Staff Profile

Edit

Career Summary

Qualifications

  • PhD (Medicine), University of Newcastle, 23/10/2008

Research

Research keywords

  • Biochemistry, Molecular Biology
  • Reproductive medicine, preterm birth, pregnancy

Research expertise

Reproductive Medicine, Protein Biochemistry, Tissue Culture, Immunocytochemistry, Immunology, Psychoimmunology, Virology, Molecular Biology, Conference Organisation, Data Management and Co-ordinator of Multicentre Clinical Trial.

Languages

  • English

Fields of Research

CodeDescriptionPercentage
111400Paediatrics And Reproductive Medicine65
110999Neurosciences Not Elsewhere Classified35
Edit

Publications

For publications that are currently unpublished or in-press, details are shown in italics.

Click on a category title below to expand the list of citations for that specific category.

Chapter (1 outputs)

YearCitationAltmetricsLink
2000Smith R, Changs E-C, Mesiano S, Nicholson R, Cheng Y-H, Bowman M, et al., 'Regulation of parturition: The role of CRH', Hormones and Women's Health The Reproductive Years, Harwood Academic Publishers, Amsterdam, The Netherlands 215-219 (2000) [B1]

Journal article (23 outputs)

YearCitationAltmetricsLink
2013Smith R, Zakar T, Madsen G, 'Mammalian Labor: Variations on a Theme by Amniota', ENDOCRINOLOGY, 154 584-588 (2013) [C1]
2012Chai S, Smith R, Zakar T, Mitchell CM, Madsen GM, 'Term myometrium is characterized by increased activating epigenetic modifications at the progesterone receptor-A promoter', Molecular Human Reproduction, 18 401-409 (2012) [C1]

Co-authors: ROGER SMITH

2012Smith R, Paul JW, Maiti K, Tolosa Gonzalez JM, Madsen GM, 'Recent advances in understanding the endocrinology of human birth', Trends in Endocrinology & Metabolism, 23 516-523 (2012) [C1]

Co-authors: ROGER SMITH

2009Merlino A, Welsh T, Erdonmez T, Madsen GM, Zakar T, Smith R, et al., 'Nuclear progesterone receptor expression in the human fetal membranes and decidua at term before and after labor', Reproductive Sciences, 16 357-363 (2009) [C1]
2007Madsen GM, Macintyre DA, Mesiano S, Smith R, 'Progesterone receptor or cytoskeletal protein?', Reproductive Sciences, 14 217-222 (2007) [C1]
2006Gill AW, Madsen GM, Knox M, Bisits AM, Giles WB, Tudehope D, et al., 'Neonatal neurodevelopmental outcomes following tocolysis with glycerol trinitrate patches', American Journal of Obstetrics and Gynecology, 195 484-487 (2006) [C1]
2004Madsen GM, Zakar T, Ku CY, Sanborn B, Smith R, Mesiano S, 'Prostaglandins Differentially Modulate Progesterone Receptor-A and -B Expression in Human Myometrial Cells: Evidence for Prostaglandin-Induced Functional Progesterone Withdrawal', Endocrinology and Metabolism, 89 1010-1013 (2004) [C1]
2004Madsen GM, Zakar T, Manuelpillai U, Wallace E, Kwek K, Yeo GS, et al., 'Intracrine Control of Estrogen Action in Human Gestational Tissues at Parturition', Society for Gynecologic Investigation. Journal, 11 213-219 (2004) [C1]
2004Bisits AM, Madsen GM, Knox M, Gill AW, Smith R, Yeo GS, et al., 'The Randomized Nitric Oxide Tocolysis Trial (RNOTT) for the treatment of preterm labor', American Journal of Obstetrics and Gynecology, 191 683-690 (2004) [C1]
2001Leung T, Chung T, Madsen GM, Lam P, Sahota D, Smith R, 'Rate of rise in maternal plasma corticotrohpin-releasing hormone and its relation to gestational length', BJOG: An international Journal of Obstetrics and Gynaecology, 108 527-532 (2001) [C1]

Co-authors: ROGER SMITH

2000Leung TN, Chung T, Madsen GM, Lam C, Lam P, Walters W, Smith R, 'Analysis of mid-trimester corticotrophin-releasing hormone and a-fetoprotein concentrations for predicting pre-eclampsia', Human Reproduction, 15 1813-1818 (2000) [C1]

Co-authors: ROGER SMITH

2000Giles W, Bisits A, Knox M, Madsen GM, Smith R, 'The effect of fetal fibronectin testing on admissions to a tertiary maternal-fetal medicine unit and cost savings', American Journal of Obstetrics and Gynecology, 182 439-442 (2000) [C1]

Co-authors: ROGER SMITH

2000Clifton VL, Qing G, Murphy VE, Schwartz J, Madsen GM, Smith R, 'Localization and Characterization of Urocortin during Human Pregancy', Placenta, 21 782-788 (2000) [C1]
1999Smith R, Wicking J, Bowman M, Belleoud A, Dubreuil G, Davies J, Madsen GM, 'Corticotropin-releasing hormone in chimpazee and gorilla pregnancies', Journal of clinical endocrinology and Metabolism, (Aug);84/8 2820-2825 (1999) [C1]
1999Leung TN, Chung T, Madsen GM, McLean M, Chang AMZ, Smith R, 'Elevated mid-trimester maternal coritcotropin-releasing hormone levels in pregnancies destined to deliver preterm before 34 weeks', British Jounal of Obsetrics and Gynecology, (Oct);106 1041-1046 (1999) [C1]

Co-authors: ROGER SMITH

1998Chan EC, Falconer J, Madsen GM, Rice KC, Webster EL, Chrousos GP, Smith R, 'Corticotropin-releasing hormone type 1 receptor antagonist delays parturition in sheep', Endocrinology, 139(7) 3357-3360 (1998) [C1]

Co-authors: ROGER SMITH

1998Bisits A, Madsen GM, McLean M, Ocallaghan S, Smith R, Giles W, 'Corticotropin-releasing hormone:a biochemical predictor of preterm delivery in a pilot randomised trial of the treatment of preterm labour', American Journal of Obstetrics and Gynaecology, 178(4) 862 (1998) [C1]

Co-authors: ROGER SMITH

1998Batey RG, Madsen GM, 'The carbohydrate-deficient transferrin test in hospital practice', Drug and Alcohol Review, 17 105-109 (1998) [C1]
1998Bisits AM, Madsen GM, McLean MT, Ocallaghan S, Smith R, Giles WB, 'CRH- a biomechnaical predictor of preterm delivery in a pilot randomised trial - of the treatment of preterm labour', American Journal of Obstetrics & Gynecology, 178 862-866 (1998) [C1]

Co-authors: ROGER SMITH

1988POWIS DA, MADSEN GM, TOROK TL, 'AUGMENTATION OF THE INDIRECT SYMPATHOMIMETIC ACTION OF TYRAMINE BY CARDIOACTIVE STEROIDS IS A CONSEQUENCE OF ELEVATED INTRACELLULAR SODIUM', NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 337 273-278 (1988)
1986POWIS DA, MADSEN GM, 'UNSUITABILITY OF THE RB-86(+) UPTAKE METHOD FOR ESTIMATION OF (NA+ + K+)-ATPASE ACTIVITY IN INNERVATED TISSUES', BIOCHIMICA ET BIOPHYSICA ACTA, 861 251-258 (1986)
1986POWIS DA, MADSEN GM, 'ALPHA-ADRENOCEPTOR-MEDIATED INCREASE IN TENSION AND EFFLUX OF RB-86 IN DOG SAPHENOUS-VEIN', BLOOD VESSELS, 23 95-96 (1986)
1986Powis DA, Madsen GM, 'Unsuitability of the 86Rb+ uptake method for estimation of (Na+ + K+)-ATPase activity in innervated tissues', BBA - Biomembranes, 861 251-258 (1986)
Show 20 more

Conference (7 outputs)

YearCitationAltmetricsLink
2012Chai S, Fitter JT, Smith R, Madsen GM, 'DNA methylation of progesterone receptor isoforms in term human myometrium', Abstracts. The Annual Scientific Meeting of the Endocrine Society of Australia and the Society for Reproductive Biology 2012, Gold Coast, QLD (2012) [E3]
2012Mitchell CM, Chai S, Madsen GM, Hirst JJ, Zakar T, 'Bivalent epigenetic modifications regulate PTGS2 expression during gestation in the amnion', Reproductive Sciences, San Diego, CA (2012) [E3]

Co-authors: JON HIRST

2011Chai SY, Smith R, Zakar T, Mitchell CM, Madsen GM, 'Term myometrium is characterized by increased activating epigenetic marks on the progesterone receptor A promoter', Reproductive Sciences, Miami Beach, Florida (2011) [E3]

Co-authors: ROGER SMITH

2010Chai S, Smith R, Madsen GM, 'Epigenetic regulation of progesterone receptor isoform expression in term human myometrium', The Endocrine Society of Australia Annual Scientific Meeting Proceedings and Abstract Book, Sydney (2010) [E3]

Co-authors: ROGER SMITH

2004Madsen GM, Zakar T, Chan EC, Yeo GS, Kwek K, Mesiano S, 'Prostaglandin Receptor Expression in Human Myometrium Before and After the Onset of Term Labor', Prostaglandin Receptor Expression in Human Myometrium Before and After the Onset of Term Labor, Texas (2004) [E3]
2001Giles WB, Knox M, Madsen GM, Bisits AM, Gill AW, Smith R, et al., 'The randomised nitric oxide tocolysis trial', American Journal of Obstetrics and Gynecology, Reno, Nevada (2001) [E3]
1998Giles WB, Knox M, Masden G, Bisits AM, Smith R, 'The effect of fetal fibronectin usage on admissions to a tertiary maternal fetal medicine unit and cost saving', American Journal of Obstetrics and Gynecology, Miami, 1998 (1998) [E1]

Co-authors: ROGER SMITH

Show 4 more
Edit

Grants and Funding

Summary

Number of grants10
Total funding$482,355

- Indicates that the researcher may be seeking students for this project.

Click on a grant title below to expand the full details for that specific grant.

2013 (1 grants)

Epigenetic Regulation of Progesterone Receptors and the Onset of Labour$23,810
Funding Body: John Hunter Hospital Charitable Trust Fund

Project Team
Doctor Gemma Madsen, Dr Sharyn Rayner
SchemeRole
Research GrantChief Investigator
Total AmountFunding StartFunding Finish
$23,81020132014
GNo:G1300703

2012 (2 grants)

The regulation of progesterone withdrawal in human parturition$34,454
Funding Body: John Hunter Hospital Charitable Trust Fund

Project Team
Doctor Gemma Madsen, Dr Sharyn Rayner
SchemeRole
Research GrantChief Investigator
Total AmountFunding StartFunding Finish
$34,45420122012
GNo:G1200642

Precellys Tissue Homogeniser$10,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Roger Smith, Professor Eugenie Lumbers, Conjoint Professor Tam Zakar, Professor Jon Hirst, Conjoint Professor Ian Wright, Doctor Gemma Madsen, Doctor Kaushik Maiti
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$10,00020122012
GNo:G1100979

2011 (1 grants)

Research microscope, confocal ready nikon eclipse 90i microscope$69,157
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Roger Smith, Conjoint Professor Tam Zakar, Professor Jon Hirst, Doctor Kaushik Maiti, Doctor Gemma Madsen, Professor Rodney Scott, Conjoint Professor Peter Wark, Professor Paul Foster, Professor Phil Hansbro, Conjoint Professor Ian Wright
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$69,15720112011
GNo:G1100024

2010 (1 grants)

Regulation of progesterone action in human parturition$303,750
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Doctor Gemma Madsen
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$303,75020102012
GNo:G0190155

2009 (1 grants)

Epigenetic regulation of progesterone receptor isoform expression in human myometrium$18,286
Funding Body: John Hunter Hospital Charitable Trust Fund

Project Team
Doctor Gemma Madsen
SchemeRole
Research GrantChief Investigator
Total AmountFunding StartFunding Finish
$18,28620092009
GNo:G0190236

2008 (1 grants)

Regulation of the differential expression of the A and B isoforms of the progesterone receptor in human parturition$15,208
Funding Body: John Hunter Hospital Charitable Trust Fund

Project Team
Doctor Gemma Madsen, Doctor Fatima Patel
SchemeRole
Research GrantChief Investigator
Total AmountFunding StartFunding Finish
$15,20820082008
GNo:G0189518

2005 (1 grants)

Society of Gynecologic Investigation 1st International Summit on Preterm Birth, 10-12 November 2005$1,220
Funding Body: University of Newcastle

Project Team
Doctor Gemma Madsen
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$1,22020052005
GNo:G0185914

2004 (1 grants)

Society of Gynecologic Investigation 51st Annual Scientific Meeting, 24 to 27 March 2004$1,470
Funding Body: University of Newcastle

Project Team
Doctor Gemma Madsen
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$1,47020042004
GNo:G0183892

2000 (1 grants)

Role of estrogen receptors (ERa and ERb) in the regulation of human parturition.$5,000
Funding Body: ARC (Australian Research Council)

Project Team
Doctor Sam Mesiano, Doctor Gemma Madsen
SchemeRole
Small GrantInvestigator
Total AmountFunding StartFunding Finish
$5,00020002000
GNo:G0178902
Edit

Research Supervision

Number of current supervisions2
Total current UoN PhD EFTSL1.05

For supervisions undertaken at an institution other that the University of Newcastle, the institution name is listed below the program name.

Current Supervision

CommencedProposed
Completion
ProgramSupervisor TypeResearch Title
20132017PhD (Reproductive Medicine)Co-SupervisorEpigenetic Regulation of Progesterone Receptors and the Onset of Labour
20092013PhD (Reproductive Medicine)Principal SupervisorEpigenetic Regulation of Progesterone Receptor Isoforms in Human Paturition
Edit

Dr Gemma Madsen

Work Phone(02) 4042 0359
Fax(02) 4042 0045
Email
PositionSenior Research Officer
Mothers and Babies Research Centre
School of Medicine and Public Health
Faculty of Health and Medicine
The University of Newcastle, Australia
Focus AreaReproductive Medicine
Office
3403-HMRI (Mothers and Babies Research Centre),
HMRI - John Hunter Hospital,
HMRI-John Hunter Hospital
URL:www.newcastle.edu.au/profile/gemma-madsen