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Staff Profile


Career Summary


  • PhD, University of Newcastle, 03/03/2000
  • Bachelor of Science, University of Newcastle, 30/04/1993
  • Bachelor of Science (Honours), University of Newcastle, 06/05/1994


Research keywords

  • Corticotropin releasing hormone
  • FISH
  • Intracellular signalling
  • Placenta
  • Placental cell culture
  • Syncytiotrophoblast
  • Transcription

Research expertise

During my PhD studies, completed jointly in the Mothers and Babies Research Centre and the Cell Signalling Unit, at the Children’s Medical Research I developed a strong interest in intracellular signalling mechanisms, with a particular emphasis on protein kinases and protein phosphorylation. My PhD thesis explored signalling through cAMP-dependent protein kinase (PKA) in the pituitary. During this time I developed a particular interest in the actions of corticotrophin releasing hormone.

Following my PhD I gained some experience in the field of vascular biology where I developed an interest in apoptosis in particular, the role of apoptosis in tissue remodelling following vascular grafting.

Since returning to the Mothers and Babies Research Centre at the University of Newcastle, I have developed an interest in the syncytialisation of cytotrophoblast cells in the placenta. Fusion of cytotrophoblast cells to form the syncytiotrophoblast layer is a fundamental process in the formation and maintenance of the placenta. The dramatic changes in expression of genes that occurs as cells alter their phenotype from cytotrophoblast to syncytiotrophoblast make the placental trophoblast an ideal model in which to explore transcriptional organisation in the nucleus, in particular, the formation and function of transcription factories. I am also the Ethics Officer for the Mothers and Babies Research Centre and have gained extensive experience in the co-ordination of grant submissions.

Fields of Research

119999Medical And Health Sciences Not Elsewhere Classified100


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Journal article (4 outputs)

2013Chen Y, Allars M, Pan X, Maiti K, Angeli G, Smith R, Nicholson RC, 'Effects of corticotrophin releasing hormone (CRH) on cell viability and differentiation in the human BeWo choriocarcinoma cell line: a potential syncytialisation inducer distinct from cyclic adenosine monophosphate (cAMP)', REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY, 11 (2013) [C1]
2011Chen Y, Allars MJ, Maiti K, Angeli GL, Abou-Seif C, Smith R, Nicholson RC, 'Factors affecting cytotrophoblast cell viability and differentiation: Evidence of a link between syncytialisation and apoptosis', International Journal of Biochemistry & Cell Biology, 43 821-828 (2011) [C1]
2002Huang P, Med M, Hawthorne WJ, Ao P, Angeli GL, Medbury HJ, Fletcher JP, 'Perigraft adventitia and intima remodeling after synthetic patch implantation in sheep carotid artery: Role of apoptosis and proliferation', JOURNAL OF VASCULAR SURGERY, 36 371-378 (2002)
2001Huang P, Hawthorne WJ, Peng A, Angeli GL, Medbury HJ, Fletcher JP, 'Calcium channel antagonist verapamil inhibits neointimal formation and enhances apoptosis in a vascular graft model', AMERICAN JOURNAL OF SURGERY, 181 492-498 (2001)
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Grants and Funding


Number of grants1
Total funding$9,600

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2008 (1 grants)

LED fluorescence illuminators and filter set (525nm + 575DF20) for LAS3000 image analysis system$9,600
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Roger Smith, Professor Ian Symonds, Conjoint Associate Professor Andrew Bisits, Conjoint Professor Tam Zakar, Doctor John Fitter, Doctor Cheng Chan, Conjoint Associate Professor Rick Nicholson, Doctor Giavanna Angeli, Doctor Kaushik Maiti, Doctor Jonathan Paul, Professor Jon Hirst, Doctor Hannah Palliser, Professor Eugenie Lumbers
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish

Research Supervision

Number of current supervisions0

No Supervisions.


Dr Giavanna Angeli

Work Phone40420350
Fax(02) 4042 0350
PositionHMRI Research Officer
Mothers and Babies research Centre
School of Medicine and Public Health
Faculty of Health and Medicine
The University of Newcastle, Australia
Level 3 East,