Profile Image

Dr Fatemeh Moheimani

Post Doctoral Research Fellow

School of Biomedical Sciences and Pharmacy

Career Summary

Biography

Fatemeh graduated from Faculty of Pharmacy, Shiraz, Iran with the Doctorate degree in Pharmacy (Pharm-D). She then moved to Australia to pursue her research career. Fatemeh completed her Master of Medical Science (by research: the effect of a novel polyunsaturated fatty acid on development of atherosclerosis in apoE deficient mice) at University of Adelaide in 2005 and her PhD (molecular mechanisms linking diabetes with atherosclerosis) at University of Sydney in 2009. She was offered various scholarships, travel grants and postgraduate grants, e.g. GlaxoSmithKline postgraduate grant (2007-2008: $25,000) during her postgraduate trainings. She also worked as a researcher and taught in various Medical Institutes and Universities. 

Fatemeh was offered her postdoctoral research fellow at RMIT University in 2010 where she was investigating molecular mechanisms that regulate platelet thrombus formation. During her position at RMIT, Fatemeh co-supervised several Masters and PhD students, acted as postdoctoral representative in school of medical sciences, was successful in obtaining several travel grants and attended prestigious national and international conferences such as Australian Vascular Biology Society (AVBS) meeting (2012), the Gordon Research Conference-Haemostasis, New Hampshire, USA (2012) and the International Society on Thrombosis and Haemostasis, Kyoto, Japan (2011).

Fatemeh was then offered her postdoctoral fellow position in Respiratory Cell and Molecular Biology area at School of Biomedical Sciences and Pharmacy, University of Newcastle, in 2013, under the supervision of Prof Knight. She has established Prof Knight’s laboratory and collaborated closely with expertise in the field, including Prof Peter Wark and Prof Philip Hansbro to investigate the importance of tissue and cell specific mechanisms that contribute to the respiratory diseases, particularly asthma. Fatemeh is addressing how the structure and function of epithelial cells contribute to asthma. 

Research Expertise
Fatemeh is a research scientist with background in Biochemistry/Pharmacy and extensive medical research experience in cardiovascular field. The outcomes of her research have revealed essential molecular mechanisms linking diabetes with atherosclerosis. Fatemeh has expanded her research expertise to the respiratory field since 2013. She is particularly interested in asthma and investigating the importance of tissue and cell specific mechanisms that contribute to the disease. Fatemeh is addressing how the structure and function of epithelial cells contribute to asthma.

Teaching Expertise
Fatemeh’s has acted as co-supervisor of Masters and PhD students. She also acted as academic supervisor of 8 undergraduate students of professional practice in Discipline of Laboratory Medicine, RMIT University with 100% and 78% good teaching score in 2013. In addition, she has teaching experience as practical tutor in subjects of ‘Traditional Chinese medicine’, ‘Medical science 1’, ‘Medical science 2’, and ‘Essentials of Pathophysiology’ in UTS from 2006 to 2008 as well as teaching in Microbial control of medicines lab and Industrial pharmacy lab in Faculty of Pharmacy, Shiraz, Iran from 2001 to 2002. 

Qualifications

  • PhD (Medicine), University of Sydney
  • Master of Medical Science, University of Adelaide
  • Doctor of Pharmacy (PhD), Shiraz University - Iran

Keywords

  • Asthma
  • Atherosclerosis
  • Diabetes
  • Haemostasis
  • Medical science
  • Pharmaceutics
  • Pharmacology
  • Professional practice in Discipline of Laboratory Medicine, RMIT University

Languages

  • Persian (excluding Dari) (Fluent)

Fields of Research

Code Description Percentage
110203 Respiratory Diseases 100

Professional Experience

UON Appointment

Title Organisation / Department
Post Doctoral Research Fellow University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia

Academic appointment

Dates Title Organisation / Department
1/04/2013 -  Postdoctoral Fellow University of Newcastle
Australia
1/01/2013 -  Membership - The Thoracic Society of Australia and New Zealand The Thoracic Society of Australia and New Zealand
Australia
1/01/2010 - 1/03/2013 Postdoctoral Research Fellow RMIT University
School of Medical Sciences
1/01/2010 - 31/12/2012 Membership - Australian Vascular Biology Society Australian Vascular Biology Society
Australia
1/01/2010 - 1/03/2013 Postdoctoral Research Fellow RMIT University
1/08/2009 - 1/12/2009 Research Scientist The Heart Research Institute, Sydney
Australia
1/08/2009 - 1/12/2009 Research Scientist The Heart Research Institute, Sydney
Australia
1/01/2007 - 31/12/2009 Membership - Australian Atherosclerosis Society ASM Australian Atherosclerosis Society ASM
Australia
1/07/2006 - 1/06/2008 Practical Tutor University of Technology Sydney
Department of Medical and Molecular Biosciences
Australia
1/09/2005 - 1/01/2006 Research Assistant Flinders Medical Centre, SA
Department of Medical Biochemistry, School of Medicine
Australia
1/01/2003 - 1/03/2003 Research Assistant University of Newcastle
Discipline of Experimental Pharmacology, School of Biomedical Science, Faculty of Health
Australia
1/12/2001 - 1/10/2002 Teaching and Research Assistant Shiraz University of Medical Sciences, Iran
Faculty of Pharmacy
Iran, Islamic Republic of
1/01/2001 - 31/12/2006 Membership - Pharmacist Association, Registered Pharmacist Iranian Pharmacist Association
Australia

Awards

Recipient

Year Award
2014 Early Career Researcher Grant
Unknown

Research Award

Year Award
2014 New Staff Grant
Unknown
2014 John Hunter Hospital Charitable Trust
Unknown
2013 Hunter Medical Research Institute PROJECT FUNDING
Hunter Medical Research Institute
2012 CASS Foundation Travel Grant
Unknown
2012 RMIT Travel Grant
RMIT University
2011 Japanese Society on Thrombosis and Haemostasis Asian-Pacific Scholarship (JSTH/APS)
Unknown
2011 RMIT Travel Grant
Unknown
2008 Postgraduate Research Support Scheme (PRSS)
Unknown
2007 GlaxoSmithKline (GSK) Postgraduate Grant Support
Unknown
2007 Postgraduate Research Support Scheme (PRSS)
Unknown
2006 Australian Postgraduate Award (APA)
University of Sydney
2003 Departmental Postgraduate Scholarship
University of Adelaide
Edit

Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Journal article (13 outputs)

Year Citation Altmetrics Link
2016 Hsu AC, Parsons K, Moheimani F, Knight DA, Hansbro PM, Fujita T, Wark PA, 'Impaired Antiviral Stress Granule and IFN-ß Enhanceosome Formation Enhances Susceptibility to Influenza Infection in COPD Epithelium.', Am J Respir Cell Mol Biol, (2016)
DOI 10.1165/rcmb.2015-0306OC
Co-authors Darryl Knight, Alan Hsu
2015 Sercombe L, Veerati T, Moheimani F, Wu SY, Sood AK, Hua S, 'Advances and challenges of liposome assisted drug delivery', Frontiers in Pharmacology, 6 (2015) [C1]

© 2015 Sercombe, Veerati, Moheimani, Wu, Sood and Hua. The application of liposomes to assist drug delivery has already had a major impact on many biomedical areas. They have bee... [more]

© 2015 Sercombe, Veerati, Moheimani, Wu, Sood and Hua. The application of liposomes to assist drug delivery has already had a major impact on many biomedical areas. They have been shown to be beneficial for stabilizing therapeutic compounds, overcoming obstacles to cellular and tissue uptake, and improving biodistribution of compounds to target sites in vivo. This enables effective delivery of encapsulated compounds to target sites while minimizing systemic toxicity. Liposomes present as an attractive delivery system due to their flexible physicochemical and biophysical properties, which allow easy manipulation to address different delivery considerations. Despite considerable research in the last 50 years and the plethora of positive results in preclinical studies, the clinical translation of liposome assisted drug delivery platforms has progressed incrementally. In this review, we will discuss the advances in liposome assisted drug delivery, biological challenges that still remain, and current clinical and experimental use of liposomes for biomedical applications. The translational obstacles of liposomal technology will also be presented.

DOI 10.3389/fphar.2015.00286
Co-authors Susan Hua
2015 Hirota JA, Marchant DJ, Singhera GK, Moheimani F, Dorscheid DR, Carlsten C, et al., 'Urban particulate matter increases human airway epithelial cell IL-1ß secretion following scratch wounding and H1N1 influenza A exposure in vitro.', Exp Lung Res, 41 353-362 (2015)
DOI 10.3109/01902148.2015.1040528
Co-authors Darryl Knight
2015 Moheimani F, Roth HM, Cross J, Reid AT, Shaheen F, Warner SM, et al., 'Disruption of ß-catenin/CBP signaling inhibits human airway epithelial-mesenchymal transition and repair', International Journal of Biochemistry and Cell Biology, 68 59-69 (2015) [C1]

© 2015 Elsevier Ltd. The epithelium of asthmatics is characterized by reduced expression of E-cadherin and increased expression of the basal cell markers ck-5 and p63 that is ind... [more]

© 2015 Elsevier Ltd. The epithelium of asthmatics is characterized by reduced expression of E-cadherin and increased expression of the basal cell markers ck-5 and p63 that is indicative of a relatively undifferentiated repairing epithelium. This phenotype correlates with increased proliferation, compromised wound healing and an enhanced capacity to undergo epithelial-mesenchymal transition (EMT). The transcription factor ß-catenin plays a vital role in epithelial cell differentiation and regeneration, depending on the co-factor recruited. Transcriptional programs driven by the ß-catenin/CBP axis are critical for maintaining an undifferentiated and proliferative state, whereas the ß-catenin/p300 axis is associated with cell differentiation. We hypothesized that disrupting the ß-catenin/CBP signaling axis would promote epithelial differentiation and inhibit EMT. We treated monolayer cultures of human airway epithelial cells with TGFß1 in the presence or absence of the selective small molecule ICG-001 to inhibit ß-catenin/CBP signaling. We used western blots to assess expression of an EMT signature, CBP, p300, ß-catenin, fibronectin and ITGß1 and scratch wound assays to assess epithelial cell migration. Snai-1 and -2 expressions were determined using q-PCR. Exposure to TGFß1 induced EMT, characterized by reduced E-cadherin expression with increased expression of a-smooth muscle actin and EDA-fibronectin. Either co-treatment or therapeutic administration of ICG-001 completely inhibited TGFß1-induced EMT. ICG-001 also reduced the expression of ck-5 and -19 independent of TGFß1. Exposure to ICG-001 significantly inhibited epithelial cell proliferation and migration, coincident with a down regulation of ITGß1 and fibronectin expression. These data support our hypothesis that modulating the ß-catenin/CBP signaling axis plays a key role in epithelial plasticity and function.

DOI 10.1016/j.biocel.2015.08.014
Co-authors Darryl Knight, Philip Hansbro
2015 Makkawi M, Moheimani F, Alserihi R, Howells D, Wright M, Ashman L, Jackson DE, 'A complementary role for tetraspanin superfamily member CD151 and ADP purinergic P2Y12 receptor in platelets.', Thromb Haemost, 114 1004-1019 (2015)
DOI 10.1160/TH14-11-0967
2014 Alshahrani MM, Yang E, Yip J, Ghanem SS, Abdallah SL, de Angelis AM, et al., 'CEACAM2 negatively regulates hemi (ITAM-bearing) GPVI and CLEC-2 pathways and thrombus growth in vitro and in vivo', BLOOD, 124 2431-2441 (2014) [C1]
DOI 10.1182/blood-2014-04-569707
Citations Scopus - 6Web of Science - 2
2012 Moheimani F, Kim CHJ, Rahmanto AS, van Reyk DM, Davies MJ, 'Inhibition of lysosomal function in macrophages incubated with elevated glucose concentrations: A potential contributory factor in diabetes-associated atherosclerosis', ATHEROSCLEROSIS, 223 144-151 (2012) [C1]
DOI 10.1016/j.atherosclerosis.2012.04.026
Citations Scopus - 4Web of Science - 4
2012 Moheimani F, Jackson DE, 'P2Y(12) receptor: platelet thrombus formation and medical interventions', INTERNATIONAL JOURNAL OF HEMATOLOGY, 96 572-587 (2012) [C3]
DOI 10.1007/s12185-012-1188-5
Citations Scopus - 6Web of Science - 4
2011 Moheimani F, Tan JTM, Brown BE, Heather AK, van Reyk DM, Davies MJ, 'Effect of Exposure of Human Monocyte-Derived Macrophages to High, versus Normal, Glucose on Subsequent Lipid Accumulation from Glycated and Acetylated Low-Density Lipoproteins', EXPERIMENTAL DIABETES RESEARCH, (2011) [C1]
DOI 10.1155/2011/851280
Citations Scopus - 1Web of Science - 1
2011 Moheimani F, Jackson DE, 'Venous thromboembolism: classification, risk factors, diagnosis, and management.', ISRN hematology, 2011 124610 (2011) [C1]
DOI 10.5402/2011/124610
2010 Moheimani F, Moore L, Ferrante JV, Trout N, Hii CS, Ferrante A, 'Inhibition of Atherosclerotic Lesion Development in the ApoE(-/-) Mouse by a Novel beta-oxa Polyunsaturated Fatty Acid', JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 56 431-439 (2010) [C1]
DOI 10.1097/FJC.0b013e3181f1d420
Citations Scopus - 2Web of Science - 2
2010 Moheimani F, Morgan PE, van Reyk DM, Davies MJ, 'Deleterious effects of reactive aldehydes and glycated proteins on macrophage proteasomal function: Possible links between diabetes and atherosclerosis', BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1802 561-571 (2010) [C1]
DOI 10.1016/j.bbadis.2010.02.007
Citations Scopus - 18Web of Science - 17
2003 Moheimani F, Bahri Najafi R, Mohammadi Samania S, Pishvab N, 'Formulation and Clinical Evaluation of Povidone-Iodine Ophthalmic Drop', Iranian Journal of Pharmaceutical Research, 2 157-160 (2003)
Show 10 more journal articles

Conference (3 outputs)

Year Citation Altmetrics Link
2015 Moheimani F, Roth H, Cross J, Reid A, Shaheen F, Warner S, et al., 'SUPPRESSION OF beta-CATENIN/CBP SIGNALING INHIBITS EPITHELIAL-MESENCHYMAL TRANSITION AND MIGRATION OF HUMAN AIRWAY EPITHELIUM', RESPIROLOGY (2015)
Co-authors Philip Hansbro, Darryl Knight
2011 Moheimani F, Ashman LK, Wright MD, Jackson DE, 'Novel molecular association of ADP purinergic receptor, P2Y12 with tetraspanin superfamily member, CD151 in human platelets', JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2011)
Co-authors Leonie Ashman
2008 Moheimani F, van Reyk DM, Davies MJ, 'Do glucose and reactive aldehydes modulate the removal of glycated proteins by proteasomes?', ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2008) [E3]
Edit

Grants and Funding

Summary

Number of grants 3
Total funding $42,512

Click on a grant title below to expand the full details for that specific grant.


20142 grants / $32,512

Mechanisms of dysregulated antiviral signallings to influenza infection in chronic obstructive pulmonary disease$27,512

Funding body: John Hunter Hospital Charitable Trust

Funding body John Hunter Hospital Charitable Trust
Project Team Doctor Alan Hsu, Doctor Fatemeh Moheimani, Professor Darryl Knight, Conjoint Professor Peter Wark
Scheme Research Grant
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1400435
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Role of the transcriptional co-activator p300 in resetting epithelial differentiation: A potential pathway involved in asthma prevention and therapy$5,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Doctor Fatemeh Moheimani
Scheme New Staff Grant
Role Lead
Funding Start 2014
Funding Finish 2014
GNo G1301262
Type Of Funding Internal
Category INTE
UON Y

20131 grants / $10,000

Role of the transcriptional co-activator p300 in resetting epithelial differentiation: A potential pathway involved in asthma prevention and therapy$10,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Doctor Fatemeh Moheimani, Professor Darryl Knight, Ms Kirsty Wark, Doctor Alan Hsu, Doctor Malcolm Starkey
Scheme Early Career Researcher Grant
Role Lead
Funding Start 2013
Funding Finish 2013
GNo G1301174
Type Of Funding Internal
Category INTE
UON Y
Edit

Research Supervision

Number of supervisions

Completed3
Current1

Total current UON EFTSL

PhD0.2

Current Supervision

Commenced Level of Study Research Title / Program / Supervisor Type
2015 PhD Role of Mechanical Forces in Asthma Pathogenesis
PhD (Medicine), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor

Past Supervision

Year Level of Study Research Title / Program / Supervisor Type
2015 PhD Tyrosine kinase inhibitors modulate platelet reactivity and platelet function
Medical Science, RMIT University
Co-Supervisor
2014 PhD Investigating novel platelet immunoreceptors ‘CEACAM2’ in contact-dependent events that modulate platelet thrombus formation
Medical Science, RMIT University
Co-Supervisor
2012 Masters Physical association of ADP purinergic receptor, P2Y12, with tetraspanin CD151 on human platelets
Medical Science, RMIT University
Co-Supervisor
Edit

News

PhD Scholarship - Role of mechanical forces in asthma pathogenesis

PhD Scholarship - Role of mechanical forces in asthma pathogenesis

July 30, 2014

Applications are open for a PhD scholarship at the University of Newcastle. As the successful applicant you will undertake your doctoral studies in the Priority Research Centre for Asthma and Respiratory Disease at the Hunter Medical Research Institute in Newcastle.

Dr Fatemeh Moheimani

Position

Post Doctoral Research Fellow
The Priority Research Centre for Asthma and Respiratory Diseases
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

Contact Details

Email fatemeh.moheimani@newcastle.edu.au
Phone (02) 40420363

Office

Room HMRI 2101
Building The Hunter Medical Research Institute
Location The University of Newcastle

,
Edit