) and Nucleosome-binding Oligomerization Domain (NOD) gene polymorphisms and endometrial cancer risk', BMC Cancer, 10 1-7 (2010) [C1]
DOI 10.1186/1471-2407-10-382
Citations Scopus - 26Web of Science - 24
Co-authors Ian Symonds, Mark Mcevoy, Rodney Scott
2010 Loten C, Attia JR, Hullick C, Marley J, McElduff P, 'Point of care troponin decreases time in the emergency department for patients with possible acute coronary syndrome: A randomised controlled trial', Emergency Medicine Journal, 27 194-198 (2010) [C1]
DOI 10.1136/emj.2008.069427
Citations Scopus - 14Web of Science - 8
2009 Ashton KA, Proietto AM, Otton GR, Symonds IM, McEvoy MA, Attia JR, et al., 'Estrogen receptor polymorphisms and the risk of endometrial cancer', BJOG: An International Journal of Obstetrics and Gynaecology, 116 1053-1061 (2009) [C1]
DOI 10.1111/j.1471-0528.2009.02185.x
Citations Scopus - 30Web of Science - 26
Co-authors Rodney Scott, Mark Mcevoy, Ian Symonds
2009 Loten C, Attia JR, Hullick C, Marley J, McElduff P, 'Validation of a point of care troponin assay in real life emergency department conditions', Emergency Medicine Australasia, 21 286-292 (2009) [C1]
DOI 10.1111/j.1742-6723.2009.01198.x
Citations Scopus - 5Web of Science - 3
2009 Loten C, Isbister GK, Jamcotchian MA, Hullick C, McElduff P, Attia JR, Marley J, 'Adverse outcomes following emergency department discharge of patients with possible acute coronary syndrome', Emergency Medicine Australasia, 21 455-464 (2009) [C1]
DOI 10.1111/j.1742-6723.2009.01229.x
Citations Scopus - 5Web of Science - 5
Co-authors Geoff Isbister
2009 Brown A, Gibson RE, Tavener MA, Guest M, D'Este CA, Byles JE, et al., 'Sexual function in F-111 maintenance workers: The study of health outcomes in aircraft maintenance personnel', Journal of Sexual Medicine, 6 1569-1578 (2009) [C1]
DOI 10.1111/j.1743-6109.2009.01237.x
Citations Scopus - 3Web of Science - 3
Co-authors Meredith Tavener, Julie Byles, Catherine Deste
2009 Milne E, Royle JA, De Klerk NH, Blair E, Bailey H, Cole C, et al., 'Fetal growth and risk of childhood acute lymphoblastic leukemia: Results from an Australian case-control study', American Journal of Epidemiology, 170 221-228 (2009) [C1]
DOI 10.1093/aje/kwp117
Citations Scopus - 28Web of Science - 27
Co-authors Rodney Scott
2009 Minelli C, Thompson JR, Abrams KR, Thakkinstian A, Attia JR, 'The quality of meta-analyses of Genetic Association Studies: A veview with recommendations', American Journal of Epidemiology, 170 1333-1343 (2009) [C1]
DOI 10.1093/aje/kwp350
Citations Scopus - 26Web of Science - 25
2009 Miles S, Rogers KM, Thomas P, Soans B, Attia JR, Abel C, et al., 'A comparison of single-photon emission CT lung scintigraphy and CT pulmonary angiography for the diagnosis of pulmonary embolism', Chest, 136 1546-1553 (2009) [C1]
DOI 10.1378/chest.09-0361
Citations Scopus - 41Web of Science - 31
Co-authors Michael Hensley, Catherine Deste
2009 McCambridge J, Kypri K, Attia JR, Elbourne D, 'Re: Promoting regular mammography screening I: A systematic assessment of validity in a randomized trial', Journal of the National Cancer Institute, 101 1029-1030 (2009) [C3]
DOI 10.1093/jnci/djp154
Citations Scopus - 2Web of Science - 2
Co-authors Kypros Kypri
2009 Parsons MW, Miteff F, Bateman GA, Spratt NJ, Loiselle A, Attia JR, Levi CR, 'Acute ischemic stroke imaging-guided tenecteplase treatment in an extended time window', Neurology, 72 915-921 (2009) [C1]
DOI 10.1212/01.wnl.0000344168.05315.9d
Citations Scopus - 71Web of Science - 49
Co-authors Chris Levi, Neil Spratt, Mark Parsons
2009 Hallinan R, Crettol S, Agho K, Attia JR, Besson J, Croquette-Krokar M, et al., 'Cannabis and benzodiazepines as determinants of methadone trough plasma concentration variability in maintenance treatment: A transnational study', European Journal of Clinical Pharmacology, 65 1113-1120 (2009) [C1]
DOI 10.1007/s00228-009-0706-8
Citations Scopus - 11Web of Science - 9
2009 Ashton KA, Proietto AM, Otton GR, Symonds IM, McEvoy MA, Attia JR, et al., 'Polymorphisms in TP53 and MDM2 combined are associated with high grade endometrial cancer', Gynecologic Oncology, 113 109-114 (2009) [C1]
DOI 10.1016/j.ygyno.2008.12.036
Citations Scopus - 28Web of Science - 26
Co-authors Rodney Scott, Mark Mcevoy, Ian Symonds
2009 Attia JR, Ioannidis JPA, Thakkinstian A, McEvoy MA, Scott R, Minelli C, et al., 'How to use an article about genetic association A: Background concepts', JAMA: Journal of the American Medical Association, 301 74-81 (2009) [C1]
DOI 10.1001/jama.2008.901
Citations Scopus - 61Web of Science - 56
Co-authors Rodney Scott, Mark Mcevoy
2009 Attia JR, Ioannidis JPA, Thakkinstian A, McEvoy MA, Scott R, Minelli C, et al., 'How to use an article about genetic association B: Are the results of the study valid?', JAMA: Journal of the American Medical Association, 301 191-197 (2009) [C1]
DOI 10.1001/jama.2008.946
Citations Scopus - 91Web of Science - 87
Co-authors Mark Mcevoy, Rodney Scott
2009 Attia JR, Ioannidis JPA, Thakkinstian A, McEvoy MA, Scott R, Minelli C, et al., 'How to use an article about genetic association C: What are the results and will they help me in caring for my patients?', JAMA: Journal of the American Medical Association, 301 304-308 (2009) [C1]
DOI 10.1001/jama.2008.993
Citations Scopus - 46Web of Science - 39
Co-authors Mark Mcevoy, Rodney Scott
2009 Hallinan R, Byrne A, Agho K, McMahon CG, Tynan P, Attia JR, 'Hypogonadism in men receiving methadone and buprenorphine maintenance treatment', International Journal of Andrology, 32 131-139 (2009) [C1]
DOI 10.1111/j.1365-2605.2007.00824.x
Citations Scopus - 37Web of Science - 21
2009 Thakkinstian A, Thompson JR, Minelli C, Attia JR, 'Choosing between per-genotype, per-allele, and trend approaches for initial detection of gene-disease association', Journal of Applied Statistics, 36 633-646 (2009) [C1]
DOI 10.1080/02664760802484990
Citations Scopus - 16Web of Science - 13
2009 Anothaisintawee T, Rattanasiri S, Ingsathit A, Attia JR, Thakkinstian A, 'Prevalence of chronic kidney disease: A systematic review and meta-analysis', Clinical Nephrology, 71 244-254 (2009) [C1]
Citations Scopus - 13Web of Science - 11
2009 Lowe J, Mensch M, McElduff P, Fitzgerald M, Attia JR, 'Does an advanced insulin education programme improve outcomes and health service use for people with Type 2 diabetes? A 5-year follow-up of the Newcastle Empowerment course', Diabetic Medicine, 26 1277-1281 (2009) [C1]
DOI 10.1111/j.1464-5491.2009.02858.x
Citations Scopus - 2Web of Science - 1
2009 Narasimhan S, McKay K, Attia JR, 'Staff perspectives of a cardiac short stay unit', Australian Journal of Advanced Nursing, 26 23-28 (2009) [C1]
Citations Scopus - 1Web of Science - 1
2009 Tran HA, Reeves GE, Gibson R, Attia JR, 'Development of thyroid diseases in the treatment of chronic hepatitis C with alpha-interferon may be a good prognosticator in achieving a sustained virological response: A meta-analysis', Journal of Gastroenterology and Hepatology, 24 1163-1168 (2009) [C1]
DOI 10.1111/j.1440-1746.2009.05874.x
Citations Scopus - 15Web of Science - 12
2009 MacDonald K, Lowe J, Barker DJ, Mensch M, Attia JR, 'Effect of popular takeaway foods on blood glucose levels in type 1 diabetes mellitus patients on intensive insulin therapy', International Journal of Clinical Practice, 63 189-194 (2009) [C1]
DOI 10.1111/j.1742-1241.2008.01970.x
Citations Scopus - 9Web of Science - 6
2009 Xu L, Dibley M, D'Este CA, Phillips M, Porteous JE, Attia JR, 'Food groups and risk of forearm fractures in postmenopausal women in Chengdu, China', Climacteric, 12 222-229 (2009) [C1]
DOI 10.1080/13697130802626958
Citations Scopus - 9Web of Science - 7
Co-authors Catherine Deste
2009 Ewald BD, Duke JM, Thakkinstian A, Attia JR, Smith WT, 'Physical activity of older Australians measured by pedometry', Australasian Journal on Ageing, 28 127-133 (2009) [C1]
DOI 10.1111/j.1741-6612.2009.00372.x
Citations Scopus - 14Web of Science - 11
Co-authors Wayne Smith, Ben Ewald
2008 Osmotherly PG, Attia JR, Thakkinstian A, 'Can clinical measures of upper quarter postural muscle performance predict neck pain in visual display terminal operators?', Journal of Back and Musculoskeletal Rehabilitation, 21 113-120 (2008) [C1]
Citations Scopus - 1
Co-authors Peter Osmotherly
2008 Ewald BD, Ewald D, Thakkinstian A, Attia JR, 'Meta-analysis of B type natriuretic peptide and N-terminal pro B natriuretic peptide in the diagnosis of clinical heart failure and population screening for left ventricular systolic dysfunction', Internal Medicine Journal, 38 101-113 (2008) [C1]
DOI 10.1111/j.1445-5994.2007.01454.x
Citations Scopus - 52Web of Science - 44
Co-authors Ben Ewald
2008 Ashton KA, Proietto AM, Otton GR, Symonds IM, McEvoy MA, Attia JR, et al., 'The influence of the Cyclin D1 870 G>A polymorphism as an endometrial cancer risk factor', BMC Cancer, 8 1-6 (2008) [C1]
DOI 10.1186/1471-2407-8-272
Citations Scopus - 7Web of Science - 6
Co-authors Mark Mcevoy, Ian Symonds, Rodney Scott
2008 Davis SM, Donnan GA, Parsons MW, Levi CR, Butcher KS, Peeters A, et al., 'Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): A placebo-controlled randomised trial', The Lancet Neurology, 7 299-309 (2008) [C1]
DOI 10.1016/s1474-4422(08)70044-9
Citations Scopus - 581Web of Science - 492
Co-authors Mark Parsons, Chris Levi
2008 Dudding TE, Heron J, Thakkinstian A, Nurk E, Golding J, Pembrey M, et al., 'Factor V Leiden is associated with pre-eclampsia but not with fetal growth restriction: A genetic association study and meta-analysis', Journal of Thrombosis and Haemostasis, 6 1868-1875 (2008) [C1]
DOI 10.111/j.1538-7836.2008.03134.x
Citations Scopus - 32Web of Science - 5
Co-authors Rodney Scott, Tracy Dudding
2008 Hallinan R, Byrne A, Agho K, McMahon C, Tynan P, Attia JR, 'Erectile dysfunction in men receiving methadone and buprenorphine maintenance treatment', Journal of Sexual Medicine, 5 684-692 (2008) [C1]
DOI 10.1111/j.1743-6109.2007.00702.x
Citations Scopus - 58Web of Science - 46
2008 Ryan RL, King BR, Anderson DG, Attia JR, Collins CE, Smart CE, 'Influence of and optimal insulin therapy for a low-glycemic index meal in children with type 1 diabetes receiving intensive insulin therapy', Diabetes Care, 31 1485-1490 (2008) [C1]
DOI 10.2337/dc08-0331
Citations Scopus - 18Web of Science - 10
Co-authors Clare Collins, Bruce King
2008 Minelli C, Thompson JR, Abrams KR, Thakkinstian A, Attia JR, 'How should we use information about HWE in the meta-analyses of genetic association studies', International Journal of Epidemiology, 37 136-146 (2008) [C1]
DOI 10.1093/ije/dym234
Citations Scopus - 69Web of Science - 59
2008 White JH, Magin PJ, Attia JR, Pollack MR, Sturm J, Levi CR, 'Exploring poststroke mood changes in community-dwelling stroke survivors: A qualitative study', Archives of Physical Medicine and Rehabilitation, 89 1701-1707 (2008) [C1]
DOI 10.1016/j.apmr.2007.12.048
Citations Scopus - 15Web of Science - 12
Co-authors Parker Magin, Chris Levi
2008 Quain DA, Parsons MW, Loudfoot AR, Spratt NJ, Evans MK, Russell ML, et al., 'Improving access to acute stroke therapies: A controlled trial of organised pre-hospital and emergency care', Medical Journal of Australia, 189 429-433 (2008) [C1]
Citations Scopus - 67Web of Science - 51
Co-authors Neil Spratt, Mark Parsons, Chris Levi
2008 Thompson JR, Minelli C, Abrams KR, Thakkinstian A, Attia JR, 'Combining information from related meta-analyses of genetic association studies', Journal of the Royal Statistical Society: Applied Statistics, 57 103-115 (2008) [C1]
DOI 10.1111/j.1467-9876.2007.00603.x
Citations Scopus - 3Web of Science - 3
2008 Maguire JM, Thakkinstian A, Sturm J, Levi CR, Lincz L, Parsons MW, et al., 'Polymorphisms in platelet glycoprotein 1b [alpha] and factor VII and risk of ischemic stroke', Stroke, 39 1710-1716 (2008) [C1]
DOI 10.1161/strokeaha.107.507228
Citations Scopus - 24Web of Science - 23
Co-authors Chris Levi, Mark Parsons, Lisa Lincz, Jane Maguire
2008 Lowe J, Linjawi S, Mensch M, James K, Attia JR, 'Flexible eating and flexible insulin dosing in patients with diabetes: Results of an intensive self-management course', Diabetes Research and Clinical Practice, 80 439-443 (2008) [C1]
DOI 10.1016/j.diabres.2008.02.003
Citations Scopus - 40Web of Science - 30
2008 D'Este CA, Attia JR, Brown AM, Gibson RE, Gibberd RW, Tavener MA, et al., 'Cancer incidence and mortality in aircraft maintenance workers', American Journal of Industrial Medicine, 51 16-23 (2008) [C1]
DOI 10.1002/ajim.20540
Citations Scopus - 5Web of Science - 5
Co-authors Robert Gibberd, Meredith Tavener, Catherine Deste
2008 Shi Z, McEvoy MA, Luu J, Attia JR, 'Dietary fat and sleep duration in Chinese men and women', International Journal of Obesity, 32 1835-1840 (2008) [C1]
DOI 10.1038/ijo.2008.191
Citations Scopus - 32Web of Science - 26
Co-authors Mark Mcevoy
2008 Thakkinstian A, Tran HA, Reeves GE, Murch S, Attia JR, 'A clinical decision rule to aid ordering of serum and urine protein electrophoresis for case-finding of paraproteins in hospitalized inpatients', Journal of General Internal Medicine, 23 1688-1692 (2008) [C1]
DOI 10.1007/s11606-008-0712-z
Citations Scopus - 1
2008 Thakkinstian A, Dmitrienko S, Gerbase-Delima M, McDaniel DO, Inigo P, Chow KM, et al., 'Association between cytokine gene polymorphisms and outcomes in renal transplantation: A meta-analysis of individual patient data', Nephrology Dialysis Transplantation, 23 3017-3023 (2008) [C1]
DOI 10.1093/ndt/gfn185
Citations Scopus - 34Web of Science - 30
Co-authors Mark Mcevoy
2008 Osmotherly PG, Attia JR, 'The interplay of static and dynamic postural factors in neck pain', Hong Kong Physiotherapy Journal, 26 9-17 (2008) [C1]
DOI 10.1016/S1013-7025(09)70003-X
Citations Scopus - 2
Co-authors Peter Osmotherly
2007 Tran HA, Attia JR, Jones TL, Batey RG, 'Pegylated interferon-alpha 2 beta in combination with ribavirin does not aggravate thyroid dysfunction in comparison to regular interferon-alpha 2 beta in a hepatitis C population: Meta-analysis', Journal of Gastroenterology and Hepatology, 22 472-476 (2007) [C1]
DOI 10.1111/j.1440-1746.2006.04771.x
Citations Scopus - 23Web of Science - 20
2007 Attia JR, Thakkinstian A, Wang Y, Lincz L, Parsons MW, Sturm J, et al., 'The PAI-1 4G/5G gene polymorphism and ischemic stroke: An association study and meta-analysis', Journal of Stroke and Cerebrovascular Diseases, 16 173-179 (2007) [C1]
DOI 10.1016/j.jstrokecerebrovasdis.2007.03.002
Citations Scopus - 31
Co-authors Chris Levi, Rodney Scott, Lisa Lincz, Mark Parsons
2007 Bailey H, Henley N, Robertson L, Armstrong B, Attia JR, Milne E, 'Applying Persuasion Principles Did Not Increase Questionnaire Response: A Randomised Controlled Trial of a Fridge Magnet Gift', Australasian Epidemiologist, 14 6-10 (2007) [C1]
2007 White JH, Alston MK, Marquez JL, Sweetapple AL, Pollack MR, Attia JR, et al., 'Community-Dwelling Stroke Survivors: Function Is Not the Whole Story With Quality of Life', Archives of Physical Medicine and Rehabilitation, 88 1140-1146 (2007) [C1]
DOI 10.1016/j.apmr.2007.06.003
Citations Scopus - 22Web of Science - 21
Co-authors Chris Levi
2007 Honoki K, Stojanovski E, McEvoy MA, Fujii H, Tsujiuchi T, Kido A, et al., 'Prognostic significance of p16(INK4a) alteration for Ewing sarcoma - A meta-analysis', Cancer, 110 1351-1360 (2007) [C1]
DOI 10.1002/cncr.22908
Citations Scopus - 19Web of Science - 16
Co-authors Elizabeth Stojanovski, Mark Mcevoy
2007 Duke JM, McEvoy MA, Sibbritt DW, Guest M, Smith WT, Attia JR, 'Vibrotactile threshold measurement for detecting peripheral neuropathy: Defining variability and a normal range for clinical and research use', Diabetologia, 50 2305-2312 (2007) [C1]
DOI 10.1007/s00125-007-0813-y
Citations Scopus - 18Web of Science - 16
Co-authors Wayne Smith, Mark Mcevoy
2007 Wark PA, Bucchieri F, Johnston SL, Gibson PG, Hamilton L, Mimica J, et al., 'IFN-gamma-induced protein 10 is a novel biomarker of rhinovirus-induced asthma exacerbations', Journal of Allergy and Clinical Immunology, 120 586-593 (2007) [C1]
DOI 10.1016/j.jaci.2007.04.046
Citations Scopus - 87Web of Science - 81
Co-authors Peter Wark, Joanna Latter, Peter Gibson
2006 Jm S, Ms S, Gj H, Attia JR, Thakkinstian A, Yi Q, et al., 'Association between phosphodiesterase 4D gene and ischaemic stroke', Journal of Neurology, Neurosurgery and Psychiatry Online, 77 1067-1069 (2006) [C1]
DOI 10.1136/jnnp.2006.092106
Citations Scopus - 52Web of Science - 48
2006 Schofield PW, Gibson RE, Tavener MA, Attia JR, D'Este CA, Guest M, et al., 'Neuropsychological health in F-111 aircraft maintenance workers', NeuroToxicology, 27 852-860 (2006) [C1]
DOI 10.1016/j.neuro.2006.02.002
Citations Scopus - 11Web of Science - 11
Co-authors Catherine Deste, Meredith Tavener, Peter Schofield
2006 Reeves GEM, Squance ML, Duggan AE, Murugasu RR, Wilson RJ, Wong RC, et al., 'Diagnostic accuracy of coeliac serological tests: a prospective study', EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 18 493-501 (2006)
DOI 10.1097/00042737-200605000-00006
Citations Scopus - 71Web of Science - 62
2006 Khoshdel A, Thakkinstian A, Carney SL, Attia JR, 'Estimation of an age-specific reference interval for pulse wave velocity: a meta-analysis', Journal of Hypertension, 24 1231-1237 (2006) [C1]
DOI 10.1097/01.hjh.0000234098.85497.31
Citations Scopus - 40Web of Science - 29
2006 Attia JR, Page JH, 'A graphic framework for teaching critical appraisal of randomised controlled trials', Equine Veterinary Journal, 38 7-9 (2006) [C1]
DOI 10.2746/042516406775374199
Citations Scopus - 1Web of Science - 1
2006 Thakkinstian A, Han PY, McEvoy MA, Smith WT, Hoh J, Magnusson K, et al., 'Systematic review and meta-analysis of the association between complementary factor HY402H polymorphisms and age-related macular degeneration', Human Molecular Genetics, 15 2784-2790 (2006) [C1]
DOI 10.1093/hmg/ddl220
Citations Scopus - 153Web of Science - 134
Co-authors Mark Mcevoy, Wayne Smith
2006 Hallinan R, Ray J, Byrne A, Agho KE, Attia JR, 'Therapeutic thresholds in methadone maintenance treatment: A receiver operating characteristic analysis', Drug and Alcohol Dependence, 81 129-136 (2006) [C1]
DOI 10.1016/j.drugalcdep.2005.06.005
Citations Scopus - 13Web of Science - 13
2006 Khoshdel A, Attia JR, Carney SL, 'Basic concepts in meta-analysis: a primer for clinicians', International Journal of Clinical Practice, 60 1287-1294 (2006) [C1]
DOI 10.1111/j.1742-1241.2006.01078.x
Citations Scopus - 22Web of Science - 17
2006 Zhang X, Attia JR, D'Este CA, Ma X-Y, 'The relationship between higher blood pressure and ischaemic, haemorrhagic stroke among Chinese and Caucasians: meta-analysis', European Journal of Cardiovascular Prevention and Rehabilitation, 13 429-437 (2006) [C1]
DOI 10.1097/01.hjr.0000214607.99113.b8
Citations Scopus - 22Web of Science - 16
Co-authors Catherine Deste
2006 Osmotherly PG, Attia JR, 'The healthy worker survivor effect in a study of neck muscle performance measures in call-centre operators', Work, 26 399-406 (2006) [C1]
Citations Scopus - 5
Co-authors Peter Osmotherly
2006 Xu L, Phillips M, D'Este CA, Dibley MJ, Porteous JE, Attia JR, 'Diet, activity, and other lifestyle risk factors for forearm fracture in postmenopausal women in China: a case-control study', Menopause - The Journal of the North American Menopause Society, 13 102-110 (2006) [C1]
DOI 10.1097/01.gme.0000191206.20738.da
Citations Scopus - 4Web of Science - 4
Co-authors Catherine Deste
2006 Attia JR, D'Este CA, Schofield PW, Brown AM, Gibson RE, Tavener MA, et al., 'Mental health in F-111 maintenance workers: the study of Health Outcomes in Aircraft Maintenance Personnel (SHOAMP) general health and medical study', Journal of Occupational and Environmental Medicine, 48 682-691 (2006) [C1]
DOI 10.1097/01.jom.0000205985.00559.84
Citations Scopus - 11Web of Science - 10
Co-authors Meredith Tavener, Catherine Deste, Peter Schofield
2006 Thakkinstian A, Bowe SJ, McEvoy MA, Smith WT, Attia JR, 'Association between apolipoprotein E polymorphisms and age-related macular degeneration: A HuGE review and meta-analysis', American Journal of Epidemiology, 164 813-822 (2006) [C1]
DOI 10.1093/aje/kwj279
Citations Scopus - 57Web of Science - 46
Co-authors Mark Mcevoy, Wayne Smith
2005 Thakkinstian A, McEvoy MA, Minelli C, Gibson PG, Hancox B, Duffy D, et al., 'Systematic review and meta-analysis of the association between beta(2)-adrenoceptor polymorphisms and asthma: A HuGE review', American Journal of Epidemiology, 162 201-211 (2005) [C1]
DOI 10.1093/aje/kwi184
Citations Scopus - 247Web of Science - 229
Co-authors Mark Mcevoy, Peter Gibson
2005 Minelli C, Thompson JR, Abrams KR, Thakkinstian A, Attia JR, 'The choice of a genetic model in the meta-analysis of molecular association studies', International Journal of Epidemiology, 34 1319-1328 (2005) [C1]
DOI 10.1093/ije/dyi169
Citations Scopus - 102Web of Science - 90
2005 Attia J, Schofield P, 'What now for Alzheimer's disease? An epidemiological evaluation of the AD2000 trial', Australian Prescriber, 28 134-135 (2005)
Citations Scopus - 1
Co-authors Peter Schofield
2005 Lindqvist PG, Merlo J, Dudding T, Attia J, 'Rebuttal: Meta-analysis of the relationship of factor V Leiden and intrauterine growth restriction-based on solid evidence? (multiple letters) [6]', Thrombosis and Haemostasis, 94 230-232 (2005)
Co-authors Tracy Dudding
2005 Zhang X, Attia JR, D'Este CA, Yu XH, Wu XG, 'A risk score predicted coronary heart disease and stroke in a Chinese cohort', Journal of Clinical Epidemiology, 58 951-958 (2005) [C1]
DOI 10.1016/j.jclinepi.2005.01.013
Citations Scopus - 30Web of Science - 22
Co-authors Catherine Deste
2005 Settakorn J, Rangdaeng S, Arpornchayanon O, Lekawanvijit S, Bhoopat L, Attia JR, 'Why were limbs amputated? An evaluation of 216 surgical specimens from Chiang Mai University', Archives of Orthopaedic and Trauma Surgery, 125 701-705 (2005) [C1]
DOI 10.1007/s00402-005-0060-y
Citations Scopus - 10Web of Science - 4
2005 Thakkinstian A, McElduff P, D'Este CA, Duffy D, Attia JR, 'A method for meta-analysis of molecular association studies', Statistics in Medicine, 24 1291-1306 (2005) [C1]
DOI 10.1002/sim.2010
Citations Scopus - 335Web of Science - 317
Co-authors Catherine Deste
2005 Chiarelli PE, Bower W, Wilson AJ, Attia JR, Sibbritt DW, 'Estimating the prevalence of urinary and faecal incontinence in Australia: systematic review', Australasian Journal on Ageing, 24 19-27 (2005) [C1]
DOI 10.1111/j.1741-6612.2005.00063.x
Citations Scopus - 14Web of Science - 9
Co-authors Amanda Wilson, Pauline Chiarelli
2004 Xu L, McElduff P, D'Este CA, Attia JR, 'Does dietary calcium have a protective effect on bone fractures in women? A meta-analysis of observational studies', The British Journal of Nutrition, 91 625-634 (2004) [C1]
DOI 10.1079/BJN20031085
Citations Scopus - 24Web of Science - 18
Co-authors Catherine Deste
2004 Attia JR, Nair BR, Mears SR, Hitchcock K, 'Patient-oxygen dissociation curves: surveying the spectrum of oxygen-delivery methods', MJA, 181 677-678 (2004) [C1]
Citations Scopus - 4Web of Science - 3
2004 Attia JR, Nair BR, Sibbritt DW, Ewald BD, Paget NS, Wellard RF, et al., 'Generating pre-test probabilities: a neglected area in clinical decision making', Medical Journal of Australia, 180 449-454 (2004) [C1]
Citations Scopus - 27Web of Science - 17
Co-authors Ben Ewald
2004 Zhang X, Attia JR, D'Este CA, Yu X, 'Prevalence and Magnitude of Classical Risk Factors for Stroke in a Cohort of 5092 Chinese Steelworkers Over 13.5 Years of Follow-up', Stroke, 35 1052-1056 (2004) [C1]
DOI 10.1161/01.STR.0000125305.12859.ff
Citations Scopus - 34Web of Science - 26
Co-authors Catherine Deste
2004 Rodsutti J, Hensley M, Thakkinstian A, D'Este C, Attia J, 'A clinical decision rule to prioritize polysomnography in patients with suspected sleep apnea', SLEEP, 27 694-699 (2004) [C1]
Citations Scopus - 18Web of Science - 17
Co-authors Catherine Deste
2004 Kelly H, Attia JR, Andrews R, Heller RF, 'The number needed to vaccinate (NNV) and population extensions of the NNV: comparison of influenza and pneumococcal vaccine programmes for people aged 65 years and over', Vaccine, 22 2192-2198 (2004) [C1]
DOI 10.1016/j.vaccine.2003.11.052
Citations Scopus - 43Web of Science - 33
2004 Ewald BD, Attia JR, 'Which test to detect microalbuminuria in diabetic patients?', Australian Family Physician, 33 565-568 (2004) [C1]
Citations Scopus - 17
Co-authors Ben Ewald
2004 Attia JR, Dudding TE, Infante-Rivard C, 'Addendum to: The association between adverse pregnancy outcomes and maternal factor V Leiden genotype: A meta-analysis', Thrombosis and Haemostasis, 92 434 (2004) [C3]
Citations Scopus - 2
Co-authors Tracy Dudding
2004 Thakkinstian A, D'Este CA, Eisman J, Nguyen T, Attia JR, 'Meta-Analysis of Molecular Association Studies: Vitamin D Receptor Gene Polymorphisms and BMD as a Case Study', Journal of Bone & Mineral Research, 19 419 (2004) [C1]
DOI 10.1359/JBMR.0301265
Citations Scopus - 152Web of Science - 120
Co-authors Catherine Deste
2004 Thakkinstian A, D'Este CA, Attia JR, 'Haplotype analysis of VDR gene polymorphisms: a meta-analysis', Osteoporosis International: with other metabolic bone diseases, 15 729-734 (2004) [C1]
DOI 10.1007/s00198-004-1601-x
Citations Scopus - 50Web of Science - 40
Co-authors Catherine Deste
2004 Attia JR, D'Este CA, Levi CR, 'The progress trial three years later. HOPE trial may shed some light', BMJ, 329 1403-1404 (2004) [C1]
DOI 10.1136/bmj.329.7479.1403-d
Co-authors Catherine Deste, Chris Levi
2004 Attia J, Eikelboom JW, Chunilal SD, Ginsberg JS, Mehra MR, 'Review: Clinical gestalt strategies and clinical prediction rules have similar discriminate pretest probabilities of pulmonary embolism', Evidence-Based Medicine, 9 155 (2004)
DOI 10.1136/ebm.9.5.155
2004 Dudding TE, Attia JR, 'The association between adverse pregnancy outcomes and maternal factor V Leiden genotype: a meta-analysis', Journal of Thrombosis and Haemostasis, 91 700-711 (2004) [C2]
Citations Scopus - 98Web of Science - 76
Co-authors Tracy Dudding
2004 Scott R, Crooks R, Rose L, Attia JR, Thakkinstian A, Thomas L, et al., 'Germline Missense Changes in the APC Gene and Their Relationship to Disease', Hereditary Cancer in Clinical Practice, 2 81-91 (2004) [C1]
DOI 10.1186/1897-4287-2-2-81
Co-authors Rodney Scott
2004 Xf Z, Attia JR, D'Este CA, Yu X, Wu X, 'Prevalence and magnitude of classical risk factors for coronary heart disease in a cohort of 4400 Chinese steelworkers over 13.5 years' follow-up', European Journal of Cardiovascular Prevention & Rehabilitation, 11 113-120 (2004) [C1]
DOI 10.1097/01.hjr.0000125480.31039.37
Citations Scopus - 16Web of Science - 15
Co-authors Catherine Deste
2004 Attia JR, 'Statistics with common sense', Australian Prescriber, 27 66-66 (2004)
2003 Page J, Attia JR, 'Using Bayes nomogram to help interpret odds ratios', EBM Online Evidence-based Medicine, 8 132-134 (2003) [C2]
Citations Scopus - 6
2003 Chiarelli PE, Bower W, Wilson AJ, Sibbritt DW, Attia JR, 'The prevalence of urinary incontinence in the community: a systematic review', Commonwealth Department of Health and Aged Care, (2003) [C3]
Co-authors Pauline Chiarelli, Amanda Wilson
2003 Chiarelli PE, Bower W, Wilson AJ, Sibbritt DW, Attia JR, 'The prevalence of faecal incontinence: a systematic review', Commonwealth Department of Health and Aged Care, (2003) [C3]
Co-authors Pauline Chiarelli, Amanda Wilson
2003 Nair BR, Attia JR, Bowe SJ, Mears SR, Hitchcock K, 'Interns are from Venus, consultants are from Mars: differential perception among clinicians', Medical Journal of Australia, 179 659-661 (2003) [C1]
2003 Wang Y, Levi CR, Attia JR, D'Este CA, Spratt N, Fisher JD, 'Seasonal Variation in Stroke in the Hunter Region, Australia: A 5-Year Hospital-Based Study, 1995-2000', Stroke: a journal of cerebral circulation, 34 1144-1150 (2003) [C1]
DOI 10.1161/01.STR.0000067703.71251.B6
Citations Scopus - 69Web of Science - 58
Co-authors Catherine Deste, Neil Spratt, Chris Levi
2003 Chunilal S, Eikelboom JW, Attia JR, Miniati M, Panju A, Simel DL, Ginsberg JS, 'Does this Patient Have Pulmonary Embolism?', JAMA, 290 2849-2858 (2003) [C1]
DOI 10.1001/jama.290.21.2849
Citations Scopus - 115Web of Science - 87
2003 Edwards MJ, Agho KE, Attia JR, Diaz P, Hayes T, Illingworth A, Roddick LG, 'Case-Control Study of Cleft Lip or Palate After Maternal Use of Topical Corticosteroids During Pregnancy', American Journal of Medical Genetics, 120 459-463 (2003) [C1]
DOI 10.1002/ajmg.a.20130
Citations Scopus - 43Web of Science - 37
2003 Attia J, 'Moving beyond sensitivity and specificity: Using likelihood ratios to help interpret diagnostic tests', Australian Prescriber, 26 111-113 (2003)

Properties of diagnostic tests have traditionally been described using sensitivity, specificity, and positive and negative predictive values. These measures, however, reflect popu... [more]

Properties of diagnostic tests have traditionally been described using sensitivity, specificity, and positive and negative predictive values. These measures, however, reflect population characteristics and do not easily translate to individual patients. Likelihood ratios are a more practical way of making sense of diagnostic test results and have immediate clinical relevance. In general a useful test provides a high positive likelihood ratio and a small negative likelihood ratio.

Citations Scopus - 64
2003 Attia JR, Thakkinstian A, D'Este CA, 'Meta-analyses of molecular association studies: Methodologic lessons for genetic epidemiology', The Journal of Clinical Epidemiology, 297-303 (2003) [C1]
DOI 10.1016/S0895-4356(03)00011-8
Citations Scopus - 226Web of Science - 205
Co-authors Catherine Deste
2003 Attia J, Nair K, Price JM, Jacobs A, 'On abandoning ties and avoiding nose rings [7]', British Medical Journal, 327 345 (2003)
Citations Scopus - 1
2003 Wang Y, Levi CR, D'Este CA, Attia JR, Fisher JD, 'Variation of Stroke Attack Rates in Rural, Urban, and Coalfields Areas of the Hunter Region, Australia 1995-2000', Journal of Stroke & Cerebrovascular Diseases, 12 103-110 (2003) [C1]
DOI 10.1053/jscd.2003.12
Citations Scopus - 3
Co-authors Chris Levi, Catherine Deste
2002 Nair BR, Attia JR, Mears S, Hitchcock K, 'Evidence-based physicians' dressing: a crossover trial', Medical Journal of Australia, 177(2) 681-682 (2002) [C1]
Citations Scopus - 16Web of Science - 14
2002 Attia JR, Page J, Heller R, Dobson A, 'Impact numbers in health policy decisions', Journal of Epidemiology & Community Health, 56 600-605 (2002) [C1]
Citations Scopus - 17Web of Science - 9
2002 Heller R, Dobson A, Attia JR, Page J, 'Impact numbers: measures of risk factor impact on the whole population from case-control and cohort studies', Journal of Epidemiology & Community Health, 56 606-610 (2002) [C1]
Citations Scopus - 28Web of Science - 16
2002 McElduff P, Attia JR, Ewald BD, Cockburn JD, Heller R, 'Estimating the contribution of individual risk factors to disease in a person with more than one risk factor', The Journal of Clinical Epidemiology, 55 588-592 (2002) [C1]
Citations Scopus - 15Web of Science - 13
Co-authors Ben Ewald
2001 Attia JR, Ray J, Cook D, Douketis J, Ginsberg J, Geerts W, 'Deep vein thrombosis and its prevention in critically ill adults', Archives of Internal medicine, 161 1268-1279 (2001) [C1]
Citations Scopus - 207Web of Science - 153
2001 Edmond K, Attia JR, D'Este CA, Condon J, 'Drowning and near-drowning in Northern Territory children', Medical Journal of Australia, 175 605-608 (2001) [C1]
Citations Scopus - 10Web of Science - 7
Co-authors Catherine Deste
2001 Attia J, Page J, 'A graphic framework for teaching critical appraisal of randomised controlled trials', Evidence-Based Medicine, 6 68-69 (2001)

Students of evidence-based medicine often try unsuccessfully to commit to memory a particular critical appraisal framework (often lengthy), or they have to depend on pocket cards ... [more]

Students of evidence-based medicine often try unsuccessfully to commit to memory a particular critical appraisal framework (often lengthy), or they have to depend on pocket cards and are lost without them. We have described a pedagogic aid: a flow diagram of an RCT, which has been developed over years of teaching residents. This diagram focuses on the steps in an RCT, and by drawing arrows, it highlights the biases possible at each step. This diagram serves as a framework on which the list of critical appraisal questions can be hung and is easy to remember.

DOI 10.1136/ebm.6.3.68
Citations Scopus - 2
2001 Attia JR, Page J, 'Editorial: A graphic framework for teaching critical appraisal of randomzied controlled trials', Internal Medicine Journal, 134 A11-A12 (2001) [C2]
2000 Cook D, Attia JR, Weaver B, McDonald E, Meade M, Crowther M, 'Venous Thromboembolic Disease: An Observational Study in Medical-Surgical Intensive Care Unit Patients', Journal of Critical Care, 15 127-132 (2000) [C1]
Citations Scopus - 70Web of Science - 51
2000 Attia J, Margetts P, Guyatt G, 'Review: Sensitive thyrotropin testing in unselected inpatients has low diagnostic accuracy. Commentary', Evidence-Based Medicine, 5 29 (2000)
DOI 10.1136/ebm.5.1.29
Citations Scopus - 1
2000 Attia J, Hatala R, Cook DJ, Wong JG, 'Review: The physical examination can exclude the diagnosis of meningitis in low-risk adults. Commentary', Evidence-Based Medicine, 5 28 (2000)
DOI 10.1136/ebm.5.1.28
Citations Scopus - 1
1999 Attia J, Margetts P, Guyatt G, 'Diagnosis of thyroid disease in hospitalized patients - A systematic review', ARCHIVES OF INTERNAL MEDICINE, 159 658-665 (1999)
DOI 10.1001/archinte.159.7.658
Citations Scopus - 60Web of Science - 41
1999 Attia J, Hatala R, Cook DJ, Wong JG, 'Does this adult patient have acute meningitis?', JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 282 175-181 (1999)
DOI 10.1001/jama.282.2.175
Citations Scopus - 137Web of Science - 93
1999 Douketis JD, Feightner JW, Attia J, Feldman WF, 'Periodic health examination, 1999 update: 1. Detection, prevention and treatment of obesity', CANADIAN MEDICAL ASSOCIATION JOURNAL, 160 513-525 (1999)
Citations Scopus - 133Web of Science - 102
1998 Attia J, Cook DJ, 'Prognosis in anoxic and traumatic coma', CRITICAL CARE CLINICS, 14 497-+ (1998)
DOI 10.1016/S0749-0704(05)70013-0
Citations Web of Science - 32
1998 Attia JR, Cook D, 'Indicators of poor neurologic prognosis in patients comatose due to intracranial bleeds and trauma: a systematic review and critical appraisal of the evidence.', Clinical Intensive Care, 9 129-133 (1998)
1996 Attia JR, Cook D, 'Indicators of poor neurological prognosis in patients with anoxic coma: a systematic review and critical appraisal of the evidence.', Clinical Intensive Care, 7 244-247 (1996)
1995 Attia J, Gupta S, Dunn RJ, 'Expression and secretion of a soluble form of myelin-associated glycoprotein (MAG).', Methods in molecular biology (Clifton, N.J.), 39 363-384 (1995)
1993 ATTIA J, HICKS L, OIKAWA K, KAY CM, DUNN RJ, 'STRUCTURAL-PROPERTIES OF THE MYELIN-ASSOCIATED GLYCOPROTEIN ECTODOMAIN', JOURNAL OF NEUROCHEMISTRY, 61 718-726 (1993)
Citations Scopus - 8Web of Science - 8
1989 ATTIA J, TROPAK M, JOHNSON PW, NEWERLYABRANOW W, PAWSON T, RODER JC, DUNN RJ, 'MODULATED ADHESION - A PROPOSAL FOR THE ROLE OF MYELIN-ASSOCIATED GLYCOPROTEIN IN MYELIN WRAPPING', CLINICAL CHEMISTRY, 35 717-720 (1989)
Citations Web of Science - 11
1989 JOHNSON PW, ATTIA J, RICHARDSON CD, RODER JC, DUNN RJ, 'SYNTHESIS OF SOLUBLE MYELIN-ASSOCIATED GLYCOPROTEIN IN INSECT AND MAMMALIAN-CELLS', GENE, 77 287-296 (1989)
DOI 10.1016/0378-1119(89)90076-0
Citations Web of Science - 12
1987 Fitt PS, Sharma N, Attia J, Korecky B, 'Studies of adenosine incorporation in Langendorff rat heart and rat heart mitochondria', Molecular and Cellular Biochemistry: an international journal for chemical biology in health and disease, 78 37-46 (1987)
Show 406 more journal articles

Review (1 outputs)

Year Citation Altmetrics Link
2004 Attia JR, 'Statistics with common sense', Australian Prescriber (2004) [D2]

Conference (79 outputs)

Year Citation Altmetrics Link
2016 Biswas M, Daneshi N, Dias T, Rasiah R, Mate K, Holliday E, et al., 'Prevalence of drug and gene interactions for cardiovascular drugs in older Australians' (2016)
Co-authors Karen Kerr, Liz Milward
2015 Daneshi N, Graham M, Holliday E, Schneider J, Kerr KP, Rasiah R, et al., 'Clinically actionable pharmacogenomic variants in community-dwelling older Australians.', ASMR XXIII NSW Scientific Meeting: Programme and Abstracts (2015)
Co-authors Liz Milward, Karen Kerr
2015 Harris ML, Oldmeadow C, Hure A, Loxton D, Luu J, Attia J, 'Increased risk of type 2 diabetes in women: does perceived stress hold the key?' (2015) [O1]
Co-authors Alexis Hure, Melissa Harris
2015 Biswas M, Daneshi N, Rasiah R, Mate K, Holliday E, Attia J, et al., 'Prevalence of cytochrome P450 (CYP) substrate-inhibitor interactions in patients on clopidogrel and frequency of CYP2C19*2 gene variants', Australasian Pharmaceutical Science Association (APSA)- Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) Joint Scientific Meeting. Book of Poster Abstracts (2015) [E3]
Co-authors Rohan Rasiah, Liz Holliday, Karen Kerr, Liz Milward, Karen Mate
2015 Sarwar G, Attia J, Bisquera A, 'NEUTRAL EFFECT OF INHALED CORTICOSTEROIDS ON BONE MINERAL DENSITY', RESPIROLOGY (2015) [E3]
2015 Bhaskar S, Bivard A, Parsons M, Nilsson M, Attia J, Stanwell P, Levi C, 'Delay of late-venous phase cortical vein filling in acute ischemic stroke patients' (2015) [E3]
Co-authors Chris Levi, Peter Stanwell, Mark Parsons
2015 Pundavela J, Roselli S, Demont Y, Faulkner S, Attia J, Keene S, et al., 'The neuronal protein sortilin is expressed in aggressive breast cancers and participates in tumor cell growth and invasion', CANCER RESEARCH (2015) [E3]
DOI 10.1158/1538-7445.SABCS14-P6-01-11
Co-authors Hubert Hondermarck, Marjorie Walker
2015 Faulkner S, Roselli S, Demont Y, Choquet G, Leissner P, Oldmeadow C, et al., 'ProNGF AS A NEW BIOMARKER IN THYROID CANCER', ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY (2015) [E3]
Co-authors Hubert Hondermarck, Christopher Oldmeadow, Marjorie Walker
2015 Makaroff AP, 'Seasonal variation in cervical arterial dissection in the Hunter New England region, New South Wales: a retrospective cohort study', Connect Physiotherapy Conference 2015: Conference Abstract E-book (2015) [E3]
Co-authors Chris Levi
2014 Denham JW, Joseph DJ, Lamb DS, Spry N, Duchesne GM, Matthews J, et al., 'Main oncologic endpoints of the TROG 03.04 (RADAR) Trial for men with locally advanced prostate cancer', JOURNAL OF CLINICAL ONCOLOGY (2014)
Citations Web of Science - 1
Co-authors Jim Denham, Allison Steigler
2014 Mather KA, Thalamuthu A, Oldmeadow C, Song F, Armstrong NJ, Poljak A, et al., 'Genome-wide significant results identified for plasma apolipoprotein h levels', Alzheimer's & Dementia (2014) [E3]
DOI 10.1016/j.jalz.2014.05.1526
Co-authors Mark Mcevoy, Rodney Scott, Christopher Oldmeadow, Liz Holliday, Peter Schofield
2014 Chouraki VA, Jakobsdottir J, Mather K, Adams H, Mollon J, Oldmeadow C, et al., 'A genome-wide meta-analysis of plasma clusterin levels in the charge consortium', Alzheimer's & Dementia (2014) [E3]
DOI 10.1016/j.jalz.2014.05.1159
Co-authors Christopher Oldmeadow, Rodney Scott, Liz Holliday
2014 Gunathilake R, Krishnamurthy V, Oldmedow C, Kerr E, Padmakumar C, Attia J, et al., 'Relationships between age, other predictive variables and the 90-day functional outcome after intravenous thrombolysis for acute ischemic stroke', INTERNATIONAL JOURNAL OF STROKE (2014) [E3]
Co-authors Mark Parsons, Christopher Oldmeadow, Chris Levi
2014 Kerr E, Sanson-Fisher RW, Paul CL, DEste C, Parsons M, Bladin C, et al., 'Thrombolysis ImPlementation in Stroke (TIPS): Evaluating the effectiveness of a strategy to increase the adoption of best evidence practice: An overview of data collected during the baseline period', INTERNATIONAL JOURNAL OF STROKE (2014) [E3]
Co-authors Chris Paul, Catherine Deste, Mark Parsons, Rob Sanson-Fisher, Frans Henskens, Chris Levi
2014 Bidarian-Moniri A, Nilsson M, Attia J, Ejnell H, 'Prone positioning for treatment of obstructive sleep apnoea', JOURNAL OF SLEEP RESEARCH (2014) [E3]
2014 Bolton KA, Holliday EG, McEvoy M, Attia J, Proietto A, Otton G, et al., 'A highly polymorphic AG repeat in the upstream regulatory region of the estrogen gene EIG121 is a potential modifier of endometrial cancer risk.', Asia-Pacific Journal of Clinical Oncology (2014) [E3]
DOI 10.1111/ajco.12335
Co-authors Liz Holliday, Mark Mcevoy, Rodney Scott, Kelly Kiejda, Nikola Bowden
2014 Lai J, Hure A, McEvoy M, Byles J, Attia J, 'Diet Quality And Depressive Symptoms In Mid-age Australian Women: Results From Preliminary Analysis', International Society for Affective Disorders Oral Abstract Book (2014) [E3]
Co-authors Mark Mcevoy, Alexis Hure, Julie Byles
2013 Lai JS, Hiles S, Hure AJ, McEvoy M, Attia J, 'SYSTEMATIC REVIEW AND META-ANALYSIS OF DIETARY PATTERNS AND DEPRESSION: OBSERVATIONAL STUDIES', ANNALS OF NUTRITION AND METABOLISM (2013) [E3]
Co-authors Mark Mcevoy, Alexis Hure
2013 Collins N, Kodur S, Ahmad W, Barker D, Davies A, Attia J, 'Influence of Age on Outcome in Treatment of Pulmonary Arterial Hypertension', Heart, Lung and Circulation (2013) [E3]
DOI 10.1016/j.hlc.2013.05.190
2013 Thomas J, Parsons O, Traylor M, Li L, Bevan S, Sudlow C, et al., 'The impact of CCS and TOAST classification systems on genetic associations with ischaemic stroke', INTERNATIONAL JOURNAL OF STROKE (2013) [E3]
Co-authors Chris Levi, Liz Holliday
2013 Dickson A, White J, Magin P, Attia J, Sturm J, Carter G, et al., 'Exploring the experience of psychological morbidity and service access in community dwelling stroke survivors: A qualitative follow up study', INTERNATIONAL JOURNAL OF STROKE (2013) [E3]
Citations Scopus - 2
Co-authors Parker Magin, Gregory Carter
2013 Nyholt DR, Low S-K, Anderson CA, Painter JN, Uno S, Morris AP, et al., 'Meta-Analysis of GWA Studies Identifies New Endometriosis Risk Loci', REPRODUCTIVE SCIENCES (2013) [E3]
Co-authors Rodney Scott, Liz Holliday, Mark Mcevoy
2012 White JH, Magin PJ, Attia JR, Sturm J, Carter GL, McElduff P, Pollack MR, 'Trajectories of psychological distress: A longitudinal cohort study', Neurorehabilitation & Neural Repair: WCNR 2012 Oral Abstracts (2012) [E3]
Co-authors Parker Magin, Gregory Carter
2012 White JH, Magin PJ, Attia JR, Sturm J, Carter GL, McElduff P, Pollack MR, 'Exploring post stroke changes in community dwelling stroke survivors: A mixed methods longitudinal cohort study', Neurorehabilitation & Neural Repair: WCNR 2012 Oral Abstracts (2012) [E3]
Co-authors Parker Magin, Gregory Carter
2012 Islam MR, Khan I, Hassan SMN, McEvoy MA, D'Este CA, Attia JR, et al., 'Association between hypertension and chronic exposure in Bangladesh', Hypertension (2012) [E3]
Co-authors Mark Mcevoy, Milton Hasnat, Catherine Deste
2012 Minelli C, Gogele M, Thakkinstian A, Yurkiewich A, Pattaro C, Pramstaller PP, et al., 'Methods for meta-analyses of genome-wide association studies: Critical assessment of empirical evidence', Genetic Epidemiology (2012) [E3]
2012 Holliday S, Magin PJ, Dunbabin JS, Oldmeadow CJ, Henry J-M, Lintzeris N, et al., 'Motivating factors amongst NSW general practitioners regarding the prescription of opioid substitution therapy', Drug and Alcohol Review (2012) [E3]
Citations Web of Science - 1
Co-authors Adrian Dunlop, Christopher Oldmeadow, Parker Magin
2012 Ewald BD, McElduff P, Attia JR, 'How many steps are enough? Dose response curves for objectively measured physical activity in an Australian community based sample', Journal of Science and Medicine in Sport (2012) [E3]
Co-authors Ben Ewald
2012 Talseth-Palmer B, Holliday EG, Evans T-J, McEvoy MA, Attia JR, Grice DM, et al., 'A genome-wide CNV association study of Australian HNPCC/Lynch syndrome patients', Proceedings of the Australian Health & Medical Research Congress 2012 (2012) [E3]
Co-authors Bente Talseth-Palmer, Mark Mcevoy, Liz Holliday, Rodney Scott
2012 Ranasinghe WKB, Attia JR, Oldmeadow CJ, Lawrentschuk N, Robertson J, Ranasinghe T, et al., 'Bladder carcinoma in situ in Australia: A rising incidence for an under-reported malignancy', Asia-Pacific Journal of Clinical Oncology (2012) [E3]
Citations Scopus - 1
Co-authors Christopher Oldmeadow
2011 Courtney RJ, Paul CL, Sanson-Fisher RW, Macrae FA, Carey ML, Attia JR, McEvoy MA, 'Colorectal cancer screening in Australia: A community-level perspective', Asia-Pacific Journal of Clinical Oncology: COSA 38th Annual Scientific Meeting Poster Abstracts (2011) [E3]
DOI 10.5694/mja11.10661
Co-authors Mariko Carey, Chris Paul, Mark Mcevoy, Rob Sanson-Fisher
2011 Maguire JM, Holliday EG, Sturm J, Golledge J, Lewis M, Koblar S, et al., 'Australian stroke genetics collaborative: Genetic associations with ischaemic stroke functional outcome', International Journal of Stroke (2011) [E3]
Co-authors Pablo Moscato, Lisa Lincz, Liz Holliday, Rodney Scott, Mark Parsons, Chris Levi, Jane Maguire
2011 White JH, Magin PJ, Attia JR, Sturm J, Carter GL, Fitzgerald MN, et al., 'Post-stroke depression and anxiety: A longitudinal cohort study', Journal of Neurology (2011) [E3]
Co-authors Gregory Carter, Parker Magin
2011 Holliday S, Magin PJ, Dunlop AJ, Dunbabin JS, Henry J, Goode SM, et al., 'Opioid analgesics in chronic non-cancer pain: A quality use of medicines study', Drug and Alcohol Review (2011) [E3]
Co-authors Adrian Dunlop, Parker Magin
2011 White JH, Magin PJ, Attia JR, Sturm J, Carter GL, Fitzgerald MN, et al., 'Post-stroke depression and anxiety: A longitudinal cohort study', Cerebrovascular Diseases (2011) [E3]
Co-authors Parker Magin, Gregory Carter
2011 Russell ML, Evans MK, Royan AT, Magin PJ, Lasserson D, Attia JR, et al., 'Referral and triage of patients with TIAs to an acute access clinic: Risk-stratification performance in an Australian setting', International Journal of Stroke (2011) [E3]
Co-authors Neil Spratt, Parker Magin, Chris Levi, Mark Parsons
2011 White JH, Magin PJ, Attia JR, Sturm J, Carter GL, Pollack MR, 'Trajectories of psychological distress after stroke: A longitudinal, mixed methods cohort study', Stroke Society of Australasia Annual Scientific Meeting 2011 (SSA-ASM) (2011) [E3]
Co-authors Gregory Carter, Parker Magin
2011 Thomas L, Rivett DA, Levi CR, 'Risk factors and clinical presentation of craniocervical arterial dissection. A prospective study: Preliminary results', Physiotherapy: Abstracts, World Physical Therapy 2011 (2011) [E3]
Citations Scopus - 9Web of Science - 8
Co-authors Darren Rivett, Chris Levi, Lucy Thomas
2011 Khan I, Hassan S, McEvoy MA, D'Este CA, Attia JR, Peel R, Hasnat MA, 'Association between type 2 diabetes and chronic arsenic exposure in Bangladesh', Epidemiology (2011) [E3]
Citations Web of Science - 2
Co-authors Mark Mcevoy, Milton Hasnat, Catherine Deste, Roseanne Peel
2011 Nickel J, Attia JR, Anothaisintawee T, Thakkinstian A, 'a-blockers, antibiotics and anti-inflammatories have a role in management of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS)', Urology (2011) [E3]
2011 Allen J, Inder KJ, Kelly BJ, Attia JR, Lewin TJ, 'An interaction of social support and remoteness in the prediction of psychological distress', Journal of Epidemiology and Community Health (2011) [E3]
Co-authors Brian Kelly, Kerry Inder, Terry Lewin
2011 Ambikaipaker V, Mathew A, Attia JR, 'Serum tumour markers: a retrospective analysis. A guide in using serum tumour markers in predicting malignancy', Journal of Gastroenterology and Hepatology (2011) [E3]
2011 Holland R, Dunlop AJ, Hinman J, Ribbons K, Sadler CW, Gill AJ, et al., 'Buprenorphine-naloxone vs wait list control RCT: Health service utilisation and health economic outcomes', Drug and Alcohol Review (2011) [E3]
Co-authors Adrian Dunlop
2011 Gupta S, Lewis G, Rogers K, Attia J, 'QUANTITATIVE RENAL TRANSPLANT SCINTIGRAPHY: PATHOLOGICAL CORRELATION (ANZAPNM Award Entry)', INTERNAL MEDICINE JOURNAL (2011) [E3]
2010 Murphy VE, Namazy JA, Powell GH, Gibson PG, Chambers C, Attia JR, Schatz M, 'A meta-analysis of adverse perinatal outcomes in asthmatic women: Effect of asthma on placental and neonatal outcomes', American Journal of Respiratory and Critical Care Medicine (2010) [E3]
Co-authors Vanessa Murphy, Peter Gibson
2010 White JH, Magin PJ, Attia JR, Sturm J, Pollack MR, 'Exploring goal setting in stroke survivors: a prospective study', Cerebrovascular Diseases: European Stroke Conference (2010) [E3]
Co-authors Parker Magin
2010 White JH, Magin PJ, Attia JR, Sturm J, McElduff P, Pollack MR, 'Exploring post-stroke mood changes in community-dwelling stroke survivors: a prospective qualitative study', Cerebrovascular Diseases: European Stroke Conference (2010) [E3]
Co-authors Parker Magin
2010 White JH, Magin PJ, Attia JR, Sturm J, McElduff P, Pollack MR, 'Exploring post-stroke mood changes in community-dwelling stroke survivors: a longitudinal cohort study', Cerebrovascular Diseases: European Stroke Conference (2010) [E3]
Co-authors Parker Magin
2010 White J, Miller B, Magin PJ, Attia JR, Sturm J, 'Access and participation in the community: A prospective cohort qualitative study of driving post-stroke', Cerebrovascular Diseases: European Stroke Conference (2010) [E3]
Co-authors Parker Magin
2010 Miles S, Rogers K, Thomas P, Allen L, Soans B, Abel C, et al., 'Comparing the reliability of reporting of single photon emission computed tomography ventilation-perfusion scintigraphy (SPECT-VQ) and CT pulmonary angiogram (CTPA) in pulmonary embolism (PE) diagnosis', European Respiratory Society Annual Congress 2010. Abstracts (2010) [E3]
Co-authors Michael Hensley, Catherine Deste
2010 Maguire JM, Thakkinstian A, Levi CR, Lincz L, Bissett KE, Sturm J, et al., 'Genetic influences on ischemic stroke 90-day functional outcome: A novel association', Circulation (2010) [E3]
Co-authors Jane Maguire, Lisa Lincz, Rodney Scott, Chris Levi
2010 Hiles SA, Attia JR, Baker AL, 'Changes in interleukin-6, C-reactive protein and interleukin-10 in people with depression following antidepressant treatment: A meta-analysis', Brain, Behavior, and Immunity (2010) [E3]
Co-authors Amanda Baker
2010 Hiles SA, Attia JR, Baker AL, 'Interleukin-6 in people with and without depression: Exploring moderators using meta-analytic techniques', Brain, Behavior, and Immunity (2010) [E3]
Co-authors Amanda Baker
2010 Dunlop A, Lintzeris N, Gill T, Sadler C, Ribbons K, Attia J, et al., 'EFFECTIVENESS AND COST EFFECTIVENESS OF UNSUPERVISED BUPRENORPHINE-NALOXONE VERSUS WAIT LIST CONTROL RCT', DRUG AND ALCOHOL REVIEW (2010) [E3]
Co-authors Adrian Dunlop
2010 Murphy VE, Namazy J, Powell GH, Gibson PG, Chambers C, Attia JR, Schatz M, 'A meta-analysis of adverse perinatal outcomes in asthmatic women: Effect of asthma on maternal and neonatal outcomes', Respirology (2010) [E3]
Co-authors Vanessa Murphy, Peter Gibson
2010 Murphy VE, Namazy J, Powell GH, Schatz M, Chambers C, Attia JR, Gibson PG, 'A meta-analysis of adverse perinatal outcomes in asthmatic women: Effect of asthma on size at birth and timing of birth', Respirology (2010) [E3]
Co-authors Vanessa Murphy, Peter Gibson
2010 Talseth-Palmer B, Holliday EG, Evans T-J, McPhillips M, McEvoy MA, Attia JR, Scott R, 'A modern approach to the search for modifying genetic loci infleuncing the high breast cancer incidence seen in an Australian HNPCC/Lynch Syndrome cohort', Proceedings of the Australian Health and Medical Research Congress 2010 (2010) [E3]
Co-authors Mark Mcevoy, Bente Talseth-Palmer, Liz Holliday, Rodney Scott
2010 Ranasinghe WKB, Wright T, Doyle TE, Attia JR, McElduff P, Persad R, 'Bariatric surgery: An added benefit for obese females with urinary incontinence?', BJU International (2010) [E3]
2009 Henry D, Lincz L, Attia JR, McElduff P, Bisset L, Peel R, et al., 'Polymorphisms in two regions of the cyclo-oxygenase-2 gene associated with variation in risk of coronary thrombosis with cyclo-oxygenase-2 inhibitors', Basic & Clinical Pharmacology & Toxicology (2009) [E3]
DOI 10.1111/j.1742-7843.2009.00436.x
Co-authors Lisa Lincz, Roseanne Peel
2009 Osmotherly PG, Attia JR, McElduff P, 'The composite neck pain and disability questionnaire: Development and factor structure', Australian Journal of Physiotherapy: eSupplements (2009) [E3]
Co-authors Peter Osmotherly
2009 Pickering PM, Osmotherly PG, Attia JR, McElduff P, 'An examination of outcome measures for pain and dysfunction in the cervical spine: A factor analysis', Australian Journal of Physiotherapy: eSupplements (2009) [E3]
Co-authors Peter Osmotherly
2009 Maguire J, Thakkinstian A, Attia JR, Lincz L, Bisset L, Sturm J, et al., 'Impact of COX-2 RS5275, RS20417 and GPIIIA RS5918 polymorphisms on 90 day ischaemic stroke functional outcome: A novel association', Cerebrovascular Diseases (2009) [E3]
DOI 10.1159/000221772
Co-authors Chris Levi, Lisa Lincz, Rodney Scott
2009 Jones LJ, Craven PD, Attia JR, Thakkinstian A, Wright IM, 'Administration of intravenous ibuprofen for significant PDA in preterm infants at greater than 24 h of life: Does it increase the risk of chronic lung disease (CLD)?', Journal of Paediatrics and Child Health (2009) [E3]
DOI 10.1111/j.1440-1754.2009.01475.x
Co-authors Ian Wright
2009 Henry D, Lincz L, Attia J, McElduff P, Bisset L, Peel R, et al., 'Polymorphisms in Two Regions of the Cyclo-Oxygenase-2 Gene Associated with Variation in Risk of Coronary Thrombosis with Cyclo-Oxygenase-2 Inhibitors', PHARMACOEPIDEMIOLOGY AND DRUG SAFETY (2009) [E3]
Co-authors Roseanne Peel, Lisa Lincz
2008 Jones LJ, Craven PD, Attia JR, Wright I, 'Early targeted indomethacin: Where is the evidence?', Journal of Paediatrics and Child Health (2008) [E3]
DOI 10.1111/j.1440-1754.2008.01297.x
2008 Miles S, Rogers K, Thomas P, Soans B, Attia JR, Abel C, et al., 'Lung single photon emission computed tomography (SPECT): A useful tool for diagnosing pulmonary embolism', Respirology (2008) [E3]
DOI 10.1111/j.1440-1843.2008.01252_9.x
Co-authors Michael Hensley, Catherine Deste
2008 Boggess MM, Guest M, D'Este CA, Attia JR, 'Statistical methods to compare hearing thresholds to ISO-7029', Occupational & Environmental Medicine (2008) [E3]
Co-authors Catherine Deste
2008 Guest M, D'Este CA, Attia JR, Boggess MM, 'Impairment of hearing and balance in aircraft maintenance technicians', Occupational & Environmental Medicine (2008) [E3]
Co-authors Catherine Deste
2008 White JH, Magin PJ, Pollack MR, Attia JR, Sturm J, 'The long-term experience of altered mood in community dwelling stroke survivors: Methodology and preliminary findings of a longitudinal qualitative study', 2008 General Practice & Primary Health Care Research Conference: Program & Abstracts (2008) [E3]
Co-authors Parker Magin
2008 Wood LG, Attia JR, McElduff P, McEvoy MA, Flood V, Gibson PG, 'Dietary fat and an activated innate immune response are associated with reduced FEV1', Asia Pacific Journal of Clinical Nutrition (2008) [E3]
Co-authors Peter Gibson, Mark Mcevoy, Lisa Wood
2008 Ashton KA, Proietto AM, Otton GR, Symonds IM, McEvoy MA, Attia JR, et al., 'Combined tp53 r72p and mdm2 snp309 genotypes are associated with high grade endometrial cancer', ASMR XVII NSW Scientific Meeting: Programme and Abstracts (2008) [E3]
Co-authors Rodney Scott, Ian Symonds, Mark Mcevoy
2008 Oakley PW, Nair BR, Attia JR, 'Teaching hospital based formative assessment can predict Trainee performance in RACP written examination', ANZAME Conference 2008. Conference Program, Abstracts and Papers (2008) [E3]
2007 Maguire J, Sturm J, Attia JR, Whyte S, Bisset L, Lincz L, et al., 'A case-control genetic association study to examine platelet glycoprotein polymorphisms and ischaemic stroke risk', Internal Medicine Journal (2007) [E3]
Co-authors Lisa Lincz, Mark Parsons, Chris Levi
2006 D'Este C, Attia J, Brown A, Schofield P, Tavener M, Gibson R, Horsley K, 'SHOAMP: The study of health outcomes in aircraft maintenance personnel.', NEUROTOXICOLOGY (2006)
Co-authors Peter Schofield, Meredith Tavener, Catherine Deste
2006 Ronan A, Thakkinstian A, Zakaria S, Settakorn J, Moscovis SM, Scott R, et al., 'The role of MTHFR polymorphisms and dietary folate in childhood cancer', Program of the 11th International Congress of Human Genetics (2006) [E3]
Co-authors Rodney Scott
2005 Guest M, Wigney DJ, Attia JR, D'Este CA, Brown A, Boggess M, 'Hearing Loss in Australian Military Aircraft Personnel', AIOH : 23rd Annual Conference of the Australian Institute of Occupational Hygienists & Annual General Meeting : conference proceedings : 3rd to 7th December 2005, Crowne Plaza, Terrigal, N.S.W (2005) [E2]
Co-authors Catherine Deste
2003 Osmotherly PG, Attia JR, 'Deep cervical flexor muscle performance and neck pain in call centre operators - a pilot study', Musculoskeletal Physiotherapy Australia 13th Biennial Conference (2003) [E3]
Co-authors Peter Osmotherly
2003 Wang Y, Levi CR, D'Este CA, Attia JR, Spratt N, Fisher J, 'Seasonal variation in stroke in the Hunter Region, Australia a five-year hospital-based study, 1995-2000', STROKE (2003)
Co-authors Catherine Deste, Neil Spratt, Chris Levi
2003 Thakkinstian A, D'Este C, Eisman J, Nguyen T, Attia J, 'Meta-analysis of molecular association studies: The vitamin D receptor gene polymorphisms and bone mineral density as a case study.', JOURNAL OF BONE AND MINERAL RESEARCH (2003)
Co-authors Catherine Deste
Show 76 more conferences

Report (6 outputs)

Year Citation Altmetrics Link
2014 Gwynn JD, Blunden SV, Turner N, Flood V, Attia J, Smith W, et al., 'Many Rivers Diabetes Prevention Project: An Aboriginal community governed program of research and health promotion for children. Final Report August 2014', NSW MInistry of Health (2014) [R1]
Co-authors Josephine Gwynn, Wayne Smith, John Wiggers, Catherine Deste
2014 Gwynn JD, Blunden SV, Turner N, Flood V, Attia J, Smith W, et al., 'Many Rivers Diabetes Prevention Project: An Aboriginal community governed program of research and health promotion for children. Short Report.', NSW MInistry of Health, 27 (2014) [R1]
Co-authors Wayne Smith, Josephine Gwynn, John Wiggers, Catherine Deste
2004 D'Este C, Attia J, Byles JE, Brown A, Smith S, Tavener MA, Scientific Advisory Committee, 'Study of Health Outcomes in Aircraft Maintenance Personnel. Volume 4. Mortality and Cancer Incidence Study. Second Report.', Department of Defence and Department of Veterans' Affairs, 155 (2004)
Co-authors Julie Byles, Meredith Tavener, Catherine Deste
2004 D'Este C, Byles JE, Attia J, Brown A, Smith S, Tavener MA, Scientific Advisory Committee, 'Study of Health Outcomes in Aircraft Maintenance Personnel. Volume 2. Mortality and Cancer Incidence Study. Interim Report.', Department of Defence and Department of Veterans' Affairs, 105 (2004)
Co-authors Meredith Tavener, Catherine Deste, Julie Byles
2003 Byles J, D'Este C, Attia J, Brown A, Tavener MA, Smith S, Scientific Advisory Committee members, 'Study of Health Outcomes in Aircraft Maintenance Personnel. Volume 1. Literature Review. Final Report.', Department of Defence and Department of Veterans' Affairs, 148 (2003)
Co-authors Julie Byles, Catherine Deste
2003 Adams J, Milne L, Tavener MA, Byles JE, D'Este C, Attia J, et al., 'Study of Health Outcomes in Aircraft Maintenance Personnel. Volume 3. Qualitative Interviews. Final Report.', Department of Defence and Department of Veterans' Affairs, 88 (2003)
Co-authors Meredith Tavener, Catherine Deste
Show 3 more reports
Edit

Grants and Funding

Summary

Number of grants 74
Total funding $15,002,260

Click on a grant title below to expand the full details for that specific grant.


20162 grants / $386,612

The role of adjuvant zoledronic acid in locally advanced prostate cancer$376,612

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Jim Denham, Professor David Joseph, Professor G Duchesne, Professor John Attia
Scheme Project Grant
Role Investigator
Funding Start 2016
Funding Finish 2017
GNo G1500121
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

2016 International Visitor from University of Sheffield, UK$10,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor John Attia, Professor Michael Campbell
Scheme International Research Visiting Fellowship
Role Lead
Funding Start 2016
Funding Finish 2016
GNo G1500955
Type Of Funding Internal
Category INTE
UON Y

20155 grants / $2,086,020

Helping stroke physicians choose who to thrombolyse - the "Targeting Optimal Thrombolysis Outcomes" (TOTO) study$1,031,671

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Dr LIZ Holliday, Associate Professor Jane Maguire, Associate Professor Vincent Thijs, Dr Simon Koblar, Conjoint Associate Professor Jonathan Sturm, Professor John Attia, Doctor Lisa Lincz, Doctor Andrew Bivard
Scheme Project Grant
Role Investigator
Funding Start 2015
Funding Finish 2018
GNo G1400237
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

A practice change intervention to increase the provision of antenatal care addressing maternal alcohol consumption during pregnancy: a stepped-wedge trial$766,349

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor John Wiggers, Professor Elizabeth Elliott, Associate Professor Adrian Dunlop, Professor Ian Symonds, Professor John Attia, Doctor Luke Wolfenden, Professor Chris Rissel
Scheme Partnership Projects
Role Investigator
Funding Start 2015
Funding Finish 2019
GNo G1500584
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

A practice change intervention to increase the provision of antenatal care addressing maternal alcohol consumption during pregnancy: a stepped-wedge trial$168,000

Funding body: Hunter New England Local Health District

Funding body Hunter New England Local Health District
Project Team Professor John Wiggers, Professor Elizabeth Elliott, Associate Professor Adrian Dunlop, Professor Ian Symonds, Professor John Attia, Doctor Luke Wolfenden, Professor Chris Rissel
Scheme Partnership Projects Partner Funding
Role Investigator
Funding Start 2015
Funding Finish 2019
GNo G1500682
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

A practice change intervention to increase the provision of antenatal care addressing maternal alcohol consumption during pregnancy: a stepped-wedge trial$80,000

Funding body: NSW Office of Preventative Health

Funding body NSW Office of Preventative Health
Project Team Professor John Wiggers, Professor Elizabeth Elliott, Associate Professor Adrian Dunlop, Professor Ian Symonds, Professor John Attia, Doctor Luke Wolfenden, Professor Chris Rissel
Scheme Partnership Projects Partner Funding
Role Investigator
Funding Start 2015
Funding Finish 2019
GNo G1500683
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

A practice change intervention to increase the provision of antenatal care addressing maternal alcohol consumption during pregnancy: a stepped-wedge trial$40,000

Funding body: Foundation for Alcohol Research and Education

Funding body Foundation for Alcohol Research and Education
Project Team Professor John Wiggers, Professor Elizabeth Elliott, Associate Professor Adrian Dunlop, Professor Ian Symonds, Professor John Attia, Doctor Luke Wolfenden, Professor Chris Rissel
Scheme Partnership Projects Partner Funding
Role Investigator
Funding Start 2015
Funding Finish 2019
GNo G1500681
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

20148 grants / $3,012,639

Does pneumococcal vaccination protect against cardiovascular disease? $1,815,627

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor John Attia, Professor Catherine D'Este, Dr Walter Abhayaratna, Professor Andrew Tonkin, Conjoint Professor Chris Levi, Conjoint Professor David Durrheim, Professor Joseph Hung, Associate Professor Mark McEvoy, Doctor Alexis Hure
Scheme Project Grant
Role Lead
Funding Start 2014
Funding Finish 2018
GNo G1300127
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Reducing unnecessary ordering of pathology tests in hospitalised patients$372,927

Funding body: HCF Health and Medical Research Foundation

Funding body HCF Health and Medical Research Foundation
Project Team Professor John Attia, Conjoint Professor Christopher Doran, Caprf ANDREW Searles, Laureate Professor Robert Sanson-Fisher, Conjoint Professor Anne Duggan, Conjoint Associate Professor Huy Tran, Mr Nigel Lyons, Ms Tracy McCosker, Doctor Alexis Hure
Scheme Health Services Research Grants Program
Role Lead
Funding Start 2014
Funding Finish 2017
GNo G1301000
Type Of Funding Aust Competitive - Non Commonwealth
Category 1NS
UON Y

Reducing unnecessary ordering of pathology tests in hospitalised patients$372,927

Funding body: HCF Health and Medical Research Foundation

Funding body HCF Health and Medical Research Foundation
Project Team Professor John Attia, Conjoint Professor Christopher Doran, Caprf ANDREW Searles, Laureate Professor Robert Sanson-Fisher, Conjoint Professor Anne Duggan, Conjoint Associate Professor Huy Tran, Mr Nigel Lyons, Ms Tracy McCosker, Doctor Alexis Hure
Scheme Health Services Research Grants Program
Role Lead
Funding Start 2014
Funding Finish 2017
GNo G1301000
Type Of Funding Aust Competitive - Non Commonwealth
Category 1NS
UON Y

Evaluation of a tailored online hospital and post-discharge smoking cessation program for orthopaedic trauma surgery patients$364,658

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Billie Bonevski, Professor Zsolt Balogh, Professor Amanda Baker, Professor Ian Harris, Professor John Attia, Conjoint Professor Christopher Doran, Dr Johnson George, Doctor Luke Wolfenden
Scheme Partnership Projects
Role Investigator
Funding Start 2014
Funding Finish 2017
GNo G1300686
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Genetic and Environmental Determinants of Depressive Symptoms: Trajectory and Outcomes in a Longitudinal Population Data Set$30,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor Brian Kelly, Associate Professor Paul Tooney, Professor Rodney Scott, Professor John Attia, Conjoint Associate Professor Murray Cairns, Professor Vaughan Carr
Scheme Project Grant
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1400594
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Biological characterisation of genetic associations for large artery atherosclerotic stroke$25,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Dr LIZ Holliday, Professor Rodney Scott, Conjoint Professor Chris Levi, Professor John Attia, Associate Professor Jane Maguire
Scheme Stroke Research Project Grant
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1301340
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

The role of perceived stress on the onset of type 2 diabetes in women.$21,500

Funding body: John Hunter Hospital Charitable Trust

Funding body John Hunter Hospital Charitable Trust
Project Team Doctor Melissa Harris, Professor John Attia, Doctor Judy Luu, Associate Professor Deb Loxton
Scheme Research Grant
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1301440
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

A descriptive observational study of infants aged < 24 months with severe bronchiolitis requiring critical care$10,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Elizabeth Kepreotes, Professor Joerg Mattes, Doctor Peter Harrigan, Conjoint Associate Professor Bruce Whitehead, Professor John Attia, Doctor Mark Lee
Scheme Critical Care and HMRI BRICs Nursing Research and Innovation Grant
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1401451
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

20134 grants / $150,000

A genome wide association study on childhood brain tumours$115,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor Rodney Scott, Doctor Frank Alvaro, Miss TIFFANY Evans, Professor John Attia, Dr LIZ Holliday, Dr Elizabeth Milne, Professor Bruce Armstrong
Scheme Research Grant
Role Investigator
Funding Start 2013
Funding Finish 2015
GNo G1301149
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Hunter Community Study$15,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor John Attia
Scheme Project Grant
Role Lead
Funding Start 2013
Funding Finish 2015
GNo G1300200
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

The genetic determinants of brain haemorrhage associated with stroke thrombolysis$10,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Conjoint Professor Chris Levi, Professor John Attia, Dr LIZ Holliday, Dr Simon Koblar, Professor Rodney Scott, Conjoint Associate Professor Jonathan Sturm, Associate Professor Jonathan Rosand, Doctor Lisa Lincz, Associate Professor Jane Maguire
Scheme Near Miss Grant
Role Investigator
Funding Start 2013
Funding Finish 2013
GNo G1300475
Type Of Funding Internal
Category INTE
UON Y

The genetic determinants of brain haemorrhage associated with stroke thrombolysis$10,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Conjoint Professor Chris Levi, Professor John Attia, Dr LIZ Holliday, Dr Simon Koblar, Professor Rodney Scott, Conjoint Associate Professor Jonathan Sturm, Associate Professor Jonathan Rosand, Doctor Lisa Lincz, Associate Professor Jane Maguire
Scheme Near Miss
Role Investigator
Funding Start 2013
Funding Finish 2013
GNo G1300704
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

20125 grants / $1,161,118

An olfactory 'stress test' for early detection of Alzheimer's disease$756,087

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Associate Professor Peter Schofield, Professor John Attia, Professor Alison Jones, Conjoint Associate Professor Grant Bateman
Scheme Project Grant
Role Investigator
Funding Start 2012
Funding Finish 2015
GNo G1100221
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Double blind randomised controlled trial of electronic alcohol screening and brief intervention (e-SBI) for hospital outpatients$359,031

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Kypros Kypri, Doctor Natalie Johnson, Professor John Saunders, Professor Richard Saitz, Professor John Attia
Scheme Project Grant
Role Investigator
Funding Start 2012
Funding Finish 2015
GNo G1100111
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Validation of the food frequency questionnaire used in the Hunter Community Study using carotenoids and fatty acids$25,000

Funding body: John Hunter Hospital Charitable Trust

Funding body John Hunter Hospital Charitable Trust
Project Team Doctor Alexis Hure, Professor John Attia, Associate Professor Mark McEvoy
Scheme Research Grant
Role Investigator
Funding Start 2012
Funding Finish 2012
GNo G1200266
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

The genetic determinants of brain haemorrhage associated with stroke thrombolysis$20,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Conjoint Professor Chris Levi, Professor John Attia, Dr LIZ Holliday, Professor Rodney Scott, Conjoint Associate Professor Jonathan Sturm, Doctor Lisa Lincz
Scheme Near Miss Grant
Role Investigator
Funding Start 2012
Funding Finish 2012
GNo G1200675
Type Of Funding Internal
Category INTE
UON Y

Plasma protein profiles in normal brain ageing and early stages of dementia$1,000

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Professor Perminder Sachdev, Dr Anne Poljak, Professor John Attia, Conjoint Associate Professor Peter Schofield, Dr John Crawford, Professor Mark Duncan
Scheme Discovery Projects
Role Lead
Funding Start 2012
Funding Finish 2014
GNo G1200767
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

20111 grants / $1,075,461

Implementation of quality use of advanced CT imaging in acute stroke$1,075,461

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Mark Parsons, Conjoint Professor Chris Levi, Professor Geoff Donnan, Professor Stephen Davis, Professor John Attia, Professor Christopher Bladin, Mr Qing Yang, Associate Professor Peter Mitchell, Associate Professor Stacy Goergen, Professor Ramamohanarao Kotagiri
Scheme Partnership Projects
Role Investigator
Funding Start 2011
Funding Finish 2015
GNo G1000535
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

201010 grants / $1,915,695

Evaluating the effectiveness of a strategy to increase the adoption of best evidence practice. A cluster randomised controlled trial in acute stroke care$772,950

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Laureate Professor Robert Sanson-Fisher, Conjoint Professor Chris Levi, Associate Professor Christine Paul, Conjoint Professor Cate d'Este, Professor Mark Parsons, Professor Christopher Bladin, Professor Richard Lindley, Professor John Attia
Scheme Partnership Projects
Role Investigator
Funding Start 2010
Funding Finish 2016
GNo G0189781
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Men, Depression and Social Networks in Rural Communities: Linking Epidemiologic Evidence to Effective Interventions$324,809

Funding body: Beyond Blue Ltd

Funding body Beyond Blue Ltd
Project Team Professor Brian Kelly, Professor John Attia, Doctor Frances Kay-Lambkin, Conjoint Associate Professor Terry Lewin, Professor Amanda Baker, Mr Trevor Hazell, Doctor Kerry Inder
Scheme Research Grant
Role Investigator
Funding Start 2010
Funding Finish 2012
GNo G1000456
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Xstrata Coal Fellow in Depression$300,000

Funding body: Xstrata Coal Australia Pty Ltd

Funding body Xstrata Coal Australia Pty Ltd
Project Team Professor Brian Kelly, Professor John Attia, Doctor Frances Kay-Lambkin, Conjoint Associate Professor Terry Lewin, Professor Amanda Baker, Mr Trevor Hazell, Doctor Kerry Inder
Scheme Xstrata Coal Fellow in Depression
Role Investigator
Funding Start 2010
Funding Finish 2012
GNo G0900102
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Genetic associations of early retinal pathologic phenotypes: Data pooling and meta-analyses of multiple populations$182,438

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Associate Professor Jie Wang, Professor Eric Boerwinkle, Dr Gerald Liew, Professor Pablo Moscato, Dr Shyong Tai, Dr Alexander Hewitt, Professor John Attia, Associate Professor Yik Teo, Professor Ronald Klein, Doctor Patrick McElduff
Scheme Project Grant
Role Lead
Funding Start 2010
Funding Finish 2012
GNo G1101153
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Experimental Studies of the Effects of the Research Process on Participant Behaviour$178,000

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Professor Kypros Kypri, Dr Jim McCambridge, Professor John Attia, Mr Steven Bowe
Scheme Discovery Projects
Role Investigator
Funding Start 2010
Funding Finish 2012
GNo G0190025
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Persistence of depressive symptoms and factors associated with depressive symptoms, across urban, rural and regional communities$52,500

Funding body: Australian Rotary Health

Funding body Australian Rotary Health
Project Team Professor Brian Kelly, Professor John Attia, Doctor Kerry Inder
Scheme Mental Health Research Grant
Role Investigator
Funding Start 2010
Funding Finish 2013
GNo G0900233
Type Of Funding Aust Competitive - Non Commonwealth
Category 1NS
UON Y

Evaluating the effectiveness of a strategy to increase the adoption of best evidence practice. A cluster randomised controlled trial in acute stroke care $50,000

Funding body: Victorian Department of Health

Funding body Victorian Department of Health
Project Team Laureate Professor Robert Sanson-Fisher, Conjoint Professor Chris Levi, Associate Professor Christine Paul, Conjoint Professor Cate d'Este, Professor Mark Parsons, Professor Christopher Bladin, Professor Richard Lindley, Professor John Attia
Scheme Project Grant
Role Investigator
Funding Start 2010
Funding Finish 2014
GNo G1100824
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Implementation of thrombolytic therapy in acute stroke. A cluster randomised trial$30,000

Funding body: BellBerry Limited

Funding body BellBerry Limited
Project Team Conjoint Professor Chris Levi, Professor John Attia, Associate Professor Christine Paul, Professor Mark Parsons, Professor Christopher Bladin, Professor Richard Lindley, Conjoint Professor Cate d'Este
Scheme Near Miss
Role Investigator
Funding Start 2010
Funding Finish 2014
GNo G0900221
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Zinc as a target for prevention of type-2 diabetes$15,000

Funding body: Hunter Children`s Research Foundation

Funding body Hunter Children`s Research Foundation
Project Team Professor John Attia, Doctor Milton Hasnat, Associate Professor Mark McEvoy, Doctor Amanda Patterson, Doctor Sham Acharya, Mr Steven Bowe
Scheme Research Grant
Role Lead
Funding Start 2010
Funding Finish 2010
GNo G1000450
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Genetic influences in colorectal cancer: a global consortium$9,998

Funding body: Hunter Children`s Research Foundation

Funding body Hunter Children`s Research Foundation
Project Team Professor Rodney Scott, Professor John Attia, Associate Professor Mark McEvoy
Scheme Research Grant
Role Investigator
Funding Start 2010
Funding Finish 2010
GNo G0900152
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

20095 grants / $1,419,923

Australian stroke genetics collaborative - Genome-wide association study in ischaemic stroke$1,108,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Chris Levi, Conjoint Associate Professor Jonathan Sturm, Professor John Attia, Professor Rodney Scott, Doctor Lisa Lincz, Dr Simon Koblar, Professor Pablo Moscato
Scheme Project Grant
Role Investigator
Funding Start 2009
Funding Finish 2011
GNo G0188856
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

LDX analyser (fingerprick unit) x4, piCo Smokerlyzer (Carboxymeter)x4, Universal cardboard disposable mouthpieces for piCo smokerlyzer x4 and Universal d pieces for piCo Smokerlyzer x4$20,775

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Amanda Baker, Doctor Frances Kay-Lambkin, Doctor Alyna Turner, Associate Professor Juanita Todd, Professor Robin Callister, Doctor Sally Hunt, Professor Brian Kelly, Professor John Attia, Associate Professor Jennifer Bowman, Doctor Paula Wye
Scheme Equipment Grant
Role Investigator
Funding Start 2009
Funding Finish 2009
GNo G0189849
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

Development and transfer of data linkage key and dataset for SHOAMP data and blood samples$13,387

Funding body: Department of Veterans` Affairs

Funding body Department of Veterans` Affairs
Project Team Conjoint Professor Cate d'Este, Professor John Attia
Scheme Research Grant
Role Investigator
Funding Start 2009
Funding Finish 2009
GNo G1000008
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

Vascular Ischaemia Study$10,400

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Conjoint Professor Chris Levi, Professor John Attia, Professor Rodney Scott, Doctor Michael Seldon, Doctor Lisa Lincz, Conjoint Associate Professor Jonathan Sturm
Scheme Research Grant
Role Investigator
Funding Start 2009
Funding Finish 2009
GNo G0900120
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

20082 grants / $861,224

Genes and environment in the risk of early age-related macular degeneration: a population-based case-control study$701,224

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor John Attia, Conjoint Professor Wayne Smith, Professor Pablo Moscato
Scheme Project Grant
Role Lead
Funding Start 2008
Funding Finish 2010
GNo G0189168
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

HMRI Senior Research Fellow$160,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor John Attia, Emeritus Professor Maree Gleeson, Professor Rodney Scott, Conjoint Professor Vaughan Carr, Conjoint Professor Stephen Ackland, Professor Michael Hazelton, Professor Trevor Day
Scheme Senior Fellowship
Role Lead
Funding Start 2008
Funding Finish 2009
GNo G0188558
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

20077 grants / $219,708

Systematic Review of the effects of Long Work Hours on Workplace Safety & Performance$69,000

Funding body: National Occupational Health & Safety Commission

Funding body National Occupational Health & Safety Commission
Project Team

Maya Guest

Scheme Tender
Role Investigator
Funding Start 2007
Funding Finish 2007
GNo
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON N

Prevention of heart disease by pneumococcal vaccination$50,000

Funding body: Pfizer Australia

Funding body Pfizer Australia
Project Team Professor Phil Hansbro, Dr Sukumaran Thambar, Professor John Attia, Associate Professor Mark McEvoy
Scheme Cardiovascular Lipid Research Grants
Role Investigator
Funding Start 2007
Funding Finish 2007
GNo G0186642
Type Of Funding Aust Competitive - Non Commonwealth
Category 1NS
UON Y

Cancer Cluster Study$48,030

Funding body: Newcastle Innovation

Funding body Newcastle Innovation
Project Team Doctor Maya Guest, Ms Sandra McBurnie, Professor John Attia, Conjoint Professor Cate d'Este
Scheme Administered Research
Role Investigator
Funding Start 2007
Funding Finish 2008
GNo G0188347
Type Of Funding Internal
Category INTE
UON Y

Healthy Airways and Obstructive Lung Disease (HAROLD)$20,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Conjoint Professor Wayne Smith, Associate Professor Lisa Wood, Professor John Attia, Associate Professor Regina Berretta, Professor Pablo Moscato
Scheme Project Grant
Role Investigator
Funding Start 2007
Funding Finish 2007
GNo G0187246
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Hewlett Packard 7890 series gas chromatograph with accessories$20,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Associate Professor Lisa Wood, Conjoint Professor Peter Wark, Conjoint Professor Peter Gibson, Associate Professor Jodie Simpson, Doctor Vanessa Murphy, Laureate Professor Paul Foster, Professor Phil Hansbro, Conjoint Associate Professor Vicki Clifton, Professor Clare Collins, Conjoint Professor Wayne Smith, Professor John Attia
Scheme Equipment Grant
Role Investigator
Funding Start 2007
Funding Finish 2007
GNo G0188191
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

The impact of Asymmetrical Dimethylarginine on Cognition in a population-based cohort$7,678

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Associate Professor Mark McEvoy, Conjoint Professor Wayne Smith, Conjoint Associate Professor Peter Schofield, Professor John Attia
Scheme Pilot Grant
Role Investigator
Funding Start 2007
Funding Finish 2007
GNo G0187872
Type Of Funding Internal
Category INTE
UON Y

Genetic polymorphisms in the native thrombolytic systems as risk factors for ischaemic stroke.$5,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Conjoint Professor Chris Levi, Professor John Attia, Professor Rodney Scott, Dr Amanda Thrift
Scheme Research Grant
Role Investigator
Funding Start 2007
Funding Finish 2007
GNo G0187320
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

20068 grants / $748,641

Prevention of heart disease by pneumococcal vaccination$55,000

Funding body: Pfizer Cardiovascular lipid research grants

Funding body Pfizer Cardiovascular lipid research grants
Project Team

Suku Thambar

Scheme Cardiovascular Lipid Research Grants
Role Investigator
Funding Start 2006
Funding Finish 2007
GNo
Type Of Funding Aust Competitive - Non Commonwealth
Category 1NS
UON N

The impact of Anticholinergic activity, apolipoprotein E and high-affinity choline transporter genotype on cognition in a population-based co-hort: a pilot study$15,500

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Associate Professor Mark McEvoy, Conjoint Associate Professor Peter Schofield, Conjoint Professor Wayne Smith, Doctor Janine Duke, Professor John Attia
Scheme Project Grant
Role Investigator
Funding Start 2006
Funding Finish 2006
GNo G0186170
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

The rEMISS Study. Exploring the Experience of Mood Disturbance in community dwelling Stroke Survivors: a longitudinal study$14,500

Funding body: John Hunter Hospital Charitable Trust

Funding body John Hunter Hospital Charitable Trust
Project Team

Chris Levi

Scheme Charitable Trusts and Foundations Project
Role Investigator
Funding Start 2006
Funding Finish 2007
GNo
Type Of Funding Aust Competitive - Non Commonwealth
Category 1NS
UON N

Is pneumococcal vaccination protective for cardiovascular disease? Elucidating the relationship between pneumococcal vaccination and protective anti-oxidised LDL antibodies$13,448

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor John Attia
Scheme Pilot Grant
Role Lead
Funding Start 2006
Funding Finish 2006
GNo G0186696
Type Of Funding Internal
Category INTE
UON Y

Elucidating the mechanics of transgenerational toxicity in the ageing male$10,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Doctor Shaun Roman, Professor John Attia, Dr Elizabeth Gillam
Scheme Near Miss Grant
Role Investigator
Funding Start 2006
Funding Finish 2006
GNo G0186080
Type Of Funding Internal
Category INTE
UON Y

10 year follow-up of patients attending a flexible eating insulin education program$10,000

Funding body: Novo Nordisk Foundation

Funding body Novo Nordisk Foundation
Project Team

Julia Lowe

Scheme Project Grant
Role Investigator
Funding Start 2006
Funding Finish 2007
GNo
Type Of Funding Aust Competitive - Non Commonwealth
Category 1NS
UON N

Identification of single nucleotide polymorphisms that are associated with an increased risk of colectoral cancer$9,050

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Rodney Scott, Professor Robyn Ward, Assoc. Prof Nicholas Hawkins, Professor John Attia, Conjoint Professor David Sibbritt, Professor Pablo Moscato
Scheme Near Miss Grant
Role Investigator
Funding Start 2006
Funding Finish 2006
GNo G0186073
Type Of Funding Internal
Category INTE
UON Y

20054 grants / $166,088

Genetic polymorphisms in the native thrombolytic and thrombotic systems as risk factors for ischaemic stroke$106,488

Funding body: National Heart Foundation of Australia

Funding body National Heart Foundation of Australia
Project Team Conjoint Professor Chris Levi, Professor John Attia, Professor Rodney Scott, Dr Amanda Thrift
Scheme Grant-In-Aid
Role Investigator
Funding Start 2005
Funding Finish 2006
GNo G0184034
Type Of Funding Aust Competitive - Non Commonwealth
Category 1NS
UON Y

Prevalence and risk factors for peripheral neuropathy in newly-diagnosed type 2 diabetes$30,000

Funding body: Diabetes Australia

Funding body Diabetes Australia
Project Team Conjoint Professor Wayne Smith, Professor John Attia, Conjoint Associate Professor Julia Lowe, Doctor Janine Duke
Scheme Research Grant
Role Investigator
Funding Start 2005
Funding Finish 2005
GNo G0185002
Type Of Funding Aust Competitive - Non Commonwealth
Category 1NS
UON Y

The effect of dietary folate, environmental toxins, and genetic polymorphisms in parents and children in determining the risk of childhood acute lymphoblastic leukaemia$20,000

Funding body: Royal Australasian College of Physicians

Funding body Royal Australasian College of Physicians
Project Team Professor John Attia, Doctor Anne Ronan
Scheme Arnott Fellowship in Cancer Research
Role Lead
Funding Start 2005
Funding Finish 2005
GNo G0185060
Type Of Funding Not Known
Category UNKN
UON Y

Kryos cryogenic vessel controller$9,600

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team

McEvoy

Scheme Infrastructure Grants
Role Investigator
Funding Start 2005
Funding Finish 2005
GNo
Type Of Funding Not Known
Category UNKN
UON N

20044 grants / $256,065

Nature, nuture and acute childhood lymphoblastic leukaemia$193,500

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Rodney Scott, Professor John Attia
Scheme Project Grant
Role Investigator
Funding Start 2004
Funding Finish 2006
GNo G0183209
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Ambient baroque music in dementia$30,000

Funding body: Bernard Judd Foundation

Funding body Bernard Judd Foundation
Project Team Professor Kichu Nair, Professor John Attia, Conjoint Professor John Marley
Scheme Research Grant
Role Investigator
Funding Start 2004
Funding Finish 2004
GNo G0184809
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Novel genetic and environmental risk factors in atherothrombosis: The role of variation in Cox-2, tpA and PAI-1 activity$28,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Conjoint Professor Chris Levi, Conjoint Professor David Henry, Dr Patricia McGettigan, Professor John Attia, Professor Mark Parsons, Dr Michael Seldon, Professor Rodney Scott
Scheme Research Grant
Role Investigator
Funding Start 2004
Funding Finish 2004
GNo G0183749
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Visit of Mrs Ammarin Thakkinstain 1 March 2004 to 30 May 2004$4,565

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor John Attia
Scheme Visitor Grant
Role Lead
Funding Start 2004
Funding Finish 2004
GNo G0183802
Type Of Funding Internal
Category INTE
UON Y

20031 grants / $195,000

Research Fellows in Epidemiology$195,000

Funding body: Vicent Fairfax Family Foundation

Funding body Vicent Fairfax Family Foundation
Project Team Professor Julie Byles, Professor John Attia, Conjoint Professor Wayne Smith
Scheme Research Grant
Role Investigator
Funding Start 2003
Funding Finish 2005
GNo G0182726
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

20024 grants / $1,173,786

Study of health outcomes in aircraft maintenance personnel (Phase II and III)$893,786

Funding body: Commonwealth department of veterans affairs

Funding body Commonwealth department of veterans affairs
Project Team

Catherine D'Este

Scheme Tender
Role Investigator
Funding Start 2002
Funding Finish 2004
GNo
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON N

Study of health outcomes in aircraft maintenance personnel (Phase I)$275,000

Funding body: Commonwealth department of veterans affairs

Funding body Commonwealth department of veterans affairs
Project Team

Catherine D'Este

Scheme Tender
Role Investigator
Funding Start 2002
Funding Finish 2003
GNo
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON N

American-Heart Association/Asia Pacific Scientific Forum, Hawaii, 23-26 April 2002$2,500

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor John Attia
Scheme Travel Grant
Role Lead
Funding Start 2002
Funding Finish 2002
GNo G0181696
Type Of Funding Internal
Category INTE
UON Y

World Congress of Epidemiology, Montreal, Canada 18-22 August, 2002$2,500

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor John Attia
Scheme Travel Grant
Role Lead
Funding Start 2002
Funding Finish 2002
GNo G0182156
Type Of Funding Internal
Category INTE
UON Y

20012 grants / $68,600

The Genetic Origins of Childhood Cancer.$40,000

Funding body: John Hunter Children`s Hospital Research Foundation

Funding body John Hunter Children`s Hospital Research Foundation
Project Team Professor Rodney Scott, Professor John Attia, Doctor Frank Alvaro
Scheme Research Grant (Defunct)
Role Investigator
Funding Start 2001
Funding Finish 2001
GNo G0181219
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Development of two courses in molecular and genetic epidemiology.$28,600

Funding body: Commonwealth Department of Health & Aged Care

Funding body Commonwealth Department of Health & Aged Care
Project Team Professor John Attia, Professor Julie Byles
Scheme Innovative Projects in Relation to PHERP
Role Lead
Funding Start 2001
Funding Finish 2001
GNo G0180974
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

20001 grants / $9,200

The effect of angiotensin-converting enzyme gene variants on survival post-myocardial infarction and on response to ACE inhibitors.$9,200

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor John Attia
Scheme Early Career Researcher Grant
Role Lead
Funding Start 2000
Funding Finish 2000
GNo G0179327
Type Of Funding Internal
Category INTE
UON Y

19981 grants / $96,480

Tea tree oil as a topical decolonisation solution for adult inpatients with Methicillin-resistant Staphylococcus Aureas$96,480

Funding body: Rural Industries Research & Development Corporation

Funding body Rural Industries Research & Development Corporation
Project Team Professor John Attia, Meredith Caelli, Assoc. Prof T Riley
Scheme Research and Development Project
Role Lead
Funding Start 1998
Funding Finish 2000
GNo G0177627
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y
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Research Supervision

Number of supervisions

Completed20
Current9

Total current UON EFTSL

Masters0.1
PhD1.18

Current Supervision

Commenced Level of Study Research Title / Program / Supervisor Type
2016 Masters Heart Failure Outcomes in Hunter New England Area
M Philosophy (Medicine), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2015 PhD Can Individualized Blood Pressure (BP) Targets Reduce the Incidence of New-Onset Acute Kidney Injury Among Critically Ill Patients With Shock?
PhD (Medicine), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2014 PhD Defining the Immune System and Preventable Mortality in Geriatric Hip Fractures
PhD (Surgical Science), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2014 PhD Does Weighing During Pregnancy Prevent Excessive Gestational Weight Gain? A Mixed-Method Study
PhD (CommunityMed & ClinEpid), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2014 PhD Smoke-Free Recovery: Smoking Cessation for Hospitalised Patients
PhD (Behavioural Science), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2013 PhD Impact of Dietary Protein on Postprandial Blood Glucose Levels in Type 1 Diabetes Mellitus
PhD (Medicine), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2012 PhD Genetic and Non-Genetic Studies of Type 2 Diabetes in Three Susceptible Asian Populations: Malay, Chinese and Indian
PhD (Medical Genetics), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2012 PhD Potential Cardio-Protective Effect of Pneumococcal Vaccine
PhD (Clinical Pharm), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2012 PhD The Role of Autoantibodies in the Development of Depression
PhD (CommunityMed & ClinEpid), Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor

Past Supervision

Year Level of Study Research Title / Program / Supervisor Type
2016 PhD Diet and Depression in Community-Dwelling Adults
PhD (CommunityMed & ClinEpid), Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2015 PhD Health Determinants in Australian Communities: A Multilevel Investigation of the Influence of Personal and Contextual Characteristics
PhD (Psychiatry), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2015 PhD The Role of Zinc in Chronic Disease
PhD (CommunityMed & ClinEpid), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2015 PhD Environmental Determinants of Lupus Flares
PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2014 PhD Exploring the Long-Term Experience of Psychological Morbidity in Community-Dwelling Stroke Survivors
PhD (Medicine), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2014 PhD The Inflammation Hypothesis of Depression: Cross Sectional Associations, Temporal Relationships and the Confounds of Comorbidity
PhD (Psychiatry), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2014 PhD The Optimal Timing of Surgical Fracture Stabilization in Trauma Patients
PhD (Medicine), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2014 Masters The Relationship Between Early Alzheimer's Disease, Apolipoprotein E Genotyping & Hippocampal MRI Volumes
M Philosophy (ComMed&ClinEpid), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2013 PhD Suicide in Urban and Rural Australia: Determinants, Moderators and Treatment Options for Suicidal Thoughts and Behaviours
PhD (Psychiatry), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2012 Masters Systematic Review and Network Meta-Analysis of Intravenous Ibuprofen Vs. Intravenous Indomethacin Vs. Placebo in the Management of Clinically and/or Echocardiographically Important Patent Ductus Arteriosus in Preterm Infants at Greater than 24 Hours of Life
M Philosophy (ComMed&ClinEpid), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2012 PhD Factor V Leiden and Adverse Pregnancy Outcome
PhD (CommunityMed & ClinEpid), Faculty of Health and Medicine, The University of Newcastle
Sole Supervisor
2012 PhD The Food and Nutrient Intake and Physical Activity of Australian Aboriginal and Torres Strait Islander and Non-Indigenous Rural Children
PhD (Behavioural Science), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2012 PhD The Study of Health Outcomes in Aircraft Maintenance Personnel: Sensory System Effects
PhD (CommunityMed & ClinEpid), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2010 PhD The Clinical Efficacy of Tea Tree Oil as an Alternative Topical Decolonisation Agent for Adult Inpatients with Meticillin-Resistant Staphylococcus Aureus
PhD (CommunityMed & ClinEpid), Faculty of Health and Medicine, The University of Newcastle
Sole Supervisor
2010 PhD Genetic Polymorphisms of Platelet Glycoprotein and Cyclooxygenase-2 Genes and Their Influence on Risk of Ischaemic Stroke, 90 Day Post-Stroke Outcome, and Gene-Environment Interactions
PhD (Medicine), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2007 PhD Clinical Epidemiology of B Natriuretic Peptides as Tests for Heart Failure in Australian General Practice
PhD (CommunityMed & ClinEpid), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2006 PhD Cardiovascular Risk Factors in Asians and Caucasians
PhD (CommunityMed & ClinEpid), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2004 PhD Meta-analysis of Molecular Association Studies
PhD (CommunityMed & ClinEpid), Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2004 PhD Molecular Epidemiological Study of Childhood Cancer
PhD (CommunityMed & ClinEpid), Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2003 PhD Diet, Lifestyle, and Risk Factors for Forearm Fracture in Postmenopausal Women
PhD (CommunityMed & ClinEpid), Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
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Research Projects

Humira and Endothelial Function in Rheumatoid Arthritis 2 (HEART RA - 2) 2015 -

Hunter HEART-RA will answer many questions regarding cardiovascular disease in ACPA-positive RA. However, it will not evaluate ACPA-negative RA patient group and cannot answer the question of when, at which stage in the development of RA, cardiovascular risk becomes elevated and which inflammatory and non-inflammatory processes may be responsible. Hunter HEAT-RA-2 has been designed to investigate these questions in greater detail. 

Hunter HEART-RA-2 is an extension of Hunter HEART-RA consisting of 2 parts.

Part 1: Randomised Controlled Trial evaluating the Effect of the TNF-Inhibitor drug Humira (adalimumab) upon cardiovascular risk as measured by a platform of cardiovascular assessments. This second study will include ACPA-negative RA patients and more comprehensive assessments of cardiovascular function and inflammatory burden.

Part 2: Cross-Sectional Study evaluating cardiovascular risk in First Degree Relatives of patients with Rheumatoid Arthritis, Healthy Unrelated Controls and people with immunological markers of rheumatoid arthritis without clinical disease.  

In both parts of this study there will be a platform of assessments of articular inflammation, cardiovascular function and laboratory assessments. In addition to the routine assessments of inflammatory burden (clinical joint counts, ESR and CRP) musculoskeletal ultrasound will be used to detect subclinical joint inflammation.  The platform of cardiovascular assessments include endothelial function (EndoPAT), central arterial pressure indices, aortic stiffness (carotid-femoral pulse wave velocity) and carotid ultrasound (carotid intimal medial thickness and carotid plaque measurement). Participants will have a range of genetic and immunological tests and a sub-group will participate in studies of NETosis. 

Grants

Humira and Endothelial Function in Rheumatoid Arthritis - 2 (HEART-RA-2)

Funding body: Abbvie Pharmaceuticals

Funding body Abbvie Pharmaceuticals
Description

Interim analysis in Hunter HEART-RA-1 confirmed that endothelial function correlates inversely with inflammatory burden in patients with anti-CCP positive rheumatoid arthritis (RA). However, it appears that other disease-specific but non-inflammatory mechanisms may contribute to cardiovascular disease in RA. This might include genetic factors, abnormalities of lipid transport and newly described immune mechanisms such as NETosis. HEART-RA-1 also only evaluated patients with anti-CCP positive RA. 

HEART-RA-2 will consist of 2 parts:

Part 1, a randomised controlled trial will evaluate the effect of Humira upon endothelial function in anti-CCP antibody positive and anti-CCP antibody negative patients with RA. 

Part 2 will evaluate non-inflammatory mechanisms of cardiovascular disease by taking inflammation out of the equation. This will be done by studying people with Pre-RA i.e. who have evidence of RA on blood test of on ultrasound but no clinical evidence of RA.

Scheme Abbvie Investigator-Initiated Grant

Collaborators

Name Organisation
Professor John Richard Attia University of Newcastle
Professor Phil Michael Hansbro University of Newcastle

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News

Equity and quality of healthcare

PhD Scholarship - Equity and Quality of healthcare in an Australian context

May 26, 2016

A PhD or Research Masters opportunity is available focusing on equity and quality of healthcare in an Australian context under the supervision of Laureate Professor Rob Sanson-Fisher and Professor John Attia

PhD Opportunity - Biomarker for early Alzheimer's disease

PhD Opportunity - Biomarker for early Alzheimer's disease

February 3, 2015

A PhD opportunity exists for someone with biological and analytic skills who would be interested in taking advantage of collected data from an NHMRC funded study focussed on a novel potential biomarker for early Alzheimer's disease under the supervision of Conjoint Associate Professor Peter Schofield and Professor John Attia.

sleep

sleep linked to diabetes

December 12, 2013

Getting less than six hours sleep each night (compared to seven hours) may increase type 2 diabetes risk by 30 per cent but has less impact on heart disease than previously thought, researchers from the University of Newcastle have found.

HMRI

New study shows genetic role in education

May 31, 2013

A multinational consortium of medical researchers and social scientists has found a link between educational attainment and tiny variations in a person's genetic sequence.

Professor John Attia

Position

Academic Director
CReDITSS Unit
School of Medicine and Public Health
Faculty of Health and Medicine

Contact Details

Email john.attia@newcastle.edu.au
Phone (02) 4042 0500
Fax (02) 40420039

Office

Room 3014
Building Hunter Medical Research Institute Building
Location Kookaburra Circuit, John Hunter Hospital Campus New Lambton NSW 2305

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