During my PhD studies, completed jointly in the Mothers and Babies Research Centre and the Cell Signalling Unit, at the Childrenâs Medical Research I developed a strong interest in intracellular signalling mechanisms, with a particular emphasis on protein kinases and protein phosphorylation. My PhD thesis explored signalling through cAMP-dependent protein kinase (PKA) in the pituitary. During this time I developed a particular interest in the actions of corticotrophin releasing hormone.
Following my PhD I gained some experience in the field of vascular biology where I developed an interest in apoptosis in particular, the role of apoptosis in tissue remodelling following vascular grafting.
Since returning to the Mothers and Babies Research Centre at the University of Newcastle, I have developed an interest in the syncytialisation of cytotrophoblast cells in the placenta. Fusion of cytotrophoblast cells to form the syncytiotrophoblast layer is a fundamental process in the formation and maintenance of the placenta. The dramatic changes in expression of genes that occurs as cells alter their phenotype from cytotrophoblast to syncytiotrophoblast make the placental trophoblast an ideal model in which to explore transcriptional organisation in the nucleus, in particular, the formation and function of transcription factories. I am also the Ethics Officer for the Mothers and Babies Research Centre and have gained extensive experience in the co-ordination of grant submissions.
PhD, University of Newcastle
Bachelor of Science, University of Newcastle
Bachelor of Science (Honours), University of Newcastle
Corticotropin releasing hormone
Placental cell culture
Fields of Research
Medical and Health Sciences not elsewhere classified
For publications that are currently unpublished or in-press, details are shown in italics.
Journal article (4 outputs)
Chen Y, Allars M, Pan X, Maiti K, Angeli G, Smith R, Nicholson RC, 'Effects of corticotrophin releasing hormone (CRH) on cell viability and differentiation in the human BeWo choriocarcinoma cell line: a potential syncytialisation inducer distinct from cyclic adenosine monophosphate (cAMP)', REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY, 11 (2013) [C1]
Chen Y, Allars MJ, Maiti K, Angeli GL, Abou-Seif C, Smith R, Nicholson RC, 'Factors affecting cytotrophoblast cell viability and differentiation: Evidence of a link between syncytialisation and apoptosis', International Journal of Biochemistry & Cell Biology, 43 821-828 (2011) [C1]
Huang P, Med M, Hawthorne WJ, Ao P, Angeli GL, Medbury HJ, Fletcher JP, 'Perigraft adventitia and intima remodeling after synthetic patch implantation in sheep carotid artery: Role of apoptosis and proliferation', JOURNAL OF VASCULAR SURGERY, 36 371-378 (2002)