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Dr Frances Neville

Conjoint Lecturer

School of Environmental and Life Sciences (Chemistry)

Career Summary

Biography

Dr Frances Neville is currently a Conjoint Lecturer at the School of Environmental and Life Sciences at the University of Newcastle, Australia. She has previously worked as a University Research Fellow within the same School, and as a Research Associate in Chemistry and Chemical Engineering, also at Newcastle. Prior to this she carried out postdoctoral research at the University of Leeds, UK where she obtained her PhD. She works in the fields of bionanotechnology, biochemical interfaces and materials chemistry. She has research expertise and experience in a range of scientific areas involving nanobiotechnology and functional surfaces/interfaces to investigate nanoparticle fabrication and characterisation, protein interactions and stability, novel protein drug delivery/detection methods and development of biosensors.

Research Expertise
I have significant nanobiotechnology expertise supported by a strong materials science background and am most productive in scientific areas involving functional surfaces and interfaces. However, my research experience demonstrates considerable breadth evidenced by my work in surface chemistry as well as in biophysical chemistry, electrochemistry, nanotechnology and protein biochemistry. The overall theme of my research is the understanding of interactions at the air-liquid and solid-liquid interface, in general involving physical, biochemical and inorganic chemistry. My PhD studies were carried out at the Institute for Materials Research, University of Leeds, UK, on a project entitled “Interactions of antimicrobial peptides with bacterial membranes”. The research focus was to study the mechanism of action of antimicrobial peptides to facilitate their use as novel antibiotic drugs, which could be used against drug-resistant bacteria because they interact with the lipid components of membranes rather than proteins. The mechanism of cell membrane penetration was investigated by observing peptide-lipid interactions t the air-aqueous interface using a range of biophysical and interface science techniques including X-ray scattering (reflectivity and grazing incidence X-ray diffraction), as well as Langmuir trough measurements and electrochemistry (circular voltammetry, conductance and impedance spectroscopy). My first postdoctoral position was at the Institute for Membrane and Systems Biology,University of Leeds, UK, where I was sponsored by competitive European Commission (EC) funding under the Nanotechnology theme of the Framework 6 program. The project involved the use of peptide mimics (polyamine polymers) to catalyse silica formation whilst entrapping biological components, such as enzymes, during the silica formation. Colloidal suspensions of silica particles were made as well as forming silica surfaces. A number of surface science methods including dynamic light scattering, scanning electron microscopy, X-ray photoelectron spectroscopy and infra-red spectroscopy were used to determine the optimal fabrication of the systems. The particles were also tested for bioactivity with the aim of using them for biosensor and biocatalysis applications. Since joining the University of Newcastle in 2009, I have worked predominantly in the area of colloid and interface science. In 2011 I was awarded a competitive University Research Fellowship. I am currently working on a number of independent research projects within the Discipline of Chemistry at the University of Newcastle. These projects involve the fabrication of colloidal inorganic-organic functional particles and surfaces which have combined properties including controllable surface polymer functionalities, magnetic properties and bioactivity from enzymes. The applications of these particles and surfaces include biosensors, biocatalysis, enhanced mineral separation and antifouling surfaces in marine and fresh water environments.

Teaching Expertise
I am currently teaching Chemical Instrumental Analysis (CHEM3110). I give lectures and tutorials and also act as a sole demonstrator for the whole of semester 1. I have previously taught Applied Chemistry (CHEM2510) and Pharmaceutical Chemistry (PHAR6114) at the University of Newcastle, giving lectures and tutorials. I have also carried out course development for several laboratory classes currently in use in CHEM3410 and CHEM3580.

Administrative Expertise
I am currently a peer-reviewer for: o Langmuir o Biomacromolecules o Journal of Chemical Education o Biomimetics and Bioinspiration o Physica Scripta o Philosophical Transactions A o Chemical Engineering Research and Design o Colloids and Surfaces B: Biointerfaces o Journal of Biotechnology o Sensors and Actuators B: Chemical o Journal of Nanoparticle Research o International Journal of Nanomedicine o Chemeca Conference I am also an Evaluator for the Executive Agency for Higher Education, Research, Development and Innovation Funding, Romania and the Royal Society of Chemistry and Nuffield Foundation, UK.

Collaborations
I have worked in interdisciplinary teams in differing fields such as biology, medicine, chemistry, physics and engineering. I currently collaborate with a number of academic staff in the disciplines of Chemistry, Chemical Engineering and Physics at the University of Newcastle in the areas of functional interfaces and nanotechnology. I also have international collaborators in the fields of biophysics and bionanotechnology in the USA and UK.


Qualifications

  • PhD, University of Leeds - UK
  • Bachelor of Science (Honours)(Biochemistry), University of Surrey - UK

Keywords

  • antimicrobial peptides
  • biocatalysis
  • biological interfaces
  • biosensors
  • instrumental chemical analysis
  • nanoparticles
  • surface science

Languages

  • Spanish (Fluent)

Fields of Research

CodeDescriptionPercentage
030306Synthesis of Materials50
090406Powder and Particle Technology25
100703Nanobiotechnology25

Professional Experience

UON Appointment

DatesTitleOrganisation / Department
1/01/2015 - 7/12/2015Casual AcademicUniversity of Newcastle
School of Environmental and Life Sciences
Australia
1/01/2013 - 31/12/2013UoN Postdoctoral Research FellowUniversity of Newcastle
School of Environmental and Life Sciences
Australia
9/08/2010 - 31/08/2010Casual AcademicUniversity of Newcastle
School of Environmental and Life Sciences
Australia
1/02/2010 - 14/05/2010Casual AcademicUniversity of Newcastle
School of Biomedical Sciences and Pharmacy
Australia

Academic appointment

DatesTitleOrganisation / Department
1/01/2011 - Membership - American Chemical SocietyAmerican Chemical Society
United States
1/01/2011 - 1/12/2013FellowUniversity of Newcastle
School of Environmental and Life Sciences
Australia
1/01/2007 - Membership - Royal Society of ChemistryRoyal Society of Chemistry
Australia
1/10/2001 - 1/09/2002Experimental OfficerCovance
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Chapter (1 outputs)

YearCitationAltmetricsLink
2011Neville FC, Millner P, 'Fabrication and characterization of bioactive thiol-silicate nanoparticles', Nanoscale Biocatalysis: Methods and Protocols, Springer, New York 131-145 (2011) [B1]
CitationsScopus - 1

Journal article (17 outputs)

YearCitationAltmetricsLink
2015Seyfaee A, Neville F, Moreno-Atanasio R, 'Experimental results and theoretical modeling of the growth kinetics of polyamine-derived silica particles', Industrial and Engineering Chemistry Research, 54 2466-2475 (2015)

Polyamine-derived silica particles are proposed to grow due to primary particle (<25 nm) aggregation. On the basis of material balance, we propose an aggregation model to predict ... [more]

Polyamine-derived silica particles are proposed to grow due to primary particle (<25 nm) aggregation. On the basis of material balance, we propose an aggregation model to predict the kinetics of polyamine-derived silica formation. The model is based on a rate equation consisting of two terms, representing both the production and aggregation of primary particles. The modeled rate constants were found to be a function of the concentration of silica precursor and biomimetic catalyst. Our experimental results agree with our model and suggest that the cube root of the silica precursor concentration is linearly proportional to particle diameter, as well as that below a critical concentration (~25 mM) no particles will be formed. If the concentration of reagents was high enough to produce particles with diameters greater than ~350 nm, other populations of particles, each of them growing at different rates, were necessary to describe the overall particle diameter observed, which was modeled as the average diameter of these different populations.

DOI10.1021/acs.iecr.5b00093
Co-authorsRoberto Moreno-Atanasio
2015Hyde ED, Moreno-Atanasio R, Millner PA, Neville F, 'Surface charge control through the reversible adsorption of a biomimetic polymer on silica particles.', J Phys Chem B, 119 1726-1735 (2015)
DOI10.1021/jp5100439Author URL
CitationsScopus - 1
Co-authorsRoberto Moreno-Atanasio
2014Seyfaee A, Moreno-Atanasio R, Neville F, 'High-resolution analysis of the influence of reactant concentration on nucleation time and growth of polyethyleneimine-trimethoxymethylsilane particles', Colloid and Polymer Science, (2014) [C1]

High-resolution dynamic light scattering (DLS), scanning electron microscopy (SEM), time-lapse photography, and attenuated total reflectance Fourier transform infrared spectroscop... [more]

High-resolution dynamic light scattering (DLS), scanning electron microscopy (SEM), time-lapse photography, and attenuated total reflectance Fourier transform infrared spectroscopy were used to analyze the growth kinetics of polyethyleneimine (PEI)-silica particles fabricated from the condensation of hydrolyzed trimethoxymethylsilane (TMOMS) and PEI/phosphate buffer (PEI/PB). Depending on the concentration of hydrolyzed TMOMS and PEI/PB, three stages were identified. We observed the existence of a nucleation time that has never been reported in the literature when TMOMS has been used. During this nucleation time, particles of less than 25 nm were detected using in situ DLS measurements taken every 15 s (high resolution), a DLS time-scale resolution not previously reported. In addition, the length of the nucleation time depended mainly on the PEI/PB concentration, but also TMOMS concentration. The growth stage was evident from the rapid increase of particle size with time. Due to the high resolution of the DLS measurements, a peak could be observed in the particle diameter during particle growth, which corresponds to a secondary population of particles required for the larger particles to further increase in size. Finally, during the equilibrium region, particles reached their maximum diameter that was independent of the concentration of PEI/PB and only changed with concentration of hydrolyzed TMOMS. © 2014 Springer-Verlag Berlin Heidelberg.

DOI10.1007/s00396-014-3312-y
CitationsScopus - 2Web of Science - 2
Co-authorsRoberto Moreno-Atanasio
2013Neville F, Seyfaee A, 'Real-time monitoring of in situ polyethyleneimine-silica particle formation.', Langmuir, 29 14681-14690 (2013) [C1]
DOI10.1021/la403040uAuthor URL
CitationsScopus - 3Web of Science - 3
2013Neville F, Murphy T, Wanless EJ, 'The formation of polyethyleneimine-trimethoxymethylsilane organic-inorganic hybrid particles', COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 431 42-50 (2013) [C1]
DOI10.1016/j.colsurfa.2013.04.022Author URL
CitationsScopus - 3Web of Science - 3
Co-authorsErica Wanless
2012Neville FC, Mohd Zin AB, Jameson GJ, Wanless EJ, 'Preparation and characterization of colloidal silica particles under mild conditions', Journal of Chemical Education, 89 940-942 (2012) [C1]
CitationsScopus - 5Web of Science - 5
Co-authorsGraeme Jameson, Erica Wanless
2011Neville FC, Broderick MJF, Gibson T, Millner PA, 'Fabrication and activity of silicate nanoparticles and nanosilicate- entrapped enzymes using polyethyleneimine as a biomimetic polymer', Langmuir, 27 279-285 (2011) [C1]
DOI10.1021/la1033492
CitationsScopus - 18Web of Science - 14
2010Neville FC, Ivankin A, Konovalov O, Gidalevitz D, 'A comparative study on the interactions of SMAP-29 with lipid monolayers', Biochimica et Biophysica Acta - Biomembranes, 1798 851-860 (2010) [C1]
DOI10.1016/j.bbamem.2009.09.017
CitationsScopus - 12Web of Science - 9
2009Neville F, Pchelintsev NA, Broderick MJF, Gibson T, Millner PA, 'Novel one-pot synthesis and characterization of bioactive thiol-silicate nanoparticles for biocatalytic and biosensor applications', Nanotechnology, 20 1-11 (2009) [C1]
DOI10.1088/0957-4484/20/5/055612
CitationsScopus - 10Web of Science - 10
2008Neville FC, Hodges CS, Ishitsuka Y, Lee KYC, Konovalov O, Waring AJ, et al., 'Protegrin interaction with lipid monolayers: Grazing incidence X-ray diffraction and X-ray reflectivity study', Soft Matter, 4 1665-1674 (2008) [C1]
DOI10.1039/b718295c
CitationsScopus - 20Web of Science - 19
2008Pchelintsev NA, Neville F, Millner PA, 'Biomimetic silication of surfaces and its application to preventing leaching of electrostatically immobilized enzymes', Sensors and Actuators B: Chemical: international journal devoted to research and development of physical and chemical transducers, 135 21-26 (2008) [C1]
DOI10.1016/j.snb.2008.07.015
CitationsScopus - 13Web of Science - 12
2007Neville F, Vakurov A, Broderick M, Millner P, 'Small solutions for greener chemistry', EBR - European Biopharmaceutical Review, 108-114 (2007) [C3]
2007Neville F, Gidalevitz D, Kale G, Nelson A, 'Electrochemical screening of anti-microbial peptide LL-37 interaction with phospholipids', BIOELECTROCHEMISTRY, 70 205-213 (2007) [C1]
DOI10.1016/j.bioelechem.2006.07.006Author URL
CitationsScopus - 9Web of Science - 7
2006Hodges CS, Neville F, Konovalov O, Hammond RB, Gidalevitz D, Hamley IW, 'Structural analysis of PEO-PBO copolymer monolayers at the air-water interface', LANGMUIR, 22 8821-8825 (2006) [C1]
DOI10.1021/la060632kAuthor URL
CitationsScopus - 8Web of Science - 8
2006Neville F, Hodges CS, Liu C, Konovalov O, Gidalevitz D, 'In situ characterization of lipid A interaction with antimicrobial peptides using surface X-ray scattering', BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1758 232-240 (2006) [C1]
DOI10.1016/j.bbamem.2006.01.025Author URL
CitationsScopus - 18Web of Science - 17
2006Neville F, Cahuzac M, Konovalov O, Ishitsuka Y, Lee KYC, Kuzmenko I, et al., 'Lipid headgroup discrimination by antimicrobial peptide LL-37: Insight into mechanism of action', BIOPHYSICAL JOURNAL, 90 1275-1287 (2006) [C1]
DOI10.1529/biophysj.105.067595Author URL
CitationsScopus - 63Web of Science - 60
2004Neville F, Cahuzac M, Nelson A, Gidalevitz D, 'The interaction of antimicrobial peptide LL-37 with artificial biomembranes: epifluorescence and impedance spectroscopy approach', JOURNAL OF PHYSICS-CONDENSED MATTER, 16 S2413-S2420 (2004) [C1]
DOI10.1088/0953-8984/16/26/014Author URL
CitationsScopus - 19Web of Science - 16
Show 14 more journal articles

Conference (7 outputs)

YearCitationAltmetricsLink
2012Neville FC, Moreno-Atanasio R, 'Magnetic interactions of core-shell composite particles: A combined experimental and simulation approach', Chemeca 2012 : Quality of life through chemical engineering, Wellington, NZ (2012) [E1]
Co-authorsRoberto Moreno-Atanasio
2011Neville FC, Murphy TI, Webber GB, Wanless EJ, Jameson GJ, 'Fabrication and characterisation of biomimetic silicate nanoparticles', Chemeca 2011: Engineering a Better World, Sydney (2011) [E1]
Co-authorsGrant Webber, Graeme Jameson, Erica Wanless
2007Broderick M, Neville F, Gibson T, Millner P, 'Practical nanobiotechnology: Functional nanoparticle production using silaffin R5 peptide', JOURNAL OF BIOTECHNOLOGY, Barcelona, SPAIN (2007)
DOI10.1016/j.jbiotec.2007.07.020Author URL
2007Millner P, Broderick M, Neville F, Vakurov A, Gibson T, 'Biosilicate and polymeric nanoparticulate solutions for biocatalysis', JOURNAL OF BIOTECHNOLOGY, Barcelona, SPAIN (2007)
DOI10.1016/j.jbiotec.2007.07.021Author URL
CitationsWeb of Science - 1
2007Neville F, Broderick M, Gibson T, Millner P, 'Synthesis and activity of nanosilicates and nanosilicate-entrapped enzymes using biomimetic polymers', JOURNAL OF BIOTECHNOLOGY, Barcelona, SPAIN (2007)
DOI10.1016/j.jbiotec.2007.07.173Author URL
CitationsWeb of Science - 2
2005Gidalevitz D, Neville F, 'Interaction of antimicrobial peptides with biomimetic membranes', BIOPHYSICAL JOURNAL, Long Beach, CA (2005)
Author URL
2004Neville F, Gidalevitz D, 'LL-37lipid interactions in membrane mimics', BIOPHYSICAL JOURNAL, Baltimore, MD (2004)
Author URL
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Grants and Funding

Summary

Number of grants4
Total funding$358,237

Click on a grant title below to expand the full details for that specific grant.


20121 grants / $9,935

Physically and biochemically active novel anti-fouling particles for incorporation into fresh water purification membranes$9,935

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Frances Neville
SchemeEarly Career Researcher Grant
RoleLead
Funding Start2012
Funding Finish2012
GNoG1200801
Type Of FundingInternal
CategoryINTE
UONY

20113 grants / $348,302

2010 Research Fellowship - PRCOE$333,302

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Frances Neville
SchemeResearch Fellowship
RoleLead
Funding Start2011
Funding Finish2011
GNoG1001011
Type Of FundingInternal
CategoryINTE
UONY

Nature-inspired silicates for stable multi-enzyme biosensors$12,450

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Frances Neville
SchemeFellowship Grant
RoleLead
Funding Start2011
Funding Finish2011
GNoG1001078
Type Of FundingInternal
CategoryINTE
UONY

Nature-inspired silicates for stable multi-enzyme biosensors$2,550

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Frances Neville
SchemeFellowship (Equipment) Grant
RoleLead
Funding Start2011
Funding Finish2011
GNoG1100398
Type Of FundingInternal
CategoryINTE
UONY
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Research Supervision

Current Supervision

CommencedResearch Title / Program / Supervisor Type
2014Optimisation of Silica Particle Fabrication and their Surface Properties Through Novel Synthesis Routes
Chemical Engineering, Faculty of Engineering and Built Environment
Co-Supervisor
2013Fabrication and Modelling of Core-Shell Composite Particles
Chemical Engineering, Faculty of Engineering and Built Environment
Co-Supervisor
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Dr Frances Neville

Positions

Conjoint Lecturer
Chemistry
School of Environmental and Life Sciences
Faculty of Science and Information Technology

Casual Academic
Chemistry
School of Environmental and Life Sciences
Faculty of Science and Information Technology

Casual Senior Research Assistant
Chemistry
School of Engineering
Faculty of Engineering and Built Environment

Focus area

Chemistry

Contact Details

Emailfrances.neville@newcastle.edu.au
Phone(02) 49216458
Fax(02) 49215472

Office

RoomC120
BuildingChemistry Building
LocationCallaghan
University Drive
Callaghan, NSW 2308
Australia
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