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Dr Geoff Isbister

Professor

School of Medicine and Public Health

Career Summary

Biography

Dr Isbister is a clinician researcher in clinical toxicology and his research has focused on understanding poisoning and envenoming in patients and undertaking studies to determine the effectiveness of antidotes and antivenoms in treatment of these conditions. He heads the Clinical Toxicology Research Group at the University. He has published over 220 original research publications and holds an NHMRC Senior Research Fellowship as well as being Chief Investigator on an NHMRC Program Grant. The benefits of the research include improving our understanding of the pathophysiology of both envenomation and poisoning. Much of his research challenges long held views about the treatment of poisoned and envenomed patients, including whether antivenom works. He has made clinicians re-look at what evidence there is for various treatments and why we use these treatments.

His first study of spider bite showed that the majority of spider bites cause minor effects, and the major effects only occurred with funnel-web spider bites and redback spider bites. The research also debunked the myth of the Whitetail Spider, showing that severe ulceration of the skin was due to a variety of causes but not spider bite. Other studies of bites and stings by venomous creatures, including scorpions, insects, marine animals and continues with snake bites in a national snake bite study formed the basis of his Doctor of Medicine titled: Data collection in clinical toxinology: debunking myths and developing diagnostic approaches to bites and stings
 

Research Expertise
Ongoing major areas of research include: 1) Clinical Toxinology: observational and interventional studies in envenomed patients; this includes the Australian Snakebite Project ASP. The study has changed the way antivenom is dosed, decreasing the dose used and demonstrating the efficacy of antivenom. This study continues now investigating other treatments for snake bite and is funded by the NHMRC. A recent randomised controlled trial of fresh frozen plasma for snake bite coagulopathy has shown the benefits and risks of such a treatment. A similar study has been completed in Sri Lanka in 2011 to 2015. The clinical toxicology research group laboratory based at the Calvary Mater Newcastle undertakes assays for venoms, toxins and antivenom in human blood, with very low limits of detection allowing their use in clinical and forensic cases. He recently published a multicentre study, the Redback Spider Antivenom Evaluation (RAVE II) Study, that found that antivenom did not improve the pain or effects of redback spider envenomation. This was a controversial finding that challenges the current use of antivenom and has been featured on Catalyst in Feb 2015. A previous study established hot water as a safe and easily applied treatment for blue bottle stings which changed the Australian Resuscitation Councils recommendations on the first aid treatment and was awarded the Medical Journal of Australia and Wyeth Australia award for best research published in the journal in 2006. He published a commissioned review on scorpion envenomation in the New England Journal of Medicine in 2014 2)Clinical toxicology including modelling and simulation: This is multicentre research into the pharmacokinetics and pharmacodynamics of drugs in overdose with patient blood samples and clinical data to develop clinical guidelines for treatment using novel drug modeling and simulation techniques. These studies of treatments for drug overdose have rationalized the treatment for particular drug overdoses streamlining the care for patients. This includes research into the effects of drugs on the electrocardiogram and the effect on the QT interval which is associated with fatal arrhythmias, developing a risk assessment tool (QT nomogram). He has recently published several reviews and a commentary on drug-induced QT prolongation. Other projects include prospective studies of overdose patients which with NHMRC Program funding has become the Australian Toxicology Monitoring (ATOM) study, including studies of paracetamol, digoxins and anticoagulants. His group and collaborators have published on the relative toxicity of psychotropic medications, one of these publications is now highly cited comparing newer antidepressants toxicity. There is ongoing research on serotonin toxicity and a study that developed new diagnostic criteria for serotonin toxicity. This work has changed our understanding and approach to the treatment of serotonin toxicity over the last 5 years. 3) Acute behavioural Disturbance: He has coordinated research on the sedation of violent and aggressive patients in the health care setting, with a focus on drug and alcohol induced delirium in the emergency department. This has resulted in a number of publications in Annals of Emergency Medicine and the British Journal of Psychiatry demonstrating the safety and benefits of droperidol, challenging the FDA black

Teaching Expertise
Clinical pharmacology, clinical toxicology and emergency medicine to undergraduates and post-graduates.






Qualifications

  • Doctor of Medicine, University of New South Wales
  • Bachelor of Science, University of New South Wales
  • Bachelor of Medicine & Surgery, University of New South Wales

Keywords

  • Clinical Toxicology
  • Clinical Toxinology
  • Emergency Medicine
  • Pharmacokinetics and pharmacodynamics
  • Toxinology

Fields of Research

CodeDescriptionPercentage
110299Cardiorespiratory Medicine and Haematology not elsewhere classified45
111799Public Health and Health Services not elsewhere classified20
111599Pharmacology and Pharmaceutical Sciences not elsewhere classified35

Professional Experience

UON Appointment

DatesTitleOrganisation / Department
30/01/2015 - 31/12/2018ProfessorUniversity of Newcastle
School of Medicine and Public Health
Australia
1/07/2003 - 18/01/2004LecturerUniversity of Newcastle
School of Medicine and Public Health
Australia
21/01/2002 - 31/12/2002LecturerUniversity of Newcastle
School of Medicine and Public Health
Australia

Academic appointment

DatesTitleOrganisation / Department
1/01/2010 - 1/12/2013Fellow - NHMRCUniversity of Newcastle
School of Medicine and Public Health
Australia
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Chapter (7 outputs)

YearCitationAltmetricsLink
2015Isbister GK, 'Spider Bite', Textbook of Adult Emergency Medicine, Elsevier Health Sciences, Edinburgh 1043-1046 (2015)
2015Isbister GK, 'Snakebite', Textbook of Adult Emergency Medicine, Elsevier Health Sciences, Edinburgh 1034-1039 (2015)
2013Isbister GK, Page CB, 'Beta blocker and calcium antagonist poisoning', Oxford Textbook of Critical Care, Oxford University Press, United Kingdom . (2013)
2012Vajjah P, Isbister GK, Duffull SB, 'Introduction to pharmacokinetics in clinical toxicology', Computational Toxicology, Springer Science+Business Media, New York 289-312 (2012) [B1]
2011Isbister GK, 'Trauma and Envenomations from Marine Fauna', Tintinalli's Emergency Medicine: A Comprehensive Study Guide, McGraw Hill, New York Ch207 (2011)
2004Isbister GK, 'Marine Envenomation and Poisoning', Medical Toxicology, Lippincott Williams & Wilkins, Philadelphia, PA 1621-1644 (2004)
2004Isbister GK, 'Other Arthropods', Medical Toxicology, Lippincott Williams & Wilkins, Philadelphia, PA 1606-1620 (2004)
Show 4 more chapters

Journal article (369 outputs)

YearCitationAltmetricsLink
2015Calver L, Drinkwater V, Gupta R, Page CB, Isbister GK, 'Droperidol V. haloperidol for sedation of aggressive behaviour in acute mental health: randomised controlled trial', BRITISH JOURNAL OF PSYCHIATRY, 206 223-228 (2015)
DOI10.1192/bjp.bp.114.150227Author URL
2015Calver L, Page CB, Downes MA, Chan B, Kinnear F, Wheatley L, et al., 'The Safety and Effectiveness of Droperidol for Sedation of Acute Behavioral Disturbance in the Emergency Department', Annals of Emergency Medicine, (2015)

Study objective: We investigate the safety and effectiveness of droperidol for sedation of acute behavioral disturbance in the emergency department (ED). Methods: This was a prosp... [more]

Study objective: We investigate the safety and effectiveness of droperidol for sedation of acute behavioral disturbance in the emergency department (ED). Methods: This was a prospective observational study in 6 EDs (August 2009 to April 2013). Adult patients requiring parenteral sedation for acute behavioral disturbance received droperidol 10 mg. If this did not sedate the patient within 15 minutes, further sedation was allowed but droperidol 10 mg was recommended as part of a sedation protocol. The primary outcome was the proportion of patients with an abnormal QT interval, defined by the at-risk line on the QT nomogram. Secondary outcomes were effectiveness determined by the time to sedation measured on the Sedation Assessment Tool, use of additional sedation, adverse events, and injury to staff or patients. Results: There were 1,009 patients with an ECG performed within 2 hours of droperidol administration, with a median dose of 10 mg (interquartile range [IQR]10 to 17.5 mg). Thirteen of the 1,009 patients had an abnormal QT (1.3%; 95% confidence interval 0.7% to 2.3%), but 7 of these had another cause attributed for prolonged QT (methadone, escitalopram, amiodarone, or preexisting). In 1,403 patients sedated with a median total dose of droperidol of 10 mg (IQR 10 to 20 mg), the median time to sedation was 20 minutes (IQR 10 to 30 minutes) and 97% were sedated within 120 minutes. Additional sedation was required for 435 patients (31.0%; 95% confidence interval 28.6% to 33.5%). Adverse events occurred in 70 patients (5%) and oversedation without complications in 109 (8%), the latter more common for patients receiving benzodiazepines as additional sedation (16/109 [15%]). There were no cases of torsades de pointes. Injuries occurred in 34 staff members and 4 patients. Conclusion: The study supports the use of high-dose droperidol as a safe sedating agent for patients with acute behavioral disturbance in the ED. There is no evidence of increased risk for QT prolongation with the doses used in this study.

DOI10.1016/j.annemergmed.2015.03.016
2015Berling I, Isbister G, 'Marine envenomations', AUSTRALIAN FAMILY PHYSICIAN, 44 28-32 (2015)
Author URL
2015Cooper JM, Duffull SB, Saiao AS, Isbister GK, 'The pharmacokinetics of sertraline in overdose and the effect of activated charcoal', BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 79 307-315 (2015)
DOI10.1111/bcp.12500Author URL
Co-authorsJoyce Cooper
2015Chaisakul J, Isbister GK, O'Leary MA, Parkington HC, Smith AI, Hodgson WC, Kuruppu S, 'Prothrombin activator-like toxin appears to mediate cardiovascular collapse following envenoming by Pseudonaja textilis.', Toxicon, 102 48-54 (2015)
DOI10.1016/j.toxicon.2015.05.001Author URL
2015Page CB, Isbister GK, Buckley NA, Fatovich DM, Brown SGA, 'In reply', Annals of Emergency Medicine, 65 124-125 (2015)
DOI10.1016/j.annemergmed.2014.08.021
2015Berling I, Isbister G, 'Marine envenomations', Australian Family Physician, 44 28-32 (2015)

Background: Marine stings are common but most are minor and do not require medical intervention. Severe and systemic marine envenoming is uncommon, but includes box jellyfish stin... [more]

Background: Marine stings are common but most are minor and do not require medical intervention. Severe and systemic marine envenoming is uncommon, but includes box jellyfish stings, Irukandji syndrome, major stingray trauma and blue-ringed octopus envenoming. Almost all marine injuries are caused by jellyfish stings, and penetrating injuries from spiny fish, stingrays or sea urchins. Objective: This article describes the presentation and management of marine envenomations and injuries that may occur in Australia. Discussion: First aid for jellyfish includes tentacle removal, application of vinegar for box jellyfish, and hot water immersion (45°C for 20 min) for bluebottle jellyfish stings. Basic life support is essential for severe marine envenomings that result in cardiac collapse or paralysis. Irukandji syndrome causes severe generalised pain, autonomic excess and minimal local pain, which may require large amounts of analgesia, and, uncommonly, myocardial depression and pulmonary oedema occur. Penetrating marine injuries can cause significant trauma depending on location of the injury. Large and unclean wounds may have delayed healing and secondary infection if not adequately irrigated, debrided and observed.

CitationsScopus - 1
2015Isbister GK, Bies R, 'Pharmacometrics: so much mathematics and why planes achieve their destinations with almost perfect results ...', BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 79 1-3 (2015)
DOI10.1111/bcp.12514Author URL
2015Berling I, Isbister GK, 'Hematologic Effects and Complications of Snake Envenoming', Transfusion Medicine Reviews, (2015)

Hematologic abnormalities are the most common effects of snake envenoming globally. Venom-induced consumption coagulopathy (VICC) is the commonest and most important. Other hemato... [more]

Hematologic abnormalities are the most common effects of snake envenoming globally. Venom-induced consumption coagulopathy (VICC) is the commonest and most important. Other hematologic abnormalities are an anticoagulant coagulopathy and thrombotic microangiopathy. Venom-induced consumption coagulopathy is a venom-induced activation of the clotting pathway by procoagulant toxins, resulting in clotting factor consumption and coagulopathy. The type of procoagulant toxin differs between snakes and can activate prothrombin, factor X, and factor V or consume fibrinogen. The most useful investigation in VICC is a prothrombin time/international normalized ratio. The d-dimer may assist in early diagnosis, but fibrinogen levels often add little in the clinical setting. Bedside investigations would be ideal, but point-of-care testing international normalized ratio and whole blood clotting tests have been shown to be unreliable in VICC. The major complication of VICC is hemorrhage, including intracranial hemorrhage which is often fatal. The role of antivenom in VICC is controversial and may only be beneficial for some types of snakes including Echis spp where the duration of abnormal clotting is reduced from more than a week to 24 to 48 hours. In contrast, antivenom does not appear to speed the recovery of VICC in Australian snake envenoming. Other treatments for VICC include factor replacement, observation and prevention of trauma, and heparin. An Australian study showed that fresh-frozen plasma speeds recovery of VICC, but early use may increase consumption. There is no evidence to support heparin.

DOI10.1016/j.tmrv.2014.09.005
2015Berling I, Isbister GK, 'Hematologic effects and complications of snake envenoming', Transfusion Medicine Reviews, 29 82-89 (2015)

Hematologic abnormalities are the most common effects of snake envenoming globally. Venom-induced consumption coagulopathy (VICC) is the commonest and most important. Other hemato... [more]

Hematologic abnormalities are the most common effects of snake envenoming globally. Venom-induced consumption coagulopathy (VICC) is the commonest and most important. Other hematologic abnormalities are an anticoagulant coagulopathy and thrombotic microangiopathy. Venom-induced consumption coagulopathy is a venom-induced activation of the clotting pathway by procoagulant toxins, resulting in clotting factor consumption and coagulopathy. The type of procoagulant toxin differs between snakes and can activate prothrombin, factor X, and factor V or consume fibrinogen. The most useful investigation in VICC is a prothrombin time/international normalized ratio. The d-dimer may assist in early diagnosis, but fibrinogen levels often add little in the clinical setting. Bedside investigations would be ideal, but point-of-care testing international normalized ratio and whole blood clotting tests have been shown to be unreliable in VICC. The major complication of VICC is hemorrhage, including intracranial hemorrhage which is often fatal. The role of antivenom in VICC is controversial and may only be beneficial for some types of snakes including Echis spp where the duration of abnormal clotting is reduced from more than a week to 24 to 48 hours. In contrast, antivenom does not appear to speed the recovery of VICC in Australian snake envenoming. Other treatments for VICC include factor replacement, observation and prevention of trauma, and heparin. An Australian study showed that fresh-frozen plasma speeds recovery of VICC, but early use may increase consumption. There is no evidence to support heparin.

DOI10.1016/j.tmrv.2014.09.005
CitationsScopus - 1
2015Isbister GK, 'How do we assess whether the QT interval is abnormal: myths, formulae and fixed opinion.', Clin Toxicol (Phila), 53 189-191 (2015)
DOI10.3109/15563650.2015.1014044Author URL
2015McNamara K, Isbister GK, 'Hyperlactataemia and clinical severity of acute metformin overdose.', Intern Med J, 45 402-408 (2015)
DOI10.1111/imj.12713Author URL
2015Berling I, Brown SGA, Miteff F, Levi C, Isbister GK, 'Australian elapid envenoming and intracranial haemorrhage', CLINICAL TOXICOLOGY, 53 237-237 (2015)
Author URL
Co-authorsChris Levi
2015Isbister GK, Maduwage K, Saiao A, Buckley NA, Jayamanne SF, Seyed S, et al., 'Population pharmacokinetics of an Indian F(ab')2 snake antivenom in patients with Russell's viper bite', CLINICAL TOXICOLOGY, 53 240-241 (2015)
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2015Chan BS, O'Leary M, Isbister G, Buckley NA, 'The use of digoxin-specific antibodies in chronic digoxin poisoning', CLINICAL TOXICOLOGY, 53 241-241 (2015)
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2015Berling I, Buckley NA, Isbister GK, 'The antipsychotic story ... an epidemic of prescription and overdose', CLINICAL TOXICOLOGY, 53 241-241 (2015)
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2015Isbister GK, Downes MA, Mcnamara K, Berling I, Whyte IM, Page CB, 'A novel infusion protocol for the administration of acetylcysteine', CLINICAL TOXICOLOGY, 53 249-250 (2015)
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2015Isbister GK, Buckley NA, Page CB, Brown SGA, 'A multicentre cohort study of snake envenoming defines clinical syndromes and influences clinical practice', CLINICAL TOXICOLOGY, 53 277-278 (2015)
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2015Downes MA, Berling IL, Stanley TH, Isbister GK, 'Spurious serum chloride measurement in severe metabolic disturbance associated with 2-butoxyethanol ingestion', CLINICAL TOXICOLOGY, 53 323-323 (2015)
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2015Michael A, Mustafa A, Medley G, Grice J, Roberts MS, Isbister GK, 'Severe but reversible toxicity with aldicarb ingestion', CLINICAL TOXICOLOGY, 53 334-334 (2015)
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2015Silva A, Siribaddana S, Sedgwick EM, Maduwage K, Buckley N, Isbister GK, 'Indian Krait (Bungarus caeruleus) envenoming: A clinical and neurophysiological investigation of neuromuscular dysfunction', CLINICAL TOXICOLOGY, 53 352-353 (2015)
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2015Berling I, Isbister GK, 'The myth of the half RR rule and QT prolongation', CLINICAL TOXICOLOGY, 53 354-354 (2015)
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2015Downes MA, Berling IL, Isbister GK, 'Acute behavioural disturbance associated with phenibut purchased via an Internet supplier', CLINICAL TOXICOLOGY, 53 373-373 (2015)
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2015Page CB, Mostafa A, Saiao A, Medley G, Grice J, Roberts M, Isbister G, 'Cardiovascular toxicity with levetiracetam overdose', CLINICAL TOXICOLOGY, 53 379-379 (2015)
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2015Chiew AL, Isbister GK, Buckley NA, '"Massive" paracetamol overdose', CLINICAL TOXICOLOGY, 53 380-380 (2015)
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2015Ryan N, Isbister GK, 'Tramadol overdose is associated with an increased risk of seizure but not serotonin toxicity', CLINICAL TOXICOLOGY, 53 380-381 (2015)
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2015Berling I, Brown SGA, Miteff F, Levi C, Isbister GK, 'Intracranial haemorrhages associated with venom induced consumption coagulopathy in Australian snakebites (ASP-21)', Toxicon, 102 8-13 (2015)

Intracranial haemorrhage (ICH) is a rare life-threatening consequence of venom induced consumption coagulopathy in snake-bite. It is unclear why certain patients haemorrhage. We a... [more]

Intracranial haemorrhage (ICH) is a rare life-threatening consequence of venom induced consumption coagulopathy in snake-bite. It is unclear why certain patients haemorrhage. We aimed to investigate ICH in snake envenoming. Cases of venom-induced consumption coagulopathy from July 2005-June 2014 were identified from the Australian Snakebite Project, a prospective multicentre cohort of snake-bites. Cases with venom-induced consumption coagulopathy were extracted with data on the snake-bite, clinical effects, laboratory investigations, treatment and outcomes. 552 cases had venom-induced consumption coagulopathy; median age, 40 y (2-87 y), 417 (76%) males, 253 (46%) from brown snakes and 17 died (3%). There were 6/552 (1%) cases of ICH; median age, 71 y (59-80 y), three males and five from brown snakes. All received antivenom and five died. All six had a history of hypertension. Time to onset of clinical effects consistent with ICH was 8-12 h in four cases, and within 3 h in two. Difficult to manage hypertension and vomiting were common. One patient had a normal cerebral CT on presentation and after the onset of focal neurological effects a repeat CT showed an ICH. ICH is rare in snake-bite with only 1% of patients with coagulopathy developing one. Older age and hypertension were associated with ICH.

DOI10.1016/j.toxicon.2015.05.012
2015Jones EM, Chesher D, Isbister G, Gillett MJ, 'ANNALS EXPRESS: Pneumatic tube transport of blood stained cerebrospinal fluid specimens has no clinically significant effect on rates of haemolysis compared to manual transport.', Ann Clin Biochem, (2015)
DOI10.1177/0004563215593562Author URL
2015Michael AP, Mostafa A, Cooper JM, Grice J, Roberts MS, Isbister GK, 'The pharmacokinetics and pharmacodynamics of severe aldicarb toxicity after overdose.', Clin Toxicol (Phila), 1-3 (2015)
DOI10.3109/15563650.2015.1054504Author URL
2015Maduwage K, Buckley NA, de Silva HJ, Lalloo DG, Isbister GK, 'Snake antivenom for snake venom induced consumption coagulopathy.', Cochrane Database Syst Rev, 6 CD011428 (2015)
DOI10.1002/14651858.CD011428.pub2Author URL
2015Berling I, Buckley NA, Mostafa A, Downes MA, Grice J, Medley G, et al., '2-Methyl-4-chlorophenoxyacetic acid and bromoxynil herbicide death.', Clin Toxicol (Phila), 53 486-488 (2015)
DOI10.3109/15563650.2015.1030025Author URL
2015Ryan NM, Isbister GK, 'Tramadol overdose causes seizures and respiratory depression but serotonin toxicity appears unlikely.', Clin Toxicol (Phila), 53 545-550 (2015)
DOI10.3109/15563650.2015.1036279Author URL
Co-authorsNicole Ryan
2015Skinner K, Saiao A, Mostafa A, Soderstrom J, Medley G, Roberts MS, Isbister GK, 'Isoniazid poisoning: Pharmacokinetics and effect of hemodialysis in a massive ingestion.', Hemodial Int, (2015)
DOI10.1111/hdi.12293Author URL
2015Buckley NA, Whyte IM, Dawson AH, Isbister GK, 'A prospective cohort study of trends in self-poisoning, Newcastle, Australia, 1987-2012: plus ça change, plus c'est la même chose.', Med J Aust, 202 438-442 (2015)
Author URL
2015Downes MA, Berling IL, Mostafa A, Grice J, Roberts MS, Isbister GK, 'Acute behavioural disturbance associated with phenibut purchased via an internet supplier.', Clin Toxicol (Phila), 1-3 (2015)
DOI10.3109/15563650.2015.1059945Author URL
2014Chiew AL, Isbister GK, 'A coagulopathic dilemma: snakes or genes.', Lancet, 383 2184 (2014) [C3]
DOI10.1016/S0140-6736(14)60690-5Author URL
2014Isbister GK, Bawaskar HS, 'Scorpion envenomation.', N Engl J Med, 371 457-463 (2014) [C1]
DOI10.1056/NEJMra1401108Author URL
CitationsScopus - 1Web of Science - 8
2014van Helden DF, Thomas PA, Dosen PJ, Imtiaz MS, Laver DR, Isbister GK, 'Pharmacological approaches that slow lymphatic flow as a snakebite first aid.', PLoS Negl Trop Dis, 8 e2722 (2014) [C1]
DOI10.1371/journal.pntd.0002722Author URL
Co-authorsDerek Laver, Dirk Vanhelden
2014Maduwage K, O'Leary MA, Scorgie FE, Shahmy S, Mohamed F, Abeysinghe C, et al., 'Detection of venom after antivenom is not associated with persistent coagulopathy in a prospective cohort of Russell's viper (Daboia russelii) envenomings.', PLoS Negl Trop Dis, 8 e3304 (2014) [C1]
DOI10.1371/journal.pntd.0003304Author URL
Co-authorsLisa Lincz
2014Lincz LF, Scorgie FE, Johnston CI, O'Leary M, Prasad R, Seldon M, et al., 'Comparative sensitivity of commercially available aPTT reagents to mulga snake (Pseudechis australis) venom.', Pathology, 46 444-449 (2014) [C1]
DOI10.1097/PAT.0000000000000120Author URL
CitationsScopus - 1Web of Science - 1
Co-authorsLisa Lincz
2014Maduwage K, O'Leary MA, Isbister GK, 'Diagnosis of snake envenomation using a simple phospholipase A2 assay.', Sci Rep, 4 4827 (2014) [C1]
DOI10.1038/srep04827Author URL
2014Isbister GK, Maduwage K, Page CB, 'Antivenom cross neutralisation in a suspected Asian pit viper envenoming causing severe coagulopathy.', Toxicon, 90 286-290 (2014) [C1]
DOI10.1016/j.toxicon.2014.08.071Author URL
CitationsScopus - 1Web of Science - 1
2014Chaisakul J, Isbister GK, Tare M, Parkington HC, Hodgson WC, 'Hypotensive and vascular relaxant effects of phospholipase A toxins from Papuan taipan (Oxyuranus scutellatus) venom', European Journal of Pharmacology, 723 227-233 (2014) [C1]
DOI10.1016/j.ejphar.2013.11.028
CitationsScopus - 3Web of Science - 1
2014Brinkman DL, Konstantakopoulos N, McInerney BV, Mulvenna J, Seymour JE, Isbister GK, Hodgson WC, 'Chironex fleckeri ( Box Jellyfish) Venom Proteins EXPANSION OF A CNIDARIAN TOXIN FAMILY THAT ELICITS VARIABLE CYTOLYTIC AND CARDIOVASCULAR EFFECTS*', JOURNAL OF BIOLOGICAL CHEMISTRY, 289 4798-4812 (2014) [C1]
DOI10.1074/jbc.M113.534149Author URL
CitationsScopus - 4Web of Science - 2
2014Isbister GK, Bawaskar HS, Brown SGA, 'Scorpion Envenomation REPLY', NEW ENGLAND JOURNAL OF MEDICINE, 371 1559-1560 (2014)
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2014Isbister GK, Bawaskar HS, Brown SGA, 'Scorpion Envenomation REPLY', NEW ENGLAND JOURNAL OF MEDICINE, 371 1559-1560 (2014) [C3]
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CitationsScopus - 8
2014O'Leary MA, Isbister GK, 'Detection of venom-antivenom (VAV) immunocomplexes in vitro as a measure of antivenom efficacy', TOXICON, 77 125-132 (2014) [C1]
DOI10.1016/j.toxicon.2013.11.001Author URL
CitationsScopus - 4Web of Science - 4
2014O'Leary MA, Maduwage K, Isbister GK, 'Detection of venom after antivenom administration is largely due to bound venom', Toxicon, 93 112-118 (2014)

Detection of recurrent venom post-antivenom in snake envenoming is commonly reported and thought to be due to insufficient antivenom. However, relatively few reports of recurrence... [more]

Detection of recurrent venom post-antivenom in snake envenoming is commonly reported and thought to be due to insufficient antivenom. However, relatively few reports of recurrence have venom measurement, and in most cases patients clinically improve, despite venom detected post-antivenom. We hypothesized that persistent or recurrent venom detection post-antivenom is due to detecting bound venom. Multiple (>4) serum samples were available from 255 Russell's viper (Daboia russelii) envenomed patients. Enzyme-linked immunosorbent assay was used to measure venom, antivenom and venom-antivenom (VAV) complexes. In 79/255 (31%) there was persistent/recurrent venom detected despite antivenom being present. In these post-antivenom samples, VAV was also detected at the same time as venom was detected. Anti-horse (aH) antiserum was bound to UltraLink (UL) resin and added to in vitro venom-antivenom mixtures, and 15 pre- and post-antivenom samples from patients. There was significantly less free venom detected in in vitro venom-antivenom mixtures to which ULaH had been added compared to those without ULaH added. In 9 post-antivenom patient samples the addition of ULaH reduced venom detected by a median of 80% (69%-88%) compared to only 20% in four pre-antivenom samples. This suggests that the detection of persistent/recurrent venom post-antivenom is due to bound and not free venom.

DOI10.1016/j.toxicon.2014.11.221
2014Isbister GK, Page CB, Buckley NA, Fatovich DM, Pascu O, MacDonald SPJ, et al., 'Randomized controlled trial of intravenous antivenom versus placebo for latrodectism: The second redback antivenom evaluation (RAVE-II) study', Annals of Emergency Medicine, 64 620-628 (2014)
DOI10.1016/j.annemergmed.2014.06.006
CitationsScopus - 2
2014Isbister GK, Page CB, Buckley NA, Fatovich DM, Pascu O, MacDonald SPJ, et al., 'Randomized controlled trial of intravenous antivenom versus placebo for latrodectism: The second redback antivenom evaluation (RAVE-II) study', Annals of Emergency Medicine, 64 620-628 (2014) [C1]
DOI10.1016/j.annemergmed.2014.06.006
CitationsScopus - 3Web of Science - 3
2014Berling I, Isbister GK, 'Prolonged QT Risk Assessment in Antipsychotic Overdose Usingthe QT Nomogram', Annals of Emergency Medicine, (2014)

Study objective: Antipsychotic drugs are frequently reported to cause QT prolongation and torsade de pointes. We aim to investigate the potential risk of torsade de pointes in ant... [more]

Study objective: Antipsychotic drugs are frequently reported to cause QT prolongation and torsade de pointes. We aim to investigate the potential risk of torsade de pointes in antipsychotic overdose by assessing the QT interval with the QT nomogram. Methods: All presentations to a toxicology service between January 1987 and May 2013 were reviewed. Admissions with single ingestions of an antipsychotic greater than maximum daily dose were extracted. Demographics, dose, ECG, and outcomes (arrhythmias and death) were obtained. QT intervals in multiple leads were manually measured and the median taken. QT-heart rate (QT-HR) pairs were plotted on the QT nomogram and defined as prolonged if above the abnormal line. The QTcF (Fridericia's HR correction) was calculated and compared with dose. Results: From 2,356 antipsychotic overdoses, 494 were included. There were no abnormal QT-HR pairs in 4 aripiprazole, 31 pericyazine, 14 trifluoperazine, and 7 haloperidol overdoses. Abnormal QT intervals occurred in 9 of 16 amisulpride overdoses (56%; 95% confidence interval [CI] 31% to 79%), 16 of 57 thioridazine overdoses (28%; 95% CI 17% to 42%), and 5 of 29 chlorpromazine overdoses (17%; 95% CI 7% to 36%). Abnormal QT intervals occurred in 5 of 41 risperidone overdoses (12%; 95% CI 5% to 27%), 10 of 202 quetiapine overdoses (5%; 95% CI 3% to 9%), and 2 of 76 olanzapine overdoses (3%; 95% CI 0.5% to 10%), but there was no correlation between dose and QTcF, and most abnormal QT intervals were at fast HR. An additional 186 single antipsychotic ingestions with noncardiotoxic coingestants had similar proportions of abnormal QT. There was 1 case of torsade de pointes in a thioridazine overdose. Conclusion: There appeared to be significant risk of QT prolongation with amisulpride and thioridazine overdoses. Although there were abnormal QT intervals for quetiapine, olanzapine, and risperidone overdoses, they were associated with tachycardia and not dose dependent, and so were unlikely to be associated with increased torsade de pointes risk.

DOI10.1016/j.annemergmed.2014.12.005
2014Cooper JM, Newby DA, Whyte IM, Carter G, Jones AL, Isbister GK, 'Serotonin toxicity from antidepressant overdose and its association with the T102C polymorphism of the 5-HT receptor', Pharmacogenomics J, (2014) [C1]
DOI10.1038/tpj.2013.47
CitationsScopus - 1
Co-authorsDavid Newby, Gregory Carter, Joyce Cooper
2014Berling I, Isbister GK, 'Mirtazapine overdose is unlikely to cause major toxicity', CLINICAL TOXICOLOGY, 52 20-24 (2014) [C1]
DOI10.3109/15563650.2013.859264Author URL
CitationsScopus - 3Web of Science - 3
2014Ryan NM, Brown SSGA, Isbister GK, 'Serum sickness after the administration of Australian snake antivenoms', CLINICAL TOXICOLOGY, 52 356-356 (2014)
Author URL
2014Berling I, Isbister GK, 'Antipsychotic overdose QT nomogram risk assessment', CLINICAL TOXICOLOGY, 52 436-436 (2014) [E3]
Author URL
2014Hart AJ, Hodgson WC, O'Leary M, Isbister GK, 'Pharmacokinetics and pharmacodynamics of the myotoxic venom of Pseudechis australis (mulga snake) in the anesthetised rat', CLINICAL TOXICOLOGY, 52 604-610 (2014) [C1]
DOI10.3109/15563650.2014.914526Author URL
2014Buckley NA, Dawson AH, Isbister GK, 'Serotonin syndrome', Praxis, 103 1031-1041 (2014)
2014Buckley NA, Dawson AH, Isbister GK, 'Serotonin syndrome', Praxis, 103 1031-1041 (2014) [C3]
2014Brown SGA, Isbister GK, 'Clinical research is a priority for emergency medicine but how do we make it happen, and do it well?', EMERGENCY MEDICINE AUSTRALASIA, 26 14-18 (2014) [C1]
DOI10.1111/1742-6723.12179Author URL
2014Buckley NA, Dawson AH, Isbister GK, 'PRACTICE POINTER Serotonin syndrome', BMJ-BRITISH MEDICAL JOURNAL, 348 (2014) [C3]
DOI10.1136/bmj.g1626Author URL
CitationsScopus - 13Web of Science - 7
2014Maduwage K, Isbister GK, 'Current Treatment for Venom-Induced Consumption Coagulopathy Resulting from Snakebite', PLoS Neglected Tropical Diseases, 8 (2014) [C1]

Venomous snakebite is considered the single most important cause of human injury from venomous animals worldwide. Coagulopathy is one of the commonest important systemic clinical ... [more]

Venomous snakebite is considered the single most important cause of human injury from venomous animals worldwide. Coagulopathy is one of the commonest important systemic clinical syndromes and can be complicated by serious and life-threatening haemorrhage. Venom-induced consumption coagulopathy (VICC) is the commonest coagulopathy resulting from snakebite and occurs in envenoming by Viperid snakes, certain elapids, including Australian elapids, and a few Colubrid (rear fang) snakes. Procoagulant toxins activate the clotting pathway, causing a broad range of factor deficiencies depending on the particular procoagulant toxin in the snake venom. Diagnosis and monitoring of coagulopathy is problematic, particularly in resource-poor countries where further research is required to develop more reliable, cheap clotting tests. MEDLINE and EMBASE up to September 2013 were searched to identify clinical studies of snake envenoming with VICC. The UniPort database was searched for coagulant snake toxins. Despite preclinical studies demonstrating antivenom binding toxins (efficacy), there was less evidence to support clinical effectiveness of antivenom for VICC. There were no placebo-controlled trials of antivenom for VICC. There were 25 randomised comparative trials of antivenom for VICC, which compared two different antivenoms (ten studies), three different antivenoms (four), two or three different doses or repeat doses of antivenom (five), heparin treatment and antivenom (five), and intravenous immunoglobulin treatment and antivenom (one). There were 13 studies that compared two groups in which there was no randomisation, including studies with historical controls. There have been numerous observational studies of antivenom in VICC but with no comparison group. Most of the controlled trials were small, did not use the same method for assessing coagulopathy, varied the dose of antivenom, and did not provide complete details of the study design (primary outcomes, randomisation, and allocation concealment). Non-randomised trials including comparison groups without antivenom showed that antivenom was effective for some snakes (e.g., Echis), but not others (e.g., Australasian elapids). Antivenom is the major treatment for VICC, but there is currently little high-quality evidence to support effectiveness. Antivenom is not risk free, and adverse reactions can be quite common and potentially severe. Studies of heparin did not demonstrate it improved outcomes in VICC. Fresh frozen plasma appeared to speed the recovery of coagulopathy and should be considered in bleeding patients.

DOI10.1371/journal.pntd.0003220
CitationsScopus - 2
2014Calver L, Isbister GK, 'High dose droperidol and QT prolongation: analysis of continuous 12-lead recordings.', Br J Clin Pharmacol, 77 880-886 (2014) [C1]
DOI10.1111/bcp.12272Author URL
CitationsScopus - 1
2014Gulati A, Isbister GK, Duffull SB, 'Scale reduction of a systems coagulation model with an application to modeling pharmacokinetic-pharmacodynamic data.', CPT Pharmacometrics Syst Pharmacol, 3 e90 (2014) [C1]
DOI10.1038/psp.2013.67Author URL
2014Downes MA, Calver LA, Isbister GK, 'Intralipid therapy does not improve level of consciousness in overdoses with sedating drugs: a case series.', Emerg Med Australas, 26 286-290 (2014) [C1]
DOI10.1111/1742-6723.12237Author URL
2013Isbister GK, Buckley NA, Brown SGA, 'Tiger snake (Notechis spp) envenoming: Australian Snakebite Project (ASP-13) REPLY', MEDICAL JOURNAL OF AUSTRALIA, 198 194-195 (2013) [C3]
DOI10.5694/mja12.11690Author URL
2013Allen GE, Wilson SK, Isbister GK, 'Paroplocephalus envenoming: a previously unrecognised highly venomous snake in Australia', MEDICAL JOURNAL OF AUSTRALIA, 199 792-793 (2013) [C3]
DOI10.5694/mja13.10985Author URL
2013Isbister GK, Brown SGA, Page CB, McCoubrie DL, Greene SL, Buckley NA, 'Snakebite in Australia: A practical approach to diagnosis and treatment', Medical Journal of Australia, 199 763-768 (2013) [C1]

Snakebite is a potential medical emergency and must receive high-priority assessment and treatment, even in patients who initially appear well. Patients should be treated in hospi... [more]

Snakebite is a potential medical emergency and must receive high-priority assessment and treatment, even in patients who initially appear well. Patients should be treated in hospitals with onsite laboratory facilities, appropriate antivenom stocks and a clinician capable of treating complications such as anaphylaxis. All patients with suspected snakebite should be admitted to a suitable clinical unit, such as an emergency short-stay unit, for at least 12 hours after the bite. Serial blood testing (activated partial thromboplastin time, international normalised ratio and creatine kinase level) and neurological examinations should be done for all patients. Most snakebites will not result in significant envenoming and do not require antivenom. Antivenom should be administered as soon as there is evidence of envenoming. Evidence of systemic envenoming includes venom-induced consumption coagulopathy, sudden collapse, myotoxicity, neurotoxicity, thrombotic microangiopathy and renal impairment. Venomous snake groups each cause a characteristic clinical syndrome, which can be used in combination with local geographical distribution information to determine the probable snake involved and appropriate antivenom to use. The Snake Venom Detection Kit may assist in regions where the range of possible snakes is too broad to allow the use of monovalent antivenoms. When the snake identification remains unclear, two monovalent antivenoms (eg, brown snake and tiger snake antivenom) that cover possible snakes, or a polyvalent antivenom, can be used. One vial of the relevant antivenom is sufficient to bind all circulating venom. However, recovery may be delayed as many clinical and laboratory effects of venom are not immediately reversible. For expert advice on envenoming, contact the National Poisons Information Centre on 13 11 26.

DOI10.5694/mja12.11172
CitationsScopus - 7Web of Science - 6
2013Maduwage K, Isbister GK, Silva A, Bowatta S, Mendis S, Gawarammana I, 'Epidemiology and clinical effects of hump-nosed pit viper (Genus: Hypnale) envenoming in Sri Lanka', TOXICON, 61 11-15 (2013) [C1]
DOI10.1016/j.toxicon.2012.10.013Author URL
CitationsScopus - 9Web of Science - 9
2013Gulati A, Isbister GK, Duffull SB, 'Effect of Australian elapid venoms on blood coagulation: Australian Snakebite Project (ASP-17)', TOXICON, 61 94-104 (2013) [C1]
DOI10.1016/j.toxicon.2012.11.001Author URL
CitationsScopus - 2Web of Science - 2
2013Hart AJ, Isbister GK, Hodgson WC, 'In vitro neurotoxic effects of Pseudechis spp. venoms: A comparison of avian and murine skeletal muscle preparations', TOXICON, 63 112-115 (2013) [C1]
DOI10.1016/j.toxicon.2012.12.002Author URL
CitationsScopus - 2Web of Science - 2
2013Barber CM, Isbister GK, Hodgson WC, 'Alpha neurotoxins', Toxicon, 66 47-58 (2013) [C1]
DOI10.1016/j.toxicon.2013.01.019Author URL
CitationsScopus - 11Web of Science - 8
2013O'Rourke KM, Correlje E, Martin CL, Robertson JD, Isbister GK, 'Point-of-care derived INR does not reliably detect significant coagulopathy following Australian snakebite', Thrombosis Research, 132 610-613 (2013) [C1]
DOI10.1016/j.thromres.2013.09.004Author URL
CitationsScopus - 1Web of Science - 1
2013Brown SGA, Stone SF, Fatovich DM, Burrows SA, Holdgate A, Celenza A, et al., 'Anaphylaxis: Clinical patterns, mediator release, and severity', JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 132 1141-1149 (2013) [C1]
DOI10.1016/j.jaci.2013.06.015Author URL
CitationsScopus - 23Web of Science - 18
2013Brown SGA, Stone SF, Fatovich DM, Isbister GK, 'Reply', Journal of Allergy and Clinical Immunology, 132 1457-1457 (2013) [C3]
DOI10.1016/j.jaci.2013.09.013)
2013Isbister GK, Page CB, 'Drug induced QT prolongation: the measurement and assessment of the QT interval in clinical practice', BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 76 48-57 (2013) [C1]
DOI10.1111/bcp.12040Author URL
CitationsScopus - 13Web of Science - 10
2013Chaisakul J, Isbister GK, Kuruppu S, Konstantakopoulos N, Hodgson WC, 'An examination of cardiovascular collapse induced by eastern brown snake (Pseudonaja textilis) venom', Toxicology Letters, 221 205-211 (2013) [C1]
DOI10.1016/j.toxlet.2013.06.235Author URL
CitationsScopus - 1
2013Hart AJ, Isbister GK, O'Donnell P, Williamson NA, Hodgson WC, 'Species differences in the neuromuscular activity of post-synaptic neurotoxins from two Australian black snakes (Pseudechis porphyriacus and Pseudechis colletti)', Toxicology Letters, 219 262-268 (2013) [C1]
DOI10.1016/j.toxlet.2013.03.026Author URL
CitationsScopus - 2Web of Science - 2
2013Calver L, Isbister GK, 'Parenteral sedation of elderly patients with acute behavioral disturbance in the ED', AMERICAN JOURNAL OF EMERGENCY MEDICINE, 31 970-973 (2013) [C1]
DOI10.1016/j.ajem.2013.03.026Author URL
CitationsScopus - 1
2013O'Leary MA, Maduwage K, Isbister GK, 'Use of immunoturbidimetry to detect venom-antivenom binding using snake venoms', JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, 67 177-181 (2013) [C1]
DOI10.1016/j.vascn.2013.02.004Author URL
CitationsScopus - 1Web of Science - 1
2013Berling I, Whyte IM, Isbister GK, 'Oxycodone overdose causes naloxone responsive coma and QT prolongation', QJM-AN INTERNATIONAL JOURNAL OF MEDICINE, 106 35-41 (2013) [C1]
DOI10.1093/qjmed/hcs176Author URL
CitationsScopus - 6Web of Science - 4
2013Isbister GK, Maduwage K, Shahmy S, Mohamed F, Abeysinghe C, Karunathilake H, et al., 'Diagnostic 20-min whole blood clotting test in Russell's viper envenoming delays antivenom administration', QJM-AN INTERNATIONAL JOURNAL OF MEDICINE, 106 925-932 (2013) [C1]
DOI10.1093/qjmed/hct102Author URL
CitationsScopus - 12Web of Science - 8
2013Li L, McGee RG, Isbister G, Webster AC, 'Interventions for the symptoms and signs resulting from jellyfish stings', COCHRANE DATABASE OF SYSTEMATIC REVIEWS, (2013) [C1]
DOI10.1002/14651858.CD009688.pub2Author URL
2013Calver L, Drinkwater V, Isbister GK, 'A prospective study of high dose sedation for rapid tranquilisation of acute behavioural disturbance in an acute mental health unit', BMC PSYCHIATRY, 13 (2013) [C1]
DOI10.1186/1471-244X-13-225Author URL
CitationsScopus - 1Web of Science - 1
2013Isbister GK, Buckley NA, Page CB, Scorgie FE, Lincz LF, Seldon M, Brown SGA, 'A randomized controlled trial of fresh frozen plasma for treating venom-induced consumption coagulopathy in cases of Australian snakebite (ASP-18)', Journal of Thrombosis and Haemostasis, 11 1310-1318 (2013) [C1]
DOI10.1111/jth.12218Author URL
CitationsScopus - 9Web of Science - 7
Co-authorsLisa Lincz
2013Johnston CI, Brown SGA, O'Leary MA, Currie BJ, Greenberg R, Taylor M, et al., 'Mulga snake (Pseudechis australis) envenoming: a spectrum of myotoxicity, anticoagulant coagulopathy, haemolysis and the role of early antivenom therapy - Australian Snakebite Project (ASP-19)', CLINICAL TOXICOLOGY, 51 417-424 (2013) [C1]
DOI10.3109/15563650.2013.787535Author URL
CitationsScopus - 11Web of Science - 9
2013Maduwage K, Scorgie FE, Silva A, Shahmy S, Mohamed F, Abeysinghe C, et al., 'Hump-nosed pit viper (Hypnale hypnale) envenoming causes mild coagulopathy with incomplete clotting factor consumption', CLINICAL TOXICOLOGY, 51 527-531 (2013) [C1]
DOI10.3109/15563650.2013.811589Author URL
CitationsScopus - 5Web of Science - 5
Co-authorsLisa Lincz
2013Isbister GK, Duffull SB, 'When is research clinical advice? Interpreting an exploratory study of paracetamol overdose', Clinical Toxicology, 51 1242-1242 (2013) [C3]
DOI10.3109/15563650.2013.857780
2013Isbister GK, Duffull SB, 'Understanding probability and exposure in paracetamol overdose risk assessment', Clinical Toxicology, 51 1240-1240 (2013) [C3]
DOI10.3109/15563650.2013.851391
CitationsScopus - 1Web of Science - 1
2013Duffull SB, Isbister GK, 'Predicting the requirement for N-acetylcysteine in paracetamol poisoning from reported dose', Clinical Toxicology, 51 772-776 (2013) [C1]
DOI10.3109/15563650.2013.830733Author URL
CitationsScopus - 5Web of Science - 5
2013Cubitt M, Armstrong J, McCoubrie D, White J, Williams V, Isbister GK, 'Point-of-care testing in snakebite: An envenomed case with false negative coagulation studies', EMERGENCY MEDICINE AUSTRALASIA, 25 372-373 (2013) [C3]
DOI10.1111/1742-6723.12089Author URL
CitationsScopus - 4Web of Science - 3
2013Kornhauser R, Isbister GK, O'Leary MA, Mirtschin P, Dunstan N, Hodgson WC, 'Cross-Neutralisation of the Neurotoxic Effects of Egyptian Cobra Venom with Commercial Tiger Snake Antivenom', BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 112 138-143 (2013) [C1]
DOI10.1111/j.1742-7843.2012.00925.xAuthor URL
CitationsScopus - 6Web of Science - 5
2013Chaisakul J, Parkington HC, Isbister GK, Konstantakopoulos N, Hodgson WC, 'Differential Myotoxic and Cytotoxic Activities of Pre-synaptic Neurotoxins from Papuan Taipan (Oxyuranus scutellatus) and Irian Jayan Death Adder (Acanthophis rugosus) Venoms', BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 112 325-334 (2013) [C1]
DOI10.1111/bcpt.12048Author URL
CitationsScopus - 1Web of Science - 1
2013Stone SF, Isbister GK, Shahmy S, Mohamed F, Abeysinghe C, Karunathilake H, et al., 'Immune Response to Snake Envenoming and Treatment with Antivenom; Complement Activation, Cytokine Production and Mast Cell Degranulation', PLOS NEGLECTED TROPICAL DISEASES, 7 (2013) [C1]
DOI10.1371/journal.pntd.0002326Author URL
CitationsScopus - 9Web of Science - 8
2012Buckley NA, Isbister GK, 'Review: Application of heat or hot water reduces pain from jellyfish stings', Annals of Internal Medicine, 157 JC6-JC12 (2012) [C3]
2012Isbister GK, O'Leary MA, Elliott M, Brown SGA, 'Tiger snake (Notechis spp) envenoming: Australian Snakebite Project (ASP-13)', Medical Journal of Australia, 197 173-177 (2012) [C1]
CitationsScopus - 11Web of Science - 11
2012Hill DJ, Lowe AJ, Hosking C, Bennett CM, Allen KJ, Axelrad C, et al., 'Reply', Journal of Allergy and Clinical Immunology, 129 262.e2-263.e2 (2012) [C3]
2012Van Gorp F, Duffull S, Hackett LP, Isbister GK, 'Population pharmacokinetics and pharmacodynamics of escitalopram in overdose and the effect of activated charcoal', British Journal of Clinical Pharmacology, 73 402-410 (2012) [C1]
CitationsScopus - 6Web of Science - 6
2012Barber CM, Isbister GK, Hodgson WC, 'Solving the 'Brown snake paradox': In vitro characterisation of Australasian snake presynaptic neurotoxin activity', Toxicology Letters, 210 318-323 (2012) [C1]
CitationsScopus - 9Web of Science - 9
2012Chaisakul J, Isbister GK, Konstantakopoulos N, Tare M, Parkington HC, Hodgson WC, 'In vivo and in vitro cardiovascular effects of Papuan taipan (Oxyuranus scutellatus) venom: Exploring ' sudden collapse'', Toxicology Letters, 213 243-248 (2012) [C1]
CitationsScopus - 4Web of Science - 2
2012Gulati A, Faed JM, Isbister GK, Duffull SB, 'Development and evaluation of a prototype of a novel clotting time test to monitor Enoxaparin', Pharmaceutical Research, 29 225-235 (2012) [C1]
CitationsScopus - 4Web of Science - 3
2012Isbister GK, Prior F, Kilham HA, 'Restricting cough and cold medicines in children', Journal of Paediatrics and Child Health, 48 91-98 (2012) [C1]
CitationsScopus - 10Web of Science - 8
2012Isbister GK, Brown SGA, 'Bites in Australian snake handlers-Australian snakebite project (ASP-15)', QJM, 105 1089-1095 (2012) [C1]
DOI10.1093/qjmed/hcs132
CitationsScopus - 6Web of Science - 5
2012Calver L, Isbister GK, 'Dexmedetomidine in the emergency department: Assessing safety and effectiveness in difficult-to-sedate acute behavioural disturbance', Emergency Medicine Journal, 29 915-918 (2012) [C1]
CitationsScopus - 1Web of Science - 1
2012Berling I, Anscombe M, Isbister GK, 'Intravenous paracetamol toxicity in a malnourished child', Clinical Toxicology, 50 74-76 (2012) [C3]
CitationsScopus - 6Web of Science - 4
2012Pycroft K, Fry BG, Isbister GK, Kuruppu S, Lawrence J, Smith AI, Hodgson WC, 'Toxinology of venoms from five Australian lesser known elapid snakes', Basic & Clinical Pharmacology & Toxicology, 111 268-274 (2012) [C1]
CitationsScopus - 4Web of Science - 4
2012Calver L, Dunlop AJ, Isbister GK, 'Individual patient assessment of methadone-induced QT prolongation with digital holter recording', Journal of Addiction Medicine, 6 92-93 (2012) [C3]
CitationsScopus - 3Web of Science - 2
2012Isbister GK, Shahmy S, Mohamed F, Abeysinghe C, Karunathilake H, Ariaratnam A, 'A randomised controlled trial of two infusion rates to decrease reactions to Antivenom', PLOS One, 7 1-6 (2012) [C1]
CitationsScopus - 16Web of Science - 12
2012Allen GE, Brown SGA, Buckley NA, O'Leary MA, Page CB, Currie BJ, et al., 'Clinical effects and antivenom dosing in brown snake (Pseudonaja spp.) envenoming: Australian Snakebite Project (ASP-14)', PLoS One, 7 e53188 (2012) [C1]
CitationsWeb of Science - 11
2012Johnston CI, O'Leary MA, Brown SGA, Currie BJ, Halkidis L, Whitaker R, et al., 'Death Adder envenoming causes neurotoxicity not reversed by antivenom - Australian Snakebite Project (ASP-16)', PLoS Neglected Tropical Diseases, 6 1-8 (2012) [C1]
CitationsScopus - 7Web of Science - 5
2011Isbister GK, Page CB, 'Early endoscopy or CT in caustic injuries: A re-evaluation of clinical practice', Clinical Toxicology, 49 641-642 (2011) [C3]
DOI10.3109/15563650.2011.604035
CitationsScopus - 1Web of Science - 2
2011Shen F, Coulter CV, Isbister GK, Duffull SB, 'A dosing regimen for immediate N-acetylcysteine treatment for acute paracetamol overdose', Clinical Toxicology, 49 643-647 (2011) [C1]
DOI10.3109/15563650.2011.604034
CitationsScopus - 6Web of Science - 6
2011Berling I, Isbister GK, Calver L, Clunas S, 'Digital Holter measurement of QT prolongation in ziprasidone overdose', Clinical Toxicology, 49 694-696 (2011) [C3]
DOI10.3109/15563650.2011.597035
CitationsScopus - 5Web of Science - 5
2011Coulter CV, Farquhar SE, McSherry CM, Isbister GK, Duffull SB, 'Methanol and ethylene glycol acute poisonings - Predictors of mortality', Clinical Toxicology, 49 900-906 (2011) [C1]
DOI10.3109/15563650.2011.630320
CitationsScopus - 9Web of Science - 10
2011Calver L, Stokes BJ, Isbister GK, 'Sedation assessment tool to score acute behavioural disturbance in the emergency department', Emergency Medicine Australasia, 23 732-740 (2011) [C1]
CitationsScopus - 5Web of Science - 5
Co-authorsBarrie Stokes
2011Maduwage K, Hodgson WC, Konstantakopoulos N, O'Leary MA, Gawarammana I, Isbister GK, 'The in vitro toxicity of venoms from South Asian hump-nosed pit vipers (Viperidae: Hypnale)', Journal of Venom Research, 2 17-23 (2011) [C1]
2011Joy JP, Coulter CV, Duffull SB, Isbister GK, 'Prediction of Torsade de Pointes from the QT Interval: Analysis of a case series of Amisulpride overdoses', Clinical Pharmacology and Therapeutics, 90 243-245 (2011) [C1]
DOI10.1038/clpt.2011.107
CitationsScopus - 10Web of Science - 8
2011Page CB, Wilson PA, Foy A, Downes MA, Whyte IM, Isbister GK, 'Life-threatening hypokalaemia associated with ibuprofen-induced renal tubular acidosis', Medical Journal of Australia, 194 613-614 (2011) [C3]
CitationsScopus - 4Web of Science - 1
2011Lane J, O'Leary MA, Isbister GK, 'Coagulant effects of black snake (Pseudechis spp.) venoms and in-vitro efficacy of commercial antivenom', Toxicon, 58 239-246 (2011) [C1]
CitationsScopus - 6Web of Science - 5
2011Isbister GK, White J, Currie BJ, O'Leary MA, Brown SGA, 'Clinical effects and treatment of envenoming by Hoplocephalus spp. snakes in Australia: Australian Snakebite Project (ASP-12)', Toxicon, 58 634-640 (2011) [C1]
DOI10.1016/j.toxicon.2011.09.013
CitationsScopus - 11Web of Science - 11
2011Isbister GK, Fan HW, 'Spider bite', The Lancet, 378 2039-2047 (2011) [C1]
CitationsScopus - 24Web of Science - 21
2011Kumar VVP, Isbister GK, Duffull SB, 'The effect of decontamination procedures on the pharmacodynamics of venlafaxine in overdose', British Journal of Clinical Pharmacology, 72 125-132 (2011) [C1]
DOI10.1111/j.1365-2125.2011.03934.x
CitationsScopus - 8Web of Science - 7
2011Casamento AJ, Isbister GK, 'Thrombotic microangiopathy in two tiger snake envenomations', Anaesthesia and Intensive Care, 39 1124-1127 (2011) [C3]
CitationsScopus - 4Web of Science - 4
2011Coulter CV, Isbister GK, Duffull SB, 'The pharmacokinetics of methanol in the presence of ethanol: A case study', Clinical Pharmacokinetics, 50 245-251 (2011) [C1]
CitationsScopus - 5Web of Science - 4
2011Isbister GK, Calver L, 'Managing aggressive and violent patients', Australian Prescriber, 34 National Prescribing Service (2011) [C3]
2011Isbister GK, Calver L, 'Hyperferritinaemia without positive HFE gene mutation', Australian Prescriber, 34 166-167 (2011) [C3]
2011Kalam Y, Isbister GK, Mirtschin P, Hodgson WC, Konstantakopoulos N, 'Validation of a cell-based assay to differentiate between the cytotoxic effects of elapid snake venoms', Journal of Pharmacological and Toxicological Methods, 63 137-142 (2011) [C1]
DOI10.1016/j.vascn.2010.09.001
CitationsScopus - 9Web of Science - 6
2011Isbister GK, Kumar VVP, 'Indications for single-dose activated charcoal administration in acute overdose', Current Opinion in Critical Care, 17 351-357 (2011) [C2]
DOI10.1097/MCC.0b013e328348bf59
CitationsScopus - 10Web of Science - 9
2011Saul ME, Thomas PA, Dosen PJ, Isbister GK, O'Leary MA, Whyte IM, et al., 'A pharmacological approach to first aid treatment for snakebite', Nature Medicine, 17 809-811 (2011) [C1]
DOI10.1038/nm.2382
CitationsScopus - 15Web of Science - 16
Co-authorsSally Mcfadden, Dirk Vanhelden
2011Buckley NA, Juurlink DN, Isbister GK, Bennett MH, Lavonas EJ, 'Hyperbaric oxygen for carbon monoxide poisoning', Cochrane Database of Systematic Reviews, - 41 (2011) [C1]
DOI10.1002/14651858.CD002041.pub3
CitationsScopus - 20Web of Science - 19
2010Isbister GK, 'Pharmacokinetic-pharmacodynamic modeling in overdose patients - Is it worth the trouble?', CLINICAL TOXICOLOGY, 48 896-897 (2010) [C1]
DOI10.3109/15563650.2010.533680Author URL
CitationsScopus - 3Web of Science - 3
2010Ireland G, Brown SGA, Buckley NA, Stormer J, Currie BJ, White J, et al., 'Changes in serial laboratory test results in snakebite patients: When can we safely exclude envenoming?', Medical Journal of Australia, 193 285-290 (2010) [C1]
CitationsScopus - 11Web of Science - 10
2010Churchman A, O'Leary MA, Buckley NA, Page CB, Tankel A, Gavaghan C, et al., 'Clinical effects of red-bellied black snake (Pseudechis porphyriacus) envenoming and correlation with venom concentrations: Australian Snakebite Project (ASP-11)', Medical Journal of Australia, 193 696-700 (2010) [C1]
CitationsScopus - 18Web of Science - 19
2010Kulawickrama S, O'Leary MA, Hodgson WC, Brown SGA, Jacoby T, Davern K, Isbister GK, 'Development of a sensitive enzyme immunoassay for measuring taipan venom in serum', Toxicon, 55 1510-1518 (2010) [C1]
DOI10.1016/j.toxicon.2010.03.003
CitationsScopus - 32Web of Science - 30
2010Isbister GK, Woods D, Alley S, O'Leary MA, Seldon M, Lincz L, 'Endogenous thrombin potential as a novel method for the characterization of procoagulant snake venoms and the efficacy of antivenom', Toxicon, 56 75-85 (2010) [C1]
DOI10.1016/j.toxicon.2010.03.013
CitationsScopus - 17Web of Science - 16
Co-authorsLisa Lincz
2010Isbister GK, Halkidis L, O'Leary MA, Whitaker R, Cullen P, Mulcahy R, et al., 'Human anti-snake venom IgG antibodies in a previously bitten snake-handler, but no protection against local envenoming', Toxicon, 55 646-649 (2010) [C1]
DOI10.1016/j.toxicon.2009.07.034
CitationsScopus - 7Web of Science - 7
2010Isbister GK, 'Snakebite doesn't cause disseminated intravascular coagulation: Coagulopathy and thrombotic microangiopathy in snake envenoming', Seminars in Thrombosis and Hemostasis, 36 444-451 (2010) [C1]
DOI10.1055/s-0030-1254053
CitationsScopus - 35Web of Science - 27
2010Isbister GK, 'How do we use drug concentration data to improve the treatment of overdose patients?', Therapeutic Drug Monitoring, 32 300-304 (2010) [C1]
DOI10.1097/FTD.0b013e3181dca280
CitationsScopus - 7Web of Science - 6
2010Isbister GK, Calver L, Page CB, Stokes BJ, Bryant J, Downes MA, 'Randomized controlled trial of intramuscular droperidol versus midazolam for violence and acute behavioral disturbance: The DORM Study', Annals of Emergency Medicine, 56 392-401 (2010) [C1]
DOI10.1016/j.annemergmed.2010.05.037
CitationsWeb of Science - 16
Co-authorsBarrie Stokes
2010Isbister GK, 'In reply', Annals of Emergency Medicine, 55 129-130 (2010) [C3]
2010Isbister GK, O'Leary MA, Hagan J, Nichols KL, Jacoby T, Davern K, et al., 'Cross-neutralisation of Australian brown snake, taipan and death adder venoms by monovalent antibodies', Vaccine, 28 798-802 (2010) [C1]
DOI10.1016/j.vaccine.2009.10.055
CitationsScopus - 15Web of Science - 17
Co-authorsJennifer Schneider
2010Page CB, Calver L, Isbister GK, 'Risperidone overdose causes extrapyramidal effects but not cardiac toxicity', Journal of Clinical Psychopharmacology, 30 387-395 (2010) [C1]
DOI10.1097/JCP.0b013e3181e5f7a5
CitationsScopus - 11Web of Science - 11
2010Isbister GK, Balit CR, Macleod D, Duffull SB, 'Amisulpride overdose is frequently associated with QT prolongation and torsades de pointes', Journal of Clinical Psychopharmacology, 30 391-395 (2010) [C1]
DOI10.1097/JCP.0b013e3181e5c14c
CitationsScopus - 20
2010Isbister GK, 'Antivenom efficacy or effectiveness: The Australian experience', Toxicology, 268 148-154 (2010) [C1]
DOI10.1016/j.tox.2009.09.013
CitationsScopus - 18Web of Science - 16
2010Winter KL, Isbister GK, McGowan S, Konstantakopoulos N, Seymour JE, Hodgson WC, 'A pharmacological and biochemical examination of the geographical variation of Chironex fleckeri venom', Toxicology Letters, 192 419-424 (2010) [C1]
DOI10.1016/j.toxlet.2009.11.019
CitationsScopus - 9Web of Science - 8
2010O'Leary MA, Isbister GK, 'A turbidimetric assay for the measurement of clotting times of procoagulant venoms in plasma', Journal of Pharmacological and Toxicological Methods, 61 27-31 (2010) [C1]
DOI10.1016/j.vascn.2009.06.004
CitationsScopus - 13Web of Science - 12
2010Calver L, Downes MA, Page CB, Bryant J, Isbister GK, 'The impact of a standardised intramuscular sedation protocol for acute behavioural disturbance in the emergency department', BMC Emergency Medicine, 10 1-7 (2010) [C1]
DOI10.1186/1471-227X-10-14
CitationsScopus - 5
2009Hodgson WC, Isbister GK, 'The application of toxins and venoms to cardiovascular drug discovery', CURRENT OPINION IN PHARMACOLOGY, 9 173-176 (2009) [C3]
DOI10.1016/j.coph.2008.11.007Author URL
CitationsScopus - 19Web of Science - 16
2009Isbister GK, Calver L, Van Gorp F, Stokes BJ, Page CB, 'Inter-rater reliability of manual QT measurement and prediction of abnormal QT,HR pairs', Clinical Toxicology, 47 884-888 (2009) [C1]
DOI10.3109/15563650903333820
CitationsScopus - 13Web of Science - 11
Co-authorsBarrie Stokes
2009Page CB, Hacket LP, Isbister GK, 'The Use of High-Dose insulin-glucose euglycemia in beta-blocker overdose: A case report', Journal of Medical Toxicology, 5 139-143 (2009) [C1]

The management of life-threatening beta-blocker toxicity and its associated low cardiac output state is clinically challenging. Previous case reports and case series describe the ... [more]

The management of life-threatening beta-blocker toxicity and its associated low cardiac output state is clinically challenging. Previous case reports and case series describe the use of hyperinsulinemia/euglycemia therapy in mono-ingestions of calcium channel blockers and mixed ingestions, including calcium channel and beta-blockers. In this case report we describe the use of high-dose insulin (10 IU/kg per hour) in a case of massive metoprolol ingestion (5 g) in which hypotension was unresponsive to conventional therapies. Although the metoprolol concentrations measured in plasma were approximately 100-200 times therapeutic concentrations, the pharmacokinetics appeared to be similar to therapeutic metoprolol dosing.

DOI10.1007/BF03161225
CitationsScopus - 14
2009Canale E, Isbister GK, Currie BJ, 'Investigating pressure bandaging for snakebite in a simulated setting: Bandage type, training and the effect of transport', EMERGENCY MEDICINE AUSTRALASIA, 21 184-190 (2009) [C1]
DOI10.1111/j.1742-6723.2009.01180.xAuthor URL
CitationsScopus - 14Web of Science - 11
2009Downes MA, Healy P, Page CB, Bryant J, Isbister GK, 'Structured team approach to the agitated patient in the emergency department', Emergency Medicine Australasia, 21 196-202 (2009) [C1]
DOI10.1111/j.1742-6723.2009.01182.x
CitationsScopus - 17Web of Science - 14
2009Loten C, Isbister GK, Jamcotchian MA, Hullick C, McElduff P, Attia JR, Marley J, 'Adverse outcomes following emergency department discharge of patients with possible acute coronary syndrome', Emergency Medicine Australasia, 21 455-464 (2009) [C1]
DOI10.1111/j.1742-6723.2009.01229.x
CitationsScopus - 5Web of Science - 5
Co-authorsJohn Attia
2009Clunas S, Whitaker R, Ritchie N, Upton J, Isbister GK, 'Reviewing deaths in the emergency department: Deaths in the department or deaths within 48 h', Emergency Medicine Australasia, 21 117-123 (2009) [C1]
DOI10.1111/j.1742-6723.2009.01166.x
CitationsScopus - 3Web of Science - 2
2009Gildenhuys J, Lee M, Isbister GK, 'Does implementation of a paediatric asthma clinical practice guideline worksheet change clinical practice?', International Journal of Emergency Medicine, 2 33-39 (2009) [C1]
DOI10.1007/s12245-008-0063-x
CitationsScopus - 11
2009Isbister GK, Scorgie FE, Seldon MR, Lincz L, 'Clinical relevance of brown snake (Pseudonaja spp) factor V escaping hemostatic regulation', Blood, 114 2563 (2009) [C3]
DOI10.1182/blood-2009-06-227306
CitationsScopus - 1
Co-authorsLisa Lincz
2009Wajima T, Isbister GK, Duffull SB, 'A comprehensive model for the humoral coagulation network in humans', Clinical Pharmacology & Therapeutics, 86 290-298 (2009) [C1]
DOI10.1038/clpt.2009.87
CitationsScopus - 25Web of Science - 23
2009Kumar VVP, Oscarsson S, Friberg LE, Isbister GK, Hackett LP, Duffull SB, 'The effect of decontamination procedures on the pharmacokinetics of venlafaxine in overdose', Clinical Pharmacology and Therapeutics, 86 403-410 (2009) [C1]
DOI10.1038/clpt.2009.114
2009Gan M, O'Leary MA, Brown SGA, Jacoby T, Spain D, Tankel A, et al., 'Envenoming by the rough-scaled snake (Tropidechis carinatus): a series of confirmed cases', MEDICAL JOURNAL OF AUSTRALIA, 191 183-186 (2009) [C1]
Author URL
CitationsScopus - 11Web of Science - 11
2009Calver LA, Stokes BJ, Isbister GK, 'The dark side of the moon', Medical Journal of Australia, 191 692-694 (2009) [C1]
CitationsScopus - 3Web of Science - 4
Co-authorsBarrie Stokes
2009O'Leary MA, Kornhauser RS, Hodgson WC, Isbister GK, 'An examination of the activity of expired and mistreated commercial Australian antivenoms', TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 103 937-942 (2009) [C1]
DOI10.1016/j.trstmh.2008.11.011Author URL
CitationsScopus - 5Web of Science - 3
2009O'Leary MA, Isbister GK, 'Commercial monovalent antivenoms in Australia are polyvalent', Toxicon, 54 192-195 (2009) [C1]
DOI10.1016/j.toxicon.2009.04.004
CitationsScopus - 16Web of Science - 15
2009Stone SF, Cotterell C, Isbister GK, Holdgate A, Brown SGA, Emergency Department Anaphylaxis Investigators, 'Elevated serum cytokines during human anaphylaxis: Identification of potential mediators of acute allergic reactions', Journal of Allergy and Clinical Immunology, 124 786-792 (2009) [C1]
DOI10.1016/j.jaci.2009.07.055
CitationsScopus - 41Web of Science - 41
2009Isbister GK, 'Procoagulant Snake Toxins: Laboratory Studies, Diagnosis, and Understanding Snakebite Coagulopathy', SEMINARS IN THROMBOSIS AND HEMOSTASIS, 35 93-103 (2009) [C1]
DOI10.1055/s-0029-1214152Author URL
CitationsScopus - 32Web of Science - 29
2009Van Gorp F, Whyte IM, Isbister GK, 'Clinical and ECG effects of escitalopram overdose', Annals of Emergency Medicine, 54 404-408 (2009) [C1]
DOI10.1016/j.annemergmed.2009.04.016
CitationsScopus - 30Web of Science - 24
2009Isbister GK, Duffull SB, 'Quetiapine overdose: Predicting intubation, duration of ventilation, cardiac monitoring and the effect of activated charcoal', International Clinical Psychopharmacology, 24 174-180 (2009) [C1]
DOI10.1097/yic.0b013e32832bb078
CitationsScopus - 22Web of Science - 21
2009Isbister GK, 'Electrocardiogram changes and arrhythmias in venlafaxine overdose', British Journal of Clinical Pharmacology, 67 572-576 (2009) [C1]
DOI10.1111/j.1365-2125.2009.03382.x
CitationsScopus - 25Web of Science - 22
2009Brown SGA, Caruso N, Borland ML, McCoubrie DL, Celenza A, Isbister GK, 'Clotting factor replacement and recovery from snake venom-induced consumptive coagulopathy', INTENSIVE CARE MEDICINE, 35 1532-1538 (2009) [C1]
DOI10.1007/s00134-009-1556-7Author URL
CitationsScopus - 16Web of Science - 10
2009Winter KL, Isbister GK, Jacoby T, Seymour JE, Hodgson WC, 'An in vivo comparison of the efficacy of CSL box jellyfish antivenom with antibodies raised against nematocyst-derived Chironex fleckeri venom', TOXICOLOGY LETTERS, 187 94-98 (2009) [C1]
DOI10.1016/j.toxlet.2009.02.008Author URL
CitationsScopus - 11Web of Science - 11
2009Isbister GK, 'Commentary: Treating redback spider envenoming - the evidence, the interpretation and current thinking', JOURNAL OF PAEDIATRICS AND CHILD HEALTH, 45 477-477 (2009) [C3]
Author URL
2009Konstantakopoulos N, Isbister GK, Seymour JE, Hodgson WC, 'A cell-based assay for screening of antidotes to, and antivenom against Chironex fleckeri (box jellyfish) venom', Journal of Pharmacological and Toxicological Methods, 59 166-170 (2009) [C1]
DOI10.1016/j.vascn.2009.02.003
CitationsScopus - 16
2009Page CB, Duffull SB, Whyte IM, Isbister GK, 'Promethazine overdose: Clinical effects, predicting delirium and the effect of charcoal', QJM - An International Journal of Medicine, 102 123-131 (2009) [C1]
DOI10.1093/qjmed/hcn153
CitationsScopus - 14Web of Science - 12
2009Isbister GK, Duffull SB, Brown SGA, 'Failure of antivenom to improve recovery in Australian snakebite coagulopathy', QJM-AN INTERNATIONAL JOURNAL OF MEDICINE, 102 563-568 (2009) [C1]
DOI10.1093/qjmed/hcp081Author URL
CitationsScopus - 33Web of Science - 24
2008Kuruppu S, Smith AI, Isbister GK, Hodgson WC, 'Neurotoxins from Australo-Papuan elapids: A biochemical and pharmacological perspective', CRITICAL REVIEWS IN TOXICOLOGY, 38 73-86 (2008) [C3]
DOI10.1080/10408440701703964Author URL
CitationsScopus - 18Web of Science - 18
2008Isbister GK, Brown SGA, Miller M, Tankel A, MacDonald E, Stokes BJ, et al., 'A randomised controlled trial of intramuscular vs. intravenous antivenom for latrodectism: The RAVE study', QJM, 101 557-565 (2008) [C1]
DOI10.1093/qjmed/hcn048
CitationsScopus - 15Web of Science - 15
Co-authorsBarrie Stokes
2008Page C, Isbister G, 'Dolasetron and QT interval', EMERGENCY MEDICINE JOURNAL, 25 706-706 (2008) [C3]
Author URL
CitationsScopus - 1
2008Knott JC, Isbister GK, 'Sedation of agitated patients in the emergency department', EMERGENCY MEDICINE AUSTRALASIA, 20 97-100 (2008) [C3]
DOI10.1111/j.1742-6723.2008.01063.xAuthor URL
CitationsScopus - 9Web of Science - 7
2008Currie BJ, Canale E, Isbister GK, 'Effectiveness of pressure-immobilization first aid for snakebite requires further study', EMERGENCY MEDICINE AUSTRALASIA, 20 267-270 (2008) [C1]
DOI10.1111/j.1742-6723.2008.01093.xAuthor URL
CitationsScopus - 9Web of Science - 10
2008Chan AS, Isbister GK, Kirkpatrick CM, Duffull SB, 'Assessing risk of a prolonged QT interval-a survey of emergency physicians.', International journal of emergency medicine, 1 35-41 (2008) [C2]
DOI10.1007/s12245-008-0014-6
2008Isbister GK, Burns J, Prior F, Ouvrier RA, 'Safety of nitrous oxide administration in patients with Charcot-Marie-Tooth disease', JOURNAL OF THE NEUROLOGICAL SCIENCES, 268 160-162 (2008) [C1]
DOI10.1016/j.jns.2007.12.004Author URL
CitationsScopus - 2Web of Science - 1
2008Isbister GK, Brown SG, MacDonald E, White J, Currie BJ, 'Current use of Australian snake antivenoms and frequency of immediate-type hypersensitivity reactions and anaphylaxis', MEDICAL JOURNAL OF AUSTRALIA, 188 473-476 (2008) [C1]
Author URL
CitationsScopus - 47Web of Science - 43
2008Herzig V, Khalife AA, Chong Y, Isbister GK, Currie BJ, Churchill TB, et al., 'Intersexual variations in Northern (Missulena pruinosa) and Eastern (M-bradleyi) mouse spider venom', TOXICON, 51 1167-1177 (2008) [C1]
DOI10.1016/j.toxicon.2008.02.001Author URL
CitationsScopus - 13Web of Science - 13
2008Tanos PP, Isbister GK, Lalloo DG, Kirkpatrick CMJ, Duffull SB, 'A model for venom-induced consumptive coagulopathy in snake bite', TOXICON, 52 769-780 (2008) [C1]
DOI10.1016/j.toxicon.2008.08.013Author URL
CitationsScopus - 20Web of Science - 18
2008Vetter RS, Isbister GK, 'Medical aspects of spider bites', ANNUAL REVIEW OF ENTOMOLOGY, 53 409-429 (2008) [C3]
DOI10.1146/annurev.ento.53.103106.093503Author URL
CitationsScopus - 60Web of Science - 48
2008Dowling J, Isbister GK, Kirkpatrick CMJ, Naidoo D, Graudins A, 'Population pharmacokinetics of intravenous, intramuscular, and intranasal naloxone in human volunteers', THERAPEUTIC DRUG MONITORING, 30 490-496 (2008) [C1]
Author URL
CitationsScopus - 17Web of Science - 14
2008Downes M, Page C, Isbister G, 'Response to "Use of Lipid Emulsion in the Resuscitation of a Patient With Prolonged Cardiovascular Collapse After Overdose of Bupropion and Lamotrigine"', ANNALS OF EMERGENCY MEDICINE, 51 794-795 (2008) [C3]
DOI10.1016/i.annemergmed.2007.11.042Author URL
CitationsScopus - 5Web of Science - 3
2008Isbister GK, Stokes BJ, Buckle NA, Duffull SB, 'Effect of activated charcoal on citalopram-induced QT prolongation - Reply', Annals of Emergency Medicine, 52 87-88 (2008) [C3]
DOI10.1016/j.annemergmed.2007.11.046
Co-authorsBarrie Stokes
2008Isbister GK, O'Leary M, Miller MK, Brown SGA, Ramasamy S, James R, Schneider JJ, 'A comparison of serum antivenom concentrations after intravenous and intramuscular administration of redback (widow) spider antivenom', British Journal of Clinical Pharmacology, 65 139-143 (2008) [C1]
DOI10.1111/j.1365-2125.2007.03004.x
CitationsScopus - 15Web of Science - 13
Co-authorsJennifer Schneider
2008Isbister G, 'Marine animal injuries - Dr Geoffrey Isbister, comments', AUSTRALIAN PRESCRIBER, 31 32-32 (2008) [C3]
Author URL
2008Winter KL, Isbister GK, Schneider JJ, Konstantakopoulos N, Seymour JE, Hodgson WC, 'An examination of the cardiovascular effects of an 'Irukandji' jellyfish, Alatina nr mordens', Toxicology Letters, 179 118-123 (2008) [C1]
DOI10.1016/j.toxlet.2008.04.011
CitationsScopus - 18Web of Science - 18
Co-authorsJennifer Schneider
2007Isbister GK, 'Managing injuries by venomous sea creatures in Australia', Australian Prescriber, 30 117-121 (2007)

Marine injuries or stings are common, but the majority cause only minor effects and do not require medical intervention. Injuries from venomous marine creatures can be divided int... [more]

Marine injuries or stings are common, but the majority cause only minor effects and do not require medical intervention. Injuries from venomous marine creatures can be divided into jellyfish stings due to contact with nematocysts, and penetrating injuries from spiny fish, stingrays and sea urchins. Box jellyfish are the most dangerous and may cause severe and potentially life-threatening effects. First aid for jellyfish stings includes removal of the tentacles, and hot water immersion for bluebottles or vinegar for major box jellyfish. In addition to vinegar, major box jellyfish stings are treated with analgesia and local dressings. Early resuscitation is required in the rare severe cases. Irukandji syndrome causes severe generalised pain associated with autonomic effects with little local pain or reaction. Treatment is symptomatic but may require large amounts of analgesia. Spiny fish and stingrays cause a combination of traumatic injury and venom-mediated effects. First aid is hot water immersion and treatment includes analgesia, thorough wound cleaning and regular review for secondary infection. Stingray injuries can be associated with significant trauma and sometimes result in penetrating abdominal or thoracic injury.

CitationsScopus - 1
2007Isbister GK, Friberg LE, Duffull SB, 'Reply to Dr. Megarbane et al. regarding "Pharmacokinetic/pharmacodynamic modelling of cardiac toxicity in venlafaxine overdose"', INTENSIVE CARE MEDICINE, 33 197-197 (2007)
DOI10.1007/s00134-006-0418-9Author URL
CitationsWeb of Science - 1
2007Isbister GK, Friberg LE, Duffull SB, 'Application of pharmacokinetic-pharmacodynamic modeling in management of QT abnormalities after citalopram overdose. Reply to A. Manini', INTENSIVE CARE MEDICINE, 33 739-739 (2007)
DOI10.1007/s00134-006-0506-xAuthor URL
2007Winter KL, Fernando R, Ramasamy S, Seymour JE, Isbister GK, Hodgson WC, 'The in vitro vascular effects of two chirodropid (Chironex fleckeri and Chiropsella bronzie) venoms', TOXICOLOGY LETTERS, 168 13-20 (2007)
DOI10.1016/j.toxlet.2006.10.011Author URL
CitationsScopus - 19Web of Science - 20
2007Balit CR, Gilmore SP, Isbister GK, 'Unintentional paediatric ingestions of angiotensin converting enzyme inhibitors and angiotensin II receptor antagonists', JOURNAL OF PAEDIATRICS AND CHILD HEALTH, 43 686-688 (2007)
DOI10.1111/j.1440-1754.2007.01188.xAuthor URL
CitationsScopus - 3Web of Science - 5
2007Ramjan KA, Williams AJ, Isbister GK, Elliott EJ, ''Red as a beet and blind as a bat' Anticholinergic delirium in adolescents: Lessons for the paediatrician', JOURNAL OF PAEDIATRICS AND CHILD HEALTH, 43 779-780 (2007)
DOI10.1111/j.1440-1754.2007.01220.xAuthor URL
CitationsScopus - 2Web of Science - 2
2007Isbister GK, Little M, Cull G, McCoubrie D, Lawton P, Szabo F, et al., 'Thrombotic microangiopathy from Australian brown snake (Pseudonaia) envenoming', INTERNAL MEDICINE JOURNAL, 37 523-528 (2007)
DOI10.1111/j.1445-5994.2007.01407.xAuthor URL
CitationsScopus - 23Web of Science - 20
2007Isbister GK, 'Safety of i.v. administration of redback spider antivenom', INTERNAL MEDICINE JOURNAL, 37 820-U1 (2007)
DOI10.1111/j.1445-5994.2007.01513.xAuthor URL
CitationsScopus - 4Web of Science - 4
2007Chan A, Isbister GK, Kirkpatrick CMJ, Dufful SB, 'Drug-induced QT prolongation and torsades de pointes: evaluation of a QT nomogram', QJM-AN INTERNATIONAL JOURNAL OF MEDICINE, 100 609-615 (2007)
DOI10.1093/qjmed/hcm072Author URL
CitationsScopus - 70Web of Science - 65
2007Isbister GK, Mills K, Friberg LE, Hodge M, O'Connor E, Patel R, et al., 'Human methyl parathion poisoning', CLINICAL TOXICOLOGY, 45 956-960 (2007)
DOI10.1080/15563650701232745Author URL
CitationsScopus - 8Web of Science - 7
2007Isbister GK, Friberg LE, Hackett LP, Duffull SB, 'Pharmacokinetics of quetiapine in overdose and the effect of activated charcoal', CLINICAL PHARMACOLOGY & THERAPEUTICS, 81 821-827 (2007)
DOI10.1038/sj.clpt.6100193Author URL
CitationsScopus - 30Web of Science - 29
2007Jansen M, McLeod MG, White J, Isbister GK, 'Spotted black snake (Pseudechis guttatus) envenoming', Medical Journal of Australia, 186 41-42 (2007) [C1]
CitationsScopus - 4Web of Science - 3
2007Isbister GK, Buckley NA, Whyte IM, 'Serotonin toxicity: a practical approach to diagnosis and treatment', Medical Journal of Australia, 187 361-365 (2007) [C1]
CitationsScopus - 88Web of Science - 64
2007Brown SGA, Isbister GK, Stokes BJ, 'Route of administration of redback spider bite antivenom: Determining clinician beliefs to facilitate Bayesian analysis of a clinical trial', EMA - Emergency Medicine Australasia, 19 458-463 (2007) [C1]
DOI10.1111/j.1742-6723.2007.01014.x
CitationsScopus - 2Web of Science - 3
Co-authorsBarrie Stokes
2007Winter KL, Isbister GK, Seymour JE, Hodgson WC, 'An in vivo examination of the stability of venom from the Australian box jellyfish Chironex fleckeri', TOXICON, 49 804-809 (2007)
DOI10.1016/j.toxicon.2006.11.031Author URL
CitationsScopus - 15Web of Science - 15
2007Isbister G, O'Leary M, Schneider JJ, Brown S, Currie B, 'Efficacy of antivenom against the procoagulant effect of Australian brown snake (Pseudonaja sp.) venom: In vivo and in vitro studies', Toxicon, 49 57-67 (2007) [C1]
DOI10.1016/j.toxicon.2006.09.007
CitationsScopus - 29Web of Science - 26
Co-authorsJennifer Schneider
2007O'Leary MA, Schneider JJ, Krishnan BP, Lavis C, McKendry A, Ong LK, Isbister GK, 'Cross-neutralisation of Australian brown and tiger snake venoms with commercial antivenoms: Cross-reactivity or antivenom mixtures?', Toxicon, 50 206-213 (2007) [C1]
DOI10.1016/j.toxicon.2007.03.014
CitationsScopus - 13Web of Science - 10
Co-authorsJennifer Schneider, Linkooi Ong
2007Isbister GK, Friberg LE, Stokes BJ, Buckley NA, Lee C, Gunja N, et al., 'Activated Charcoal Decreases the Risk of QT Prolongation After Citalopram Overdose', Annals of Emergency Medicine, 50 593.e46-600.e46 (2007) [C1]
DOI10.1016/j.annemergmed.2007.03.009
CitationsScopus - 24Web of Science - 20
Co-authorsBarrie Stokes
2007Morgan M, Hackett LP, Isbister GK, 'Olanzapine overdose: a series of analytically confirmed cases', International Clinical Psychopharmacology, 22 183-186 (2007) [C1]
DOI10.1097/YIC.0b013e32805aedf5
CitationsScopus - 17Web of Science - 16
2006Isbister GK, Tankel AS, White J, Little M, Brown SGA, Spain DJ, et al., 'High rate of immediate systemic hypersensitivity reactions to tiger snake antivenom', MEDICAL JOURNAL OF AUSTRALIA, 184 419-420 (2006)
Author URL
CitationsScopus - 3Web of Science - 3
2006Isbister GK, Murray L, John S, Hackett LP, Haider T, O'Mullane P, et al., 'Amisulpride deliberate self-poisoning causing severe cardiac toxicity including QT prolongation and torsades de pointes', MEDICAL JOURNAL OF AUSTRALIA, 184 354-356 (2006)
Author URL
CitationsScopus - 19Web of Science - 16
2006Loten C, Stokes BJ, Worsley D, Seymour JE, Jiang S, Isbister GK, 'Randomised controlled trial of hot water (45 degrees C) immersion versus ice packs for pain relief in bluebottle stings', Medical Journal of Australia, 184 329-333 (2006) [C1]
CitationsScopus - 52Web of Science - 44
Co-authorsBarrie Stokes
2006Isbister GK, Williams V, Brown SGA, White J, Currie B, 'Clinically applicable laboratory end-points for treating snakebite coagulopathy', Pathology, 38 568-672 (2006) [C1]
DOI10.1080/00313020601024045
CitationsScopus - 16Web of Science - 15
2006Vetter RS, Isbister GK, 'Verified bites by the woodlouse spider, Dysdera crocata', TOXICON, 47 826-829 (2006)
DOI10.1016/j.toxicon.2006.02.002Author URL
CitationsScopus - 4Web of Science - 5
2006O'Leary MA, Isbister GK, Schneider JJ, Brown SGA, Currie BJ, 'Enzyme immunoassays in brown snake (Pseudonaja spp.) envenoming: Detecting venom, antivenom and venom-antivenom complexes', Toxicon, 48 4-11 (2006) [C1]
DOI10.1016/j.toxicon.2006.04.001
CitationsScopus - 30Web of Science - 29
Co-authorsJennifer Schneider
2006Friberg LE, Isbister GK, Duffull SB, 'Pharmacokinetic Pharmacodynamic Modelling of QT Interval Prolongation following Citalopram Overdoses', British Journal of Clinical Pharmacology, 61 177-190 (2006) [C1]
DOI10.1111/j.1365-2125.2005.02546.x
CitationsScopus - 48Web of Science - 43
2006Isbister GK, 'Snake bite: A current approach to management', Australian Prescriber, 29 125-129 (2006)

Snake envenoming is uncommon but potentially life-threatening. It is characterised by systemic effects including coagulopathy, neurotoxicity, myotoxicity and renal impairment. Pre... [more]

Snake envenoming is uncommon but potentially life-threatening. It is characterised by systemic effects including coagulopathy, neurotoxicity, myotoxicity and renal impairment. Pressure immobilisation bandaging is safe and appears to be effective first aid if applied correctly soon after the bite. Each Australian snake causes a characteristic clinical syndrome which can be used with information about the geographical distribution of snakes to determine which snake is involved when a patient is envenomed. Snake venom detection kits are available to help identify the causative snake. Antivenoms are available for the five major groups of snakes and are the mainstay of therapy in patients with systemic envenoming. Antivenom should be administered by slow intravenous infusion in a critical care area. Serious adverse reactions to antivenoms are uncommon.

CitationsScopus - 9
2006Isbister GK, 'Spider bite: A current approach to management', Australian Prescriber, 29 156-158 (2006)

Although spider bite is common, most spider bites cause minor effects and do not require treatment. More significant effects result from redback and, less commonly, from funnel-we... [more]

Although spider bite is common, most spider bites cause minor effects and do not require treatment. More significant effects result from redback and, less commonly, from funnel-web spider bites. Redback spider envenoming causes local, radiating and regional pain, sometimes associated with local or regional diaphoresis, non-specific systemic features, and less commonly, other autonomic or neurological effects. Antivenom is recommended for severe or persistent pain and systemic effects. Funnel-web spider envenoming can rapidly cause life-threatening effects, but it can be treated effectively with antivenom. Envenoming is characterised by excessive autonomic activity, neuromuscular excitation and pulmonary oedema. Clinical effects attributed to suspected spider bites such as ulcers, should be thoroughly investigated for other causes including infectious, inflammatory, vascular and neoplastic conditions.

CitationsScopus - 2
2006Isbister GK, Friberg LE, Duffull SB, 'Application of pharmacokinetic-pharmacodynamic modelling in management of QT abnormalities after citalopram overdose', Intensive Care Medicine, 32 1060-1065 (2006) [C1]
DOI10.1007/s00134-006-0183-9
CitationsScopus - 32Web of Science - 28
2006Balit CR, Lynch AM, Gilmore SP, Murray L, Isbister GK, 'Lignocaine and chlorhexidine toxicity in children resulting from mouth paint ingestion: a bottling problem', Journal of Paediatrics and Child Health, 42 350-353 (2006) [C1]
DOI10.1111/j.1440-1754.2006.00871.x
CitationsScopus - 10Web of Science - 9
2006Isbister GK, Hooper MR, Dowsett R, Maw G, Murray L, White J, 'Collett''s Snake (Pseudechis colletti) envenoming in snake handlers', QJM: an international journal of medicine, 99 109-115 (2006) [C1]
DOI10.1093/qjmed/hcl007
CitationsScopus - 16Web of Science - 17
2006Sibbritt DW, Isbister GK, Walker RJ, 'Emergency department performance indicators that encompass the patient journey', Quality Management in Health Care, 15 27-38 (2006) [C2]
CitationsScopus - 12
2006Seifert SA, Keyler D, Isbister G, McNally J, Martin TG, 'ACMT Position Statement: Institutions housing venomous animals.', Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2 118-119 (2006)
CitationsScopus - 2
2006Isbister GK, 'Clinical trials in toxinology: More than a discussion between friends?', EMA - Emergency Medicine Australasia, 18 4-6 (2006)
DOI10.1111/j.1742-6723.2006.00797.x
CitationsScopus - 2
2006Leung NY, Whyte IM, Isbister GK, 'Baclofen overdose: Defining the spectrum of toxicity', EMA - Emergency Medicine Australasia, 18 77-82 (2006) [C1]
DOI10.1111/j.1742-6723.2006.00805.x
CitationsScopus - 31
2006Vetter RS, Isbister GK, Bush SP, Boutin LJ, 'Verified Bites By Yellow Sac Spiders (Genus Cheiracanthium) In The United States And Australia: Where Is The Necrosis?', American Journal of Tropical Medicine and Hygiene, 74 1043-1048 (2006) [C1]
CitationsScopus - 19Web of Science - 14
2005Friberg LE, Isbister GK, Hackett LP, Duffull SB, 'The Population Pharmacokinetics of Citalopram after Deliberate Self-Poisoning: a Bayesian approach', Journal of Pharmacokinetics and Pharmacodynamics, 32 571-605 (2005) [C1]
DOI10.1007/s10928-005-0022-6
CitationsScopus - 39Web of Science - 33
2005Isbister GK, Balit CR, Kilham HA, 'Antipsychotic poisoning in young children: A systematic review', Drug Safety, 28 1029-1044 (2005)

The aim of this review was to determine the spectrum and severity of effects of unintentional antipsychotic poisoning in children. A computerised literature search of MEDLINE (196... [more]

The aim of this review was to determine the spectrum and severity of effects of unintentional antipsychotic poisoning in children. A computerised literature search of MEDLINE (1966 to February 2005) and EMBASE (1980 to February 2005) was undertaken. The Internet was searched using URL: www.google.com. The proceedings of the North American Congress of Clinical Toxicology (NACCT) and the European Association of Poisons Centres and Clinical Toxicologists (EAPCCT) were hand searched. All cases of unintentional antipsychotic (all classes) poisoning in children aged 0-6 years were included. The data extracted included the age, weight, antipsychotic, dose, clinical effects, treatment and outcomes. The toxic dose was estimated as the lowest dose causing objective adverse effects. Sixty-eight reports were identified. Few contained all of the required information. Most of the case series included multiple antipsychotics with limited information on individual drugs or all ages with limited paediatric information. For most antipsychotics the ingestion of one tablet caused symptoms that were sometimes severe and usually lasted from 1 to 3 days. Extrapyramidal symptoms (EPS) were often delayed for up to 12-24 hours. Chlorpromazine caused CNS depression, hypotension and miosis; EPS and cardiac effects were rare, and the toxic dose was estimated to be 15 mg/kg. Haloperidol caused drowsiness (rarely coma) and over one-half of patients had neuromuscular effects (mainly EPS), with a toxic dose estimated at 0.15 mg/kg. Thioridazine caused CNS depression and potentially cardiac effects, with a toxic dose of 1.4 mg/kg. Atypical antipsychotics caused significant CNS depression (except risperidone); EPS were less common. Toxic doses were clozapine 2.5 mg/kg, olanzapine 0.5 mg/kg and aripiprazole 3 mg/kg. EPS responded to anticholinergic drug treatment. In summary, unintentional antipsychotic ingestion in children can cause severe effects that last 1-3 days, often with one tablet. Children potentially ingesting a toxic dose or who are symptomatic should be considered for assessment in hospital. Most cases resolve with good supportive care. Toxic doses are only estimates that are based on limited data and should be used with caution until prospective studies are undertaken. © 2005 Adis Data Information BV. All rights reserved.

DOI10.2165/00002018-200528110-00004
CitationsScopus - 12
2005Isbister GK, White J, Currie BJ, Bush SP, Vetter RS, Warrell DA, 'Spider bites: Addressing mythology and poor evidence (letter)', American Journal of Tropical Medicine and Hygiene, 72 361-364 (2005) [C3]
CitationsScopus - 9Web of Science - 6
2005Kuruppu S, Isbister GK, Hodgson WC, 'Phospholipase A2 dependent effects of the venom from the New Guinean small-eyed snake Micropechis ikaheka', Muscle and Nerve, 32 81-87 (2005) [C1]
DOI10.1002/mus.20334
CitationsScopus - 4
2005Isbister GK, Vetter RS, 'Loxoscelism and necrotic arachnidism: More myths and minor corrections (letter)', Annals of Emergency Medicine, 46 205-206 (2005) [C3]
CitationsScopus - 1Web of Science - 1
2005Isbister GK, Buckley NA, 'The pathophysiology of serotonin toxicity in animals and humans - Implications for diagnosis and treatment', Clinical Neuropharmacology, 28 205-214 (2005) [C1]
CitationsScopus - 97Web of Science - 80
2005Isbister GK, Seymour JS, Hodgson WC, 'The in Vivo Cardiovascular effects of the Lrukandji Jellyfish (Carukia barnesi) Nematocyst Venom and a Tentacle Extract in rats', Toxicology Letters, 155 135-141 (2005) [C1]
DOI10.1016/j.toxlet.2004.09.004
CitationsScopus - 43Web of Science - 41
2005Ramasamy S, Isbister GK, Seymour JS, Hodgson WC, 'Pharmacologically Distinct Cardiovascular Effects of Box Jellyfish (Chironex fleckeri) Venom and a Tentacle-only extract in rats', Toxicology Letters, 155 219-226 (2005) [C1]
DOI10.1016/j.toxlet.2004.09.018
CitationsScopus - 40Web of Science - 40
2005Thom SR, Buckley NA, Isbister GK, Juurlink DN, 'Hyperbaric oxygen therapy for carbon monoxide poisoning', Toxicological Reviews, 24 157-160 (2005)
DOI10.2165/00139709-200524030-00006
CitationsScopus - 4
2005Buckley NA, Isbister GK, Stokes BJ, Juurlink DN, 'Hyperbaric oxygen for carbon monoxide poisoning: A systematic review and critical analysis of the evidence', Toxicological Reviews, 24 75-92 (2005) [C1]
DOI10.2165/00139709-200524020-00002
CitationsScopus - 56
Co-authorsBarrie Stokes
2005Isbister GK, Gray MR, Balit CR, Raven RJ, Stokes BJ, Porges K, et al., 'Funnel-web spider bite: a systematic review of recorded clinical cases', Medical Journal of Australia, 182 407-411 (2005) [C1]
CitationsScopus - 17Web of Science - 12
Co-authorsBarrie Stokes
2005Downes MA, Whyte IM, Isbister GK, 'QTc abnormalities in deliberate self-poisoning with moclobemide', Internal Medicine Journal, 35 388-391 (2005) [C1]
DOI10.1111/j.1445-5994.2005.00850.x
CitationsScopus - 4Web of Science - 3
2005Isbister GK, 'Snake antivenom research: the importance of case definition', EMERGENCY MEDICINE JOURNAL, 22 399-400 (2005)
DOI10.1136/emj.2004.022251Author URL
CitationsScopus - 5Web of Science - 5
2005Isbister GK, Kiernan MC, 'Neurotoxic Marine Poisoning', Lancet Neurology, 4 219-228 (2005) [C1]
DOI10.1016/S1474-4422(05)70041-7
CitationsScopus - 108Web of Science - 77
2005Gosselin S, Isbister GK, 'Re: Treatment of accidental intrathecal methotrexate overdose', JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 97 609-610 (2005)
DOI10.1093/jnci/dji108Author URL
CitationsScopus - 3Web of Science - 2
2005Little M, Isbister G, 'Big black spider bite from the desert region of Western Australia [3] (multiple letters)', EMA - Emergency Medicine Australasia, 17 181-183 (2005)
2005Isbister GK, Buckley NA, 'Clomipramine and neuroleptic malignant syndrome - Literature on adverse reactions to psychotropic drugs continues to confuse', BMJ-BRITISH MEDICAL JOURNAL, 330 790-791 (2005)
DOI10.1136/bmj.330.7494.790-cAuthor URL
CitationsScopus - 3Web of Science - 3
2005Isbister GK, Hooper J, 'Clinical effects of stings by sponges of the genus Tedania and a review of sponge stings worldwide', Toxicon, 46 782-785 (2005) [C1]
DOI10.1016/j.toxicon.2005.08.009
CitationsScopus - 10Web of Science - 9
2005Ramasamy S, Isbister GK, Seymour JS, Hodgson WC, 'The In Vivo Cardiovascular Effects of an Australasian Box Jellyfish (Chiropsalmus sp.) Venom in Rats', Toxicon, 45 321-327 (2005) [C1]
DOI10.1016/j.toxicon.2004.11.002
CitationsScopus - 17Web of Science - 16
2004Isbister GK, 'Sublingual glyceryl trinitrate as prehospital treatment for hypertension in Irukandji syndrome', MEDICAL JOURNAL OF AUSTRALIA, 180 483-483 (2004)
Author URL
CitationsScopus - 2Web of Science - 1
2004Isbister GK, 'Mouse spider bites (Missulena spp.) and their medical importance', MJA, 180 225-227 (2004) [C1]
CitationsScopus - 13Web of Science - 9
2004Isbister GK, 'Antivenom, anecdotes and evidence', MJA, 181 685-686 (2004) [C1]
CitationsScopus - 4Web of Science - 4
2004Isbister GK, Ramasamy S, Seymour JE, Hodgson WC, 'Verapamil treatment in severe Chironex fleckeri stings - Reply', TOXICON, 44 819-820 (2004)
DOI10.1016/j.toxicon.2004.08.014Author URL
2004Burnett JW, Calton GJ, Isbister GK, Ramasamy S, Seymour JE, Hodgson WC, 'The case for verapamil use in alarming jellyfish stings remains (multiple letters)', Toxicon, 44 817-820 (2004)
DOI10.1016/j.toxicon.2004.08.003
CitationsScopus - 4
2004O'Leary MA, Schneider JJ, Isbister GK, 'Use of high performance liquid chromatography to measure tetrodotoxin in serum and urine of poisoned patients', Toxicon, 44 549-553 (2004) [C1]
DOI10.1016/j.toxicon.2004.07.008
CitationsScopus - 41Web of Science - 38
Co-authorsJennifer Schneider
2004Ramasamy S, Isbister GK, Seymour JE, Hodgson WC, 'The in vivo cardiovascular effects of box jellyfish Chironex fleckeri venom in rats: efficiacy of pre-treatment with antivenom, verapamil and magnesium sulphate', Toxicon, 34 685-690 (2004) [C1]
DOI10.1016/j.toxicon.2004.02.024
CitationsScopus - 43Web of Science - 40
2004Isbister GK, Whaite J, 'Clinical consequences of spider bites: recent advances in our understanding', Toxicon, 43 477-492 (2004) [C1]
DOI10.1016/j.toxicon.2004.02.002
CitationsScopus - 43Web of Science - 36
2004Isbister GK, Gray MR, 'Bites by Australian mygalomorph spiders (Araneae, Mygalomorphae), including funnel-web spiders (Atracinae) and mouse spiders (Actinopodidae: Missulena spp)', Toxicon, 43 133-140 (2004) [C1]
DOI10.1016/j.toxicon.2003.11.009
CitationsScopus - 12Web of Science - 8
2004Ramasamy S, Isbister GK, Hodgson WC, 'The Efficacy of Two Antivenoms against the in Vitro Myotoxic effects of Black Snake (Pseudechis) Venoms in the Chick Biventer Cervicis Nerve-Muscle Preparation', Toxicon, 44 837-845 (2004) [C1]
DOI10.1016/j.toxicon.2004.08.005
CitationsScopus - 16Web of Science - 16
2004Isbister GK, Downes F, Sibbritt DW, Dawson AH, Whyte IM, 'Aspiration pneumonitis in an overdose population: Frequency, predictors and outcomes', Critical Care Medicine, 32 88-93 (2004) [C1]
DOI10.1097/01.CCM.0000104207.42729.E4
CitationsScopus - 44Web of Science - 32
2004Isbister GK, 'Necrotic arachnidism: the mythology of a modern plague', The Lancet, 364 549-553 (2004) [C3]
CitationsScopus - 32Web of Science - 20
2004Vetter RS, Isbister GK, 'Do hobo spider bites cause dermonecrotic injuries?', ANNALS OF EMERGENCY MEDICINE, 44 605-607 (2004)
DOI10.1016/j.annemergmed.2004.03.016Author URL
CitationsScopus - 21Web of Science - 16
2004Isbister GK, O'Regan L, Sibbritt DW, Whyte IM, 'Alprazolam is relatively more toxic than other benzodiazepines in overdose', British Journal of Clinical Pharmacology, 58 88-95 (2004) [C1]
DOI10.1111/j.1365-2125.2004.02089.x
CitationsScopus - 35Web of Science - 24
2004Balit CR, Harvey MS, Waldock JM, Isbister GK, 'Prospective Study of Centipede Bites in Australia', Clinical Toxicology, 42 41-48 (2004) [C1]
DOI10.1081/CLT-120028743
CitationsScopus - 25Web of Science - 16
2004Isbister GK, Framenau VW, 'Australian Wolf Spider Bites (Lycosidae): Clinical Effects and Influence of Species on Bite Circumstances', Clinical Toxicology, 42 153-161 (2004) [C1]
DOI10.1081/CLT-120030941
CitationsScopus - 12Web of Science - 10
2004Isbister GK, Dawson AH, Whyte IM, 'Arsenic trioxide poisoning: a description of two acute overdoses', Human & Experimental Toxicology, 23 359-364 (2004) [C3]
CitationsScopus - 8Web of Science - 9
2004Isbister GK, 'Prospective cohort study of definite spider bites in Australian children', Journal of Pediatrics and Child Health, 40 360-364 (2004) [C1]
DOI10.1111/j.1440-1754.2004.00402.x
CitationsScopus - 4Web of Science - 2
2004Isbister GK, Whyte IM, 'Suspected white-tail spider bite and necrotic ulcers', Internal Medicine Journal, 34 38-44 (2004) [C1]
DOI10.1111/j.1444-0903.2004.00506.x
CitationsScopus - 24Web of Science - 20
2004Isbister GK, Volschenk ES, Seymour JE, 'Scorpion stings in Australia: five definite stings and a review', Internal Medicine Journal, 34 427-430 (2004) [C1]
DOI10.1111/j.1445-5994.2004.00625.x
CitationsScopus - 8Web of Science - 6
2004Isbister GK, Gray MR, 'Black house spiders are unlikely culprits in necrotic arachnidism: a prospective study', Internal Medicine Journal, 34 287-289 (2004) [C1]
DOI10.1111/j.1444-0903.2004.00562.x
CitationsScopus - 12Web of Science - 11
2004Isbister GK, Bowe SJ, Dawson AH, Whyte IM, 'Relative Toxicity of Selective Serotonin Reuptake Inhibitors (SSRIs) in Overdose', Clinical Toxicology, 42 277-285 (2004) [C1]
DOI10.1081/CLT-120037428
CitationsScopus - 205Web of Science - 147
2004Isbister GK, Sibbritt DW, 'Developing a decision tree algorithm for the diagnosis of suspected spider bites', Emergency Medicine Australasia, 16 161-166 (2004) [C1]
CitationsScopus - 3
2004Balit CR, Geary MJ, Russell RC, Isbister GK, 'Clinical effects of exposure to the White-stemmed gum moth (Chelepteryx collesi)', Emergency Medicine Australasia, 16 74-81 (2004) [C1]
CitationsScopus - 11
2004Isbister GK, Adams J, 'Investigating the relationships between emergency departments and complementary and alternative medicine use in Australia', Emergency Medicine Australasia, 16 378-381 (2004) [C3]
2003Little M, Murray L, Armstrong J, Dawson AH, Whyte IM, Isbister GK, et al., 'Clinical toxicology; 'bones' of contention', Critical Care and Resuscitation, 5 71-73 (2003) [C3]
2003Sibbritt DW, Dawson AH, Whyte IM, Dunkley EJC, Isbister GK, 'The Hunter Serotonin Toxicity Criteria: simple and accurate diagnostic decision rules for serotonin toxicity', Q J Medicine: an international journal of medicine, 96 635-642 (2003) [C1]
DOI10.1093/qjmed/hcg109
CitationsScopus - 307Web of Science - 208
2003Isbister GK, Dawson AH, Whyte IM, 'Feasibility of prehospital treatment with activated charcoal: Who could we treat, who should we treat?', Emergency Medicine Journal, 375-378 (2003) [C1]
DOI10.1136/emj.20.4.375
CitationsScopus - 13Web of Science - 8
2003Isbister GK, Oakley P, Dawson AH, Whyte IM, 'Presumed Angel's trumpet (Brugmansia) poisoning: Clinical effects and epidemiology', Emergency Medicine Journal, 376-382 (2003) [C1]
DOI10.1046/j.1442-2026.2003.00477.x
CitationsScopus - 9
2003Isbister GK, Currie BJ, 'Suspected snakebite: One year prospective study of emergency department presentations', Emergency Medicine (Carleton South), 15 160-169 (2003) [C1]
DOI10.1046/j.1442-2026.2003.00434.x
CitationsScopus - 19
2003Caldicott D, Isbister J, Das R, Isbister GK, 'Medical activism, refugees, and Australia (The land of the 'fair go')', Emergency Medicine (Carleton South), 15 176-182 (2003) [C1]
DOI10.1046/j.1442-2026.2003.00353.x
CitationsScopus - 1
2003Isbister GK, 'Acute conjunctival inflammation following contact with squashed spider contents', American Journal of Opthalmology, 136 563-564 (2003) [C3]
CitationsScopus - 6Web of Science - 6
2003Isbister GK, 'Latrodectism: a prospective cohort study of bites by formally identified redback spiders - Reply', MEDICAL JOURNAL OF AUSTRALIA, 179 455-456 (2003)
Author URL
CitationsScopus - 4
2003Balit CR, Isbister GK, Dawson AH, Daly FF, Whyte IM, 'The effect of recalling paracetamol on hospital admissions for poisoning', Medical Journal of Australia, 179 221 (2003) [C3]
2003Balit CR, Lynch CN, Isbister GK, 'Bupropion poisoning: A case series', Medical Journal of Australia, 178 61-63 (2003) [C1]
CitationsScopus - 40Web of Science - 33
2003Isbister GK, Gray MR, 'Latrodectism: a prospective cohort study of bites by formally identified redback spiders', Medical Journal of Australia, 179 88-91 (2003) [C1]
CitationsScopus - 38Web of Science - 30
2003Isbister GK, Gray MR, 'White-tail spider bite: a prospective study of 130 definite bites by Lampona species', Medical Journal of Australia, 179 199-202 (2003) [C1]
CitationsScopus - 43Web of Science - 30
2003Isbister GK, McGettigan P, Harris I, 'Hyperbaric oxygen for acute carbon monoxide poisoning', NEW ENGLAND JOURNAL OF MEDICINE, 348 558-558 (2003)
Author URL
CitationsScopus - 22Web of Science - 2
2003Isbister GK, McGettigan PG, Harris I, 'Hyperbaric Oxygen for Acute Carbon Monoxide Poisoning', New England Journal of Medicine, 348 557-560 (2003) [C3]
CitationsScopus - 9
2003McGettigan PG, Isbister GK, Whyte IM, 'Adolescent Depression', New England Journal of Medicine, 348 473 (2003) [C3]
2003Isbister GK, Hirst D, 'A prospective study of definite bites by spiders of the family Sparassidae (huntsmen spiders) with identification to species level', Toxicon, 163-171 (2003) [C1]
DOI10.1016/S0041-0101(03)00129-6
CitationsScopus - 9Web of Science - 7
2003Isbister GK, Volschenk ES, Balit CR, Harvey MS, 'Australian scorpion stings: a prospective study of definite stings', Toxicon, 877-883 (2003) [C1]
DOI10.1016/S0041-0101(03)00065-5
CitationsScopus - 19Web of Science - 15
2003Isbister GK, Seymour JE, Gray MR, Raven RJ, 'Bites by spiders of the family Theraphosidae in humans and canines', Toxicon, 519-524 (2003) [C1]
DOI10.1016/S0041-0101(02)00395-1
CitationsScopus - 29Web of Science - 25
2003Ramasamy S, Isbister GK, Seymour JE, Hodgson WC, 'The in vitro effects of two chirodropid (Chironex fleckeri and Chiropsalmus sp.) venoms: efficacy of box jellyfish antivenom', Toxicon, 703-711 (2003) [C1]
DOI10.1016/S0041-0101(03)00046-1
CitationsScopus - 21Web of Science - 16
2003Balit CR, Geary MJ, Russell RC, Isbister GK, 'Prospective study of definite caterpillar exposures', Toxicon: an interdisciplinary journal on the toxins derived from animals, plants and microorganisms, 42 657-662 (2003) [C1]
DOI10.1016/j.toxicon.2003.09.003
CitationsScopus - 12Web of Science - 9
2003Isbister GK, Hackett LP, Whyte IM, 'Intentional Warfarin Overdose', Therapeutic Drug Monitoring, 25 715-722 (2003) [C1]
DOI10.1097/00007691-200312000-00010
CitationsScopus - 6Web of Science - 5
2003Balit CR, Isbister GK, Hackett L, Whyte IM, 'Quetiapine Poinsoning : A case series', Annals o f emergency Medicine, 42 751-758 (2003) [C1]
DOI10.1016/S0196-0644(03)00600-0
CitationsScopus - 70Web of Science - 54
2003Isbister GK, Downes F, Whyte IM, 'Regular medication and paracetamol overdose', Alimentary Pharmacology and Therapeutics, 17 609-610 (2003) [C3]
2003Isbister GK, Balit CR, Whyte IM, Dawson AH, 'Valproate overdose: a comparative cohort study of self poisonings', British Journal of Clinical Pharmacology, 398-404 (2003) [C1]
DOI10.1046/j.1365-2125.2003.01772.x
CitationsScopus - 28Web of Science - 18
2003Isbister GK, Hackett LP, Dawson AH, Whyte IM, Smith AJ, 'Moclobemide poisoning: toxicokinetics and occurrence of serotonin toxicity', British Journal of Clinical Pharmacology, 441-450 (2003) [C1]
DOI10.1046/j.1365-2125.2003.01895.x
CitationsScopus - 44Web of Science - 29
2003Isbister GK, Whyte IM, Downes F, Dawson AH, McGettigan PG, 'Concomitant overdosing of other drugs in patients with paracetamol poisoning', British Journal of Clinical Pharmacology, 55 326 (2003) [C3]
CitationsScopus - 1
2003Isbister GK, Warner G, 'Acute myocardial injury caused by Sydney funnel-web spider (atrax robustus) envenoming', Anaesthesia and Intensive Care, 31 672-674 (2003) [C1]
CitationsScopus - 2Web of Science - 1
2003Jaiswal S, Coombs RC, Isbister GK, 'Paroxetine withdrawal in a neonate with historical and aboratory confirmation', European Journal of Pediatrics, 162 723-724 (2003) [C3]
CitationsScopus - 20Web of Science - 17
2003Isbister GK, Whyte IM, 'Adverse reactions to Mirtazapine are unlikely to be serotonin toxicity', Clinical Neuropharmacology, 26 287-288 (2003) [C3]
CitationsScopus - 9Web of Science - 7
2003Isbister GK, Gray MR, 'Effects of envenoming by comb-footed spiders of the genera steatoda and achaearanea (family theridiidae: araneae) in Australia', Journal of Toxicology. Clinical Toxicology, 41 809-819 (2003) [C1]
DOI10.1081/CLT-120025346
CitationsScopus - 22Web of Science - 18
2003Smith AJ, Isbister GK, 'Antivenoms: Editorial Commentary', Journal of Toxicology, 41 261-262 (2003) [C3]
CitationsScopus - 3Web of Science - 2
2003Isbister GK, Graudins A, White J, Warrell D, 'Antivenom Treatment in Arachnidism', Journal of Toxicology, Clinical Toxicology, 41 291-300 (2003) [C1]
DOI10.1081/CLT-120021114
CitationsScopus - 74Web of Science - 60
2003Isbister GK, Hackett LP, 'Nefazodone Poisoning: Toxicokinetics and Toxicodynamics Using Continuous Data Collection', Journal of Toxicology, Clinical Toxicology, 41 167-173 (2003) [C3]
CitationsScopus - 8Web of Science - 5
2003White J, Warrell D, Eddleston M, Currie BJ, Whyte IM, Isbister GK, 'Clinical Toxinology - Where Are We Now?', Journal of Toxicology, Clinical Toxicology, 41 263-267 (2003) [C1]
DOI10.1081/CLT-120021112
CitationsScopus - 41Web of Science - 35
2003Balit CR, Isbister GK, Buckley NA, 'Randomized controlled trial of topical aspirin in the treatment of bee and wasp stings', Journal of Toxicology. Clinical Toxicology, 41 801-808 (2003) [C1]
DOI10.1081/CLT-120025345
CitationsScopus - 6Web of Science - 2
2003Isbister GK, 'Comment: combination risperidone and SSRI-induced serotonin syndrome', ANNALS OF PHARMACOTHERAPY, 37 1531-1532 (2003)
DOI10.1345/aph.1C228aAuthor URL
CitationsScopus - 5Web of Science - 2
2003Isbister GK, Balit CR, 'Bupropion Overdose: QTc Prolongation and Its Clinical Significance', The Annals of Pharmacotherapy, 999-1002 (2003) [C1]
DOI10.1345/aph.1C481
CitationsScopus - 34Web of Science - 28
2003Isbister GK, Downes F, Whyte IM, 'Olanzapine and serotonin toxicity', Psychiatry and Clinical Neurosciences, 57 241-242 (2003) [C3]
CitationsScopus - 10Web of Science - 8
2002Balit CR, Isbister GK, Dawson AH, Whyte IM, 'Paracetamol recall: a natural experiment influencing analgesic poisoning - Reply', MEDICAL JOURNAL OF AUSTRALIA, 176 562-563 (2002)
Author URL
2002Isbister GK, Son J, Wang F, Maclean C, Lin C, Ujma J, et al., 'Puffer fish poisoning: a potentially life-threatening condition', Medical Journal of Australia, 177 650-653 (2002) [C1]
CitationsScopus - 34Web of Science - 24
2002Prior F, Isbister GK, Dawson AH, Whyte IM, 'Serotonin toxicity with therapeutic doses of dexamphetamine and venlafaxine', Medical Journal of Australia, 176 240-241 (2002) [C3]
CitationsScopus - 12Web of Science - 10
2002Balit CR, Isbister GK, Peat J, Dawson AH, Whyte IM, 'Paracetamol recall: A natural experiment influencing analgesic poisoning', Medical Journal of Australia, 176 162-165 (2002) [C1]
CitationsScopus - 11Web of Science - 13
2002Isbister GK, Currie B, Little M, Daly F, 'Coagulopathy from tiger snake envenoming and its treatment', Pathology, 34 588-589 (2002) [C3]
CitationsScopus - 7Web of Science - 7
2002Isbister GK, Dawson AH, Whyte IM, 'Two cases of bites by the black-bellied swamp snake (Hemiaspis signata)', TOXICON, 40 317-319 (2002)
DOI10.1016/S0041-0101(01)00221-5Author URL
CitationsScopus - 4Web of Science - 3
2002Isbister GK, 'Acute allergic reaction following contact with a spider', Toxicon, 40 1495-1497 (2002) [C1]
CitationsScopus - 13Web of Science - 9
2002Eddleston M, Karalliedde L, Buckley N, Fernando R, Hutchinson G, Isbister GK, et al., 'Pesticide poisoning in the developing world - a minimum pesticides list', The Lancet, 360 1163-1167 (2002) [C1]
CitationsScopus - 199Web of Science - 165
2002Isbister G, Whyte IM, 'Atypical Presentation of Risperidone Toxicity', Veterinary and Human Toxicology, 44(2) 118-119 (2002) [C3]
CitationsScopus - 7Web of Science - 6
2002Isbister GK, Hirst D, 'Injuries from spider spines, not spider bites', Veterinary and Human Toxicology, 44(6) 339-342 (2002) [C1]
CitationsScopus - 9Web of Science - 8
2002Isbister G, 'Toxicology', Current Therapeutics, 43 (2002)
2002Isbister G, 'Toxicology', Current Therapeutics, 43 (2002)
2002Isbister G, 'Toxicology', Current Therapeutics, 43 (2002)
2002Isbister G, 'Toxicology', Current Therapeutics, 43 (2002)
2002Isbister G, 'Toxicology', Current Therapeutics, 43 (2002)
2002Isbister G, 'Rat poison', Current Therapeutics, 43 (2002)
2002Isbister G, 'Hydroxychloroquine poisoning', Current Therapeutics, 43 (2002)
2002Isbister GK, 'Data Collection in Clinical Toxinology: Debunking Myths and Developing Diagnostic Algorithms', Journal of Toxicology-Clinical Toxicology, 40(3) 231-237 (2002) [C1]
CitationsScopus - 43Web of Science - 40
2002Isbister G, Dawson AH, Whyte IM, 'Hydroxychloroquine Overdose: a Prospective case series', American Journal of Emergency Medicine, 20(4) 377-378 (2002) [C3]
CitationsScopus - 10Web of Science - 7
2002Caldicott D, Isbister GK, Edwards N, 'Publication and patriotism', ANZ JOURNAL OF SURGERY, 72 768-768 (2002)
DOI10.1046/j.1445-2197.2002.t01-1-02534.xAuthor URL
2002Isbister GK, Gray M, 'A prospective study of 750 definite spider bites, with expert spider identification', QJMedicine, 95 723-731 (2002) [C1]
CitationsScopus - 65Web of Science - 51
2002Isbister GK, 'Delayed asystolic cardiac arrest after diltiazem overdose; resuscitation with high dose intravenous calcium', Emergency Medicine Journal, 19 355-356 (2002) [C2]
CitationsScopus - 22Web of Science - 11
2002Isbister GK, Dawson A, Whyte IM, 'Comment: serotonin syndrome and 5-HT2a antagonism (vol 35, pg 1143, 2001)', ANNALS OF PHARMACOTHERAPY, 36 1484-1484 (2002)
Author URL
2002Isbister GK, Dawson AH, Whyte IM, 'Comment: neuroleptic malignant syndrome associated with risperidone and fluvoxamine', The Annals of Pharmacotherapy, 36 1293 (2002) [C3]
CitationsScopus - 3Web of Science - 1
2002Isbister GK, 'Failure of intramuscular antivenom in Red-back spider envenoming', Emergency Medicine, 14(4) 436-439 (2002) [C1]
CitationsScopus - 12
2002Isbister G, Whyte IM, 'Serotonin toxicity and malignant hyperthermia: role of 5-HT2 receptors', British Journal of Anaesthesia, 88(4) 603 (2002) [C3]
CitationsScopus - 13Web of Science - 11
2001Isbister G, Whyte IM, Smith AN, 'Olanzapine overdose', Anaesthesia, 56 400-401 (2001) [C3]
CitationsScopus - 6Web of Science - 5
2001Isbister G, Bucens I, Whyte IM, 'Paracetamol overdose in a preterm neonate', Archives of Disease in Childhood: Fetal & Neonatal Edition, 85 F70-F72 (2001) [C2]
CitationsScopus - 23Web of Science - 11
2001Isbister GK, Balit C, 'Eye exposure to squashed spiders', MEDICAL JOURNAL OF AUSTRALIA, 175 391-392 (2001)
Author URL
CitationsScopus - 4Web of Science - 4
2001Balit CR, Ptolemy HC, Geary MJ, Russell RC, Isbister GK, 'Outbreak of caterpillar dermatitis caused by airborne hairs of the mistletoe browntail moth (Euproctis edwardsi)', MEDICAL JOURNAL OF AUSTRALIA, 175 641-643 (2001)
Author URL
CitationsScopus - 20Web of Science - 15
2001Balit C, Ptolemy H, Geary MJ, Russell RC, Isbister GK, 'A caterpillar dermatitis outbreak following contact with the hairs of the Mistletoe Browntail moth (Euproctis edwardsi)', Med J Aust 2001; 175:641-3, 641-643 (2001) [C3]
2001Isbister GK, Hirst DB, Gray MR, Currie BJ, 'Clinical effects in bites from formally identified spiders in tropical Northern Territory', Medical Journal Australia, 174 79-82 (2001) [C1]
CitationsScopus - 15Web of Science - 15
2001O''Reilly GM, Isbister GK, Lawrie PM, Treston G, Currie BJ, 'Prospective study of jellyfish stings from tropical Australia, including the major box jellyfish Chironex fleckeri', Medical Journal Australia, 175 652-655 (2001) [C1]
CitationsScopus - 39Web of Science - 32
2001Isbister GK, 'Necrotic arachnidism in Australia', Toxicon. 2001 Dec;39(12):1941-2, 1941-1942 (2001) [C3]
CitationsWeb of Science - 7
2001Isbister G, 'Serotonin syndrome and 5-HT2a antagonism', Ann Pharm, 0 1143-1144 (2001) [C3]
2001Isbister GK, 'Serotonin syndrome, mydriasis, and cyproheptadine', Ann Pharmacother 2001 Dec ;35(12):1672, (2001) [C3]
2001Isbister GK, Dawson AH, Whyte IM, 'Serotonin syndrome induced by fluvoxamine and mirtazapine', Ann Pharmacother 2001 Dec ;35(12):1674, (2001) [C3]
2001Isbister GK, Little M, Seymour J, 'Jellyfish stings', Vet Hum Toxicol 2001, 43(6): 373, (2001) [C3]
CitationsWeb of Science - 1
2001Isbister GK, Whyte IM, 'Management of anticoagulant poisoning', Vet Hum Toxicol, 43(2):117, 2001 April, (2001) [C3]
CitationsWeb of Science - 1
2001Whyte IM, Isbister G, 'Misdiagnosis of Myoclonus in Antidepressant Induced Serotonin Excess', Veterinary and Human Toxicology, 43(6) 376 (2001) [C3]
CitationsScopus - 2Web of Science - 2
2001Isbister G, McGettigan PG, Dawson AH, 'A Fatal Case of Moclobemide-Citalopram Intoxication', Journal of Analytical Toxicology, 25 716-717 (2001) [C3]
CitationsScopus - 6Web of Science - 5
2001Isbister G, Oakley P, Whyte IM, Dawson AH, 'Treatment of Anticholinergic-Induced Ileus With Neostigmine', Annals of Emergency Medicine, 38(6) 689-693 (2001) [C2]
CitationsScopus - 6Web of Science - 2
2001Isbister GK, Dawson A, Whyte IM, 'Citalopram overdose, serotonin toxicity, or neuroleptic malignant syndrome?', Can J Psych 2001 Sep;46(7):657-9., 657-659 (2001) [C3]
CitationsScopus - 5Web of Science - 4
2001Isbister G, Whyte IM, Dawson AH, 'Pediatric Acetaminophen Overdose', Clinical Toxicology, 39(2) 169-170 (2001) [C3]
CitationsScopus - 4Web of Science - 1
2001Isbister GK, 'Venomous fish stings in tropical northern Australia', AMERICAN JOURNAL OF EMERGENCY MEDICINE, 19 561-565 (2001)
DOI10.1053/ajem.2001.28325Author URL
CitationsScopus - 32Web of Science - 23
2001Isbister GK, 'Venomous fish stings', Am J Emerg Med, 19 561-565 (2001) [C1]
2001Isbister GK, Balit C, 'Effects of legislation restricting pack sizes of paracetamol on self poisoning. Authors did not look at effects on all deliberate and accidental self poisoning', BMJ. 2001 Sep 15;323(7313):633-4, 633-634 (2001) [C3]
CitationsScopus - 2Web of Science - 2
2001Dargan P, Jones A, Isbister G, Balit C, Andrus JP, Herzenberg LA, et al., 'Effects of legislation restricting pack sizes of paracetamol on self poisoning [8] (multiple letters)', British Medical Journal, 323 633-634 (2001)
CitationsScopus - 2
2001Isbister G, Dawson AH, Isbister J, 'Recommendations for the management of over-anticoagulation with warfarin', Emergency Medicine, 13 469-472 (2001) [C2]
CitationsScopus - 4
2001Isbister GK, 'Comment: serotonin syndrome, mydriasis, and cyproheptadine', ANNALS OF PHARMACOTHERAPY, 35 1672-1673 (2001)
Author URL
CitationsScopus - 7Web of Science - 7
2001Isbister GK, Prior F, Foy A, 'Citalopram-Induced Bradycardia and Presyncope', Ann Pharm 2001 Dec 35(12): 1552-5, 1552-1555 (2001) [C3]
CitationsScopus - 17Web of Science - 12
2001Isbister G, Dawson AH, Whyte IM, 'Comment: serotonin syndrome and 5-HT2a antagonism', The Annals of Pharmacotherapy, 35(9) 1143-1144 (2001) [C3]
CitationsScopus - 6Web of Science - 7
2001Isbister G, Dawson AH, Whyte IM, 'Comment: serotonin syndrome induced by fluvoxamine and mirtazapine', The Annals of Pharmacotherapy, 35 1674-1675 (2001) [C3]
CitationsScopus - 11Web of Science - 8
2001Isbister G, Whyte I, Dawson A, 'Pediatric acetaminophen poisoning', ARCHIVES OF PEDIATRICS & ADOLESCENT MEDICINE, 155 417-418 (2001)
Author URL
CitationsScopus - 9Web of Science - 3
2001Isbister G, Dawson AH, Whyte IM, Prior F, Clancy C, Smith AN, 'Neonatal paroxetine withdrawal syndrome or actually serotinin syndrome?', Archives of Disease in Childhood: Fetal & Neonatal Edition, 85(2) 147-148 (2001) [C3]
CitationsScopus - 41Web of Science - 29
2001Isbister GK, Whyte IM, Dawson A, 'The Pediatric Forum: Pediatric Acetaminophen Poisoning', Arch Pediatr Adolesc Med. 2001 Mar;155(3):417-9, 417-419 (2001) [C3]
2001Isbister GK, 'Spider mythology across the world', West J Med. 2001 Aug;175(2):86-7, 86-87 (2001) [C3]
CitationsScopus - 16Web of Science - 16
2000Isbister G, Gray M, 'Acute and recurrent skin ulceration after spider bite', MEDICAL JOURNAL OF AUSTRALIA, 172 303-304 (2000)
Author URL
CitationsWeb of Science - 7
2000Isbister GK, Whelan PI, 'Envenomation by the billygoat plum stinging caterpillar (Thosea penthima)', MEDICAL JOURNAL OF AUSTRALIA, 173 654-655 (2000)
Author URL
CitationsScopus - 8Web of Science - 5
2000Isbister G, Gray M, Winkel KD, 'Acute and recurrent skin ulceration after spider bite [7] (multiple letters)', Medical Journal of Australia, 172 303-304 (2000)
CitationsScopus - 6
2000Isbister GK, 'Failure of intravenous calcium gluconate for hydrofluoric acid burns', ANNALS OF EMERGENCY MEDICINE, 36 398-399 (2000)
DOI10.1067/mem.2000.110019Author URL
CitationsScopus - 1Web of Science - 1
2000Isbister GK, Smart DR, 'Spider bites in Australia (multiple letters)', Emergency Medicine, 12 72-73 (2000)
DOI10.1046/j.1442-2026.2000.00099.x
Show 366 more journal articles

Review (2 outputs)

YearCitationAltmetricsLink
2014Marcus EN, Isbister GK, 'Jellyfish stings (2014) [D1]
2014Isbister GK, 'Marine envenomations from corals, sea urchins, fish, or stingrays (2014) [D1]

Conference (62 outputs)

YearCitationAltmetricsLink
2015Isbister G, Maduwage K, Saiao A, Buckley N, Jayamanne S, Seyed S, et al., 'Population pharmacokinetics of an Indian F(ab¿)2 snake antivenom in patients with Russell¿s viper bite', Clinical Toxicology, St. Julian's, Malta (2015)
2015Isbister G, Maduwage K, Saiao A, Buckley N, Jayamanne S, Seyed S, et al., 'Population pharmacokinetics of an Indian F(ab')2 snake antivenom in patients with Russell's viper bite', Clinical Toxicology, St. Julian's, Malta (2015)
2014Ryan NM, Isbister GK, 'Tramadol overdose is associated with an increased risk of seizure and unassociated with serotonin toxicity', TAPNA Conference Program, Newcastle, NSW (2014) [E3]
Co-authorsNicole Ryan
2014Cooper J, Duffull SB, Saiao AS, Isbister GK, 'The effect of single-dose activated charcoal following sertraline overdose', The 40th SHPA National Conference: Book of Abstracts, Darwin (2014) [E3]
Co-authorsJoyce Cooper
2014Drinkwater V, Calver L, Bjorksten C, Isbister G, Gupta R, 'HOW AN INTERFACE BETWEEN ACUTE PSYCHIATRIC SERVICES AND AN EMERGENCY DEPARTMENT HAS IMPROVED THE MANAGEMENT OF ACUTE BEHAVIOURAL DISTURBANCE', AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY (2014) [E3]
Author URL
2014Scott A, Brown A, Dunlop A, Gill T, Holland R, Fisk C, et al., 'QT PROLONGATION IN OPIOID SUBSTITUTION THERAPY: ANALYSIS OF CONTINUOUS 12-LEAD ELECTROCARDIOGRAM RECORDINGS', DRUG AND ALCOHOL REVIEW (2014) [E3]
Author URL
2014Maduwage K, Scorgie F, Fahim M, Karunathilake H, Abeyasinghe C, O'Leary MA, et al., 'Measurement of venom and clotting function in patients with Russell's viper coagulopathy and response to antivenom', CLINICAL TOXICOLOGY (2014) [E3]
Author URL
2014Isbister GK, Buckley NA, Brown SGA, 'The knowledge of receiving antivenom is more effective than antivenom or analgesia for treating latrodectism', CLINICAL TOXICOLOGY (2014) [E3]
Author URL
2014Page CB, Berling I, Isbister GK, 'Rate dependent bundle branch block in drug overdose: A case report', CLINICAL TOXICOLOGY (2014) [E3]
Author URL
2014Downes MA, Muscat TM, Ritchie N, Isbister GK, 'Impact of an emergency short stay unit on emergency department performance with toxicology patients', CLINICAL TOXICOLOGY (2014) [E3]
Author URL
2014Berling I, Isbister GK, 'Antipsychotic overdose QT nomogram risk assessment', CLINICAL TOXICOLOGY (2014) [E3]
Author URL
2014Maduwage K, Scorgie F, Fahim M, Karunathilake H, Abeyasinghe C, O'Leary MA, et al., 'Measurement of venom and clotting function in patients with Russell's viper coagulopathy and response to antivenom', CLINICAL TOXICOLOGY (2014) [E3]
Author URL
2014Maduwage K, Scorgie F, Fahim M, Karunathilake H, Abeyasinghe C, O'Leary MA, et al., 'Measurement of venom and clotting function in patients with Russell's viper coagulopathy and response to antivenom', CLINICAL TOXICOLOGY (2014) [E3]
Author URL
2014Isbister GK, Buckley NA, Brown SGA, 'The knowledge of receiving antivenom is more effective than antivenom or analgesia for treating latrodectism', CLINICAL TOXICOLOGY (2014) [E3]
Author URL
2014Ryan NM, Brown SSGA, Isbister GK, 'Serum sickness after the administration of Australian snake antivenoms', CLINICAL TOXICOLOGY (2014) [E3]
Author URL
Co-authorsNicole Ryan
2014Page CB, Berling I, Isbister GK, 'Rate dependent bundle branch block in drug overdose: A case report', CLINICAL TOXICOLOGY (2014) [E3]
Author URL
2014Maduwage KP, O'Leary MA, Isbister GK, 'Diagnosis of snake envenomation using a simple phospholipase A2 assay', CLINICAL TOXICOLOGY (2014) [E3]
Author URL
2014Ryan NM, Brown SSGA, Isbister GK, 'Serum sickness after the administration of Australian snake antivenoms', CLINICAL TOXICOLOGY (2014) [E3]
Author URL
2013Brown SGA, Stone SF, Fatovich DM, Burrows SA, Holdgate A, Celenza A, et al., 'Anaphylaxis: clinical features and evidence for a mast cell-leukocyte cytokine cascade in humans', ALLERGY, Milan, ITALY (2013) [E3]
Author URL
2012Lincz L, Johnston CI, Scorgie FE, O'Leary MA, Prasad R, Seldon MR, et al., 'Comparative sensitivity of different commercially available aPTT reagents to a clinically relevant 'coagulation inhibitor'', HAA 2012: 2012 Co-Joint Scientific Meeting. ASTH Posters, Melbourne (2012) [E3]
Co-authorsLisa Lincz
2012Noutsos T, Currie B, Brown SGA, Isbister GK, 'Thrombotic microangiopathy due to snake envenomation: A large case series', HAA 2012: 2012 Co-Joint Scientific Meeting. ASTH Posters, Melbourne (2012) [E3]
2012Scorgie FE, Maduwage KP, Lincz L, Shahmy S, Mohamed F, Seldon MR, Isbister GK, 'Comparison of the haemostatic effects of three different procoagulant snake venoms in human envenoming', HAA 2012: 2012 Co-Joint Scientific Meeting. ASTH Posters, Melbourne (2012) [E3]
Co-authorsLisa Lincz
2012Johnston CI, O'Leary MA, Brown SGA, Currie BJ, Isbister GK, 'Death Adder envenoming causes neurotoxicity not reversed by antivenom - Australian Snakebite Project (ASP-16)', Toxicon, Honolulu, Hawaii (2012) [E3]
2012Brinkman DL, Mulvenna J, Konstantakopoulos N, Hodgson WC, Isbister GK, Seymour JE, Burnell JN, 'Molecular diversity of Box Jellyfish toxins', Toxicon, Honolulu, Hawaii (2012) [E3]
CitationsWeb of Science - 1
2012Calver L, Page BC, Downes M, Chan B, Isbister GK, 'Safety of droperidol for sedation and acute behavioural disturbance', Academic Emergency Medicine, Chicago (2012) [E3]
2012Calver L, Page BC, Downes M, Chan B, Isbister GK, 'Droperidol for sedation of acute behavioural disturbance', Academic Emergency Medicine, Chicago (2012) [E3]
2012Allen G, O'Leary MA, Brown SGA, Buckley NA, Isbister GK, 'Clinical effects and antivenom dosing in Brown Snake (Pseudonaja spp.) Envenoming - Australian Snakebite Project (ASP-14)', Clinical Toxicology, London, UK (2012) [E3]
CitationsScopus - 14
2012Saiao A, Chan B, Isbister GK, 'Pharmacokinetics and outcomes in massive paracetamol overdose', Clinical Toxicology, London, UK (2012) [E3]
CitationsWeb of Science - 1
2012Isbister GK, Brown SGA, 'Bites in Australian snake handlers - Australian Snakebite Project (ASP-15)', Clinical Toxicology, London, UK (2012) [E3]
2012Berling I, Whyte IM, Isbister GK, 'Oxycodone overdose: A case series', Clinical Toxicology, London, UK (2012) [E3]
2012Johnston CI, O'Leary MA, Brown SGA, Currie BJ, Greenberg R, Taylor M, et al., 'Mulga snake (Pseudechis australis) envenoming: A spectrum of myotoxicity, anticoagulant coagulopathy, haemolysis and the role of early antivenom therapy - Australian Snakebite Project (ASP-18)', ASCEPT-APSA Oral Abstracts, Sydney, NSW (2012) [E3]
2011Calver L, Downes MA, Isbister GK, 'Assessment of QT prolongation in high-dose droperidol administration using continuous 12-lead holter recording', Clinical Toxicology, Dubrovnik, Croatia (2011) [E3]
2011Downes MA, Calver L, Isbister GK, 'Intralipid treatment of sedative hypnotic drug overdose: A case series', Clinical Toxicology, Dubrovnik, Croatia (2011) [E3]
CitationsWeb of Science - 1
2011Isbister GK, Shahmy S, Makarim MFM, Fahim M, Abeysinghe C, Karunatilake H, Ariaratnam CA, 'A randomised controlled trial of two infusion rates to decrease reactions to antivenom', Clinical Toxicology, Dubrovnik, Croatia (2011) [E3]
2011Isbister GK, White J, Currie BJ, Brown SGA, 'Clinical effects and treatment of envenoming by hoplocephalus spp. snakes in Australia', Clinical Toxicology, Dubrovnik, Croatia (2011) [E3]
DOI10.1016/j.toxicon.2011.09.013
2011Van Gorp F, Duffull SB, Hackett LP, Isbister GK, 'Population pharmacokinetics and pharmacodynamics of escitalopram in overdose and the effect of activated charcoal', Clinical Toxicology, Dubrovnik, Croatia (2011) [E3]
2010Isbister GK, Calver LA, Page CB, Stoke B, Bryant JL, Downes MA, 'Randomised Comparison Study of Intramuscular Droperidol Versus Midazolam for Violence and Acute Behavioural Disturbance in the Emergency Department - the DORM Study', CLINICAL TOXICOLOGY (2010) [E3]
Author URL
2010Isbister GK, Churchman A, O'Leary MA, Brown SGA, Brown CB, 'Clinical effects of red-bellied black snake (Pseudechis porphyriacus) envenoming and correlation with venom concentrations', Clinical Toxicology, Bordeaux, France (2010) [E3]
2010Isbister GK, Coulter C, Kleintjes F, Kwan WF, Lu B, McInnes S, Duffull SB, 'Developing a new administration regimen for N-acetylcysteine in paracetamol overdose using pharmacokinetic simulations', Clinical Toxicology, Bordeaux, France (2010) [E2]
2010Isbister GK, Calver L, Page CB, Stokes BJ, Bryant J, Downes MA, 'Randomised comparison study of intramuscular droperidol versus midazolam for violence and acute behavioural disturbance in the emergency department - the DORM Study', Clinical Toxicology, Bordeaux, France (2010) [E3]
Co-authorsBarrie Stokes
2010Isbister GK, 'Snake bites in Sri Lanka', 2010 North American Congress on Clinical Toxicology (NACCT) Meeting, Denver, CO (2010) [E3]
2010Isbister GK, 'The Australian Snakebite Project', AACB AIMS Combined Scientific Meeting 2010, Perth, WA (2010) [E3]
2010Isbister GK, 'Snake bites and coagulopathy', Australian and New Zealand Children's Haematology and Oncology Group Annual Scientific Meeting 2010. Program, Sydney, NSW (2010) [E3]
2010Isbister GK, 'Developing a rational approach to antivenom therapy', Australasian Society of Clinical and Experimental Pharmacology and Toxicology (ASCEPT) Annual Scientific Meeting, Melbourne, Vic (2010) [E3]
2010Calver L, Downes MA, Page CB, Bryant J, Isbister GK, 'Randomised controlled trial of intramuscular droperidol versus midazolam for acute behavioural disturbance - The DORM study', International Journal of Mental Health Nursing, Hobart, Tas (2010) [E3]
DOI10.1016/j.annemergmed.2010.05.037
CitationsScopus - 19
2010Isbister GK, 'Pathophysiology of serotonin toxicity: A tale of rodents, receptors and remedies', International Journal of Neuropsychopharmacology, Hong Kong (2010) [E3]
2009Lincz L, Woods D, Alley S, O'Leary MA, Seldon MR, Isbister GK, 'Endogenous thrombin potential as a novel method for characterisation of procoagulant snake venoms', Journal of Thrombosis and Haemostasis, Boston, MA (2009) [E3]
DOI10.1111/j.1538-7836.2009.03473_2.x
Co-authorsLisa Lincz
2009Downes MA, Healy P, Page CB, Bryant JL, Isbister GK, 'Code black: A structured approach to the agitated patient in the emergency department', Clinical Toxicology, Stockholm, Sweden (2009) [E3]
2009Isbister GK, 'Marine toxinology: Antivenom in hot water and other treatment controversies', Clinical Toxicology, Stockholm, Sweden (2009) [E3]
2009Isbister GK, Balit CR, Macleod D, Joy JP, Duffull SB, 'Amisulpride overdose causes QT prolongation and torsade de pointes: A national study', Clinical Toxicology, Stockholm, Sweden (2009) [E3]
CitationsWeb of Science - 2
2009Isbister GK, Scorgie F, Brown SGA, O'Leary MA, Seldon MR, Lincz L, 'Coagulation factor deficiencies associated with venom induced consumption coagulopathy in Australian snake envenoming', Clinical Toxicology, Stockholm, Sweden (2009) [E3]
CitationsWeb of Science - 4
Co-authorsLisa Lincz
2009Page CB, Calver LA, Isbister GK, 'Risperidone overdose: Much to do about nothing', Clinical Toxicology, Stockholm, Sweden (2009) [E3]
2009Kumar VVP, Oscarsson S, Friberg LE, Isbister GK, Hackett LP, Duffull SB, 'The Effect of Decontamination Procedures on the Pharmacokinetics of Venlafaxine in Overdose', THERAPEUTIC DRUG MONITORING, Montreal, CANADA (2009) [E3]
Author URL
2009Van Gorp F, Duffull SB, Hackett LP, Isbister GK, 'Population pharmacokinetics of escitalopram in overdose and the effect of charcoal', Therapeutic Drug Monitoring, Montreal, Canada (2009) [E3]
DOI10.1111/j.1365-2125.2011.04091.x
2009Kumar VVP, Oscarsson S, Friberg LE, Isbister GK, Hackett LP, Duffull SB, 'The effect of decontamination procedures on the pharmacokinetics of venlafaxine in overdose', Therapeutic Drug Monitoring, Montreal, Canada (2009) [E3]
DOI10.1038/clpt.2009.114
CitationsScopus - 13Web of Science - 10
2008Isbister GK, 'Is venlafaxine cardiotoxic in overdose? Evaluation of a case series using a QT nomogram', CLINICAL TOXICOLOGY (2008) [E3]
Author URL
2008Isbister GK, Brown SGA, Duffull S, 'Failure of antivenom for venom induced consumption coagulopathy in Australian snakebite', CLINICAL TOXICOLOGY (2008) [E3]
Author URL
2008Isbister GK, Duffull SB, 'Predicting intubation, duration of ventilation and cardiac monitoring in quetiapine overdose and the effect of activated charcoal', CLINICAL TOXICOLOGY (2008) [E3]
Author URL
2008Page CB, Isbister GK, Whyte IM, 'Delirium from Promethazine poisoning: A case series', Clinical Toxicology, Seville, Spain (2008) [E3]
DOI10.1080/15563650802071703
2008Isbister G, 'The role of coagulation testing in snake envenoming', INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY (2008) [E3]
Author URL
2008Enjeti A, Scorgie FE, Lincz L, Brown S, Isbister GK, Seldon MR, 'Circulating microparticles in snake bite patients with microangiopathy', 50th ASH Annual Meeting and Exposition. Online Program and Abstracts, San Francisco, CA (2008) [E3]
Co-authorsLisa Lincz
2008Lincz L, Woods D, Alley S, O'Leary MA, Seldon MR, Isbister GK, 'Endogenous thrombin potential (ETP) as a novel method for characterization of procoagulant snake venoms', HAA 2008 HSANZ ANZSBT ASTH: 2008 Annual Scientific Meeting: Abstracts, Perth, WA (2008) [E3]
Co-authorsLisa Lincz
Show 59 more conferences
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Grants and Funding

Summary

Number of grants25
Total funding$7,089,833

Click on a grant title below to expand the full details for that specific grant.


20143 grants / $1,961,766

An integrated research program in human toxicology to ensure rapid translation of results into practice and regulation$1,202,251

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Nicholas Buckley, Doctor Geoff Isbister, Professor Andrew Dawson, Professor Michael Roberts
SchemeProgram Grant
RoleLead
Funding Start2014
Funding Finish2014
GNoG1300141
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Improving Health Outcomes in Drug Overdose and Envenoming$739,515

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamDoctor Geoff Isbister
SchemeResearch Fellowships
RoleLead
Funding Start2014
Funding Finish2014
GNoG1300082
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Neuromuscular junction toxicity after anticholinesterase pesticide poisoning and envenomation$20,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Nicholas Buckley, Doctor Geoff Isbister, Professor Michael Roberts
SchemeProject Grant
RoleLead
Funding Start2014
Funding Finish2014
GNoG1500439
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

20123 grants / $230,721

A novel approach to snakebite first aid$195,721

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Dirk Van Helden, Doctor Geoff Isbister
SchemeProject Grant
RoleInvestigator
Funding Start2012
Funding Finish2012
GNoG1100333
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

First Aid for Cytotoxic Snakebite$25,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamProfessor Dirk Van Helden, Doctor Geoff Isbister
SchemeProject Grant
RoleInvestigator
Funding Start2012
Funding Finish2012
GNoG1200154
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Biomarkers of acute renal toxicity in humans$10,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Nicholas Buckley, Professor Zoltan Endre, Professor Andrew Dawson, Professor Rezvi Sheriff, Doctor Geoff Isbister, Professor Michael Roberts
SchemeProject Grant
RoleLead
Funding Start2012
Funding Finish2012
GNoG1100879
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

20112 grants / $1,490,286

Biomarkers of acute renal toxicity in humans$1,044,710

Multicentre observational study of poisoned and snake bite patients in Sri Lanka investigating renal toxicity and renal biomarkers.
Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project Team
SchemeProject Grant
RoleInvestigator
Funding Start2011
Funding Finish2013
GNo
Type Of FundingNot Known
CategoryUNKN
UONY

A randomised controlled trial of antivenom for red-bellied black snake envenoming$445,576

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamDoctor Geoff Isbister, Professor Nicholas Buckley
SchemeProject Grant
RoleLead
Funding Start2011
Funding Finish2011
GNoG1000301
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

20104 grants / $1,178,272

Does fresh frozen plasma in Russells viper bite coagulopathy reduce the dose and duration of antivenom therapy?$600,500

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamDoctor Geoff Isbister, Professor Nicholas Buckley, Professor Janaka de Silva, Conjoint Professor Andrew Dawson, Assoc. Prof David Lalloo
SchemeProject Grant
RoleLead
Funding Start2010
Funding Finish2010
GNoG0190172
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Multicentre studies of interventions in clinical toxicology and envenoming, including antivenoms and decontamination $417,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamDoctor Geoff Isbister
SchemeCareer Development Fellowships
RoleLead
Funding Start2010
Funding Finish2010
GNoG0900229
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Randomised controlled trial of intravenous antivenom versus placebo in the treatment of red back spider bite$148,772

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamDoctor Geoff Isbister, Associate Professor Simon Brown
SchemeProject Grant
RoleLead
Funding Start2010
Funding Finish2010
GNoG0900241
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

. Evaluation of the kinetics of blood clotting for assessing enoxaparin activity$12,000

Developing an assay to monitor low molecular weight heparins in patients.
Funding body: University of Otago

Funding bodyUniversity of Otago
Project Team
SchemeResearch Grant
RoleInvestigator
Funding Start2010
Funding Finish2011
GNo
Type Of FundingInternational - Competitive
Category3IFA
UONY

20091 grants / $300,000

Randomised controlled trial of intravenous antivenom versus placebo in the treatment of redback spider bite$300,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project Team
SchemeProject Grant
RoleLead
Funding Start2009
Funding Finish2010
GNo
Type Of FundingNot Known
CategoryUNKN
UONY

20081 grants / $689,500

A randomised controlled trial of factor replacement therapy in snake bite coagulopathy$689,500

Randomised controlled trial of fresh frozen plasma after antivenom administration in Australian snake bite coagulopathy - multicentre study across over 50 sites in 5 States.
Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project Team
SchemeProject Grant
RoleLead
Funding Start2008
Funding Finish2010
GNo
Type Of FundingNot Known
CategoryUNKN
UONY

20073 grants / $705,765

Mediators in Anaphylaxis$350,000

Developing mediator assays for patient with anaphylaxis presenting to emergency departments in NSW and WA.
Funding body: Food and Allergy Network

Funding bodyFood and Allergy Network
Project Team
SchemeUnknown
RoleInvestigator
Funding Start2007
Funding Finish2008
GNo
Type Of FundingInternational - Competitive
Category3IFA
UONY

Molecular toxinology of Australian Box jellyfish venoms$271,750

Isolation and characterisation of toxins in box jellyfish, including Chironex fleckeri.
Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project Team
SchemeProject Grant
RoleInvestigator
Funding Start2007
Funding Finish2010
GNo
Type Of FundingNot Known
CategoryUNKN
UONY

A randomised controlled trial of intramuscular droperidol for rapid sedation of aggressive and agitated psychostimulant-associated delirium$84,015

Funding body: NSW Health

Funding bodyNSW Health
Project Team
SchemeDrug and Alcohol Council Research Grants Program
RoleLead
Funding Start2007
Funding Finish2008
GNo
Type Of FundingAust Competitive - Non Commonwealth
Category1NS
UONY

20052 grants / $495,972

Prospective evaluation of terrestrial and marine envenoming in humans: clinical effects, predictors of severity, toxicokinetics and potential treatments$486,250

Fellowship to cover salary for multiple studies in clinical toxicology.
Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project Team
SchemeCareer Development Fellowships
RoleLead
Funding Start2005
Funding Finish2009
GNo
Type Of FundingNot Known
CategoryUNKN
UONY

A Randomised Controlled Trial of Hot Water (45°C) Immersion versus Ice Packs for Chironex fleckeri Stings$9,722

Funding body: Emergency Medicine Research Foundation Pty Ltd

Funding bodyEmergency Medicine Research Foundation Pty Ltd
Project Team
SchemeMorson Taylor Research Award
RoleLead
Funding Start2005
Funding Finish2005
GNo
Type Of FundingAust Competitive - Non Commonwealth
Category1NS
UONY

20041 grants / $9,651

A randomised controlled trial of warm water versus ice packs for acute treatment of blue bottle (Physalia spp.) stings$9,651

RCT of hot water for blue bottle stings.
Funding body: Calvary Mater Newcastle

Funding bodyCalvary Mater Newcastle
Project Team
SchemeMargaret Mitchell Grant
RoleLead
Funding Start2004
Funding Finish2005
GNo
Type Of FundingAust Competitive - Non Commonwealth
Category1NS
UONY

20032 grants / $7,500

PULSE Young Medical Researcher of the Year$5,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Geoff Isbister
SchemeResearch Grant
RoleLead
Funding Start2003
Funding Finish2003
GNoG0182734
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

North american Congress of Clinical Toxicology - 2003, Chicago, Illinois 4-9 September, 2003$2,500

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Geoff Isbister
SchemeTravel Grant
RoleLead
Funding Start2003
Funding Finish2003
GNoG0183162
Type Of FundingInternal
CategoryINTE
UONY

20023 grants / $20,400

Development of High Performance liquid chromatography for assaying tetrodotoxin in urine and correlation with clinical features in tetrodotoxin poisoning$12,500

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Geoff Isbister
SchemeNew Staff Grant
RoleLead
Funding Start2002
Funding Finish2002
GNoG0182662
Type Of FundingInternal
CategoryINTE
UONY

Paediatric Poisoning$5,400

Funding body: Childrens Hospital Fund

Funding bodyChildrens Hospital Fund
Project Team
SchemeSmall Grants Scheme
RoleInvestigator
Funding Start2002
Funding Finish2002
GNo
Type Of FundingExternal
CategoryEXTE
UONY

European Association of Poisons Centres and Clinical Toxicologists XXII International Congress, Lisbon Portugal, 22 - 25 May 2002$2,500

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Geoff Isbister
SchemeTravel Grant
RoleLead
Funding Start2002
Funding Finish2002
GNoG0181723
Type Of FundingInternal
CategoryINTE
UONY
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Research Supervision

Current Supervision

CommencedResearch Title / Program / Supervisor Type
2015Snake Envenoming in Australia and Beyond: Investigating Myotoxicity and the Early use of Antivenom
Pharmacology, Faculty of Health and Medicine
Principal Supervisor
2015Antidotes and Treatments in Overdose
Pharmacology, Faculty of Health and Medicine
Principal Supervisor
2014Cardiotoxicity of Drugs in Overdose
Pharmacology, Faculty of Health and Medicine
Principal Supervisor
2012Investigation of the Toxic Effects of Venoms From Sri Lankan Snakes and the Efficacy of Antivenoms.
Pharmacology, Faculty of Health and Medicine
Principal Supervisor
2010Sedation of Acute Behavioural Disturbance
General Medicine, Faculty of Health and Medicine
Principal Supervisor
2008Factors Contributing to Serotonin Toxicity
Pharmacology, Faculty of Health and Medicine
Principal Supervisor
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Dr Geoff Isbister

Position

Professor
School of Medicine and Public Health
Faculty of Health and Medicine

Contact Details

Emailgeoff.isbister@newcastle.edu.au
Phone(02) 4921 1627
Fax(02) 4960 2088

Office

RoomNM2 547
BuildingMater Hospital Level 5 - New Med 2
LocationCallaghan
University Drive
Callaghan, NSW 2308
Australia
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