Staff Profile
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Career Summary
Qualifications
- PhD, University of Newcastle
Research
Research keywords
- Breast Cancer
- Cancer
- Chemotherapy
- Drug Development
- Dynamin
- Glioblastoma
- PP2A
Research expertise
Dr Sakoff is an experienced cell biologist and Chief Hospital Scientist in the Department of Medical Oncology at the Calvary Mater Newcastle Hospital. Dr Sakoff is the leader of the Experimental Therapeutics Group. She has made significant contributions to cancer research particularly in the development of small molecules for the treatment of cancer. Areas of expertise includes cell culture, drug screening, cell biology, proteomics, cell cycle analysis, drug combination studies, clinical toxicity.
Languages
- English
Fields of Research
| Code | Description | Percentage |
|---|---|---|
| 111200 | Oncology And Carcinogenesis | 100 |
Awards
Research Award.
| 2000 | Young medical researcher of the year Hunter Medical Insitute (Australia) Young medical researcher of the year |
|---|
Teaching
Teaching keywords
- Cancer
Teaching expertise
Selected lectures in drug development.
Edit
- Indicates that the researcher may be seeking students for this project.The Hunter Cancer Biobank (HCB): Maximising community value through validation, annotation and distribution throughout NSW$292,300
The role of clathrin in the spindle assembly checkpoint and as an anticancer target$245,100
High-Resolution Isoelectric Phosphoprotein Signalling System for Signalling Research, Biomarker Validation and Drug Development – Equipment Grant$143,394
Identification of a novel target for the treatment of hormone positive breast cancer$30,000
Mitotane pharmacodynamics in Adrenocortical Cancer in children and adults
$20,000
The role of clathrin in the spindle assembly checkpoint and as an anticancer target$15,000
Ultrasonic Homogenizer System and -80 ºC Freezers for chemical and biological sample storage$10,000
Development of pthaladyn-based dynamin I-selective inhibitors for treatment of epilepsy$544,831
Chemical Biology$444,961
Computational prediction and functional clarification of novel drug combination
strategies for the treatment of brain tumours$50,000
Eppendorf mastercycler pro with thermomixer comfort and 5430R centrifuge$15,000
New small molecules for the treatment of neuroblastoma$35,000
FACSAria - Fluorescence activated cell sorter$300,000
HMRI Contribution toward FACSAria - Fluorescence activated cell sorter$52,000
Overcoming radiation resistance in malignant melanoma$11,000
High Pressure and Fluorous Approaches to fostriecin libraries: New Therapeutic Opportunities.$50,000
New targets for chemotherapy: anti-cancer drugs that target protein phosphatases$10,000
Synergistic interaction between thymidylate synthase and protein phosphatase inhibition in colon cancer cells$10,450
Predicting bone marrow regeneration in cancer patients through the use of telomere quantitative (Q)-FISH$10,000
Pulse Education Prize for 2001$3,000
A counter-intuitive anticancer treatment.$20,000
Influence of Haematopoetic stem cell telorase activity on bone marrow recovery following myoablative therapy.$20,000
Young Medical Researcher of the Year.$5,000
Selective Inhibitors of Protein Phosphatases as Anti-cancer agents$25,000
Grants and Funding
Summary
| Number of grants | 24 |
|---|---|
| Total funding | $2,362,036 |
For project grants received where the lead institution is other than the University of Newcastle, details are shown in italics.
Click on a grant title below to expand the full details for that specific grant.
2012 (7 grants)
The Hunter Cancer Biobank (HCB): Maximising community value through validation, annotation and distribution throughout NSW$292,300
Funding Body: Cancer Institute NSW
| Project Team | ||
|---|---|---|
| Professor John Forbes, Conjoint Professor Stephen Ackland, Professor Rodney Scott, Conjoint Associate Professor Barbara Young, Professor Hubert Hondermarck, Conjoint Professor Leonie Ashman, Professor Xu Dong Zhang, Doctor Kelly Kiejda, Doctor Nikki Verrills, Doctor Jennette Sakoff, Ms Janine Lombard, Doctor Jude Weidenhofer, Doctor Pradeep Tanwar | ||
| Scheme | Role | |
| Infrastructure Grants | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $292,300 | 2012 | 2014 |
| GNo:G1200798 | ||
The role of clathrin in the spindle assembly checkpoint and as an anticancer target$245,100
Funding Body: NHMRC (National Health & Medical Research Council)
| Project Team | ||
|---|---|---|
| Ms Megan Chircop, Professor Adam McCluskey, Professor Phillip Robinson, Doctor Jennette Sakoff | ||
| Scheme | Role | |
| Project Grant | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $245,100 | 2012 | 2014 |
| GNo:G1101106 | ||
High-Resolution Isoelectric Phosphoprotein Signalling System for Signalling Research, Biomarker Validation and Drug Development – Equipment Grant$143,394
Funding Body: Hunter Medical Research Institute
| Project Team | ||
|---|---|---|
| Doctor Rick Thorne, Professor Xu Dong Zhang, Professor Hubert Hondermarck, Conjoint Professor Stephen Ackland, Doctor Lisa Lincz, Doctor Jennette Sakoff, Conjoint Professor Leonie Ashman | ||
| Scheme | Role | |
| Project Grant | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $143,394 | 2012 | 2012 |
| GNo:G1200555 | ||
Identification of a novel target for the treatment of hormone positive breast cancer$30,000
Funding Body: Hunter Medical Research Institute
| Project Team | ||
|---|---|---|
| Doctor Jennette Sakoff, Dr Carole Gilbert, Professor Adam McCluskey | ||
| Scheme | Role | |
| Breast Cancer Project Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $30,000 | 2012 | 2012 |
| GNo:G1200716 | ||
Mitotane pharmacodynamics in Adrenocortical Cancer in children and adults
$20,000
Funding Body: Hunter Medical Research Institute
| Project Team | ||
|---|---|---|
| Conjoint Professor Stephen Ackland, Doctor Jennette Sakoff, Ms Madhu Garg | ||
| Scheme | Role | |
| Project Grant | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $20,000 | 2012 | 2013 |
| GNo:G1200319 | ||
The role of clathrin in the spindle assembly checkpoint and as an anticancer target$15,000
Funding Body: Trade and Investment NSW
| Project Team | ||
|---|---|---|
| Professor Adam McCluskey, Doctor Jennette Sakoff | ||
| Scheme | Role | |
| TechVouchers Program | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $15,000 | 2012 | 2012 |
| GNo:G1200796 | ||
Ultrasonic Homogenizer System and -80 ºC Freezers for chemical and biological sample storage$10,000
Funding Body: NHMRC (National Health & Medical Research Council)
| Project Team | ||
|---|---|---|
| Professor Adam McCluskey, Professor Eileen McLaughlin, Professor Peter Lewis, Ms Belinda Nixon, Doctor Shaun Roman, Doctor Jennette Sakoff, Doctor Ian Grainge | ||
| Scheme | Role | |
| Equipment Grant | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $10,000 | 2012 | 2012 |
| GNo:G1100986 | ||
2011 (4 grants)
Development of pthaladyn-based dynamin I-selective inhibitors for treatment of epilepsy$544,831
Funding Body: NHMRC (National Health & Medical Research Council)
| Project Team | ||
|---|---|---|
| Professor Adam McCluskey, Professor Phillip Robinson, Professor Terence O'Brien, Ms Megan Chircop, Doctor Jennette Sakoff | ||
| Scheme | Role | |
| Development Grants | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $544,831 | 2011 | 2013 |
| GNo:G1000740 | ||
Chemical Biology$444,961
Funding Body: University of Newcastle
| Project Team | ||
|---|---|---|
| Professor Adam McCluskey, Doctor Warwick Belcher, Doctor Ian Grainge, Professor Christopher Grof, Professor Peter Lewis, Professor Eileen McLaughlin, Doctor Shaun Roman, Conjoint Professor Ray Rose, Doctor Jennette Sakoff, Doctor Nikki Verrills | ||
| Scheme | Role | |
| Priority Research Centre | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $444,961 | 2011 | 2015 |
| GNo:G1100052 | ||
Computational prediction and functional clarification of novel drug combination
strategies for the treatment of brain tumours$50,000
Funding Body: Maitland Cancer Appeal Committee
| Project Team | ||
|---|---|---|
| Professor Pablo Moscato, Mr Dan Johnstone, Associate Professor Regina Berretta, Doctor Luke Mathieson, Professor Manuel Graeber, Doctor Jennette Sakoff | ||
| Scheme | Role | |
| Research Project | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $50,000 | 2011 | 2011 |
| GNo:G1100275 | ||
Eppendorf mastercycler pro with thermomixer comfort and 5430R centrifuge$15,000
Funding Body: NHMRC (National Health & Medical Research Council)
| Project Team | ||
|---|---|---|
| Professor Eileen McLaughlin, Professor Peter Lewis, Professor Adam McCluskey, Conjoint Professor Keith Jones, Associate Professor Brett Nixon, Doctor Shaun Roman, Doctor Jennette Sakoff, Doctor Ian Grainge, Doctor Janet Holt, Doctor Xiao Yang | ||
| Scheme | Role | |
| Equipment Grant | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $15,000 | 2011 | 2011 |
| GNo:G1100028 | ||
2010 (1 grants)
New small molecules for the treatment of neuroblastoma$35,000
Funding Body: Hunter Medical Research Institute
| Project Team | ||
|---|---|---|
| Dr Carole Gilbert, Doctor Jennette Sakoff, Ms Megan Chircop | ||
| Scheme | Role | |
| Paediatric Oncology Project Grant | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $35,000 | 2010 | 2010 |
| GNo:G0900192 | ||
2007 (2 grants)
FACSAria - Fluorescence activated cell sorter$300,000
Funding Body: Cancer Institute NSW
| Project Team | ||
|---|---|---|
| Doctor Nikki Verrills, Conjoint Professor Leonie Ashman, Laureate Professor John Aitken, Professor Eileen McLaughlin, Professor Alistair Sim, Doctor Rick Thorne, Doctor Jennette Sakoff | ||
| Scheme | Role | |
| Infrastructure Grants | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $300,000 | 2007 | 2007 |
| GNo:G0187666 | ||
HMRI Contribution toward FACSAria - Fluorescence activated cell sorter$52,000
Funding Body: Hunter Medical Research Institute
| Project Team | ||
|---|---|---|
| Doctor Nikki Verrills, Conjoint Professor Leonie Ashman, Laureate Professor John Aitken, Professor Eileen McLaughlin, Professor Alistair Sim, Doctor Rick Thorne, Doctor Jennette Sakoff | ||
| Scheme | Role | |
| Equipment Grant | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $52,000 | 2007 | 2007 |
| GNo:G0188207 | ||
2006 (1 grants)
Overcoming radiation resistance in malignant melanoma$11,000
Funding Body: Hunter Medical Research Institute
| Project Team | ||
|---|---|---|
| Doctor Lisa Lincz, Doctor Jennette Sakoff | ||
| Scheme | Role | |
| Project Grant | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $11,000 | 2006 | 2007 |
| GNo:G0186528 | ||
2003 (1 grants)
High Pressure and Fluorous Approaches to fostriecin libraries: New Therapeutic Opportunities.$50,000
Funding Body: ARC (Australian Research Council)
| Project Team | ||
|---|---|---|
| Professor Adam McCluskey, Assoc. Prof David Young, Doctor Jennette Sakoff | ||
| Scheme | Role | |
| Discovery Projects | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $50,000 | 2003 | 2003 |
| GNo:G0182117 | ||
2002 (1 grants)
New targets for chemotherapy: anti-cancer drugs that target protein phosphatases$10,000
Funding Body: University of Newcastle
| Project Team | ||
|---|---|---|
| Professor Adam McCluskey, Conjoint Professor Stephen Ackland, Doctor Jennette Sakoff | ||
| Scheme | Role | |
| Project Grant | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $10,000 | 2002 | 2002 |
| GNo:G0181459 | ||
2001 (3 grants)
Synergistic interaction between thymidylate synthase and protein phosphatase inhibition in colon cancer cells$10,450
Funding Body: University of Newcastle
| Project Team | ||
|---|---|---|
| Doctor Jennette Sakoff | ||
| Scheme | Role | |
| Early Career Researcher Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $10,450 | 2001 | 2001 |
| GNo:G0181233 | ||
Predicting bone marrow regeneration in cancer patients through the use of telomere quantitative (Q)-FISH$10,000
Funding Body: Hunter Medical Research Institute
| Project Team | ||
|---|---|---|
| Doctor Lisa Lincz, Doctor Jennette Sakoff | ||
| Scheme | Role | |
| Lions Club of Stroud | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $10,000 | 2001 | 2001 |
| GNo:G0181502 | ||
Pulse Education Prize for 2001$3,000
Funding Body: Hunter Medical Research Institute
| Project Team | ||
|---|---|---|
| Doctor Jennette Sakoff | ||
| Scheme | Role | |
| Research Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $3,000 | 2001 | 2001 |
| GNo:G0181503 | ||
2000 (3 grants)
A counter-intuitive anticancer treatment.$20,000
Funding Body: Hunter Medical Research Institute
| Project Team | ||
|---|---|---|
| Doctor Jennette Sakoff | ||
| Scheme | Role | |
| Research Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $20,000 | 2000 | 2000 |
| GNo:G0180205 | ||
Influence of Haematopoetic stem cell telorase activity on bone marrow recovery following myoablative therapy.$20,000
Funding Body: Hunter Medical Research Institute
| Project Team | ||
|---|---|---|
| Doctor Lisa Lincz, Ms Kerry Fagan, Doctor Jennette Sakoff | ||
| Scheme | Role | |
| Research Grant | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $20,000 | 2000 | 2000 |
| GNo:G0180171 | ||
Young Medical Researcher of the Year.$5,000
Funding Body: Hunter Medical Research Institute
| Project Team | ||
|---|---|---|
| Doctor Jennette Sakoff | ||
| Scheme | Role | |
| Research Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $5,000 | 2000 | 2000 |
| GNo:G0180182 | ||
1999 (1 grants)
Selective Inhibitors of Protein Phosphatases as Anti-cancer agents$25,000
Funding Body: Hunter Medical Research Institute
| Project Team | ||
|---|---|---|
| Doctor Jennette Sakoff, Professor Adam McCluskey, Conjoint Professor Stephen Ackland | ||
| Scheme | Role | |
| Research Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $25,000 | 1999 | 1999 |
| GNo:G0178390 | ||
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Research Supervision
| Number of current supervisions | 1 |
|---|---|
| Total current UoN PhD EFTSL | 0.3 |
For supervisions undertaken at an institution other that the University of Newcastle, details are shown in italics, and the institution name is listed below the program name.
Current Supervision
| Commenced | Proposed Completion | Program | Supervisor Type | Research Title |
|---|---|---|---|---|
| 2013 | 2016 | PhD (Biological Sciences) | Co-Supervisor | An Investigation on the Consensus Between Different Transriptomic and Proteomic Analysis Results in Breast Cancer |
Edit
Dr Jennette Sakoff
| Work Phone | (02) 4921 1149 |
|---|---|
| Fax | (02) 4968 0384 |
| Jennette.Sakoff@newcastle.edu.au | |
| Position | Conjoint Lecturer Experimental Therapeutics Group School of Environmental and Life Sciences Faculty of Science and Information Technology |
| Focus Area | Chemistry |
| Office | Department of Medical Oncology, Calvary Mater Newcastle Hospital |
| URL: | www.newcastle.edu.au/profile/jennette-sakoff |
