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Dr Giavanna Angeli

HMRI Research Officer

School of Medicine and Public Health

Career Summary


Research Expertise
During my PhD studies, completed jointly in the Mothers and Babies Research Centre and the Cell Signalling Unit, at the Children’s Medical Research I developed a strong interest in intracellular signalling mechanisms, with a particular emphasis on protein kinases and protein phosphorylation. My PhD thesis explored signalling through cAMP-dependent protein kinase (PKA) in the pituitary. During this time I developed a particular interest in the actions of corticotrophin releasing hormone. Following my PhD I gained some experience in the field of vascular biology where I developed an interest in apoptosis in particular, the role of apoptosis in tissue remodelling following vascular grafting. Since returning to the Mothers and Babies Research Centre at the University of Newcastle, I have developed an interest in the syncytialisation of cytotrophoblast cells in the placenta. Fusion of cytotrophoblast cells to form the syncytiotrophoblast layer is a fundamental process in the formation and maintenance of the placenta. The dramatic changes in expression of genes that occurs as cells alter their phenotype from cytotrophoblast to syncytiotrophoblast make the placental trophoblast an ideal model in which to explore transcriptional organisation in the nucleus, in particular, the formation and function of transcription factories. I am also the Ethics Officer for the Mothers and Babies Research Centre and have gained extensive experience in the co-ordination of grant submissions.


  • PhD, University of Newcastle
  • Bachelor of Science, University of Newcastle
  • Bachelor of Science (Honours), University of Newcastle


  • Corticotropin releasing hormone
  • FISH
  • Intracellular signalling
  • Placenta
  • Placental cell culture
  • Syncytiotrophoblast
  • Transcription

Fields of Research

Code Description Percentage
119999 Medical and Health Sciences not elsewhere classified 100

Professional Experience

UON Appointment

Title Organisation / Department
HMRI Research Officer University of Newcastle
School of Medicine and Public Health


For publications that are currently unpublished or in-press, details are shown in italics.

Journal article (4 outputs)

Year Citation Altmetrics Link
2013 Chen Y, Allars M, Pan X, Maiti K, Angeli G, Smith R, Nicholson RC, 'Effects of corticotrophin releasing hormone (CRH) on cell viability and differentiation in the human BeWo choriocarcinoma cell line: a potential syncytialisation inducer distinct from cyclic adenosine monophosphate (cAMP)', REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY, 11 (2013) [C1]
DOI 10.1186/1477-7827-11-30
Citations Scopus - 2Web of Science - 2
Co-authors Roger Smith
2011 Chen Y, Allars MJ, Maiti K, Angeli GL, Abou-Seif C, Smith R, Nicholson RC, 'Factors affecting cytotrophoblast cell viability and differentiation: Evidence of a link between syncytialisation and apoptosis', International Journal of Biochemistry & Cell Biology, 43 821-828 (2011) [C1]
DOI 10.1016/j.biocel.2011.02.007
Citations Scopus - 6Web of Science - 4
Co-authors Roger Smith
2002 Huang P, Med M, Hawthorne WJ, Ao P, Angeli GL, Medbury HJ, Fletcher JP, 'Perigraft adventitia and intima remodeling after synthetic patch implantation in sheep carotid artery: Role of apoptosis and proliferation', JOURNAL OF VASCULAR SURGERY, 36 371-378 (2002)
DOI 10.1067/mva.2002.123749
Citations Scopus - 2Web of Science - 2
2001 Huang P, Hawthorne WJ, Peng A, Angeli GL, Medbury HJ, Fletcher JP, 'Calcium channel antagonist verapamil inhibits neointimal formation and enhances apoptosis in a vascular graft model', AMERICAN JOURNAL OF SURGERY, 181 492-498 (2001)
DOI 10.1016/S0002-9610(01)00615-8
Citations Scopus - 18Web of Science - 13
Show 1 more journal article

Grants and Funding


Number of grants 2
Total funding $33,409

Click on a grant title below to expand the full details for that specific grant.

20131 grants / $23,809

Testing parallels between placental and cancer cell proliferation and fusion: the role of transcription factories$23,809

Funding body: John Hunter Hospital Charitable Trust Fund

Funding body John Hunter Hospital Charitable Trust Fund
Project Team Doctor Giavanna Angeli, Doctor Jorge Tolosa Gonzalez, Doctor Brett Locker, Doctor Jennette Sakoff
Scheme Research Grant
Role Lead
Funding Start 2013
Funding Finish 2013
GNo G1301207
Type Of Funding Other Public Sector - State
Category 2OPS

20081 grants / $9,600

LED fluorescence illuminators and filter set (525nm + 575DF20) for LAS3000 image analysis system$9,600

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Roger Smith, Professor Ian Symonds, Conjoint Associate Professor Andrew Bisits, Conjoint Professor Tam Zakar, Doctor John Fitter, Doctor Cheng Chan, Conjoint Associate Professor Rick Nicholson, Doctor Giavanna Angeli, Doctor Kaushik Maiti, Doctor Jonathan Paul, Professor Jon Hirst, Doctor Hannah Palliser, Professor Eugenie Lumbers
Scheme Equipment Grant
Role Investigator
Funding Start 2008
Funding Finish 2008
GNo G0188543
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC

Dr Giavanna Angeli


HMRI Research Officer
Mothers and Babies research Centre
School of Medicine and Public Health
Faculty of Health and Medicine

Contact Details

Phone 40420350
Fax (02) 4042 0350


Room Level 3 East
Building HMRI
Location HMRI