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Professor Eileen McLaughlin

Pro Vice-Chancellor (Interim)

Office PVC - Science and Information Technology (Biological Sciences)

A good egg

The mysteries of conception are this researcher's passion. As a young biologist, Professor Eileen McLaughlin produced her first test tube baby in 1983, just five years after Louise Brown was heralded as the world's first IVF birth.

Professor Eileen McLaughlin in the laboratory 

It was a case of 'right time, right place' for McLaughlin, who graduated from the University of Glasgow to research positions involving assisted reproduction at the universities of Birmingham and Bristol at a time when Britain was the international hot spot in this emerging field.

That experience was the foundation for what has become a distinguished research career in reproductive science. McLaughlin's work has been recognised with awards from the British Fertility Society and the Society for Reproductive Biology in Australia and has been published in esteemed medical journals including Cell and The Lancet.

Since joining the University's reproductive science group in 2001, a focus of McLaughlin's research has been the fertility prospects of older women.

She says her research has reinforced the theory that declining egg quality, rather than quantity, is the major hindrance to conception in women in their late 30s and older.

While science has not delivered a magic formula to improve the quality of mature eggs, McLaughlin is researching the way oocytes, or immature egg cells, are 'woken' to be released from the ovary. The aim is that better understanding this process could lead to new ways of harvesting or prolonging the life of good eggs.

"The attrition rate of eggs is very high," she says. "A female has about 1 million eggs at birth but by the time she is in her mid 30s she is down to about 20,000.  By the age of 40, she will have a few thousand," she says.

"She will only ovulate 400 eggs in her life, so the vast majority of them are wasted. The challenge is to find a way to a hold on to some of those good eggs longer."

McLaughlin's work has established that many chemicals used in everyday items such as glues, dyes and pesticides, are potentially toxic to eggs, which can further frustrate the efforts of older mothers to conceive.
Professor Eileen McLaughlin with a microscope
"There are increasing numbers of women in their 30s who are having difficulty producing a sufficient number of good eggs to conceive. The evidence suggests that this may be influenced by lifetime exposure, probably at very low levels, to environmental toxicants," she says.

Exposure to these chemicals is a consequence of living in the modern world and McLaughlin says little can be done to reduce women's susceptibility. But the research underpins the importance of her work in trying to extend the life of healthy oocytes and improve outcomes for couples trying to conceive later in life.

Professor Eileen McLaughlin researches in collaboration with the Hunter Medical Research Institute's (HMRI) Pregnancy and Reproduction Program.  HMRI is a partnership between the University, Hunter New England Local Health District and the community.

Visit the Centre for Reproductive Science website

Visit the HMRI website

Eileen McLaughlin in a laboratory

A good egg

Biologist Professor Eileen McLaughlin is looking into the mysteries of conception.

Read more

Career Summary

Biography

I undertook a PhD at the University of Bristol on the effects of cryopreservation on human gametes and embryos under the supervision of Dr Chris Ford. On completion of my PhD I moved to the Department of Biochemistry on a Wellcome Trust postdoctoral fellowship to work in the lab of Prof Len Hall where I identified genes involved in male fertility and characterised their role in fertilization. In 2000 I took up a position in the Pest Animal Control CRC in CSIRO Sustainable Ecosystems in Canberra where I worked on the development of virally vectored immunocontraception for rabbit control. In 2002 I was recruited to the University of Newcastle where I established my research group. Work in my lab focuses on the RNA binding proteins and their roles in spermatogenesis and folliculogenesis and proteins involved in meiosis. In addition we study cytokines that control the activation of primordial follicles in the mammalian ovary and ovotoxic xenobiotics which cause oocyte loss and early menopause. I have published in Cell Stem Cell, PNAS, Developmental Biology and Toxicological Sciences . We use a number of mouse models and a wide range of cell and molecular biology techniques to monitor cell signalling dynamics in primary culture, identify novel target proteins, functionally characterise translational repressors and activators and use structural modelling to design inhibitors of these interactions. We collaborate extensively through the ARC Centre of Excellence in Biotechnology and Development as well as with individual groups in the USA and Australia.

Research Expertise
My research in the field of testicular biology has focused on spermatogonial development with particular emphasis on the identification and characterization of key regulators of spermatogonial stem cell replication (HOW), microRNA in germ cells, stem cell maintenance (Musashi), and male germ cell differentiation (c-Kit) and sperm function (Fertilin) (see McIver et al 2012 Human Reproduction Update, Monk et al 2010 Cell Stem Cell, Monk et al PLoS One 2012, Siddall et al 2006 PNAS, Prahbu et al 2006 Reproduction, McLaughlin et al 2001 Molecular Human Reproduction). In addition we study cytokines that control the activation of primordial follicles in the mammalian ovary and ovotoxic xenobiotics which cause oocyte loss and early menopause ( see Sutherland et al 2012 J Cellular Physiology, Sobinoff et al 2012, 2011, 2010 Toxicological Sciences, Blackmore et al 2004 Biology of Reproduction, Holt et al 2006 Developmental Biology, Hutt et al 2006 Biology of Reproduction, McLaughlin & McIver Reproduction 2009). In addition my lab has contributed to cell and molecular research in human and animal assisted reproduction with an emphasis on the characterization of gene and protein expression and function in male and female gametogenesis, reproductive tracts, roles in fertilization and as contraceptive targets (McLaughlin et al 2001, Asquith et al 2004, 2005, Nixon et al 2007, 2009, McLaughlin et al 2010, Redgrove et al 2011, Walker et al 2011).

Teaching Expertise
Senior Lecturer, Tutor & Demonstrator in Cell and Molecular Biology, Biochemistry, Immunobiology and Biotechnology (1000,2000 and 3000level) Implementation first ever Web-based delivery of all Level 1000 courses via Blackboard. Overseeing implementation of on-line assessments, and simulated laboratory computer experiments. Implementation Turnitin anti-plagiarism and collusion educational software for BIOL1000 cohort (2004). Awarded Graduate Certificate in Tertiary Teaching University of Newcastle 2006

Administrative Expertise
University Expertise Animal Ethics Committee Member Deputy Head of School of Environmental & Life Sciences Institutional Biosafety Committee Member ERA Cluster 8 committee member Animal Ethics Review Committee Member Faculty of Science Research and Research Training Committee Member Manager and Instructor-in-charge of Imaging Suite, Life Sciences Building (2001 - present) Chair of School Committee Review of Induction Materials for Honours students (2002 - 3) School Representative for Faculty of Science & IT International Committee (2004 - 2005) Biological Sciences Representative for School Research Higher Degree Progress Committee (2003 - present) Coordinator Level 1000 Biology - 500 students and 50 staff and Level 2000 Biology - 100 students and 10 staff Professional Activities Reviewer Grant Giving Bodies: NHMRC GRP member, Medical Research Council UK, the Biotechnology & Biological Sciences Research Council UK, and the Wellcome Trust. I also review for a number of specialist Reproduction journals. Positions in Learned Societies: President elect of Society for Reproductive Biology, Chairman of the British Andrology Society (1997-2000) and a Director of the Journal of Reproduction & Fertility (Ltd.). Committee member: British Fertility Society Association of Clinical Embryologists, Society for Reproductive Biology and the Society for Low Temperature Biology. Editor: multiple peer reviewed clinical guidelines and am an adviser to the United States of America Congress, Office of Technology Assessment and the UK Government Department of Health and the Human Fertilization and Embryology Authority.

Collaborations
Collaborators include: Dr Shaun Roman, Dr Brett Nixon, Prof John Aitken, Prof Adam McCluskey (University of Newcastle) Prof Keith Jones, Dr Janet Holt and Dr Julie Merriman Jones (University of Newcastle) Dr Gary Hime (University of Melbourne) and Prof Minx Fuller (Standford University) Prof Kate Loveland & Prof Moira O'Bryan (Monash University) Dr Darryl Russell and Dr Rebecca Robker (University of Adelaide) Prof Peter Koopman and Dr Jo Bowles (University of Queensland) Prof Ken Beagley (QUT) & Dr C Wira (Dartmouth University)

Qualifications

  • PhD, University of Bristol
  • Bachelor of Science (Honours), University of Glasgow - Scotland

Keywords

  • Biochemistry
  • Biology
  • Biotechnology
  • Immunobiology
  • Ovarian Biology
  • Reproductive Sciences
  • Spermatogonial Stem Cells

Fields of Research

Code Description Percentage
060199 Biochemistry and Cell Biology not elsewhere classified 55
060699 Physiology not elsewhere classified 30
111499 Paediatrics and Reproductive Medicine not elsewhere classified 15

Professional Experience

UON Appointment

Title Organisation / Department
Professor University of Newcastle
School of Environmental and Life Sciences
Australia

Academic appointment

Dates Title Organisation / Department
1/04/2010 -  Professor University of Newcastle
School of Environmental and Life Sciences
Australia
1/07/2008 - 1/04/2010 Associate Professor University of Newcastle
School of Environmental and Life Sciences
Australia
1/01/2005 - 1/06/2008 Senior Lecturer University of Newcastle
School of Environmental and Life Sciences
Australia
1/11/2001 - 1/12/2004 Lecturer University of Newcastle
School of Environmental and Life Sciences
Australia

Membership

Dates Title Organisation / Department
Programme Committee Member Society for Reproductive Biology
Australia

Invitations

Participant

Year Title / Rationale
2005 Primordial follicle activation and development
Organisation: University of Adelaide
Edit

Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Chapter (7 outputs)

Year Citation Altmetrics Link
2013 Sutherland JM, McLaughlin EA, Hime GR, Siddall NA, 'The Musashi family of RNA binding proteins: master regulators of multiple stem cell populations.', Transcriptional and Translational Regulation of Stem Cells, Springer, Dordrecht 233-245 (2013) [B1]
DOI 10.1007/978-94-007-6621-1_13
Citations Scopus - 4Web of Science - 3
2012 Sobinoff AP, Bernstein IR, McLaughlin EA, 'All your eggs in one basket: Mechanisms of xenobiotic induced female reproductive senescence', Senescence, InTech Press, Rijeka 559-584 (2012) [B1]
2010 McLaughlin EA, Sobinoff AP, 'Contraception targets in mammalian ovarian development', Fertility Control, Springer, Berlin 45-66 (2010) [B1]
Citations Scopus - 3
2009 McLaughlin EA, Pacey AA, 'Cryopreservation and storage of spermatozoa', Textbook of Assisted Reproductive Technologies: Laboratory and Clinical Perspectives, Informa Healthcare, London 311-321 (2009) [B2]
2004 McLaughlin EA, 'Cryopreservation and storage of spermatozoa', Textbook of Assisted Reproductive Techniques: Laboratory and Clinical Perspectives, Taylor & Francis, London 297-307 (2004) [B2]
2002 McLaughlin EA, Holland M, 'Developing Immunocontraceptives', Assisted Reproductive Technology: Accomplishments and New Horizons, Cambridge University Press, Cambridge, UK 355-365 (2002) [B1]
2001 McLaughlin EA, 'Cryopreservation & storage of sperm', , Martin Dunitz, London, 261-272 (2001) [B1]
Show 4 more chapters

Journal article (115 outputs)

Year Citation Altmetrics Link
2015 Sobinoff AP, Dando SJ, Redgrove KA, Sutherland JM, Stanger SJ, Armitage CW, et al., 'Chlamydia muridarum infection-induced destruction of male germ cells and sertoli cells is partially prevented by Chlamydia major outer membrane protein-specific immune CD4 cells.', Biol Reprod, 92 27 (2015)
DOI 10.1095/biolreprod.114.124180
2015 Sutherland JM, Sobinoff AP, Gunter KM, Fraser BA, Pye V, Bernstein IR, et al., 'Knockout of RNA Binding Protein MSI2 Impairs Follicle Development in the Mouse Ovary: Characterization of MSI1 and MSI2 during Folliculogenesis.', Biomolecules, 5 1228-1244 (2015)
DOI 10.3390/biom5031228
2015 Sutherland JM, Siddall NA, Hime GR, McLaughlin EA, 'RNA binding proteins in spermatogenesis: an in depth focus on the Musashi family.', Asian J Androl, 17 529-536 (2015)
DOI 10.4103/1008-682X.151397
2015 Nixon B, Bromfield EG, Dun MD, Redgrove KA, McLaughlin EA, Aitken RJ, 'The role of the molecular chaperone heat shock protein A2 (HSPA2) in regulating human sperm-egg recognition.', Asian J Androl, 17 568-573 (2015)
DOI 10.4103/1008-682X.151395
Co-authors Matt Dun, Brett Nixon, John Aitken
2015 Sutherland JM, Sobinoff AP, Fraser BA, Redgrove KA, Davidson TL, Siddall NA, et al., 'RNA binding protein Musashi-1 directly targets Msi2 and Erh during early testis germ cell development and interacts with IPO5 upon translocation to the nucleus.', FASEB J, 29 2759-2768 (2015)
DOI 10.1096/fj.14-265868
2015 Reid AT, Anderson AL, Roman SD, McLaughlin EA, McCluskey A, Robinson PJ, et al., 'Glycogen synthase kinase 3 regulates acrosomal exocytosis in mouse spermatozoa via dynamin phosphorylation.', FASEB J, 29 2872-2882 (2015)
DOI 10.1096/fj.14-265553
Co-authors Adam Mccluskey, Shaun Roman, Brett Nixon, John Aitken
2015 Nixon B, Stanger SJ, Mihalas BP, Reilly JN, Anderson AL, Dun MD, et al., 'Next Generation Sequencing Analysis Reveals Segmental Patterns of microRNA Expression in Mouse Epididymal Epithelial Cells.', PloS one, 10 e0135605 (2015)
Co-authors Brett Nixon, Matt Dun
2014 Robker RL, Watson LN, Robertson SA, Dunning KR, McLaughlin EA, Russell DL, 'Identification of sites of STAT3 action in the female reproductive tract through conditional gene deletion', PLoS ONE, 9 (2014) [C1]

The STAT3 transcription factor is a pleiotropic transducer of signalling by hormones, growth factors and cytokines that has been identified in the female reproductive tract from o... [more]

The STAT3 transcription factor is a pleiotropic transducer of signalling by hormones, growth factors and cytokines that has been identified in the female reproductive tract from oocytes and granulosa cells of the ovary to uterine epithelial and stromal cells. In the present study we used transgenic models to investigate the importance of STAT3 for reproductive performance in these different tissues. The Cre-LoxP system was used to delete STAT3 in oocytes by crossing Stat3 fl/fl with Zp3-cre+ mice, or in ovarian granulosa cells and uterine stroma by crossing with Amhr2-Cre+ mice. Surprisingly, deletion of STAT3 in oocytes had no effect on fertility indicating that the abundance of STAT3 protein in maturing oocytes and fertilized zygotes is not essential to these developmental stages. In Stat3fl/fl;Amhr2-cre + females impaired fertility was observed through significantly fewer litters and smaller litter size. Ovulation rate, oocyte fertilization and development to blastocyst were unaffected in this line; however, poor recombination efficiency in granulosa cells had yielded no net change in STAT3 protein abundance. In contrast, uteri from these mice showed STAT3 protein depletion selectively from the stomal compartment. A significant reduction in number of viable fetuses on gestational day 18, increased fetal resorptions and disrupted placental morphology were evident causes of the reduced fertility. In conclusion, this study defines an important role for STAT3 in uterine stromal cells during embryo implantation and the development of a functional placenta. © 2014 Robker et al.

DOI 10.1371/journal.pone.0101182
2014 Redgrove KA, McLaughlin EA, 'The role of the immune response in chlamydia trachomatis infection of the male genital tract: A double-edged sword', Frontiers in Immunology, 5 1-22 (2014) [C1]
DOI 10.3389/fimmu.2014.00534
Citations Scopus - 2Web of Science - 1
2014 Camlin NJ, McLaughlin EA, Holt JE, 'Through the smoke: Use of in vivo and in vitro cigarette smoking models to elucidate its effect on female fertility', Toxicology and Applied Pharmacology, 281 266-275 (2014) [C1]

A finite number of oocytes are established within the mammalian ovary prior to birth to form a precious ovarian reserve. Damage to this limited pool of gametes by environmental fa... [more]

A finite number of oocytes are established within the mammalian ovary prior to birth to form a precious ovarian reserve. Damage to this limited pool of gametes by environmental factors such as cigarette smoke and its constituents therefore represents a significant risk to a woman's reproductive capacity. Although evidence from human studies to date implicates a detrimental effect of cigarette smoking on female fertility, these retrospective studies are limited and present conflicting results. In an effort to more clearly understand the effect of cigarette smoke, and its chemical constituents, on female fertility, a variety of in vivo and in vitro animal models have been developed. This article represents a systematic review of the literature regarding four of experimental model types: 1) direct exposure of ovarian cells and follicles to smoking constituents' in vitro, 2) direct exposure of whole ovarian tissue with smoking constituents in vitro, 3) whole body exposure of animals to smoking constituents and 4) whole body exposure of animals to cigarette smoke. We summarise key findings and highlight the strengths and weaknesses of each model system, and link these to the molecular mechanisms identified in smoke-induced fertility changes.

DOI 10.1016/j.taap.2014.10.010
Co-authors Janet Holt
2014 Holt JE, Pye V, Boon E, Stewart JL, Garcia-Higuera I, Moreno S, et al., 'The APC/C activator FZR1 is essential for meiotic prophase I in mice', DEVELOPMENT, 141 1354-U327 (2014) [C1]
DOI 10.1242/dev.104828
Citations Scopus - 1Web of Science - 1
Co-authors Janet Holt, Keith Jones
2014 Yun Y, Holt JE, Lane SIR, McLaughlin EA, Merriman JA, Jones KT, 'Reduced ability to recover from spindle disruption and loss of kinetochore spindle assembly checkpoint proteins in oocytes from aged mice', Cell Cycle, 13 1938-1947 (2014) [C1]

Currently, maternal aging in women, based on mouse models, is thought to raise oocyte aneuploidy rates, because chromosome cohesion deteriorates during prophase arrest, and Sgo2, ... [more]

Currently, maternal aging in women, based on mouse models, is thought to raise oocyte aneuploidy rates, because chromosome cohesion deteriorates during prophase arrest, and Sgo2, a protector of centromeric cohesion, is lost. Here we show that the most common mouse strain, C57Bl6/J, is resistant to maternal aging, showing little increase in aneuploidy or Sgo2 loss. Instead it demonstrates significant kinetochore-associated loss in the spindle assembly checkpoint protein Mad2 and phosphorylated Aurora C, which is involved in microtubule-kinetochore error correction. Their loss affects the fidelity of bivalent segregation but only when spindle organization is impaired during oocyte maturation. These findings have an impact clinically regarding the handling of human oocytes ex vivo during assisted reproductive techniques and suggest there is a genetic basis to aneuploidy susceptibility. © 2014 Landes Bioscience.

DOI 10.4161/cc.28897
Citations Scopus - 4Web of Science - 3
Co-authors Keith Jones, Janet Holt
2014 Trinh TN, McLaughlin EA, Gordon CP, McCluskey A, 'Hedgehog signalling pathway inhibitors as cancer suppressing agents', MedChemComm, 5 117-133 (2014) [C1]

The Hedgehog (Hh) signalling pathway plays a pivotal role in the spatial and temporal regulation of cell proliferation and differentiation. By controlling the correct maturation o... [more]

The Hedgehog (Hh) signalling pathway plays a pivotal role in the spatial and temporal regulation of cell proliferation and differentiation. By controlling the correct maturation of developing tissues and ensuring attainment of the correct size, position and the presence of fully functioning cellular structures, the Hh plays a pivotal role in development. Conversely aberrant Hh signalling is involved in Gorlin syndrome, basal cell carcinoma (the most common cancer in the world), and more than one third of all human medulloblastoma cases. In all of these cases, it is believed that deregulated Hh signalling leads to increased cell proliferation and tumour formation. Inhibition of the Hedgehog signalling pathway, is a recently validated anti-cancer drug target, with vismodegib (Erivedge¿), approved by the U.S. Food and Drug Administration for the treatment of adult basal cell carcinoma. In this perspective we outline the current state of Hh pathway inhibitors with a particular focus on potential limitations of upstream Hh pathway inhibition in relation to resistance mutations and crosstalk pathways. Together, these limitations indicate that inhibition of downstream components, specifically the Gli family of transcription factors, may represent a next generation approach to suppress tumours associated with aberrant Hh pathway signalling. © 2014 The Royal Society of Chemistry.

DOI 10.1039/c3md00334e
Citations Scopus - 8Web of Science - 5
Co-authors Adam Mccluskey
2014 Sahin Z, Szczepny A, Mclaughlin EA, Meistrich ML, Zhou W, Ustunel I, Loveland KL, 'Dynamic Hedgehog signalling pathway activity in germline stem cells', Andrology, 2 267-274 (2014) [C1]

Summary: Although the contribution of Hedgehog (Hh) signalling to stem cell development and oncogenesis is well recognised, its importance for spermatogonial stem cells (SSCs) has... [more]

Summary: Although the contribution of Hedgehog (Hh) signalling to stem cell development and oncogenesis is well recognised, its importance for spermatogonial stem cells (SSCs) has not been established. Here we interrogate adult rat SSCs using an established model in which only undifferentiated spermatogonial cells remain in the testis at 15 weeks following irradiation, and spermatogonial differentiation is induced within 4 weeks by gonadotrophin-releasing hormone antagonist (GnRH-ant) administration. Synthesis of Hh pathway components in untreated adult rat testes was compared with that in irradiated testes prior to and after GnRH-ant exposure using in situ hybridization. In adult testes with complete spermatogenesis, the Desert Hedgehog ligand transcript, Dhh, was detected in Sertoli cells, some spermatogonia and in spermatocytes by in situ hybridization. Spermatogenic cells were identified as sites of Hh signalling through detection of transcripts encoding the Hh receptor, Ptc2 transcripts and proteins for the key downstream target of Hh signalling, Gli1 and the Hh transcriptional activator, Gli2. Remarkably, the undifferentiated spermatogonia present in irradiated adult rat testes contained Dhh in addition to Ptc2, Gli1 and Gli2, revealing the potential for an autocrine Hh signalling loop to sustain undifferentiated spermatogonial cells. These transcripts became undetectable by in situ hybridization following GnRH-ant induction of spermatogonial differentiation, however, detection of Gli1 protein in spermatogonia in all groups indicates that Hh signalling is sustained. This is the first evidence of active Hh signalling in mammalian male germline stem cells, as has been documented for some cancer stem cells. © 2014 American Society of Andrology and European Academy of Andrology.

DOI 10.1111/j.2047-2927.2014.00187.x
2014 Sutherland JM, Fraser BA, Sobinoff AP, Pye VJ, Davidson TL, Siddall NA, et al., 'Developmental expression of Musashi-1 and Musashi-2 RNA-binding proteins during spermatogenesis: analysis of the deleterious effects of dysregulated expression.', Biol Reprod, 90 92 (2014) [C1]
DOI 10.1095/biolreprod.113.115261
Citations Scopus - 1Web of Science - 3
2014 Redgrove KA, McLaughlin EA, 'The Role of the Immune Response in Chlamydia trachomatis Infection of the Male Genital Tract: A Double-Edged Sword.', Front Immunol, 5 534 (2014)
DOI 10.3389/fimmu.2014.00534
2014 Sobinoff AP, Sutherland JM, Beckett EL, Stanger SJ, Johnson R, Jarnicki AG, et al., 'Damaging legacy: maternal cigarette smoking has long-term consequences for male offspring fertility.', Hum Reprod, 29 2719-2735 (2014) [C1]
DOI 10.1093/humrep/deu235
Citations Scopus - 2Web of Science - 3
Co-authors Adam Mccluskey, Philip Hansbro
2013 McIver SC, Roman SD, Nixon B, McLaughlin EA, Loveland KL, 'The rise of testicular germ cell tumours: The search for causes, risk factors and novel therapeutic targets [v1; ref status: Indexed, http://f1000r.es/md]', F1000 Research, 2 1-12 (2013) [C1]
DOI 10.12688/f1000research.2-55.v2
Co-authors Shaun Roman, Brett Nixon
2013 McIver SM, Roman SD, Nixon B, Loveland KL, McLaughlin EA, 'The rise of testicular germ cell tumours: the search for causes, risk factors and novel therapeutic targets', F1000Research, 2:55 (doi: 10.12688/f1000research.2-55.v1) 55-66 (2013)
Citations Scopus - 2
Co-authors Brett Nixon, Shaun Roman
2013 Merriman JA, Lane SIR, Holt JE, Jennings PC, Garcia-Higuera I, Moreno S, et al., 'Reduced Chromosome Cohesion Measured by Interkinetochore Distance Is Associated with Aneuploidy Even in Oocytes from Young Mice', Biology of Reproduction, 88 31-31 (2013) [C1]
DOI 10.1095/biolreprod.112.104786
Citations Scopus - 4Web of Science - 4
Co-authors Janet Holt, Keith Jones
2013 Sobinoff AP, Beckett EL, Jarnicki AG, Sutherland JM, McCluskey A, Hansbro PM, McLaughlin EA, 'Scrambled and fried: Cigarette smoke exposure causes antral follicle destruction and oocyte dysfunction through oxidative stress', TOXICOLOGY AND APPLIED PHARMACOLOGY, 271 156-167 (2013) [C1]
DOI 10.1016/j.taap.2013.05.009
Citations Scopus - 9Web of Science - 9
Co-authors Adam Mccluskey, Philip Hansbro
2013 Davies RG, Wagstaff KM, McLaughlin EA, Loveland KL, Jans DA, 'The BRCA1-binding protein BRAP2 can act as a cytoplasmic retention factor for nuclear and nuclear envelope-localizing testicular proteins', Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1833 3436-3444 (2013) [C1]
DOI 10.1016/j.bbamcr.2013.05.015
Citations Scopus - 2Web of Science - 2
2013 Sutherland JM, McLaughlin EA, Hime GR, Siddall NA, 'The Musashi family of RNA binding proteins: Master regulators of multiple stem cell populations', Advances in Experimental Medicine and Biology, 786 233-245 (2013)

In order to maintain their unlimited capacity to divide, stem cells require controlled temporal and spatial protein expression. The Musashi family of RNA-binding proteins have bee... [more]

In order to maintain their unlimited capacity to divide, stem cells require controlled temporal and spatial protein expression. The Musashi family of RNA-binding proteins have been shown to exhibit this necessary translational control through both repression and activation in order to regulate multiple stem cell populations. This chapter looks in depth at the initial discovery and characterisation of Musashi in the model organism Drosophila, and its subsequent emergence as a master regulator in a number of stem cell populations. Furthermore the unique roles for mammalian Musashi-1 and Musashi-2 in different stem cell types are correlated with the perceived diagnostic power of Musashi expression in specific stem cell derived oncologies. In particular the potential role for Musashi in the identification and treatment of human cancer is considered, with a focus on the role of Musashi-2 in leukaemia. Finally, the manipulation of Musashi expression is proposed as a potential avenue towards the targeted treatment of specific aggressive stem cell cancers. © 2013 Springer Science+Business Media Dordrecht.

DOI 10.1007/978-94-7-6621-1_13
2013 Loveland KL, McLaughlin EA, 'Hidden gems in the niche: a new approach to the study of spermatogonial stem cells', ASIAN JOURNAL OF ANDROLOGY, 15 214-215 (2013) [C3]
DOI 10.1038/aja.2012.150
2013 Redgrove KA, Anderson AL, McLaughlin EA, O'Bryan MK, Aitken RJ, Nixon B, 'Investigation of the mechanisms by which the molecular chaperone HSPA2 regulates the expression of sperm surface receptors involved in human spermoocyte recognition', MOLECULAR HUMAN REPRODUCTION, 19 120-135 (2013) [C1]
DOI 10.1093/molehr/gas064
Citations Scopus - 15Web of Science - 16
Co-authors John Aitken, Brett Nixon
2013 Sobinoff AP, Sutherland JM, Mclaughlin EA, 'Intracellular signalling during female gametogenesis', Molecular Human Reproduction, 19 265-278 (2013) [C1]

Female reproductive potential is dictated by the size of the primordial follicle pool and the correct regulation of oocyte maturation and activation-events essential for productio... [more]

Female reproductive potential is dictated by the size of the primordial follicle pool and the correct regulation of oocyte maturation and activation-events essential for production of viable offspring. Although a substantial body of work underpins our understanding of these processes, the molecular mechanisms of follicular and oocyte development are not fully understood. This review summarizes recent findings which have improved our conception of how folliculogenesis and oocyte competence are regulated, and discusses their implications for assisted reproductive techniques. We highlight evidence provided by genetically modified mouse models and in vitro studies which have refined our understanding of Pi3k/Akt and mTOR signalling in the oocyte and have discovered a role for Jak/Stat/Socs signalling in granulosa cells during primordial follicle activation. We also appraise a novel role for the metal ion zinc in the regulation of meiosis I and meiosis II progression through early meiosis inhibitor (Emi2) and Mos-Mapk signalling, and examine studies which expand our understanding of intracellular calcium signalling and extrinsic Plc¿ in stimulating oocyte activation. © The Author 2012. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved.

DOI 10.1093/molehr/gas065
Citations Scopus - 10Web of Science - 10
2013 O'Bryan MK, Clark BJ, McLaughlin EA, D'Sylva RJ, O'Donnell L, Wilce JA, et al., 'RBM5 Is a Male Germ Cell Splicing Factor and Is Required for Spermatid Differentiation and Male Fertility', PLOS GENETICS, 9 (2013) [C1]
DOI 10.1371/journal.pgen.1003628
Citations Scopus - 3Web of Science - 4
2013 Sominsky L, Sobinoff AP, Jobling MS, Pye V, McLaughlin EA, Hodgson DM, 'Immune regulation of ovarian development: programming by neonatal immune challenge.', Frontiers in Neuroscience, 7 100 (2013) [C1]
DOI 10.3389/fnins.2013.00100
Co-authors Deborah Hodgson
2013 McIver SC, Loveland KL, Roman SD, Nixon B, Kitazawa R, McLaughlin EA, 'The chemokine CXCL12 and its receptor CXCR4 are implicated in human seminoma metastasis', ANDROLOGY, 1 517-529 (2013) [C1]
DOI 10.1111/j.2047-2927.2013.00081.x
Citations Scopus - 8Web of Science - 9
Co-authors Brett Nixon, Shaun Roman
2012 Merriman-Jones JA, Jennings PC, McLaughlin EA, Jones KT, 'Effect of aging on superovulation efficiency, aneuploidy rates, and sister chromatid cohesion in mice aged up to 15 months', Biology of Reproduction, 86 1-6 (2012) [C1]
Citations Scopus - 24Web of Science - 23
Co-authors Keith Jones
2012 Sominsky Bar L, Meehan CL, Walker AK, Bobrovskaya L, McLaughlin EA, Hodgson DM, 'Neonatal immune challenge alters reproductive development in the female rat', Hormones and Behavior, 62 345-355 (2012) [C1]
Citations Scopus - 10Web of Science - 6
Co-authors Deborah Hodgson
2012 Sutherland JM, Keightley RA, Nixon B, Roman SD, Robker RL, Russell DL, McLaughlin EA, 'Suppressor of cytokine signaling 4 (SOCS4): Moderator of ovarian primordial follicle activation', Journal of Cellular Physiology, 227 1188-1198 (2012) [C1]
Citations Scopus - 9Web of Science - 7
Co-authors Shaun Roman, Brett Nixon
2012 Sobinoff AP, Pye VJ, Nixon B, Roman SD, McLaughlin EA, 'Jumping the gun: Smoking constituent BaP causes premature primordial follicle activation and impairs oocyte fusibility through oxidative stress', Toxicology and Applied Pharmacology, 260 70-80 (2012) [C1]
Citations Scopus - 22Web of Science - 19
Co-authors Shaun Roman, Brett Nixon
2012 Dun MD, Anderson AL, Bromfield EG, Asquith KL, Emmett BJ, McLaughlin EA, et al., 'Investigation of the expression and functional significance of the novel mouse sperm protein, a disintegrin and metalloprotease with thrombospondin type 1 motifs number 10 (ADAMTS10)', International Journal of Andrology, 35 572-589 (2012) [C1]
DOI 10.1111/j.1365-2605.2011.01235.x
Citations Scopus - 6Web of Science - 6
Co-authors John Aitken, Matt Dun, Brett Nixon
2012 Sobinoff AP, Nixon B, Roman SD, McLaughlin EA, 'Staying alive: PI3K pathway promotes primordial follicle activation and survival in response to 3MC-induced ovotoxicity', Toxicological Sciences, 128 258-271 (2012) [C1]
Citations Scopus - 15Web of Science - 14
Co-authors Brett Nixon, Shaun Roman
2012 McIver SC, Roman SD, Nixon B, McLaughlin EA, 'miRNA and mammalian male germ cells', Human Reproduction Update, 18 44-59 (2012) [C1]
Citations Scopus - 41Web of Science - 38
Co-authors Shaun Roman, Brett Nixon
2012 McIver SC, Stanger SJ, Santarelli DMF, Roman SD, Nixon B, McLaughlin EA, 'A unique combination of male germ cell mirnas coordinates gonocyte differentiation', PLoS One, 7 1-14 (2012) [C1]
Citations Scopus - 20Web of Science - 15
Co-authors Shaun Roman, Brett Nixon
2012 Siddall NA, Kalcina M, Johanson TM, Monk AC, Casagranda F, Been RP, et al., 'Drosophila Rbp6 Is an orthologue of vertebrate Msi-1 and Msi-2, but does not function redundantly with dMsi to regulate germline stem cell behaviour', PloS One, 7 e49810 (2012) [C1]
Citations Scopus - 2Web of Science - 3
2011 Gunter KM, McLaughlin EA, 'Translational control in germ cell development: A role for the RNA-binding proteins Musashi-1 and Musashi-2', IUBMB Life, 63 678-685 (2011) [C1]
Citations Scopus - 8Web of Science - 5
2011 Monk AC, Siddall NA, Fraser BA, McLaughlin EA, Hime GR, 'Differential roles of HOW in male and female Drosophila germline differentiation', PLoS ONE, 6 e28508 (2011) [C1]
Citations Scopus - 2Web of Science - 2
2011 Redgrove KA, Anderson AL, Dun MD, McLaughlin EA, O'Bryan MK, Aitken RJ, Nixon B, 'Involvement of multimeric protein complexes in mediating the capacitation-dependent binding of human spermatozoa to homologous zonae pellucidae', Developmental Biology, 356 460-474 (2011) [C1]
DOI 10.1016/j.ydbio.2011.05.674
Citations Scopus - 21Web of Science - 25
Co-authors John Aitken, Matt Dun, Brett Nixon
2011 Nixon B, Mitchell LA, Anderson AL, McLaughlin EA, O'Bryan MK, Aitken RJ, 'Proteomic and functional analysis of human sperm detergent resistant membranes', Journal of Cellular Physiology, 226 2651-2665 (2011) [C1]
DOI 10.1002/jcp.22615
Citations Scopus - 31Web of Science - 31
Co-authors John Aitken, Brett Nixon
2011 McLaughlin EA, Aitken RJ, 'Is there a role for immunocontraception?', Molecular and Cellular Endocrinology, 335 78-88 (2011) [C1]
DOI 10.1016/j.mce.2010.04.004
Citations Scopus - 15Web of Science - 13
Co-authors John Aitken
2011 Walker AK, Hiles SA, Sominsky Bar L, McLaughlin EA, Hodgson DM, 'Neonatal lipopolysaccharide exposure impairs sexual development and reproductive success in the Wistar rat', Brain, Behavior, and Immunity, 25 674-684 (2011) [C1]
Citations Scopus - 19Web of Science - 15
Co-authors Deborah Hodgson
2011 McLaughlin EA, Hime GR, 'Spermatids do it differently! Paip2a-the essential regulator of spermiogenesis?', Asian Journal of Andrology, 13 122-124 (2011) [C2]
DOI 10.1038/aja.2010.142
Citations Scopus - 3Web of Science - 2
2011 Sobinoff AP, Mahony M, Nixon B, Roman SD, McLaughlin EA, 'Understanding the villain: DMBA-induced preantral ovotoxicity involves selective follicular destruction and primordial follicle activation through PI3K/Akt and mTOR signaling', Toxicological Sciences, 123 563-575 (2011) [C1]
Citations Scopus - 21Web of Science - 20
Co-authors Brett Nixon, Shaun Roman
2010 Monk AC, Siddall NA, Volk T, Fraser BA, Quinn LM, McLaughlin EA, Hime GR, 'HOW is required for stem cell maintenance in the drosophila testis and for the onset of transit-amplifying divisions', Cell Stem Cell, 6 348-360 (2010) [C1]
DOI 10.1016/j.stem.2010.02.016
Citations Scopus - 16Web of Science - 16
2010 Sobinoff AP, Pye VJ, Nixon B, Roman SD, McLaughlin EA, 'Adding insult to injury: Effects of xenobiotic-induced preantral ovotoxicity on ovarian development and oocyte fusibility', Toxicological Sciences, 118 653-666 (2010) [C1]
DOI 10.1093/toxsci/kfq272
Citations Scopus - 17Web of Science - 17
Co-authors Shaun Roman, Brett Nixon
2009 McLaughlin EA, McIver SC, 'Awakening the oocyte: Controlling primordial follicle development', Reproduction, 137 1-11 (2009) [C1]
DOI 10.1530/rep-08-0118
Citations Scopus - 58Web of Science - 56
2009 Nixon B, Bielanowicz AJ, McLaughlin EA, Tanphaichitr N, Ensslin MA, Aitken RJ, 'Composition and significance of detergent resistant membranes in mouse spermatozoa', Journal of Cellular Physiology, 218 122-134 (2009) [C1]
DOI 10.1002/jcp.21575
Citations Scopus - 60Web of Science - 59
Co-authors Brett Nixon, John Aitken
2009 Yu DMT, Ajami K, Gall MG, Park J, Lee CS, Evans KA, et al., 'The in vivo expression of dipeptidyl peptidases 8 and 9', Journal of Histochemistry & Cytochemistry, 57 1025-1038 (2009) [C1]
DOI 10.1369/jhc.2009.953760
Citations Scopus - 39Web of Science - 38
2008 Koppers AJ, De Iuliis GN, Read JM, McLaughlin EA, Aitken RJ, 'Significance of mitochondrial reactive oxygen species in the generation of oxidative stress in spermatozoa', Journal of Clinical Endocrinology & Metabolism, 93 3199-3207 (2008) [C1]
DOI 10.1210/jc.2007-2616
Citations Scopus - 150Web of Science - 152
Co-authors John Aitken, Geoffry DeiuliIs
2007 Fitzsimmons C, McLaughlin EA, Mahony MJ, Clulow J, 'Optimisation of handling, activation and assessment procedures for Bufo marinus spermatozoa', Reproduction, Fertility and Development, 19 594-601 (2007) [C1]
DOI 10.1071/RD06124
Citations Scopus - 9Web of Science - 9
Co-authors John Clulow
2007 Aitken RJ, Wingate JK, De Iuliis GN, McLaughlin EA, 'Analysis of lipid peroxidation in human spermatozoa using BODIPY C11', Molecular Human Reproduction, 13 203-211 (2007) [C1]
DOI 10.1093/molehr/gal119
Citations Scopus - 60Web of Science - 63
Co-authors Geoffry DeiuliIs, John Aitken
2007 Nixon B, Aitken RJ, McLaughlin EA, 'New insights into the molecular mechanisms of sperm-egg interaction', Cellular and Molecular Life Sciences, 64 1805-1823 (2007) [C1]
DOI 10.1007/s00018-007-6552-x
Co-authors John Aitken, Brett Nixon
2007 Aitken RJ, McLaughlin EA, 'Molecular mechanisms of sperm capacitation: progesterone-induced secondary calcium oscillations reflect the attainment of a capacitated state', Society of Reproduction and Fertility Supplement, 63 273-293 (2007) [C1]
Citations Scopus - 26
Co-authors John Aitken
2006 De Iuliis GN, Wingate JK, Koppers AJ, McLaughlin EA, Aitken RJ, 'Definitive evidence for the nonmitochondrial production of superoxide anion by human spermatozoa', Journal of Clinical Endocrinology and Metabolism, 91 1968-1975 (2006) [C1]
DOI 10.1210/jc.2005-2711
Citations Scopus - 61Web of Science - 48
Co-authors John Aitken, Geoffry DeiuliIs
2006 Aitken RJ, Wingate JK, De Iuliis GN, Koppers AJ, McLaughlin EA, 'Cis-unsaturated Fatty acids stimulate reactive oxygen species generation and lipid peroxidation in human spermatozoa', Journal of Clinical Endocrinology and Metabolism, 91 4154-4163 (2006) [C1]
DOI 10.1210/jc.2006-1309
Citations Scopus - 76Web of Science - 73
Co-authors John Aitken, Geoffry DeiuliIs
2006 Holt JE, Roman SD, Aitken RJ, McLaughlin EA, 'Identification and characterization of a novel Mt-retrotransposon highly represented in the female mouse germline', Genomics, 87 490-499 (2006) [C1]
DOI 10.1016/j.ygeno.2005.08.015
Citations Scopus - 3Web of Science - 3
Co-authors Janet Holt, Shaun Roman, John Aitken
2006 Curry BJ, Holt JE, McLaughlin EA, Aitken RJ, 'Characterization of structure and expression of the Dzip1 gene in the rat and mouse', Genomics, 87 275-285 (2006) [C1]
DOI 10.1016/j.ygeno.2005.10.007
Citations Scopus - 2Web of Science - 2
Co-authors Janet Holt, John Aitken, Ben Curry
2006 Holt JE, Jackson A, Roman SD, Aitken RJ, Koopman PA, McLaughlin EA, 'CXCR4/SDF1 interaction inhibits the primordial to primary follicle transition in the neonatal mouse ovary', Developmental Biology, 293 449-460 (2006) [C1]
DOI 10.1016/j.ydbio.2006.02.012
Citations Scopus - 47Web of Science - 44
Co-authors Janet Holt, Shaun Roman, John Aitken
2006 Hutt KJ, McLaughlin EA, Holland MK, 'Primordial follicle activation and follicular development in the juvenile rabbit ovary', Cell and Tissue Research, 326 809-822 (2006) [C1]
DOI 10.1007/s00441-006-0223-3
Citations Scopus - 21Web of Science - 20
2006 Hutt KJ, McLaughlin EA, Holland MK, 'Kit ligand and c-Kit have diverse roles during mammalian oogenesis and folliculogenesis', Molecular Human Reproduction, 12 61-69 (2006) [C1]
DOI 10.1093/molehr/gal010
Citations Scopus - 80Web of Science - 76
2006 Prabhu SM, Meistrich ML, McLaughlin EA, Roman SD, Warne S, Mendis S, et al., 'Expression of c-Kit receptor mRNA and protein in the developing, adult and irradiated rodent testis', Reproduction, 131 489-499 (2006) [C1]
DOI 10.1530/rep.1.00968
Citations Scopus - 34Web of Science - 37
Co-authors Shaun Roman
2006 Mackenzie SM, McLaughlin EA, Perkins HD, French N, Sutherland T, Jackson RJ, et al., 'Immunocontraceptive effects on female rabbits infected with recombinant myxoma virus expressing rabbit ZP2 or ZP3', Biology of Reproduction, 74 511-521 (2006) [C1]
DOI 10.1095/biolreprod.105.046268
Citations Scopus - 22Web of Science - 19
2006 Hutt KJ, McLaughlin EA, Holland MK, 'KIT/KIT ligand in mammalian oogenesis and folliculogenesis: Roles in rabbit and murine ovarian follicle activation and oocyte growth', Biology of Reproduction, 75 421-433 (2006) [C1]
DOI 10.1095/biolreprod.106.051516
Citations Scopus - 52Web of Science - 47
2005 Telfer EE, Gosden RG, Byskov AG, Spears N, Albertini D, Andersen CY, et al., 'On regenerating the ovary and generating controversy', Cell, 122 821-822 (2005) [C1]
DOI 10.1016/j.cell.2005.09.004
Citations Scopus - 101Web of Science - 97
2004 Blackmore DG, Baillie LR, Holt JE, Dierkx LM, Aitken RJ, McLaughlin EA, 'Biosynthesis of the Canine Zona Pellucida Requires the Integrated Participation of Both Oocytes and Granulosa Cells', Biology of Reproduction, 71 661-668 (2004) [C1]
DOI 10.1095/biolreprod.104.028779
Citations Scopus - 26Web of Science - 25
Co-authors Janet Holt, John Aitken
2004 Baker MA, Krutskikh A, Curry BJ, McLaughlin EA, Aitken RJ, 'Identification of Cytochrome P450-Reductase as the Enzyme Responsible for NADPH-Dependent Lucigenin and Tetrazolium Salt Reduction in Rat Epididymal Sperm Preparations', Biology of Reproduction, 71 307-318 (2004) [C1]
DOI 10.1095/biolreprod.104.027748
Citations Scopus - 35Web of Science - 34
Co-authors John Aitken, Mark Baker, Ben Curry
2004 Asquith KL, Baleato R, McLaughlin EA, Nixon B, Aitken RJ, 'Tyrosine phosphorylation activates surface chaperones facilitating sperm-zona recognition', Journal of Cell Science, 117 3645-3657 (2004) [C1]
DOI 10.1242/jcs.01214
Citations Scopus - 105Web of Science - 97
Co-authors Brett Nixon, John Aitken
2004 Kerr PJ, Perkins HD, Inglis B, Stagg R, McLaughlin EA, Collins SV, Van Leeuwen BH, 'Expression of rabbit IL-4 by recombinant myxoma viruses enhances virulence and overcomes genetic resistance to myxomatosis', Virology, 324 117-128 (2004) [C1]
DOI 10.1016/j.virol.2004.02.031
Citations Scopus - 22Web of Science - 21
2004 Curry BJ, Su H, Law EG, McLaughlin EA, Nixon B, Aitken RJ, 'Identification of RARhoGAP, a novel putative RhoGAP gene expressed in male germ cells', Genomics, 84 406-418 (2004) [C1]
DOI 10.1016/j.ygeno.2004.03.004
Citations Scopus - 9Web of Science - 10
Co-authors Ben Curry, John Aitken, Brett Nixon
2004 Aitken RJ, Ryan AL, Baker MA, McLaughlin EA, 'Redox activity associated with the maturation and capacitation of mammalian spermatozoa', Free Radical Biology and Medicine, 36 994-1010 (2004) [C1]
DOI 10.1016/j.freeradbiomed.2004.01.017
Citations Scopus - 75Web of Science - 66
Co-authors John Aitken, Mark Baker
2003 McLaughlin EA, Holland MK, Aitken RJ, 'Contraceptive vaccines', Expert Opinion on Biological Therapy, 3 829-841 (2003) [C1]
DOI 10.1517/14712598.3.5.829
Citations Scopus - 11Web of Science - 8
Co-authors John Aitken
2002 Hancock P, McLaughlin EA, 'British Andrology Society guidelines for the assessment of post vasectomy semen samples', Journal of Clinical Pathology, 55 812-816 (2002) [C1]
Citations Scopus - 49Web of Science - 34
2002 McLaughlin EA, 'Cryopreservation, screening and storage of sperm - The challenges for the twenty-first century', Human Fertility, 5 (2002) [C1]

The advent of HIV and the serious nature of the sequelae resulted in a major reassessment of artificial insemination practices in the UK. The development of human semen cryopreser... [more]

The advent of HIV and the serious nature of the sequelae resulted in a major reassessment of artificial insemination practices in the UK. The development of human semen cryopreservation had enormous impact on reproductive medicine and the availability of cryopreserved quarantined donor semen became a mainstay for the treatment of male infertility in the UK. The regulation and accreditation of assisted reproductive technologies and the introduction of peer-reviewed guidelines have largely standardized clinical and laboratory practice. The introduction of assisted fertilization techniques such as intracytoplasmic sperm injection, testicular sperm retrieval and improved oncology treatments have placed pressure on reproductive biologists and cryobiologists to design and use cryopreservation protocols for the optimum survival of sperm.

Citations Scopus - 5
2001 Ford WCL, Williams KM, Harrison S, Rees JM, Ray BD, McLaughlin EA, Hull MGR, 'Value of the hamster oocyte test and computerised measurements of sperm motility in predicting if four or more viable embryos will be obtained in an IVF cycle', INTERNATIONAL JOURNAL OF ANDROLOGY, 24 109-119 (2001) [C1]
DOI 10.1046/j.1365-2605.2001.00284.x
Citations Scopus - 7Web of Science - 5
2001 McLaughlin EA, Frayne J, Bloomberg G, Hall L, 'Do fertilin beta and cyritestin play a major role in mammalian sperm-oolemma interactions? A critical re-evaluation of the use of peptide mimics in identifying specific oocyte recognition proteins', MOLECULAR HUMAN REPRODUCTION, 7 313-317 (2001)
DOI 10.1093/molehr/7.4.313
Citations Scopus - 22Web of Science - 18
2001 McLaughlin E, 'The screeing of sperm donors - in search of the perfect male', ART & Science, (2001) [C3]
2000 McLaughlin EA, 'Recruitment of only cytomegalovirus (CMV) negative semen donors', HUMAN REPRODUCTION, 15 2248-2249 (2000)
2000 McLaughlin EA, 'Recruitment of only cytomegalovirus (CMV) negative semen donors', HUMAN REPRODUCTION, 15 2247-2247 (2000)
Citations Web of Science - 2
2000 Curson R, Karakosta C, McLaughlin EA, 'Recruitment of only cytomegalovirus (CMV) negative semen donors (multiple letters)', Human Reproduction, 15 2247-2249 (2000)
Citations Scopus - 5
1999 Whittington K, Harrison SC, Williams KM, Day JL, Mclaughlin EA, Hull MGR, Ford WCL, 'Reactive oxygen species (ROS) production and the outcome of diagnostic tests of sperm function', INTERNATIONAL JOURNAL OF ANDROLOGY, 22 236-242 (1999)
DOI 10.1046/j.1365-2605.1999.00174.x
Citations Scopus - 39Web of Science - 32
1999 McLaughlin EA, 'Ensuring the safe cryopreservation of tissues & cells', CRYO-LETTERS, 20 133-136 (1999)
Citations Scopus - 2
1998 McLaughlin EA, Day J, Harrison S, Mitchell J, Prosser C, Hull M, 'Recruitment of gamete donors and payment of expenses', HUMAN REPRODUCTION, 13 1130-1132 (1998)
Citations Scopus - 9Web of Science - 7
1998 Hull MGR, Williams JAC, Ray B, McLaughlin EA, Akande VA, Ford WCL, 'The contribution of subtle oocyte or sperm dysfunction affecting fertilization in endometriosis-associated or unexplained infertility: A controlled comparison with tubal infertility and use of donor spermatozoa', HUMAN REPRODUCTION, 13 1825-1830 (1998)
DOI 10.1093/humrep/13.7.1825
Citations Scopus - 72Web of Science - 61
1998 Williams K, Frayne J, McLaughlin EA, Hall L, 'Expression of extracellular superoxide dismutase in the human male reproductive tract, detected using antisera raised against a recombinant protein', MOLECULAR HUMAN REPRODUCTION, 4 235-242 (1998)
DOI 10.1093/molehr/4.3.235
Citations Scopus - 21Web of Science - 21
1997 Williams JAC, Ray B, McLaughlin EA, Hull MGR, 'The contribution of subtle oocyte or sperm dysfunction to endometriosis-associated and unexplained infertility', HUMAN REPRODUCTION, 12 P157-P157 (1997)
1996 Coulson C, McLaughlin EA, Harris S, Ford WCL, Hull MGR, 'Randomized controlled trial of cervical cap with intracervical reservoir versus standard intracervical injection to inseminate cryopreserved donor semen', HUMAN REPRODUCTION, 11 84-87 (1996)
Citations Scopus - 4Web of Science - 5
1996 Liversedge NH, Jenkins JM, Keay SD, McLaughlin EA, AlSufyan H, Maile LA, et al., 'Antibiotic treatment based on seminal cultures from asymptomatic male partners in in-vitro fertilization is unnecessary and may be detrimental', HUMAN REPRODUCTION, 11 1227-1231 (1996)
Citations Scopus - 35Web of Science - 20
1996 Ford WCL, Williams KM, McLaughlin EA, Harrison S, Ray B, Hull MGR, 'The indirect immunobead test for seminal antisperm antibodies and fertilization rates at in-vitro fertilization', HUMAN REPRODUCTION, 11 1418-1422 (1996)
Citations Web of Science - 29
1995 PLANT A, MCLAUGHLIN EA, FORD WCL, 'INTRACELLULAR CALCIUM MEASUREMENTS IN INDIVIDUAL HUMAN SPERM DEMONSTRATE THAT THE MAJORITY CAN RESPOND TO PROGESTERONE', FERTILITY AND STERILITY, 64 1213-1215 (1995)
Citations Web of Science - 32
1995 FOWLER PA, FAHY U, CULLER MD, KNIGHT PG, WARDLE PG, MCLAUGHLIN EA, et al., 'GONADOTROPIN SURGE-ATTENUATING FACTOR BIOACTIVITY IS PRESENT IN FOLLICULAR-FLUID FROM NATURALLY CYCLING WOMEN', HUMAN REPRODUCTION, 10 68-74 (1995)
Citations Scopus - 18Web of Science - 20
1994 FOWLER PA, FRASER M, CUNNINGHAM P, KNIGHT PG, BYRNE B, MCLAUGHLIN EA, et al., 'HIGHER GONADOTROPIN SURGE-ATTENUATING FACTOR BIOACTIVITY IS FOUND IN SMALL FOLLICLES FROM SUPEROVULATED WOMEN', JOURNAL OF ENDOCRINOLOGY, 143 33-44 (1994)
DOI 10.1677/joe.0.1430033
Citations Scopus - 19Web of Science - 27
1994 MCLAUGHLIN EA, FORD WCL, HULL MGR, 'ADENOSINE-TRIPHOSPHATE AND MOTILITY CHARACTERISTICS AF FRESH AND CRYOPRESERVED HUMAN SPERMATOZOA', INTERNATIONAL JOURNAL OF ANDROLOGY, 17 19-23 (1994)
DOI 10.1111/j.1365-2605.1994.tb01203.x
Citations Web of Science - 4
1994 FORD WCL, REES JM, McLAUGHLIN EA, LING L, HULL MGR, 'Pentoxifylline acts synergistically with A23187 to increase the penetration of zona-free hamster oocytes by cryopreserved human spermatozoa', International Journal of Andrology, 17 199-204 (1994)
DOI 10.1111/j.1365-2605.1994.tb01243.x
Citations Web of Science - 6
1994 CORRIGAN E, MCLAUGHLIN EA, COULSON N, FORD WCL, HULL MGR, 'THE EFFECT OF HALVING THE STANDARD-DOSE OF CRYOPRESERVED SEMEN FOR DONOR INSEMINATION - A CONTROLLED-STUDY OF CONCEPTION RATES', HUMAN REPRODUCTION, 9 330-333 (1994)
Citations Scopus - 7Web of Science - 7
1994 MCLAUGHLIN EA, FORD WCL, 'EFFECTS OF CRYOPRESERVATION ON THE INTRACELLULAR CALCIUM-CONCENTRATION OF HUMAN SPERMATOZOA AND ITS RESPONSE TO PROGESTERONE', MOLECULAR REPRODUCTION AND DEVELOPMENT, 37 241-246 (1994)
DOI 10.1002/mrd.1080370216
Citations Scopus - 39Web of Science - 40
1993 MCLAUGHLIN EA, FORD WCL, HULL MGR, 'EFFECTS OF CRYOPRESERVATION ON THE HUMAN SPERM ACROSOME AND ITS RESPONSE TO A23187', JOURNAL OF REPRODUCTION AND FERTILITY, 99 71-76 (1993)
Citations Scopus - 18Web of Science - 21
1992 MCLAUGHLIN EA, FORD WCL, HULL MGR, 'MOTILITY CHARACTERISTICS AND MEMBRANE INTEGRITY OF CRYOPRESERVED HUMAN SPERMATOZOA', JOURNAL OF REPRODUCTION AND FERTILITY, 95 527-534 (1992)
Citations Web of Science - 61
1992 MCLAUGHLIN EA, FORD WCL, HULL MGR, 'THE CONTRIBUTION OF THE TOXICITY OF A GLYCEROL EGG-YOLK CITRATE CRYOPRESERVATIVE TO THE DECLINE IN HUMAN SPERM MOTILITY DURING CRYOPRESERVATION', JOURNAL OF REPRODUCTION AND FERTILITY, 95 749-754 (1992)
Citations Web of Science - 32
1992 FORD WCL, PONTING FA, MCLAUGHLIN EA, REES JM, HULL MGR, 'CONTROLLING THE SWIMMING SPEED OF HUMAN SPERM BY VARYING THE INCUBATION-TEMPERATURE AND ITS EFFECT ON CERVICAL-MUCUS PENETRATION', INTERNATIONAL JOURNAL OF ANDROLOGY, 15 127-134 (1992)
DOI 10.1111/j.1365-2605.1992.tb01121.x
Citations Web of Science - 10
1992 FORD WCL, MCLAUGHLIN EA, PRIOR SM, REES JM, WARDLE PG, HULL MGR, 'THE YIELD, MOTILITY AND PERFORMANCE IN THE HAMSTER EGG TEST OF HUMAN SPERMATOZOA PREPARED FROM CRYOPRESERVED SEMEN BY 4 DIFFERENT METHODS', HUMAN REPRODUCTION, 7 654-659 (1992)
Citations Web of Science - 24
1991 FORD WCL, REES JM, MCLAUGHLIN EA, GODDARD RJ, HULL MGR, 'THE EFFECT OF A23187 CONCENTRATION AND EXPOSURE TIME ON THE OUTCOME OF THE HAMSTER EGG PENETRATION TEST', INTERNATIONAL JOURNAL OF ANDROLOGY, 14 127-139 (1991)
DOI 10.1111/j.1365-2605.1991.tb01074.x
Citations Scopus - 2Web of Science - 9
1990 McLaughlin EA, Ford WC, 'A comparison of the freezing of human semen in the uncirculated vapour above liquid nitrogen and in a commercial semi-programmable freezer.', Human Reproduction, 5 724-728 (1990)
Citations Scopus - 28Web of Science - 25
1988 HARRIS MA, REES JM, MCLAUGHLIN EA, FORD WCL, WARDLE PG, HULL MGR, WATHES DC, 'AN EVALUATION OF THE ROLE OF RELAXIN IN THE PENETRATION OF CERVICAL-MUCUS BY SPERMATOZOA', HUMAN REPRODUCTION, 3 856-860 (1988)
Citations Scopus - 6Web of Science - 10
1987 WARDLE PG, MCLAUGHLIN E, SYKES JA, HULL MGR, 'INTRAUTERINE INSEMINATION', LANCET, 1 270-270 (1987)
Citations Scopus - 2Web of Science - 1
1987 WALKER A, GREGSON S, MCLAUGHLIN E, 'ATTITUDES TOWARDS DONOR INSEMINATION - A POST-WARNOCK SURVEY', HUMAN REPRODUCTION, 2 745-750 (1987)
Citations Web of Science - 17
1987 RAY BD, MCDERMOTT A, WARDLE PG, CORRIGAN E, MITCHELL JD, MCLAUGHLIN EA, et al., 'INVITRO FERTILIZATION - FERTILIZATION FAILURE DUE TO TOXIC CATHETERS', JOURNAL OF IN VITRO FERTILIZATION AND EMBRYO TRANSFER, 4 58-61 (1987)
DOI 10.1007/BF01555438
Citations Scopus - 7Web of Science - 8
1986 WARDLE PG, FOSTER PA, MITCHELL JD, MCLAUGHLIN EA, SYKES JAC, CORRIGAN E, et al., 'ENDOMETRIOSIS AND IVF - EFFECT OF PRIOR THERAPY', LANCET, 1 276-277 (1986)
Citations Scopus - 34Web of Science - 33
1986 WARDLE PG, FOSTER PA, MITCHELL JD, MCLAUGHLIN EA, WILLIAMS JAC, CORRIGAN E, et al., 'NORETHISTERONE TREATMENT TO CONTROL TIMING OF THE IVF CYCLE', HUMAN REPRODUCTION, 1 455-457 (1986)
Citations Scopus - 11Web of Science - 20
1986 WATHES DC, WARDLE PG, REES JM, MITCHELL JD, MCLAUGHLIN EA, HULL MGR, PORTER DG, 'IDENTIFICATION OF RELAXIN IMMUNOREACTIVITY IN HUMAN FOLLICULAR-FLUID', HUMAN REPRODUCTION, 1 515-517 (1986)
Citations Scopus - 8Web of Science - 9
1986 WARDLE PG, MCLAUGHLIN EA, WILLIAMS JAC, MITCHELL JD, FOSTER PA, CORRIGAN E, et al., 'SEMINAL ANALYSIS AND CLINICAL SPERM FUNCTION-TESTS - DEFINITION OF NORMAL VALUES USING INVITRO FERTILIZATION (IVF)', BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 93 1195-1195 (1986)
1985 WARDLE PG, MITCHELL JD, MCLAUGHLIN EA, RAY BD, MCDERMOTT A, HULL MGR, 'ENDOMETRIOSIS AND OVULATORY DISORDER - REDUCED FERTILIZATION INVITRO COMPARED WITH TUBAL AND UNEXPLAINED INFERTILITY', LANCET, 2 236-239 (1985)
Citations Scopus - 117Web of Science - 146
1983 MCLAUGHLIN EA, BROMWICH PD, MACKEN AM, WALKER AP, NEWTON J, 'USE OF HOME INSEMINATION IN PROGRAMS OF ARTIFICIAL-INSEMINATION WITH DONOR SEMEN', BRITISH MEDICAL JOURNAL, 287 1110-1110 (1983)
Citations Web of Science - 1
Show 112 more journal articles

Review (2 outputs)

Year Citation Altmetrics Link
2007 Nixon B, Aitken RJ, McLaughlin EA, 'New insights into the molecular mechanisms of sperm-egg interaction', CELLULAR AND MOLECULAR LIFE SCIENCES (2007) [D1]
DOI 10.1007/s00018-007-6552-x
Citations Scopus - 61Web of Science - 59
Co-authors Brett Nixon, John Aitken
1998 Avery SM, McLaughlin EA, Dawson KJ, 'Safe cryopreservation of sperm and embryos.', Human Fertility (1998)

Conference (61 outputs)

Year Citation Altmetrics Link
2012 Sobinoff AP, Beckett EL, Nixon B, Roman SD, Hansbro PM, McLaughlin EA, 'The impact of maternal cigarette smoke exposure on the male germline', Abstracts. The Annual Scientific Meeting of the Endocrine Society of Australia and the Society for Reproductive Biology 2012, Gold Coast, QLD (2012) [E3]
Co-authors Philip Hansbro, Shaun Roman, Brett Nixon
2012 Sutherland JM, Fraser BA, Siddall NA, Hime GR, Davidson T-L, Koopman P, McLaughlin EA, 'Musashi-2: an essential regulator of DNA recombination and repair', Abstracts. The Annual Scientific Meeting of the Endocrine Society of Australia and the Society for Reproductive Biology 2012, Gold Coast, QLD (2012) [E3]
2012 Sominsky Bar L, Moussavi M, Sobinoff AP, McLaughlin EA, Hodgson DM, 'Postnatal peripheral inflammatory challenge alters expression of ovarian signalling pathway - Implications for impaired reproductive development', Abstracts. The Annual Scientific Meeting of the Endocrine Society of Australia and the Society for Reproductive Biology 2012, Gold Coast, QLD (2012) [E3]
Co-authors Deborah Hodgson
2012 Loveland K, McLaughlin EA, Szczepny A, Jans D, 'Expression of hedgehog pathway regulators in the adult testis reveals dynamic control of signalling activity', Journal of Andrology, Tucson, AZ (2012) [E3]
2012 Sominsky Bar L, Meehan CL, Walker AK, Bobrovskaya L, McLaughlin EA, Hodgson DM, 'Programming of reproductive development by neonatal immunological challenge: Evidence for transgenerational inheritance', Brain, Behavior, and Immunity, San Diego, CA (2012) [E3]
Co-authors Deborah Hodgson
2010 Siddall NA, Monk AC, Horvay K, Kalcina M, Johanson TM, Casagranda F, et al., 'Genetic regulation of stem cell differentiation by transcriptional and translational repressors', OzBio 2010: The Molecules of Life - from Discovery to Biotechnology. Abstracts, Melbourne, Vic (2010) [E3]
2010 McLaughlin EA, Fraser BA, Pye VJ, Bigland MJ, Siddall NA, Hime GR, 'RNA binding protein Msi2: Cell cycle regulator in spermatogenesis', OzBio 2010: The Molecules of Life - from Discovery to Biotechnology. Abstracts, Melbourne, Vic (2010) [E3]
2010 Fraser BA, Sobinoff AP, Pye VJ, Roman SD, Hime GR, Siddall NA, et al., 'Targets of RNA-binding protein Musashi-1 in mouse germ cell development', OzBio 2010: The Molecules of Life - from Discovery to Biotechnology. Poster Abstracts, Melbourne, Australia (2010) [E3]
Co-authors Shaun Roman
2010 McIver SC, Roman SD, Nixon B, McLaughlin EA, 'MicroRNA signalling in early male germ cells', OzBio 2010: The Molecules of Life - from Discovery to Biotechnology. Poster Abstracts, Melbourne, Vic (2010) [E3]
Co-authors Shaun Roman, Brett Nixon
2010 Pye VJ, Sobinoff AP, Nixon B, Roman SD, McLaughlin EA, 'Xenobiotics; influence on long term oocyte viability', OzBio 2010: The Molecules of Life - from Discovery to Biotechnology. Poster Abstracts, Melbourne, Vic (2010) [E3]
Co-authors Brett Nixon, Shaun Roman
2010 Redgrove KA, McLaughlin EA, O'Bryan MK, Aitken RJ, Nixon B, 'Identification and characterisation of surface protein complexes in human spermatozoa', OzBio 2010: The Molecules of Life - from Discovery to Biotechnology. Poster Abstracts, Melbourne, Vic (2010) [E3]
Co-authors Brett Nixon, John Aitken
2010 Sobinoff AP, Pye VJ, Nixon B, Roman SD, McLaughlin EA, 'Consistent mechanism of primordial follicle activation in neonatal mouse ovotoxicity', OzBio 2010: The Molecules of Life - from Discovery to Biotechnology. Poster Abstracts, Melbourne, Vic (2010) [E3]
Co-authors Brett Nixon, Shaun Roman
2010 Redgrove KA, Nixon B, McLaughlin EA, O'Bryan MK, Aitken RJ, 'Identification and Characterisation of Surface Protein Complexes in Human Spermatozoa', Reproduction, Fertility and Development, Sydney (2010) [E3]
Co-authors John Aitken, Brett Nixon
2010 Sobinoff AP, Pye VJ, Nixon B, Roman SD, McLaughlin EA, 'Short Term Xenobiotic Exposure Compromises Long Term Oocyte Viability', Reproduction, Fertility and Development, Sydney (2010) [E3]
Co-authors Shaun Roman, Brett Nixon
2010 Sutherland JM, Keightley RA, Robker RL, Russell DL, McLaughlin EA, 'JAK/STAT Signalling in Folliculogenesis', Reproduction, Fertility and Development, Sydney (2010) [E3]
2010 Watson LN, Robker RL, Dunning KR, McLaughlin EA, Russell DL, 'Conditional Targeted Deletions of STAT3 to Identify its Role in Oocytes and Granulosa Cells', Reproduction, Fertility and Development, Sydney (2010) [E3]
2010 McIver SC, Roman SD, Nixon B, McLaughlin EA, 'Microrna and Early Male Germ Cells', Reproduction, Fertility and Development, Sydney (2010) [E3]
Co-authors Shaun Roman, Brett Nixon
2010 Gunter KM, Fraser BA, Sobinoff AP, Pye VJ, Siddall NA, Hime GR, McLaughlin EA, 'Translational Control in Folliculogenesis and Oocyte Development: A Role for RNA-Binding Protein Musashi-1', Reproduction, Fertility and Development, Sydney (2010) [E3]
2010 McLaughlin EA, Fraser BA, Pye VJ, Bigland MJ, Siddall NA, Hime GR, 'Musashi Family of RNA Binding Proteins: Cell Cycle Regulators in Spermatogenesis', Reproduction, Fertility and Development, Sydney (2010) [E3]
2010 Hopkins LA, Pye VJ, Fraser BA, Holt JE, Jones KT, McLaughlin EA, 'The Role of Fizzy Related 1 in Male Meiosis', Reproduction, Fertility and Development, Sydney (2010) [E3]
Co-authors Keith Jones, Janet Holt
2010 Anderson AL, Mitchell LA, McLaughlin EA, O'Bryan MK, Aitken RJ, Nixon B, 'Proteomic and Functional Analysis of Human Sperm Detergent Resistant Membranes', Reproduction, Fertility and Development, Sydney (2010) [E3]
DOI 10.1002/jcp.22615
Co-authors John Aitken, Brett Nixon
2010 Bernstein IR, McLaughlin EA, O'Bryan MK, 'SLX4, A Key Regulator of Meisosis and DNA Repair in the Male Germline', Reproduction, Fertility and Development, CSIRO Publishing (2010) [E3]
2010 Tannock SJ, McLaughlin EA, Aitken RJ, Roman SD, 'SPIF - A Novel Testis-Specific Gene and its Interaction with PKA', Reproduction, Fertility and Development, Sydney (2010) [E3]
Co-authors John Aitken, Shaun Roman
2009 Roman SD, Stanger SJ, Borg Z, Low JL, McClymont SL, McLaughlin EA, 'Characterisation of spermatogonial stem cells', Regulatory Networks in Stem Cells: Program & Abstract Book, Singapore (2009) [E3]
Co-authors Shaun Roman
2008 Fraser BA, Sobinoff A, Hime G, Siddall N, Roman SD, McLaughlin EA, 'The role of the RNA-binding protein, Musashi-1 in murine spermatogonial stem cell maintenance', Proceedings of 41st Annual Meeting of the Society for the Study of Reproduction., Kailua-Kona, Hawaii (2008) [E3]
Co-authors Shaun Roman
2008 Nixon B, Bielanowicz AJ, McLaughlin EA, Tanphaichitr N, Ensslin M, Aitken RJ, 'The composition and significance of lipid rafts in mouse spermatozoa', Proceedings of 41st Annual Meeting of the Society for the Study of Reproduction., Kailua-Kona, Hawaii (2008) [E3]
Co-authors John Aitken, Brett Nixon
2008 McLaughlin EA, Gunter KM, Woollett K, Roman SD, 'Chemokines: Role in germ cell migration and survival', Proceedings of 41st Annual Meeting of the Society for the Study of Reproduction. "Reproductive Biology: Basic Discoveries that Affect Our Lives", Kailua-Kona, Hawaii (2008) [E3]
Co-authors Shaun Roman
2008 Nixon B, Bielanowicz A, McLaughlin E, Tanphaichitr N, Ensslin M, Aitken R, 'The composition and significance of lipid rafts in mouse spermatozoa', BIOLOGY OF REPRODUCTION, Kona, HI (2008) [E3]
Co-authors Brett Nixon
2007 Gunter KM, Fraser BA, Holt JE, Stanger SJ, Aitken RJ, Roman SD, McLaughlin EA, 'CXCR4/SDF1 interaction in the neonatal mouse testes', 7th Hunter Cellular Biology Meeting. Program, Hunter Valley, NSW (2007) [E3]
Co-authors John Aitken, Janet Holt, Shaun Roman
2007 Koppers AJ, McLaughlin EA, Aitken RJ, 'Mitochondria are a significant source of reactive oxygen species in human spermatozoa', Combined Conference Abstracts - ComBio 2007 Conference, Sydney (2007) [E3]
Co-authors John Aitken
2007 Hime GR, Siddall NA, Monk AC, Marriner NL, McLaughlin EA, 'Genetics of stem cells - How fruitflies can assist reproductive technology', Proceedings of the Thirty-Eighth Annual Conference Society for Reproductive Biology, Christchurch, New Zealand (2007) [E3]
2007 McLaughlin EA, 'Under attack: Germ cell defences against environmental toxins?', Proceedings of the Thirty-Eighth Annual Conference Society for Reproductive Biology, Christchurch, New Zealand (2007) [E3]
2007 Roman SD, Stanger SJ, Fraser BA, Borg Z, Low JL, McClymont SL, McLaughlin EA, 'Isolating and genotyping spermatogonial stem cells', Proceedings of the Thirty-Eighth Annual Conference Society for Reproductive Biology, Christchurch, New Zealand (2007) [E3]
Co-authors Shaun Roman
2006 Fraser BA, Holt JE, Andrew J, Roman SD, Stanger SJ, Aitken RJ, et al., 'CXCR4/SDF1 Interactionin the Embryonic and Neonatal Mpise Testes', Abstracts, Brisbane Convention Centre, QLD, Australia (2006) [E3]
Co-authors John Aitken, Janet Holt, Shaun Roman
2006 McLaughlin EA, Dorey RA, Roman SD, Aitken RJ, 'Xenobiotis and Fertility: Expression Profiling of Defence Mechanisms Present in Murine Ovary', Abstract Book, Lorne, VIC, Australia (2006) [E3]
Co-authors Shaun Roman, John Aitken
2006 Schjenken JE, Gilliam E, Borg Z, Aitken RJ, McLaughlin EA, Roman SD, 'Cytocrome P450 2E2 Mediates Acrylamide Damage to the Male Germ Line', Abstract Book, Lorne, VIC, Australia (2006) [E3]
Co-authors John Aitken, Shaun Roman
2006 Aitken RJ, 'Impact of unsaturated fatty acids on human sperm function', Abstracts, Qwest Center Omaha, Omaha, Nebraska (2006) [E3]
Co-authors John Aitken
2006 Aitken RJ, McLaughlin EA, 'Molecular mechanism in spem capacitation: progesterone induced secondary calcium oscillations reflect the attainment of a capacitated state', Book of Abstracts, New Delhi (2006) [E3]
Co-authors John Aitken
2006 Paul JW, Aitken RJ, McLaughlin EA, 'Oolemmal Proteomics: Characterisation of Glycophosphatidylinositol Anchored Proteins Involved in Murine Fertilisation', Book of Abstracts, Lorne, Victoria, Australia (2006) [E3]
Co-authors John Aitken, Jonathan Paul
2006 Holt JE, Andrew J, Roman SD, Stanger SJ, Aitken RJ, Peter K, McLaughlin EA, 'CXCR4/SDF-1 interaction in the embryonic and neonatal mouse tests', Book of Abstracts, Chicago, Illinois (2006) [E3]
Co-authors Janet Holt, Shaun Roman, John Aitken
2005 Ellem GK, McLaughlin EA, 'Tales from the coalface: From tragedy to triumph in a blended learning approach to the teaching of 1st year biology', Proceedings of the Blended Learning in Science Teaching and Learning Symposium, Sydney, NSW (2005) [E1]
2005 Holt JE, Aitken RJ, Roman SD, McLaughlin E, 'Use of RNA interference for the functional analysis of genes involved in ovarian development', MECHANISMS OF DEVELOPMENT (2005) [E3]
Co-authors John Aitken, Janet Holt, Shaun Roman
2005 Hime G, Marriner N, McLaughlin E, Roman S, Loveland K, Siddall N, 'The RNA-binding protein musashi is required for stem cell maintenance in the Drosophila testis', MECHANISMS OF DEVELOPMENT (2005) [E3]
Co-authors Shaun Roman
2005 Siddall NA, Marriner NL, McLaughlin EA, Roman SD, Loveland KL, Hime GR, 'The RNA-binding protein Musashi is required for stem cell maintenance in the Drosophila testis', 2nd Great Barrier Reef Drosophila Conference, Cairns, Australia (2005) [E3]
2005 McLaughlin EA, Borg Z, Roman SD, Ball P, Loveland KL, Siddall NA, Hime GR, 'Musashi 1 & 2: role in murine spermatogonial stem cell maintenance and spermatogenesis', ASMR Hormones Fertility & Cancer, Couran Cove, Queensland (2005) [E1]
2005 Williams JE, Aitken RJ, McLaughlin EA, 'Maintenance of feline primordial follicles by in vitro culture', ComBio 2005 (ABSBMB, ASPP, ANZCDB), Adelaide, Australia (2005) [E3]
2005 Holt JE, Aitken RJ, Roman SD, McLaughlin EA, 'Use of RNAi for the functional analysis of genes involved in ovarian development', European Society For Human Reproduction And Embryology, Paris, France. (2005) [E3]
2005 Holt JE, Aitken RJ, Roman S, McLaughlin EA, 'Expression of the chemokine CXCl12 and its receptor CXCR4 in the activating mammalian ovarian follicle.', Fertility 2005 Conference, Conventry, UK (2005) [E3]
2004 Holt JE, Aitken RJ, Roman SD, McLaughlin EA, 'Expression of the Chemokine CXCL12 and its receptor CXCR4 in the activating Mammalian Ovarian follicle', Reproduction, Fertility and Development, Sydney (2004) [E3]
Co-authors John Aitken, Janet Holt, Shaun Roman
2004 Paul JW, McLaughlin EA, Aitken RJ, 'Oolemmal Proteomics: Identification of the Oocyte Cell Surface Protein Complexes Involved in Sperm-egg Interaction', Reproduction, Fertility and Development, Sydney (2004) [E3]
Co-authors Jonathan Paul, John Aitken
2004 Hutt KJ, McLaughlin EA, Holland MK, 'Kit Ligand promotes follicle activation in cultured neonatal mouse ovaries but not in cultured rabbit ovarian cortical explants', Biology of Reproduction 2004 Special Issue, Vancouver, Canada (2004) [E3]
2004 Asquith KL, Nixon B, McLaughlin EA, Aitken RJ, 'Tyrosine phosphorylation of mouse sperm proteins in a prerequisite for Zona Pellucida binding: potential involvement of molecular chaperones', Biology of Reproduction 2004 Special Issue, Vancouver, Canada (2004) [E3]
Co-authors John Aitken, Brett Nixon
2004 Roman SD, McLaughlin EA, 'Peer pressure and performance: meaningful team work', Proceedings of Scholarly Inquiry into Science Teaching and Leaning, University of Sydney (2004) [E3]
Co-authors Shaun Roman
2003 Holt JE, Aitken RJ, Roman SD, McLaughlin EA, 'Gene expression in the activating mammalian ovarian follicle', ComBio Combined Conference Abstracts, Melbourne (2003) [E3]
Co-authors John Aitken, Shaun Roman, Janet Holt
2003 Blackmore DG, McLaughlin EA, Aitken RJ, 'Lectin expression patterns of feline and canine oogenesis', ComBio Combined Conference Abstracts, Melbourne (2003) [E3]
Co-authors John Aitken
2003 Asquith KL, McLaughlin EA, Nixon B, Aitken RJ, 'Localisation of Tyrosine Phosphorylated Proteins on Mouse Spermatozoa during Zona Pellucida Interaction and Characterisation of Sperm Surface Phosphoproteins', Society for Reproductive Biology Proceedings of the Thirty-fourth Annual Conference, Melbourne (2003) [E3]
Co-authors Brett Nixon, John Aitken
2003 Hutt KJ, McLaughlin EA, Holland MK, 'The effect of kit ligand on follicle growth initiation in cultured rabbit and mouse ovaries', Society for Reproductive Biology Proceedings of the Thirty-fourth Annual Conference, Melbourne (2003) [E3]
2002 McLaughlin EA, Robinson A, Inglis B, Swan J, Holland M, Kerr P, 'Immunocontraceptive effect of recombinant porcine Zona Pellucida C protein in rabbits', Proceedings of the Thirty-third Annual Conference of the Society for Reproductive Biology, Adelaide, SA (2002) [E3]
1997 McLaughlin EA, Frayne J, Barker HL, Jury JA, Jones R, Ford WCL, Hall L, 'Cloning and sequence analysis of rat fertilin alpha and beta - Developmental expression, processing and immunolocalization', MOLECULAR HUMAN REPRODUCTION, YORK, ENGLAND (1997)
DOI 10.1093/molehr/3.9.801
Citations Scopus - 36Web of Science - 30
1997 Hull MGR, Cahill DJ, Harlow CR, McLaughlin EA, Maile LA, Mears J, et al., 'Oocyte quality in endometriosis', HUMAN OOCYTES: FROM PHYSIOLOGY TO IVF, BOLOGNA, ITALY (1997)
1995 HOLMES CH, SIMPSON KL, HOULIHAN JM, MCLAUGHLIN EA, FORD WCL, 'Targeted abrogation of resistance to complement in the female reproductive tract: Applications locally in cancer therapy and immunocontraception', IMMUNOCONTRACEPTION, UPPSALA, SWEDEN (1995)
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Grants and Funding

Summary

Number of grants 79
Total funding $30,253,936

Click on a grant title below to expand the full details for that specific grant.


20147 grants / $1,157,679

Chlamydia infection in males $630,558

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Eileen McLaughlin, Professor Kenneth Beagley
Scheme Project Grant
Role Lead
Funding Start 2014
Funding Finish 2014
GNo G1300117
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

miRNA regulation of sperm maturation $383,447

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Associate Professor Brett Nixon, Professor Eileen McLaughlin, Doctor Janet Holt
Scheme Project Grant
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1300125
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

JuLI Stage $71,674

Funding body: NHMRC (National Health & Medical Research Council)

The Role of the GTPase Dynamin in the Female Germline$30,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Ms Kate Redgrove, Doctor Janet Holt, Professor Eileen McLaughlin, Associate Professor Brett Nixon
Scheme Bridging Grant
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1301333
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

The role of dynamin is spermatogenesis and sperm-oocyte interactions$20,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Associate Professor Brett Nixon, Professor Eileen McLaughlin, Professor Adam McCluskey
Scheme Near Miss Grant
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1301400
Type Of Funding Internal
Category INTE
UON Y

Understanding the Effects of Persistent Chlamydia Infection in the Male Germline$20,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Ms Kate Redgrove, Professor Eileen McLaughlin
Scheme Project Grant
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1401440
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Faculty PVC Conference Assistance Grant 2014$2,000

Funding body: University of Newcastle - Faculty of Science & IT

Funding body University of Newcastle - Faculty of Science & IT
Project Team Professor Eileen McLaughlin
Scheme PVC Conference Assistance Grant
Role Lead
Funding Start 2014
Funding Finish 2014
GNo G1401229
Type Of Funding Internal
Category INTE
UON Y

20135 grants / $362,182

Novel function of heat shock protein 2A in the regulation of human sperm-egg interactions$292,182

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Associate Professor Brett Nixon, Laureate Professor John Aitken, Professor Eileen McLaughlin
Scheme Project Grant
Role Investigator
Funding Start 2013
Funding Finish 2013
GNo G1200193
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Chlamydia - Vaccine development to prevent adverse reproductive outcomes in males.$15,000

Funding body: University of Newcastle - Faculty of Science & IT

Funding body University of Newcastle - Faculty of Science & IT
Project Team Professor Eileen McLaughlin
Scheme Strategic Small Grant
Role Lead
Funding Start 2013
Funding Finish 2013
GNo G1401066
Type Of Funding Internal
Category INTE
UON Y

Dynamin - role in sperm oocyte interaction$10,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Eileen McLaughlin, Associate Professor Brett Nixon, Professor Adam McCluskey
Scheme Near Miss Grant
Role Lead
Funding Start 2013
Funding Finish 2013
GNo G1300483
Type Of Funding Internal
Category INTE
UON Y

Dynamin - role in sperm oocyte interaction$10,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor Eileen McLaughlin, Associate Professor Brett Nixon, Professor Adam McCluskey
Scheme Near Miss
Role Lead
Funding Start 2013
Funding Finish 2013
GNo G1300700
Type Of Funding External
Category EXTE
UON Y

20126 grants / $480,100

Role of Musashi in the regulation of cell cycle proteins$280,000

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Professor Eileen McLaughlin, Dr Gary Hime, Professor Margaret Fuller
Scheme Discovery Projects
Role Lead
Funding Start 2012
Funding Finish 2012
GNo G1100068
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Hedgehog Signalling in Spermatogenesis$150,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Dr Kate Loveland, Professor Eileen McLaughlin
Scheme Project Grant
Role Lead
Funding Start 2012
Funding Finish 2012
GNo G1101100
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

The effects of cigarette smoke on the reproductive health of offspring using our unique mouse model.$15,100

Funding body: University of Newcastle - Faculty of Science & IT

Funding body University of Newcastle - Faculty of Science & IT
Project Team Professor Eileen McLaughlin
Scheme Strategic Small Grant
Role Lead
Funding Start 2012
Funding Finish 2012
GNo G1401103
Type Of Funding Internal
Category INTE
UON Y

BMG SPECTROstar Nano$15,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Laureate Professor John Aitken, Professor Eileen McLaughlin, Ms Belinda Nixon, Doctor Shaun Roman, Doctor Mark Baker, Doctor Geoffry De Iuliis, Doctor Lisa Mitchell, Doctor Matthew Jobling
Scheme Equipment Grant
Role Investigator
Funding Start 2012
Funding Finish 2012
GNo G1100971
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

Ultrasonic Homogenizer System and -80 ºC Freezers for chemical and biological sample storage$10,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Adam McCluskey, Professor Eileen McLaughlin, Professor Peter Lewis, Ms Belinda Nixon, Doctor Shaun Roman, Doctor Jennette Sakoff, Doctor Ian Grainge
Scheme Equipment Grant
Role Investigator
Funding Start 2012
Funding Finish 2012
GNo G1100986
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

The role of miRNAs in the regulation of sperm maturation$10,000

Funding body: University of Newcastle - Faculty of Science & IT

Funding body University of Newcastle - Faculty of Science & IT
Project Team Associate Professor Brett Nixon, Professor Eileen McLaughlin, Doctor Natalie Beveridge
Scheme Strategic Initiative Research Fund (SIRF)
Role Investigator
Funding Start 2012
Funding Finish 2012
GNo G1401028
Type Of Funding Internal
Category INTE
UON Y

20117 grants / $1,849,961

Gamete-specific knockout of Fizzy-Related to examine its meiotic role in oocytes and sperm$600,000

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Professor Eileen McLaughlin, Conjoint Professor Keith Jones, Professor Sergio Moreno
Scheme Discovery Projects
Role Lead
Funding Start 2011
Funding Finish 2011
GNo G1000020
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Establishment of a comprehensive regional biophysical analysis facility $500,000

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Professor Peter Lewis, Professor Nicholas Dixon, Professor Eileen McLaughlin, Professor Adam McCluskey, Associate Professor Aaron Oakley, Laureate Professor Paul Foster, Laureate Professor John Aitken, Associate Professor Jennifer Beck, Dr Michael Kelso, Professor Graham Nicholson, Associate Professor Elizabeth Harry, Professor Ian Charles, Associate Professor Steven Djordjevic
Scheme Linkage Infrastructure Equipment & Facilities (LIEF)
Role Investigator
Funding Start 2011
Funding Finish 2011
GNo G1000630
Type Of Funding Scheme excluded from IGS
Category EXCL
UON Y

Chemical Biology$444,961

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Adam McCluskey, Doctor Warwick Belcher, Doctor Ian Grainge, Professor Christopher Grof, Professor Peter Lewis, Professor Eileen McLaughlin, Doctor Shaun Roman, Conjoint Professor Ray Rose, Doctor Jennette Sakoff, Doctor Nikki Verrills
Scheme Priority Research Centre
Role Investigator
Funding Start 2011
Funding Finish 2011
GNo G1100052
Type Of Funding Internal
Category INTE
UON Y

Establishment of a comprehensive regional biophysical analysis facility $230,000

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Professor Peter Lewis, Professor Nicholas Dixon, Professor Eileen McLaughlin, Professor Adam McCluskey, Associate Professor Aaron Oakley, Laureate Professor Paul Foster, Laureate Professor John Aitken, Associate Professor Jennifer Beck, Dr Michael Kelso, Professor Graham Nicholson, Associate Professor Elizabeth Harry, Professor Ian Charles, Associate Professor Steven Djordjevic
Scheme Linkage Infrastructure Equipment & Facilities (LIEF) Partner funding
Role Investigator
Funding Start 2011
Funding Finish 2011
GNo G1100484
Type Of Funding Scheme excluded from IGS
Category EXCL
UON Y

Towards a Chlamydia vaccine for males: The key role of mucosal IgA$35,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Kenneth Beagley, Professor Eileen McLaughlin
Scheme Project Grant
Role Lead
Funding Start 2011
Funding Finish 2011
GNo G0190618
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

SLX4 - a key regulator of male germ cell development and DNA repair$25,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor Eileen McLaughlin, Associate Professor Brett Nixon
Scheme Project Grant
Role Lead
Funding Start 2011
Funding Finish 2011
GNo G1001000
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Eppendorf mastercycler pro with thermomixer comfort and 5430R centrifuge$15,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Eileen McLaughlin, Professor Peter Lewis, Professor Adam McCluskey, Conjoint Professor Keith Jones, Associate Professor Brett Nixon, Doctor Shaun Roman, Doctor Jennette Sakoff, Doctor Ian Grainge, Doctor Janet Holt, Doctor Xiao Yang
Scheme Equipment Grant
Role Lead
Funding Start 2011
Funding Finish 2011
GNo G1100028
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

20109 grants / $4,003,154

Development of a humane non-surgical sterilization method for domestic animals$1,006,825

Funding body: Found Animals Foundation Inc

Funding body Found Animals Foundation Inc
Project Team Laureate Professor John Aitken, Professor Eileen McLaughlin, Professor Adam McCluskey
Scheme Michelson Grants in Reproductive Biology
Role Investigator
Funding Start 2010
Funding Finish 2010
GNo G0900113
Type Of Funding International - Competitive
Category 3IFA
UON Y

Feasibility of Humane Camel Management$892,250

Funding body: CRC for Invasive Animals

Funding body CRC for Invasive Animals
Project Team Laureate Professor John Aitken, Professor Eileen McLaughlin
Scheme Research Grant
Role Investigator
Funding Start 2010
Funding Finish 2010
GNo G1100665
Type Of Funding CRC - Cooperative Research Centre
Category 4CRC
UON Y

Sex Ratio and Sterility for Commercial animal production - round 5 Cluster$700,000

Funding body: CSIRO - Commonwealth Scientific and Industrial Research Organisation

Funding body CSIRO - Commonwealth Scientific and Industrial Research Organisation
Project Team Laureate Professor John Aitken, Professor Eileen McLaughlin, Doctor Shaun Roman
Scheme National Research Flagship Cluster
Role Investigator
Funding Start 2010
Funding Finish 2010
GNo G1000045
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

An Integrated LC-MS-NMR facility for Applications in Proteomics and Organic Chemistry$500,000

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Professor Adam McCluskey, Laureate Professor John Aitken, Professor Paul Dastoor, Professor Phillip Robinson, Professor Eileen McLaughlin, Emeritus Professor Geoffrey Lawrance, Professor Marcel Maeder, Professor Hugh Dunstan, Doctor Shaun Roman, Professor Rob Atkin, Doctor Clovia Holdsworth, Doctor Mark Baker, Doctor Nikki Verrills, Professor Gottfried Otting, Associate Professor Brett Nixon, Doctor Xiaojing Zhou, Ms Megan Chircop, Doctor Warwick Belcher
Scheme Linkage Infrastructure Equipment & Facilities (LIEF)
Role Investigator
Funding Start 2010
Funding Finish 2010
GNo G0190402
Type Of Funding Scheme excluded from IGS
Category EXCL
UON Y

Laser microdissection microscopy system for cell and development biology$350,000

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Professor Eileen McLaughlin, Conjoint Professor Keith Jones, Laureate Professor John Aitken, Associate Professor Brett Nixon, Doctor Shaun Roman, Professor Alan Brichta, Doctor Rick Thorne, Doctor Doug Smith, Associate Professor David McCurdy, Conjoint Professor Ray Rose, Professor Christopher Grof, Emeritus Professor Leonie Ashman, Professor Gordon Burns, Doctor Brett Graham, Associate Professor Paul Tooney, Professor Roger Smith, Laureate Professor Paul Foster, Professor Trevor Day, Professor Robert Callister
Scheme Linkage Infrastructure Equipment & Facilities (LIEF)
Role Lead
Funding Start 2010
Funding Finish 2010
GNo G0190369
Type Of Funding Scheme excluded from IGS
Category EXCL
UON Y

An Integrated LC-MS-NMR facility for Applications in Proteomics and Organic Chemistry$280,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Adam McCluskey, Laureate Professor John Aitken, Professor Paul Dastoor, Professor Phillip Robinson, Professor Eileen McLaughlin, Emeritus Professor Geoffrey Lawrance, Professor Marcel Maeder, Professor Hugh Dunstan, Doctor Shaun Roman, Professor Rob Atkin, Doctor Clovia Holdsworth, Doctor Mark Baker, Doctor Nikki Verrills, Professor Gottfried Otting, Associate Professor Brett Nixon, Doctor Xiaojing Zhou, Ms Megan Chircop, Doctor Warwick Belcher
Scheme Equipment Grant
Role Investigator
Funding Start 2010
Funding Finish 2010
GNo G1000873
Type Of Funding Internal
Category INTE
UON Y

Waters, Ultra high performance liquid chromatography system (nano-Aquity) $30,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Doctor Mark Baker, Laureate Professor John Aitken, Professor Adam McCluskey, Associate Professor Brett Nixon, Emeritus Professor John Rostas, Professor Eileen McLaughlin
Scheme Equipment Grant
Role Investigator
Funding Start 2010
Funding Finish 2010
GNo G1000051
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

Electron Multiplier Charge-Coupled Device Camera. Hamamatsu EM-CCD Camera C9100-13$29,079

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Keith Jones, Professor Eileen McLaughlin, Professor Dirk Van Helden, Doctor Rick Thorne
Scheme Equipment Grant
Role Investigator
Funding Start 2010
Funding Finish 2010
GNo G1000052
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

20098 grants / $2,307,489

The role of the Anaphase-Promoting Complex activator Cdh1 in mammalian oocytes and aneuploidy$506,250

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Keith Jones, Professor Eileen McLaughlin
Scheme Project Grant
Role Investigator
Funding Start 2009
Funding Finish 2009
GNo G0188850
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Characterization of the molecular basis of human sperm-oocyte interaction$474,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Associate Professor Brett Nixon, Professor Eileen McLaughlin, Dr M O'Bryan
Scheme Project Grant
Role Investigator
Funding Start 2009
Funding Finish 2009
GNo G0188867
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

RNA binding proteins Musashi: role in foliculogenesis and oocyte development$402,750

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Eileen McLaughlin, Dr Gary Hime
Scheme Project Grant
Role Lead
Funding Start 2009
Funding Finish 2009
GNo G0188862
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Confocal Laser Scanning Microscopy for Live Cell Imaging$275,000

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Conjoint Professor Keith Jones, Professor Eileen McLaughlin, Laureate Professor John Aitken, Conjoint Professor Ray Rose, Emeritus Professor John Patrick, Conjoint Professor Christina Offler, Associate Professor David McCurdy, Emeritus Professor Leonie Ashman, Professor Gordon Burns, Professor Dirk Van Helden, Doctor Nikki Verrills, Associate Professor Brett Nixon, Doctor Shaun Roman, Associate Professor Yong-Ling Ruan, Doctor Rick Thorne, Professor Mike Calford
Scheme Linkage Infrastructure Equipment & Facilities (LIEF)
Role Investigator
Funding Start 2009
Funding Finish 2009
GNo G0189038
Type Of Funding Scheme excluded from IGS
Category EXCL
UON Y

Aging eggs: understanding the molecular mechanisms of declining female fertility$79,489

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Conjoint Professor Keith Jones, Professor Eileen McLaughlin
Scheme Project Grant
Role Investigator
Funding Start 2009
Funding Finish 2009
GNo G0189795
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

LAS-4000 Chemiluminescence imaging system$25,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Eileen McLaughlin, Laureate Professor John Aitken, Professor Peter Lewis, Associate Professor Brett Nixon, Doctor Shaun Roman
Scheme Equipment Grant
Role Lead
Funding Start 2009
Funding Finish 2009
GNo G0189852
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

200810 grants / $7,465,033

Centre for Biotechnology and Development$6,420,000

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Laureate Professor John Aitken, Dr Gary Hime, Professor M Holland, Professor D Jans, Professor P Koopman, Dr Kate Loveland, Professor Eileen McLaughlin, Dr M O'Bryan, Doctor Shaun Roman, Assoc. Prof A Sinclair
Scheme ARC Centres of Excellence
Role Investigator
Funding Start 2008
Funding Finish 2008
GNo G0188624
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Xenobiotics - ocidative stress in the mammalian ovary$362,625

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Eileen McLaughlin, Associate Professor Brett Nixon, Doctor Shaun Roman
Scheme Project Grant
Role Lead
Funding Start 2008
Funding Finish 2008
GNo G0187620
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Centre for Biotechnology and Development$297,273

Funding body: NSW Department of State and Regional Development

Funding body NSW Department of State and Regional Development
Project Team Laureate Professor John Aitken, Dr Gary Hime, Professor M Holland, Professor D Jans, Professor P Koopman, Dr Kate Loveland, Professor Eileen McLaughlin, Dr M O'Bryan, Doctor Shaun Roman, Assoc. Prof A Sinclair
Scheme Centres of Excellence (Partner)
Role Investigator
Funding Start 2008
Funding Finish 2008
GNo G0189183
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Cellular signals controlling oocyte activation$270,000

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Professor Eileen McLaughlin, Dr Darryl Russell, Dr Rebecca Robker
Scheme Discovery Projects
Role Lead
Funding Start 2008
Funding Finish 2008
GNo G0187536
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

CEF Admin Relief McLaughlin$50,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Hugh Dunstan, Professor Eileen McLaughlin
Scheme Career Enhancement Fellowship for Academic Women
Role Investigator
Funding Start 2008
Funding Finish 2008
GNo G0189257
Type Of Funding Internal
Category INTE
UON Y

Understanding the aetiology of human male infertility: Elucidation of the mechanisms underpinning sperm-egg interaction$21,650

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Associate Professor Brett Nixon, Professor Eileen McLaughlin
Scheme Project Grant
Role Investigator
Funding Start 2008
Funding Finish 2008
GNo G0188465
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Characterization of the molecular basis of mouse sperm-oocyte interaction$18,285

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Associate Professor Brett Nixon, Professor Eileen McLaughlin
Scheme Near Miss Grant
Role Investigator
Funding Start 2008
Funding Finish 2008
GNo G0188405
Type Of Funding Internal
Category INTE
UON Y

Programmed mammalian oocyte activation: the production line model of primordial follicle development$14,700

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Eileen McLaughlin, Conjoint Professor Keith Jones
Scheme Pilot Grant
Role Lead
Funding Start 2008
Funding Finish 2008
GNo G0189084
Type Of Funding Internal
Category INTE
UON Y

Personal career development within the University of Newcastle in 2008$8,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Eileen McLaughlin
Scheme Career Enhancement Fellowship for Academic Women
Role Lead
Funding Start 2008
Funding Finish 2008
GNo G0188507
Type Of Funding Internal
Category INTE
UON Y

41st Annual Meeting of the Society for the Study of Reproduction $2,500

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Eileen McLaughlin
Scheme Travel Grant
Role Lead
Funding Start 2008
Funding Finish 2008
GNo G0188937
Type Of Funding Internal
Category INTE
UON Y

20079 grants / $669,867

FACSAria - Fluorescence activated cell sorter$300,000

Funding body: Cancer Institute NSW

Funding body Cancer Institute NSW
Project Team Doctor Nikki Verrills, Emeritus Professor Leonie Ashman, Laureate Professor John Aitken, Professor Eileen McLaughlin, Professor Alistair Sim, Doctor Rick Thorne, Doctor Jennette Sakoff
Scheme Research Infrastructure Grants
Role Investigator
Funding Start 2007
Funding Finish 2007
GNo G0187666
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Biotechnology applications in the veterinary pharmacuetical industry: Pharmacological manipulation of ovarian function in domestic animals$134,998

Funding body: Pestat Pty Ltd

Funding body Pestat Pty Ltd
Project Team Professor Eileen McLaughlin, Laureate Professor John Aitken
Scheme Linkage Projects Partner funding
Role Lead
Funding Start 2007
Funding Finish 2007
GNo G0188204
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Centre for Biotechnology and Development.$96,220

Funding body: NSW Department of State and Regional Development

Funding body NSW Department of State and Regional Development
Project Team Laureate Professor John Aitken, Dr Kate Loveland, Professor P Koopman, Assoc. Prof A Sinclair, Professor D De Krester, Dr M O'Bryan, Dr Gary Hime, Professor D Jans, Doctor Shaun Roman, Professor Eileen McLaughlin, Professor C Goodnow, Professor M Holland
Scheme Centres of Excellence (Partner)
Role Investigator
Funding Start 2007
Funding Finish 2007
GNo G0187937
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

HMRI Contribution toward FACSAria - Fluorescence activated cell sorter$52,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Nikki Verrills, Emeritus Professor Leonie Ashman, Laureate Professor John Aitken, Professor Eileen McLaughlin, Professor Alistair Sim, Doctor Rick Thorne, Doctor Jennette Sakoff
Scheme Equipment Grant
Role Investigator
Funding Start 2007
Funding Finish 2007
GNo G0188207
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

High speed/sensitivity CCD camera$30,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Dirk Van Helden, Professor Eileen McLaughlin, Professor Gordon Burns, Doctor Rick Thorne, Dr Marcus Howlett, Doctor Mohammad Imtiaz, Professor Alan Brichta, Professor Robert Callister, Doctor Brett Graham, Associate Professor Derek Laver, Associate Professor Liz Milward, Doctor John Holdsworth
Scheme Equipment Grant
Role Investigator
Funding Start 2007
Funding Finish 2007
GNo G0188196
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

Cytokines and Folliculogenesis$20,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Eileen McLaughlin
Scheme Near Miss Grant
Role Lead
Funding Start 2007
Funding Finish 2007
GNo G0187187
Type Of Funding Internal
Category INTE
UON Y

Chemokines and spermatogenesis: roles of SDF-1 and CXCR-4 in the establishment of spermatogenesis$20,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Eileen McLaughlin, Doctor Shaun Roman, Associate Professor Brett Nixon
Scheme Near Miss Grant
Role Lead
Funding Start 2007
Funding Finish 2007
GNo G0187197
Type Of Funding Internal
Category INTE
UON Y

Musashi 1 and 2 - role of RNA binding proteins in oocyte maturation$14,550

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Eileen McLaughlin
Scheme Pilot Grant
Role Lead
Funding Start 2007
Funding Finish 2007
GNo G0186712
Type Of Funding Internal
Category INTE
UON Y

2007 SRB Annual Scientific Conference to be held in cnjunction with the ESA, Christchurch Convention Centre, New Zealand, 2/9/2007 - 5/9/2007$2,099

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Eileen McLaughlin
Scheme Travel Grant
Role Lead
Funding Start 2007
Funding Finish 2007
GNo G0188058
Type Of Funding Internal
Category INTE
UON Y

20064 grants / $573,055

PRC - Priority Research Centre for Reproductive Science$544,282

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Laureate Professor John Aitken, Professor Roger Smith, Professor Eileen McLaughlin, Associate Professor Brett Nixon, Doctor Shaun Roman, Conjoint Associate Professor Vicki Clifton, Conjoint Professor Warwick Giles, Professor Jon Hirst, Conjoint Associate Professor Rick Nicholson, Professor Ian Symonds
Scheme Priority Research Centre
Role Investigator
Funding Start 2006
Funding Finish 2006
GNo G0186945
Type Of Funding Internal
Category INTE
UON Y

Environmental impacts on female fertility and the menopause$17,273

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor Eileen McLaughlin, Laureate Professor John Aitken, Doctor Shaun Roman
Scheme Research Grant
Role Lead
Funding Start 2006
Funding Finish 2006
GNo G0186620
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Cytokine signalling pathway and ovarian folliculogenesis$10,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Eileen McLaughlin, Dr Darryl Russell
Scheme Near Miss Grant
Role Lead
Funding Start 2006
Funding Finish 2006
GNo G0186066
Type Of Funding Internal
Category INTE
UON Y

American Society of Andrology 31st Annual Conference, April 8 -11, 2006$1,500

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Eileen McLaughlin
Scheme Travel Grant
Role Lead
Funding Start 2006
Funding Finish 2006
GNo G0186466
Type Of Funding Internal
Category INTE
UON Y

20053 grants / $224,726

SOCS-4 - modulation of cytokine and growth factor signalling in the mammalian ovary$10,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Eileen McLaughlin, Conjoint Associate Professor Renate Griffith
Scheme Project Grant
Role Lead
Funding Start 2005
Funding Finish 2005
GNo G0184635
Type Of Funding Internal
Category INTE
UON Y

Oolemmal receptors - the role of the tetraspanin CD151 in sperm-egg fusion$7,537

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Eileen McLaughlin, Emeritus Professor Leonie Ashman
Scheme Project Grant
Role Lead
Funding Start 2005
Funding Finish 2005
GNo G0184625
Type Of Funding Internal
Category INTE
UON Y

20046 grants / $1,655,790

Multifunctional confocal laser scanning microscope with time resolved and two photon imaging and fluorescence correlation capabilities $579,230

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team
Scheme Unknown
Role Lead
Funding Start 2004
Funding Finish 2004
GNo
Type Of Funding Not Known
Category UNKN
UON Y

Biotechnology applications in the veterinary pharmaceutical industry: Pharmacological manipulation of ovarian function in domestic animals$465,000

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Professor Eileen McLaughlin, Laureate Professor John Aitken, Dr J O'Brien
Scheme Linkage Projects
Role Lead
Funding Start 2004
Funding Finish 2004
GNo G0183627
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Biotechnology applications in the veterinary pharmacuetical industry: Pharmacological manipulation of ovarian function in domestic animals$298,368

Funding body: Jurox

Funding body Jurox
Project Team Professor Eileen McLaughlin, Laureate Professor John Aitken, Dr J O'Brien
Scheme Linkage Projects Partner funding
Role Lead
Funding Start 2004
Funding Finish 2004
GNo G0183816
Type Of Funding Not Known
Category UNKN
UON Y

High-Speed Confocal Microscope Live Cell Recording System$274,692

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Professor Dirk Van Helden, Laureate Professor John Aitken, Professor Eileen McLaughlin, Professor Alan Brichta, Associate Professor J Keast, Dr J Brock, Dr S Head
Scheme Linkage Infrastructure Equipment & Facilities (LIEF)
Role Investigator
Funding Start 2004
Funding Finish 2004
GNo G0183031
Type Of Funding Scheme excluded from IGS
Category EXCL
UON Y

High-speed Confocal Microscope Live Cell Recording System$30,000

Funding body: University of New South Wales

Funding body University of New South Wales
Project Team Professor Dirk Van Helden, Associate Professor J Keast, Laureate Professor John Aitken, Dr J Brock, Professor Eileen McLaughlin, Dr S Head, Professor Alan Brichta
Scheme Linkage Infrastructure Equipment & Facilities (LIEF) Partner funding
Role Investigator
Funding Start 2004
Funding Finish 2004
GNo G0183841
Type Of Funding Not Known
Category UNKN
UON Y

Activation of the mammalian primordial follicle.$8,500

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Eileen McLaughlin
Scheme Project Grant
Role Lead
Funding Start 2004
Funding Finish 2004
GNo G0183443
Type Of Funding Internal
Category INTE
UON Y

20034 grants / $9,492,900

Centre for Biotechnology and Development.$9,458,900

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Laureate Professor John Aitken, Dr Kate Loveland, Professor P Koopman, Assoc. Prof A Sinclair, Professor D De Krester, Dr M O'Bryan, Dr Gary Hime, Professor D Jans, Doctor Shaun Roman, Professor Eileen McLaughlin, Professor C Goodnow, Professor M Holland
Scheme ARC Centres of Excellence
Role Investigator
Funding Start 2003
Funding Finish 2003
GNo G0182214
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

The role of cytokines in the activation of the ovarian follicle.$17,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor Eileen McLaughlin, Laureate Professor John Aitken
Scheme Research Grant
Role Lead
Funding Start 2003
Funding Finish 2003
GNo G0182197
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Oolemmal Proteomics - identification of oocyte cell surface protein complexes involved in sperm-egg interaction$12,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Eileen McLaughlin, Laureate Professor John Aitken
Scheme Project Grant
Role Lead
Funding Start 2003
Funding Finish 2003
GNo G0182320
Type Of Funding Internal
Category INTE
UON Y

Profiling germ cell gene expression during spermatogonial differentiation$5,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Doctor Shaun Roman, Professor Eileen McLaughlin
Scheme Project Grant
Role Investigator
Funding Start 2003
Funding Finish 2003
GNo G0182402
Type Of Funding Internal
Category INTE
UON Y

20021 grants / $12,000

Oocyte selection in the female germ line - survival of the fittest?$12,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Eileen McLaughlin
Scheme New Staff Grant
Role Lead
Funding Start 2002
Funding Finish 2002
GNo G0182024
Type Of Funding Internal
Category INTE
UON Y
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Research Supervision

Number of supervisions

Completed16
Current6

Total current UON EFTSL

PhD1.05

Current Supervision

Commenced Level of Study Research Title / Program / Supervisor Type
2015 PhD Chlamydial Infection in Males - is it a Significant Problem?
Biological Sciences, Faculty of Science and Information Technology, The University of Newcastle
Principal Supervisor
2013 PhD The Impact of Maternal Ageing and Chemotoxicants on Female Fertility
Biological Sciences, Faculty of Science and Information Technology, The University of Newcastle
Co-Supervisor
2012 PhD Hedgehog Signaling Pathway Inhibitors as Cancer Suppressing Agents
Biological Sciences, Faculty of Science and Information Technology, The University of Newcastle
Co-Supervisor
2007 Honours Musashi 1 and 2 RNA binding proteins role in mammalian folliculogenesis
Biol Sc Not Elsewhere Classifd, University of Newcastle
Principal Supervisor
2007 Honours Chemokines and spermatogenesis
Biol Sc Not Elsewhere Classifd, University of Newcastle
Co-Supervisor
2007 Honours Oxidiative stress and Folliculogenesis
Biol Sc Not Elsewhere Classifd, University of Newcastle
Principal Supervisor

Past Supervision

Year Level of Study Research Title / Program / Supervisor Type
2015 PhD A Focus on the Essential Roles of the Musashi Family of RNA Binding Proteins during Mammalian Spermatogenesis
Biological Sciences, Faculty of Science and Information Technology, The University of Newcastle
Principal Supervisor
2015 PhD Susceptibility of Mammalian Oocytes to Chromosome Segregation Errors with Maternal Aging
Human Biology, Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2013 PhD Regulation of the Transition from Gonocytes to Spermatogonia
Biological Sciences, Faculty of Science and Information Technology, The University of Newcastle
Principal Supervisor
2013 PhD Translational Control of Mouse Folliculogenesis and Oocyte Development
Biological Sciences, Faculty of Science and Information Technology, The University of Newcastle
Principal Supervisor
2013 PhD New Insights into the Molecular Basis of Human Sperm-Egg Interaction
Biological Sciences, Faculty of Science and Information Technology, The University of Newcastle
Co-Supervisor
2012 PhD Xenobiotics; Effects on Female Fertility
Biological Sciences, Faculty of Science and Information Technology, The University of Newcastle
Principal Supervisor
2008 PhD Oolemmal Proteomics: Identification of Oocyte Cell Surface Protein Complexes Involved in Murine Fertilisation
Biological Sciences, Faculty of Science and Information Technology, The University of Newcastle
Principal Supervisor
2006 PhD Non-Surgical Sterilisation of Female Domesticated Animals
Biological Sciences, Faculty of Science and Information Technology, The University of Newcastle
Principal Supervisor
2006 PhD Gene Expression During Development of the Mammalian Ovarian Primordial Follicle
Biological Sciences, Faculty of Science and Information Technology, The University of Newcastle
Principal Supervisor
2005 Honours Non genomic action of progesterone in human spermatozoa
Biol Sc Not Elsewhere Classifd, University of Newcastle
Principal Supervisor
2005 PhD The Molecular Basis of Sperm-Oocyte Interaction in the Mouse
Biological Sciences, Faculty of Science and Information Technology, The University of Newcastle
Co-Supervisor
2005 Honours Xenobiotics Effects on mammalian folliculogenesis
Biol Sc Not Elsewhere Classifd, University of Newcastle
Co-Supervisor
2004 PhD The role of Kit Ligand in primordial follicle activation in the juvenile rabbit ovary
Biol Sc Not Elsewhere Classifd, Australian National University
Consultant Supervisor
2004 Masters A novel GTPase activating protein RhGAPs in the male gamete
Biol Sc Not Elsewhere Classifd, University of Newcastle
Co-Supervisor
2004 Honours Supressors of Cytokine Signalling
Biol Sc Not Elsewhere Classifd, University of Newcastle
Principal Supervisor
2003 Honours Characterisation of the sperm progesterone receptor
Biol Sc Not Elsewhere Classifd, University of Newcastle
Co-Supervisor
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News

Smoking and male fertility breakthrough finding

October 1, 2014

Mothers who smoke while they are pregnant or breast feeding may be damaging the future fertility of their sons, according to breakthrough findings from University of Newcastle researchers published today.

Professor Eileen McLaughlin

Position

Pro Vice-Chancellor (Interim)
PVC Unit FSCIT
Office PVC - Science and Information Technology
Faculty of Science and Information Technology

Focus area

Biological Sciences

Contact Details

Email eileen.mclaughlin@newcastle.edu.au
Phone (02) 4921 5906
Mobile 0437 091293
Fax (02) 4921 7949

Office

Room V201A FSCIT PVC Unit
Building Mathematics
Location Callaghan
University Drive
Callaghan, NSW 2308
Australia
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