Profile Image

Professor Eileen McLaughlin

Pro Vice-Chancellor (Interim)

Office PVC - Science and Information Technology (Biological Sciences)

A good egg

The mysteries of conception are this researcher's passion. As a young biologist, Professor Eileen McLaughlin produced her first test tube baby in 1983, just five years after Louise Brown was heralded as the world's first IVF birth.

Professor Eileen McLaughlin in the laboratory 

It was a case of 'right time, right place' for McLaughlin, who graduated from the University of Glasgow to research positions involving assisted reproduction at the universities of Birmingham and Bristol at a time when Britain was the international hot spot in this emerging field.

That experience was the foundation for what has become a distinguished research career in reproductive science. McLaughlin's work has been recognised with awards from the British Fertility Society and the Society for Reproductive Biology in Australia and has been published in esteemed medical journals including Cell and The Lancet.

Since joining the University's reproductive science group in 2001, a focus of McLaughlin's research has been the fertility prospects of older women.

She says her research has reinforced the theory that declining egg quality, rather than quantity, is the major hindrance to conception in women in their late 30s and older.

While science has not delivered a magic formula to improve the quality of mature eggs, McLaughlin is researching the way oocytes, or immature egg cells, are 'woken' to be released from the ovary. The aim is that better understanding this process could lead to new ways of harvesting or prolonging the life of good eggs.

"The attrition rate of eggs is very high," she says. "A female has about 1 million eggs at birth but by the time she is in her mid 30s she is down to about 20,000.  By the age of 40, she will have a few thousand," she says.

"She will only ovulate 400 eggs in her life, so the vast majority of them are wasted. The challenge is to find a way to a hold on to some of those good eggs longer."

McLaughlin's work has established that many chemicals used in everyday items such as glues, dyes and pesticides, are potentially toxic to eggs, which can further frustrate the efforts of older mothers to conceive.
Professor Eileen McLaughlin with a microscope
"There are increasing numbers of women in their 30s who are having difficulty producing a sufficient number of good eggs to conceive. The evidence suggests that this may be influenced by lifetime exposure, probably at very low levels, to environmental toxicants," she says.

Exposure to these chemicals is a consequence of living in the modern world and McLaughlin says little can be done to reduce women's susceptibility. But the research underpins the importance of her work in trying to extend the life of healthy oocytes and improve outcomes for couples trying to conceive later in life.

Professor Eileen McLaughlin researches in collaboration with the Hunter Medical Research Institute's (HMRI) Pregnancy and Reproduction Program.  HMRI is a partnership between the University, Hunter New England Local Health District and the community.

Visit the Centre for Reproductive Science website

Visit the HMRI website

Eileen McLaughlin in a laboratory

A good egg

Biologist Professor Eileen McLaughlin is looking into the mysteries of conception.

Read more

Career Summary

Biography

I undertook a PhD at the University of Bristol on the effects of cryopreservation on human gametes and embryos under the supervision of Dr Chris Ford. On completion of my PhD I moved to the Department of Biochemistry on a Wellcome Trust postdoctoral fellowship to work in the lab of Prof Len Hall where I identified genes involved in male fertility and characterised their role in fertilization. In 2000 I took up a position in the Pest Animal Control CRC in CSIRO Sustainable Ecosystems in Canberra where I worked on the development of virally vectored immunocontraception for rabbit control. In 2002 I was recruited to the University of Newcastle where I established my research group. Work in my lab focuses on the RNA binding proteins and their roles in spermatogenesis and folliculogenesis and proteins involved in meiosis. In addition we study cytokines that control the activation of primordial follicles in the mammalian ovary and ovotoxic xenobiotics which cause oocyte loss and early menopause. I have published in Cell Stem Cell, PNAS, Developmental Biology and Toxicological Sciences . We use a number of mouse models and a wide range of cell and molecular biology techniques to monitor cell signalling dynamics in primary culture, identify novel target proteins, functionally characterise translational repressors and activators and use structural modelling to design inhibitors of these interactions. We collaborate extensively through the ARC Centre of Excellence in Biotechnology and Development as well as with individual groups in the USA and Australia.

Research Expertise
My research in the field of testicular biology has focused on spermatogonial development with particular emphasis on the identification and characterization of key regulators of spermatogonial stem cell replication (HOW), microRNA in germ cells, stem cell maintenance (Musashi), and male germ cell differentiation (c-Kit) and sperm function (Fertilin) (see McIver et al 2012 Human Reproduction Update, Monk et al 2010 Cell Stem Cell, Monk et al PLoS One 2012, Siddall et al 2006 PNAS, Prahbu et al 2006 Reproduction, McLaughlin et al 2001 Molecular Human Reproduction). In addition we study cytokines that control the activation of primordial follicles in the mammalian ovary and ovotoxic xenobiotics which cause oocyte loss and early menopause ( see Sutherland et al 2012 J Cellular Physiology, Sobinoff et al 2012, 2011, 2010 Toxicological Sciences, Blackmore et al 2004 Biology of Reproduction, Holt et al 2006 Developmental Biology, Hutt et al 2006 Biology of Reproduction, McLaughlin & McIver Reproduction 2009). In addition my lab has contributed to cell and molecular research in human and animal assisted reproduction with an emphasis on the characterization of gene and protein expression and function in male and female gametogenesis, reproductive tracts, roles in fertilization and as contraceptive targets (McLaughlin et al 2001, Asquith et al 2004, 2005, Nixon et al 2007, 2009, McLaughlin et al 2010, Redgrove et al 2011, Walker et al 2011).

Teaching Expertise
Senior Lecturer, Tutor & Demonstrator in Cell and Molecular Biology, Biochemistry, Immunobiology and Biotechnology (1000,2000 and 3000level) Implementation first ever Web-based delivery of all Level 1000 courses via Blackboard. Overseeing implementation of on-line assessments, and simulated laboratory computer experiments. Implementation Turnitin anti-plagiarism and collusion educational software for BIOL1000 cohort (2004). Awarded Graduate Certificate in Tertiary Teaching University of Newcastle 2006

Administrative Expertise
University Expertise Animal Ethics Committee Member Deputy Head of School of Environmental & Life Sciences Institutional Biosafety Committee Member ERA Cluster 8 committee member Animal Ethics Review Committee Member Faculty of Science Research and Research Training Committee Member Manager and Instructor-in-charge of Imaging Suite, Life Sciences Building (2001 - present) Chair of School Committee Review of Induction Materials for Honours students (2002 - 3) School Representative for Faculty of Science & IT International Committee (2004 - 2005) Biological Sciences Representative for School Research Higher Degree Progress Committee (2003 - present) Coordinator Level 1000 Biology - 500 students and 50 staff and Level 2000 Biology - 100 students and 10 staff Professional Activities Reviewer Grant Giving Bodies: NHMRC GRP member, Medical Research Council UK, the Biotechnology & Biological Sciences Research Council UK, and the Wellcome Trust. I also review for a number of specialist Reproduction journals. Positions in Learned Societies: President elect of Society for Reproductive Biology, Chairman of the British Andrology Society (1997-2000) and a Director of the Journal of Reproduction & Fertility (Ltd.). Committee member: British Fertility Society Association of Clinical Embryologists, Society for Reproductive Biology and the Society for Low Temperature Biology. Editor: multiple peer reviewed clinical guidelines and am an adviser to the United States of America Congress, Office of Technology Assessment and the UK Government Department of Health and the Human Fertilization and Embryology Authority.

Collaborations
Collaborators include: Dr Shaun Roman, Dr Brett Nixon, Prof John Aitken, Prof Adam McCluskey (University of Newcastle) Prof Keith Jones, Dr Janet Holt and Dr Julie Merriman Jones (University of Newcastle) Dr Gary Hime (University of Melbourne) and Prof Minx Fuller (Standford University) Prof Kate Loveland & Prof Moira O'Bryan (Monash University) Dr Darryl Russell and Dr Rebecca Robker (University of Adelaide) Prof Peter Koopman and Dr Jo Bowles (University of Queensland) Prof Ken Beagley (QUT) & Dr C Wira (Dartmouth University)


Qualifications

  • PhD, University of Bristol
  • Bachelor of Science (Honours), University of Glasgow - Scotland

Keywords

  • Biochemistry
  • Biology
  • Biotechnology
  • Immunobiology
  • Ovarian Biology
  • Reproductive Sciences
  • Spermatogonial Stem Cells

Fields of Research

CodeDescriptionPercentage
060199Biochemistry and Cell Biology not elsewhere classified55
060699Physiology not elsewhere classified30
111499Paediatrics and Reproductive Medicine not elsewhere classified15

Professional Experience

UON Appointment

DatesTitleOrganisation / Department
1/01/2014 - ProfessorUniversity of Newcastle
School of Environmental and Life Sciences
Australia
11/09/2008 - 25/09/2008Casual AcademicUniversity of Newcastle
School of Environmental and Life Sciences
Australia

Academic appointment

DatesTitleOrganisation / Department
1/04/2010 - ProfessorUniversity of Newcastle
School of Environmental and Life Sciences
Australia
1/07/2008 - 1/04/2010Associate ProfessorUniversity of Newcastle
School of Environmental and Life Sciences
Australia
1/01/2005 - 1/06/2008Senior LecturerUniversity of Newcastle
School of Environmental and Life Sciences
Australia
1/11/2001 - 1/12/2004LecturerUniversity of Newcastle
School of Environmental and Life Sciences
Australia

Membership

DatesTitleOrganisation / Department
Programme Committee MemberSociety for Reproductive Biology
Australia

Invitations

Participant

YearTitle / Rationale
2005Primordial follicle activation and development
Organisation: University of Adelaide
Edit

Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Chapter (7 outputs)

YearCitationAltmetricsLink
2013Sutherland JM, McLaughlin EA, Hime GR, Siddall NA, 'The Musashi family of RNA binding proteins: master regulators of multiple stem cell populations.', Transcriptional and Translational Regulation of Stem Cells, Springer, Dordrecht 233-245 (2013) [B1]
DOI10.1007/978-94-007-6621-1_13
CitationsScopus - 4Web of Science - 3
2012Sobinoff AP, Bernstein IR, McLaughlin EA, 'All your eggs in one basket: Mechanisms of xenobiotic induced female reproductive senescence', Senescence, InTech Press, Rijeka 559-584 (2012) [B1]
2010McLaughlin EA, Sobinoff AP, 'Contraception targets in mammalian ovarian development', Fertility Control, Springer, Berlin 45-66 (2010) [B1]
CitationsScopus - 3
2009McLaughlin EA, Pacey AA, 'Cryopreservation and storage of spermatozoa', Textbook of Assisted Reproductive Technologies: Laboratory and Clinical Perspectives, Informa Healthcare, London 311-321 (2009) [B2]
2004McLaughlin EA, 'Cryopreservation and storage of spermatozoa', Textbook of Assisted Reproductive Techniques: Laboratory and Clinical Perspectives, Taylor & Francis, London 297-307 (2004) [B2]
2002McLaughlin EA, Holland M, 'Developing Immunocontraceptives', Assisted Reproductive Technology: Accomplishments and New Horizons, Cambridge University Press, Cambridge, UK 355-365 (2002) [B1]
2001McLaughlin EA, 'Cryopreservation & storage of sperm', , Martin Dunitz, London, 261-272 (2001) [B1]
Show 4 more chapters

Journal article (110 outputs)

YearCitationAltmetricsLink
2015Sobinoff AP, Dando SJ, Redgrove KA, Sutherland JM, Stanger SJ, Armitage CW, et al., 'Chlamydia muridarum infection-induced destruction of male germ cells and sertoli cells is partially prevented by Chlamydia major outer membrane protein-specific immune CD4 cells.', Biol Reprod, 92 27 (2015)
DOI10.1095/biolreprod.114.124180Author URL
2015Sutherland JM, Siddall NA, Hime GR, McLaughlin EA, 'RNA binding proteins in spermatogenesis: an in depth focus on the Musashi family.', Asian J Androl, 17 529-536 (2015)
DOI10.4103/1008-682X.151397Author URL
2015Nixon B, Bromfield EG, Dun MD, Redgrove KA, McLaughlin EA, Aitken RJ, 'The role of the molecular chaperone heat shock protein A2 (HSPA2) in regulating human sperm-egg recognition.', Asian J Androl, 17 568-573 (2015)
DOI10.4103/1008-682X.151395Author URL
Co-authorsJohn Aitken, Matt Dun, Brett Nixon
2015Sutherland JM, Sobinoff AP, Fraser BA, Redgrove KA, Davidson TL, Siddall NA, et al., 'RNA binding protein Musashi-1 directly targets Msi2 and Erh during early testis germ cell development and interacts with IPO5 upon translocation to the nucleus.', FASEB J, 29 2759-2768 (2015)
DOI10.1096/fj.14-265868Author URL
2015Reid AT, Anderson AL, Roman SD, McLaughlin EA, McCluskey A, Robinson PJ, et al., 'Glycogen synthase kinase 3 regulates acrosomal exocytosis in mouse spermatozoa via dynamin phosphorylation.', FASEB J, 29 2872-2882 (2015)
DOI10.1096/fj.14-265553Author URL
Co-authorsJohn Aitken, Adam Mccluskey, Shaun Roman, Brett Nixon
2014Robker RL, Watson LN, Robertson SA, Dunning KR, McLaughlin EA, Russell DL, 'Identification of sites of STAT3 action in the female reproductive tract through conditional gene deletion', PLoS ONE, 9 (2014) [C1]

The STAT3 transcription factor is a pleiotropic transducer of signalling by hormones, growth factors and cytokines that has been identified in the female reproductive tract from oocytes and granulosa cells of the ovary to uterine epithelial and stromal cells. In the present study we used transgenic models to investigate the importance of STAT3 for reproductive performance in these different tissues. The Cre-LoxP system was used to delete STAT3 in oocytes by crossing Stat3 fl/fl with Zp3-cre+ mice, or in ovarian granulosa cells and uterine stroma by crossing with Amhr2-Cre+ mice. Surprisingly, deletion of STAT3 in oocytes had no effect on fertility indicating that the abundance of STAT3 protein in maturing oocytes and fertilized zygotes is not essential to these developmental stages. In Stat3fl/fl;Amhr2-cre + females impaired fertility was observed through significantly fewer litters and smaller litter size. Ovulation rate, oocyte fertilization and development to blastocyst were unaffected in this line; however, poor recombination efficiency in granulosa cells had yielded no net change in STAT3 protein abundance. In contrast, uteri from these mice showed STAT3 protein depletion selectively from the stomal compartment. A significant reduction in number of viable fetuses on gestational day 18, increased fetal resorptions and disrupted placental morphology were evident causes of the reduced fertility. In conclusion, this study defines an important role for STAT3 in uterine stromal cells during embryo implantation and the development of a functional placenta. © 2014 Robker et al.

DOI10.1371/journal.pone.0101182
2014Redgrove KA, McLaughlin EA, 'The role of the immune response in chlamydia trachomatis infection of the male genital tract: A double-edged sword', Frontiers in Immunology, 5 1-22 (2014) [C1]
DOI10.3389/fimmu.2014.00534
CitationsScopus - 1Web of Science - 1
2014Camlin NJ, McLaughlin EA, Holt JE, 'Through the smoke: Use of in vivo and in vitro cigarette smoking models to elucidate its effect on female fertility', Toxicology and Applied Pharmacology, 281 266-275 (2014) [C1]

A finite number of oocytes are established within the mammalian ovary prior to birth to form a precious ovarian reserve. Damage to this limited pool of gametes by environmental factors such as cigarette smoke and its constituents therefore represents a significant risk to a woman's reproductive capacity. Although evidence from human studies to date implicates a detrimental effect of cigarette smoking on female fertility, these retrospective studies are limited and present conflicting results. In an effort to more clearly understand the effect of cigarette smoke, and its chemical constituents, on female fertility, a variety of in vivo and in vitro animal models have been developed. This article represents a systematic review of the literature regarding four of experimental model types: 1) direct exposure of ovarian cells and follicles to smoking constituents' in vitro, 2) direct exposure of whole ovarian tissue with smoking constituents in vitro, 3) whole body exposure of animals to smoking constituents and 4) whole body exposure of animals to cigarette smoke. We summarise key findings and highlight the strengths and weaknesses of each model system, and link these to the molecular mechanisms identified in smoke-induced fertility changes.

DOI10.1016/j.taap.2014.10.010
Co-authorsJanet Holt
2014Holt JE, Pye V, Boon E, Stewart JL, Garcia-Higuera I, Moreno S, et al., 'The APC/C activator FZR1 is essential for meiotic prophase I in mice', DEVELOPMENT, 141 1354-U327 (2014) [C1]
DOI10.1242/dev.104828Author URL
CitationsScopus - 1Web of Science - 1
Co-authorsJanet Holt, Keith Jones
2014Yun Y, Holt JE, Lane SIR, McLaughlin EA, Merriman JA, Jones KT, 'Reduced ability to recover from spindle disruption and loss of kinetochore spindle assembly checkpoint proteins in oocytes from aged mice', Cell Cycle, 13 1938-1947 (2014) [C1]

Currently, maternal aging in women, based on mouse models, is thought to raise oocyte aneuploidy rates, because chromosome cohesion deteriorates during prophase arrest, and Sgo2, a protector of centromeric cohesion, is lost. Here we show that the most common mouse strain, C57Bl6/J, is resistant to maternal aging, showing little increase in aneuploidy or Sgo2 loss. Instead it demonstrates significant kinetochore-associated loss in the spindle assembly checkpoint protein Mad2 and phosphorylated Aurora C, which is involved in microtubule-kinetochore error correction. Their loss affects the fidelity of bivalent segregation but only when spindle organization is impaired during oocyte maturation. These findings have an impact clinically regarding the handling of human oocytes ex vivo during assisted reproductive techniques and suggest there is a genetic basis to aneuploidy susceptibility. © 2014 Landes Bioscience.

DOI10.4161/cc.28897
CitationsScopus - 3Web of Science - 2
Co-authorsKeith Jones, Janet Holt
2014Trinh TN, McLaughlin EA, Gordon CP, McCluskey A, 'Hedgehog signalling pathway inhibitors as cancer suppressing agents', MedChemComm, 5 117-133 (2014) [C1]

The Hedgehog (Hh) signalling pathway plays a pivotal role in the spatial and temporal regulation of cell proliferation and differentiation. By controlling the correct maturation of developing tissues and ensuring attainment of the correct size, position and the presence of fully functioning cellular structures, the Hh plays a pivotal role in development. Conversely aberrant Hh signalling is involved in Gorlin syndrome, basal cell carcinoma (the most common cancer in the world), and more than one third of all human medulloblastoma cases. In all of these cases, it is believed that deregulated Hh signalling leads to increased cell proliferation and tumour formation. Inhibition of the Hedgehog signalling pathway, is a recently validated anti-cancer drug target, with vismodegib (Erivedge¿), approved by the U.S. Food and Drug Administration for the treatment of adult basal cell carcinoma. In this perspective we outline the current state of Hh pathway inhibitors with a particular focus on potential limitations of upstream Hh pathway inhibition in relation to resistance mutations and crosstalk pathways. Together, these limitations indicate that inhibition of downstream components, specifically the Gli family of transcription factors, may represent a next generation approach to suppress tumours associated with aberrant Hh pathway signalling. © 2014 The Royal Society of Chemistry.

DOI10.1039/c3md00334e
CitationsScopus - 5Web of Science - 4
Co-authorsAdam Mccluskey
2014Sahin Z, Szczepny A, Mclaughlin EA, Meistrich ML, Zhou W, Ustunel I, Loveland KL, 'Dynamic Hedgehog signalling pathway activity in germline stem cells', Andrology, 2 267-274 (2014) [C1]

Summary: Although the contribution of Hedgehog (Hh) signalling to stem cell development and oncogenesis is well recognised, its importance for spermatogonial stem cells (SSCs) has not been established. Here we interrogate adult rat SSCs using an established model in which only undifferentiated spermatogonial cells remain in the testis at 15 weeks following irradiation, and spermatogonial differentiation is induced within 4 weeks by gonadotrophin-releasing hormone antagonist (GnRH-ant) administration. Synthesis of Hh pathway components in untreated adult rat testes was compared with that in irradiated testes prior to and after GnRH-ant exposure using in situ hybridization. In adult testes with complete spermatogenesis, the Desert Hedgehog ligand transcript, Dhh, was detected in Sertoli cells, some spermatogonia and in spermatocytes by in situ hybridization. Spermatogenic cells were identified as sites of Hh signalling through detection of transcripts encoding the Hh receptor, Ptc2 transcripts and proteins for the key downstream target of Hh signalling, Gli1 and the Hh transcriptional activator, Gli2. Remarkably, the undifferentiated spermatogonia present in irradiated adult rat testes contained Dhh in addition to Ptc2, Gli1 and Gli2, revealing the potential for an autocrine Hh signalling loop to sustain undifferentiated spermatogonial cells. These transcripts became undetectable by in situ hybridization following GnRH-ant induction of spermatogonial differentiation, however, detection of Gli1 protein in spermatogonia in all groups indicates that Hh signalling is sustained. This is the first evidence of active Hh signalling in mammalian male germline stem cells, as has been documented for some cancer stem cells. © 2014 American Society of Andrology and European Academy of Andrology.

DOI10.1111/j.2047-2927.2014.00187.x
2014Sutherland JM, Fraser BA, Sobinoff AP, Pye VJ, Davidson TL, Siddall NA, et al., 'Developmental expression of Musashi-1 and Musashi-2 RNA-binding proteins during spermatogenesis: analysis of the deleterious effects of dysregulated expression.', Biol Reprod, 90 92 (2014) [C1]
DOI10.1095/biolreprod.113.115261Author URL
2014Redgrove KA, McLaughlin EA, 'The Role of the Immune Response in Chlamydia trachomatis Infection of the Male Genital Tract: A Double-Edged Sword.', Front Immunol, 5 534 (2014)
DOI10.3389/fimmu.2014.00534Author URL
2014Sobinoff AP, Sutherland JM, Beckett EL, Stanger SJ, Johnson R, Jarnicki AG, et al., 'Damaging legacy: maternal cigarette smoking has long-term consequences for male offspring fertility.', Hum Reprod, 29 2719-2735 (2014) [C1]
DOI10.1093/humrep/deu235Author URL
CitationsScopus - 2Web of Science - 2
Co-authorsAdam Mccluskey, Philip Hansbro
2013McIver SC, Roman SD, Nixon B, McLaughlin EA, Loveland KL, 'The rise of testicular germ cell tumours: The search for causes, risk factors and novel therapeutic targets [v1; ref status: Indexed, http://f1000r.es/md]', F1000 Research, 2 1-12 (2013) [C1]
DOI10.12688/f1000research.2-55.v2
Co-authorsShaun Roman, Brett Nixon
2013McIver SM, Roman SD, Nixon B, Loveland KL, McLaughlin EA, 'The rise of testicular germ cell tumours: the search for causes, risk factors and novel therapeutic targets', F1000Research, 2:55 (doi: 10.12688/f1000research.2-55.v1) 55-66 (2013)
CitationsScopus - 1
Co-authorsBrett Nixon, Shaun Roman
2013Merriman JA, Lane SIR, Holt JE, Jennings PC, Garcia-Higuera I, Moreno S, et al., 'Reduced Chromosome Cohesion Measured by Interkinetochore Distance Is Associated with Aneuploidy Even in Oocytes from Young Mice', Biology of Reproduction, 88 31-31 (2013) [C1]
DOI10.1095/biolreprod.112.104786
CitationsScopus - 4Web of Science - 4
Co-authorsJanet Holt, Keith Jones
2013Sobinoff AP, Beckett EL, Jarnicki AG, Sutherland JM, McCluskey A, Hansbro PM, McLaughlin EA, 'Scrambled and fried: Cigarette smoke exposure causes antral follicle destruction and oocyte dysfunction through oxidative stress', TOXICOLOGY AND APPLIED PHARMACOLOGY, 271 156-167 (2013) [C1]
DOI10.1016/j.taap.2013.05.009Author URL
CitationsScopus - 8Web of Science - 7
Co-authorsAdam Mccluskey, Philip Hansbro
2013Davies RG, Wagstaff KM, McLaughlin EA, Loveland KL, Jans DA, 'The BRCA1-binding protein BRAP2 can act as a cytoplasmic retention factor for nuclear and nuclear envelope-localizing testicular proteins', Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1833 3436-3444 (2013) [C1]
DOI10.1016/j.bbamcr.2013.05.015
CitationsScopus - 2Web of Science - 1
2013Loveland KL, McLaughlin EA, 'Hidden gems in the niche: a new approach to the study of spermatogonial stem cells', ASIAN JOURNAL OF ANDROLOGY, 15 214-215 (2013) [C3]
DOI10.1038/aja.2012.150Author URL
2013Redgrove KA, Anderson AL, McLaughlin EA, O'Bryan MK, Aitken RJ, Nixon B, 'Investigation of the mechanisms by which the molecular chaperone HSPA2 regulates the expression of sperm surface receptors involved in human spermoocyte recognition', MOLECULAR HUMAN REPRODUCTION, 19 120-135 (2013) [C1]
DOI10.1093/molehr/gas064Author URL
CitationsScopus - 15Web of Science - 15
Co-authorsJohn Aitken, Brett Nixon
2013Sobinoff AP, Sutherland JM, Mclaughlin EA, 'Intracellular signalling during female gametogenesis', Molecular Human Reproduction, 19 265-278 (2013) [C1]

Female reproductive potential is dictated by the size of the primordial follicle pool and the correct regulation of oocyte maturation and activation-events essential for production of viable offspring. Although a substantial body of work underpins our understanding of these processes, the molecular mechanisms of follicular and oocyte development are not fully understood. This review summarizes recent findings which have improved our conception of how folliculogenesis and oocyte competence are regulated, and discusses their implications for assisted reproductive techniques. We highlight evidence provided by genetically modified mouse models and in vitro studies which have refined our understanding of Pi3k/Akt and mTOR signalling in the oocyte and have discovered a role for Jak/Stat/Socs signalling in granulosa cells during primordial follicle activation. We also appraise a novel role for the metal ion zinc in the regulation of meiosis I and meiosis II progression through early meiosis inhibitor (Emi2) and Mos-Mapk signalling, and examine studies which expand our understanding of intracellular calcium signalling and extrinsic Plc¿ in stimulating oocyte activation. © The Author 2012. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved.

DOI10.1093/molehr/gas065
CitationsScopus - 10Web of Science - 10
2013O'Bryan MK, Clark BJ, McLaughlin EA, D'Sylva RJ, O'Donnell L, Wilce JA, et al., 'RBM5 Is a Male Germ Cell Splicing Factor and Is Required for Spermatid Differentiation and Male Fertility', PLOS GENETICS, 9 (2013) [C1]
DOI10.1371/journal.pgen.1003628Author URL
CitationsScopus - 2Web of Science - 2
2013Sominsky L, Sobinoff AP, Jobling MS, Pye V, McLaughlin EA, Hodgson DM, 'Immune regulation of ovarian development: programming by neonatal immune challenge.', Frontiers in Neuroscience, 7 100 (2013) [C1]
DOI10.3389/fnins.2013.00100Author URL
Co-authorsDeborah Hodgson
2013McIver SC, Loveland KL, Roman SD, Nixon B, Kitazawa R, McLaughlin EA, 'The chemokine CXCL12 and its receptor CXCR4 are implicated in human seminoma metastasis', ANDROLOGY, 1 517-529 (2013) [C1]
DOI10.1111/j.2047-2927.2013.00081.xAuthor URL
CitationsScopus - 8Web of Science - 9
Co-authorsBrett Nixon, Shaun Roman
2012Merriman-Jones JA, Jennings PC, McLaughlin EA, Jones KT, 'Effect of aging on superovulation efficiency, aneuploidy rates, and sister chromatid cohesion in mice aged up to 15 months', Biology of Reproduction, 86 1-6 (2012) [C1]
CitationsScopus - 22Web of Science - 21
Co-authorsKeith Jones
2012Sominsky Bar L, Meehan CL, Walker AK, Bobrovskaya L, McLaughlin EA, Hodgson DM, 'Neonatal immune challenge alters reproductive development in the female rat', Hormones and Behavior, 62 345-355 (2012) [C1]
CitationsScopus - 9Web of Science - 6
Co-authorsDeborah Hodgson
2012Sutherland JM, Keightley RA, Nixon B, Roman SD, Robker RL, Russell DL, McLaughlin EA, 'Suppressor of cytokine signaling 4 (SOCS4): Moderator of ovarian primordial follicle activation', Journal of Cellular Physiology, 227 1188-1198 (2012) [C1]
CitationsScopus - 8Web of Science - 7
Co-authorsShaun Roman, Brett Nixon
2012Sobinoff AP, Pye VJ, Nixon B, Roman SD, McLaughlin EA, 'Jumping the gun: Smoking constituent BaP causes premature primordial follicle activation and impairs oocyte fusibility through oxidative stress', Toxicology and Applied Pharmacology, 260 70-80 (2012) [C1]
CitationsScopus - 21Web of Science - 19
Co-authorsShaun Roman, Brett Nixon
2012Dun MD, Anderson AL, Bromfield EG, Asquith KL, Emmett BJ, McLaughlin EA, et al., 'Investigation of the expression and functional significance of the novel mouse sperm protein, a disintegrin and metalloprotease with thrombospondin type 1 motifs number 10 (ADAMTS10)', International Journal of Andrology, 35 572-589 (2012) [C1]
DOI10.1111/j.1365-2605.2011.01235.x
CitationsScopus - 6Web of Science - 5
Co-authorsJohn Aitken, Matt Dun, Brett Nixon
2012Sobinoff AP, Nixon B, Roman SD, McLaughlin EA, 'Staying alive: PI3K pathway promotes primordial follicle activation and survival in response to 3MC-induced ovotoxicity', Toxicological Sciences, 128 258-271 (2012) [C1]
CitationsScopus - 15Web of Science - 14
Co-authorsBrett Nixon, Shaun Roman
2012McIver SC, Roman SD, Nixon B, McLaughlin EA, 'miRNA and mammalian male germ cells', Human Reproduction Update, 18 44-59 (2012) [C1]
CitationsScopus - 39Web of Science - 37
Co-authorsShaun Roman, Brett Nixon
2012McIver SC, Stanger SJ, Santarelli DMF, Roman SD, Nixon B, McLaughlin EA, 'A unique combination of male germ cell mirnas coordinates gonocyte differentiation', PLoS One, 7 1-14 (2012) [C1]
CitationsScopus - 19Web of Science - 15
Co-authorsShaun Roman, Brett Nixon
2012Siddall NA, Kalcina M, Johanson TM, Monk AC, Casagranda F, Been RP, et al., 'Drosophila Rbp6 Is an orthologue of vertebrate Msi-1 and Msi-2, but does not function redundantly with dMsi to regulate germline stem cell behaviour', PloS One, 7 e49810 (2012) [C1]
CitationsScopus - 2Web of Science - 2
2011Gunter KM, McLaughlin EA, 'Translational control in germ cell development: A role for the RNA-binding proteins Musashi-1 and Musashi-2', IUBMB Life, 63 678-685 (2011) [C1]
CitationsScopus - 8Web of Science - 4
2011Monk AC, Siddall NA, Fraser BA, McLaughlin EA, Hime GR, 'Differential roles of HOW in male and female Drosophila germline differentiation', PLoS ONE, 6 e28508 (2011) [C1]
CitationsScopus - 2Web of Science - 2
2011Redgrove KA, Anderson AL, Dun MD, McLaughlin EA, O'Bryan MK, Aitken RJ, Nixon B, 'Involvement of multimeric protein complexes in mediating the capacitation-dependent binding of human spermatozoa to homologous zonae pellucidae', Developmental Biology, 356 460-474 (2011) [C1]
DOI10.1016/j.ydbio.2011.05.674
CitationsScopus - 20Web of Science - 22
Co-authorsJohn Aitken, Matt Dun, Brett Nixon
2011Nixon B, Mitchell LA, Anderson AL, McLaughlin EA, O'Bryan MK, Aitken RJ, 'Proteomic and functional analysis of human sperm detergent resistant membranes', Journal of Cellular Physiology, 226 2651-2665 (2011) [C1]
DOI10.1002/jcp.22615
CitationsScopus - 31Web of Science - 28
Co-authorsJohn Aitken, Brett Nixon
2011McLaughlin EA, Aitken RJ, 'Is there a role for immunocontraception?', Molecular and Cellular Endocrinology, 335 78-88 (2011) [C1]
DOI10.1016/j.mce.2010.04.004
CitationsScopus - 15Web of Science - 13
Co-authorsJohn Aitken
2011Walker AK, Hiles SA, Sominsky Bar L, McLaughlin EA, Hodgson DM, 'Neonatal lipopolysaccharide exposure impairs sexual development and reproductive success in the Wistar rat', Brain, Behavior, and Immunity, 25 674-684 (2011) [C1]
CitationsScopus - 17Web of Science - 15
Co-authorsDeborah Hodgson
2011McLaughlin EA, Hime GR, 'Spermatids do it differently! Paip2a-the essential regulator of spermiogenesis?', Asian Journal of Andrology, 13 122-124 (2011) [C2]
DOI10.1038/aja.2010.142
CitationsScopus - 3Web of Science - 2
2011Sobinoff AP, Mahony M, Nixon B, Roman SD, McLaughlin EA, 'Understanding the villain: DMBA-induced preantral ovotoxicity involves selective follicular destruction and primordial follicle activation through PI3K/Akt and mTOR signaling', Toxicological Sciences, 123 563-575 (2011) [C1]
CitationsScopus - 21Web of Science - 20
Co-authorsBrett Nixon, Shaun Roman
2010Monk AC, Siddall NA, Volk T, Fraser BA, Quinn LM, McLaughlin EA, Hime GR, 'HOW is required for stem cell maintenance in the drosophila testis and for the onset of transit-amplifying divisions', Cell Stem Cell, 6 348-360 (2010) [C1]
DOI10.1016/j.stem.2010.02.016
CitationsScopus - 16Web of Science - 16
2010Sobinoff AP, Pye VJ, Nixon B, Roman SD, McLaughlin EA, 'Adding insult to injury: Effects of xenobiotic-induced preantral ovotoxicity on ovarian development and oocyte fusibility', Toxicological Sciences, 118 653-666 (2010) [C1]
DOI10.1093/toxsci/kfq272
CitationsScopus - 17Web of Science - 16
Co-authorsShaun Roman, Brett Nixon
2009McLaughlin EA, McIver SC, 'Awakening the oocyte: Controlling primordial follicle development', Reproduction, 137 1-11 (2009) [C1]
DOI10.1530/rep-08-0118
CitationsScopus - 56Web of Science - 56
2009Nixon B, Bielanowicz AJ, McLaughlin EA, Tanphaichitr N, Ensslin MA, Aitken RJ, 'Composition and significance of detergent resistant membranes in mouse spermatozoa', Journal of Cellular Physiology, 218 122-134 (2009) [C1]
DOI10.1002/jcp.21575
CitationsScopus - 60Web of Science - 54
Co-authorsBrett Nixon, John Aitken
2009Yu DMT, Ajami K, Gall MG, Park J, Lee CS, Evans KA, et al., 'The in vivo expression of dipeptidyl peptidases 8 and 9', Journal of Histochemistry & Cytochemistry, 57 1025-1038 (2009) [C1]
DOI10.1369/jhc.2009.953760
CitationsScopus - 38Web of Science - 38
2008Koppers AJ, De Iuliis GN, Read JM, McLaughlin EA, Aitken RJ, 'Significance of mitochondrial reactive oxygen species in the generation of oxidative stress in spermatozoa', Journal of Clinical Endocrinology & Metabolism, 93 3199-3207 (2008) [C1]
DOI10.1210/jc.2007-2616
CitationsScopus - 143Web of Science - 146
Co-authorsJohn Aitken, Geoffry DeiuliIs
2007Fitzsimmons C, McLaughlin EA, Mahony MJ, Clulow J, 'Optimisation of handling, activation and assessment procedures for Bufo marinus spermatozoa', Reproduction, Fertility and Development, 19 594-601 (2007) [C1]
DOI10.1071/RD06124
CitationsScopus - 9Web of Science - 9
Co-authorsJohn Clulow
2007Aitken RJ, Wingate JK, De Iuliis GN, McLaughlin EA, 'Analysis of lipid peroxidation in human spermatozoa using BODIPY C11', Molecular Human Reproduction, 13 203-211 (2007) [C1]
DOI10.1093/molehr/gal119
CitationsScopus - 59Web of Science - 62
Co-authorsGeoffry DeiuliIs, John Aitken
2007Nixon B, Aitken RJ, McLaughlin EA, 'New insights into the molecular mechanisms of sperm-egg interaction', Cellular and Molecular Life Sciences, 64 1805-1823 (2007) [C1]
DOI10.1007/s00018-007-6552-x
Co-authorsJohn Aitken, Brett Nixon
2007Aitken RJ, McLaughlin EA, 'Molecular mechanisms of sperm capacitation: progesterone-induced secondary calcium oscillations reflect the attainment of a capacitated state', Society of Reproduction and Fertility Supplement, 63 273-293 (2007) [C1]
CitationsScopus - 25
Co-authorsJohn Aitken
2006De Iuliis GN, Wingate JK, Koppers AJ, McLaughlin EA, Aitken RJ, 'Definitive evidence for the nonmitochondrial production of superoxide anion by human spermatozoa', Journal of Clinical Endocrinology and Metabolism, 91 1968-1975 (2006) [C1]
DOI10.1210/jc.2005-2711
CitationsScopus - 61Web of Science - 48
Co-authorsJohn Aitken, Geoffry DeiuliIs
2006Aitken RJ, Wingate JK, De Iuliis GN, Koppers AJ, McLaughlin EA, 'Cis-unsaturated Fatty acids stimulate reactive oxygen species generation and lipid peroxidation in human spermatozoa', Journal of Clinical Endocrinology and Metabolism, 91 4154-4163 (2006) [C1]
DOI10.1210/jc.2006-1309
CitationsScopus - 75Web of Science - 72
Co-authorsJohn Aitken, Geoffry DeiuliIs
2006Holt JE, Roman SD, Aitken RJ, McLaughlin EA, 'Identification and characterization of a novel Mt-retrotransposon highly represented in the female mouse germline', Genomics, 87 490-499 (2006) [C1]
DOI10.1016/j.ygeno.2005.08.015
CitationsScopus - 3Web of Science - 3
Co-authorsJohn Aitken, Janet Holt, Shaun Roman
2006Curry BJ, Holt JE, McLaughlin EA, Aitken RJ, 'Characterization of structure and expression of the Dzip1 gene in the rat and mouse', Genomics, 87 275-285 (2006) [C1]
DOI10.1016/j.ygeno.2005.10.007
CitationsScopus - 2Web of Science - 2
Co-authorsJohn Aitken, Ben Curry, Janet Holt
2006Holt JE, Jackson A, Roman SD, Aitken RJ, Koopman PA, McLaughlin EA, 'CXCR4/SDF1 interaction inhibits the primordial to primary follicle transition in the neonatal mouse ovary', Developmental Biology, 293 449-460 (2006) [C1]
DOI10.1016/j.ydbio.2006.02.012
CitationsScopus - 47Web of Science - 44
Co-authorsJohn Aitken, Shaun Roman, Janet Holt
2006Hutt KJ, McLaughlin EA, Holland MK, 'Primordial follicle activation and follicular development in the juvenile rabbit ovary', Cell and Tissue Research, 326 809-822 (2006) [C1]
DOI10.1007/s00441-006-0223-3
CitationsScopus - 20Web of Science - 19
2006Hutt KJ, McLaughlin EA, Holland MK, 'Kit ligand and c-Kit have diverse roles during mammalian oogenesis and folliculogenesis', Molecular Human Reproduction, 12 61-69 (2006) [C1]
DOI10.1093/molehr/gal010
CitationsScopus - 78Web of Science - 74
2006Prabhu SM, Meistrich ML, McLaughlin EA, Roman SD, Warne S, Mendis S, et al., 'Expression of c-Kit receptor mRNA and protein in the developing, adult and irradiated rodent testis', Reproduction, 131 489-499 (2006) [C1]
DOI10.1530/rep.1.00968
CitationsScopus - 34Web of Science - 37
Co-authorsShaun Roman
2006Mackenzie SM, McLaughlin EA, Perkins HD, French N, Sutherland T, Jackson RJ, et al., 'Immunocontraceptive effects on female rabbits infected with recombinant myxoma virus expressing rabbit ZP2 or ZP3', Biology of Reproduction, 74 511-521 (2006) [C1]
DOI10.1095/biolreprod.105.046268
CitationsScopus - 22Web of Science - 19
2006Hutt KJ, McLaughlin EA, Holland MK, 'KIT/KIT ligand in mammalian oogenesis and folliculogenesis: Roles in rabbit and murine ovarian follicle activation and oocyte growth', Biology of Reproduction, 75 421-433 (2006) [C1]
DOI10.1095/biolreprod.106.051516
CitationsScopus - 51Web of Science - 46
2005Telfer EE, Gosden RG, Byskov AG, Spears N, Albertini D, Andersen CY, et al., 'On regenerating the ovary and generating controversy', Cell, 122 821-822 (2005) [C1]
DOI10.1016/j.cell.2005.09.004
CitationsScopus - 100Web of Science - 94
2004Blackmore DG, Baillie LR, Holt JE, Dierkx LM, Aitken RJ, McLaughlin EA, 'Biosynthesis of the Canine Zona Pellucida Requires the Integrated Participation of Both Oocytes and Granulosa Cells', Biology of Reproduction, 71 661-668 (2004) [C1]
DOI10.1095/biolreprod.104.028779
CitationsScopus - 25Web of Science - 24
Co-authorsJohn Aitken, Janet Holt
2004Baker MA, Krutskikh A, Curry BJ, McLaughlin EA, Aitken RJ, 'Identification of Cytochrome P450-Reductase as the Enzyme Responsible for NADPH-Dependent Lucigenin and Tetrazolium Salt Reduction in Rat Epididymal Sperm Preparations', Biology of Reproduction, 71 307-318 (2004) [C1]
DOI10.1095/biolreprod.104.027748
CitationsScopus - 35Web of Science - 34
Co-authorsJohn Aitken, Mark Baker, Ben Curry
2004Asquith KL, Baleato R, McLaughlin EA, Nixon B, Aitken RJ, 'Tyrosine phosphorylation activates surface chaperones facilitating sperm-zona recognition', Journal of Cell Science, 117 3645-3657 (2004) [C1]
DOI10.1242/jcs.01214
CitationsScopus - 104Web of Science - 94
Co-authorsBrett Nixon, John Aitken
2004Kerr PJ, Perkins HD, Inglis B, Stagg R, McLaughlin EA, Collins SV, Van Leeuwen BH, 'Expression of rabbit IL-4 by recombinant myxoma viruses enhances virulence and overcomes genetic resistance to myxomatosis', Virology, 324 117-128 (2004) [C1]
DOI10.1016/j.virol.2004.02.031
CitationsScopus - 22Web of Science - 21
2004Curry BJ, Su H, Law EG, McLaughlin EA, Nixon B, Aitken RJ, 'Identification of RARhoGAP, a novel putative RhoGAP gene expressed in male germ cells', Genomics, 84 406-418 (2004) [C1]
DOI10.1016/j.ygeno.2004.03.004
CitationsScopus - 9Web of Science - 10
Co-authorsBen Curry, John Aitken, Brett Nixon
2004Aitken RJ, Ryan AL, Baker MA, McLaughlin EA, 'Redox activity associated with the maturation and capacitation of mammalian spermatozoa', Free Radical Biology and Medicine, 36 994-1010 (2004) [C1]
DOI10.1016/j.freeradbiomed.2004.01.017
CitationsScopus - 73Web of Science - 64
Co-authorsMark Baker, John Aitken
2003McLaughlin EA, Holland MK, Aitken RJ, 'Contraceptive vaccines', Expert Opinion on Biological Therapy, 3 829-841 (2003) [C1]
DOI10.1517/14712598.3.5.829
CitationsScopus - 11Web of Science - 8
Co-authorsJohn Aitken
2002Hancock P, McLaughlin EA, 'British Andrology Society guidelines for the assessment of post vasectomy semen samples', Journal of Clinical Pathology, 55 812-816 (2002) [C1]
CitationsScopus - 48Web of Science - 34
2002McLaughlin EA, 'Cryopreservation, screening and storage of sperm - The challenges for the twenty-first century', Human Fertility, 5 (2002) [C1]

The advent of HIV and the serious nature of the sequelae resulted in a major reassessment of artificial insemination practices in the UK. The development of human semen cryopreservation had enormous impact on reproductive medicine and the availability of cryopreserved quarantined donor semen became a mainstay for the treatment of male infertility in the UK. The regulation and accreditation of assisted reproductive technologies and the introduction of peer-reviewed guidelines have largely standardized clinical and laboratory practice. The introduction of assisted fertilization techniques such as intracytoplasmic sperm injection, testicular sperm retrieval and improved oncology treatments have placed pressure on reproductive biologists and cryobiologists to design and use cryopreservation protocols for the optimum survival of sperm.

CitationsScopus - 5
2001Ford WCL, Williams KM, Harrison S, Rees JM, Ray BD, McLaughlin EA, Hull MGR, 'Value of the hamster oocyte test and computerised measurements of sperm motility in predicting if four or more viable embryos will be obtained in an IVF cycle', INTERNATIONAL JOURNAL OF ANDROLOGY, 24 109-119 (2001) [C1]
DOI10.1046/j.1365-2605.2001.00284.xAuthor URL
CitationsScopus - 7Web of Science - 5
2001McLaughlin EA, Frayne J, Bloomberg G, Hall L, 'Do fertilin beta and cyritestin play a major role in mammalian sperm-oolemma interactions? A critical re-evaluation of the use of peptide mimics in identifying specific oocyte recognition proteins', MOLECULAR HUMAN REPRODUCTION, 7 313-317 (2001)
DOI10.1093/molehr/7.4.313Author URL
CitationsWeb of Science - 18
2001McLaughlin E, 'The screeing of sperm donors - in search of the perfect male', ART & Science, (2001) [C3]
2000McLaughlin EA, 'Recruitment of only cytomegalovirus (CMV) negative semen donors', HUMAN REPRODUCTION, 15 2248-2249 (2000)
Author URL
1999Whittington K, Harrison SC, Williams KM, Day JL, Mclaughlin EA, Hull MGR, Ford WCL, 'Reactive oxygen species (ROS) production and the outcome of diagnostic tests of sperm function', INTERNATIONAL JOURNAL OF ANDROLOGY, 22 236-242 (1999)
DOI10.1046/j.1365-2605.1999.00174.xAuthor URL
CitationsWeb of Science - 32
1999McLaughlin EA, 'Ensuring the safe cryopreservation of tissues & cells', CRYO-LETTERS, 20 133-136 (1999)
Author URL
1998McLaughlin EA, Day J, Harrison S, Mitchell J, Prosser C, Hull M, 'Recruitment of gamete donors and payment of expenses', HUMAN REPRODUCTION, 13 1130-1132 (1998)
Author URL
CitationsWeb of Science - 7
1998Hull MGR, Williams JAC, Ray B, McLaughlin EA, Akande VA, Ford WCL, 'The contribution of subtle oocyte or sperm dysfunction affecting fertilization in endometriosis-associated or unexplained infertility: A controlled comparison with tubal infertility and use of donor spermatozoa', HUMAN REPRODUCTION, 13 1825-1830 (1998)
DOI10.1093/humrep/13.7.1825Author URL
CitationsWeb of Science - 60
1998Williams K, Frayne J, McLaughlin EA, Hall L, 'Expression of extracellular superoxide dismutase in the human male reproductive tract, detected using antisera raised against a recombinant protein', MOLECULAR HUMAN REPRODUCTION, 4 235-242 (1998)
DOI10.1093/molehr/4.3.235Author URL
CitationsWeb of Science - 21
1997Williams JAC, Ray B, McLaughlin EA, Hull MGR, 'The contribution of subtle oocyte or sperm dysfunction to endometriosis-associated and unexplained infertility', HUMAN REPRODUCTION, 12 P157-P157 (1997)
Author URL
1996Coulson C, McLaughlin EA, Harris S, Ford WCL, Hull MGR, 'Randomized controlled trial of cervical cap with intracervical reservoir versus standard intracervical injection to inseminate cryopreserved donor semen', HUMAN REPRODUCTION, 11 84-87 (1996)
Author URL
CitationsWeb of Science - 5
1996Liversedge NH, Jenkins JM, Keay SD, McLaughlin EA, AlSufyan H, Maile LA, et al., 'Antibiotic treatment based on seminal cultures from asymptomatic male partners in in-vitro fertilization is unnecessary and may be detrimental', HUMAN REPRODUCTION, 11 1227-1231 (1996)
Author URL
CitationsWeb of Science - 20
1996Ford WCL, Williams KM, McLaughlin EA, Harrison S, Ray B, Hull MGR, 'The indirect immunobead test for seminal antisperm antibodies and fertilization rates at in-vitro fertilization', HUMAN REPRODUCTION, 11 1418-1422 (1996)
Author URL
CitationsWeb of Science - 29
1995PLANT A, MCLAUGHLIN EA, FORD WCL, 'INTRACELLULAR CALCIUM MEASUREMENTS IN INDIVIDUAL HUMAN SPERM DEMONSTRATE THAT THE MAJORITY CAN RESPOND TO PROGESTERONE', FERTILITY AND STERILITY, 64 1213-1215 (1995)
Author URL
CitationsWeb of Science - 32
1995FOWLER PA, FAHY U, CULLER MD, KNIGHT PG, WARDLE PG, MCLAUGHLIN EA, et al., 'GONADOTROPIN SURGE-ATTENUATING FACTOR BIOACTIVITY IS PRESENT IN FOLLICULAR-FLUID FROM NATURALLY CYCLING WOMEN', HUMAN REPRODUCTION, 10 68-74 (1995)
Author URL
CitationsWeb of Science - 20
1994FOWLER PA, FRASER M, CUNNINGHAM P, KNIGHT PG, BYRNE B, MCLAUGHLIN EA, et al., 'HIGHER GONADOTROPIN SURGE-ATTENUATING FACTOR BIOACTIVITY IS FOUND IN SMALL FOLLICLES FROM SUPEROVULATED WOMEN', JOURNAL OF ENDOCRINOLOGY, 143 33-44 (1994)
DOI10.1677/joe.0.1430033Author URL
CitationsWeb of Science - 27
1994MCLAUGHLIN EA, FORD WCL, HULL MGR, 'ADENOSINE-TRIPHOSPHATE AND MOTILITY CHARACTERISTICS AF FRESH AND CRYOPRESERVED HUMAN SPERMATOZOA', INTERNATIONAL JOURNAL OF ANDROLOGY, 17 19-23 (1994)
DOI10.1111/j.1365-2605.1994.tb01203.xAuthor URL
CitationsWeb of Science - 4
1994FORD WCL, REES JM, McLAUGHLIN EA, LING L, HULL MGR, 'Pentoxifylline acts synergistically with A23187 to increase the penetration of zona-free hamster oocytes by cryopreserved human spermatozoa', International Journal of Andrology, 17 199-204 (1994)
DOI10.1111/j.1365-2605.1994.tb01243.x
1994CORRIGAN E, MCLAUGHLIN EA, COULSON N, FORD WCL, HULL MGR, 'THE EFFECT OF HALVING THE STANDARD-DOSE OF CRYOPRESERVED SEMEN FOR DONOR INSEMINATION - A CONTROLLED-STUDY OF CONCEPTION RATES', HUMAN REPRODUCTION, 9 330-333 (1994)
Author URL
CitationsWeb of Science - 7
1994MCLAUGHLIN EA, FORD WCL, 'EFFECTS OF CRYOPRESERVATION ON THE INTRACELLULAR CALCIUM-CONCENTRATION OF HUMAN SPERMATOZOA AND ITS RESPONSE TO PROGESTERONE', MOLECULAR REPRODUCTION AND DEVELOPMENT, 37 241-246 (1994)
DOI10.1002/mrd.1080370216Author URL
CitationsWeb of Science - 40
1993MCLAUGHLIN EA, FORD WCL, HULL MGR, 'EFFECTS OF CRYOPRESERVATION ON THE HUMAN SPERM ACROSOME AND ITS RESPONSE TO A23187', JOURNAL OF REPRODUCTION AND FERTILITY, 99 71-76 (1993)
Author URL
CitationsWeb of Science - 21
1992MCLAUGHLIN EA, FORD WCL, HULL MGR, 'MOTILITY CHARACTERISTICS AND MEMBRANE INTEGRITY OF CRYOPRESERVED HUMAN SPERMATOZOA', JOURNAL OF REPRODUCTION AND FERTILITY, 95 527-534 (1992)
Author URL
CitationsWeb of Science - 61
1992MCLAUGHLIN EA, FORD WCL, HULL MGR, 'THE CONTRIBUTION OF THE TOXICITY OF A GLYCEROL EGG-YOLK CITRATE CRYOPRESERVATIVE TO THE DECLINE IN HUMAN SPERM MOTILITY DURING CRYOPRESERVATION', JOURNAL OF REPRODUCTION AND FERTILITY, 95 749-754 (1992)
Author URL
CitationsWeb of Science - 32
1992FORD WCL, PONTING FA, MCLAUGHLIN EA, REES JM, HULL MGR, 'CONTROLLING THE SWIMMING SPEED OF HUMAN SPERM BY VARYING THE INCUBATION-TEMPERATURE AND ITS EFFECT ON CERVICAL-MUCUS PENETRATION', INTERNATIONAL JOURNAL OF ANDROLOGY, 15 127-134 (1992)
DOI10.1111/j.1365-2605.1992.tb01121.xAuthor URL
CitationsWeb of Science - 10
1992FORD WCL, MCLAUGHLIN EA, PRIOR SM, REES JM, WARDLE PG, HULL MGR, 'THE YIELD, MOTILITY AND PERFORMANCE IN THE HAMSTER EGG TEST OF HUMAN SPERMATOZOA PREPARED FROM CRYOPRESERVED SEMEN BY 4 DIFFERENT METHODS', HUMAN REPRODUCTION, 7 654-659 (1992)
Author URL
CitationsWeb of Science - 24
1991FORD WCL, REES JM, MCLAUGHLIN EA, GODDARD RJ, HULL MGR, 'THE EFFECT OF A23187 CONCENTRATION AND EXPOSURE TIME ON THE OUTCOME OF THE HAMSTER EGG PENETRATION TEST', INTERNATIONAL JOURNAL OF ANDROLOGY, 14 127-139 (1991)
DOI10.1111/j.1365-2605.1991.tb01074.xAuthor URL
CitationsWeb of Science - 9
1990McLaughlin EA, Ford WC, 'A comparison of the freezing of human semen in the uncirculated vapour above liquid nitrogen and in a commercial semi-programmable freezer.', Human Reproduction, 5 724-728 (1990)
1988HARRIS MA, REES JM, MCLAUGHLIN EA, FORD WCL, WARDLE PG, HULL MGR, WATHES DC, 'AN EVALUATION OF THE ROLE OF RELAXIN IN THE PENETRATION OF CERVICAL-MUCUS BY SPERMATOZOA', HUMAN REPRODUCTION, 3 856-860 (1988)
Author URL
CitationsWeb of Science - 10
1987WARDLE PG, MCLAUGHLIN E, SYKES JA, HULL MGR, 'INTRAUTERINE INSEMINATION', LANCET, 1 270-270 (1987)
Author URL
CitationsWeb of Science - 1
1987WALKER A, GREGSON S, MCLAUGHLIN E, 'ATTITUDES TOWARDS DONOR INSEMINATION - A POST-WARNOCK SURVEY', HUMAN REPRODUCTION, 2 745-750 (1987)
Author URL
CitationsWeb of Science - 16
1987RAY BD, MCDERMOTT A, WARDLE PG, CORRIGAN E, MITCHELL JD, MCLAUGHLIN EA, et al., 'INVITRO FERTILIZATION - FERTILIZATION FAILURE DUE TO TOXIC CATHETERS', JOURNAL OF IN VITRO FERTILIZATION AND EMBRYO TRANSFER, 4 58-61 (1987)
DOI10.1007/BF01555438Author URL
CitationsWeb of Science - 8
1986WARDLE PG, FOSTER PA, MITCHELL JD, MCLAUGHLIN EA, SYKES JAC, CORRIGAN E, et al., 'ENDOMETRIOSIS AND IVF - EFFECT OF PRIOR THERAPY', LANCET, 1 276-277 (1986)
Author URL
CitationsWeb of Science - 33
1986WARDLE PG, FOSTER PA, MITCHELL JD, MCLAUGHLIN EA, WILLIAMS JAC, CORRIGAN E, et al., 'NORETHISTERONE TREATMENT TO CONTROL TIMING OF THE IVF CYCLE', HUMAN REPRODUCTION, 1 455-457 (1986)
Author URL
CitationsWeb of Science - 20
1986WATHES DC, WARDLE PG, REES JM, MITCHELL JD, MCLAUGHLIN EA, HULL MGR, PORTER DG, 'IDENTIFICATION OF RELAXIN IMMUNOREACTIVITY IN HUMAN FOLLICULAR-FLUID', HUMAN REPRODUCTION, 1 515-517 (1986)
Author URL
CitationsWeb of Science - 9
1986WARDLE PG, MCLAUGHLIN EA, WILLIAMS JAC, MITCHELL JD, FOSTER PA, CORRIGAN E, et al., 'SEMINAL ANALYSIS AND CLINICAL SPERM FUNCTION-TESTS - DEFINITION OF NORMAL VALUES USING INVITRO FERTILIZATION (IVF)', BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 93 1195-1195 (1986)
Author URL
1985WARDLE PG, MITCHELL JD, MCLAUGHLIN EA, RAY BD, MCDERMOTT A, HULL MGR, 'ENDOMETRIOSIS AND OVULATORY DISORDER - REDUCED FERTILIZATION INVITRO COMPARED WITH TUBAL AND UNEXPLAINED INFERTILITY', LANCET, 2 236-239 (1985)
Author URL
CitationsWeb of Science - 146
1983MCLAUGHLIN EA, BROMWICH PD, MACKEN AM, WALKER AP, NEWTON J, 'USE OF HOME INSEMINATION IN PROGRAMS OF ARTIFICIAL-INSEMINATION WITH DONOR SEMEN', BRITISH MEDICAL JOURNAL, 287 1110-1110 (1983)
Author URL
CitationsWeb of Science - 1
Show 107 more journal articles

Review (2 outputs)

YearCitationAltmetricsLink
2007Nixon B, Aitken RJ, McLaughlin EA, 'New insights into the molecular mechanisms of sperm-egg interaction', CELLULAR AND MOLECULAR LIFE SCIENCES (2007) [D1]
DOI10.1007/s00018-007-6552-xAuthor URL
CitationsScopus - 61Web of Science - 59
Co-authorsBrett Nixon, John Aitken
1998Avery SM, McLaughlin EA, Dawson KJ, 'Safe cryopreservation of sperm and embryos.', Human Fertility (1998)

Conference (61 outputs)

YearCitationAltmetricsLink
2012Sobinoff AP, Beckett EL, Nixon B, Roman SD, Hansbro PM, McLaughlin EA, 'The impact of maternal cigarette smoke exposure on the male germline', Abstracts. The Annual Scientific Meeting of the Endocrine Society of Australia and the Society for Reproductive Biology 2012, Gold Coast, QLD (2012) [E3]
Co-authorsPhilip Hansbro, Shaun Roman, Brett Nixon
2012Sutherland JM, Fraser BA, Siddall NA, Hime GR, Davidson T-L, Koopman P, McLaughlin EA, 'Musashi-2: an essential regulator of DNA recombination and repair', Abstracts. The Annual Scientific Meeting of the Endocrine Society of Australia and the Society for Reproductive Biology 2012, Gold Coast, QLD (2012) [E3]
2012Sominsky Bar L, Moussavi M, Sobinoff AP, McLaughlin EA, Hodgson DM, 'Postnatal peripheral inflammatory challenge alters expression of ovarian signalling pathway - Implications for impaired reproductive development', Abstracts. The Annual Scientific Meeting of the Endocrine Society of Australia and the Society for Reproductive Biology 2012, Gold Coast, QLD (2012) [E3]
Co-authorsDeborah Hodgson
2012Loveland K, McLaughlin EA, Szczepny A, Jans D, 'Expression of hedgehog pathway regulators in the adult testis reveals dynamic control of signalling activity', Journal of Andrology, Tucson, AZ (2012) [E3]
2012Sominsky Bar L, Meehan CL, Walker AK, Bobrovskaya L, McLaughlin EA, Hodgson DM, 'Programming of reproductive development by neonatal immunological challenge: Evidence for transgenerational inheritance', Brain, Behavior, and Immunity, San Diego, CA (2012) [E3]
Co-authorsDeborah Hodgson
2010Siddall NA, Monk AC, Horvay K, Kalcina M, Johanson TM, Casagranda F, et al., 'Genetic regulation of stem cell differentiation by transcriptional and translational repressors', OzBio 2010: The Molecules of Life - from Discovery to Biotechnology. Abstracts, Melbourne, Vic (2010) [E3]
2010McLaughlin EA, Fraser BA, Pye VJ, Bigland MJ, Siddall NA, Hime GR, 'RNA binding protein Msi2: Cell cycle regulator in spermatogenesis', OzBio 2010: The Molecules of Life - from Discovery to Biotechnology. Abstracts, Melbourne, Vic (2010) [E3]
2010Fraser BA, Sobinoff AP, Pye VJ, Roman SD, Hime GR, Siddall NA, et al., 'Targets of RNA-binding protein Musashi-1 in mouse germ cell development', OzBio 2010: The Molecules of Life - from Discovery to Biotechnology. Poster Abstracts, Melbourne, Australia (2010) [E3]
Co-authorsShaun Roman
2010McIver SC, Roman SD, Nixon B, McLaughlin EA, 'MicroRNA signalling in early male germ cells', OzBio 2010: The Molecules of Life - from Discovery to Biotechnology. Poster Abstracts, Melbourne, Vic (2010) [E3]
Co-authorsShaun Roman, Brett Nixon
2010Pye VJ, Sobinoff AP, Nixon B, Roman SD, McLaughlin EA, 'Xenobiotics; influence on long term oocyte viability', OzBio 2010: The Molecules of Life - from Discovery to Biotechnology. Poster Abstracts, Melbourne, Vic (2010) [E3]
Co-authorsBrett Nixon, Shaun Roman
2010Redgrove KA, McLaughlin EA, O'Bryan MK, Aitken RJ, Nixon B, 'Identification and characterisation of surface protein complexes in human spermatozoa', OzBio 2010: The Molecules of Life - from Discovery to Biotechnology. Poster Abstracts, Melbourne, Vic (2010) [E3]
Co-authorsBrett Nixon, John Aitken
2010Sobinoff AP, Pye VJ, Nixon B, Roman SD, McLaughlin EA, 'Consistent mechanism of primordial follicle activation in neonatal mouse ovotoxicity', OzBio 2010: The Molecules of Life - from Discovery to Biotechnology. Poster Abstracts, Melbourne, Vic (2010) [E3]
Co-authorsBrett Nixon, Shaun Roman
2010Redgrove KA, Nixon B, McLaughlin EA, O'Bryan MK, Aitken RJ, 'Identification and Characterisation of Surface Protein Complexes in Human Spermatozoa', Reproduction, Fertility and Development, Sydney (2010) [E3]
Co-authorsJohn Aitken, Brett Nixon
2010Sobinoff AP, Pye VJ, Nixon B, Roman SD, McLaughlin EA, 'Short Term Xenobiotic Exposure Compromises Long Term Oocyte Viability', Reproduction, Fertility and Development, Sydney (2010) [E3]
Co-authorsShaun Roman, Brett Nixon
2010Sutherland JM, Keightley RA, Robker RL, Russell DL, McLaughlin EA, 'JAK/STAT Signalling in Folliculogenesis', Reproduction, Fertility and Development, Sydney (2010) [E3]
2010Watson LN, Robker RL, Dunning KR, McLaughlin EA, Russell DL, 'Conditional Targeted Deletions of STAT3 to Identify its Role in Oocytes and Granulosa Cells', Reproduction, Fertility and Development, Sydney (2010) [E3]
2010McIver SC, Roman SD, Nixon B, McLaughlin EA, 'Microrna and Early Male Germ Cells', Reproduction, Fertility and Development, Sydney (2010) [E3]
Co-authorsShaun Roman, Brett Nixon
2010Gunter KM, Fraser BA, Sobinoff AP, Pye VJ, Siddall NA, Hime GR, McLaughlin EA, 'Translational Control in Folliculogenesis and Oocyte Development: A Role for RNA-Binding Protein Musashi-1', Reproduction, Fertility and Development, Sydney (2010) [E3]
2010McLaughlin EA, Fraser BA, Pye VJ, Bigland MJ, Siddall NA, Hime GR, 'Musashi Family of RNA Binding Proteins: Cell Cycle Regulators in Spermatogenesis', Reproduction, Fertility and Development, Sydney (2010) [E3]
2010Hopkins LA, Pye VJ, Fraser BA, Holt JE, Jones KT, McLaughlin EA, 'The Role of Fizzy Related 1 in Male Meiosis', Reproduction, Fertility and Development, Sydney (2010) [E3]
Co-authorsKeith Jones, Janet Holt
2010Anderson AL, Mitchell LA, McLaughlin EA, O'Bryan MK, Aitken RJ, Nixon B, 'Proteomic and Functional Analysis of Human Sperm Detergent Resistant Membranes', Reproduction, Fertility and Development, Sydney (2010) [E3]
DOI10.1002/jcp.22615
Co-authorsJohn Aitken, Brett Nixon
2010Bernstein IR, McLaughlin EA, O'Bryan MK, 'SLX4, A Key Regulator of Meisosis and DNA Repair in the Male Germline', Reproduction, Fertility and Development, CSIRO Publishing (2010) [E3]
2010Tannock SJ, McLaughlin EA, Aitken RJ, Roman SD, 'SPIF - A Novel Testis-Specific Gene and its Interaction with PKA', Reproduction, Fertility and Development, Sydney (2010) [E3]
Co-authorsJohn Aitken, Shaun Roman
2009Roman SD, Stanger SJ, Borg Z, Low JL, McClymont SL, McLaughlin EA, 'Characterisation of spermatogonial stem cells', Regulatory Networks in Stem Cells: Program & Abstract Book, Singapore (2009) [E3]
Co-authorsShaun Roman
2008Fraser BA, Sobinoff A, Hime G, Siddall N, Roman SD, McLaughlin EA, 'The role of the RNA-binding protein, Musashi-1 in murine spermatogonial stem cell maintenance', Proceedings of 41st Annual Meeting of the Society for the Study of Reproduction., Kailua-Kona, Hawaii (2008) [E3]
Co-authorsShaun Roman
2008Nixon B, Bielanowicz AJ, McLaughlin EA, Tanphaichitr N, Ensslin M, Aitken RJ, 'The composition and significance of lipid rafts in mouse spermatozoa', Proceedings of 41st Annual Meeting of the Society for the Study of Reproduction., Kailua-Kona, Hawaii (2008) [E3]
Co-authorsJohn Aitken, Brett Nixon
2008McLaughlin EA, Gunter KM, Woollett K, Roman SD, 'Chemokines: Role in germ cell migration and survival', Proceedings of 41st Annual Meeting of the Society for the Study of Reproduction. "Reproductive Biology: Basic Discoveries that Affect Our Lives", Kailua-Kona, Hawaii (2008) [E3]
Co-authorsShaun Roman
2008Nixon B, Bielanowicz A, McLaughlin E, Tanphaichitr N, Ensslin M, Aitken R, 'The composition and significance of lipid rafts in mouse spermatozoa', BIOLOGY OF REPRODUCTION, Kona, HI (2008) [E3]
Author URL
Co-authorsBrett Nixon
2007Gunter KM, Fraser BA, Holt JE, Stanger SJ, Aitken RJ, Roman SD, McLaughlin EA, 'CXCR4/SDF1 interaction in the neonatal mouse testes', 7th Hunter Cellular Biology Meeting. Program, Hunter Valley, NSW (2007) [E3]
Co-authorsJohn Aitken, Janet Holt, Shaun Roman
2007Koppers AJ, McLaughlin EA, Aitken RJ, 'Mitochondria are a significant source of reactive oxygen species in human spermatozoa', Combined Conference Abstracts - ComBio 2007 Conference, Sydney (2007) [E3]
Co-authorsJohn Aitken
2007Hime GR, Siddall NA, Monk AC, Marriner NL, McLaughlin EA, 'Genetics of stem cells - How fruitflies can assist reproductive technology', Proceedings of the Thirty-Eighth Annual Conference Society for Reproductive Biology, Christchurch, New Zealand (2007) [E3]
2007McLaughlin EA, 'Under attack: Germ cell defences against environmental toxins?', Proceedings of the Thirty-Eighth Annual Conference Society for Reproductive Biology, Christchurch, New Zealand (2007) [E3]
2007Roman SD, Stanger SJ, Fraser BA, Borg Z, Low JL, McClymont SL, McLaughlin EA, 'Isolating and genotyping spermatogonial stem cells', Proceedings of the Thirty-Eighth Annual Conference Society for Reproductive Biology, Christchurch, New Zealand (2007) [E3]
Co-authorsShaun Roman
2006Fraser BA, Holt JE, Andrew J, Roman SD, Stanger SJ, Aitken RJ, et al., 'CXCR4/SDF1 Interactionin the Embryonic and Neonatal Mpise Testes', Abstracts, Brisbane Convention Centre, QLD, Australia (2006) [E3]
Co-authorsJohn Aitken, Janet Holt, Shaun Roman
2006McLaughlin EA, Dorey RA, Roman SD, Aitken RJ, 'Xenobiotis and Fertility: Expression Profiling of Defence Mechanisms Present in Murine Ovary', Abstract Book, Lorne, VIC, Australia (2006) [E3]
Co-authorsJohn Aitken, Shaun Roman
2006Schjenken JE, Gilliam E, Borg Z, Aitken RJ, McLaughlin EA, Roman SD, 'Cytocrome P450 2E2 Mediates Acrylamide Damage to the Male Germ Line', Abstract Book, Lorne, VIC, Australia (2006) [E3]
Co-authorsJohn Aitken, Shaun Roman
2006Aitken RJ, 'Impact of unsaturated fatty acids on human sperm function', Abstracts, Qwest Center Omaha, Omaha, Nebraska (2006) [E3]
Co-authorsJohn Aitken
2006Aitken RJ, McLaughlin EA, 'Molecular mechanism in spem capacitation: progesterone induced secondary calcium oscillations reflect the attainment of a capacitated state', Book of Abstracts, New Delhi (2006) [E3]
Co-authorsJohn Aitken
2006Paul JW, Aitken RJ, McLaughlin EA, 'Oolemmal Proteomics: Characterisation of Glycophosphatidylinositol Anchored Proteins Involved in Murine Fertilisation', Book of Abstracts, Lorne, Victoria, Australia (2006) [E3]
Co-authorsJohn Aitken
2006Holt JE, Andrew J, Roman SD, Stanger SJ, Aitken RJ, Peter K, McLaughlin EA, 'CXCR4/SDF-1 interaction in the embryonic and neonatal mouse tests', Book of Abstracts, Chicago, Illinois (2006) [E3]
Co-authorsShaun Roman, Janet Holt, John Aitken
2005Ellem GK, McLaughlin EA, 'Tales from the coalface: From tragedy to triumph in a blended learning approach to the teaching of 1st year biology', Proceedings of the Blended Learning in Science Teaching and Learning Symposium, Sydney, NSW (2005) [E1]
2005Holt JE, Aitken RJ, Roman SD, McLaughlin E, 'Use of RNA interference for the functional analysis of genes involved in ovarian development', MECHANISMS OF DEVELOPMENT (2005) [E3]
Author URL
Co-authorsJanet Holt, Shaun Roman, John Aitken
2005Hime G, Marriner N, McLaughlin E, Roman S, Loveland K, Siddall N, 'The RNA-binding protein musashi is required for stem cell maintenance in the Drosophila testis', MECHANISMS OF DEVELOPMENT (2005) [E3]
Author URL
Co-authorsShaun Roman
2005Siddall NA, Marriner NL, McLaughlin EA, Roman SD, Loveland KL, Hime GR, 'The RNA-binding protein Musashi is required for stem cell maintenance in the Drosophila testis', 2nd Great Barrier Reef Drosophila Conference, Cairns, Australia (2005) [E3]
2005McLaughlin EA, Borg Z, Roman SD, Ball P, Loveland KL, Siddall NA, Hime GR, 'Musashi 1 & 2: role in murine spermatogonial stem cell maintenance and spermatogenesis', ASMR Hormones Fertility & Cancer, Couran Cove, Queensland (2005) [E1]
2005Williams JE, Aitken RJ, McLaughlin EA, 'Maintenance of feline primordial follicles by in vitro culture', ComBio 2005 (ABSBMB, ASPP, ANZCDB), Adelaide, Australia (2005) [E3]
2005Holt JE, Aitken RJ, Roman SD, McLaughlin EA, 'Use of RNAi for the functional analysis of genes involved in ovarian development', European Society For Human Reproduction And Embryology, Paris, France. (2005) [E3]
2005Holt JE, Aitken RJ, Roman S, McLaughlin EA, 'Expression of the chemokine CXCl12 and its receptor CXCR4 in the activating mammalian ovarian follicle.', Fertility 2005 Conference, Conventry, UK (2005) [E3]
2004Holt JE, Aitken RJ, Roman SD, McLaughlin EA, 'Expression of the Chemokine CXCL12 and its receptor CXCR4 in the activating Mammalian Ovarian follicle', Reproduction, Fertility and Development, Sydney (2004) [E3]
Co-authorsJanet Holt, John Aitken, Shaun Roman
2004Paul JW, McLaughlin EA, Aitken RJ, 'Oolemmal Proteomics: Identification of the Oocyte Cell Surface Protein Complexes Involved in Sperm-egg Interaction', Reproduction, Fertility and Development, Sydney (2004) [E3]
Co-authorsJohn Aitken
2004Hutt KJ, McLaughlin EA, Holland MK, 'Kit Ligand promotes follicle activation in cultured neonatal mouse ovaries but not in cultured rabbit ovarian cortical explants', Biology of Reproduction 2004 Special Issue, Vancouver, Canada (2004) [E3]
2004Asquith KL, Nixon B, McLaughlin EA, Aitken RJ, 'Tyrosine phosphorylation of mouse sperm proteins in a prerequisite for Zona Pellucida binding: potential involvement of molecular chaperones', Biology of Reproduction 2004 Special Issue, Vancouver, Canada (2004) [E3]
Co-authorsBrett Nixon, John Aitken
2004Roman SD, McLaughlin EA, 'Peer pressure and performance: meaningful team work', Proceedings of Scholarly Inquiry into Science Teaching and Leaning, University of Sydney (2004) [E3]
Co-authorsShaun Roman
2003Holt JE, Aitken RJ, Roman SD, McLaughlin EA, 'Gene expression in the activating mammalian ovarian follicle', ComBio Combined Conference Abstracts, Melbourne (2003) [E3]
Co-authorsShaun Roman, John Aitken, Janet Holt
2003Blackmore DG, McLaughlin EA, Aitken RJ, 'Lectin expression patterns of feline and canine oogenesis', ComBio Combined Conference Abstracts, Melbourne (2003) [E3]
Co-authorsJohn Aitken
2003Asquith KL, McLaughlin EA, Nixon B, Aitken RJ, 'Localisation of Tyrosine Phosphorylated Proteins on Mouse Spermatozoa during Zona Pellucida Interaction and Characterisation of Sperm Surface Phosphoproteins', Society for Reproductive Biology Proceedings of the Thirty-fourth Annual Conference, Melbourne (2003) [E3]
Co-authorsBrett Nixon, John Aitken
2003Hutt KJ, McLaughlin EA, Holland MK, 'The effect of kit ligand on follicle growth initiation in cultured rabbit and mouse ovaries', Society for Reproductive Biology Proceedings of the Thirty-fourth Annual Conference, Melbourne (2003) [E3]
2002McLaughlin EA, Robinson A, Inglis B, Swan J, Holland M, Kerr P, 'Immunocontraceptive effect of recombinant porcine Zona Pellucida C protein in rabbits', Proceedings of the Thirty-third Annual Conference of the Society for Reproductive Biology, Adelaide, SA (2002) [E3]
1997McLaughlin EA, Frayne J, Barker HL, Jury JA, Jones R, Ford WCL, Hall L, 'Cloning and sequence analysis of rat fertilin alpha and beta - Developmental expression, processing and immunolocalization', MOLECULAR HUMAN REPRODUCTION, YORK, ENGLAND (1997)
DOI10.1093/molehr/3.9.801Author URL
CitationsWeb of Science - 30
1997Hull MGR, Cahill DJ, Harlow CR, McLaughlin EA, Maile LA, Mears J, et al., 'Oocyte quality in endometriosis', HUMAN OOCYTES: FROM PHYSIOLOGY TO IVF, BOLOGNA, ITALY (1997)
Author URL
1995HOLMES CH, SIMPSON KL, HOULIHAN JM, MCLAUGHLIN EA, FORD WCL, 'Targeted abrogation of resistance to complement in the female reproductive tract: Applications locally in cancer therapy and immunocontraception', IMMUNOCONTRACEPTION, UPPSALA, SWEDEN (1995)
Author URL
Show 58 more conferences
Edit

Grants and Funding

Summary

Number of grants78
Total funding$29,420,012

Click on a grant title below to expand the full details for that specific grant.


20146 grants / $1,086,005

Chlamydia infection in males $630,558

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Eileen McLaughlin, Professor Kenneth Beagley
SchemeProject Grant
RoleLead
Funding Start2014
Funding Finish2014
GNoG1300117
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

miRNA regulation of sperm maturation $383,447

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamAssociate Professor Brett Nixon, Professor Eileen McLaughlin, Doctor Janet Holt
SchemeProject Grant
RoleInvestigator
Funding Start2014
Funding Finish2014
GNoG1300125
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

The Role of the GTPase Dynamin in the Female Germline$30,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamMs Kate Redgrove, Doctor Janet Holt, Professor Eileen McLaughlin, Associate Professor Brett Nixon
SchemeBridging Grant
RoleInvestigator
Funding Start2014
Funding Finish2014
GNoG1301333
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

The role of dynamin is spermatogenesis and sperm-oocyte interactions$20,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamAssociate Professor Brett Nixon, Professor Eileen McLaughlin, Professor Adam McCluskey
SchemeNear Miss Grant
RoleInvestigator
Funding Start2014
Funding Finish2014
GNoG1301400
Type Of FundingInternal
CategoryINTE
UONY

Understanding the Effects of Persistent Chlamydia Infection in the Male Germline$20,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamMs Kate Redgrove, Professor Eileen McLaughlin
SchemeProject Grant
RoleInvestigator
Funding Start2014
Funding Finish2014
GNoG1401440
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

Faculty PVC Conference Assistance Grant 2014$2,000

Funding body: University of Newcastle - Faculty of Science & IT

Funding bodyUniversity of Newcastle - Faculty of Science & IT
Project TeamProfessor Eileen McLaughlin
SchemePVC Conference Assistance Grant
RoleLead
Funding Start2014
Funding Finish2014
GNoG1401229
Type Of FundingInternal
CategoryINTE
UONY

20135 grants / $362,182

Novel function of heat shock protein 2A in the regulation of human sperm-egg interactions$292,182

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamAssociate Professor Brett Nixon, Laureate Professor John Aitken, Professor Eileen McLaughlin
SchemeProject Grant
RoleInvestigator
Funding Start2013
Funding Finish2013
GNoG1200193
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Chlamydia - Vaccine development to prevent adverse reproductive outcomes in males.$15,000

Funding body: University of Newcastle - Faculty of Science & IT

Funding bodyUniversity of Newcastle - Faculty of Science & IT
Project TeamProfessor Eileen McLaughlin
SchemeStrategic Small Grant
RoleLead
Funding Start2013
Funding Finish2013
GNoG1401066
Type Of FundingInternal
CategoryINTE
UONY

Dynamin - role in sperm oocyte interaction$10,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Eileen McLaughlin, Associate Professor Brett Nixon, Professor Adam McCluskey
SchemeNear Miss Grant
RoleLead
Funding Start2013
Funding Finish2013
GNoG1300483
Type Of FundingInternal
CategoryINTE
UONY

Dynamin - role in sperm oocyte interaction$10,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamProfessor Eileen McLaughlin, Associate Professor Brett Nixon, Professor Adam McCluskey
SchemeNear Miss
RoleLead
Funding Start2013
Funding Finish2013
GNoG1300700
Type Of FundingExternal
CategoryEXTE
UONY

20126 grants / $480,100

Role of Musashi in the regulation of cell cycle proteins$280,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamProfessor Eileen McLaughlin, Dr Gary Hime, Professor Margaret Fuller
SchemeDiscovery Projects
RoleLead
Funding Start2012
Funding Finish2012
GNoG1100068
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Hedgehog Signalling in Spermatogenesis$150,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamDr Kate Loveland, Professor Eileen McLaughlin
SchemeProject Grant
RoleLead
Funding Start2012
Funding Finish2012
GNoG1101100
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

The effects of cigarette smoke on the reproductive health of offspring using our unique mouse model.$15,100

Funding body: University of Newcastle - Faculty of Science & IT

Funding bodyUniversity of Newcastle - Faculty of Science & IT
Project TeamProfessor Eileen McLaughlin
SchemeStrategic Small Grant
RoleLead
Funding Start2012
Funding Finish2012
GNoG1401103
Type Of FundingInternal
CategoryINTE
UONY

BMG SPECTROstar Nano$15,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamLaureate Professor John Aitken, Professor Eileen McLaughlin, Ms Belinda Nixon, Doctor Shaun Roman, Doctor Mark Baker, Doctor Geoffry De Iuliis, Doctor Lisa Mitchell, Doctor Matthew Jobling
SchemeEquipment Grant
RoleInvestigator
Funding Start2012
Funding Finish2012
GNoG1100971
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

Ultrasonic Homogenizer System and -80 ºC Freezers for chemical and biological sample storage$10,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Adam McCluskey, Professor Eileen McLaughlin, Professor Peter Lewis, Ms Belinda Nixon, Doctor Shaun Roman, Doctor Jennette Sakoff, Doctor Ian Grainge
SchemeEquipment Grant
RoleInvestigator
Funding Start2012
Funding Finish2012
GNoG1100986
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

The role of miRNAs in the regulation of sperm maturation$10,000

Funding body: University of Newcastle - Faculty of Science & IT

Funding bodyUniversity of Newcastle - Faculty of Science & IT
Project TeamAssociate Professor Brett Nixon, Professor Eileen McLaughlin, Doctor Natalie Beveridge
SchemeStrategic Initiative Research Fund (SIRF)
RoleInvestigator
Funding Start2012
Funding Finish2012
GNoG1401028
Type Of FundingInternal
CategoryINTE
UONY

20117 grants / $1,849,961

Gamete-specific knockout of Fizzy-Related to examine its meiotic role in oocytes and sperm$600,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamProfessor Eileen McLaughlin, Conjoint Professor Keith Jones, Professor Sergio Moreno
SchemeDiscovery Projects
RoleLead
Funding Start2011
Funding Finish2011
GNoG1000020
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Establishment of a comprehensive regional biophysical analysis facility $500,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamProfessor Peter Lewis, Professor Nicholas Dixon, Professor Eileen McLaughlin, Professor Adam McCluskey, Associate Professor Aaron Oakley, Laureate Professor Paul Foster, Laureate Professor John Aitken, Associate Professor Jennifer Beck, Dr Michael Kelso, Professor Graham Nicholson, Associate Professor Elizabeth Harry, Professor Ian Charles, Associate Professor Steven Djordjevic
SchemeLinkage Infrastructure Equipment & Facilities (LIEF)
RoleInvestigator
Funding Start2011
Funding Finish2011
GNoG1000630
Type Of FundingScheme excluded from IGS
CategoryEXCL
UONY

Chemical Biology$444,961

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Adam McCluskey, Doctor Warwick Belcher, Doctor Ian Grainge, Professor Christopher Grof, Professor Peter Lewis, Professor Eileen McLaughlin, Doctor Shaun Roman, Conjoint Professor Ray Rose, Doctor Jennette Sakoff, Doctor Nikki Verrills
SchemePriority Research Centre
RoleInvestigator
Funding Start2011
Funding Finish2011
GNoG1100052
Type Of FundingInternal
CategoryINTE
UONY

Establishment of a comprehensive regional biophysical analysis facility $230,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamProfessor Peter Lewis, Professor Nicholas Dixon, Professor Eileen McLaughlin, Professor Adam McCluskey, Associate Professor Aaron Oakley, Laureate Professor Paul Foster, Laureate Professor John Aitken, Associate Professor Jennifer Beck, Dr Michael Kelso, Professor Graham Nicholson, Associate Professor Elizabeth Harry, Professor Ian Charles, Associate Professor Steven Djordjevic
SchemeLinkage Infrastructure Equipment & Facilities (LIEF) Partner funding
RoleInvestigator
Funding Start2011
Funding Finish2011
GNoG1100484
Type Of FundingScheme excluded from IGS
CategoryEXCL
UONY

Towards a Chlamydia vaccine for males: The key role of mucosal IgA$35,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Kenneth Beagley, Professor Eileen McLaughlin
SchemeProject Grant
RoleLead
Funding Start2011
Funding Finish2011
GNoG0190618
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

SLX4 - a key regulator of male germ cell development and DNA repair$25,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamProfessor Eileen McLaughlin, Associate Professor Brett Nixon
SchemeProject Grant
RoleLead
Funding Start2011
Funding Finish2011
GNoG1001000
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Eppendorf mastercycler pro with thermomixer comfort and 5430R centrifuge$15,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Eileen McLaughlin, Professor Peter Lewis, Professor Adam McCluskey, Conjoint Professor Keith Jones, Associate Professor Brett Nixon, Doctor Shaun Roman, Doctor Jennette Sakoff, Doctor Ian Grainge, Doctor Janet Holt, Doctor Xiao Yang
SchemeEquipment Grant
RoleLead
Funding Start2011
Funding Finish2011
GNoG1100028
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

20109 grants / $3,240,904

Development of a humane non-surgical sterilization method for domestic animals$1,006,825

Funding body: Found Animals Foundation Inc

Funding bodyFound Animals Foundation Inc
Project TeamLaureate Professor John Aitken, Professor Eileen McLaughlin, Professor Adam McCluskey
SchemeMichelson Grants in Reproductive Biology
RoleInvestigator
Funding Start2010
Funding Finish2010
GNoG0900113
Type Of FundingInternational - Competitive
Category3IFA
UONY

Sex Ratio and Sterility for Commercial animal production - round 5 Cluster$700,000

Funding body: CSIRO - Commonwealth Scientific and Industrial Research Organisation

Funding bodyCSIRO - Commonwealth Scientific and Industrial Research Organisation
Project TeamLaureate Professor John Aitken, Professor Eileen McLaughlin, Doctor Shaun Roman
SchemeNational Research Flagship Cluster
RoleInvestigator
Funding Start2010
Funding Finish2010
GNoG1000045
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

An Integrated LC-MS-NMR facility for Applications in Proteomics and Organic Chemistry$500,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamProfessor Adam McCluskey, Laureate Professor John Aitken, Professor Paul Dastoor, Professor Phillip Robinson, Professor Eileen McLaughlin, Emeritus Professor Geoffrey Lawrance, Professor Marcel Maeder, Professor Hugh Dunstan, Doctor Shaun Roman, Professor Rob Atkin, Doctor Clovia Holdsworth, Doctor Mark Baker, Doctor Nikki Verrills, Professor Gottfried Otting, Associate Professor Brett Nixon, Doctor Xiaojing Zhou, Ms Megan Chircop, Doctor Warwick Belcher
SchemeLinkage Infrastructure Equipment & Facilities (LIEF)
RoleInvestigator
Funding Start2010
Funding Finish2010
GNoG0190402
Type Of FundingScheme excluded from IGS
CategoryEXCL
UONY

An Integrated LC-MS-NMR facility for Applications in Proteomics and Organic Chemistry$280,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Adam McCluskey, Laureate Professor John Aitken, Professor Paul Dastoor, Professor Phillip Robinson, Professor Eileen McLaughlin, Emeritus Professor Geoffrey Lawrance, Professor Marcel Maeder, Professor Hugh Dunstan, Doctor Shaun Roman, Professor Rob Atkin, Doctor Clovia Holdsworth, Doctor Mark Baker, Doctor Nikki Verrills, Professor Gottfried Otting, Associate Professor Brett Nixon, Doctor Xiaojing Zhou, Ms Megan Chircop, Doctor Warwick Belcher
SchemeEquipment Grant
RoleInvestigator
Funding Start2010
Funding Finish2010
GNoG1000873
Type Of FundingInternal
CategoryINTE
UONY

Feasibility of Humane Camel Management$130,000

Funding body: CRC for Invasive Animals

Funding bodyCRC for Invasive Animals
Project TeamLaureate Professor John Aitken, Professor Eileen McLaughlin
SchemeResearch Grant
RoleInvestigator
Funding Start2010
Funding Finish2010
GNoG1100665
Type Of FundingCRC - Cooperative Research Centre
Category4CRC
UONY

Waters, Ultra high performance liquid chromatography system (nano-Aquity) $30,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamDoctor Mark Baker, Laureate Professor John Aitken, Professor Adam McCluskey, Associate Professor Brett Nixon, Emeritus Professor John Rostas, Professor Eileen McLaughlin
SchemeEquipment Grant
RoleInvestigator
Funding Start2010
Funding Finish2010
GNoG1000051
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

Electron Multiplier Charge-Coupled Device Camera. Hamamatsu EM-CCD Camera C9100-13$29,079

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamConjoint Professor Keith Jones, Professor Eileen McLaughlin, Professor Dirk Van Helden, Doctor Rick Thorne
SchemeEquipment Grant
RoleInvestigator
Funding Start2010
Funding Finish2010
GNoG1000052
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

20098 grants / $2,307,489

The role of the Anaphase-Promoting Complex activator Cdh1 in mammalian oocytes and aneuploidy$506,250

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamConjoint Professor Keith Jones, Professor Eileen McLaughlin
SchemeProject Grant
RoleInvestigator
Funding Start2009
Funding Finish2009
GNoG0188850
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Characterization of the molecular basis of human sperm-oocyte interaction$474,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamAssociate Professor Brett Nixon, Professor Eileen McLaughlin, Dr M O'Bryan
SchemeProject Grant
RoleInvestigator
Funding Start2009
Funding Finish2009
GNoG0188867
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

RNA binding proteins Musashi: role in foliculogenesis and oocyte development$402,750

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Eileen McLaughlin, Dr Gary Hime
SchemeProject Grant
RoleLead
Funding Start2009
Funding Finish2009
GNoG0188862
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Confocal Laser Scanning Microscopy for Live Cell Imaging$275,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamConjoint Professor Keith Jones, Professor Eileen McLaughlin, Laureate Professor John Aitken, Conjoint Professor Ray Rose, Emeritus Professor John Patrick, Conjoint Professor Christina Offler, Associate Professor David McCurdy, Emeritus Professor Leonie Ashman, Professor Gordon Burns, Professor Dirk Van Helden, Doctor Nikki Verrills, Associate Professor Brett Nixon, Doctor Shaun Roman, Associate Professor Yong-Ling Ruan, Doctor Rick Thorne, Professor Mike Calford
SchemeLinkage Infrastructure Equipment & Facilities (LIEF)
RoleInvestigator
Funding Start2009
Funding Finish2009
GNoG0189038
Type Of FundingScheme excluded from IGS
CategoryEXCL
UONY

Aging eggs: understanding the molecular mechanisms of declining female fertility$79,489

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamConjoint Professor Keith Jones, Professor Eileen McLaughlin
SchemeProject Grant
RoleInvestigator
Funding Start2009
Funding Finish2009
GNoG0189795
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

LAS-4000 Chemiluminescence imaging system$25,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Eileen McLaughlin, Laureate Professor John Aitken, Professor Peter Lewis, Associate Professor Brett Nixon, Doctor Shaun Roman
SchemeEquipment Grant
RoleLead
Funding Start2009
Funding Finish2009
GNoG0189852
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

200810 grants / $7,465,033

Centre for Biotechnology and Development$6,420,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamLaureate Professor John Aitken, Dr Gary Hime, Professor M Holland, Professor D Jans, Professor P Koopman, Dr Kate Loveland, Professor Eileen McLaughlin, Dr M O'Bryan, Doctor Shaun Roman, Assoc. Prof A Sinclair
SchemeARC Centres of Excellence
RoleInvestigator
Funding Start2008
Funding Finish2008
GNoG0188624
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Xenobiotics - ocidative stress in the mammalian ovary$362,625

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Eileen McLaughlin, Associate Professor Brett Nixon, Doctor Shaun Roman
SchemeProject Grant
RoleLead
Funding Start2008
Funding Finish2008
GNoG0187620
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Centre for Biotechnology and Development$297,273

Funding body: NSW Department of State and Regional Development

Funding bodyNSW Department of State and Regional Development
Project TeamLaureate Professor John Aitken, Dr Gary Hime, Professor M Holland, Professor D Jans, Professor P Koopman, Dr Kate Loveland, Professor Eileen McLaughlin, Dr M O'Bryan, Doctor Shaun Roman, Assoc. Prof A Sinclair
SchemeCentres of Excellence (Partner)
RoleInvestigator
Funding Start2008
Funding Finish2008
GNoG0189183
Type Of FundingOther Public Sector - State
Category2OPS
UONY

Cellular signals controlling oocyte activation$270,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamProfessor Eileen McLaughlin, Dr Darryl Russell, Dr Rebecca Robker
SchemeDiscovery Projects
RoleLead
Funding Start2008
Funding Finish2008
GNoG0187536
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

CEF Admin Relief McLaughlin$50,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Hugh Dunstan, Professor Eileen McLaughlin
SchemeCareer Enhancement Fellowship for Academic Women
RoleInvestigator
Funding Start2008
Funding Finish2008
GNoG0189257
Type Of FundingInternal
CategoryINTE
UONY

Understanding the aetiology of human male infertility: Elucidation of the mechanisms underpinning sperm-egg interaction$21,650

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamAssociate Professor Brett Nixon, Professor Eileen McLaughlin
SchemeProject Grant
RoleInvestigator
Funding Start2008
Funding Finish2008
GNoG0188465
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Characterization of the molecular basis of mouse sperm-oocyte interaction$18,285

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamAssociate Professor Brett Nixon, Professor Eileen McLaughlin
SchemeNear Miss Grant
RoleInvestigator
Funding Start2008
Funding Finish2008
GNoG0188405
Type Of FundingInternal
CategoryINTE
UONY

Programmed mammalian oocyte activation: the production line model of primordial follicle development$14,700

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Eileen McLaughlin, Conjoint Professor Keith Jones
SchemePilot Grant
RoleLead
Funding Start2008
Funding Finish2008
GNoG0189084
Type Of FundingInternal
CategoryINTE
UONY

Personal career development within the University of Newcastle in 2008$8,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Eileen McLaughlin
SchemeCareer Enhancement Fellowship for Academic Women
RoleLead
Funding Start2008
Funding Finish2008
GNoG0188507
Type Of FundingInternal
CategoryINTE
UONY

41st Annual Meeting of the Society for the Study of Reproduction $2,500

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Eileen McLaughlin
SchemeTravel Grant
RoleLead
Funding Start2008
Funding Finish2008
GNoG0188937
Type Of FundingInternal
CategoryINTE
UONY

20079 grants / $669,867

FACSAria - Fluorescence activated cell sorter$300,000

Funding body: Cancer Institute NSW

Funding bodyCancer Institute NSW
Project TeamDoctor Nikki Verrills, Emeritus Professor Leonie Ashman, Laureate Professor John Aitken, Professor Eileen McLaughlin, Professor Alistair Sim, Doctor Rick Thorne, Doctor Jennette Sakoff
SchemeResearch Infrastructure Grants
RoleInvestigator
Funding Start2007
Funding Finish2007
GNoG0187666
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Biotechnology applications in the veterinary pharmacuetical industry: Pharmacological manipulation of ovarian function in domestic animals$134,998

Funding body: Pestat Pty Ltd

Funding bodyPestat Pty Ltd
Project TeamProfessor Eileen McLaughlin, Laureate Professor John Aitken
SchemeLinkage Projects Partner funding
RoleLead
Funding Start2007
Funding Finish2007
GNoG0188204
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Centre for Biotechnology and Development.$96,220

Funding body: NSW Department of State and Regional Development

Funding bodyNSW Department of State and Regional Development
Project TeamLaureate Professor John Aitken, Dr Kate Loveland, Professor P Koopman, Assoc. Prof A Sinclair, Professor D De Krester, Dr M O'Bryan, Dr Gary Hime, Professor D Jans, Doctor Shaun Roman, Professor Eileen McLaughlin, Professor C Goodnow, Professor M Holland
SchemeCentres of Excellence (Partner)
RoleInvestigator
Funding Start2007
Funding Finish2007
GNoG0187937
Type Of FundingOther Public Sector - State
Category2OPS
UONY

HMRI Contribution toward FACSAria - Fluorescence activated cell sorter$52,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Nikki Verrills, Emeritus Professor Leonie Ashman, Laureate Professor John Aitken, Professor Eileen McLaughlin, Professor Alistair Sim, Doctor Rick Thorne, Doctor Jennette Sakoff
SchemeEquipment Grant
RoleInvestigator
Funding Start2007
Funding Finish2007
GNoG0188207
Type Of FundingOther Public Sector - State
Category2OPS
UONY

High speed/sensitivity CCD camera$30,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Dirk Van Helden, Professor Eileen McLaughlin, Professor Gordon Burns, Doctor Rick Thorne, Dr Marcus Howlett, Doctor Mohammad Imtiaz, Professor Alan Brichta, Professor Robert Callister, Doctor Brett Graham, Associate Professor Derek Laver, Associate Professor Liz Milward, Doctor John Holdsworth
SchemeEquipment Grant
RoleInvestigator
Funding Start2007
Funding Finish2007
GNoG0188196
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

Cytokines and Folliculogenesis$20,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Eileen McLaughlin
SchemeNear Miss Grant
RoleLead
Funding Start2007
Funding Finish2007
GNoG0187187
Type Of FundingInternal
CategoryINTE
UONY

Chemokines and spermatogenesis: roles of SDF-1 and CXCR-4 in the establishment of spermatogenesis$20,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Eileen McLaughlin, Doctor Shaun Roman, Associate Professor Brett Nixon
SchemeNear Miss Grant
RoleLead
Funding Start2007
Funding Finish2007
GNoG0187197
Type Of FundingInternal
CategoryINTE
UONY

Musashi 1 and 2 - role of RNA binding proteins in oocyte maturation$14,550

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Eileen McLaughlin
SchemePilot Grant
RoleLead
Funding Start2007
Funding Finish2007
GNoG0186712
Type Of FundingInternal
CategoryINTE
UONY

2007 SRB Annual Scientific Conference to be held in cnjunction with the ESA, Christchurch Convention Centre, New Zealand, 2/9/2007 - 5/9/2007$2,099

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Eileen McLaughlin
SchemeTravel Grant
RoleLead
Funding Start2007
Funding Finish2007
GNoG0188058
Type Of FundingInternal
CategoryINTE
UONY

20064 grants / $573,055

PRC - Priority Research Centre for Reproductive Science$544,282

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamLaureate Professor John Aitken, Professor Roger Smith, Professor Eileen McLaughlin, Associate Professor Brett Nixon, Doctor Shaun Roman, Conjoint Associate Professor Vicki Clifton, Conjoint Professor Warwick Giles, Professor Jon Hirst, Conjoint Associate Professor Rick Nicholson, Professor Ian Symonds
SchemePriority Research Centre
RoleInvestigator
Funding Start2006
Funding Finish2006
GNoG0186945
Type Of FundingInternal
CategoryINTE
UONY

Environmental impacts on female fertility and the menopause$17,273

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamProfessor Eileen McLaughlin, Laureate Professor John Aitken, Doctor Shaun Roman
SchemeResearch Grant
RoleLead
Funding Start2006
Funding Finish2006
GNoG0186620
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Cytokine signalling pathway and ovarian folliculogenesis$10,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Eileen McLaughlin, Dr Darryl Russell
SchemeNear Miss Grant
RoleLead
Funding Start2006
Funding Finish2006
GNoG0186066
Type Of FundingInternal
CategoryINTE
UONY

American Society of Andrology 31st Annual Conference, April 8 -11, 2006$1,500

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Eileen McLaughlin
SchemeTravel Grant
RoleLead
Funding Start2006
Funding Finish2006
GNoG0186466
Type Of FundingInternal
CategoryINTE
UONY

20053 grants / $224,726

SOCS-4 - modulation of cytokine and growth factor signalling in the mammalian ovary$10,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Eileen McLaughlin, Conjoint Associate Professor Renate Griffith
SchemeProject Grant
RoleLead
Funding Start2005
Funding Finish2005
GNoG0184635
Type Of FundingInternal
CategoryINTE
UONY

Oolemmal receptors - the role of the tetraspanin CD151 in sperm-egg fusion$7,537

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Eileen McLaughlin, Emeritus Professor Leonie Ashman
SchemeProject Grant
RoleLead
Funding Start2005
Funding Finish2005
GNoG0184625
Type Of FundingInternal
CategoryINTE
UONY

20046 grants / $1,655,790

Multifunctional confocal laser scanning microscope with time resolved and two photon imaging and fluorescence correlation capabilities $579,230

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project Team
SchemeUnknown
RoleLead
Funding Start2004
Funding Finish2004
GNo
Type Of FundingNot Known
CategoryUNKN
UONY

Biotechnology applications in the veterinary pharmaceutical industry: Pharmacological manipulation of ovarian function in domestic animals$465,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamProfessor Eileen McLaughlin, Laureate Professor John Aitken, Dr J O'Brien
SchemeLinkage Projects
RoleLead
Funding Start2004
Funding Finish2004
GNoG0183627
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Biotechnology applications in the veterinary pharmacuetical industry: Pharmacological manipulation of ovarian function in domestic animals$298,368

Funding body: Jurox

Funding bodyJurox
Project TeamProfessor Eileen McLaughlin, Laureate Professor John Aitken, Dr J O'Brien
SchemeLinkage Projects Partner funding
RoleLead
Funding Start2004
Funding Finish2004
GNoG0183816
Type Of FundingNot Known
CategoryUNKN
UONY

High-Speed Confocal Microscope Live Cell Recording System$274,692

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamProfessor Dirk Van Helden, Laureate Professor John Aitken, Professor Eileen McLaughlin, Professor Alan Brichta, Associate Professor J Keast, Dr J Brock, Dr S Head
SchemeLinkage Infrastructure Equipment & Facilities (LIEF)
RoleInvestigator
Funding Start2004
Funding Finish2004
GNoG0183031
Type Of FundingScheme excluded from IGS
CategoryEXCL
UONY

High-speed Confocal Microscope Live Cell Recording System$30,000

Funding body: University of New South Wales

Funding bodyUniversity of New South Wales
Project TeamProfessor Dirk Van Helden, Associate Professor J Keast, Laureate Professor John Aitken, Dr J Brock, Professor Eileen McLaughlin, Dr S Head, Professor Alan Brichta
SchemeLinkage Infrastructure Equipment & Facilities (LIEF) Partner funding
RoleInvestigator
Funding Start2004
Funding Finish2004
GNoG0183841
Type Of FundingNot Known
CategoryUNKN
UONY

Activation of the mammalian primordial follicle.$8,500

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Eileen McLaughlin
SchemeProject Grant
RoleLead
Funding Start2004
Funding Finish2004
GNoG0183443
Type Of FundingInternal
CategoryINTE
UONY

20034 grants / $9,492,900

Centre for Biotechnology and Development.$9,458,900

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamLaureate Professor John Aitken, Dr Kate Loveland, Professor P Koopman, Assoc. Prof A Sinclair, Professor D De Krester, Dr M O'Bryan, Dr Gary Hime, Professor D Jans, Doctor Shaun Roman, Professor Eileen McLaughlin, Professor C Goodnow, Professor M Holland
SchemeARC Centres of Excellence
RoleInvestigator
Funding Start2003
Funding Finish2003
GNoG0182214
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

The role of cytokines in the activation of the ovarian follicle.$17,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamProfessor Eileen McLaughlin, Laureate Professor John Aitken
SchemeResearch Grant
RoleLead
Funding Start2003
Funding Finish2003
GNoG0182197
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Oolemmal Proteomics - identification of oocyte cell surface protein complexes involved in sperm-egg interaction$12,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Eileen McLaughlin, Laureate Professor John Aitken
SchemeProject Grant
RoleLead
Funding Start2003
Funding Finish2003
GNoG0182320
Type Of FundingInternal
CategoryINTE
UONY

Profiling germ cell gene expression during spermatogonial differentiation$5,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Shaun Roman, Professor Eileen McLaughlin
SchemeProject Grant
RoleInvestigator
Funding Start2003
Funding Finish2003
GNoG0182402
Type Of FundingInternal
CategoryINTE
UONY

20021 grants / $12,000

Oocyte selection in the female germ line - survival of the fittest?$12,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Eileen McLaughlin
SchemeNew Staff Grant
RoleLead
Funding Start2002
Funding Finish2002
GNoG0182024
Type Of FundingInternal
CategoryINTE
UONY
Edit

Research Supervision

Current Supervision

CommencedResearch Title / Program / Supervisor Type
2015Chlamydial Infection in Males - is it a Significant Problem?
Biological Sciences, Faculty of Science and Information Technology
Principal Supervisor
2013The Impact of Maternal Ageing and Chemotoxicants on Female Fertility
Biological Sciences, Faculty of Science and Information Technology
Co-Supervisor
2012Hedgehog Signaling Pathway Inhibitors as Cancer Suppressing Agents
Biological Sciences, Faculty of Science and Information Technology
Co-Supervisor
2007Musashi 1 and 2 RNA binding proteins role in mammalian folliculogenesis
Biol Sc Not Elsewhere Classifd, University of Newcastle
Principal Supervisor
2007Chemokines and spermatogenesis
Biol Sc Not Elsewhere Classifd, University of Newcastle
Co-Supervisor
2007Oxidiative stress and Folliculogenesis
Biol Sc Not Elsewhere Classifd, University of Newcastle
Principal Supervisor

Past Supervision

YearResearch Title / Program / Supervisor Type
2015A Focus on the Essential Roles of the Musashi Family of RNA Binding Proteins during Mammalian Spermatogenesis
Biological Sciences, Faculty of Science and Information Technology
Principal Supervisor
2015Susceptibility of Mammalian Oocytes to Chromosome Segregation Errors with Maternal Aging
Human Biology, Faculty of Health and Medicine
Co-Supervisor
2013Regulation of the Transition from Gonocytes to Spermatogonia
Biological Sciences, Faculty of Science and Information Technology
Principal Supervisor
2013Translational Control of Mouse Folliculogenesis and Oocyte Development
Biological Sciences, Faculty of Science and Information Technology
Principal Supervisor
2013New Insights into the Molecular Basis of Human Sperm-Egg Interaction
Biological Sciences, Faculty of Science and Information Technology
Co-Supervisor
2012Xenobiotics; Effects on Female Fertility
Biological Sciences, Faculty of Science and Information Technology
Principal Supervisor
2008Oolemmal Proteomics: Identification of Oocyte Cell Surface Protein Complexes Involved in Murine Fertilisation
Biological Sciences, Faculty of Science and Information Technology
Principal Supervisor
2006Non-Surgical Sterilisation of Female Domesticated Animals
Biological Sciences, Faculty of Science and Information Technology
Principal Supervisor
2006Gene Expression During Development of the Mammalian Ovarian Primordial Follicle
Biological Sciences, Faculty of Science and Information Technology
Principal Supervisor
2005Non genomic action of progesterone in human spermatozoa
Biol Sc Not Elsewhere Classifd, University of Newcastle
Principal Supervisor
2005The Molecular Basis of Sperm-Oocyte Interaction in the Mouse
Biological Sciences, Faculty of Science and Information Technology
Co-Supervisor
2005Xenobiotics Effects on mammalian folliculogenesis
Biol Sc Not Elsewhere Classifd, University of Newcastle
Co-Supervisor
2004The role of Kit Ligand in primordial follicle activation in the juvenile rabbit ovary
Biol Sc Not Elsewhere Classifd, Australian National University
Consultant Supervisor
2004A novel GTPase activating protein RhGAPs in the male gamete
Biol Sc Not Elsewhere Classifd, University of Newcastle
Co-Supervisor
2004Supressors of Cytokine Signalling
Biol Sc Not Elsewhere Classifd, University of Newcastle
Principal Supervisor
2003Characterisation of the sperm progesterone receptor
Biol Sc Not Elsewhere Classifd, University of Newcastle
Co-Supervisor
Edit

News

Smoking and male fertility breakthrough finding

October 1, 2014

Mothers who smoke while they are pregnant or breast feeding may be damaging the future fertility of their sons, according to breakthrough findings from University of Newcastle researchers published today.

Professor Eileen McLaughlin

Position

Pro Vice-Chancellor (Interim)
PVC Unit FSCIT
Office PVC - Science and Information Technology
Faculty of Science and Information Technology

Focus area

Biological Sciences

Contact Details

Emaileileen.mclaughlin@newcastle.edu.au
Phone(02) 4921 5906
Mobile0437 091293
Fax(02) 4921 7949

Office

RoomV201A FSCIT PVC Unit
BuildingMathematics
LocationCallaghan
University Drive
Callaghan, NSW 2308
Australia
Edit