Dr Jay Horvat

Dr Jay Horvat

Senior Lecturer

School of Biomedical Sciences and Pharmacy (Immunology and Microbiology)

Experimental models of disease

Dr Jay Horvat's preclinical research is cementing a scientific, nuanced understanding of our bodies' harmful and helpful immunological processes

Jay Horvat 

Dr Jay Horvat does his homework. He's using novel experimental models to fact check and fault-find, taking clinical observations and recapitulating them in smaller simulations to dissect and study the intricate architecture of multiple illnesses. Informing the development of innovative and preventative therapeutic treatments, this committed researcher stresses it's the endgame that's important. 

"The whole point is to discover molecular mechanisms in experimental models of disease that might similarly be occurring in human patients," he explains.

"This allows us to find new therapeutic targets for the development of treatment strategies that will hopefully translate into improved clinical outcomes for patients with a variety of diseases."

Spanning the microbiological, immunological and pharmacological fields, Jay's work has a particular emphasis on illustrating the roles played by bacteria and viruses in the pathogenesis of acute inflammatory conditions. Mindful of the profound economics of chronic diseases, particularly those with ill-defined triggers, variable clinical courses and not-yet-understood symptoms, this energetic investigator's research is also serving to help construct a "big picture."

"Infection-induced illnesses still cause immense mortality and place an enormous burden on healthcare systems," Jay notes.

"This leads to unsustainable personal and societal costs."

Joining the dots

Jay started his research career with a PhD at the University of Newcastle in 2004. Under the leadership of Professor Phil Hansbro, the four-year probe sought to solidify links between respiratory chlamydia and severe asthma.

"The latter is a major unmet clinical need," he affirms.

"Patients tend to be insensitive to anti-inflammatory steroid therapies so they're usually on higher doses of medications, which could have long-term negative effects."

"Patients are in and out of hospital more often and experience more frequent and extreme exacerbations too."

"They have a lower quality of life."

Appreciating the significance of these health and social impacts, Jay looked to identify how and why severe asthma develops both early on and later in life. He also aimed to confirm hypotheses that major infections drive the disease's most acute forms.

"We found that having a Chlamydia lung infection as either a neonatal or an infant leads to severe changes in lung function as well as more severe asthma," Jay reveals.

"The neonatal infection, in particular, leads to a form of disease that resembles emphysema."

Additionally providing evidence for the existence of a phenotype switch in adults who are infected while they have asthma, Jay's doctoral research highlighted a new association between a different series of immune responses and severe, steroid-insensitive asthma.

"Eosinophils have been classically aligned with asthma," he says.

"They come into the lung during an allergic flare-up and release a variety of inflammatory mediators that can cause you to have an asthma attack."

"If you get certain infections, however, you may get neutrophils coming into the lung instead."

"The processes that drive this type of inflammation are not as easily treated."

"So the infection is causing a shift from a type of immune response that is able to be suppressed by steroids to one that is not."

Better breathing

Jay has continued collaborating with Phil Hansbro post-PhD, actively participating in a number of other asthma projects at the Hunter Medical Research Institute. An extension of his earlier work, these studies explore several bacterial and viral infections and their ties to the disease's more severe forms. 

"We've shown that both Chlamydia and Haemophilus influenzae infections drive a neutrophilic subtype of asthma and that influenza and respiratory syncytial virus do not," the senior lecturer states.

"All four, however, similarly drive inflammation and lung function changes that cannot be treated with steroids."

"So we've got four infections doing slightly different things but having this universal effect of driving steroid-resistant inflammation and airway side responsiveness."

Simultaneously identifying a handful of cytokines associated with severe asthma, Jay's examination operates – and succeeds – on the proviso that if you can target a critical factor, you can meaningfully treat disease.

"Cells produce cytokines, which are basically signaling molecules that link cells up and allow them to talk to each other," he clarifies.

"They come out of the lung during an inflammatory response and tell the systemic immune response to mobilise and bring certain cells into the lung as well."

"Interleukin-1 beta is one we've found to be involved in this process."

"It's also one that's able to be depleted with antibodies, which actually suppresses the neutrophilic phenotype where steroids can't."

Looking to expand upon this knowledge, Jay's laboratory work focuses on molecular elements upstream of the newly discovered cytokine.

"A series of molecules, collectively called the 'inflammasome,' need to be activated in order for interleukin 1 beta to be secreted by cells," he says.

"If we intervene, we can stop its production and develop novel therapies for severe asthma."

"The same can be said about a novel micro-RNA we recently found."

In another offshoot of his doctoral research, Jay is surveying the effects of oxidative stress on the progression of infection-induced disease. Pointing to vitamin E as a viable, inexpensive therapeutic option, the ambitious academic is perhaps as cutting-edge as he is creative.

"If we can use this compound to treat severe asthma in early life, we can suppress all of the problems it causes later in life," he comments.

"It's quite exciting because vitamin E is something you can get from the local chemist or grocery store – it's already approved for general consumption."

Branching out and stepping up

A master at multitasking, Jay is currently working on some of his own independent research programs.

"Our most advanced one looks at how certain inflammatory stresses might affect Alzheimer's," he discloses.

"We're also examining the effect smoking has on neurodegenerative processes."

Jay and his team are hoping to uncover clues as to how and why the disease advances using their experimental models. They're similarly hoping to develop therapies that will stop or reverse it's progression. 

"Chlamydia bacteria has been found in plaques of the brains of patients with Alzheimer's," he shares of the initial findings.

"We have extended these findings to show that infections enter the brain during our models of respiratory infection."

"So the infection can get into the brain – and if it can do this, it could be doing all sorts of things to affect the progression of Alzheimer's."

"We have also shown that cigarette smoking accelerates the number and size of the plaques in the brain."

Extending his research interests even further afield, the Hunter Medical Research Institute innovator is also collaborating with Dr Simon Keely on a novel food allergy project. Marrying Simon's experience in inflammatory bowel disease and Jay's experience with allergy; the study aims to explore and determine the effects of antibiotics on the microbiome and how this may affect immune processes in the gut that predispose to allergic sensitisation to normally harmless food protein.

"Antibiotic use has been linked with increased risk of developing food allergy," Jay explains.

"Importantly, antimicrobials wipe out bacteria throughout the body, especially the gut, and we think this influences immune responses and might predispose to allergic sensitization."

"We show, for example, that taking a five day course of common prescribed antibiotics results in some pretty interesting changes to the immune system in the gut." 

"Our hypothesis is that food allergies are dramatically increasing in the developed world because we have a tendency to overtreat bacterial infections, which in turn has an effect on a healthy balanced immune system."

Infection protection

Jay is also collaborating with Professor Liz Milward on a research assignment that looks at the tricky interplay between iron, immune responses and infection in the context of lung disease.

"We want to understand how these three elements come together in the context of the lungs," he explains.

"Literature already tells us that both high and low iron can affect immune responses."

"It also tells us iron is important for bacterial replication."

Jay and Liz are linking a small number of hereditary disorders to this work, looking to identify ways of modifying immune responses through iron and, in doing so, improve treatment options for those suffering from a range of bacterial infections.

"Cystic fibrosis patients have increased levels of iron in their airways and this might be an important reason as to why they're more likely to get chronic colonisation with certain bacteria in the lungs," he acknowledges. 

At the same time, Jay is also working with a University of Newcastle PhD student on an adaptation of his earlier respiratory Chlamydia research. This time exploring the role of immune responses in stopping the progression of femalereproductive tract Chlamydia infections, Jay is seeking to develop a comprehensive understanding of the pathogenesis of sexually transmissible infection (STI).

"The immune system in the female reproductive tract is different to other organs as it needs to be able to tolerate the implantation of an embryo that is genetically different from the mother," he comments.

"Consequently, much of what we know about immunity from research of other tissues does not completely apply to the female reproductive tract."

"While Chlamydia is able to be treated with antibiotics, a lot of infections are asymptomatic so you don't go to the doctor to get treated."

Jay explains that if Chlamydia is untreated, it is able to advance into the uterus and fallopian tubes and eventually become chronic. The immune responses elicited in order to protect against this chronic upper reproductive tract infection, can cause damage to the delicate tissues in the female reproductive tract, and this can result in serious problems including infertility, pelvic inflammatory disease and ectopic pregnancy.

"We are trying to identify the protective immune factors, and those that cause damage, so that we can develop improved therapeutic strategies for preventing and treating disease," he shares.

"In collaboration with researchers at Monash University we have identified a novel type 1 interferon that protects against infection in the female reproductive tract."

"We are currently working with this factor to try to come up with innovative therapies for Chlamydia."

"These might be applicable to other STIs, like human papillomavirus, herpes and HIV."

More about Jay's Career

Related links

Jay Horvat

Experimental models of disease

Dr Jay Horvat’s preclinical research is cementing a scientific, nuanced understanding of our bodies’ harmful and helpful immunological processes

Read more

Career Summary

Biography

Research programs focus on;

Investigating the mechanisms of infection and high fat diet/obesity-induced, severe asthma

 Investigating the role of the newly discovered interferon (IFN)-epsilon in Chlamydia-induced reproductive tract disease

 Investigating the roles of infection and smoking in neurological diseases

Investigating the interplay between of iron, infection and immunity in the context of respiratory tract infections and lung disease

These research programs aim to inform novel targets for the development of improved therapeutic strategies for severe, steroid-resistant asthma, infection-associated respiratory and reproductive tract diseases and neurodegenerative diseases such as Alzheimer’s and multiple sclerosis.

Contribution to Research to Date; Infection & severe asthma: I have published a number of important studies that have significantly advanced the understanding of the immunological and pathophysiological interactions between lung infections and asthma. I showed for the first time that early-life, but not adult, infection enhances the severity of asthma in later life. I also showed that infection during asthma in adults results in the development of a phenotype resembling severe, steroid-resistant, neutrophilic asthma. I have since extended my research to investigate the mechanisms that underpin infection- and high fat diet/obesity-induced severe asthma in order to inform novel therapeutic strategies for disease.

Infection & reproductive tract disease: I have recently begun utilising my extensive experience in research of the immunobiology of Chlamydia infection to play a role in developing a successful research program that aims to understand the mechanisms of pathogenesis of Chlamydia reproductive tract and brain disease. We recently published a groundbreaking article in Science that demonstrated the role of IFN-epsilon in protecting against Chlamydia reproductive tract infection. I have also published a first author study that was the first to show that IL-13 promotes susceptibility to Chlamydia reproductive tract infections. 

Continuing Research; My aim is to continue investigations of the association between infections and obesity and severe, steroid-resistant asthma and of infection-induced, reproductive tract disease. I have been awarded an NHMRC Project Grant (2013-16) to elucidate the mechanisms of and discover new treatments for steroid-resistant asthma. I am also a Chief Investigator on a NHMRC Project Grant application for funding 2014-16 that will elucidate the mechanisms IFN-epsilon mediated protection against Chlamydia-infection in the reproductive tract.

Establishing Novel Research Programs; I have begun investigating the association between infection and cigarette smoking with a number of other diseases including Alzheimer’s and other neurodegenerative disorders. I also have recently initiated a program that focusses on investigating the interplay between iron, infection and immunity in lung and the effect this has on respiratory disease. 

Qualifications

  • Doctor of Philosophy, University of Newcastle
  • Bachelor of Biomedical Sciences (Hons), University of Newcastle

Keywords

  • Immunology
  • Pharmaceutical Sciences
  • Pharmacology

Fields of Research

Code Description Percentage
060599 Microbiology not elsewhere classified 15
111499 Paediatrics and Reproductive Medicine not elsewhere classified 15
110799 Immunology not elsewhere classified 70

Professional Experience

UON Appointment

Title Organisation / Department
Senior Lecturer University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Journal article (49 outputs)

Year Citation Altmetrics Link
2016 Kim RY, Rae B, Neal R, Donovan C, Pinkerton J, Balachandran L, et al., 'Elucidating novel disease mechanisms in severe asthma.', Clin Transl Immunology, 5 e91 (2016)
DOI 10.1038/cti.2016.37
Co-authors Malcolm Starkey, Philip Hansbro
2016 Simpson JL, Baines KJ, Horvat JC, Essilfie AT, Brown AC, Tooze M, et al., 'COPD is characterized by increased detection of Haemophilus influenzae, Streptococcus pneumoniae and a deficiency of Bacillus species', Respirology, 21 697-704 (2016) [C1]

© 2016 Asian Pacific Society of Respirology.Background and objective Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow limitation and inflammat... [more]

© 2016 Asian Pacific Society of Respirology.Background and objective Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow limitation and inflammation. Airway bacterial colonization is increased in COPD; however, the role of potentially pathogenic and non-pathogenic bacteria in the pathogenesis of disease is unclear. This study characterized the presence of bacteria in a well-characterized cohort of adults with COPD and healthy controls. Methods Adults with COPD (n = 70) and healthy controls (n = 51) underwent clinical assessment and sputum induction. Sputum was dispersed, and total and differential cell counts were performed. Bacteria were cultured, identified and enumerated. Supernatants were assessed for neutrophil elastase (NE) and IL-1ß. Common respiratory pathogens were also determined using real-time PCR. Results Participants with COPD had a typical neutrophilic inflammatory profile. The total load of bacteria was increased in COPD and was associated with poorer respiratory health status, as measured by the St George's Respiratory Questionnaire (Spearman's r = 0.336, P = 0.013). Significantly lower levels of culturable Bacillus species were identified compared with healthy controls. PCR analyses revealed increased rates of detection of potentially pathogenic bacteria with Haemophilus influenzae detection associated with higher sputum levels of NE and IL-1ß, while Streptococcus pneumoniae was more common in male ex-smokers with emphysema and a deficit in diffusion capacity. Conclusion Non-pathogenic and pathogenic bacteria were altered in the sputum of patients with COPD. These observations highlight the potential to identify treatment and management strategies that both target specific bacterial pathogens and restore the microbial balance, which may lead to reductions in inflammation and subsequent improvements in lung health.

DOI 10.1111/resp.12734
Citations Scopus - 1Web of Science - 1
Co-authors Katherine Baines, Philip Hansbro, Peter Gibson, Vanessa Mcdonald, Jodie Simpson
2016 Haw TJ, Starkey MR, Nair PM, Pavlidis S, Liu G, Nguyen DH, et al., 'A pathogenic role for tumor necrosis factor-related apoptosis-inducing ligand in chronic obstructive pulmonary disease', Mucosal Immunology, 9 859-872 (2016) [C1]

Chronic obstructive pulmonary disease (COPD) is a life-Threatening inflammatory respiratory disorder, often induced by cigarette smoke (CS) exposure. The development of effective ... [more]

Chronic obstructive pulmonary disease (COPD) is a life-Threatening inflammatory respiratory disorder, often induced by cigarette smoke (CS) exposure. The development of effective therapies is impaired by a lack of understanding of the underlining mechanisms. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a cytokine with inflammatory and apoptotic properties. We interrogated a mouse model of CS-induced experimental COPD and human tissues to identify a novel role for TRAIL in COPD pathogenesis. CS exposure of wild-Type mice increased TRAIL and its receptor messenger RNA (mRNA) expression and protein levels, as well as the number of TRAIL + CD11b + monocytes in the lung. TRAIL and its receptor mRNA were also increased in human COPD. CS-exposed TRAIL-deficient mice had decreased pulmonary inflammation, pro-inflammatory mediators, emphysema-like alveolar enlargement, and improved lung function. TRAIL-deficient mice also developed spontaneous small airway changes with increased epithelial cell thickness and collagen deposition, independent of CS exposure. Importantly, therapeutic neutralization of TRAIL, after the establishment of early-stage experimental COPD, reduced pulmonary inflammation, emphysema-like alveolar enlargement, and small airway changes. These data provide further evidence for TRAIL being a pivotal inflammatory factor in respiratory diseases, and the first preclinical evidence to suggest that therapeutic agents that target TRAIL may be effective in COPD therapy.

DOI 10.1038/mi.2015.111
Co-authors Joerg Mattes, Malcolm Starkey, Peter Wark, Philip Hansbro, Alan Hsu, Paul Foster, Darryl Knight, Adam Collison
2016 Starkey MR, Nguyen DH, Brown AC, Essilfie AT, Kim RY, Yagita H, et al., 'PD-L1 Promotes Early-life Chlamydia Respiratory Infection-induced Severe Allergic Airway Disease.', American journal of respiratory cell and molecular biology, (2016) [C1]
Citations Web of Science - 1
Co-authors Philip Hansbro, Malcolm Starkey
2016 Gang L, Hsu A, Cooley MA, Jarnicki AG, Nair PM, Haw TJ, et al., 'Fibulin-1 regulates the pathogenesis of tissue remodeling in respiratory diseases', Journal of Clinical Investigation Insight, 1 (2016)
DOI 10.1172/jci.insight.86380
Co-authors Philip Hansbro, Peter Wark, Alan Hsu, Marjorie Walker, Darryl Knight, Michael Fricker
2016 Starkey M, Nguyen D, Kim R, Haw T, Nair P, Essilfie A, et al., 'EARLY-LIFE RESPIRATORY BACTERIAL INFECTION-INDUCED CHRONIC LUNG DISEASE IS DRIVEN BY A NOVEL TLR2/IL-13/MIR-21/PI3K SIGNALLING PATHWAY', RESPIROLOGY, 21 37-37 (2016)
Co-authors Philip Hansbro
2016 Kim R, Pinkerton J, Essilfie A, Robertson A, Baines K, Mayall J, et al., 'NLRP3 INFLAMMASOME- MEDIATED, IL-1 beta-DEPENDENT INFLAMMATORY RESPONSES DRIVE SEVERE, STEROID-INSENSITIVE ASTHMA', RESPIROLOGY, 21 46-46 (2016)
Co-authors Philip Hansbro, Peter Gibson, Peter Wark
2016 Hansbro P, Brown A, Essilfie A, Beckett E, Thorburn A, Hansbro N, et al., 'PROGRAMMED DEATH-1 (PD-1) PREDISPOSES TO RESPIRATORY VIRAL INFECTION-INDUCED SECONDARY BACTERIAL PNEUMONIA', RESPIROLOGY, 21 58-58 (2016)
Co-authors Philip Hansbro
2016 Starkey M, Haw T, Pavlidis S, Nair MP, Liu G, Hanish I, et al., 'TOLL-LIKE RECEPTOR 7 PROMOTES CIGARETTE-SMOKE INDUCED EMPHYSEMA-LIKE ALVEOLAR ENLARGEMENT IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE', RESPIROLOGY, 21 79-79 (2016)
Co-authors Philip Hansbro
2016 Pinkerton J, Kim R, Essilfie A, Rae B, Mayall J, Ali M, et al., 'TARGETING OXIDATIVE STRESS FOR THE SUPPRESSION OF SEVERE, STEROID-INSENSITIVE ASTHMA', RESPIROLOGY, 21 105-105 (2016)
Co-authors Philip Hansbro
2016 Gold MJ, Hiebert PR, Park HY, Stefanowicz D, Le A, Starkey MR, et al., 'Mucosal production of uric acid by airway epithelial cells contributes to particulate matter-induced allergic sensitization.', Mucosal Immunol, 9 809-820 (2016)
DOI 10.1038/mi.2015.104
Citations Scopus - 2Web of Science - 1
Co-authors Malcolm Starkey, Philip Hansbro, Darryl Knight
2016 Hansbro P, Sunkara K, Jarnicki A, Kim R, Haw T, Wark P, et al., 'ROLE OF MIR-21 IN THE PATHOGENESIS OF EXPERIMENTAL COPD', RESPIROLOGY, 21 125-125 (2016)
Co-authors Philip Hansbro, Peter Wark
2015 Essilfie A, Horvat JC, Kim RY, Mayall JR, Pinkerton JW, Beckett EL, et al., 'Macrolide therapy suppresses key features of experimental steroid-sensitive and steroid-insensitive asthma', Thorax Journal, 70 458-467 (2015) [C1]
DOI 10.1136/thoraxjnl-2014-206067
Citations Scopus - 12Web of Science - 13
Co-authors Jodie Simpson, Paul Foster, Philip Hansbro, Peter Gibson, Malcolm Starkey
2015 Zouikr I, Ahmed AF, Horvat JC, Beagley KW, Clifton VL, Ray A, et al., 'Programming of formalin-induced nociception by neonatal LPS exposure: Maintenance by peripheral and central neuroimmune activity', Brain, Behavior, and Immunity, 44 235-246 (2015) [C1]

© 2014.The immune and nociceptive systems are shaped during the neonatal period where they undergo fine-tuning and maturation. Painful experiences during this sensitive period of... [more]

© 2014.The immune and nociceptive systems are shaped during the neonatal period where they undergo fine-tuning and maturation. Painful experiences during this sensitive period of development are known to produce long-lasting effects on the immune and nociceptive responses. It is less clear, however, whether inflammatory pain responses are primed by neonatal exposure to mild immunological stimuli, such as with lipopolysaccharide (LPS). Here, we examine the impact of neonatal LPS exposure on inflammatory pain responses, peripheral and hippocampal interleukin-1ß (IL-1ß), as well as mast cell number and degranulation in preadolescent and adult rats. Wistar rats were injected with LPS (0.05 mg/kg IP, Salmonella enteritidis) or saline on postnatal days (PNDs) 3 and 5 and later subjected to the formalin test at PNDs 22 and 80-97. At both time-points, and one-hour after formalin injection, blood and hippocampus were collected for measuring circulating and central IL-1ß levels using ELISA and Western blot, respectively. Paw tissue was also isolated to assess mast cell number and degree of degranulation using Toluidine Blue staining. Behavioural analyses indicate that at PND 22, LPS-challenged rats displayed enhanced flinching (p<.01) and licking (p<.01) in response to formalin injection. At PNDs 80-97, LPS-challenged rats exhibited increased flinching (p<.05), an effect observed in males only. Furthermore, neonatal LPS exposure enhanced circulating IL-1ß and mast cell degranulation in preadolescent but not adult rats following formalin injection. Hippocampal IL-1ß levels were increased in LPS-treated adult but not preadolescent rats in response to formalin injection. These data suggest neonatal LPS exposure produces developmentally regulated changes in formalin-induced behavioural responses, peripheral and central IL-1ß levels, as well as mast cell degranulation following noxious stimulation later in life. These findings highlight the importance of immune activation during the neonatal period in shaping immune response and pain sensitivity later in life. This is of clinical relevance given the high prevalence of bacterial infection during the neonatal period, particularly in the vulnerable population of preterm infants admitted to neonatal intensive care units.

DOI 10.1016/j.bbi.2014.10.014
Citations Scopus - 3Web of Science - 4
Co-authors Deborah Hodgson, Philip Hansbro, Rick Thorne
2015 Mateer SW, Maltby S, Marks E, Foster PS, Horvat JC, Hansbro PM, Keely S, 'Potential mechanisms regulating pulmonary pathology in inflammatory bowel disease.', J Leukoc Biol, 98 727-737 (2015) [C1]
DOI 10.1189/jlb.3RU1114-563R
Co-authors Steven Maltby, Simon Keely, Philip Hansbro, Paul Foster
2015 Kim RY, Horvat JC, Pinkerton JW, Starkey MR, Essilfie AT, Mayall JR, et al., 'MicroRNA-21 drives severe, steroid-insensitive experimental asthma by amplifying phosphoinositide 3-kinase-mediated suppression of histone deacetylase 2', Journal of Allergy and Clinical Immunology, (2015)

© 2016 American Academy of Allergy, Asthma & Immunology.Background: Severe steroid-insensitive asthma is a substantial clinical problem. Effective treatments are urgently require... [more]

© 2016 American Academy of Allergy, Asthma & Immunology.Background: Severe steroid-insensitive asthma is a substantial clinical problem. Effective treatments are urgently required, however, their development is hampered by a lack of understanding of the mechanisms of disease pathogenesis. Steroid-insensitive asthma is associated with respiratory tract infections and noneosinophilic endotypes, including neutrophilic forms of disease. However, steroid-insensitive patients with eosinophil-enriched inflammation have also been described. The mechanisms that underpin infection-induced, severe steroid-insensitive asthma can be elucidated by using mouse models of disease. Objective: We sought to develop representative mouse models of severe, steroid-insensitive asthma and to use them to identify pathogenic mechanisms and investigate new treatment approaches. Methods: Novel mouse models of . Chlamydia, . Haemophilus influenzae, influenza, and respiratory syncytial virus respiratory tract infections and ovalbumin-induced, severe, steroid-insensitive allergic airway disease (SSIAAD) in BALB/c mice were developed and interrogated. Results: Infection induced increases in the levels of microRNA (miRNA)-21 (miR-21) expression in the lung during SSIAAD, whereas expression of the miR-21 target phosphatase and tensin homolog was reduced. This was associated with an increase in levels of phosphorylated Akt, an indicator of phosphoinositide 3-kinase (PI3K) activity, and decreased nuclear histone deacetylase (HDAC)2 levels. Treatment with an miR-21-specific antagomir (Ant-21) increased phosphatase and tensin homolog levels. Treatment with Ant-21, or the pan-PI3K inhibitor LY294002, reduced PI3K activity and restored HDAC2 levels. This led to suppression of airway hyperresponsiveness and restored steroid sensitivity to allergic airway disease. These observations were replicated with SSIAAD associated with 4 different pathogens. Conclusion: We identify a previously unrecognized role for an miR-21/PI3K/HDAC2 axis in SSIAAD. Our data highlight miR-21 as a novel therapeutic target for the treatment of this form of asthma.

DOI 10.1016/j.jaci.2016.04.038
Co-authors Philip Hansbro, Simon Keely, Joerg Mattes, Malcolm Starkey, Paul Foster
2015 Sozo F, Horvat JC, Essilfie AT, O'Reilly M, Hansbro PM, Harding R, 'Altered lung function at mid-adulthood in mice following neonatal exposure to hyperoxia.', Respir Physiol Neurobiol, 218 21-27 (2015) [C1]
DOI 10.1016/j.resp.2015.07.004
Citations Scopus - 1Web of Science - 1
Co-authors Philip Hansbro
2015 Singanayagam A, Glanville N, Walton RP, Aniscenko J, Pearson RM, Pinkerton JW, et al., 'A short-term mouse model that reproduces the immunopathological features of rhinovirus-induced exacerbation of COPD.', Clin Sci (Lond), 129 245-258 (2015) [C1]
DOI 10.1042/CS20140654
Citations Scopus - 4Web of Science - 3
Co-authors Nathan Bartlett, Philip Hansbro
2015 Kim RY, Pinkerton JW, Gibson PG, Cooper MA, Horvat JC, Hansbro PM, 'Inflammasomes in COPD and neutrophilic asthma', THORAX, 70 1199-1201 (2015) [C1]
DOI 10.1136/thoraxjnl-2014-206736
Citations Scopus - 1Web of Science - 2
Co-authors Philip Hansbro, Peter Gibson
2014 Starkey MR, Nguyen DH, Essilfie AT, Kim RY, Hatchwell LM, Collison AM, et al., 'Tumor necrosis factor-related apoptosis-inducing ligand translates neonatal respiratory infection into chronic lung disease.', Mucosal Immunol, 7 478-488 (2014) [C1]
DOI 10.1038/mi.2013.65
Citations Scopus - 4Web of Science - 2
Co-authors Philip Hansbro, Adam Collison, Malcolm Starkey, Paul Foster, Joerg Mattes
2014 O'Reilly M, Hansbro PM, Horvat JC, Beckett EL, Harding R, Sozo F, 'Bronchiolar Remodeling in Adult Mice Following Neonatal Exposure to Hyperoxia: Relation to Growth', Anatomical Record, 297 758-769 (2014) [C1]

Preterm infants who receive supplemental oxygen for prolonged periods are at increased risk of impaired lung function later in life. This suggests that neonatal hyperoxia induces ... [more]

Preterm infants who receive supplemental oxygen for prolonged periods are at increased risk of impaired lung function later in life. This suggests that neonatal hyperoxia induces persistent changes in small conducting airways (bronchioles). Although the effects of neonatal hyperoxia on alveolarization are well documented, little is known about its effects on developing bronchioles. We hypothesized that neonatal hyperoxia would remodel the bronchiolar walls, contributing to altered lung function in adulthood. We studied three groups of mice (C57BL/6J) to postnatal day 56 (P56; adulthood) when they either underwent lung function testing or necropsy for histological analysis of the bronchiolar wall. One group inhaled 65% O2 from birth until P7, after which they breathed room air; this group experienced growth restriction (HE+GR group). We also used a group in which hyperoxia-induced GR was prevented by dam rotation (HE group). A control group inhaled room air from birth. At P56, the bronchiolar epithelium of HE mice contained fewer Clara cells and more ciliated cells, and the bronchiolar wall contained ~25% less collagen than controls; in HE+GR mice the bronchiolar walls had ~13% more collagen than controls. Male HE and HE+GR mice had significantly thicker bronchiolar epithelium than control males and altered lung function (HE males: greater dynamic compliance; HE+GR males: lower dynamic compliance). We conclude that neonatal hyperoxia remodels the bronchiolar wall and, in adult males, affects lung function, but effects are altered by concomitant growth restriction. Our findings may partly explain the reports of poor lung function in ex-preterm children and adults. Anat Rec, 297:758-769, 2014. © 2014 Wiley Periodicals, Inc.

DOI 10.1002/ar.22867
Citations Scopus - 6Web of Science - 7
Co-authors Philip Hansbro
2014 Hansbro PM, Starkey MR, Mattes J, Horvat JC, 'Pulmonary immunity during respiratory infections in early life and the development of severe asthma', Annals of the American Thoracic Society, 11 S297-S302 (2014) [C1]

Copyright © 2014 by the American Thoracic SocietyAsthma affects 10% of the population in Westernized countries, being most common in children. It is a heterogeneous condition cha... [more]

Copyright © 2014 by the American Thoracic SocietyAsthma affects 10% of the population in Westernized countries, being most common in children. It is a heterogeneous condition characterized by chronic allergic airway inflammation, mucus hypersecretion, and airway hyperresponsiveness (AHR) to normally innocuous antigens. Combination therapies with inhaled corticosteroids and bronchodilators effectively manage mild to moderate asthma, but there are no cures, and patients with severe asthma do not respond to these treatments. The inception of asthma is linked to respiratory viral (respiratory syncytial virus, rhinovirus) and bacterial (Chlamydia, Mycoplasma) infections. The examination of mouse models of early-life infections and allergic airway disease (AAD) provides valuable insights into the mechanisms of disease inception that may lead to the development of more effective therapeutics. For example, early-life, but not adult, Chlamydia respiratory infections in mice permanently modify immunity and lung physiology. This increases the severity of AAD by promoting IL-13 expression, mucus hypersecretion, and AHR. We have identified novel roles for tumor necrosis factor-related apoptosisinducing ligand (TRAIL) and IL-13 in promoting infection-induced pathology in early life and subsequent chronic lung disease. Genetic deletion of TRAIL or IL-13 variously protected against neonatal infection-induced inflammation, mucus hypersecretion, altered lung structure, AHR, and impaired lung function. Therapeutic neutralization of these factors prevented infection-induced severe AAD. Other novel mechanisms and avenues for intervention are also being explored. Such studies indicate the immunological mechanisms that may underpin the association between early-life respiratory infections and the development of more severe asthma and may facilitate the development of tailored preventions and treatments.

DOI 10.1513/AnnalsATS.201402-086AW
Citations Scopus - 2
Co-authors Malcolm Starkey, Philip Hansbro, Joerg Mattes
2014 Goggins B, Minahan K, Kostakis A, Shalwitz R, Horvat J, Keely S, 'Stabilisation of epithelial hypoxia-inducible factor reverses colitis through accelerated restitution', FASEB JOURNAL, 28 (2014)
Co-authors Simon Keely
2013 Goggins BJ, Chaney C, Radford-Smith GL, Horvat JC, Keely S, 'Hypoxia and Integrin-Mediated Epithelial Restitution during Mucosal Inflammation.', Front Immunol, 4 272 (2013) [C1]
DOI 10.3389/fimmu.2013.00272
Citations Scopus - 14Web of Science - 12
Co-authors Simon Keely
2013 Starkey MR, Nguyen DH, Kim RY, Nair PM, Brown AC, Essifie A-T, et al., 'Programming of the Lung in Early Life by Bacterial Infections Predisposes to Chronic Respiratory Disease', CLINICAL OBSTETRICS AND GYNECOLOGY, 56 566-576 (2013) [C1]
DOI 10.1097/GRF.0b013e3182993a0c
Citations Scopus - 4Web of Science - 3
Co-authors Malcolm Starkey, Philip Hansbro
2013 Hansbro P, Beckett E, Stevens R, Jarnicki A, Wark P, Foster P, 'A short-term model of COPD identifies a role for mast cell tryptase', EUROPEAN RESPIRATORY JOURNAL, 42 (2013)
Co-authors Paul Foster, Philip Hansbro, Peter Wark, Simon Keely
2013 Fung KY, Mangan NE, Cumming H, Horvat JC, Mayall JR, Stifter SA, et al., 'Interferon-epsilon Protects the Female Reproductive Tract from Viral and Bacterial Infection', SCIENCE, 339 1088-1092 (2013) [C1]
DOI 10.1126/science.1233321
Citations Scopus - 39Web of Science - 44
Co-authors Philip Hansbro
2013 Beckett EL, Stevens RL, Jarnicki AG, Kim RY, Hanish I, Hansbro NG, et al., 'A new short-term mouse model of chronic obstructive pulmonary disease identifies a role for mast cell tryptase in pathogenesis', The Journal of Allergy and Clinical Immunology, 131 752-762 (2013) [C1]
Citations Scopus - 50Web of Science - 50
Co-authors Ming Yang, Philip Hansbro, Nicole Hansbro, Simon Keely, Paul Foster, Peter Wark
2013 Hansbro PM, Scott GV, Essilfie A-T, Kim RY, Starkey MR, Nguyen D, et al., 'Th2 cytokine antagonists: Potential treatments for severe asthma', Expert Opinion on Investigational Drugs, 22 49-69 (2013) [C1]
Citations Scopus - 22Web of Science - 17
Co-authors Paul Foster, Philip Hansbro, Ming Yang, Malcolm Starkey
2013 Starkey MR, Jarnicki AG, Essilfie A-T, Gellatly SL, Kim RY, Brown AC, et al., 'Murine models of infectious exacerbations of airway inflammation', CURRENT OPINION IN PHARMACOLOGY, 13 337-344 (2013) [C1]
DOI 10.1016/j.coph.2013.03.005
Citations Scopus - 15Web of Science - 13
Co-authors Philip Hansbro, Paul Foster, Malcolm Starkey
2013 Starkey MR, Essilfie A-T, Horvat JC, Kim RY, Nguyen DH, Beagley KW, et al., 'Constitutive production of IL-13 promotes early-life Chlamydia respiratory infection and allergic airway disease', Mucosal Immunology, 6 569-579 (2013) [C1]
Citations Scopus - 12Web of Science - 9
Co-authors Malcolm Starkey, Philip Hansbro, Joerg Mattes, Paul Foster
2012 Wynne OL, Horvat JC, Smith R, Hansbro PM, Clifton VL, Hodgson DM, 'Effect of neonatal respiratory infection on adult BALB/c hippocampal glucocorticoid and mineralocorticoid receptors', Developmental Psychobiology, 54 568-575 (2012) [C1]
Citations Scopus - 2Web of Science - 2
Co-authors Vicki Clifton, Deborah Hodgson, Philip Hansbro, Roger Smith, Olivia Wynne
2012 Beckett EL, Phipps S, Starkey MR, Horvat JC, Beagley KW, Foster PS, Hansbro PM, 'TLR2, but not TLR4, is required for effective host defence against chlamydia respiratory tract infection in early life', PLOS One, 7 e39460 (2012) [C1]
Citations Scopus - 25Web of Science - 21
Co-authors Paul Foster, Philip Hansbro, Malcolm Starkey
2012 Starkey MR, Kim RY, Beckett EL, Schilter HC, Shim D, Essilfie A-T, et al., 'Chlamydia muridarum lung infection in infants alters hematopoietic cells to promote allergic airway disease in mice', PLoS One, 7 e42588 (2012) [C1]
Citations Scopus - 10Web of Science - 9
Co-authors Philip Hansbro, Malcolm Starkey, Joerg Mattes
2012 Hansbro PM, Starkey MR, Kim RY, Stevens RL, Foster PS, Horvat JC, 'Programming of the lung by early-life infection', Journal of Developmental Origins of Health and Disease, 3 153-158 (2012) [C1]
Citations Scopus - 7Web of Science - 5
Co-authors Paul Foster, Malcolm Starkey, Philip Hansbro
2011 Essilfie A-T, Simpson JL, Horvat JC, Preston JA, Dunkley ML, Foster PS, et al., 'Haemophilus influenzae infection drives IL-17-mediated neutrophilic allergic airways disease', PLoS Pathogens, 7 e1002244 (2011) [C1]
Co-authors Margaret Dunkley, Philip Hansbro, Jodie Simpson, Peter Gibson, Paul Foster
2011 Asquith KL, Horvat JC, Kaiko GE, Carey AJ, Beagley KW, Hansbro PM, Foster PS, 'Interleukin-13 promotes susceptibility to chlamydial infection of the respiratory and genital tracts', PLoS Pathogens, 7 e1001339 (2011) [C1]
Citations Scopus - 30Web of Science - 27
Co-authors Philip Hansbro, Paul Foster
2011 Wynne OL, Horvat JC, Kim RY, Ong LK, Smith R, Hansbro PM, et al., 'Neonatal respiratory infection and adult re-infection: Effect on glucocorticoid and mineralocorticoid receptors in the hippocampus in BALB/c mice', Brain Behavior and Immunity, 25 1214-1222 (2011) [C1]
DOI 10.1016/j.bbi.2011.03.014
Citations Scopus - 3Web of Science - 3
Co-authors Vicki Clifton, Olivia Wynne, Linkooi Ong, Deborah Hodgson, Roger Smith, Philip Hansbro
2011 Preston JA, Thorburn AN, Starkey MR, Beckett EL, Horvat JC, Wade MA, et al., 'Streptococcus pneumoniae infection suppresses allergic airways disease by inducing regulatory T-cells', European Respiratory Journal, 37 53-64 (2011) [C1]
DOI 10.1183/09031936.00049510
Citations Scopus - 37Web of Science - 33
Co-authors Paul Foster, Peter Gibson, Malcolm Starkey, Philip Hansbro
2011 Wynne OL, Horvat JC, Osei-Kumah A, Smith R, Hansbro PM, Clifton VL, Hodgson DM, 'Early life infection alters adult BALB/c hippocampal gene expression in a sex specific manner', Stress-the International Journal on the Biology of Stress, 14 247-261 (2011) [C1]
DOI 10.3109/10253890.2010.532576
Citations Scopus - 9Web of Science - 9
Co-authors Roger Smith, Philip Hansbro, Vicki Clifton, Deborah Hodgson, Olivia Wynne
2010 Horvat JC, Starkey MR, Kim RY, Beagley KW, Preston JA, Gibson PG, et al., 'Chlamydial respiratory infection during allergen sensitization drives neutrophilic allergic airways disease', Journal of Immunology, 184 4159-4169 (2010) [C1]
DOI 10.4049/jimmunol.0902287
Citations Scopus - 45Web of Science - 42
Co-authors Malcolm Starkey, Philip Hansbro, Peter Gibson, Paul Foster
2010 Horvat JC, Starkey MR, Kim RY, Phipps S, Gibson PG, Beagley KW, et al., 'Early-life chlamydial lung infection enhances allergic airways disease through age-dependent differences in immunopathology', Journal of Allergy and Clinical Immunology, 125 617-625 (2010) [C1]
DOI 10.1016/j.jaci.2009.10.018
Co-authors Malcolm Starkey, Philip Hansbro, Peter Gibson, Paul Foster
2010 Starkey MR, Horvat JC, Kim RY, Hansbro PM, 'Reply', Journal of Allergy and Clinical Immunology, 125 1415 (2010) [C3]
DOI 10.1016/j.jaci.2010.03.033
Co-authors Malcolm Starkey, Philip Hansbro
2008 Kaiko GE, Horvat JC, Beagley KW, Hansbro PM, 'Immunological decision-making: How does the immune system decide to mount a helper T-cell response?', Immunology, 123 326-338 (2008) [C1]
DOI 10.1111/j.1365-2567.2007.02719.x
Citations Scopus - 145Web of Science - 131
Co-authors Philip Hansbro
2008 Hansbro NG, Horvat JC, Wark PA, Hansbro PM, 'Understanding the mechanisms of viral induced asthma: New therapeutic directions', Pharmacology & Therapeutics, 117 313-353 (2008) [C1]
DOI 10.1016/j.pharmthera.2007.11.002
Citations Scopus - 63Web of Science - 53
Co-authors Philip Hansbro, Peter Wark, Nicole Hansbro
2007 Horvat JC, Beagley KW, Wade MA, Preston JA, Hansbro NG, Hickey DK, et al., 'Neonatal chlamydial infection induces mixed T-cell responses that drive allergic airway disease', American Journal of Respiratory and Critical Care Medicine, 176 556-564 (2007) [C1]
DOI 10.1164/rccm.200607-1005OC
Citations Scopus - 51Web of Science - 48
Co-authors Nicole Hansbro, Peter Gibson, Paul Foster, Philip Hansbro
2007 Preston JA, Essilfie AT, Horvat JC, Wade MA, Beagley KW, Gibson PG, et al., 'Inhibition of allergic airways disease by immunomodulatory therapy with whole killed Streptococcus pneumoniae', Vaccine, 25 8154-8162 (2007) [C1]
DOI 10.1016/j.vaccine.2007.09.034
Citations Scopus - 30Web of Science - 29
Co-authors Peter Gibson, Paul Foster, Philip Hansbro
2006 Skelding KA, Hickey DK, Horvat JC, Bao SS, Roberts KG, Read JM, et al., 'Comparison of intranasal and transcutaneous immunization for induction of protective immunity against Chlamydia muridarum respiratory tract infection', Vaccine, 24 355-366 (2006) [C1]
DOI 10.1016/j.vaccine.2005.07.104
Citations Scopus - 29Web of Science - 26
Co-authors Kathryn Skelding, Philip Hansbro
2004 Hansbro PM, Beagley KW, Horvat JC, Gibson PG, 'Role of atypical bacterial infection of the lung in predisposition/protection of asthma', Pharmacology and Therapeutics, 101 193-210 (2004) [C1]
DOI 10.1016/j.pharmthera.2003.10.007
Citations Scopus - 66Web of Science - 57
Co-authors Philip Hansbro, Peter Gibson
Show 46 more journal articles

Conference (62 outputs)

Year Citation Altmetrics Link
2016 Horvat J, Kim R, Pinkerton J, Rae B, Starkey M, Essilfie A, et al., 'IDENTIFICATION OF NOVEL THERAPEUTIC TARGETS FOR STEROID-INSENSITIVE ASTHMA USING MODELS THAT REPRESENT DIFFERENT CLINICAL SUBTYPES OF DISEASE', RESPIROLOGY (2016)
Co-authors Joerg Mattes, Simon Keely, Philip Hansbro
2015 Kim R, Horvat J, Pinkerton J, Starkey M, Essilfie A, Mayall J, et al., 'INFECTION-INDUCED MICRORNA-21 DRIVES SEVERE, STEROID-INSENSITIVE EXPERIMENTAL ASTHMA BY AMPLIFYING PI3K-MEDIATED SUPPRESSION OF HDAC2', RESPIROLOGY (2015) [E3]
Co-authors Joerg Mattes, Paul Foster, Philip Hansbro, Malcolm Starkey, Simon Keely
2015 Mateer S, Marks E, Maltby S, Goggins B, Horvat J, Hansbro P, Keely S, 'Pulmonary retention of PMN attracts primed intestinal lymphocytes in a mouse model of inflammatory bowel disease', FASEB JOURNAL (2015) [E3]
Co-authors Philip Hansbro, Steven Maltby, Simon Keely
2015 Hansbro P, Kim R, Pinkerton J, Starkey M, Essilfie A-T, Mayall J, et al., 'MicroRNA-21 drives severe, steroid-insensitive experimental asthma by amplifying PI3K-mediated suppression of HDAC2', JOURNAL OF IMMUNOLOGY (2015)
Co-authors Joerg Mattes, Paul Foster, Philip Hansbro
2015 Essilfie A-T, Horvat J, Kim R, Mayall J, Pinkerton J, Beckett E, et al., 'Macrolide therapy suppresses key features of experimental steroid-sensitive and steroid insensitive asthma', JOURNAL OF IMMUNOLOGY (2015)
Co-authors Paul Foster, Jodie Simpson, Philip Hansbro
2015 Hansbro P, Haw T, Nair P, Hanish I, Nguyen D, Liu G, et al., 'Tumour necrosis factor-related apoptosis inducing ligand promotes the development of experimental chronic obstructive pulmonary disease', JOURNAL OF IMMUNOLOGY (2015)
Co-authors Adam Collison, Philip Hansbro, Joerg Mattes
2015 Hansbro P, Mayall J, Mangan N, Starkey M, Kim R, Hertzog P, Horvat J, 'Role of NK cells in IFN-epsilon-mediated protection against female reproductive tract infection', JOURNAL OF IMMUNOLOGY (2015)
Co-authors Philip Hansbro
2015 Hansbro PM, Kim RY, Pinkerton JW, Starkey MR, Essilfie AT, Mayall JR, et al., 'Infection-Induced Microrna-21 Drives Severe, Steroid-Insensitive Experimental Asthma By Amplifying PhosphoINOSitide-3-Kinase (pi3k)-Mediated Suppression Of Histone Deacetylase (hdac)2', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2015)
Co-authors Malcolm Starkey, Philip Hansbro, Joerg Mattes, Paul Foster
2014 Goggins B, Minahan K, Marks E, Mateer S, Cardona J, Knight D, et al., 'Hypoxia inducible factor (HIF)-1 accelerates epithelial wound healing through integrin regulation', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2014) [E3]
Co-authors Simon Keely, Darryl Knight
2014 Cardona J, Marks E, Goggins B, Mateer S, Minahan K, Horvat J, Keely S, 'The role of antibiotics in the development of food allergy', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2014) [E3]
Co-authors Simon Keely
2014 Mateer S, Maltby S, Marks E, Goggins B, Horvat J, Hansbro P, Keely S, 'Immune cell mis-homing drives secondary organ inflammation in inflammatory bowel disease; a focus on the respiratory system', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2014) [E3]
Co-authors Philip Hansbro, Steven Maltby, Simon Keely
2014 Starkey M, Hanish I, Dua K, Nair P, Haw T, Hsu A, et al., 'Interleukin-13 predisposes mice to more severe influenza infection by suppressing interferon responses and activating microRNA-21/PI3K', CYTOKINE (2014) [E3]
DOI 10.1016/j.cyto2014.07.182
Co-authors Malcolm Starkey, Philip Hansbro, Darryl Knight, Alan Hsu, Paul Foster, Peter Wark
2014 Horvat J, Kim R, Mayall J, Pinkerton J, Starkey M, Essilfie A, et al., 'ANTIOXIDANT-BASED THERAPY FOR THE SUPPRESSION OF EARLY- LIFE INFECTION-INDUCED SEVERE ASTHMA', RESPIROLOGY (2014) [E3]
DOI 10.1111/resp.12263_2
Co-authors Lisa Wood, Malcolm Starkey, Philip Hansbro
2013 Hansbro P, Beckett E, Stevens R, Jarnicki A, Kim R, Hanish I, et al., 'A short-term model of COPD identifies a role for mast cell tryptase', JOURNAL OF IMMUNOLOGY (2013) [E3]
Co-authors Paul Foster, Simon Keely, Nicole Hansbro, Peter Wark, Ming Yang, Philip Hansbro
2013 Hansbro P, Horvat J, Essilfie A-T, Kim R, Mayall J, Starkey M, Foster P, 'Macrolides suppress key features of experimental steroid-sensitive and steroid-resistant asthma', JOURNAL OF IMMUNOLOGY (2013) [E3]
Co-authors Paul Foster, Philip Hansbro, Malcolm Starkey
2013 Kim RY, Horvat JC, Starkey MR, Essilfie A-T, Foster PS, Hansbro PM, 'MICRORNA INHIBITION IN NEONATAL CHLAMYDIA LUNG INFECTION PREVENTS INFECTION-INDUCED LUNG PATHOLOGY IN LATER LIFE', RESPIROLOGY (2013) [E3]
Co-authors Philip Hansbro, Paul Foster, Malcolm Starkey
2013 Horvat JC, Essilfie A-T, Kim RY, Mayall JR, Starkey MR, Beckett EL, et al., 'MACROLIDES SUPPRESS KEY FEATURES OF EXPERIMENTAL STEROID-SENSITIVE AND STEROID-RESISTANT ASTHMA', RESPIROLOGY (2013) [E3]
Co-authors Paul Foster, Jodie Simpson, Malcolm Starkey, Peter Gibson, Philip Hansbro
2012 Stifter SA, Fung K, Horvat JC, Hansbro PM, De Weerd NA, Hertzog PJ, 'Expression, purification and biological characterisation of a novel type I interferon, IFN epsilon', Immunology (2012) [E3]
Co-authors Philip Hansbro
2012 Starkey M, Kim R, Horvat J, Essilfie A-T, Beagley K, Mattes J, et al., 'Constitutive IL-13 promotes respiratory chlamydial infection and infection-induced chronic airway hyper-responsiveness', JOURNAL OF IMMUNOLOGY (2012) [E3]
Co-authors Philip Hansbro, Joerg Mattes, Paul Foster
2012 Horvat JC, Essilfie A-T, Kim RY, Mayall JR, Starkey MR, Beckett EL, et al., 'Efficacy of antibiotic-based therapeutic strategies for the treatment of infection-induced, steroid-resistant allergic airways disease', Respirology (2012) [E3]
Co-authors Paul Foster, Philip Hansbro, Malcolm Starkey
2012 Starkey MR, Kim RY, Horvat JC, Essilfie A-T, Beagley KW, Mattes J, et al., 'Constitutive IL-13 promotes respiratory chlamydial infection-induced chronic airway hyperresponsiveness', Respirology (2012) [E3]
Co-authors Paul Foster, Philip Hansbro, Joerg Mattes, Malcolm Starkey
2011 O'Reilly M, Hansbro PM, Horvat JC, Sozo F, Harding R, 'Inhalation of hyperoxic gas in the neonatal period has long-term effects on the pulmonary airways', Journal of Developmental Origins of Health and Disease (2011) [E3]
Co-authors Philip Hansbro
2011 Wynnea O, Horvat JC, Kim RY, Ong LK, Smith R, Hansbro PM, et al., 'Sex differences in the effect of neonatal infection and adult re-infection on hippocampal corticosterone receptors and stress response outcomes', Brain, Behavior, and Immunity (2011) [E3]
Co-authors Deborah Hodgson, Philip Hansbro, Roger Smith, Linkooi Ong
2011 Hansbro PM, Horvat JC, Essilfie A-T, Kim RY, Simpson JL, Dunkley ML, et al., 'Infection-induced neutrophilic allergic airways disease is resistant to steroid treatment', American Journal of Respiratory and Critical Care Medicine (2011) [E3]
Co-authors Margaret Dunkley, Philip Hansbro, Jodie Simpson, Peter Gibson, Paul Foster
2011 Horvat JC, Essilfie A-T, Kim RY, Simpson JL, Dunkley ML, Beagley KW, et al., 'Investigation of infection-induced steroid resistant asthma', Respirology (2011) [E3]
Co-authors Margaret Dunkley, Philip Hansbro, Jodie Simpson, Paul Foster, Peter Gibson
2010 Hansbro PM, Essilfie A-T, Simpson JL, Dunkley ML, Horvat JC, Gibson PG, Foster PS, 'Haemophilus influenzae induces IL-17-mediated neutrophilic allergic airways disease', American Journal of Respiratory and Critical Care Medicine (2010) [E3]
Citations Scopus - 54Web of Science - 47
Co-authors Jodie Simpson, Philip Hansbro, Paul Foster, Margaret Dunkley, Peter Gibson
2010 O'Reilly M, Harding R, Beckett EL, Horvat JC, Hansbro PM, Sozo F, 'Exposure of the immature mouse lung to hyperoxic gas: do structural changes in the lung cause long-term changes in lung function?', 24th Fetal and Neonatal Physiology Workshop of Australia and New Zealand. Program and Abstracts (2010) [E3]
Co-authors Philip Hansbro
2010 Fung K, Cumming H, Mangan N, Horvat JC, Hansbro PM, Hertzog P, 'Interferon epsilon regulates reproductive tract immunity to Chlamydia infection', Journal of Reproductive Immunology (2010) [E3]
Co-authors Philip Hansbro
2009 Fung KY, Cumming H, Mangan N, Stifter S, Horvat JC, Hansbro PM, Hertzog PJ, 'Characterisation of a novel, constitutive cytokine that regulates mucosal immunity in the reproductive tract', Cytokine (2009) [E3]
DOI 10.1016/j.cyto.2009.07.324
Co-authors Philip Hansbro
2009 Hansbro PM, Starkey MR, Horvat JC, Kim RY, Phipps S, Gibson PG, Foster PS, 'Early life chlamydial infection enhances allergic airways disease through age-dependent differences in immunopathology', Journal of Immunology (2009) [E3]
DOI 10.1016/j.jaci.2009.10.018
Co-authors Malcolm Starkey, Philip Hansbro, Peter Gibson, Paul Foster
2009 Horvat JC, Starkey MR, Beagley KW, Gibson PG, Foster PS, Hansbro PM, 'Chlamydial respiratory infection predisposes to neutrophil dominated allergic airways disease (AAD)', Journal of Immunology (2009) [E3]
Co-authors Malcolm Starkey, Philip Hansbro, Peter Gibson, Paul Foster
2009 Horvat JC, Starkey MR, Beagley KW, Preston JA, Gibson PG, Foster PS, Hansbro PM, 'Neutrophil influx during chlamydial lung infection determines the phenotype of allergic airways disease (AAD)', Respirology (2009) [E3]
DOI 10.1111/j.1440-1843.2009.01503_1.x
Co-authors Philip Hansbro, Malcolm Starkey, Paul Foster, Peter Gibson
2009 Starkey MR, Horvat JC, Kim RY, Phipps S, Gibson PG, Beagley KW, et al., 'Early life chlamydial lung infection enhances allergic airways disease through age-dependent differences in immunopathology', Respirology (2009) [E3]
DOI 10.1016/j.jaci.2009.10.018
Citations Scopus - 54Web of Science - 53
Co-authors Philip Hansbro, Paul Foster, Peter Gibson, Malcolm Starkey
2008 Wynne OL, Horvat JC, Smith R, Hansbro PM, Clifton VL, Hodgson DM, 'Impact of neonatal infection on adult hippocampal glucocorticoid receptor, mineralocorticoid receptor and corticotrophin releasing hormone mRNA abundance', Proceedings of the Australian Neuroscience Society (2008) [E3]
Co-authors Roger Smith, Philip Hansbro, Deborah Hodgson, Olivia Wynne, Vicki Clifton
2008 Hansbro PM, Horvat JC, Beagley KW, Gibson PG, Foster PS, 'Neutrophil influx during chlamydial lung infection determines the phenotype of allergic airways disease', American Journal of Respiratory and Critical Care Medicine (2008) [E3]
Co-authors Paul Foster, Philip Hansbro, Peter Gibson
2008 Horvat JC, Beagley KW, Gibson PG, Foster PS, Hansbro PM, 'Neutrophil influx during chlamydial lung infection determines the phenotype of allergic airways disease', Respirology (2008) [E3]
DOI 10.1111/j.1440-1843.2008.01252.x
Co-authors Peter Gibson, Paul Foster, Philip Hansbro
2008 Essilfie A-T, Preston JA, Horvat JC, Dunkley ML, Foster PS, Gibson PG, et al., 'Haemophilus influenzae (Hi) infection in asthma may drive the development of neutrophilic asthma (NA)', Respirology (2008) [E3]
DOI 10.1111/j.1440-1843.2008.01252.x
Co-authors Paul Foster, Margaret Dunkley, Philip Hansbro, Jodie Simpson, Peter Gibson
2008 Wynne OL, Horvat JC, Smith R, Hansbro PM, Clifton VL, Hodgson DM, 'Impact of neonatal infection on adult hippocampal glucocorticoid receptor and mineralocorticoid receptor abundance', 15th Annual Meeting of the Psychoneuroimmunology Research Society: Program (2008) [E3]
Co-authors Olivia Wynne, Philip Hansbro, Roger Smith, Vicki Clifton, Deborah Hodgson
2008 Starkey MR, Horvat JC, Kim RY, Phipps S, Gibson PG, Beagley KW, et al., 'Early life chlamydial lung infection enhances allergic airways disease through age-dependent differences in immunopathology', Australasian Society for Immunology 38th Annual Scientific Meeting: Delegate Book (2008) [E3]
Co-authors Peter Gibson, Philip Hansbro, Malcolm Starkey, Paul Foster
2007 Horvat JC, Preston JA, Gibson PG, Beagley KW, Foster PS, Hansbro PM, 'Development of allergic airways disease (AAD) is differentially affected by the timing of chlamydial infection relative to allergic sensitization', American Journal of Respiratory and Critical Care Medicine (2007) [E3]
Co-authors Paul Foster, Philip Hansbro, Peter Gibson
2007 Horvat JC, Garside CG, Wade MA, Preston JA, Hansbro NG, Gibson PG, et al., 'Development of allergic airways disease is differentially affected by chlamydial respiratory infection at different ages', American Journal of Respiratory and Critical Care Medicine (2007) [E3]
Co-authors Paul Foster, Peter Gibson, Nicole Hansbro, Philip Hansbro
2007 Wynne OL, Horvat JC, Smith R, Hansbro PM, Clifton VL, Hodgson DM, 'Impact of neonatal infection on adult hippocampal corticosterone receptor abundance and circulating corticosterone', Early Human Development (2007) [E3]
Co-authors Vicki Clifton, Olivia Wynne, Roger Smith, Deborah Hodgson, Philip Hansbro
2007 Wynne OL, Horvat JC, Hansbro PM, Clifton VL, Hodgson DM, 'Impact of postnatal stress on neuroendocrine development and function in adulthood in the mouse', Fetal & Neonatal Workshop of Australia and New Zealand 21st Annual Meeting. Abstracts (2007) [E3]
Co-authors Vicki Clifton, Deborah Hodgson, Olivia Wynne, Philip Hansbro
2007 Essiflie A, Preston JA, Horvat JC, Dunkley ML, Foster PS, Gibson PG, et al., 'Elucidating the association between Haemophilus influenzae infection and neutrophilic allergic airways disease using mouse models', Immuno 2007: 13th International Congress of Immunology. Abstracts and Posters (2007) [E3]
Co-authors Margaret Dunkley, Philip Hansbro, Peter Gibson, Paul Foster, Jodie Simpson
2007 Horvat JC, Moller CG, Wade MA, Preston JA, Hansbro NG, Gibson PG, et al., 'Allergic airways disease (AAD) is differentially affected by chlamydial lung infection at different stages of life', Respirology (TSANZ Abstracts-Posters) (2007) [E3]
DOI 10.1111/j.1440-1843.2007.001050.x
Co-authors Paul Foster, Philip Hansbro, Peter Gibson, Nicole Hansbro
2007 Horvat JC, Preston JA, Gibson PG, Beagley KW, Foster PS, Hansbro PM, 'Timing of chlamydial infection relative to allergen exposure differentially affects allergic airways disease', Respirology (TSANZ Abstracts-Posters) (2007) [E3]
Co-authors Peter Gibson, Philip Hansbro, Paul Foster
2006 Horvat JC, Preston JA, Gibson PG, Beagley KW, Foster PS, Hansbro PM, 'Exacerbation of Allergic Airways Disease (AAD) by Chlamydia is Differentially Affected by the Timing of Infection Relative to Allergen Exposure', Immunology and Cell Biology (2006) [E3]
Co-authors Peter Gibson, Philip Hansbro, Paul Foster
2006 Preston JA, Horvat JC, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'Streptococcus pneumoniae (SPN) lung infection suppresses hallmark features of a mouse model of asthma', Immunology and Cell Biology (2006) [E3]
Co-authors Peter Gibson, Paul Foster, Philip Hansbro
2006 Horvat JC, Moller CG, Wade MA, Preston JA, Hansbro NG, Gibson PG, et al., 'The development of allergic airways disease (AAD) is differently affected by chlamydial lung infection at different stages of life', Immunology and Cell Biology (2006) [E3]
Co-authors Nicole Hansbro, Philip Hansbro, Peter Gibson, Paul Foster
2006 Horvat JC, Wade MA, Preston JA, Hansbro NG, Gibson PG, Beagley KW, et al., 'Early life chlamydial lung infection enhances allergic airways disease (AAD)', Respirology (2006) [E3]
Co-authors Paul Foster, Peter Gibson, Nicole Hansbro, Philip Hansbro
2006 Preston JA, Horvat JC, Wade MA, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'Inhibition of allergic lung disease by respiratory streptococcus pneumoniae infection', Respirology (2006) [E3]
Co-authors Philip Hansbro, Peter Gibson, Paul Foster
2006 Horvat JC, Wade MA, Preston JA, Hansbro NG, Gibson PG, Beagley KW, et al., 'Neonatal chlamydial infection exacerbates allergic airways disease', Abstracts ATS 2006 International Conference (2006) [E3]
Co-authors Philip Hansbro, Nicole Hansbro, Paul Foster, Peter Gibson
2006 Preston JA, Horvat JC, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'Respiratory Streptococcus pneumoniae infection decreases key inflammatory responses in a mouse model of asthma', Abstracts ATS 2006 International Conference (2006) [E3]
Co-authors Philip Hansbro, Peter Gibson, Paul Foster
2006 Preston JA, Horvat JC, Wade MA, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'Inhibition of allergic lung disease by respiratory Streptococcus pneumoniae infection', 5th International Symposium on Pneumococci and Pneumococcal Diseases (2006) [E3]
Co-authors Philip Hansbro, Peter Gibson, Paul Foster
2006 Preston JA, Horvat JC, Wade MA, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'The influence of allergic airways disease on the immune response to respiratory Streptococcus pneumoniae infection', 5th International Symposium on Pneumococci and Pneumococcal Diseases (2006) [E3]
Co-authors Philip Hansbro, Peter Gibson, Paul Foster
2005 Preston JA, Horvat JC, Wade MA, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'Respiratory streptococcus pneumoniae infection decreases key inflammatory responses in a mouse model of asthma', TISSUE ANTIGENS (2005)
Co-authors Philip Hansbro, Peter Gibson, Paul Foster
2005 Horvat JC, Wade MA, Preston JA, Newcombe N, Ferguson AL, Kaiko G, et al., 'Neonatal But Not Adult Chlamydial Infection Induces the Development of Allergic Airways Disease Through Novel Mechanisms Involving Inflammation of Mixed Phenotype', Tissue Antigens (2005) [E3]
Citations Web of Science - 1
Co-authors Paul Foster, Peter Gibson, Philip Hansbro
2005 Horvat JC, Preston JA, Hansbro NG, Ferguson AL, Gibson PG, Beagley KW, et al., 'Neonatal chlamydial infection inhibits the development of allergic airway inflammation in adult mice', Inflammation Research (2005) [E3]
Co-authors Nicole Hansbro, Peter Gibson, Paul Foster, Philip Hansbro
2005 Preston JA, Horvat JC, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'Timing of Streptococcus Pneumoniae (pnc) infection determines the magnitute of the effect on allergic airways inflammation (AAI) in a mouse model of asthma', Respirology (2005) [E3]
Co-authors Peter Gibson, Paul Foster, Philip Hansbro
2005 Preston JA, Horvat JC, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'Respiratory Streptococcus Pneumoniae Infection Decreases Eosinophilia and Mucus Cell Hyperplasia in a Mouse Model of Asthma', Respirology (2005) [E3]
Co-authors Paul Foster, Philip Hansbro, Peter Gibson
2005 Skelding KA, Hickey DK, Horvat JC, Hansbro PM, Bao S, Beagley KW, 'Combined transcutaneous and intranasal immunisation protects against genital tract Chlamydial infection', Proceedings of the Twelfth International Congress of Mucosal Immunology (2005) [E3]
Co-authors Philip Hansbro, Kathryn Skelding
2005 Skelding KA, Hickey DK, Horvat JC, Hansbro PM, Bao S, Beagley KW, 'Comparison of intranasal and transcutaneous immunisation for the protection against Chlamydial pneumonia', Proceedings of the Twelfth International Congress of Mucosal Immunology (2005) [E3]
Co-authors Kathryn Skelding, Philip Hansbro
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Grants and Funding

Summary

Number of grants 25
Total funding $2,831,501

Click on a grant title below to expand the full details for that specific grant.


20163 grants / $1,333,937

Galectin-3 and phagocyte function in severe asthma$701,056

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Associate Professor Jodie Simpson, Doctor Katie Baines, Doctor Jay Horvat, Dr Johan Bylund
Scheme Project Grant
Role Investigator
Funding Start 2016
Funding Finish 2018
GNo G1500194
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

How the placental protein Syncytin impairs maternal immune responses to influenza$612,881

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Peter Wark, Laureate Professor Roger Smith, Doctor Jay Horvat
Scheme Project Grant
Role Investigator
Funding Start 2016
Funding Finish 2018
GNo G1500388
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Emlyn and Jennie Thomas Postgraduate Medical Research Scholarship$20,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Miss Bridie Goggins, Doctor Simon Keely, Professor Darryl Knight, Doctor Jay Horvat
Scheme Postgraduate Research Scholarship
Role Investigator
Funding Start 2016
Funding Finish 2017
GNo G1600721
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

20153 grants / $84,698

Nose only inhalation smoke exposure system for mice$54,698

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Phil Hansbro, Laureate Professor Paul Foster, Doctor Jay Horvat, Doctor Janet Bristow, Doctor Malcolm Starkey, Doctor Rebecca Vanders
Scheme Equipment Grant
Role Investigator
Funding Start 2015
Funding Finish 2015
GNo G1501551
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

Investigation of the progression of Alzheimers Disease: Identification of potential drivers of disease$20,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Jay Horvat, Associate Professor Liz Milward, Professor Phil Hansbro, Dr Daniel Johnstone
Scheme Project Grant
Role Lead
Funding Start 2015
Funding Finish 2015
GNo G1500589
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Greaves Family Postgraduate Scholarship in Medical Research$10,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Jay Horvat, Doctor Richard Kim, Mr James Pinkerton, Professor Phil Hansbro
Scheme Postgraduate Research Scholarship
Role Lead
Funding Start 2015
Funding Finish 2015
GNo G1501396
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

20144 grants / $835,299

Interferon epsilon for Chlamydia RTIs $742,025

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Phil Hansbro, Doctor Jay Horvat, Professor Paul Hertzog
Scheme Project Grant
Role Investigator
Funding Start 2014
Funding Finish 2017
GNo G1300071
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

JuLI Stage $71,674

Funding body: NHMRC (National Health & Medical Research Council)

The role of the microbiome in the development of food allergy$20,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Simon Keely, Doctor Jay Horvat
Scheme Project Grant
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1301344
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Thoracic Society of Australia and New Zealand Annual Scientific Meeting, Adelaide AUS, 4-9 April 2014$1,600

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Doctor Jay Horvat
Scheme Travel Grant
Role Lead
Funding Start 2014
Funding Finish 2014
GNo G1400305
Type Of Funding Internal
Category INTE
UON Y

20134 grants / $392,942

Elucidating the mechanisms of infection-induced, steroid-resistant asthma$336,057

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Doctor Jay Horvat
Scheme Project Grant
Role Lead
Funding Start 2013
Funding Finish 2015
GNo G1200073
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

DP73 Digital colour and monochrome camera + cellSens software + Xcite120 fluorescence lamp illuminator$20,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Laureate Professor Paul Foster, Doctor Alan Hsu, Professor Phil Hansbro, Professor Joerg Mattes, Doctor Katie Baines, Associate Professor Jodie Simpson, Professor Rakesh Kumar, Doctor Nicole Hansbro, Doctor Steven Maltby, Doctor Ming Yang, Doctor Gerard Kaiko, Doctor Jay Horvat, Doctor Simon Keely, Doctor Andrew Jarnicki, Doctor Michael Fricker
Scheme Equipment Grant
Role Investigator
Funding Start 2013
Funding Finish 2013
GNo G1201186
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

Thoracic Society of Australia & New Zealand ASM, Darwin Convention Centre, 22 - 27 March 2013$1,885

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Doctor Jay Horvat
Scheme Travel Grant
Role Lead
Funding Start 2013
Funding Finish 2013
GNo G1300883
Type Of Funding Internal
Category INTE
UON Y

20123 grants / $66,500

SpectraMax M5e Multi-Mode Microplate Reader$50,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Laureate Professor Paul Foster, Professor Phil Hansbro, Professor Joerg Mattes, Professor Rakesh Kumar, Doctor Nicole Hansbro, Doctor Ming Yang, Doctor Jay Horvat, Doctor Simon Keely, Doctor Andrew Jarnicki, Doctor Linda Howland, Doctor Kelly Asquith
Scheme Equipment Grant
Role Investigator
Funding Start 2012
Funding Finish 2012
GNo G1100975
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

Elucidating the mechanisms of steroid-resistant asthma$15,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Jay Horvat, Professor Phil Hansbro, Laureate Professor Paul Foster
Scheme Research Grant
Role Lead
Funding Start 2012
Funding Finish 2012
GNo G1200190
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Thoracic Society of Australia and New Zealand, Canberra, 31 March - 4 April 2012$1,500

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Doctor Jay Horvat
Scheme Travel Grant
Role Lead
Funding Start 2012
Funding Finish 2012
GNo G1200427
Type Of Funding Internal
Category INTE
UON Y

20113 grants / $61,625

SCIREQ FlexiVentFX system + FlexiVentFX extension$45,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Phil Hansbro, Laureate Professor Paul Foster, Professor Joerg Mattes, Doctor Simon Keely, Doctor Jay Horvat, Doctor Nicole Hansbro, Doctor Ming Yang, Doctor Catherine Ptaschinski, Doctor Kelly Asquith, Doctor Gough Au, Conjoint Professor Peter Wark, Laureate Professor John Aitken, Conjoint Professor Keith Jones, Laureate Professor Roger Smith, Professor Judith Black, Professor Rakesh Kumar, Professor Paul Hertzog
Scheme Equipment Grant
Role Investigator
Funding Start 2011
Funding Finish 2011
GNo G1100037
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

Antioxidant therapies for suppressing infection-induced asthma in children$15,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Jay Horvat, Associate Professor Lisa Wood, Professor Phil Hansbro
Scheme Youth Research Project Grant
Role Lead
Funding Start 2011
Funding Finish 2011
GNo G1001002
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Thoracic Society of Australia & New Zealand ASM 2011, Perth Convention & Exhibition Centre, Perth WA, 2-4 April 2011$1,625

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Doctor Jay Horvat
Scheme Travel Grant
Role Lead
Funding Start 2011
Funding Finish 2011
GNo G1100399
Type Of Funding Internal
Category INTE
UON Y

20101 grants / $25,000

Improved Treatment Strategies for Infection-Induced Neutrophilic Asthma$25,000

Funding body: Asthma Foundation of New South Wales

Funding body Asthma Foundation of New South Wales
Project Team Doctor Jay Horvat
Scheme Research Grant
Role Lead
Funding Start 2010
Funding Finish 2010
GNo G0900078
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

20093 grants / $26,500

Immunisation against chlamydia-associated asthma$20,000

Funding body: Rebecca L Cooper Medical Research Foundation Ltd

Funding body Rebecca L Cooper Medical Research Foundation Ltd
Project Team Doctor Jay Horvat, Professor Phil Hansbro, Laureate Professor Paul Foster
Scheme Research Grant
Role Lead
Funding Start 2009
Funding Finish 2009
GNo G0189629
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

PULSE Education Prize$4,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Jay Horvat
Scheme PULSE Education Prize
Role Lead
Funding Start 2009
Funding Finish 2009
GNo G0189892
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

American Association of Immunologists and American Thoracic Society, Seattle USA, 8-21 May 2009$2,500

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Doctor Jay Horvat
Scheme Travel Grant
Role Lead
Funding Start 2009
Funding Finish 2009
GNo G0190127
Type Of Funding Internal
Category INTE
UON Y

20041 grants / $5,000

Modulation of asthma by chlamydial infection at different ages$5,000

Funding body: Asthma Foundation of New South Wales

Funding body Asthma Foundation of New South Wales
Project Team Doctor Jay Horvat, Professor Phil Hansbro, Conjoint Professor Kenneth Beagley
Scheme PhD Scholarships
Role Lead
Funding Start 2004
Funding Finish 2004
GNo G0183717
Type Of Funding Donation - Aust Non Government
Category 3AFD
UON Y
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Research Supervision

Number of supervisions

Completed4
Current15

Total current UON EFTSL

PhD3.6

Current Supervision

Commenced Level of Study Research Title / Program / Supervisor Type
2015 PhD Fatty Acids and Bronchodilator Responses
PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2015 PhD Neuropathological Effects of Putative Modifiers of Alzheimer's Disease Risk and Progression: Investigation in Mouse Models
PhD (Medical Genetics), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2015 PhD Contribution of Cell Death to the Pathogenesis of Chronic Obstructive Pulmonary Disease (COPD)
PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2015 PhD Investigation of Novel Immune Molecules in the Pathogenesis of Female Chlamydia Genital Tract Infections
PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2015 PhD To assess the role of IFNe in modulating innate immune responses and protecting against Chlamydia infection in human tissues
PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2015 PhD Novel Strategies to Treat Reproductive Tract Infection and Subsequent Infertility
PhD (Medical Biochemistry), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2014 PhD Hypoxia Inducible Factor (HIF)-1 mediates epithelial wound healing through integrin regulation
PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2014 PhD Investigating the inter-relationship between iron, infection and immunity in the pathogenesis of lung disease
PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2013 PhD Role of TLR/IL-13/STAT6/PI3K Response in Early-life Respiratory Infection and Infection-Induced Chronic Lung Disease
PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2013 PhD Elucidating the Mechanisms of Infection-Induced, Steroid-Resistant Asthma
PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2013 PhD Investigation of the pathogenesis and potential therapeutic interventions of influenza in Asthma and COPD
PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2011 PhD The Role of Interferon Epsilon in Protection Against Chlamydial Reproductive Tract Infections
PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2011 PhD Mechanisms of Predisposition to Secondary Bacterial Infection
PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2011 PhD Mechanisms of Lung Inflammation Associated with Inflammatory Bowel Disease
PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2010 PhD Identification of Novel Therapeutics in Chronic Obstructive Pulmonary Disease/Emphysema
PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor

Past Supervision

Year Level of Study Research Title / Program / Supervisor Type
2016 PhD Immunoregulatory Therapies for Inflammatory Diseases
PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2016 PhD Role of Fibulin-1 in the Pathogenesis of Chronic Pulmonary Diseases
PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2015 PhD Investigation of the Mechanisms of Respiratory Infection- Induced Lung Disease
PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2014 PhD Immune Mechanisms that Underpin Early-Life Chlamydia Respiratory Infection-Induced Chronic Lung Disease
PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
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News

HMRI logo

Newcastle researchers help in fight against STDs

March 1, 2013

Newcastle researchers have contributed to the discovery of a protein in the female reproductive tract that protects against sexually transmitted diseases (STDs) such as chlamydia and herpes simplex virus (HSV).

Dr Jay Horvat

Position

Senior Lecturer
Inflammation and infection-induced diseases research group
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

Focus area

Immunology and Microbiology

Contact Details

Email jay.horvat@newcastle.edu.au
Phone (02) 40 420220
Fax (02) 40 420026

Office

Room Level 2, East Wing HMRI Building
Building HMRI Building
Location Other

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