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Associate Professor Estelle Sontag

Associate Professor

School of Biomedical Sciences and Pharmacy (Medical Biochemistry)

Career Summary

Biography

After obtaining her PhD in Neuroscience in 1992 from the University Louis-Pasteur in Strasbourg, France, Dr. Estelle Sontag undertook postdoctoral training and was promoted in 2003 to the rank of Associate Professor of Pathology at UT Southwestern Medical Center at Dallas, TX, a top-ranked Medical school in the USA. Since 2009, she is Associate Professor at the Faculty of Health, School of Biomedical Sciences & Pharmacy, at the University of Newcastle, NSW, Australia.

Dr. Sontag is internationally recognized in the field of protein phosphatase 2A, having made several significant contributions to the field by unveiling the role of this major enzyme in signal transduction, viral-mediated cell transformation and neurodegeneration (h-index 26; >3000 citations). Over the years, her work has provided novel fundamental insights into the role of PP2A in the regulation of growth signaling pathways (Cell, 1993; EMBO J., 1997), cell adhesion (J. Cell Biol., 2002; J Virol 2003) and cytoskeletal proteins (J. Cell Biol., 1995; Neuron, 1996; J. Neurochem 2007; J. Biol. Chem., 2012). Current research is focused more specifically on studying the regulation and role of PP2A methylation, with an emphasis on its role in tauopathies, including Alzheimer’s disease (J Neuropath Exp Neur. 2004; J. Neurochem 2010; J. Neuroscience 2007, 2008, 2012; J. Biol. Chem., 2012, 2013; Frontiers in Molecular Neuroscience, 2014), in collaboration with many international researchers.

Dr. Sontag is regularly invited as speaker at national and international meetings. She is also a member of international journal editorial and grant reviewing boards.

Research Expertise
- Biochemist and molecular and cell biologist with 20 years expertise in the field of protein phosphatase 2A and its role in signal transduction, cell transformation and Alzheimer’s disease. - Continuous research funding by the NIH in the USA and the NHMRC in Australia.

Teaching Expertise
MEDI1012 Introduction to Medical Science - Lecturer MEDI1015 Medical Science 1 - Lecturer MEDI2012 Medical Science 2 - Lecturer MEDI2014 Medical Science 3 - Lecturer MEDI3017 Chronic Diseases and Sub-Speciality Clinical Practice 1- Lecturer MEDI3018 Chronic Diseases and Sub-Speciality Clinical Practice 2- Lecturer PHAR6123 Human Genomics and Biomolecular Analysis for Pharmacy -Lecturer and Tutor HUBS2209 Human Molecular Science -Course coordinator and lecturer HUBS2207 Human Metabolic and Nutritional Biochemistry- Lecturer and tutor HUBS3403 Neuroscience- Lecturer HUBS3409 Projects in Biomedical Science- Review of literature projects

Administrative Expertise
2011-2012: School of Biomedical Sciences and Pharmacy Executive Committee, University of Newcastle 2011-2012:School of Biomedical Sciences and Pharmacy Research Committee, University of Newcastle

Collaborations
Current collaborators: - Dr. Teodoro Bottiglieri, Baylor University Medical Center Institute of Metabolic Disease in Dallas, Texas, USA - Dr. Brian Wadzinski, Vanderbilt University, TN, USA. - Dr. Russell Nicholls, Columbia University, NY, USA - Drs. Sarah Commerford and Robert Hammer, UT Southwestern, Dallas, TX, USA - Dr. Charles L White III, UT Southwestern, Dallas, TX, USA - Dr. Egon Ogris, University of Vienna, Austria

Qualifications

  • Doctor of Philosophy, Louis Pasteur University - Strasbourg

Keywords

  • Alzheimer's disease
  • Biochemistry
  • Cell adhesion
  • Cell biology
  • Cell transformation
  • Folate metabolism
  • Medical biochemistry
  • Neuroscience
  • PP2A
  • Signal transduction

Languages

  • French (Fluent)

Fields of Research

Code Description Percentage
060199 Biochemistry and Cell Biology not elsewhere classified 35
060699 Physiology not elsewhere classified 15
110999 Neurosciences not elsewhere classified 50

Professional Experience

UON Appointment

Title Organisation / Department
Associate Professor University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia

Academic appointment

Dates Title Organisation / Department
1/01/2010 -  Membership - Australian Neuroscience Society Australian Neuroscience Society (ANS)
Australia
1/01/2006 - 31/12/2015 Editorial Board - Journal of Neuropathology and Experimental Neurology Journal of Neuropathology and Experimental Neurology
Australia
1/01/2004 -  Membership - Society for Neuroscience Society for Neuroscience
United States
1/01/2003 -  Membership - Society for Microbiology Society for Microbiology
Australia
1/01/1996 -  Membership - American Society for Cell Biology American Society for Cell Biology
United States
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Chapter (1 outputs)

Year Citation Altmetrics Link
2008 Sontag JM, Sontag E, 'PP2A: Multitasking and making decisions in cell growth', Protein Research Progress, Nova Science Publishers, Hauppauge, New York, United States of America 17-61 (2008) [B1]

Journal article (41 outputs)

Year Citation Altmetrics Link
2014 Sontag J, Sontag E, 'Protein phosphatase 2A dysfunction in Alzheimer¿s disease', Frontiers in Molecular Neuroscience, 7 1 (2014) [C1]
DOI 10.3389/fnmol.2014.00016
Citations Scopus - 9Web of Science - 10
2014 Sontag J-M, Wasek B, Taleski G, Smith J, Arning E, Sontag E, Bottiglieri T, 'Altered protein phosphatase 2A methylation and Tau phosphorylation in the young and aged brain of methylenetetrahydrofolate reductase (MTHFR) deficient mice', Frontiers in Aging Neuroscience, 6 (2014) [C1]

Common functional polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, a key enzyme in folate and homocysteine metabolism, influence risk for a variety of comple... [more]

Common functional polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, a key enzyme in folate and homocysteine metabolism, influence risk for a variety of complex disorders, including developmental, vascular, and neurological diseases. MTHFR deficiency is associated with elevation of homocysteine levels and alterations in the methylation cycle. Here, using young and aged Mthfr knockout mouse models, we show that mild MTHFR deficiency can lead to brain-region specific impairment of the methylation of Ser/Thr protein phosphatase 2A (PP2A). Relative to wild-type controls, decreased expression levels of PP2A and leucine carboxyl methyltransferase (LCMT1) were primarily observed in the hippocampus and cerebellum, and to a lesser extent in the cortex of young null Mthfr-/-and aged heterozygous Mthfr+/- mice. A marked down regulation of LCMT1 correlated with the loss of PP2A/Ba holoenzymes. Dietary folate deficiency significantly decreased LCMT1, methylated PP2A and PP2A/Ba levels in all brain regions examined from aged Mthfr+/+ mice, and further exacerbated the regional effects of MTHFR deficiency in aged Mthfr+/-mice. In turn, the down regulation of PP2A/Ba was associated with enhanced phosphorylation of Tau, a neuropathological hallmark of Alzheimer's disease (AD). Our findings identify hypomethylation of PP2A enzymes, which are major CNS phosphatases, as a novel mechanism by which MTHFR deficiency and Mthfr gene-diet interactions could lead to disruption of neuronal homeostasis, and increase the risk for a variety of neuropsychiatric disorders, including age-related diseases like sporadic AD. © 2014 Sontag, Wasek, Taleski, Smith, Arning, Sontag and Bottiglieri.

DOI 10.3389/fnagi.2014.00214
Citations Scopus - 1
2014 Sontag J-M, Sontag E, Tesone-Coelho C, Takemori H, Zwiller J, Dietrich J-B, 'Cocaine Regulates the Salt-Inducible Kinase (SIK1) by Inducing Protein Phosphatase-2A Expression in Rat Brain', Journal of Drug and Alcohol Research, 3 1-7 (2014) [C1]
DOI 10.4303/jdar/235854
2013 Sontag J-M, Nunbhakdi-Craig V, Sontag E, 'Leucine carboxyl methyltransferase 1 (LCMT1)-dependent methylation regulates the association of protein phosphatase 2A and Tau protein with plasma membrane microdomains in neuroblastoma cells', Journal of Biological Chemistry, 288 27396-27405 (2013) [C1]

Down-regulation of protein phosphatase 2A (PP2A) methylation occurs in Alzheimer disease (AD). However, the regulation of PP2A methylation remains poorly understood. We have repor... [more]

Down-regulation of protein phosphatase 2A (PP2A) methylation occurs in Alzheimer disease (AD). However, the regulation of PP2A methylation remains poorly understood. We have reported that altered leucine carboxyl methyltransferase (LCMT1)-dependent PP2A methylation is associated with down-regulation of PP2A holoenzymes containing the Ba subunit (PP2A/Ba) and subsequent accumulation of phosphorylated Tau in N2a cells, in vivo and in AD. Here, we show that pools of LCMT1, methylated PP2A, and PP2A/Ba are co-enriched in cholesterol-rich plasma membrane microdomains/rafts purified from N2a cells. In contrast, demethylated PP2A is preferentially distributed in non-rafts wherein small amounts of the PP2A methylesterase PME-1 are exclusively present. A methylation-incompetent PP2A mutant is excluded from rafts. Enhanced methylation of PP2A promotes the association of PP2A and Tau with the plasma membrane. Altered PP2A methylation following expression of a catalytically inactive LCMT1 mutant, knockdown of LCMT1, or alterations in one-carbon metabolism all result in a loss of plasma membrane-associated PP2A and Tau in N2a cells. This correlates with accumulation of soluble phosphorylated Tau, a hallmark of AD and other tauopathies. Thus, our findings reveal a distinct compartmentalization of PP2A and PP2A regulatory enzymes in plasma membrane microdomains and identify a novel methylation-dependent mechanism involved in modulating the targeting of PP2A, and its substrate Tau, to the plasma membrane. We propose that alterations in the membrane localization of PP2A and Tau following down-regulation of LCMT1 may lead to PP2A and Tau dysfunction in AD. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.

DOI 10.1074/jbc.M113.490102
Citations Scopus - 2Web of Science - 3
2012 Sontag J-M, Nunbhakdi-Craig V, White CLIII, Halpain S, Sontag EF, 'The protein phosphatase PP2A/B alpha binds to the microtubule-associated proteins tau and MAP2 at a motif also recognized by the kinase fyn: Implications for tauthopathies', Journal of Biological Chemistry, 287 14984-14993 (2012) [C1]
Citations Scopus - 18Web of Science - 16
2012 Bottiglieri T, Arning E, Wasek B, Nunbhakdi-Craig V, Sontag J-M, Sontag EF, 'Acute administration of L-dopa induces changes in methylation metabolites, reduced protein phosphatase 2A methylation, and hyperphosphorylation of Tau protein in mouse brain', Journal of Neuroscience, 32 9173-9181 (2012) [C1]
Citations Scopus - 11Web of Science - 10
2010 Sontag J-M, Nunbhakdi-Craig V, Mitterhuber M, Ogris E, Sontag EF, 'Regulation of protein phosphatase 2A methylation by LCMT1 and PME-1 plays a critical role in differentiation of neuroblastoma cells', Journal of Neurochemistry, 115 1455-1465 (2010) [C1]
DOI 10.1111/j.1471-4159.2010.07049.x
Citations Scopus - 14Web of Science - 14
2008 Sontag JM, Nunbhakdi-Craig V, Montgomery L, Arning E, Bottiglier T, Sontag E, 'Folate deficiency induces in vitro and mouse brain region-specific downregulation of leucine carboxyl methyltransferase-1 and protein phosphatase 2A B(alpha) subunit expression that correlate with enhanced tau phosphorylation', The Journal of Neuroscience, 28 1147-1148 (2008) [C1]
DOI 10.1523/JNEUROSCI.2816-08.2008
Citations Scopus - 32Web of Science - 32
2007 Nunbhakdi-Craig V, Schuechner S, Sontag JM, Montgomery L, Pallas DC, Juno C, et al., 'Expression of protein phosphatase 2A mutants and silencing of the regulatory Balpha subunit induce a selective loss of acetylated and detyrosinated microtubules', Journal of Neurochemistry, 101 959-971 (2007) [C1]
DOI 10.1111/j.1471-4159.2007.04503.x
2007 Sontag E, Nunbhakdi-Craig V, Sontag JM, Diaz-Arrastia R, Ogris E, Dayal S, et al., 'Protein phosphatase 2A methyltransferase links homocysteine metabolism with tau and amyloid precursor protein regulation', The Journal of Neuroscience, 27 2751-2759 (2007) [C1]
DOI 10.1523/JNEUROSCI.3316-06.2007
2006 Sontag JM, Sontag E, 'Regulation of cell adhesion by PP2A and SV40 small tumor antigen: an important link to cell transformation', Cellular and Molecular Life Sciences, 63 2979-2991 (2006) [C1]
DOI 10.1007/s00018-006-6300-7
2006 Procaccio V, Salazar G, Ono S, Styers ML, Gearing M, Davila A, et al., 'A mutation of beta -actin that alters depolymerization dynamics is associated with autosomal dominant developmental malformations, deafness, and dystonia.', American Journal of Human Genetics, 78 947-960 (2006) [C1]
DOI 10.1086/504271
2004 Sontag E, Luangpirom A, Christa H, Mudrak I, Ogris E, Speciale S, White C, 'Altered Expression Levels of the Protein Phosphatase 2A AB[alpha]C Enzyme Are Associated with Alzheimer Disease Pathology', Journal of Neuropathology and Experimental Neurology, 63 287-301 (2004) [C1]
2004 Sontag E, Hladik C, Montgomery L, Luangpirom A, Mudrak I, Ogris E, White C, 'Downregulation of protein phosphatase 2A carboxyl methylation and methyltransferase may contribute to Alzheimer's disease pathogenesis.', Journal of Neuropathology and Experimental Neurology, 63 1080-1091 (2004) [C1]
2003 Bigio EH, Reisch JS, White CL, Satumtira S, Sontag E, Bonte FJ, 'Synapse loss may be a minor contributor to decreased regional cerebral blood flow in Alzheimer disease', Dement.Geriatr.Cogn Disord., 15 72-78 (2003) [C1]
2003 Nunbhakdi-Craig V, Craig L, Machleidt T, Sontag E, 'Simian Virus 40 Small Tumor Antigen Induces Deregulation of the actin cytoskeleton and tight junctions in kidney epithelial cells', Journal of Virology, 77 2807-2818 (2003) [C1]
DOI 10.1128/JVI.77.5.2807-2818.2003
2003 Wang P-Y, Liu P, Weng J, Sontag E, Anderson RGW, 'A cholesterol-regulated PP2A/HePTP complex with dual specificty ERK1/2 phosphatase activity', The EMBO Journal, 22 2658-2667 (2003) [C1]
DOI 10.1093/emboj/cdg255
2002 Bigio EH, Hynan LS, Sontag E, Satumtira S, White CL, 'Synapse loss is greater in presenile than senile onset Alzheimer disease: implications for the cognitive reserve hypothesis', Neuropathol.Appl.Neurobiol., 28 218-227 (2002)
2002 Nunbhakdi-Craig V, Machleidt T, Ogris E, Bellotto D, White CL, Sontag E, 'Protein phosphatase 2A associates with and regulates atypical PKC and the epithelial tight junction complex', jcb, 158 967-978 (2002)
2001 Lipton AM, Cullum CM, Satumtira S, Sontag E, Hynan LS, White CL, Bigio EH, 'Contribution of asymmetric synapse loss to lateralizing clinical deficits in frontotemporal dementias', Arch.Neurol., 58 1233-1239 (2001)
2001 Eidenmuller J, Fath T, Maas T, Pool M, Sontag E, Brandt R, 'Phosphorylation-mimicking glutamate clusters in the proline-rich region are sufficient to simulate the functional deficiencies of hyperphosphorylated tau protein', Biochem.J., 357 759-767 (2001)
2001 Sontag E, 'Protein phosphatase 2A: the Trojan Horse of cellular signaling', Cell Signal., 13 7-16 (2001)
2001 Bigio EH, Vono MB, Satumtira S, Adamson J, Sontag E, Hynan LS, et al., 'Cortical synapse loss in progressive supranuclear palsy', J.Neuropathol.Exp.Neurol., 60 403-410 (2001)
2000 Eidenmuller J, Fath T, Hellwig A, Reed J, Sontag E, Brandt R, 'Structural and Functional Implications of Tau Hyperphosphorylation: Information from Phosphorylation-Mimicking Mutated Tau Proteins', Biochemistry, 39 13166-13175 (2000)
2000 Goedert M, Satumtira S, Jakes R, Smith MJ, Kamibayashi C, White CL, Sontag E, 'Reduced binding of protein phosphatase 2A to tau protein with frontotemporal dementia and parkinsonism linked to chromosome 17 mutations', J.Neurochem., 75 2155-2162 (2000)
2000 Garcia A, Cereghini S, Sontag E, 'Protein phosphatase 2A and phosphatidylinositol 3-kinase regulate the activity of Sp1-responsive promoters', JBC, 275 9385-9389 (2000)
2000 Garcia A, Cayla X, Sontag E, 'Protein phosphatase 2A: a definite player in viral and parasitic regulation', Microbes.Infect., 2 401-407 (2000)
1999 Sontag E, Nunbhakdi-Craig V, Lee G, Brandt R, Kamibayashi C, Kuret J, et al., 'Molecular Interactions among Protein Phosphatase 2A, Tau, and Microtubules. Implications for the regulation of tau phosphorylation and the development of tauopathies', JBC, 274 25490-25498 (1999)
1997 Sontag E, Sontag JM, Garcia A, 'Protein phosphatase 2A is a critical regulator of protein kinase C zeta signaling targeted by SV40 small t to promote cell growth and NF-kappaB activation', embo, 16 5662-5671 (1997)
1996 Sontag E, Nunbhakdi-Craig V, Lee G, Bloom GS, Mumby MC, 'Regulation of the phosphorylation state and microtubule-binding activity of Tau by protein phosphatase 2A', Neuron, 17 1201-1207 (1996)
1995 Sontag E, Nunbhakdi-Craig V, Bloom GS, Mumby MC, 'A novel pool of protein phosphatase 2A is associated with microtubules and is regulated during the cell cycle.', jcb, 128 1131-1144 (1995)
1994 Frost JA, Alberts AS, Sontag E, Guan K, Mumby MC, Feramisco JR, 'Simian virus 40 small t antigen cooperates with mitogen-activated kinases to stimulate AP-1 activity.', Mol.Cell Biol., 14 6244-6252 (1994)
1993 Sontag E, Fedorov S, Kamibayashi C, Robbins D, Cobb M, Mumby M, 'The interaction of SV40 small tumor antigen with protein phosphatase 2A stimulates the map kinase pathway and induces cell proliferation', Cell, 75 887-897 (1993)
1993 Helle KB, Marley PD, Angeletti RH, Aunis D, Galindo E, Small DH, Livett BG, 'Chromogranin A: secretion of processed products from the stimulated retrogradely perfused bovine adrenal gland', J.Neuroendocrinol., 5 413-420 (1993)
1993 Cetin Y, Aunis D, Bader MF, Galindo E, Jorns A, Bargsten G, Grube D, 'Chromostatin, a chromogranin A-derived bioactive peptide, is present in human pancreatic insulin (beta) cells', Proc.Natl.Acad.Sci.U.S.A, 90 2360-2364 (1993)
1993 Aardal S, Galindo E, Aunis D, Helle KB, 'Human chromostatin inhibits endothelin-1-induced contractures in human blood vessels', Regul.Pept., 47 25-32 (1993)
1992 Galindo E, Mendez M, Calvo S, Gonzalez-Garcia C, Cena V, Hubert P, et al., 'Chromostatin receptors control calcium channel activity in adrenal chromaffin cells', J.Biol.Chem., 267 407-412 (1992)
1992 Galindo E, Zwiller J, Bader MF, Aunis D, 'Chromostatin inhibits catecholamine secretion in adrenal chromaffin cells by activating a protein phosphatase', Proc.Natl.Acad.Sci.U.S.A, 89 7398-7402 (1992)
1991 Galindo E, Bader MF, Aunis D, 'Regulation of chromogranin a and chromogranin B (secretogranin I) synthesis in bovine cultured chromaffin cells', J.Neuroendocrinol., 3 669-677 (1991)
DOI 10.1111/j.1365-2826.1991.tb00332.x
1991 Anouar Y, Monti M, Galindo E, Benie T, Aunis D, Duval J, 'Regulatory Effects of Estrogens on the Pituitary Content of Secretogranin II and Chromogranin A', J.Neuroendocrinol., 3 233-235 (1991)
DOI 10.1111/j.1365-2826.1991.tb00269.x
1991 Galindo E, Rill A, Bader MF, Aunis D, 'Chromostatin, a 20-amino acid peptide derived from chromogranin A, inhibits chromaffin cell secretion', Proc.Natl.Acad.Sci.U.S.A, 88 1426-1430 (1991)
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Conference (22 outputs)

Year Citation Altmetrics Link
2014 Sontag E, 'Alterations in PP2A and tau in mouse models of MTHFR deficiency', -, UNSW, Sydney, Australia (2014) [E3]
2014 Sontag EFG, Hoffman A, Sontag JM, Bottiglieri T, 'Signal transduction by PP2A: Regulating the regulator.', -, Canberra (2014) [E3]
2014 Sontag JM, Wasek B, Taleski T, Smith J, Arning E, Sontag E, Bottiglieri T, 'Methylation of protein phosphatase 2A and phosphorylation of Tau protein in brain tissue from methylenetetrahydrofolate reductase deficient mice', -, Steamboat Springs, Colorado (2014) [E3]
2013 Sontag JM, Arning E, Numbhakdi-Craig V, Wasek B, Bottiglieri T, Sontag E, 'Regulation of PP2A methylation by genetic/drug/dietary interactions ¿ Implication for the treatment of neurodegenerative disorders', -, Melbourne, Australia (2013) [E3]
2013 Sontag EFG, 'Regional Effects of Acute L-DOPA Administration on Monoamines, Gamma-aminobutyric Acid and Acetylcholine Levels in the Mouse Brain', -, Florence, Italy (2013) [E3]
2013 Ahmed A, De Bock C, Zouikr I, Sontag E, Hondermarck H, Thorne R, 'FAT1 cadherin engages the hippo signalling pathway to mediate effects during SH-SY5Y cell differentiation', -, Perth, WA (2013)
2013 Ahmed AF, De Bock CE, Sontag E, Hondermarck H, Thorne RF, 'The functional role of Fat1 cadherin in the differentiation and proliferation of SH-SY5Y neuroblastoma cells', -, Pokolbin, NSW, Australia (2013) [E3]
Co-authors Hubert Hondermarck, Rick Thorne
2013 Sontag E, Sontag JM, Bottiglieri T, Arancio O, Nichollls R, 'Significance of protein phosphatase 2A in Alzheimer¿s disease', 7th Alzheimer's & Parkinson's Disease Symposium, Queensland Brain Institute (QBI), The University of Queensland, Australia (2013) [E3]
2013 Nicholls RE, Sontag JM, Zhang H, Staniszewski A, Woodruff CM, Yim M, et al., 'The role of PP2A methylation in beta-amyloid sensitivity and resistance', The 11th International Conference on Alzheimer¿s and Parkinson¿s Diseases, Florence, Italy (2013) [E3]
2012 Nicholls RE, Sontag J-M, Zhang H, Staniszewski A, Woodruff CM, Yim M, et al., 'The role of PP2A methylation in beta-amyliod sensitivity and resistance', Neuroscience 2012. Abstracts, New Orleans (2012) [E3]
2012 Sontag J-M, Nunbhakdi-Craig V, Bottiglieri T, Sontag EF, 'Regulation of PP2A methylation - Implications for neurogenerative disorders', Phosphates in Human Disease. Meeting Programme & Abstract Book, Melbourne, Vic (2012) [E3]
2012 Sontag EF, Sontag J-M, 'New insights into the regulation and role of PP2A methylation in Alzheimer disease', 2012 FASEB Science Research Conferences. Protein Phosphates, Snowmass, CO (2012) [E3]
2012 Arning E, Nunbhakdi-Craig V, Wasek B, Bottiglieri T, Sontag EF, Sontag J-M, 'Regulation of PP2A methylation by genetic/drug/dietary interactions - Implications for the treatment of neurodegenerative disorders', 2012 FASEB Science Research Conferences. Protein Phosphates, Snowmass, CO (2012) [E3]
2011 Wasek B, Erland A, Sontag J-M, Sontag EF, Bottiglieri T, 'The effect of microwave irradiation on methylation metabolites in folate deficient mouse brain tissue', Abstracts. 8th International Conference on Homocysteine Metabolism, Lisboa, Portugal (2011) [E3]
2011 Arning E, Wasek B, Williams M, Sontag EF, Bottiglieri T, 'L-dopa treatment reduces plasma concentrations of pyridoxal phosphate (vitamin b6) and decreases brain serotonin metabolism in the mouse: Implications for vitamin b6 dependent enzymes', Abstracts. The 10th International Conference on Alzheimer's and Parkinson's Diseases, Barcelona, Spain (2011) [E3]
2011 Sontag J-M, Nunbhakdi-Craig V, Sontag EF, 'Protein phosphatase 2A methylation plays a critical role in neurite outgrowth', Oral abstracts. Australian Neuroscience Society Annual Meeting, Auckland, NZ (2011) [E3]
2011 Sontag J-M, Nunbhakdi-Craig V, Sontag EF, 'A novel role for protein phosphatase 2A methylation in neuritogenesis', The 11th Hunter Meeting, Hunter Valley, NSW (2011) [E3]
2010 Sontag EF, Sontag J-M, Arning E, Nunbhakdi-Craig V, Wasek B, Bottiglieri T, 'Role of PP2A methylation in neurodegeneration', International Symposium on Protein Phosphorylation in Neurodegenerative Diseases: Abstracts, Valencia, Spain (2010) [E3]
2010 Sontag J-M, Nunbhakdi-Craig V, Sontag EF, 'Protein phosphatase 2A methylation plays a critical role in neurite outgrowth', Neuroscience 2010: Final Program, San Diego, CA (2010) [E3]
2009 Sontag EF, 'Role of PP2A methylation pathways in tau regulation', Alzheimer's and Dementia, Vienna, Austria (2009) [E3]
DOI 10.1016/j.jalz.2009.05.250
2009 Bottiglieri T, Arning E, Wasek B, Sontag J-M, Sontag EF, 'L-dopa induces changes in methylation metabolites, PP2A demethylation and hyper-phosphorylation of Tau protein in mouse brain', 7th International Conference on Homocysteine Metabolism: Abstract Book, Prague, Czech Republic (2009) [E3]
2008 Mao QW, Hatanpaa KJ, Sontag E, Hladik CL, Xia HB, White CL, 'Establishment of a stable progranulin deficient cell line: a model of frontotemporal dementia with ubiquitin-positive inclusions', Journal of Neuropathology and Experimental Neurology, San Diego, California, USA (2008) [E3]
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Grants and Funding

Summary

Number of grants 8
Total funding $609,277

Click on a grant title below to expand the full details for that specific grant.


20151 grants / $700

International Society for Neurochemistry - Biennial meeting and Advanced School, Fizroy Island and Cairns AUS, 19-27 August 2015$700

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Associate Professor Estelle Sontag
Scheme Travel Grant
Role Lead
Funding Start 2015
Funding Finish 2015
GNo G1500686
Type Of Funding Internal
Category INTE
UON Y

20143 grants / $93,014

JuLI Stage $71,674

Funding body: NHMRC (National Health & Medical Research Council)

Can dietary folate supplementation slow down Alzheimer’s Disease?$20,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Jean-Marie Sontag, Associate Professor Estelle Sontag
Scheme Project Grant
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1401436
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

ComBio2014, Canberra Australia, 28 September - 2 October 2014$1,340

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Associate Professor Estelle Sontag
Scheme Travel Grant
Role Lead
Funding Start 2014
Funding Finish 2014
GNo G1400731
Type Of Funding Internal
Category INTE
UON Y

20132 grants / $59,596

20121 grants / $1,500

2012 FASEB Science Research Conferences - Protein phosphatases, Snowmass Colorado, 15 - 20 July 2012$1,500

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Associate Professor Estelle Sontag
Scheme Travel Grant
Role Lead
Funding Start 2012
Funding Finish 2012
GNo G1200536
Type Of Funding Internal
Category INTE
UON Y

20111 grants / $454,467

Protein Phosphatase 2A methylation: Regulation and functional significance for tauopathies$454,467

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Associate Professor Estelle Sontag, Doctor Jean-Marie Sontag
Scheme Project Grant
Role Lead
Funding Start 2011
Funding Finish 2011
GNo G1000241
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y
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Research Supervision

Number of supervisions

Completed0
Current2

Total current UON EFTSL

Masters0.8
PhD0.25

Current Supervision

Commenced Research Title / Program / Supervisor Type
2015 The Protein Phosphatase 2A in Alzheimer's Disease Pathogenesis
Medical Science, Faculty of Health and Medicine
Principal Supervisor
2011 Role of FAT1 Cadherin in Neuronal Differentiation
Medical Science, Faculty of Health and Medicine
Co-Supervisor
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Associate Professor Estelle Sontag

Position

Associate Professor
(02) 4921 5018
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

Focus area

Medical Biochemistry

Contact Details

Email estelle.sontag@newcastle.edu.au
Phone (02) 4921 6239
Fax (02) 4921 7903

Office

Room LS3-34
Building Life Sciences
Location Callaghan
University Drive
Callaghan, NSW 2308
Australia
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