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Dr Hannah Palliser

Research Fellow

School of Biomedical Sciences and Pharmacy (Pharmacy and Experimental Pharmacology)

Career Summary

Biography

Research Expertise
- Premature labour - Intrauterine growth restriction - Fetal and neonatal neurodevelopment and wellbeing - Animal models - Myometrial activity - Progesterone and neuroprotection 

Collaborations
Premature labour, Intrauterine growth restriction, Fetal and neonatal neurodevelopment and wellbeing, Animal models, Myometrial activity, Progesterone and neuroprotection.


Qualifications

  • Doctor of Philosophy, Monash University
  • Bachelor of Science (Biomedical), Monash University
  • Bachelor of Science (Honours)(Biomedical), Monash University

Keywords

  • Fetal
  • Labour
  • Myometrial
  • Neurosciences
  • Paediatrics
  • Reproductive Medicine

Fields of Research

CodeDescriptionPercentage
111499Paediatrics and Reproductive Medicine not elsewhere classified65
111799Public Health and Health Services not elsewhere classified20
170299Cognitive Sciences not elsewhere classified15

Professional Experience

UON Appointment

DatesTitleOrganisation / Department
1/01/2015 - 31/12/2015Research FellowUniversity of Newcastle
School of Biomedical Sciences and Pharmacy
Australia

Academic appointment

DatesTitleOrganisation / Department
1/07/2007 - 1/07/2012Fellow UON
UoN Research Fellowship
University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Journal article (30 outputs)

YearCitationAltmetricsLink
2015Dyson RM, Palliser HK, Latter JL, Kelly MA, Chwatko G, Glowacki R, Wright IMR, 'Interactions of the Gasotransmitters Contribute to Microvascular Tone (Dys) regulation in the Preterm Neonate', PLOS ONE, 10 (2015)
DOI10.1371/journal.pone.0121621Author URL
2015Shaw JC, Palliser HK, Walker DW, Hirst JJ, 'Preterm birth affects GABAA receptor subunit mRNA levels during the foetal-to-neonatal transition in guinea pigs', Journal of Developmental Origins of Health and Disease, (2015)

Modulation of gamma-aminobutyric acid A (GABAA) receptor signalling by the neurosteroid allopregnanolone has a major role in late gestation neurodevelopment. The objective of this... [more]

Modulation of gamma-aminobutyric acid A (GABAA) receptor signalling by the neurosteroid allopregnanolone has a major role in late gestation neurodevelopment. The objective of this study was to characterize the mRNA levels of GABAA receptor subunits (a4, a5, a6 and d) that are key to neurosteroid binding in the brain, following preterm birth. Myelination, measured by the myelin basic protein immunostaining, was used to assess maturity of the preterm brains. Foetal guinea pig brains were obtained at 62 days¿ gestational age (GA, preterm) or at term (69 days). Neonates were delivered by caesarean section, at 62 days GA and term, and maintained until tissue collection at 24 h of age. Subunit mRNA levels were quantified by RT-PCR in the hippocampus and cerebellum of foetal and neonatal brains. Levels of the a6 and d subunits were markedly lower in the cerebellum of preterm guinea pigs compared with term animals. Importantly, there was an increase in mRNA levels of these subunits during the foetal-to-neonatal transition at term, which was not seen following preterm birth. Myelination was lower in preterm neonatal brains, consistent with marked immaturity. Salivary cortisol concentrations, measured by EIA, were also higher for the preterm neonates, suggesting greater stress. We conclude that there is an adaptive increase in the levels of mRNA of the key GABAA receptor subunits involved in neurosteroid action after term birth, which may compensate for declining allopregnanolone levels. The lower levels of these subunits in preterm neonates may heighten the adverse effect of the premature decline in neurosteroid exposure.

DOI10.1017/S2040174415000069
Co-authorsJon Hirst
2015Palliser HK, Kelleher MA, Tolcos M, Walker DW, Hirst JJ, 'Effect of postnatal progesterone therapy following preterm birth on neurosteroid concentrations and cerebellar myelination in guinea pigs.', J Dev Orig Health Dis, 6 350-361 (2015)
DOI10.1017/S2040174415001075Author URL
Co-authorsJon Hirst
2014Dyson RM, Palliser HK, Latter JL, Chwatko G, Glowacki R, Wright IMR, 'A Role for H2S in the microcirculation of newborns: The major metabolite of H2S (thiosulphate) is increased in preterm infants', PLoS ONE, 9 (2014) [C1]

Excessive vasodilatation during the perinatal period is associated with cardiorespiratory instability in preterm neonates. Little evidence of the mechanisms controlling microvascu... [more]

Excessive vasodilatation during the perinatal period is associated with cardiorespiratory instability in preterm neonates. Little evidence of the mechanisms controlling microvascular tone during circulatory transition exists. We hypothesised that hydrogen sulphide (H2S), an important regulator of microvascular reactivity and central cardiac function in adults and animal models, may contribute to the vasodilatation observed in preterm newborns. Term and preterm neonates (24-43 weeks gestational age) were studied. Peripheral microvascular blood flow was assessed by laser Doppler. Thiosulphate, a urinary metabolite of H2S, was determined by high performance liquid chromatography as a measure of 24 hr total body H2S turnover for the first 3 days of postnatal life. H2S turnover was greatest in very preterm infants and decreased with increasing gestational age (p = 0.0001). H2S turnover was stable across the first 72 hrs of life in older neonates. In very preterm neonates, H2S turnover increased significantly from day 1 to 3 (p = 0.0001); and males had higher H2S turnover than females (p = 0.04). A significant relationship between microvascular blood flow and H2S turnover was observed on day 2 of postnatal life (p = 0.0004). H2S may play a role in maintaining microvascular tone in the perinatal period. Neonates at the greatest risk of microvascular dysfunction characterised by inappropriate peripheral vasodilatation - very preterm male neonates - are also the neonates with highest levels of total body H2S turnover suggesting that overproduction of this gasotransmitter may contribute to microvascular dysfunction in preterms. Potentially, H2S is a target to selectively control microvascular tone in the circulation of newborns. © 2014 Dyson et al.

DOI10.1371/journal.pone.0105085
CitationsScopus - 1Web of Science - 1
Co-authorsJoanna Latter, Ian Wright
2014Dyson RM, Palliser HK, Lakkundi A, de Waal K, Latter JL, Clifton VL, Wright IM, 'Early microvascular changes in the preterm neonate: a comparative study of the human and guinea pig.', Physiol Rep, 2 (2014) [C1]
DOI10.14814/phy2.12145Author URL
Co-authorsIan Wright, Joanna Latter, Vicki Clifton
2014Hirst JJ, Kelleher MA, Walker DW, Palliser HK, 'Neuroactive steroids in pregnancy: Key regulatory and protective roles in the foetal brain', Journal of Steroid Biochemistry and Molecular Biology, 139 144-153 (2014)
DOI10.1016/j.jsbmb.2013.04.002
CitationsScopus - 2
Co-authorsJon Hirst
2014Hirst JJ, Kelleher MA, Walker DW, Palliser HK, 'Neuroactive steroids in pregnancy: Key regulatory and protective roles in the foetal brain', Journal of Steroid Biochemistry and Molecular Biology, 139 144-153 (2014) [C1]

Neuroactive steroid concentrations are remarkably high in the foetal brain during late gestation. These concentrations are maintained by placental progesterone synthesis and the i... [more]

Neuroactive steroid concentrations are remarkably high in the foetal brain during late gestation. These concentrations are maintained by placental progesterone synthesis and the interaction of enzymes in the placenta and foetal brain. 5a-Pregnane-3a-ol-20-one (allopregnanolone) is a key neuroactive steroid during foetal life, although other 3a-hydroxy- pregnanes may make an additional contribution to neuroactive steroid action. Allopregnanolone modulates GABAergic inhibition to maintain a suppressive action on the foetal brain during late gestation. This action suppresses foetal behaviour and maintains the appropriate balance of foetal sleep-like behaviours, which in turn are important to normal neurodevelopment. Neuroactive steroid-induced suppression of excitability has a key role in protecting the foetal brain from acute hypoxia/ischaemia insults. Hypoxia-induced brain injury is markedly increased if neuroactive steroid levels are suppressed and there is increased seizure activity. There is also a rapid increase in allopregnanolone synthesis and hence levels in response to acute stress that acts as an endogenous protective mechanism. Allopregnanolone has a trophic role in regulating development, maintaining normal levels of apoptosis and increasing myelination during late gestation in the brain. In contrast, chronic foetal stressors, including intrauterine growth restriction, do not increase neuroactive steroid levels in the brain and exposure to repeated synthetic corticosteroids reduce neuroactive steroid levels. The reduced availability of neuroactive steroids may contribute to the adverse effects of chronic stressors on the foetal and newborn brain. Preterm birth also deprives the foetus of neuroactive steroid mediated protection and may increase vulnerability to brain injury and suboptimal development. These finding suggest replacement therapies should be explored. This article is part of a Special Issue entitled 'Pregnancy and steroids © 2013 Elsevier Ltd. All rights reserved.

DOI10.1016/j.jsbmb.2013.04.002
CitationsScopus - 3Web of Science - 2
Co-authorsJon Hirst
2014Welsh TN, Hirst JJ, Palliser H, Zakar T, 'Progesterone Receptor Expression Declines in the Guinea Pig Uterus during Functional Progesterone Withdrawal and in Response to Prostaglandins', PLOS ONE, 9 (2014) [C1]
DOI10.1371/journal.pone.0105253Author URL
Co-authorsJon Hirst
2014Palliser HK, Kelleher MA, Welsh TN, Zakar T, Hirst JJ, 'Mechanisms Leading to Increased Risk of Preterm Birth in Growth-Restricted Guinea Pig Pregnancies', REPRODUCTIVE SCIENCES, 21 269-276 (2014) [C1]
DOI10.1177/1933719113497268Author URL
Co-authorsJon Hirst
2014Cumberland AL, Palliser HK, Hirst JJ, 'Increased placental neurosteroidogenic gene expression precedes poor outcome in the preterm guinea pig', Journal of Developmental Origins of Health and Disease, 5 74-78 (2014) [C1]

Placental 5a-reductase (5aR) is influenced by in utero compromises and has a role in regulating neuroactive steroid concentrations in the fetus. The objective of this study was to... [more]

Placental 5a-reductase (5aR) is influenced by in utero compromises and has a role in regulating neuroactive steroid concentrations in the fetus. The objective of this study was to determine if changes in placental 5aR were associated with neonatal outcome after birth. Guinea pigs were delivered by cesarean section at term (GA69, n=22) or preterm (GA62, n=36) and the placenta collected. Preterm neonates were maintained for 24 h unless their condition deteriorated before this time. Enzyme mRNA expression of 5aR type-1 and 5aR type-2 were determined using real-time PCR. All preterm neonates had significantly higher 5aR2 expression in their placenta compared with placentae from term neonates (P<0.0001). Expression was also markedly higher in the placentae from neonates that did not survive until 24 h, compared with surviving preterm neonates (P=0.04). These findings suggest differences of in utero neurosteroidogenic capacity between surviving and non-surviving preterm guinea pig neonates. The increased 5aR2 mRNA expression in the placenta of non-survivors suggests an induction of the neurosteroid pathway due to prior exposure to an in utero compromise, with such exposure possibly a predisposing factor that contributed to their poor ex utero outcome. © 2014 Cambridge University Press.

DOI10.1017/S2040174413000573
Co-authorsJon Hirst
2014Shaw JC, Palliser HK, Walker DW, Hirst JJ, 'Preterm birth affects GABAA receptor subunit mRNA levels during the foetal-to-neonatal transition in guinea pigs', Journal of Developmental Origins of Health and Disease, 6 250-260 (2014)

Modulation of gamma-aminobutyric acid A (GABA<inf>A</inf>) receptor signalling by the neurosteroid allopregnanolone has a major role in late gestation neurodevelopment. The object... [more]

Modulation of gamma-aminobutyric acid A (GABAA) receptor signalling by the neurosteroid allopregnanolone has a major role in late gestation neurodevelopment. The objective of this study was to characterize the mRNA levels of GABAA receptor subunits (a4, a5, a6 and d) that are key to neurosteroid binding in the brain, following preterm birth. Myelination, measured by the myelin basic protein immunostaining, was used to assess maturity of the preterm brains. Foetal guinea pig brains were obtained at 62 days' gestational age (GA, preterm) or at term (69 days). Neonates were delivered by caesarean section, at 62 days GA and term, and maintained until tissue collection at 24 h of age. Subunit mRNA levels were quantified by RT-PCR in the hippocampus and cerebellum of foetal and neonatal brains. Levels of the a6 and d subunits were markedly lower in the cerebellum of preterm guinea pigs compared with term animals. Importantly, there was an increase in mRNA levels of these subunits during the foetal-to-neonatal transition at term, which was not seen following preterm birth. Myelination was lower in preterm neonatal brains, consistent with marked immaturity. Salivary cortisol concentrations, measured by EIA, were also higher for the preterm neonates, suggesting greater stress. We conclude that there is an adaptive increase in the levels of mRNA of the key GABAA receptor subunits involved in neurosteroid action after term birth, which may compensate for declining allopregnanolone levels. The lower levels of these subunits in preterm neonates may heighten the adverse effect of the premature decline in neurosteroid exposure.

DOI10.1017/S2040174415000069
2013Bennett GA, Palliser HK, Saxby B, Walker DW, Hirst JJ, 'Effects of Prenatal Stress on Fetal Neurodevelopment and Responses to Maternal Neurosteroid Treatment in Guinea Pigs', DEVELOPMENTAL NEUROSCIENCE, 35 416-426 (2013) [C1]
DOI10.1159/000354176Author URL
CitationsScopus - 3Web of Science - 3
Co-authorsJon Hirst
2013Kelleher MA, Hirst JJ, Palliser HK, 'Changes in neuroactive steroid concentrations after preterm delivery in the guinea pig', Reproductive Sciences, 20 1365-1375 (2013) [C1]

Background: Preterm birth is a major cause of neurodevelopmental disorders. Allopregnanolone, a key metabolite of progesterone, has neuroprotective and developmental effects in th... [more]

Background: Preterm birth is a major cause of neurodevelopmental disorders. Allopregnanolone, a key metabolite of progesterone, has neuroprotective and developmental effects in the brain. The objectives of this study were to measure the neuroactive steroid concentrations following preterm delivery in a neonatal guinea pig model and assess the potential for postnatal progesterone replacement therapy to affect neuroactive steroid brain and plasma concentrations in preterm neonates. Methods: Preterm (62-63 days) and term (69 days) guinea pig pups were delivered by cesarean section and tissue was collected at 24 hours. Plasma progesterone, cortisol, allopregnanolone, and brain allopregnanolone concentrations were measured by immunoassay. Brain 5a-reductase (5aR) expression was determined by Western blot. Neurodevelopmental maturity of preterm neonates was assessed by immunohistochemistry staining for myelination, glial cells, and neurons. Results: Brain allopregnanolone concentrations were significantly reduced after birth in both preterm and term neonates. Postnatal progesterone treatment in preterm neonates increased brain and plasma allopregnanolone concentrations. Preterm neonates had reduced myelination, low birth weight, and high mortality compared to term neonates. Brain 5aR expression was also significantly reduced in neonates compared to fetal expression. Conclusions: Delivery results in a loss of neuroactive steroid concentrations resulting in a premature reduction in brain allopregnanolone in preterm neonates. Postnatal progesterone therapy reestablished neuroactive steroid levels in preterm brains, a finding that has implications for postnatal growth following preterm birth that occurs at a time of neurodevelopmental immaturity. © 2013 The Author(s).

DOI10.1177/1933719113485295
CitationsScopus - 3Web of Science - 2
Co-authorsJon Hirst
2012Palliser HK, Yates DM, Hirst JJ, 'Progesterone receptor isoform expression in response to in utero growth restriction in the fetal guinea pig brain', Neuroendocrinology, 96 60-67 (2012) [C1]
CitationsScopus - 4Web of Science - 3
Co-authorsJon Hirst
2012Dyson RM, Palliser HK, Kelleher MA, Hirst JJ, Wright IM, 'The guinea pig as an animal model for studying perinatal changes in microvascular function', Pediatric Research, 71 20-24 (2012) [C1]
DOI10.1038/pr.2011.9
CitationsScopus - 5Web of Science - 4
Co-authorsJon Hirst, Ian Wright
2012Welsh T, Paul J, Palliser H, Hirst J, Mesiano S, Zakar T, 'PGDH Expression Decreases at Term before Labor Onset in Guinea Pig Fetal Membranes', REPRODUCTIVE SCIENCES, 19 192A-192A (2012) [C3]
Author URL
CitationsWeb of Science - 1
Co-authorsJon Hirst
2012Welsh TN, Paul JW, Palliser HK, Tabatabaeehatambakhsh SH, Hirst JJ, Mesiano S, Zakar T, '15-hydroxyprostaglandin dehydrogenase expression and localization in guinea pig gestational tissues during late pregnancy and parturition', Reproductive Sciences, 19 1099-1109 (2012) [C1]
DOI10.1177/1933719112442247
CitationsScopus - 2Web of Science - 2
Co-authorsJon Hirst, Jonathan Paul
2011Kelleher MA, Palliser HK, Walker DW, Hirst JJ, 'Sex-dependent effect of a low neurosteroid environment and intrauterine growth restriction on foetal guinea pig brain development', Journal of Endocrinology, 208 301-309 (2011) [C1]
DOI10.1677/joe-10-0248
CitationsScopus - 9Web of Science - 9
Co-authorsJon Hirst
2010Palliser HK, Zakar T, Symonds IM, Hirst JJ, 'Progesterone receptor isoform expression in the guinea pig myometrium from normal and growth restricted pregnancies', Reproductive Sciences, 17 776-782 (2010) [C1]
DOI10.1177/1933719110371517
CitationsScopus - 8Web of Science - 7
Co-authorsJon Hirst, Ian Symonds
2010Dellios NL, Lappas M, Young IR, Palliser HK, Hirst JJ, Oliva K, et al., 'Increased expression of alpha-enolase in cervico-vaginal fluid during labour', European Journal of Obstetrics Gynecology and Reproductive Biology, 153 16-22 (2010) [C1]
DOI10.1016/j.ejogrb.2010.06.014
CitationsScopus - 2Web of Science - 2
Co-authorsJon Hirst
2010McKendry AA, Palliser HK, Yates DM, Walker DW, Hirst JJ, 'The effect of betamethasone treatment on neuroactive steroid synthesis in a foetal guinea pig model of growth restriction', Journal of Neuroendocrinology, 22 166-174 (2010) [C1]
DOI10.1111/j.1365-2826.2009.01949.x
CitationsScopus - 15Web of Science - 14
Co-authorsJon Hirst
2009Hirst JJ, Walker DW, Yawno T, Palliser HK, 'Stress in pregnancy: A role for neuroactive steroids in protecting the fetal and neonatal brain', Developmental Neuroscience, 31 363-377 (2009) [C1]
DOI10.1159/000232555
CitationsScopus - 18Web of Science - 15
Co-authorsJon Hirst
2009Vu TT, Hirst JJ, Stark MJ, Wright IM, Palliser HK, Hodyl NA, Clifton VL, 'Changes in human placental 5 alpha-reductase isoenzyme expression with advancing gestation: Effects of fetal sex and glucocorticoid exposure', Reproduction Fertility and Development, 21 599-607 (2009) [C1]
DOI10.1071/rd08224
CitationsScopus - 13Web of Science - 13
Co-authorsIan Wright, Vicki Clifton, Jon Hirst
2008Hirst JJ, Palliser HK, Roach DM, Yawno T, Walker DW, 'Neurosteroids in the fetus and neonate: Potential protective role in compromised pregnancies', Neurochemistry International, 52 602-610 (2008) [C1]
DOI10.1016/j.neuint.2007.07.018
CitationsScopus - 19Web of Science - 15
Co-authorsJon Hirst
2007Young R, Rice GE, Palliser HK, Ayhan M, Dellios NL, Hirst JJ, 'Identification of bactenecin-1 in cervicovaginal fluid by two-dimensional electrophoresis in an ovine model of preterm labour', Proteomics, 7 281-288 (2007) [C1]
DOI10.1002/pmic.200500705
CitationsScopus - 4Web of Science - 4
Co-authorsJon Hirst
2007Smith R, Van Helden DF, Hirst JJ, Zakar T, Read MA, Chan EC, et al., 'Pathological interactions with the timing of birth and uterine activation', Australian & New Zealand Journal of Obstetrics & Gynaecology, 47 430-437 (2007) [C1]
DOI10.1111/j.1479-828x.2007.00775.x
CitationsScopus - 8Web of Science - 8
Co-authorsRoger Smith, Jon Hirst, Dirk Vanhelden
2006Palliser HK, Dellios N, Escalona R, Ooi G, Rice GE, Hirst J, Young IR, 'Labor-Associated Regulation of Prostaglandin E and F Synthesis and Action in the Ovine Amnion and Cervix', Reproductive Sciences, 13 19-24 (2006) [C1]
DOI10.1016/j.jsgi.2005.09.009
CitationsScopus - 5Web of Science - 5
Co-authorsJon Hirst
2005Hirst JJ, Parkington HC, Young IR, Palliser HK, Peri KG, Olsen DM, 'Delay of preterm birth in sheep by THG113.31, a prostaglandin F2[a] receptor antagonist', American Journal of Obstetrics and Gynecology, 193 256-266 (2005) [C1]
DOI10.1016/j.ajog.2004.11.009
CitationsScopus - 22Web of Science - 21
Co-authorsJon Hirst
2005Palliser HK, Hirst J, Ooi GT, Rice GE, Escalona RM, Dellios NL, et al., 'Prostaglandin E and F receptor expression and myometrial sensitivity at labour onset in sheep', Biology of Reproduction, 72 937-943 (2005) [C1]
DOI10.1095/biolreprod.104.035311
CitationsScopus - 15Web of Science - 15
Co-authorsJon Hirst
2004Palliser HK, Dellios N, Escalona R, Ooi G, Rice GE, Hirst J, Young IR, 'Changes in the Expression of prostaglandin E and F synthases at induced and spontaneous labour onset in the sheep', Journal of Endocrinology, 180 469-477 (2004) [C1]
DOI10.1677/joe.0.1800469
CitationsScopus - 19Web of Science - 17
Co-authorsJon Hirst
Show 27 more journal articles

Conference (42 outputs)

YearCitationAltmetricsLink
2012Bennett GA, Palliser HK, Kelleher MA, Saxby BM, Walker DW, Hirst JJ, 'Prenatal maternal psychosomatic stress: Effects on fetal brain development following maternal neurosteroid treatment in guinea pigs', Proceedings of the 39th Annual Meeting of the Fetal and Neonatal Physiological Society, Zeist, The Netherlands (2012) [E3]
Co-authorsJon Hirst
2012Dyson RM, Palliser HK, Latter JL, Chwatko G, Glowacki R, Wright IM, 'Hydrogen sulphide in the neonatal transitional circulation', Proceedings of the 39th Annual Meeting of the Fetal and Neonatal Physiological Society, Zeist, The Netherlands (2012) [E3]
Co-authorsJoanna Latter, Ian Wright
2012Shepherd K, Palliser HK, Dyson RM, Wright IM, 'Regulation of microvascular blood fow by heme oxygenase in the preterm neonate', Proceedings of the 39th Annual Meeting of the Fetal and Neonatal Physiological Society, Zeist, The Netherlands (2012) [E3]
Co-authorsIan Wright
2012Palliser HK, Kelleher MA, Saxby B, Walker DW, Hirst JJ, Bennett GA, 'Prenatal stress and effect of maternal neurosteroid treatment on fetal brain development in guinea pigs', Journal of Paediatrics and Child Health, Sydney, Australia (2012) [E3]
Co-authorsJon Hirst
2012Palliser HK, Hirst JJ, 'Vulnerability of compromised pregnancies to preterm labour', Journal of Paediatrics and Child Health, Sydney, Australia (2012) [E3]
Co-authorsJon Hirst
2012Welsh TN, Paul JW, Palliser HK, Hirst JJ, Mesiano S, Zakar T, 'PGDH expression decreases at term before labor onset in guinea pig fetal membranes', Reproductive Sciences, San Diego, CA (2012) [E3]
Co-authorsJonathan Paul, Jon Hirst
2011Palliser HK, Welsh TN, Zakar T, Symonds IM, Hirst JJ, 'Changes to the balance of prostaglandin synthesis and metabolism with intrauterine growth restriction contributes to preterm labour in the guinea pig', Reproductive Sciences, Miami Beach, Florida (2011) [E3]
Co-authorsJon Hirst, Ian Symonds
2011Kelleher MA, Hirst JJ, Palliser HK, 'A guinea pig model for the study of neuroactive steroid replacement in the preterm neonatal brain', Reproductive Sciences, Miami Beach, Florida (2011) [E3]
Co-authorsJon Hirst
2011Dyson RM, Palliser HK, Wright IM, 'BAD EGGS AND BABIES; IS H2S A KEY PLAYER IN THE NEWBORN CIRCULATION?', PEDIATRIC RESEARCH (2011) [E3]
DOI10.1038/pr.2011.515Author URL
2011Dyson RM, Palliser HK, Wright IM, 'H2S; A novel player in the transitional microcirculation of preterm neonates?', Proceedings of The 38th Meeting of The Fetal and Neonatal Physiological Society, Palm Cove, QLD (2011) [E3]
Co-authorsIan Wright
2011Palliser HK, Welsh TN, Zakar T, Symonds IM, Hirst JJ, 'Intrauterine growth restriction leads to increased prostaglandin synthesis and reduced metabolism contributing to preterm labour in the guinea pig', Journal of Paediatrics and Child Health, Hobart, Tasmania (2011) [E3]
Co-authorsIan Symonds, Jon Hirst
2011Dyson RM, Palliser HK, Wright IM, 'Dysregulated microvascular flow in early extrauterine life in the pretern guinea pig', Journal of Paediatrics and Child Health, Hobart, Tasmania (2011) [E3]
Co-authorsIan Wright
2011Dyson RM, Palliser HK, Wright IM, 'Early microvascular blood flow changes: Evidence from human and guinea pig neonates', XIX NSW Scientific Meeting. Programme, Sydney, NSW (2011) [E3]
Co-authorsIan Wright
2010Dyson RM, Kelleher MA, Palliser HK, Hirst JJ, Wright IM, 'The guinea pig as an animal model for studying microvascular function in the preterm neonate in early extrauterine life', 9th World Congress for Microcirculation. Final Program and Abstract Book, Paris, France (2010) [E3]
Co-authorsIan Wright, Jon Hirst
2010Dyson RM, Palliser HK, Kelleher MA, Hirst JJ, Wright IM, 'Preterm birth and intrauterine growth restriction: effect of microvascular function in the neonatal guinea pig', The Endocrine Society of Australia Annual Scientific Meeting Proceedings and Abstract Book, Sydney (2010) [E3]
Co-authorsJon Hirst, Ian Wright
2010Kelleher MA, Palliser HK, Hirst JJ, 'Premature birth results in ex utero brain development in a low neuroprotective steroid environment', The Endocrine Society of Australia Annual Scientific Meeting Proceedings and Abstract Book, Sydney (2010) [E3]
Co-authorsJon Hirst
2010Kelleher MA, Palliser HK, Hirst JJ, 'Compromised neurosteroid biosynthesis in the preterm neonate', Journal of Paediatrics and Child Health: Abstracts of the 14th Annual Congress of the Perinatal Society of Australia and New Zealand 2010, Wellington, NZ (2010) [E3]
Co-authorsJon Hirst
2010Dyson RM, Kelleher MA, Palliser HK, Wright IM, 'The guinea pig as an animal model for perinatal vascular changes?', Journal of Paediatrics and Child Health: Abstracts of the 14th Annual Congress of the Perinatal Society of Australia and New Zealand 2010, Wellington, NZ (2010) [E3]
Co-authorsIan Wright
2009McKendry AA, Palliser HK, Walker DW, Hirst JJ, 'The effect of betamethasone treatment on peripheral eurosteroidogenesis in a guinea pig model of growth restriction', Reproductive Sciences, Glasgow, Scotland (2009) [E3]
Co-authorsJon Hirst
2009Gibson KJ, Wang Y, Boyce AC, Palliser HK, Hirst JJ, Lumbers ER, 'Effects of intrauterine growth restriction on the intrarenal renin angiotensin system in the neonatal guinea pig', Journal of Paediatrics and Child Health, Darwin, NT (2009) [E3]
DOI10.1111/j.1440-1754.2009.01474.x
Co-authorsJon Hirst
2009Kelleher MA, Palliser HK, Walker DW, Hirst JJ, 'Effect of intrauterine growth restriction and pharmacologic inhibition of 5alpha-reductase on enzyme expression in the fetal cerebellum', Journal of Paediatrics and Child Health, Darwin, NT (2009) [E3]
DOI10.1111/j.1440-1754.2009.01475.x
Co-authorsJon Hirst
2009McKendry AA, Palliser HK, Walker DW, Hirst JJ, 'Effect of betamethasone treatment on steroidogenic enzyme expression in growth restricted fetal guinea pigs', Journal of Paediatrics and Child Health, Darwin, NT (2009) [E3]
DOI10.1111/j.1440-1754.2009.01475.x
Co-authorsJon Hirst
2009Palliser HK, Zakar T, Hirst JJ, 'Effect of growth restriction on myometrial progesterone receptor expression near term', Journal of Paediatrics and Child Health, Darwin, NT (2009) [E3]
DOI10.1111/j.1440-1754.2009.01474.x
Co-authorsJon Hirst
2009Roach DM, Hirst JJ, Palliser HK, 'Effect of IUGR and sex on PR expression in the fetal guinea pig brain', Journal of Paediatrics and Child Health, Darwin, NT (2009) [E3]
DOI10.1111/j.1440-1754.2009.01475.x
Co-authorsJon Hirst
2008Kelleher MA, Palliser HK, Roach DM, Sullivan RK, Walker DW, Hirst JJ, 'Effect of 5 alpha-reductase inhibition on apoptotic brain cell death and the expression of neurosteroidogenic enzymes in the fetal and neonatal guinea pig', Journal of Paediatrics and Child Health, Gold Coast, QLD (2008) [E3]
DOI10.1111/j.1440-1754.200801297.x
Co-authorsJon Hirst
2008McKendry AA, Palliser HK, Roach DM, Sullivan RK, Walker DW, Hirst JJ, 'Repeated exposure to betamethasone increases brain cell death and suppresses neurosteroidogenic pathways in the growth restricted guinea pig fetus', Journal of Paediatrics and Child Health, Gold Coast, QLD (2008) [E3]
DOI10.1111/j.1440-1754.200801297.x
Co-authorsJon Hirst
2008McKendry AA, Palliser HK, Roach DM, Sullivan RK, Walker DW, Hirst JJ, 'Effect of betamethasone treatment on brain cell death and neurosteroidogenic pathways in a guinea pig model of growth restriction', Reproductive Sciences, San Diego, CA (2008) [E3]
Co-authorsJon Hirst
2008Kelleher MA, Palliser HK, Roach DM, Sullivan RK, Walker DW, Hirst JJ, 'Effect of inhibition of 5 alpha reduced steroid synthesis on apoptotic brain cell death and neurosteroidogenic enzyme expression in the fetal and neonatal guinea pig', Reproductive Sciences, San Diego, CA (2008) [E3]
Co-authorsJon Hirst
2008Sullivan RK, Palliser HK, McKendry AA, Roach DM, Walker DW, Hirst JJ, 'Effect of betemethasone treatment on apoptotic cell death and neurosteriodogenic pathways in a guinea pig model of growth restriction', 2008 Neuroscience Meeting Planner, Washington, DC (2008) [E3]
Co-authorsJon Hirst
2008Smith AT, Palliser HK, Zakar T, Dunstan RH, Hirst JJ, 'Neurosteroid profiles in fetal, maternal and neonatal guinea pigs using gas chromatography-mass spectrometry', The Twenty-Second Fetal and Neonatal Workshop of Australia and New Zealand Abstract Book, Runaway Bay, QLD (2008) [E3]
Co-authorsJon Hirst, Hugh Dunstan
2007Smith AT, Palliser HK, Hirst JJ, 'Measurement of neurosteroids in the fetal and neonatal guinea pig brain using gas chromatography-mass spectrometry', Fetal & Neonatal Workshop of Australia and New Zealand 21st Annual Meeting. Abstracts, Melbourne, VIC (2007) [E3]
Co-authorsJon Hirst
2007Palliser HK, Roach DM, Walker DW, Hirst JJ, 'Expression of 5aReductase enzymes in the fetal guinea pig brain and placenta following intrauterine growth restriction', Reproductive Sciences (Scientific Program & Abstracts: 54th Annual Meeting, SGI), Reno, Nevada (2007) [E3]
Co-authorsJon Hirst
2007Roach DM, Palliser HK, Walker DW, Hirst JJ, 'Expression of 5aReductase enzymes in uterine tissues at term and following labor', Reproductive Sciences (Scientific Program & Abstracts: 54th Annual Meeting, SGI), Reno, Nevada (2007) [E3]
Co-authorsJon Hirst
2007Palliser HK, Roach DM, Walker DW, Hirst JJ, 'Effect of intrauterine growth restriction on the expression of 5alpha reductase in the fetal guinea pig brain and placenta', Satellite Conference of DOHaD 2007 (5th World Congress of Developmental Origins of Health and Disease), Melbourne, VIC (2007) [E3]
Co-authorsJon Hirst
2005Palliser HK, Hirst JJ, Rice GE, Dellios NL, Escalona RM, Ooi GT, Young IR, 'The NF kappa B inhibitor, sulfasalazine, suppresses uterine activity by a PGHS- independent pathway.', JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION, Los Angeles, CA (2005)
Author URL
Co-authorsJon Hirst
2004Palliser HK, Dellios N, Escalona R, Rice GE, Hirst JJ, Young IR, '2004 Changes in prostaglandin receptor expression in the amnion and cervix following preterm and term labour', Endocrine Society of Australian 47th Annual Meeting, Not Known (2004) [E3]
Co-authorsJon Hirst
2004Palliser HK, Hirst JJ, Rice GE, Dellios NL, Escalona RM, Ooi GT, Young IR, 'Expression of prostaglandin E and F receptors in ovine gestational tissues at labour onset', Perinatal Society of Australia and New Zealand 7th Annual Meeting, Not Known (2004) [E3]
Co-authorsJon Hirst
2004Palliser HK, Hirst JJ, Rice GE, Dellios NL, Escalona RM, Ooi GT, Young IR, 'Increase in the expression of prostaglandin F synthase in ovine gestational tissues at labor onset.', JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION, Houston, TX (2004)
Author URL
Co-authorsJon Hirst
2004Hirst JJ, Young IR, Palliser HK, Peri KG, Zaragoza DB, Olson DM, 'Delay of preterm birth in sheep by THG113.31, a prostaglandin (PG)F-2 alpha receptor (FP) antagonist: Electromyographic activity (EMG), blood gases, and PGs.', JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION, Houston, TX (2004)
Author URL
Co-authorsJon Hirst
2004Parkington HC, Hirst JJ, Young IR, Palliser HK, Palliser DM, 'THG-113, a prostaglandin F2a (PGF2a) receptor antagonist suppresses the sensitivity to maximal contractile activity evoked by exogenous PGF2a in isolated sheep myometrium', Society for Gynecologic Investigation 51st Annual Meeting, Not Known (2004) [E3]
Co-authorsJon Hirst
2004Palliser HK, Dellios N, Escalona R, Ooi G, Rice GE, Hirst JJ, '2004 Prostaglandin F and E synthases in ovine myometrium, endometrium and placenta during at labour onset', Society for Gynecologic Investigation 51st Annual Meeting, Not Known (2004) [E3]
Co-authorsJon Hirst
2004Hirst JJ, Young IR, Palliser HK, Peri KG, Zaragoza DB, Olson DM, '2004 delay of preterm birth in sheep by THG-113, a prostaglandin F2a receptor antagonist: electromyographic activity, blood gases and PGs', Society for Gynecologic investigation 51st annual meeting, Not Known (2004) [E3]
Co-authorsJon Hirst
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Grants and Funding

Summary

Number of grants13
Total funding$1,904,777

Click on a grant title below to expand the full details for that specific grant.


20151 grants / $1,151,520

Perinatal stress leads to neurosteroid deficits and adverse behavioural outcomes$1,151,520

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Jon Hirst, Associate Professor David Walker, Doctor Hannah Palliser, Professor Deborah Hodgson
SchemeProject Grant
RoleInvestigator
Funding Start2015
Funding Finish2015
GNoG1400014
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

20142 grants / $47,512

Progesterone therapy for preterm labour - evaluation of effects on fetal neuroactive steroid profiles$27,512

Funding body: John Hunter Hospital Charitable Trust Fund

Funding bodyJohn Hunter Hospital Charitable Trust Fund
Project TeamProfessor Jon Hirst, Professor Ian Symonds, Doctor Hannah Palliser
SchemeResearch Grant
RoleInvestigator
Funding Start2014
Funding Finish2014
GNoG1400122
Type Of FundingOther Public Sector - State
Category2OPS
UONY

Stress in pregnancy and poor neurodevelopmental outcomes in children: the role of miRNA in regulating neurosteroid dysfunction$20,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Hannah Palliser, Professor Jon Hirst
SchemeProject Grant
RoleLead
Funding Start2014
Funding Finish2014
GNoG1401439
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

20121 grants / $34,454

Disruption of gestational neurosteroid concentrations by stressful events leads to adverse neurodevelopmental and behavioural outcomes in children form these pregnancies$34,454

Funding body: John Hunter Hospital Charitable Trust Fund

Funding bodyJohn Hunter Hospital Charitable Trust Fund
Project TeamProfessor Jon Hirst, Professor Ian Symonds, Doctor Hannah Palliser
SchemeResearch Grant
RoleInvestigator
Funding Start2012
Funding Finish2012
GNoG1200176
Type Of FundingOther Public Sector - State
Category2OPS
UONY

20111 grants / $2,000

Society for Gynecologic Investigation (SGI), Miami, Florida, USA, 16 - 19 March 2011$2,000

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding bodyUniversity of Newcastle - Faculty of Health and Medicine
Project TeamDoctor Hannah Palliser
SchemeTravel Grant
RoleLead
Funding Start2011
Funding Finish2011
GNoG1100147
Type Of FundingInternal
CategoryINTE
UONY

20101 grants / $23,025

Investigation of IUGR-associated preterm labour using a guinea pig model$23,025

Funding body: John Hunter Hospital Charitable Trust Fund

Funding bodyJohn Hunter Hospital Charitable Trust Fund
Project TeamDoctor Hannah Palliser, Professor Jon Hirst, Professor Ian Symonds
SchemeResearch Grant
RoleLead
Funding Start2010
Funding Finish2010
GNoG1000119
Type Of FundingOther Public Sector - State
Category2OPS
UONY

20091 grants / $13,470

i-STAT 1 Blood Gas Analyser and Softron BP-98E$13,470

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamConjoint Professor Ian Wright, Professor Jon Hirst, Professor Eugenie Lumbers, Conjoint Professor Tam Zakar, Doctor Hannah Palliser
SchemeEquipment Grant
RoleInvestigator
Funding Start2009
Funding Finish2009
GNoG0189843
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

20082 grants / $24,808

Does fetal growth restriction increase uterine activity and upregulate labour associated genes preterm?$15,208

Funding body: John Hunter Hospital Charitable Trust Fund

Funding bodyJohn Hunter Hospital Charitable Trust Fund
Project TeamProfessor Jon Hirst, Doctor Hannah Palliser, Professor Ian Symonds
SchemeResearch Grant
RoleInvestigator
Funding Start2008
Funding Finish2008
GNoG0189368
Type Of FundingOther Public Sector - State
Category2OPS
UONY

LED fluorescence illuminators and filter set (525nm + 575DF20) for LAS3000 image analysis system$9,600

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Roger Smith, Professor Ian Symonds, Conjoint Associate Professor Andrew Bisits, Conjoint Professor Tam Zakar, Doctor John Fitter, Doctor Cheng Chan, Conjoint Associate Professor Rick Nicholson, Doctor Giavanna Angeli, Doctor Kaushik Maiti, Doctor Jonathan Paul, Professor Jon Hirst, Doctor Hannah Palliser, Professor Eugenie Lumbers
SchemeEquipment Grant
RoleInvestigator
Funding Start2008
Funding Finish2008
GNoG0188543
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

20074 grants / $607,988

2007 Research Fellowship - PRCRS$565,618

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Hannah Palliser
SchemeResearch Fellowship
RoleLead
Funding Start2007
Funding Finish2007
GNoG0187107
Type Of FundingInternal
CategoryINTE
UONY

Beta Radiation Counter Instrument facility$25,670

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Roger Smith, Conjoint Associate Professor Vicki Clifton, Conjoint Professor Tam Zakar, Conjoint Associate Professor Rick Nicholson, Dr Mark Read, Doctor Cheng Chan, Doctor John Fitter, Conjoint Associate Professor Andrew Bisits, Professor Jon Hirst, Doctor Hannah Palliser, Professor Ian Symonds
SchemeEquipment Grant
RoleInvestigator
Funding Start2007
Funding Finish2007
GNoG0188194
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

2007 Research Fellowship Project Grant$15,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Hannah Palliser
SchemeFellowship Grant
RoleLead
Funding Start2007
Funding Finish2007
GNoG0188119
Type Of FundingInternal
CategoryINTE
UONY

Society of Gynecologic Investigation, 14-17 March 2007$1,700

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Hannah Palliser
SchemeTravel Grant
RoleLead
Funding Start2007
Funding Finish2007
GNoG0187373
Type Of FundingInternal
CategoryINTE
UONY
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Research Supervision

Current Supervision

CommencedResearch Title / Program / Supervisor Type
2015Perinatal Stress and its Effect on Neurosteroid Levels and Behavioural Outcomes
Pharmacy, Faculty of Health and Medicine
Co-Supervisor
2014Neurosteroidogenesis, Neurodevelopment and Behaviour Following Preterm Birth: Effect of Prenatal and Postnatal Therapies
Pharmacy, Faculty of Health and Medicine
Co-Supervisor
2013Affect of Prenatal Insults on Long-Term Behaviour and Neurodevelopment; and Potential Neurosteroid Replacement Therapy
Pharmacy, Faculty of Health and Medicine
Co-Supervisor
2012The Effects of Prenatal Stress on Perinatal Neurodevelopment and Behaviour
Pharmacy, Faculty of Health and Medicine
Co-Supervisor

Past Supervision

YearResearch Title / Program / Supervisor Type
2015Understanding Microvascular Function in Preterm Neonates
Paediatrics, Faculty of Health and Medicine
Co-Supervisor
2012Potential Neurosteroid Replacement Therapy Following Premature Birth and Fetal Growth Restriction
Pharmacy, Faculty of Health and Medicine
Co-Supervisor
2010Betamethasone: A Neuroactive Steroid Deficit and Adverse Effects in the Brain?
Pharmacy, Faculty of Health and Medicine
Co-Supervisor
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Dr Hannah Palliser

Position

Research Fellow
Mothers and Babies Research Centre
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

Focus area

Pharmacy and Experimental Pharmacology

Contact Details

Emailhannah.palliser@newcastle.edu.au
Phone(02) 4042 0371

Office

BuildingHMRI
LocationLevel 3 East

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