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Career Summary

Biography

Dr Frances Neville is currently a Conjoint Lecturer at the School of Environmental and Life Sciences at the University of Newcastle, Australia. She has previously worked as a University Research Fellow within the same School, and as a Research Associate in Chemistry and Chemical Engineering, also at Newcastle. Prior to this she carried out postdoctoral research at the University of Leeds, UK where she obtained her PhD. She works in the fields of bionanotechnology, biochemical interfaces and materials chemistry. She has research expertise and experience in a range of scientific areas involving nanobiotechnology and functional surfaces/interfaces to investigate nanoparticle fabrication and characterisation, protein interactions and stability, novel protein drug delivery/detection methods and development of biosensors.

Qualifications

  • PhD, University of Leeds - UK, 16/06/2006
  • Bachelor of Science (Honours)(Biochemistry), University of Surrey - UK, 15/06/2000

Research

Research keywords

  • antimicrobial peptides
  • biocatalysis
  • biological interfaces
  • biosensors
  • nanoparticles
  • surface science

Research expertise

I have significant nanobiotechnology expertise supported by a strong materials science background and am most productive in scientific areas involving functional surfaces and interfaces. However, my research experience demonstrates considerable breadth evidenced by my work in surface chemistry as well as in biophysical chemistry, electrochemistry, nanotechnology and protein biochemistry.

The overall theme of my research is the understanding of interactions at the air-liquid and solid-liquid interface, in general involving physical, biochemical and inorganic chemistry.

My PhD studies were carried out at the Institute for Materials Research, University of Leeds, UK, on a project entitled “Interactions of antimicrobial peptides with bacterial membranes”. The research focus was to study the mechanism of action of antimicrobial peptides to facilitate their use as novel antibiotic drugs, which could be used against drug-resistant bacteria because they interact with the lipid components of membranes rather than proteins. The mechanism of cell membrane penetration was investigated by observing peptide-lipid interactions t the air-aqueous interface using a range of biophysical and interface science techniques including X-ray scattering (reflectivity and grazing incidence X-ray diffraction), as well as Langmuir trough measurements and electrochemistry (circular voltammetry, conductance and impedance spectroscopy).

My first postdoctoral position was at the Institute for Membrane and Systems Biology,University of Leeds, UK, where I was sponsored by competitive European Commission (EC) funding under the Nanotechnology theme of the Framework 6 program. The project involved the use of peptide mimics (polyamine polymers) to catalyse silica formation whilst entrapping biological components, such as enzymes, during the silica formation. Colloidal suspensions of silica particles were made as well as forming silica surfaces. A number of surface science methods including dynamic light scattering, scanning electron microscopy, X-ray photoelectron spectroscopy and infra-red spectroscopy were used to determine the optimal fabrication of the systems. The particles were also tested for bioactivity with the aim of using them for biosensor and biocatalysis applications.

Since joining the University of Newcastle in 2009, I have worked predominantly in the area of colloid and interface science.

In 2011 I was awarded a competitive University Research Fellowship.

I am currently working on a number of independent research projects within the Discipline of Chemistry at the University of Newcastle. These projects involve the fabrication of colloidal inorganic-organic functional particles and surfaces which have combined properties including controllable surface polymer functionalities, magnetic properties and bioactivity from enzymes. The applications of these particles and surfaces include biosensors, biocatalysis, enhanced mineral separation and antifouling surfaces in marine and fresh water environments.

Languages

  • English
  • Spanish

Fields of Research

CodeDescriptionPercentage
030306Synthesis Of Materials50
100703Nanobiotechnology25
090406Powder And Particle Technology25

Memberships

Body relevant to professional practice.

  • Member - Royal Society of Chemistry
  • Member - American Chemical Society

Collaboration

I have worked in interdisciplinary teams in differing fields such as biology, medicine, chemistry, physics and engineering. I currently collaborate with a number of academic staff in the disciplines of Chemistry, Chemical Engineering and Physics at the University of Newcastle in the areas of functional interfaces and nanotechnology. I also have international collaborators in the fields of biophysics and bionanotechnology in the USA and UK.

Administrative

Administrative expertise

I am currently a peer-reviewer for:

  • Langmuir
  • Biomacromolecules
  • Journal of Chemical Education
  • Biomimetics and Bioinspiration
  • Physica Scripta
  • Philosophical Transactions A
  • Chemical Engineering Research and Design
  • Colloids and Surfaces B: Biointerfaces
  • Journal of Biotechnology
  • Sensors and Actuators B: Chemical
  • Journal of Nanoparticle Research
  • International Journal of Nanomedicine
  • Chemeca Conference

I am also an Evaluator for the Executive Agency for Higher Education, Research, Development and Innovation Funding, Romania and the Royal Society of Chemistry and Nuffield Foundation, UK.

Teaching

Teaching keywords

  • instrumental chemical analysis

Teaching expertise

I am currently teaching Chemical Instrumental Analysis (CHEM3110). I give lectures and tutorials and also act as a sole demonstrator for the whole of semester 1.

I have previously taught Applied Chemistry (CHEM2510) and Pharmaceutical Chemistry (PHAR6114) at the University of Newcastle, giving lectures and tutorials.

I have also carried out course development for several laboratory classes currently in use in CHEM3410 and CHEM3580.

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Highlighted Publications

For publications that are currently unpublished or in-press, details are shown in italics.

YearCitationAltmetricsLink
2014Seyfaee A, Moreno-Atanasio R, Neville F, 'High-resolution analysis of the influence of reactant concentration on nucleation time and growth of polyethyleneimine-trimethoxymethylsilane particles', Colloid and Polymer Science, (2014)
2013Neville F, Murphy T, Wanless EJ, 'The formation of polyethyleneimine-trimethoxymethylsilane organic-inorganic hybrid particles', COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 431 42-50 (2013) [C1]
2012Neville FC, Mohd Zin AB, Jameson GJ, Wanless EJ, 'Preparation and characterization of colloidal silica particles under mild conditions', Journal of Chemical Education, 89 940-942 (2012) [C1]
2011Neville FC, Broderick MJF, Gibson T, Millner PA, 'Fabrication and activity of silicate nanoparticles and nanosilicate- entrapped enzymes using polyethyleneimine as a biomimetic polymer', Langmuir, 27 279-285 (2011) [C1]
2006Neville F, Cahuzac M, Konovalov O, Ishitsuka Y, Lee KYC, Kuzmenko I, et al., 'Lipid headgroup discrimination by antimicrobial peptide LL-37: Insight into mechanism of action', BIOPHYSICAL JOURNAL, 90 1275-1287 (2006) [C1]
2008Pchelintsev NA, Neville F, Millner PA, 'Biomimetic silication of surfaces and its application to preventing leaching of electrostatically immobilized enzymes', Sensors and Actuators B: Chemical: international journal devoted to research and development of physical and chemical transducers, 135 21-26 (2008) [C1]
2006Neville F, Hodges CS, Liu C, Konovalov O, Gidalevitz D, 'In situ characterization of lipid A interaction with antimicrobial peptides using surface X-ray scattering', BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1758 232-240 (2006) [C1]
2013Neville F, Seyfaee A, 'Real-time monitoring of in situ polyethyleneimine-silica particle formation.', Langmuir, 29 14681-14690 (2013) [C1]

Publications

For publications that are currently unpublished or in-press, details are shown in italics.

Click on a category title below to expand the list of citations for that specific category.

Chapter (1 outputs)

YearCitationAltmetricsLink
2011Neville FC, Millner P, 'Fabrication and characterization of bioactive thiol-silicate nanoparticles', Nanoscale Biocatalysis: Methods and Protocols, Springer, New York 131-145 (2011) [B1]

Journal article (15 outputs)

YearCitationAltmetricsLink
2014Seyfaee A, Moreno-Atanasio R, Neville F, 'High-resolution analysis of the influence of reactant concentration on nucleation time and growth of polyethyleneimine-trimethoxymethylsilane particles', Colloid and Polymer Science, (2014)
2013Neville F, Murphy T, Wanless EJ, 'The formation of polyethyleneimine-trimethoxymethylsilane organic-inorganic hybrid particles', COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 431 42-50 (2013) [C1]
2013Neville F, Seyfaee A, 'Real-time monitoring of in situ polyethyleneimine-silica particle formation.', Langmuir, 29 14681-14690 (2013) [C1]
2012Neville FC, Mohd Zin AB, Jameson GJ, Wanless EJ, 'Preparation and characterization of colloidal silica particles under mild conditions', Journal of Chemical Education, 89 940-942 (2012) [C1]
2011Neville FC, Broderick MJF, Gibson T, Millner PA, 'Fabrication and activity of silicate nanoparticles and nanosilicate- entrapped enzymes using polyethyleneimine as a biomimetic polymer', Langmuir, 27 279-285 (2011) [C1]
2010Neville FC, Ivankin A, Konovalov O, Gidalevitz D, 'A comparative study on the interactions of SMAP-29 with lipid monolayers', Biochimica et Biophysica Acta - Biomembranes, 1798 851-860 (2010) [C1]
2009Neville F, Pchelintsev NA, Broderick MJF, Gibson T, Millner PA, 'Novel one-pot synthesis and characterization of bioactive thiol-silicate nanoparticles for biocatalytic and biosensor applications', Nanotechnology, 20 1-11 (2009) [C1]
2008Pchelintsev NA, Neville F, Millner PA, 'Biomimetic silication of surfaces and its application to preventing leaching of electrostatically immobilized enzymes', Sensors and Actuators B: Chemical: international journal devoted to research and development of physical and chemical transducers, 135 21-26 (2008) [C1]
2008Neville FC, Hodges CS, Ishitsuka Y, Lee KYC, Konovalov O, Waring AJ, et al., 'Protegrin interaction with lipid monolayers: Grazing incidence X-ray diffraction and X-ray reflectivity study', Soft Matter, 4 1665-1674 (2008) [C1]
2007Neville F, Gidalevitz D, Kale G, Nelson A, 'Electrochemical screening of anti-microbial peptide LL-37 interaction with phospholipids', BIOELECTROCHEMISTRY, 70 205-213 (2007) [C1]
2007Neville F, Vakurov A, Broderick M, Millner P, 'Small solutions for greener chemistry', EBR - European Biopharmaceutical Review, 108-114 (2007) [C3]
2006Hodges CS, Neville F, Konovalov O, Hammond RB, Gidalevitz D, Hamley IW, 'Structural analysis of PEO-PBO copolymer monolayers at the air-water interface', LANGMUIR, 22 8821-8825 (2006) [C1]
2006Neville F, Hodges CS, Liu C, Konovalov O, Gidalevitz D, 'In situ characterization of lipid A interaction with antimicrobial peptides using surface X-ray scattering', BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1758 232-240 (2006) [C1]
2006Neville F, Cahuzac M, Konovalov O, Ishitsuka Y, Lee KYC, Kuzmenko I, et al., 'Lipid headgroup discrimination by antimicrobial peptide LL-37: Insight into mechanism of action', BIOPHYSICAL JOURNAL, 90 1275-1287 (2006) [C1]
2004Neville F, Cahuzac M, Nelson A, Gidalevitz D, 'The interaction of antimicrobial peptide LL-37 with artificial biomembranes: epifluorescence and impedance spectroscopy approach', JOURNAL OF PHYSICS-CONDENSED MATTER, 16 S2413-S2420 (2004) [C1]
Show 12 more

Conference (7 outputs)

YearCitationAltmetricsLink
2012Neville FC, Moreno-Atanasio R, 'Magnetic interactions of core-shell composite particles: A combined experimental and simulation approach', Chemeca 2012 : Quality of life through chemical engineering, Wellington, NZ (2012) [E1]
2011Neville FC, Murphy TI, Webber GB, Wanless EJ, Jameson GJ, 'Fabrication and characterisation of biomimetic silicate nanoparticles', Chemeca 2011: Engineering a Better World, Sydney (2011) [E1]
2007Neville F, Broderick M, Gibson T, Millner P, 'Synthesis and activity of nanosilicates and nanosilicate-entrapped enzymes using biomimetic polymers', JOURNAL OF BIOTECHNOLOGY, Barcelona, SPAIN (2007)
2007Broderick M, Neville F, Gibson T, Millner P, 'Practical nanobiotechnology: Functional nanoparticle production using silaffin R5 peptide', JOURNAL OF BIOTECHNOLOGY, Barcelona, SPAIN (2007)
2007Millner P, Broderick M, Neville F, Vakurov A, Gibson T, 'Biosilicate and polymeric nanoparticulate solutions for biocatalysis', JOURNAL OF BIOTECHNOLOGY, Barcelona, SPAIN (2007)
2005Gidalevitz D, Neville F, 'Interaction of antimicrobial peptides with biomimetic membranes', BIOPHYSICAL JOURNAL, Long Beach, CA (2005)
2004Neville F, Gidalevitz D, 'LL-37lipid interactions in membrane mimics', BIOPHYSICAL JOURNAL, Baltimore, MD (2004)
Show 4 more
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Grants and Funding

Summary

Number of grants4
Total funding$358,237

- Indicates that the researcher may be seeking students for this project.

Click on a grant title below to expand the full details for that specific grant.

2012 (1 grants)

Physically and biochemically active novel anti-fouling particles for incorporation into fresh water purification membranes$9,935
Funding Body: University of Newcastle

Project Team
Doctor Frances Neville
SchemeRole
Early Career Researcher GrantChief Investigator
Total AmountFunding StartFunding Finish
$9,93520122012
GNo:G1200801

2011 (3 grants)

2010 Research Fellowship - PRCOE$333,302
Funding Body: University of Newcastle

Project Team
Doctor Frances Neville
SchemeRole
Research FellowshipChief Investigator
Total AmountFunding StartFunding Finish
$333,30220112013
GNo:G1001011

Nature-inspired silicates for stable multi-enzyme biosensors$12,450
Funding Body: University of Newcastle

Project Team
Doctor Frances Neville
SchemeRole
Fellowship GrantChief Investigator
Total AmountFunding StartFunding Finish
$12,45020112011
GNo:G1001078

Nature-inspired silicates for stable multi-enzyme biosensors$2,550
Funding Body: University of Newcastle

Project Team
Doctor Frances Neville
SchemeRole
Fellowship (Equipment) GrantChief Investigator
Total AmountFunding StartFunding Finish
$2,55020112011
GNo:G1100398
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Research Supervision

Number of current supervisions2
Total current UoN PhD EFTSL1

For supervisions undertaken at an institution other that the University of Newcastle, the institution name is listed below the program name.

Current Supervision

CommencedProposed
Completion
ProgramSupervisor TypeResearch Title
20142018PhD (Chemical Engineering)Co-SupervisorDesigner Anti-Fouling Particles for Marine Environments and Fresh Water Purification Systems
20132017PhD (Chemical Engineering)Co-SupervisorFabrication and Modelling of Core-Shell Composite Particles
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Dr Frances Neville

Work Phone(02) 49216458
Fax(02) 49215472
Email
PositionsConjoint Lecturer
School of Environmental and Life Sciences
Faculty of Science and Information Technology
The University of Newcastle, Australia
Casual Academic
School of Environmental and Life Sciences
Faculty of Science and Information Technology
The University of Newcastle, Australia
Focus AreaChemistry
Office
C120,
Chemistry Building,
Callaghan
University Drive
Callaghan NSW 2308
Australia
URL:www.newcastle.edu.au/profile/frances-neville